Objectives: Rotator cuff tears are a common cause of shoulder pain and functional deficits. Altho... more Objectives: Rotator cuff tears are a common cause of shoulder pain and functional deficits. Although surgical repair is often able to restore function and resolve pain, high rates of postoperative structural failures have been reported. To improve the outcomes and reduce re-tear rates biologic tissue scaffolds have been used to augment and reinforce the primary tendon repair by providing mechanical support of the initial repair and ideally improving the rate and/or quality of biological healing at the tendon-bone interface. Demineralised bone fibers (DBF) are bone collagen and can be formed into a patch providing a scaffold and inductive bone morphogenetic proteins known to facilitate healing. This study evaluated the in vivo response of human DBF Patches (hDBF-P) as an onlay over the infraspinatus tendon (IST) and at the tendon-bone interface in an ovine model. Methods: The hDBF-P was characterised using stereozoom (Figure 1A) and environment electron microscopy (Figure 1B). The os...
Page 1. 1 Carbon-fiber heating systems for maintaining core body temperature of anesthetized smal... more Page 1. 1 Carbon-fiber heating systems for maintaining core body temperature of anesthetized small animals during microSPECT/CT imaging Authors Carmen C. Taylor1, 2, William Barber1,3, Vickie Yi Zhang1, Bruce H. Hasegawa1, 2 ...
AbstractSmall animal imaging relies on cone-beam reconstruction geometries to achieve high spati... more AbstractSmall animal imaging relies on cone-beam reconstruction geometries to achieve high spatial resolution for both microSPECT and microCT. However, normal circular-orbit cone-beam geometries offer a restricted field of view which for microSPECT has nonuniform ...
Penetrating Radiation Systems and Applications VI, 2004
Cardiac function is an important physiological parameter in preclinical studies. Nuclear cardiac ... more Cardiac function is an important physiological parameter in preclinical studies. Nuclear cardiac scans are a standard of care for patients with suspected coronary artery occlusions and can assess perfusion and other physiological functions via the injection of radiotracers. In addition, correlated acquisition of nuclear images with electrocardiogram (ECG) signals can provide myocardial dynamics, which can be used to assess the
Penetrating Radiation Systems and Applications VI, 2004
ABSTRACT Space-based gamma-ray spectrometers utilize active anticoincidence shielding to reduce t... more ABSTRACT Space-based gamma-ray spectrometers utilize active anticoincidence shielding to reduce the background caused by charged-particle interactions. Shielding improves the performance of gamma-ray spectrometers by reducing the effect of charged particle interactions which can not be distinguished from true gamma-ray interactions by the spectrometer. Active shields produce a blanking signal when a charged particle is detected, so that the signal from the spectrometer can be ignored during the spectrometer's charged-particle interaction. Anticoincidence shielding for space-born gamma-ray detectors requires a cylindrical-shell geometry and charged-particle sensitivity. To reduce the size, weight, and cost of the shielding we utilize a new direct-conversion charged-particle detector material, polycrystalline mercuric iodide. We present the results from planar film growth techniques for the particle-counting detection capabilities necessary for anti-coincidence shielding. We also show that films with similar detection properties were grown on curved substrates with the size and curvature needed to surround space-based spectrometer main detectors.
... Computed Tomography with a Multi-Energy-Window Photon Counting X-ray Detector Xiaolan Wanga, ... more ... Computed Tomography with a Multi-Energy-Window Photon Counting X-ray Detector Xiaolan Wanga, Jingyan Xua, Katsuyuki Taguchia, Bradley E. Pattb, Douglas J. Wagenaarb, and Eric C. Frey*a ... REFERENCES [1] JIMurungi, S.Thiam, RETrace, JWRobinson, and IMWarner ...
IEEE Nuclear Science Symposuim & Medical Imaging Conference, 2010
Abstract Conventional x-ray detectors integrate the photon energy flux, losing individual photon ... more Abstract Conventional x-ray detectors integrate the photon energy flux, losing individual photon energy information. By contrast, energy resolved photon-counting x-ray detectors (PCXDs) count photons in energy windows, thus retaining some energy information. This ...
2003 IEEE Nuclear Science Symposium. Conference Record (IEEE Cat. No.03CH37515)
We have developed and tested a pixelated detector for pinhole SPECT. The 80×80 detector has a pix... more We have developed and tested a pixelated detector for pinhole SPECT. The 80×80 detector has a pixel size of 2.5×2.5 mm2 and incorporates the room-temperature solid-state semiconductor CdZnTe which offers direct charge conversion and good stopping power for radionuclides ...
The use of miniaturized XRF instrumentation for in-vivo applications imposes specific requirement... more The use of miniaturized XRF instrumentation for in-vivo applications imposes specific requirements on the choice of detector technologies that can be used, and on the design and construction of the instrumentation. One critical issue is the temperature of operation of the detector. Substantial cooling cannot be tolerated because of the difficulties of extracting the heat from a small probe. Another
Objectives: Rotator cuff tears are a common cause of shoulder pain and functional deficits. Altho... more Objectives: Rotator cuff tears are a common cause of shoulder pain and functional deficits. Although surgical repair is often able to restore function and resolve pain, high rates of postoperative structural failures have been reported. To improve the outcomes and reduce re-tear rates biologic tissue scaffolds have been used to augment and reinforce the primary tendon repair by providing mechanical support of the initial repair and ideally improving the rate and/or quality of biological healing at the tendon-bone interface. Demineralised bone fibers (DBF) are bone collagen and can be formed into a patch providing a scaffold and inductive bone morphogenetic proteins known to facilitate healing. This study evaluated the in vivo response of human DBF Patches (hDBF-P) as an onlay over the infraspinatus tendon (IST) and at the tendon-bone interface in an ovine model. Methods: The hDBF-P was characterised using stereozoom (Figure 1A) and environment electron microscopy (Figure 1B). The os...
Page 1. 1 Carbon-fiber heating systems for maintaining core body temperature of anesthetized smal... more Page 1. 1 Carbon-fiber heating systems for maintaining core body temperature of anesthetized small animals during microSPECT/CT imaging Authors Carmen C. Taylor1, 2, William Barber1,3, Vickie Yi Zhang1, Bruce H. Hasegawa1, 2 ...
AbstractSmall animal imaging relies on cone-beam reconstruction geometries to achieve high spati... more AbstractSmall animal imaging relies on cone-beam reconstruction geometries to achieve high spatial resolution for both microSPECT and microCT. However, normal circular-orbit cone-beam geometries offer a restricted field of view which for microSPECT has nonuniform ...
Penetrating Radiation Systems and Applications VI, 2004
Cardiac function is an important physiological parameter in preclinical studies. Nuclear cardiac ... more Cardiac function is an important physiological parameter in preclinical studies. Nuclear cardiac scans are a standard of care for patients with suspected coronary artery occlusions and can assess perfusion and other physiological functions via the injection of radiotracers. In addition, correlated acquisition of nuclear images with electrocardiogram (ECG) signals can provide myocardial dynamics, which can be used to assess the
Penetrating Radiation Systems and Applications VI, 2004
ABSTRACT Space-based gamma-ray spectrometers utilize active anticoincidence shielding to reduce t... more ABSTRACT Space-based gamma-ray spectrometers utilize active anticoincidence shielding to reduce the background caused by charged-particle interactions. Shielding improves the performance of gamma-ray spectrometers by reducing the effect of charged particle interactions which can not be distinguished from true gamma-ray interactions by the spectrometer. Active shields produce a blanking signal when a charged particle is detected, so that the signal from the spectrometer can be ignored during the spectrometer's charged-particle interaction. Anticoincidence shielding for space-born gamma-ray detectors requires a cylindrical-shell geometry and charged-particle sensitivity. To reduce the size, weight, and cost of the shielding we utilize a new direct-conversion charged-particle detector material, polycrystalline mercuric iodide. We present the results from planar film growth techniques for the particle-counting detection capabilities necessary for anti-coincidence shielding. We also show that films with similar detection properties were grown on curved substrates with the size and curvature needed to surround space-based spectrometer main detectors.
... Computed Tomography with a Multi-Energy-Window Photon Counting X-ray Detector Xiaolan Wanga, ... more ... Computed Tomography with a Multi-Energy-Window Photon Counting X-ray Detector Xiaolan Wanga, Jingyan Xua, Katsuyuki Taguchia, Bradley E. Pattb, Douglas J. Wagenaarb, and Eric C. Frey*a ... REFERENCES [1] JIMurungi, S.Thiam, RETrace, JWRobinson, and IMWarner ...
IEEE Nuclear Science Symposuim & Medical Imaging Conference, 2010
Abstract Conventional x-ray detectors integrate the photon energy flux, losing individual photon ... more Abstract Conventional x-ray detectors integrate the photon energy flux, losing individual photon energy information. By contrast, energy resolved photon-counting x-ray detectors (PCXDs) count photons in energy windows, thus retaining some energy information. This ...
2003 IEEE Nuclear Science Symposium. Conference Record (IEEE Cat. No.03CH37515)
We have developed and tested a pixelated detector for pinhole SPECT. The 80×80 detector has a pix... more We have developed and tested a pixelated detector for pinhole SPECT. The 80×80 detector has a pixel size of 2.5×2.5 mm2 and incorporates the room-temperature solid-state semiconductor CdZnTe which offers direct charge conversion and good stopping power for radionuclides ...
The use of miniaturized XRF instrumentation for in-vivo applications imposes specific requirement... more The use of miniaturized XRF instrumentation for in-vivo applications imposes specific requirements on the choice of detector technologies that can be used, and on the design and construction of the instrumentation. One critical issue is the temperature of operation of the detector. Substantial cooling cannot be tolerated because of the difficulties of extracting the heat from a small probe. Another
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