Papers by Damien Tshibangu
Journal of complementary and alternative medical research, Dec 4, 2017
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Science journal of University of Zakho, Dec 4, 2023
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International blood research & reviews, Jan 10, 2014
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Zenodo (CERN European Organization for Nuclear Research), Jan 26, 2023
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International Journal of Innovation and Applied Studies, Jan 15, 2016
The use of great apes Pharmacopoeia or zoo-pharmacognosy is a very promising strategy for the tre... more The use of great apes Pharmacopoeia or zoo-pharmacognosy is a very promising strategy for the treatment of human diseases due to the phylogenetic proximity of humans and non-human primates (NHP) as Bonobos. In total, more than 40 direct fields' observations of bonobos have been performed for five months. A high number of direct observations were recorded in August followed by September while there was less observations in June. The average size and composition of the group for August is estimated at 19 individuals with 8 males, 9 females and 2 young whereas the size recorded in September was of 12 individuals including 5 males, 6 females and 1 young. Physicochemical and blood-biochemical analysis results performed on bonobos urine within their natural habitat shown the presence of bilirubin in some urine specimens (a formation of an azo derivative with a diazonium salt). The presence of a lot of leukocytes in urine is an indication of Plasmodium infection since we are in Malaria endemic regions. These results confirm the evidence of great ape pathological condition and then these could be considered as a biological model for testing and/or validating the self-medication hypothesis and the anti-hemolytic effects of plants consumed by NHP that could be profitable to the sickle cell individuals. The survey revealed that the pharmacopoeia of bonobos of Lomako Nature Reserve consists of 35 plant species. The bioassay test showed that Treculia africana, a plant being part of the diet of the bonobos, inhibits the sickling of red blood cells in vitro in hypoxic conditions and can serve as a source of bioactive metabolites for promoting an antisickling nutritherapy in Democratic Republic of the Congo. The relationship between the pharmacopoeia of apes and sickle cell anemia is an original approach. Thus, it opens up new perspectives for the treatment of this hemoglobinopathy through modulating effects of secondary metabolites of plant origin on the epi-genome.
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Tropical plant research, Nov 30, 2017
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International blood research & reviews, Jan 10, 2015
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IJFAC (Indonesian Journal of Fundamental and Applied Chemistry), Oct 25, 2022
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AIMS Materials Science
Each year more than 150, 000 tons of dyes are released in effluents by industries. These chemical... more Each year more than 150, 000 tons of dyes are released in effluents by industries. These chemicals entities non-biodegradable and toxic can be removed from effluent by metallic nanomaterials. The aqueous extract of Manotes expansa leaves is used as reducing and stabilizing agent in the biogenic synthesis of Mn-CuO nanocomposites. The nanoparticles obtained were characterized using UV-visible spectroscopy, X-ray Diffraction (XRD), X-ray Fluorescence, Dynamic Light Scattering (DSL), and Scanning Electron Microscopy (SEM). The hemotoxicity of biosynthesized nanomaterials was assessed by evaluating their hemolytic activity using erythrocytes as a model system. The photocatalytic activity of Mn-CuO was carried out by photocatalytic degradation of Methylene Blue dye as a model. The results obtained by UV-vis spectroscopy showed a Plasmonic Surface Resonance band at 408 nm. XRD and X-ray fluorescence made it possible to identify the presence of particles of formula Mn0.53Cu0.21O having cry...
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Journal of Botanical Research
The aim of this study was to evaluate the ethnomedical knowledge of the population of South Ubang... more The aim of this study was to evaluate the ethnomedical knowledge of the population of South Ubangi on Myrianthus arboreus, a plant consumed by chimpanzees, with the assumption that this bio-resource is also used by the population in African Traditional Medicine to treat common diseases. The results revealed that M. arboreus treats 23 diseases in the province of South Ubangi in Democratic Republic of the Congo. Of these diseases, six (anaemia, bronchitis, tooth decay, gastritis, hypertension, and spleen) are the most cited. Anaemia and spleen are treated by all socio-cultural groups. The leaf is the most used organ (48%) followed by sap, roots, stems, bark, flowers, and seeds. Expression (61.5%) is the most used method of preparation followed by decoction, maceration, and mastication. Oral (94.5%) is the most used method of administration followed by body bath, massage, anal and auricular route. M. arboreus is a vulnerable species (Iv ≥ 2.5) in the study area. The diseases treated ar...
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Zenodo (CERN European Organization for Nuclear Research), Jul 18, 2022
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Annual Research & Review in Biology
Aim: The objective of this study was to determine the phytochemical profile of Senna alata LINN u... more Aim: The objective of this study was to determine the phytochemical profile of Senna alata LINN using chemical screening in solution and thin-layer chromatography, and to assess the antioxidant and anthelmintic activities of the plant’s aqueous extracts. Methodology: All the analyses performed in this study were, respectively, done as described by the standard protocols. These were: the microscopic examination of the plant powders performed using a light microscope, the search for secondary metabolites carried out by chemical screening in solution and by thin-layer chromatography, the determination of the secondary metabolites, and the antioxidant activity carried out by UV-visible spectroscopy and the anthelmintic activity performed by dilution in decreasing order of concentration. Results: Micrographic analysis of the powder of Senna alata revealed the histological elements rich in unicellular covering hairs with a punctate surface and in fragments of palisade parenchyma, with elo...
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South Asian Research Journal of Natural Products, Mar 19, 2018
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International Journal of Pathogen Research, 2022
Aims: The objective of this study was to determine the phytochemical profile of Centella asiatica... more Aims: The objective of this study was to determine the phytochemical profile of Centella asiatica, Citrus grandis and Zanthoxylum gilletii leaves, in solution and the thin layer chromatography chemical screening and to evaluate the antibacterial photodynamic activity of the species extracts. Materials and Methods: The search of the secondary metabolites in solution and by thin layer chromatography, the alkaloids and polyphenols extraction were carried out using standard protocols. The antibacterial photodynamic activity was performed using microdilution method in solution and solid culture media. Results: Centella asiatica and Citrus grandis showed the same phytochemical profile, with the presence of alkaloids, terpenoids, steroids and polyphenols such as: flavonoids, free quinones, anthocyanins, leuco-anthocyanins and tannins. Zanthoxylum gilletii extract showed similar profile with the absence of anthocyanins and leucoanthocyanins. The polyphenolic extracts of both Centella asiati...
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Journal of Complementary and Alternative Medical Research, 2021
Medicinal plants are suppliers of molecules used in both modern and traditional therapy. One of t... more Medicinal plants are suppliers of molecules used in both modern and traditional therapy. One of these plants is Azadirachta Indica (also known as the neem tree).Originally from Asia (India), this plant is currently widespread and cultivated in several countries in the world, including in Africa, because of its extraordinary therapeutic properties. A survey carried out on the Internet revealed that A. indica contains various secondary metabolites such as: Azadirone, Nimocimol, Azadiradione, Epoxyazadiradione, nimbinin, salannin, nimbanal, salannol acetate, nimbandiol, tannins, saponins, cardiac glycosides, steroids, gedunin, nimbinene, nimbolide, mahmoodin, margolonone, isomargolonone, azadirachtin, epicatechin, catechin, phenols, alkaloids, flavonoids, steroids, triterpenoids, anthraquinone, anthocyanins. The main structures of these different molecules were drawn using the ChemBioDraw Ultra 12.0 software package. As a result, it has been demonstrated that these compounds confer sev...
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International Journal of Biological and Chemical Sciences, 2009
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SARS-CoV-2 is the causative agent of the COVID-19 disease. Pathophysiologically, high levels of p... more SARS-CoV-2 is the causative agent of the COVID-19 disease. Pathophysiologically, high levels of proinflammatory cytokines in the serum of SARS-CoV-2 patients are reported, which is so-called the cytokine storm. In this study, molecular docking calculations of six bioactive compounds from Passiflora edulis with anti-inflammatory activity in interaction with the main protease of SARS-CoV-2 were performed, and their pharmacokinetic properties were predicted. The results of their molecular simulations and the ADME-T profiles of each ligand (Absorption, Distribution, Metabolism, Excretion and Toxicity) suggest their use as potential treatment for SARS-CoV-2. Among the six investigated compounds in which four flavonoids and two alkaloids, the best docked ligands are quercetin (-8.2 kcal/mol), chrysin (-8.0 kcal/mol), kaempferol (-7.9 kcal/mol) and luteolin (-7.7 kcal/mol), both flavonoids compounds. Their pharmacokinetic studies using SwissADME, preADMET and pkCSM Web servers establish th...
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European Journal of Nutrition & Food Safety, 2020
Background and Aim: Condiment plants are not only a source of food, flavors or food additives but... more Background and Aim: Condiment plants are not only a source of food, flavors or food additives but also antivirals. The aim of the present work consisted in compiling ethno-botanical, phytochemical, toxicological and biological activities literature data reported on some species of the Solanum genus, precisely their antiviral potential. Methodology: The literature review was based mainly on the usual databases such as PubMed, PubMed Central, Science Direct, SCIELO, DOAJ, Science alert and Google scholar. Results: The ethnobotanical studies show that Solanum species are used in traditional medicine for the treatment of several ailments, particularly those affecting the respiratory system. With regard to studies on their bioactivity, the literature indicates that the Solanum genus is full of species used in food and/or traditional medicine, in most cases presenting several biological properties such as antiviral potential. Among the viruses sensitive to extracts from Solanum species, a...
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Asian Journal of Biology, 2020
Aim: The main aim of the present study is to validate the bioactivity of O. basilicum, a medicina... more Aim: The main aim of the present study is to validate the bioactivity of O. basilicum, a medicinal plant traditionally used to treat helminthiasis in DRC. Place and Duration of Study: Department of Chemistry, Science Faculty, University of Kinshasa, between June 2018 and March 2019. Methodology: Different parts (stems, leaves and flowers) of O. basilicum and specimens of earthworms of Benhamia rosea were collected and identified at University of Kinshasa. Micrographic examination was carried out using Biolux NV microscope and X-ray fluorescence method for mineral content determination. Radical scavenging activity was performed using the ABTS radical test. Results: Microscopic analysis of O. basilicum powder revealed various histological elements like crystalline fibres, sclerotic fibres, fragments of spiral vessels, pluricellular hairs and glandular hairs. Phytochemical screening in solution and by TLC revealed the presence of polyphenols (flavonoids, anthocyanins, saponins), alkalo...
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Papers by Damien Tshibangu