Frequent bathing leads to a skin barrier damage with various changes in physiological skin parame... more Frequent bathing leads to a skin barrier damage with various changes in physiological skin parameters. Conversely, ultraviolet (UV) irradiation may improve the impaired skin barrier by reducing inflammatory reactions. The aim of this study was to investigate the changes of physiological skin parameters during a therapy with 8-methoxypsoralen (8-MOP) bathing and subsequent UVA irradiation. Thirty patients with a skin disease without barrier disruption were treated with daily bathing in a 8-MOP solution (0.0005%) and subsequent UVA irradiation. Multiple physiological skin parameters (transepidermal water loss, skin blood flow, skin colour, sebum content, skin hydration) were measured repeatedly on clinically non-affected skin on the back, forearm and forehead. In addition, patch testing with sodium lauryl sulphate (SLS) (0.5%) was performed on the forearm and on the back. We found a moderate but significant disturbance of skin barrier and hydration on the forearm and the back (bathing + irradiation) after increasing dosages of therapy. In addition, SLS testing leads to stronger reactions. We conclude that on clinically healthy skin the impairment of skin barrier by frequent bathing cannot be completely compensated by subsequent UVA irradiation. When conducting a treatment with 8-MOP bathing and UVA irradiation a concomitant therapy supporting the recovery of skin barrier, e.g. with moisturizer, should be performed.
JDDG: Journal der Deutschen Dermatologischen Gesellschaft
SummaryBackgroundTREATgermany is a multicenter registry including patients with moderate‐to‐sever... more SummaryBackgroundTREATgermany is a multicenter registry including patients with moderate‐to‐severe atopic dermatitis (AD) from currently 74 study centers (university clinics, hospitals and practices) in Germany. As of August 31, 2021, 1,230 adult patients were enrolled.MethodsIn TREATgermany, patients and physicians fill in questionnaires pertaining to symptoms, disease severity, quality of life, depressiveness, and fatigue. In particular, limitations in work performance are assessed using the Work Limitations Questionnaire (WLQ). To assess associations between occupational performance/work limitations and symptoms, correlations and regression models were calculated.ResultsThe examined sample of 228 employed patients reported an average of 6% at‐work productivity loss within the past two weeks prior to enrolment in the registry. The WLQ productivity loss score was moderately associated with itch (r = 0.32) and sleep loss (r = 0.39) and strongly associated with depressive symptoms (r...
This interim analysis from the atopic dermatitis registry TREATgermany shows robust long-term eff... more This interim analysis from the atopic dermatitis registry TREATgermany shows robust long-term efficacy, favourable safety and high persistence of dupilumab under real life conditions.
Das Soziale in Medizin und Gesellschaft – Aktuelle Megatrends fordern uns heraus 56. Jahrestagung der Deutschen Gesellschaft für Sozialmedizin und Prävention (DGSMP), 2021
Journal of the European Academy of Dermatology and Venereology, 2019
BackgroundThe Atopic Dermatitis (AD) TREATgermany registry was initiated by the German Society fo... more BackgroundThe Atopic Dermatitis (AD) TREATgermany registry was initiated by the German Society for Dermatology (DDG) in 2011 to evaluate the ‘real‐life’ situation of health care for patients with AD.ObjectivesInterim data analysis on baseline characteristics as well as current and prescribed systemic treatments of the TREATgermany registry patients.MethodsPatients (≥18 years) with moderate‐to‐severe AD [objective (o)SCORAD > 20], or with current or previous anti‐inflammatory systemic treatment for AD within 24 months, were included and are followed up over at least 24 months. To assess clinical signs, the eczema area severity index (EASI, 0–72), the oSCORAD (0–83) and the Investigator Global Assessment (IGA; 6‐point scale) were used. The disease severity was globally scored by the patients [Patient Global Assessment (PGA); six‐step Likert scale]. Disease symptoms were assessed by the patient‐oriented eczema measure (POEM, 0–28) and numeric rating scales (NRS, 0–10). Health‐relate...
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2022
ZusammenfassungHintergrundTREATgermany, ein Register für Patienten mit moderater bis schwerer ato... more ZusammenfassungHintergrundTREATgermany, ein Register für Patienten mit moderater bis schwerer atopischer Dermatitis (AD), etablierte im Frühjahr 2020 einen zusätzlichen Fragebogen, um Auswirkungen der Corona‐Pandemie auf die Lebenssituation von Patienten mit AD zu untersuchen.MethodikAnhand eines Fragebogens wurden allgemeine Informationen zum Erleben der Corona‐Pandemie und, unter Anwendung des Inventars lebensverändernder Ereignisse, die resultierenden Belastungen der Patienten untersucht. Zur Analyse möglicher Assoziationen zwischen Erkrankungsschwere (EASI‐Score, oSCORAD, IGA, PGA, POEM), Lebensqualität (DLQI) und persönlichen Belastungen wurden t‐Tests, Varianzanalysen und Korrelationen kontrolliert nach Geschlecht und Alter genutzt.Ergebnisse58 % (N = 233) der einbezogenen 400 Registerpatienten berichteten eine hohe Belastung durch die Corona‐Pandemie, unabhängig von einer tatsächlichen Infektion. Männer zeigten signifikant höhere Belastungswerte als Frauen sowie jüngere höher...
Secukinumab demonstrates efficacy, safety and tolerability upon administration by 2 mL autoinject... more Secukinumab demonstrates efficacy, safety and tolerability upon administration by 2 mL autoinjector in adult patients with plaque psoriasis: 52-week results from MATURE, a randomized, placebo-controlled trial
We report a case of an erythema multiforme-like eruption following topical application of a lotio... more We report a case of an erythema multiforme-like eruption following topical application of a lotion containing bufexamac. Patch testing revealed sensitization to bufexamac. As a possible pathogenetic mechanism, deposition of immune complexes in the small vessels has been proposed
Das Soziale in Medizin und Gesellschaft – Aktuelle Megatrends fordern uns heraus 56. Jahrestagung der Deutschen Gesellschaft für Sozialmedizin und Prävention (DGSMP), 2021
Frequent bathing leads to a skin barrier damage with various changes in physiological skin parame... more Frequent bathing leads to a skin barrier damage with various changes in physiological skin parameters. Conversely, ultraviolet (UV) irradiation may improve the impaired skin barrier by reducing inflammatory reactions. The aim of this study was to investigate the changes of physiological skin parameters during a therapy with 8-methoxypsoralen (8-MOP) bathing and subsequent UVA irradiation. Thirty patients with a skin disease without barrier disruption were treated with daily bathing in a 8-MOP solution (0.0005%) and subsequent UVA irradiation. Multiple physiological skin parameters (transepidermal water loss, skin blood flow, skin colour, sebum content, skin hydration) were measured repeatedly on clinically non-affected skin on the back, forearm and forehead. In addition, patch testing with sodium lauryl sulphate (SLS) (0.5%) was performed on the forearm and on the back. We found a moderate but significant disturbance of skin barrier and hydration on the forearm and the back (bathing + irradiation) after increasing dosages of therapy. In addition, SLS testing leads to stronger reactions. We conclude that on clinically healthy skin the impairment of skin barrier by frequent bathing cannot be completely compensated by subsequent UVA irradiation. When conducting a treatment with 8-MOP bathing and UVA irradiation a concomitant therapy supporting the recovery of skin barrier, e.g. with moisturizer, should be performed.
JDDG: Journal der Deutschen Dermatologischen Gesellschaft
SummaryBackgroundTREATgermany is a multicenter registry including patients with moderate‐to‐sever... more SummaryBackgroundTREATgermany is a multicenter registry including patients with moderate‐to‐severe atopic dermatitis (AD) from currently 74 study centers (university clinics, hospitals and practices) in Germany. As of August 31, 2021, 1,230 adult patients were enrolled.MethodsIn TREATgermany, patients and physicians fill in questionnaires pertaining to symptoms, disease severity, quality of life, depressiveness, and fatigue. In particular, limitations in work performance are assessed using the Work Limitations Questionnaire (WLQ). To assess associations between occupational performance/work limitations and symptoms, correlations and regression models were calculated.ResultsThe examined sample of 228 employed patients reported an average of 6% at‐work productivity loss within the past two weeks prior to enrolment in the registry. The WLQ productivity loss score was moderately associated with itch (r = 0.32) and sleep loss (r = 0.39) and strongly associated with depressive symptoms (r...
This interim analysis from the atopic dermatitis registry TREATgermany shows robust long-term eff... more This interim analysis from the atopic dermatitis registry TREATgermany shows robust long-term efficacy, favourable safety and high persistence of dupilumab under real life conditions.
Das Soziale in Medizin und Gesellschaft – Aktuelle Megatrends fordern uns heraus 56. Jahrestagung der Deutschen Gesellschaft für Sozialmedizin und Prävention (DGSMP), 2021
Journal of the European Academy of Dermatology and Venereology, 2019
BackgroundThe Atopic Dermatitis (AD) TREATgermany registry was initiated by the German Society fo... more BackgroundThe Atopic Dermatitis (AD) TREATgermany registry was initiated by the German Society for Dermatology (DDG) in 2011 to evaluate the ‘real‐life’ situation of health care for patients with AD.ObjectivesInterim data analysis on baseline characteristics as well as current and prescribed systemic treatments of the TREATgermany registry patients.MethodsPatients (≥18 years) with moderate‐to‐severe AD [objective (o)SCORAD > 20], or with current or previous anti‐inflammatory systemic treatment for AD within 24 months, were included and are followed up over at least 24 months. To assess clinical signs, the eczema area severity index (EASI, 0–72), the oSCORAD (0–83) and the Investigator Global Assessment (IGA; 6‐point scale) were used. The disease severity was globally scored by the patients [Patient Global Assessment (PGA); six‐step Likert scale]. Disease symptoms were assessed by the patient‐oriented eczema measure (POEM, 0–28) and numeric rating scales (NRS, 0–10). Health‐relate...
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2022
ZusammenfassungHintergrundTREATgermany, ein Register für Patienten mit moderater bis schwerer ato... more ZusammenfassungHintergrundTREATgermany, ein Register für Patienten mit moderater bis schwerer atopischer Dermatitis (AD), etablierte im Frühjahr 2020 einen zusätzlichen Fragebogen, um Auswirkungen der Corona‐Pandemie auf die Lebenssituation von Patienten mit AD zu untersuchen.MethodikAnhand eines Fragebogens wurden allgemeine Informationen zum Erleben der Corona‐Pandemie und, unter Anwendung des Inventars lebensverändernder Ereignisse, die resultierenden Belastungen der Patienten untersucht. Zur Analyse möglicher Assoziationen zwischen Erkrankungsschwere (EASI‐Score, oSCORAD, IGA, PGA, POEM), Lebensqualität (DLQI) und persönlichen Belastungen wurden t‐Tests, Varianzanalysen und Korrelationen kontrolliert nach Geschlecht und Alter genutzt.Ergebnisse58 % (N = 233) der einbezogenen 400 Registerpatienten berichteten eine hohe Belastung durch die Corona‐Pandemie, unabhängig von einer tatsächlichen Infektion. Männer zeigten signifikant höhere Belastungswerte als Frauen sowie jüngere höher...
Secukinumab demonstrates efficacy, safety and tolerability upon administration by 2 mL autoinject... more Secukinumab demonstrates efficacy, safety and tolerability upon administration by 2 mL autoinjector in adult patients with plaque psoriasis: 52-week results from MATURE, a randomized, placebo-controlled trial
We report a case of an erythema multiforme-like eruption following topical application of a lotio... more We report a case of an erythema multiforme-like eruption following topical application of a lotion containing bufexamac. Patch testing revealed sensitization to bufexamac. As a possible pathogenetic mechanism, deposition of immune complexes in the small vessels has been proposed
Das Soziale in Medizin und Gesellschaft – Aktuelle Megatrends fordern uns heraus 56. Jahrestagung der Deutschen Gesellschaft für Sozialmedizin und Prävention (DGSMP), 2021
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