Papers by Biochemistry Ms. Sangeetha Sathyanarayanan
Type 2 diabetes mellitus once considered as a metabolic disorder characterized by chronic elevati... more Type 2 diabetes mellitus once considered as a metabolic disorder characterized by chronic elevation in both fasting and postprandial levels is now established as a polygenic disease involving several etiological factors. Alpha amylase and alpha glucosidase inhibitors are used to achieve greater control over hyperglycemia in type 2 diabetes mellitus. Polyherbal preparations with various active principles and properties have been used in different regions and cultures to treat a wide range of human diseases. In the present study an attempt has been made to evaluate the antioxidant and in vitro antidiabetic efficacy of GOA 111, a mixture of Gymnema sylvestre, Ocimum sanctum and Azadirachta indica in the ratio of 1:1:1. Polyherbal formulation was analyzed for phytochemicals. The antioxidant potential of GOA 111 was determined using DPPH, ABTS assay. The effect of GOA 111 on the activities of alpha glucosidase and alpha amylase were studied. GOA 111 contains Alkaloids, flavonoids, tannin...
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Research journal of pharmacy and technology, Feb 26, 2022
Objective: The objective of the present work is to perfom in silico docking analysis against the ... more Objective: The objective of the present work is to perfom in silico docking analysis against the molecular targets involved in diabetes mellitus using active compounds from Polyherbal powder. Materials and methods: Polyherbal powder is prepared using Gymnema sylvestre, Ocimum sanctum and Azadirachta indica. Three compounds from the polyherbal powder (identified using HR-LCMS) were used for the docking against the targets (α-glucosidase, α amylase, peroxisome proliferator activated receptor gamma). Docking was performed using Autodock 4.2 software. Pymol was used for the visualization of the docking result files. Results: Binding energy of Usnic acid (-4.25 kcal/mol for 1PRG, -6.69 kcal/mol for 3WY1, -5.72 kcal/mol for 4GQQ) was low as that of standard drug Metformin (-5.07 kcal/mol for 1PRG, -6.3 kcal/mol for 3WY1, -4.02 kcal/mol for 4GQQ). Conclusion: The polyherbal powder containing the lead compounds can be used for the treatment of diabetes mellitus.
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Papers by Biochemistry Ms. Sangeetha Sathyanarayanan