Archives of Industrial Hygiene and Toxicology, 2021
Exposure to environmental particulate matter (PM), outdoor air pollution in particular, has long ... more Exposure to environmental particulate matter (PM), outdoor air pollution in particular, has long been associated with adverse health effects. Today, PM has widely been accepted as a systemic toxicant showing adverse effects beyond the lungs. There are numerous studies, from those in vitro to epidemiological ones, suggesting various direct and indirect PM toxicity mechanisms associated with cardiovascular risks, including inflammatory responses, oxidative stress, changes in blood pressure, autonomic regulation of heart rate, suppression of endothelium-dependent vasodilation, thrombogenesis, myocardial infarction, and fibrinolysis. In addition to these and other health risks, considerations about air quality standards should include individual differences, lifestyle, and vulnerable populations such as children. Urban air pollution has been a major environmental issue for Turkey, and this review will also address current situation, research, and measures taken in our country.
Magnetic nanoparticles (MNPs) have been increasingly used for many years as MRI agents and for ge... more Magnetic nanoparticles (MNPs) have been increasingly used for many years as MRI agents and for gene delivery and hyperthermia therapy, although there have been conflicting results on their safety.
Mutation Research/Reviews in Mutation Research, 2011
The human buccal micronucleus cytome assay (BMCyt) is one of the most widely used techniques to m... more The human buccal micronucleus cytome assay (BMCyt) is one of the most widely used techniques to measure genetic damage in human population studies. Reducing protocol variability, assessing the role of confounders, and estimating a range of reference values are research priorities that will be addressed by the HUMN(XL) collaborative study. The HUMN(XL) project evaluates the impact of host factors, occupation, life-style, disease status, and protocol features on the occurrence of MN in exfoliated buccal cells. In addition, the study will provide a range of reference values for all cytome endpoints. A database of 5424 subjects with buccal MN values obtained from 30 laboratories worldwide was compiled and analyzed to investigate the influence of several conditions affecting MN frequency. Random effects models were mostly used to investigate MN predictors. The estimated spontaneous MN frequency was 0.74‰ (95% CI 0.52-1.05). Only staining among technical features influenced MN frequency, with an abnormal increase for non-DNA-specific stains. No effect of gender was evident, while the trend for age was highly significant (p<0.001). Most occupational exposures and a diagnosis of cancer significantly increased MN and other endpoints frequencies. MN frequency increased in heavy smoking (≥40cig/day, FR=1.37; 95% CI 1.03-.82) and decreased with daily fruit consumption (FR=0.68; 95% CI 0.50-0.91). The results of the HUMN(XL) project identified priorities for validation studies, increased the basic knowledge of the assay, and contributed to the creation of a laboratory network which in perspective may allow the evaluation of disease risk associated with MN frequency.
Kimyasal maddelerin güvenli kullanımı ile ilgili toplumda genel bilgi eksikliği olması, özellikle... more Kimyasal maddelerin güvenli kullanımı ile ilgili toplumda genel bilgi eksikliği olması, özellikle çocukları kimyasal maddeler konusunda bilinçlendirmenin gerekliliğini ortaya koymaktadır. Bu amaçla Avrupa Birliği Yaşam boyu Öğrenme Programı Leonardo da Vinci (LdV) Ortaklık Projeleri kapsamında “?ç ve dış ortam kimyasal maddelerin zararları konusunda çocukların farkındalıklarını arttırmak” adlı bir proje hazırlanmıştır. Proje için üç ülkedeki (Türkiye, Polonya, ?sveç) sekiz kurumdan oluşan disiplinler arası bir ekip oluşturulmuştur. Hazırlanacak eğitim materyalinin temel kavramlar, evimizdeki ilaçlar, ev içi temizlik ürünleri, pestisitler, plastikler, çevresel sigara dumanı ve karbonmonoksit başlıklarını içermesi planlanmış ve DVD ile öğretmenlere yönelik bir el kitabı hazırlanmıştır. Çalışmada ilköğretim 4. ve 5. sınıfa devam eden yaşları yaklaşık 10-12 arasında olan çocuklardan oluşan iki deney ve iki kontrol grubu yer almıştır. Araştırma sonucunda, ele alınan kimyasallar ve bunların kullanımına ilişkin, deney grubundaki öğrencilerin kontrol grubundaki öğrencilere göre son testte daha fazla doğru yanıt verdikleri elde edilmiştir. Etkileşimli bir süreçte kullanılacak bu öğretim materyalinin Fen ve Teknoloji dersi öğretim programlarındaki boşluğu doldurması ve çocukların daha bilinçli bireyler olarak gelişmelerine katkıda bulunması beklenmektedir.There is a need for raising the awareness of safe usage of chemicals in children due to the lack of information on this issue. For this purpose a project was developed titled as of “Raising awareness of children about harmful effects of indoor and outdoor chemicals” in the frame of European Union Lifelong Learning program Leonardo da Vinci (LDV) Partnership Projects. For this project, an interdisciplinary team was formed from eight institutions in three countries (Turkey, Poland and Sweden). The titles of the education material were composed of basic concepts, medicines at home, household cleaners, pesticides, plastics, environmental tobacco smoke and carbonmonoxide. A DVD and teachers’ manual were prepared including these subjects. The present study present information provided by the post test with both two experimental and two control groups after demonstration of the educational material (DVD) to 4th and 5th grade students aged between nearly 10 and 12. Results of the post test showed that students in the experimental group gave more correct answers than controls. The present educational material is expected to become a supplementary material for Science and Technology course and to contribute children’s to become more conscious individuals
Ankara Üniversitesi Eğitim Bilimleri Fakültesi Dergisi, 2013
Kimyasal maddelerin güvenli kullanımı ile ilgili toplumda genel bilgi eksikliği olması, özellikle... more Kimyasal maddelerin güvenli kullanımı ile ilgili toplumda genel bilgi eksikliği olması, özellikle çocukları kimyasal maddeler konusunda bilinçlendirmenin gerekliliğini ortaya koymaktadır. Bu amaçla Avrupa Birliği Yaşam boyu Öğrenme Programı Leonardo da Vinci (LdV) Ortaklık Projeleri kapsamında "Đç ve dış ortam kimyasal maddelerin zararları konusunda çocukların farkındalıklarını arttırmak" adlı bir proje hazırlanmıştır. Proje için üç ülkedeki (Türkiye, Polonya, Đsveç) sekiz kurumdan oluşan disiplinler arası bir ekip oluşturulmuştur. Hazırlanacak eğitim materyalinin temel kavramlar, evimizdeki ilaçlar, ev içi temizlik ürünleri, pestisitler, plastikler, çevresel sigara dumanı ve karbonmonoksit başlıklarını içermesi planlanmış ve DVD ile öğretmenlere yönelik bir el kitabı hazırlanmıştır. Çalışmada ilköğretim 4. ve 5. sınıfa devam eden yaşları yaklaşık 10-12 arasında olan çocuklardan oluşan iki deney ve iki kontrol grubu yer almıştır. Araştırma sonucunda, ele alınan kimyasallar...
Occupational exposure to the waste anaesthetic gases (WAGs) is a crucial problem for healthcare p... more Occupational exposure to the waste anaesthetic gases (WAGs) is a crucial problem for healthcare personnel. Cancer is among the potential long-term adverse effects of WAGs. The present occupational molecular epidemiology study was conducted in healthcare personnel (anaesthetists, nurses and technicians; n = 46), working in operating rooms (ORs; n = 34) and recovery units (RUs; n = 12) of the same hospital, to assess the genotoxicity risk of WAGs exposure. Twenty-one healthy available hospital staff allocated to other wards, without the history of working in ORs and RUs were the control group. A micronucleus test was carried out for peripheral blood lymphocytes (PBLs) and buccal epithelial cells (BECs). Exposure to the anaesthetics was assessed with sevoflurane concentrations and inorganic fluoride levels in post-shift urine samples of the healthcare staff. As an exposure marker, sevoflurane concentrations in ORs and RUs were measured using passive samplers. The micronuclei frequencie...
Archives of Industrial Hygiene and Toxicology, 2021
Exposure to environmental particulate matter (PM), outdoor air pollution in particular, has long ... more Exposure to environmental particulate matter (PM), outdoor air pollution in particular, has long been associated with adverse health effects. Today, PM has widely been accepted as a systemic toxicant showing adverse effects beyond the lungs. There are numerous studies, from those in vitro to epidemiological ones, suggesting various direct and indirect PM toxicity mechanisms associated with cardiovascular risks, including inflammatory responses, oxidative stress, changes in blood pressure, autonomic regulation of heart rate, suppression of endothelium-dependent vasodilation, thrombogenesis, myocardial infarction, and fibrinolysis. In addition to these and other health risks, considerations about air quality standards should include individual differences, lifestyle, and vulnerable populations such as children. Urban air pollution has been a major environmental issue for Turkey, and this review will also address current situation, research, and measures taken in our country.
Magnetic nanoparticles (MNPs) have been increasingly used for many years as MRI agents and for ge... more Magnetic nanoparticles (MNPs) have been increasingly used for many years as MRI agents and for gene delivery and hyperthermia therapy, although there have been conflicting results on their safety.
Mutation Research/Reviews in Mutation Research, 2011
The human buccal micronucleus cytome assay (BMCyt) is one of the most widely used techniques to m... more The human buccal micronucleus cytome assay (BMCyt) is one of the most widely used techniques to measure genetic damage in human population studies. Reducing protocol variability, assessing the role of confounders, and estimating a range of reference values are research priorities that will be addressed by the HUMN(XL) collaborative study. The HUMN(XL) project evaluates the impact of host factors, occupation, life-style, disease status, and protocol features on the occurrence of MN in exfoliated buccal cells. In addition, the study will provide a range of reference values for all cytome endpoints. A database of 5424 subjects with buccal MN values obtained from 30 laboratories worldwide was compiled and analyzed to investigate the influence of several conditions affecting MN frequency. Random effects models were mostly used to investigate MN predictors. The estimated spontaneous MN frequency was 0.74‰ (95% CI 0.52-1.05). Only staining among technical features influenced MN frequency, with an abnormal increase for non-DNA-specific stains. No effect of gender was evident, while the trend for age was highly significant (p<0.001). Most occupational exposures and a diagnosis of cancer significantly increased MN and other endpoints frequencies. MN frequency increased in heavy smoking (≥40cig/day, FR=1.37; 95% CI 1.03-.82) and decreased with daily fruit consumption (FR=0.68; 95% CI 0.50-0.91). The results of the HUMN(XL) project identified priorities for validation studies, increased the basic knowledge of the assay, and contributed to the creation of a laboratory network which in perspective may allow the evaluation of disease risk associated with MN frequency.
Kimyasal maddelerin güvenli kullanımı ile ilgili toplumda genel bilgi eksikliği olması, özellikle... more Kimyasal maddelerin güvenli kullanımı ile ilgili toplumda genel bilgi eksikliği olması, özellikle çocukları kimyasal maddeler konusunda bilinçlendirmenin gerekliliğini ortaya koymaktadır. Bu amaçla Avrupa Birliği Yaşam boyu Öğrenme Programı Leonardo da Vinci (LdV) Ortaklık Projeleri kapsamında “?ç ve dış ortam kimyasal maddelerin zararları konusunda çocukların farkındalıklarını arttırmak” adlı bir proje hazırlanmıştır. Proje için üç ülkedeki (Türkiye, Polonya, ?sveç) sekiz kurumdan oluşan disiplinler arası bir ekip oluşturulmuştur. Hazırlanacak eğitim materyalinin temel kavramlar, evimizdeki ilaçlar, ev içi temizlik ürünleri, pestisitler, plastikler, çevresel sigara dumanı ve karbonmonoksit başlıklarını içermesi planlanmış ve DVD ile öğretmenlere yönelik bir el kitabı hazırlanmıştır. Çalışmada ilköğretim 4. ve 5. sınıfa devam eden yaşları yaklaşık 10-12 arasında olan çocuklardan oluşan iki deney ve iki kontrol grubu yer almıştır. Araştırma sonucunda, ele alınan kimyasallar ve bunların kullanımına ilişkin, deney grubundaki öğrencilerin kontrol grubundaki öğrencilere göre son testte daha fazla doğru yanıt verdikleri elde edilmiştir. Etkileşimli bir süreçte kullanılacak bu öğretim materyalinin Fen ve Teknoloji dersi öğretim programlarındaki boşluğu doldurması ve çocukların daha bilinçli bireyler olarak gelişmelerine katkıda bulunması beklenmektedir.There is a need for raising the awareness of safe usage of chemicals in children due to the lack of information on this issue. For this purpose a project was developed titled as of “Raising awareness of children about harmful effects of indoor and outdoor chemicals” in the frame of European Union Lifelong Learning program Leonardo da Vinci (LDV) Partnership Projects. For this project, an interdisciplinary team was formed from eight institutions in three countries (Turkey, Poland and Sweden). The titles of the education material were composed of basic concepts, medicines at home, household cleaners, pesticides, plastics, environmental tobacco smoke and carbonmonoxide. A DVD and teachers’ manual were prepared including these subjects. The present study present information provided by the post test with both two experimental and two control groups after demonstration of the educational material (DVD) to 4th and 5th grade students aged between nearly 10 and 12. Results of the post test showed that students in the experimental group gave more correct answers than controls. The present educational material is expected to become a supplementary material for Science and Technology course and to contribute children’s to become more conscious individuals
Ankara Üniversitesi Eğitim Bilimleri Fakültesi Dergisi, 2013
Kimyasal maddelerin güvenli kullanımı ile ilgili toplumda genel bilgi eksikliği olması, özellikle... more Kimyasal maddelerin güvenli kullanımı ile ilgili toplumda genel bilgi eksikliği olması, özellikle çocukları kimyasal maddeler konusunda bilinçlendirmenin gerekliliğini ortaya koymaktadır. Bu amaçla Avrupa Birliği Yaşam boyu Öğrenme Programı Leonardo da Vinci (LdV) Ortaklık Projeleri kapsamında "Đç ve dış ortam kimyasal maddelerin zararları konusunda çocukların farkındalıklarını arttırmak" adlı bir proje hazırlanmıştır. Proje için üç ülkedeki (Türkiye, Polonya, Đsveç) sekiz kurumdan oluşan disiplinler arası bir ekip oluşturulmuştur. Hazırlanacak eğitim materyalinin temel kavramlar, evimizdeki ilaçlar, ev içi temizlik ürünleri, pestisitler, plastikler, çevresel sigara dumanı ve karbonmonoksit başlıklarını içermesi planlanmış ve DVD ile öğretmenlere yönelik bir el kitabı hazırlanmıştır. Çalışmada ilköğretim 4. ve 5. sınıfa devam eden yaşları yaklaşık 10-12 arasında olan çocuklardan oluşan iki deney ve iki kontrol grubu yer almıştır. Araştırma sonucunda, ele alınan kimyasallar...
Occupational exposure to the waste anaesthetic gases (WAGs) is a crucial problem for healthcare p... more Occupational exposure to the waste anaesthetic gases (WAGs) is a crucial problem for healthcare personnel. Cancer is among the potential long-term adverse effects of WAGs. The present occupational molecular epidemiology study was conducted in healthcare personnel (anaesthetists, nurses and technicians; n = 46), working in operating rooms (ORs; n = 34) and recovery units (RUs; n = 12) of the same hospital, to assess the genotoxicity risk of WAGs exposure. Twenty-one healthy available hospital staff allocated to other wards, without the history of working in ORs and RUs were the control group. A micronucleus test was carried out for peripheral blood lymphocytes (PBLs) and buccal epithelial cells (BECs). Exposure to the anaesthetics was assessed with sevoflurane concentrations and inorganic fluoride levels in post-shift urine samples of the healthcare staff. As an exposure marker, sevoflurane concentrations in ORs and RUs were measured using passive samplers. The micronuclei frequencie...
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