Journal of Pharmacology and Experimental Therapeutics, 1966
The cardiac glycoside ouabain, even while inhibiting the active transport of Na+ and K+ ions, bri... more The cardiac glycoside ouabain, even while inhibiting the active transport of Na+ and K+ ions, brings about an increase in respiration of cerebral cortex slices. This effect has now been found to depend upon the presence of Ca++ ions in the medium bathing the slice. Slices of guinea-pig cortex incubated in glycyiglycine-buffered media containing 10-4 M ouabain respired at rates 60% above normal when media contained 2.8 mM CaCl2 . When Ca++ ions were omitted, inhibition of respiration occurred, which reached 70% after 75 min. Decrease in slice content of intracellular K+ and increase in intracellular Na+ were less marked in Ca++-containing media. The respiration increase was also abolished in the presence of the basic polypeptide protamine. Results were interpreted to indicate that Ca++ ions and membrane acidic groups help to maintain the physical integrity of the cell membrane structure and thereby prevent ouabain from combining with a portion of the Na+ + K+-dependent adenosine trip...
... n. Shackman, Joshua. IE. ... hauer; Cheryl Woodruff for her editorial expertise; John J. Ulli... more ... n. Shackman, Joshua. IE. ... hauer; Cheryl Woodruff for her editorial expertise; John J. Ullis for his never-ending computer technology support; and Harianto ... I have seen huge changes in the personalities of men and women with depressed testosterone levels; they become happy ...
The responses of 582 male university students attending the UCLA Student Health Service for medic... more The responses of 582 male university students attending the UCLA Student Health Service for medical evaluation are presented. Of these students, 37% (215) were freshmen and varsity athletes having pretraining physicals, and 63% (367) were students being evaluated in the SHS primary care clinics. A self-report questionnaire examined the frequency of sexual problems experienced by the respondents and their partners.
Tonsillar tissue may be the primary site of infection with Epstein-Barr virus (EBV), the etiologi... more Tonsillar tissue may be the primary site of infection with Epstein-Barr virus (EBV), the etiologic agent of classical infectious mononucleosis (IM). Therefore, a retrospective study of the association between tonsillectomy and IM was performed in a college student population. In the first part of the study, tonsillectomy rates were compared between 164 IM-positive students and 164 student controls who attended UCLA in 1972-1975. Although it was determined that the development of IM during college years was statistically less commin in tonsillectomized students, the difference was not inordinately large and probably had no significant biologic meaning. The authors speculate that the difference was due to the greater likelihood, and greater yield, in considering the diagnosis of IM in young adults with enlarged, inflamed tonsils. In support of this is the fact that IM-positive students who had received a prior tonsillectomy usually had the surgical procedure performed at a younger age...
The frequency of clinically evident genital infections with herpes simplex virus among students a... more The frequency of clinically evident genital infections with herpes simplex virus among students attending a large urban public university was studied. One-hundred ninety-eight students experienced 222 episodes of this disease over a one-year period. The mean age of the students, both undergraduate and graduate, with the diagnosis of genital herpes ranged from 23.6 years for those with a single initial episode to 24.9 years for those with recurrent episodes. The male-to-female ratio and socioeconomic class of students with genital herpes were not significantly different from those of the general university population. The incidences of both initial and recurrent episodes of genital herpes were statistically significantly higher during the months of July through October (with the exception of September). Genital herpes was a frequently diagnosed sexually transmitted disease among this student population.
The responses of 582 male university students attending the UCLA Student Health Service for medic... more The responses of 582 male university students attending the UCLA Student Health Service for medical evaluation are presented. Of these students, 37% (215) were freshmen and varsity athletes having pretraining physicals, and 63% (367) were students being evaluated in the SHS primary care clinics. A self-report questionnaire examined the frequency of sexual problems experienced by the respondents and their partners.
This study retrospectively examines 186 patients treated for roller skating-related injuries. The... more This study retrospectively examines 186 patients treated for roller skating-related injuries. The average patient age was 25.3 years, with males comprising 44% and females 56% of the patients. Of the 202 injuries, there were 130 fractures and 72 soft tissue injuries. The majority of the injuries involved the wrist (47%), while the elbow ranked second (14%) and the ankle third (10%). All fractures of the tibia-fibula and ankle involved a rotational mechanism, with 75% of ankle fractures involving the posterior malleolus. Ankle fractures accounted for 46% of all surgical cases. Although inexperienced skaters were involved in 77% of all accidents, experienced skaters' injuries required surgery twice as often. Female roller skaters were more frequently injured, but males had three times more operations. Over 90% of the skaters wore no protection. Skaters who seldom participated in other sports had a higher probability of being injured earlier, especially on their first try. This study indicates that roller skating injuries are influenced by skating experience, surface texture, skate type and quality, and protective equipment.
Journal of Pharmacology and Experimental Therapeutics, 1966
The cardiac glycoside ouabain, even while inhibiting the active transport of Na+ and K+ ions, bri... more The cardiac glycoside ouabain, even while inhibiting the active transport of Na+ and K+ ions, brings about an increase in respiration of cerebral cortex slices. This effect has now been found to depend upon the presence of Ca++ ions in the medium bathing the slice. Slices of guinea-pig cortex incubated in glycyiglycine-buffered media containing 10-4 M ouabain respired at rates 60% above normal when media contained 2.8 mM CaCl2 . When Ca++ ions were omitted, inhibition of respiration occurred, which reached 70% after 75 min. Decrease in slice content of intracellular K+ and increase in intracellular Na+ were less marked in Ca++-containing media. The respiration increase was also abolished in the presence of the basic polypeptide protamine. Results were interpreted to indicate that Ca++ ions and membrane acidic groups help to maintain the physical integrity of the cell membrane structure and thereby prevent ouabain from combining with a portion of the Na+ + K+-dependent adenosine trip...
... n. Shackman, Joshua. IE. ... hauer; Cheryl Woodruff for her editorial expertise; John J. Ulli... more ... n. Shackman, Joshua. IE. ... hauer; Cheryl Woodruff for her editorial expertise; John J. Ullis for his never-ending computer technology support; and Harianto ... I have seen huge changes in the personalities of men and women with depressed testosterone levels; they become happy ...
The responses of 582 male university students attending the UCLA Student Health Service for medic... more The responses of 582 male university students attending the UCLA Student Health Service for medical evaluation are presented. Of these students, 37% (215) were freshmen and varsity athletes having pretraining physicals, and 63% (367) were students being evaluated in the SHS primary care clinics. A self-report questionnaire examined the frequency of sexual problems experienced by the respondents and their partners.
Tonsillar tissue may be the primary site of infection with Epstein-Barr virus (EBV), the etiologi... more Tonsillar tissue may be the primary site of infection with Epstein-Barr virus (EBV), the etiologic agent of classical infectious mononucleosis (IM). Therefore, a retrospective study of the association between tonsillectomy and IM was performed in a college student population. In the first part of the study, tonsillectomy rates were compared between 164 IM-positive students and 164 student controls who attended UCLA in 1972-1975. Although it was determined that the development of IM during college years was statistically less commin in tonsillectomized students, the difference was not inordinately large and probably had no significant biologic meaning. The authors speculate that the difference was due to the greater likelihood, and greater yield, in considering the diagnosis of IM in young adults with enlarged, inflamed tonsils. In support of this is the fact that IM-positive students who had received a prior tonsillectomy usually had the surgical procedure performed at a younger age...
The frequency of clinically evident genital infections with herpes simplex virus among students a... more The frequency of clinically evident genital infections with herpes simplex virus among students attending a large urban public university was studied. One-hundred ninety-eight students experienced 222 episodes of this disease over a one-year period. The mean age of the students, both undergraduate and graduate, with the diagnosis of genital herpes ranged from 23.6 years for those with a single initial episode to 24.9 years for those with recurrent episodes. The male-to-female ratio and socioeconomic class of students with genital herpes were not significantly different from those of the general university population. The incidences of both initial and recurrent episodes of genital herpes were statistically significantly higher during the months of July through October (with the exception of September). Genital herpes was a frequently diagnosed sexually transmitted disease among this student population.
The responses of 582 male university students attending the UCLA Student Health Service for medic... more The responses of 582 male university students attending the UCLA Student Health Service for medical evaluation are presented. Of these students, 37% (215) were freshmen and varsity athletes having pretraining physicals, and 63% (367) were students being evaluated in the SHS primary care clinics. A self-report questionnaire examined the frequency of sexual problems experienced by the respondents and their partners.
This study retrospectively examines 186 patients treated for roller skating-related injuries. The... more This study retrospectively examines 186 patients treated for roller skating-related injuries. The average patient age was 25.3 years, with males comprising 44% and females 56% of the patients. Of the 202 injuries, there were 130 fractures and 72 soft tissue injuries. The majority of the injuries involved the wrist (47%), while the elbow ranked second (14%) and the ankle third (10%). All fractures of the tibia-fibula and ankle involved a rotational mechanism, with 75% of ankle fractures involving the posterior malleolus. Ankle fractures accounted for 46% of all surgical cases. Although inexperienced skaters were involved in 77% of all accidents, experienced skaters' injuries required surgery twice as often. Female roller skaters were more frequently injured, but males had three times more operations. Over 90% of the skaters wore no protection. Skaters who seldom participated in other sports had a higher probability of being injured earlier, especially on their first try. This study indicates that roller skating injuries are influenced by skating experience, surface texture, skate type and quality, and protective equipment.
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