Papers by Alena Buretić-tomljanović
Psychiatria Danubina, 2007
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Prostaglandins Leukotrienes and Essential Fatty Acids, Jun 1, 2017
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Archives of Psychiatry Research
An interaction between smoking and antipsychotic medications could potentially affect treatment e... more An interaction between smoking and antipsychotic medications could potentially affect treatment efficacy and promote metabolic side effects. We investigated the contribution of smoking status towards Positive and Negative Syndrome Scale (PANSS) scores and metabolic syndrome- related parameters (plasma lipid and glucose concentrations, and body mass index) among two groups of unmedicated patients with psychosis from the Croatian population: antipsychotic-naïve first-episode patients and nonadherent chronic patients. Previous data are inconsistent regarding the effects of smoking on clinical psychopathology among antipsychotic-naïve or minimally medicated patients with first-episode psychosis, and no studies have examined the potential influence of smoking on clinical psychopathology and metabolic parameters among nonadherent patients with chronic psychosis. Information about smoking status and antipsychotic nonadherence was obtained via auto-anamnestic and hetero-anamnestic informati...
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Psihološki razvoj čovjeka, 2008
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European Journal of Human Genetics, vol 13 - suppl 1, 2005
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Medicina-buenos Aires, 2014
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Objectives: It is hypothesized that rare structural variants in the human genome might contribute... more Objectives: It is hypothesized that rare structural variants in the human genome might contribute to schizophrenia and other neuropsychiatric disorders. Findings: Structural variation in the human genome such as deletions, duplications, and inversions, that alter gene dosage, might explain genetic contributions to normal variability of complex traits, but also to developmental anomalies and diseases. Large (>1 Mb) gene copy number variations (CNVs) are often associated with higher penetrance and more severe clinical features. Structural genomic rearrangements in schizophrenia are thought to preferentially disrupt genes that might be involved in nervous system development and function. Several studies have reported higher prevalence of rare CNVs in patients with schizophrenia compared to healthy comparison groups. Although a great majority of CNVs detected in schizophrenia represent rare and unique events, some of them appear recurrently: 22q11.2, 1q21.1, 2p16.3, and 15q13.3 delet...
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Objective: Schizophrenia patients are often smokers which make them an interesting group to study... more Objective: Schizophrenia patients are often smokers which make them an interesting group to study the etiology of nicotine dependence. We investigated the relationship between the rs10798059 (BanI) and rs4375 polymorphisms in phospholipase A2 (PLA2)G4A and PLA2G6 genes and the risk of nicotine dependence in Croatian schizophrenia patients. We also tested whether interactions between these polymorphic variants and smoking status might contribute to disease onset and scores for the Positive and Negative Syndrome Scale (PANSS). Patients and methods: Genotyping was performed for 263 patients by polymerase chain reaction. Results: There were no significant differences in the distribution of PLA2G4A genotypes and alleles in patients according to smoking status and no PLA2G4A genotype-smoking interaction on disease onset or PANSS. A significant overrepresentation of PLA2G6-CC homozygous and PLA2G6-CT heterozygous genotypes was detected in male nonsmokers compared to smokers (χ2=3.03, p=0.0...
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U cilju istraživanja etiologije reproduktivnih poremecaja u nasoj populaciji je analiziran 121 pa... more U cilju istraživanja etiologije reproduktivnih poremecaja u nasoj populaciji je analiziran 121 par (242 osobe) s razlicitim poremecajima reprodukcije. prema klinickoj dijagnozi svrstani su u sest skupina: parovi s jednim ili dva spontana pobacaja (46), s tri ili vise spontanih pobacaja (18), spontanim pobacajem i mrtvorođenim i/ili malformiranim djetetom (6), mrtvorođenim i/ili malformiranim djetetom bez spontanih pobacaja (25), missed abortion ili blighted ovum (13), te bracnim sterilitetom (13). Kromosomi supružnika analizirani su GTG metodom pruganja. Utvrđeno je 16 kromosomskih aberacija (13, 2%), 12 strukturnih i 4 numericke. Od strukturnih aberacija utvrđeno je 7 reciprocnih translokacija, 4 pericentricne inverzije kromosoma 9 i jedna Robertsonova translokacija. Od numerickih aberacija utvrđen je mozaicizam gonosoma X s 1%-5% aneuploidnih stanica u tri slucaja (46, XX/47, XXX ; 46, XX/45, X ; 46, XX/45, X/48, XXXX) i jedna gonosomska aneuploidija 47, XXY. Najveca ucestalost kromosomskih aberacija utvrđena je u parova s uputnom dijagnozom bracnog steriliteta (23, 1%). Ucestalost aberacija u 70 parova sa spontanim pobacajima, sa ili bez mrtvorođenog i/ili malformiranog potomstva, iznosi 15, 7%. U parova s mrtvorođenim ili malformiranim djetetom bez spontanih pobacaja ucestalost aberacija je 8%. Kromosomske aberacije nisu utvrđene u skupini s dijagnozom missed abortion ili blighted ovum. Kromosomske aberacije jednako su zastupljene u oba spola, a njihova ucestalost u nasem uzorku visa je od vrijednosti u literaturi (4, 3%-9, 6%).
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medicina, 2010
1Zavod za biologiju i medicinsku genetiku, Medicinski fakultet Sveučilita u Rijeci 2Zavod za sud... more 1Zavod za biologiju i medicinsku genetiku, Medicinski fakultet Sveučilita u Rijeci 2Zavod za sudsku medicinu, Medicinski fakultet Sveučilita u Rijeci 3Klinika za psihijatriju, Klinički bolnički centar, Rijeka 4Tomljanović doo, drutvo za obavljanje medicinske djelatnosti iz područja ...
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medicina, 2009
Ključne riječi: minor anomalije glave, minor anomalije lica, procjena simptoma PANSS-a ... Key wo... more Ključne riječi: minor anomalije glave, minor anomalije lica, procjena simptoma PANSS-a ... Key words: minor physical anomalies of the head, minor physical anomalies of the face, PANSS symptom scale evaluation ... Adresa za dopisivanje: *Prof. dr. sc. alena Buretić-tomljanović, dipl. ...
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American Journal of Reproductive Immunology, 1997
PROBLEM: Heteromorphism of constitutive heterochromatin is a stable evolutionary feature that is ... more PROBLEM: Heteromorphism of constitutive heterochromatin is a stable evolutionary feature that is thought to cause no phenotypic alterations. Nevertheless, the role of constitutive heterochromatin is still unknown. The instability of constitutive heterochromatin was generally restricted to T‐lymphocytes and was associated with variable immunodeficiency. The heterochromatin regions of chromosomes 1, 9, 16, and Y have been postulated to play a role in the immune response and during early embryo development.METHOD OF STUDY: To investigate a possible influence of constitutive heterochromatin in human reproductive ability, quantitative analysis of constitutive heterochromatin in human chromosomes 1, 9, 16, and Y was done. Thirty couples were divided into two groups, owing to the clinical heterogeneity of their reproductive disorders. The first group included couples with two or more spontaneous abortions as the only pregnancy outcomes, and the second group included couples with a stillbor...
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Annals of Human Biology, 2007
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Aim: Fertility rate of patients with schizophrenia is lower than in the general population. The c... more Aim: Fertility rate of patients with schizophrenia is lower than in the general population. The contributing factors are sex, marital status, reproductive age, socioeconomic, cultural, and genetic factors. In this work, we tested the possible genetic association between schizophrenia and lower fertility rate of male patients. Patients and methods: DNA samples taken from 105 male patients with clinical diagnosis of schizophrenia (according to DSM-IV criteria) and 100 control men were analysed for the presence of chromosome Y azoospermia factor (AZF) microdeletions. Six sequence tagged sites (STS) spanning AZFa-c region were analysed using two multiplex polymerase chain reactions: sY84, sY127, sY254, and sY86, sY134, sY255. STS-marker sY14 (Yp) and pseudoautosomal locus ZFX/ZFY were used as control loci in both reactions. Results: No evidence of AZF-microdeletions were found in both groups. Conclusion: Microdeletions of the chromosome Y AZF-region do not contribute to the risk or redu...
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hrcak.srce.hr
... facebook twitter delicious digg. Uvodnik. Urednička vizija za novu Medicinu. Saa Ostojić; Za... more ... facebook twitter delicious digg. Uvodnik. Urednička vizija za novu Medicinu. Saa Ostojić; Zavod za biologiju i medicinsku genetiku, Medicinski fakultet Sveučilita u Rijeci, Hrvatska. Puni tekst (Hrvatski) Str. 4 - 6 (pdf, 2.23 MB) downloads: 516. [Engleski]. ...
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hrcak.srce.hr
... Vlatka Lajnert; Katedra za stomatoloku protetiku, Medicinski fakultet Sveučilita u Rijeci R... more ... Vlatka Lajnert; Katedra za stomatoloku protetiku, Medicinski fakultet Sveučilita u Rijeci Renata Grić; Katedra za stomatoloku protetiku, Medicinski fakultet Sveučilita u Rijeci Daniela Kovačević Pavičić; Katedra za stomatoloku protetiku, Medicinski fakultet Sveučilita u ...
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Medicina Fluminensis
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Papers by Alena Buretić-tomljanović