Papers by Aysu Yurdasiper
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The aim of this study was to develop a new extended release capsules of indomethacin. The formula... more The aim of this study was to develop a new extended release capsules of indomethacin. The formulation has been prepared to enhance its dissolution which could provide better oral absorption of indomethacin (IND). Therefore, the effects of the component nature, their proportion in the release rate and the dissolution mechanism were investigated. Extended release capsules of IND were prepared by physical mixing using plasdone (PVP K-90) and compritol-HD5 ATO (Comp) at various drug-polymer ratios. Flow properties of the physical mixtures were evaluated by calculation of the Carr’s index, angle of repose and Hausner ratio. According to the United States Pharmacopeial (USP) drug release criteria of IND extend release capsules, the release results of formulations F2 and F3 were found to be similar to the USP (P < 0.05). Certain mathematical models were used for evaluation of release profiles and the results supported by multiple regression analysis. It was observed that the best-fit mo...
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Journal of Dr. Behcet Uz Children s Hospital, 2021
Objective: Allergic rhinitis (AR) is an inflammatory disease of the nasal mucosa mediated by IgE ... more Objective: Allergic rhinitis (AR) is an inflammatory disease of the nasal mucosa mediated by IgE after exposure to an allergen. The most well known related comorbidity of AR is asthma. This study was planned due to the need for an animal model for studies on AR-asthma coexistence. In this study, the frequency of AR accompanying in the asthma model created in mice,and the usability of the related model in AR studies will be investigated. Methods: In our study, 6-8 week-old, 18-20 g BALB/c mice were used. Chicken egg ovalbumin (OVA Grade V, Sigma) was administered through intraperitoneal (IP) route at doses of 10 μg on days 0 and 14. Mice were exposed to aerosolized 2.5% ovalbumin solution in sterile saline for 30 minutes 3 days a week for 8 weeks, starting 7 days after the last IP administration (21st day). After exposure to OVA, mice were observed for typical signs of AR including sneezing, runny nose, and nasal itching. The final diagnosis of AR was made by histopathological examin...
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Emerging Nanotechnologies in Immunology, 2018
Abstract Inhalation therapy which is fundamentally used for the treatment of respiratory disease ... more Abstract Inhalation therapy which is fundamentally used for the treatment of respiratory disease has been used for over 4000 years. Pulmonary drug delivery is a significant research area affecting the treatment of diseases including asthma, chronic obstructive pulmonary disease as well as cystic fibrosis (CF). Solid colloidal particles which are nanoparticles are ranging in size from 10 to 1000 nm. The particles in question can be made from biodegradable and biocompatible biomaterials. The principles which are expected to be active such as drugs of oligonucleotides can be adsorbed, encapsulated, or covalently attached to their surface or into their matrix. In vitro and in vivo studies have exhibited that nanoparticles are capable carrier systems meant for drug targeting strategies.
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Journal of Research in Pharmacy, 2018
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Nanomedicine: Nanotechnology, Biology and Medicine, 2018
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Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, 2016
Pulmonary tract is one of the oldest routes used for administration of drugs. During the past dec... more Pulmonary tract is one of the oldest routes used for administration of drugs. During the past decade, the lung has been very attractive for achieving systemic and local absorption of various drugs, particularly for those drugs that exhibit poor bioavailability when administered by the oral or parenteral route. Polymers are considered to be high interest because of their greater capability to encapsulate drugs to prolong the effect of drugs. They have been used to make drug delivery systems such as nanoparticles and microparticles. Natural and synthetic polymers have been studied substantially for pulmonary drug delivery to obtain controlled drug delivery. The physicochemical characteristics of the polymers used in dry powders are potently fundamental for increasing the performance of the inhalation system. In this entry we focus on the properties of natural and synthetic polymers in dry powder inhaler systems and review their application in inhalation drug delivery systems.
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Journal of Microencapsulation, 2015
Nebivolol (NB)-loaded solid lipid nanoparticles (SLNs) were prepared and modified with chitosan o... more Nebivolol (NB)-loaded solid lipid nanoparticles (SLNs) were prepared and modified with chitosan oligosaccharide lactate (COL) and polyethylene glycol (PEG) stearate for improvement of its oral bioavailability. Compritol, poloxamer and lecithin were used for the preparation of SLNs by homogenisation method. After in vitro characterisation effect of lipase, pepsin, or pancreatin on degradation and release rate were investigated. Cytotoxicity and permeation were studied on Caco-2 cells. As COL concentration increased in SLNs, size and zeta potential increased. PEG concentration was reversely proportional to particle size with no change in zeta potential. Encapsulation efficiencies (EEs) were determined as 84-98%. DSC confirmed solubilisation of NB in lipid matrix. A sustained release with no burst effect was determined. The presence of enzymes affected the release. SLNs did not reveal cytotoxicity and highest permeability was obtained with PEG modification. PEG-modified SLNs could be offered as a promising strategy for oral delivery of NB.
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In this paper, different formulation types of microparticulate systems such as beads, microbeads,... more In this paper, different formulation types of microparticulate systems such as beads, microbeads, microspheres and microsponges using to special attention chitosan, alginate and eudragit RS 100 are reviewed. Chitosan and alginates are natural, anionic or cationic, biocompatible, biodegredable and non-toxic polymers. They have excellent potential for pharmaceutical and biopharmaceutical applications. Eudragit RS is an acrylic copolymer and it has well-established mucoadhesive characteristics. It is still being used as a sustained release coating materials in pharmaceutical field. Various techniques used for preparing chitosan, alginate and eudragit RS microparticles have also been reviewed. This review also includes non steoridal antiinflammatory drug (NSAID) microparticle formulations which have been prepared with these polymers to minimize side effects and to obtain controlled release drug delivery systems. Moreover, literatures and patents underline a widespread use of alginate, c...
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The aim of this study was to develop a new extended release capsules of indomethacin. The formula... more The aim of this study was to develop a new extended release capsules of indomethacin. The formulation has been prepared to enhance its dissolution which could provide better oral absorption of indomethacin (IND). Therefore, the effects of the component nature, their proportion in the release rate and the dissolution mechanism were investigated. Extended release capsules of IND were prepared by physical mixing using plasdone (PVP K-90) and compritol-HD5 ATO (Comp) at various drug-polymer ratios. Flow properties of the physical mixtures were evaluated by calculation of the Carr's index, angle of repose and Hausner ratio. According to the United States Pharmacopeial (USP) drug release criteria of IND extend release capsules, the release results of formulations F2 and F3 were found to be similar to the USP (P < 0.05). Certain mathematical models were used for evaluation of release profiles and the results supported by multiple regression analysis. It was observed that the best-fi...
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Patenting Nanomedicines, 2012
Oral delivery is the most preferred way especially for chronic administration of drugs, due to pa... more Oral delivery is the most preferred way especially for chronic administration of drugs, due to patient convenience and compliance. Hence, it remains as an important and immense segment in the drug market. However, many drug molecules belong to Biopharmaceutics classification systems (BCS) class II (poorly soluble and permeable) and class IV (poorly soluble and impermeable), resulting in low bioavailability, which is the most important limitation of oral delivery. Nanosizing of drugs can lead to a dramatic increase in oral absorption and subsequent bioavailability. Possible factors affecting the transport of these nano carriers across gastrointestinal mucosa are size reduction and surface properties that modify the non-specific or targeted uptake by enterocytes and/or M cells. Benefits of nano sizing can be listed as reduction in variability of absorption, improved absorption for higher doses and rapid formulation development. Therefore, many nanosized systems have been formulated for oral delivery. This chapter presents the requirements in the field of oral delivery and describes the design, characterization and application of various nanosized formulations, such as, vesicular, micellar and particulate systems.
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ABSTRACT . Salvia species have been mainly studied for essential oils; among them Salvia tomentos... more ABSTRACT . Salvia species have been mainly studied for essential oils; among them Salvia tomentosa Mill. has been commonly used for various activities. Finding novel formulations for application of essential oils has been a concern of the field. In this study, organogels of essential oil of Salvia tomentosa have been in-vestigated with a novel preparation method. The uniformity, antibacterial, antifungal activity and antioxi-dant properties of Salvia tomentosa essential oil and its organogel formulation were evaluated. According to the results, it can be stated that formulation in C974 organogels was successfully prepared very fast with PEG 400 under microwave irradiation. The NMR and GC/MS studies confirmed the unchanged structure of essential oil. TEAC and antimicrobial activity studies showed the efficiency in the organogels. Formulation prepared can be used for antimicrobial and antioxidant purposes in topical drug delivery. The suggested method is suitable for scale-up and a process like that should be time and energy saving. INTRODUCTION Essential oils have been used in various in-dustries like food, drug and perfumery 1 . Lami-aceae family has been extensively studied for essential oils 2-4 . Salvia is an important genus of this family with 95 species and an endemism ra-tio of 50% in Turkey 5 . They produce high di-versity of active secondary metabolites 6 so compiled as a medicinal plant included in WHO Monographs on Selected Medicinal Plants, ES-COP Monographs and European Pharmacopeia. Among them Salvia tomentosa Mill. has been commonly used to treat cold, flu, and tonsillitis 7 . Besides, the species have been investigated for antioxidant 8,9 , insecticidal 10 , antibacterial 11,12 , antimycobacterial 13 , antiprotozoal 14 activi-ties with promising results. On the other hand, the plant has been analyzed to a great extent for essential oil constituents 9,15 as well as flavones, diterpenoids and triterpenes 16-18 . Essential oils are complex natural com-pounds with various usages 19 . Finding novel formulations for application is a concern of the field. Since they do not solubilize in the aque-ous media, their formulation is a challenge. Hy-drogels which are usually prepared using Car-bopols in industry are developed as carriers for topical applications of various substances. Car-bopols are very high molecular weight polymers of acrylic acid and neutralization with a base-like triethanolamine is required to form strong hydrogels 20 . However, these neutralization agents may interact with many substances espe-cially antioxidants. Besides, essential oils are not miscible systems with hydrogels 21 . The organogels are defined as bi-continuous systems made from gelators and apolar solvents. They do not always have water molecules, hy-drophilic water-miscible co-solvents can be used to produce organogels captured within the self-assembled structures of the gelator 22 . In this study organogels of essential oil of Salvia
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Clinical and Experimental Health Sciences, 2021
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The aim of this study was to develop a new extended release capsules of indomethacin. The formula... more The aim of this study was to develop a new extended release capsules of indomethacin. The formulation has been prepared to enhance its dissolution which could provide better oral absorption of indomethacin (IND). Therefore, the effects of the component nature, their proportion in the release rate and the dissolution mechanism were investigated. Extended release capsules of IND were prepared by physical mixing using plasdone (PVP K-90) and compritol-HD5 ATO (Comp) at various drug-polymer ratios. Flow properties of the physical mixtures were evaluated by calculation of the Carr’s index, angle of repose and Hausner ratio. According to the United States Pharmacopeial (USP) drug release criteria of IND extend release capsules, the release results of formulations F2 and F3 were found to be similar to the USP (P < 0.05). Certain mathematical models were used for evaluation of release profiles and the results supported by multiple regression analysis. It was observed that the best-fit model to determine the mechanism of the formulation which has shown the highest release was Higuchi square-root of time model (r2 = 0.969). According to the dissolution results, dissolution efficiency, relative dissolution rate and mean dissolution time were also evaluated. The results of the study indicated that new extended release hard gelatin capsules can be a promising alternative for the other oral formulations of IND
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Papers by Aysu Yurdasiper