Papers by Eduardo Mello De Capitani
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Toxicon
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Clinical Toxicology, 2018
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Revista brasileira de medicina, 2004
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Clinical Toxicology, 2020
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American Journal of Industrial Medicine, 2019
ObjectiveTo evaluate the frequency and severity of pleuropulmonary alterations in anthophyllite‐e... more ObjectiveTo evaluate the frequency and severity of pleuropulmonary alterations in anthophyllite‐exposed former workers in Itapira, São Paulo, Brazil. The amphibole anthophyllite, a magnesium‐iron silicate, had its mining, marketing, and use forbidden in Brazil in 1995.MethodsFormer workers were followed from 1999 to 2011. All completed chest X‐ray interpreted using the International Labour Office (ILO) classification. High‐resolution computed tomography was used at the final evaluation. Spirometry assessed forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), and FEV1/FVC throughout the follow‐up period. Samples from the mined ore were analyzed by X‐ray diffraction (XRD) and scanning electron microscopy coupled to energy dispersive spectroscopy (SEM‐EDS).ResultsXRD and SEM‐EDS confirmed the presence in ore of anthophyllite at a concentration of 75%, in addition to tremolite and other amphiboles in lower concentrations. Twenty‐eight subjects were evaluated...
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European journal of trauma and emergency surgery : official publication of the European Trauma Society, Jan 7, 2017
The abuse of cocaine and its derivatives presents a likely risk factor for injury. Trauma incurre... more The abuse of cocaine and its derivatives presents a likely risk factor for injury. Trauma incurred by cocaine and derivative abusers may be more severe than that incurred by non-users. To ascertain the presence of cocaine and its derivatives in trauma patients and to correlate RTS (Revised Trauma Score) and ISS (Injury Severity Score) with the presence of cocaine and its derivatives in blood and urine samples. All trauma victims treated in an emergency unit between November 11, 2012 and September 15, 2013 were included in the study. Blood and urine samples were collected on admission to hospital. RTS and ISS scores were then compared with the presence or absence of cocaine and its derivatives in the samples. The associations between RTS < 7.84 and ISS > 16 and the independent variables were evaluated by the gross odds ratio values, determined by univariate logistic regression. Multivariate analysis was performed using multivariate logistic regression. Of 453 patients (83.7% ma...
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European Respiratory Journal, 2016
Background: Computed tomography (CT) allows phenotyping of COPD patients, but its relationship wi... more Background: Computed tomography (CT) allows phenotyping of COPD patients, but its relationship with functional features are unclear. Volumetric capnography (VC) uses the principle of gas washout and analyzes the pattern of CO2 elimination as a function of expired volume. Aim: Discover if VC allows the identification of subsets of patients with distinct capnographic profiles among the CT phenotyped COPD ones. Method: Severe COPD patients were subjected to clinical evaluation, high-resolution CT, and VC, whose main variables were end-tidal concentration of CO2 (ETCO2), phase 2 slope (Slp2), and phase 3 (Slp3) of the capnogram. CT scans were used to phenotype each patient as having emphysema (EMP) or airway disease (AWD); these groups had its CT scores, clinical, spirometric and VC variables compared. Result: Of 65 subjects (64.2 years, 66.2% males, FEV1= 39.8±14.1), 34 had EMP, and 31 AWD phenotypes. When comparing EMP and AWD patients, EMP patients had significantly lower body mass index and FEV1 (%pred). Concerning VC, EMP patients had significantly lower ETCO2 (33.7vs39 mmHg), Slp2 (192vs305.7 mmHg/L) and Slp3 (28.6vs37.1 mmHg/L). Slp2 represents the sharp increase in CO2 concentration just after dead space9s exhalation, which illustrates CO2 elimination from the shortest air paths, usually found in lungs9 apical regions. As emphysema affects mainly these areas, Slp2 reduction may be explained by the decrease of these shorter pathways. Slp3 was significantly higher in AWD patients, and characterizes heterogeneous involvement of distal air spaces, which is quite common in AWD patients. Conclusion: In this study, VC was able to detect an unique capnographic profile in each of the CT phenotypes of COPD patients.
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| Context: The oral health status of workers and their implications for quality of life, with emp... more | Context: The oral health status of workers and their implications for quality of life, with emphasis on epidemiological data for planning health programs of the worker, is the focus of the quantitative analysis of articles published from the year 1990, the focus of this work. Objectives: This is a review of literature addressing oral health and its influence on quality of life of workers. It is based on evidence found in literature, considering the difficulties in finding articles related to the subject. Methods: Were consulted the databases of BBO, indexed, MEDLINE, LILACS, COCHRANE, for publications in the period 1990-2012. Results: Only 31 scientific works have been found with the referred approach. Conclusions: There is little space available in journals for publishing research related to oral health worker, which indicates the need for reflection on the scientific production, as this is able to provide professional training committed to quality of life and health of the community.
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Journal de Physique IV (Proceedings), 2003
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Epidemiology, 2003
ABSTRACT Bauru is a development pole of the state of Sao Paulo, with 321.580 inhabitants and 674K... more ABSTRACT Bauru is a development pole of the state of Sao Paulo, with 321.580 inhabitants and 674Km2. In February 2002, the environmental agency of the state (CETESB) communicated the State Health Department a lead contamination in the surroundings of an industry that recovers automobile batteries. The air emission levels of the industry reached 37.3[mu]g/m3 with an average of 9.7[mu]g/m3. Brazil does not use lead in gasoline since the 1970 decade. The company is in an agricultural area and there are recent population nuclei to the north and east. Soil, water, farming products and dust in the residences were evaluated for lead. We collected blood simples of chidren less than twelve years old, resident up to 1000m from the industry, with parents written consent. The quantification limit of the adopted method was 5[mu]g/dL. Values below the quantification limit were replaced by 2.5[mu]g/dL. The possible sources of lead exposition were inquired in parents by questionnaires. Two categories were created (&lt; 10 and &gt; = 10[mu]g/dL of blood lead levels) and the risk factors for high blood lead levels were evaluated in single logistic regression. The different blood lead levels averages were evaluated according to risk factors using non parametric approaches, since the distribution of results was not homogeneous. The data were analysed by multiple logistic regression, where the variables that presented p &lt; 0.20 in the single analysis were introduced. Interaction was tested when necessary. The investigation involved 624 children with blood lead level average of 9.28[mu]g/dL. Of these, 295 (35.8%) presented blood lead level &gt; = 10[mu]g/dL. The blood lead levels averages were statistically higher considering: to live less than 500m of the factory, to live in non paved street and consumption of local milk. In the final model of the logistic regression, to live in non paved street presented OR = 7.46(CI95%: 4.60;12.10). Others variables that remained significant were: to live less than 500m of the factory-OR = 2.42 (CI95%:1.62;3.63); to play on the ground-OR = 1.55 (CI95%:1.03;2.31) and father working in the source-OR = 1.52 (CI95%:1.13;2.03). The soil analysis outside the company, made in diverse depths, found lead levels above the intervention limit only in the most superficial samples (0-2cm). Of the investigated farming products, mint and eggs were improper for consumption. The lead levels of the dust in the residences were up to 6000ppm (while in the control area it was of 50ppm). All these factors indicate that the contamination is on superficial soil, being the contact with the soil a determinant factor of high blood lead levels. Remove the superficial soil in the non paved area (0-5cm); interdiction of the company (until lead emissions at a safe rate); aspiration of the residences and environmental education were recommended as control measures. (C) 2003 Lippincott Williams &amp; Wilkins, Inc.
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Geochemical soil analysis is largely used to identify areas with high and low concentrations of t... more Geochemical soil analysis is largely used to identify areas with high and low concentrations of trace-elements. It is also an excellent criterion to assess a given metal’s accumulation in the soil, to guide studies on potential occurrences of nutritional (in plants and animals), human health and environmental problems. The chemical composition data of Brazilian soils is scarce and concentrated in a few regions of the country, particularly São Paulo, and only for a couple of elements, usually micro-nutrients. This study presents an up-to-date panorama of soil geochemistry research in Brazil and suggests improvement initiatives to establish reference trace-metal values important to human health.
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sem informaçãosem informaçãoThe lack of adequate and prompt availability of antidotes is a worldw... more sem informaçãosem informaçãoThe lack of adequate and prompt availability of antidotes is a worldwide problem, with potentially disastrous consequences. We evaluated the availability of antidotes used in the treatment of poisonings in public and private emergency departments in the municipality of Campinas, S ã o Paulo state, Brazil. Methods: A structured questionnaire was sent to the pharmacy directors of public and private emergency departments in the municipality of Campinas. The availability, amount in stock, place of storage, and access time in the emergency room (immediately or within the fi rst hour) were investigated for 31 antidotes in 33 pharmaceutical preparations. A stock was defi ned as at least one full antidote treatment per service per 70 kg adult. The selection of antidotes was based on stock recommendations contained in published international guidelines. 1,2 Antivenoms were not included in the analysis. Results: Questionnaires were completed by 14 of 17 emergency d...
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O autor, atraves de estudo epidemiologico descritivo, analisa a ocorrencia de pneumoconiose em tr... more O autor, atraves de estudo epidemiologico descritivo, analisa a ocorrencia de pneumoconiose em trabalhadores ligados a manipulacao de rocha fosfatica em depositos localizados no Municipio de Paulinia, SP., em 1984. Estuda 73 trabalhadores expostos a essa materia-prima e constata a ocorrencia de 20 casos de pneumoconiose (27,43). Inclui no estudo investigacao radiologica de torax, provas de funcao pulmonar, citologia de escarro e biopsia de pulmao, alem de exame fTsico, como instrumentos de elucidacao diagnostica e etiologica. Constata serem os trabalhadores a cometidos assintomaticos na sua maioria, com provas de funcao pulmonar pouco alteradas, com predominância de alteracoes de pequenas vias aereas, com 2 (dois) casos com padrao levemente restritivo. A biopsia de pulmao nao revelou grau de fibrose significativo. A analise do material inalado, atraves de espectrometria de Raios-X e metodos colorimetricos nao evidenciou teor de silica-livre suficiente para promover fibrose pulmonar. O autor conclui tratar-se de pneumoconiose nao fibrogenica, de evolucao clinica ainda nao conhecida, a ser investigada utilizando-se estudos prospectivos. Recomenda o afastamento dos trabalhadores acometidos, e alteracoes no processo de trabalho do referido deposito visando a prevencao de novos casos. Abstract
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Lung cancer is a multifactorial disease. Hereditary, genetic, and environmental factors interact ... more Lung cancer is a multifactorial disease. Hereditary, genetic, and environmental factors interact in its genesis. The principal risk factor for lung cancer is smoking. However, the workplace provides an environment in which there is a risk of exposure to carcinogens. The International Agency for Research on Cancer currently lists 19 substances/work situations/occupations that have been proven to be associated with lung cancer (group 1). Thorough occupational history taking is not widely practiced in patients with lung cancer, which has a negative impact on the investigation of causality and, consequently, on the identification of cases of occupational cancer. The objectives of this review were to list the agents that are recognized as causes of lung cancer, to discuss the contribution of occupation to the development of the disease, to cite national studies on the subject, and to propose a list of procedures that are essential to the appropriate investigation of causality between lun...
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Papers by Eduardo Mello De Capitani