Papers by Angela Maria Vicente Tavares
American Heart Journal, 2016
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International Journal of Sports Medicine, 2013
The acute administration of L-arginine (L-arg), a nitric oxide (NO) precursor, reduces lactate (L... more The acute administration of L-arginine (L-arg), a nitric oxide (NO) precursor, reduces lactate (LAC) concentration after exercise in healthy individuals. Lower concentration of L-arg may enhance the action of some inflammatory cytokines in HIV-1 infected patients. We tested the hypothesis that acute L-arg administration may reduce post-exercise blood LAC and inflammatory cytokines levels in HIV-infected patients. 10 HIV-infected men performed 2 maximal incremental cardiopulmonary exercise tests, separated by one week. 30 min before each test, patients received oral placebo or 20 g of L-arg, in random order. Blood LAC, tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-10 (IL-10) were measured before and up to 60 min after exercise. L-arg administration had no significant effect on exercise performance. Compared to placebo, L-arg administration reduced maximal post-exercise blood LAC from 8.7±0.6 to 6.9±0.4 mmol.L-1 (p<0.05). L-arg administration had no significant effect on TNF-alpha or IL-10 concentrations, but increased post-exercise IL-6 (placebo=19±3pg.mL-1; L-arg=63±8 pg.mL-1; p<0.05). In HIV-1 infected men, acute administration of L-arg reduces post-exercise blood LAC and increases IL-6 levels, suggesting the activation of the L-arg-NO pathway, with possible anti-inflammatory consequences.
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American Heart Journal, 2016
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Life Sciences, 2016
Right ventricle (RV) dysfunction post-myocardial infarction (MI) was associated with a worsened p... more Right ventricle (RV) dysfunction post-myocardial infarction (MI) was associated with a worsened prognosis. In this scenario, reactive oxygen species (ROS) are related with the progression from MI to heart failure. Previous work showed that thyroid hormones (TH) are cardioprotective after MI. This study aims to investigate the effect of T3 and T4 administration on oxidative stress and angiogenesis parameters in the RV after MI. Wistar rats were allocated into four groups: Sham-operated (SHAM), infarcted (AMI), sham-operated + TH (SHAMT), and infarcted+TH (AMIT). The treated groups received T3 (2μg/100g/day) and T4 (8μg/100g/day) by gavage for 26days. After this, echocardiographic analysis was performed and the RV was collected to western blot and biochemical analysis. Infarcted treated rats showed RV hypertrophy compared with AMI and SHAMT. Hydrogen peroxide levels were decrease and SOD activity and expression were increased in the infarcted treated rats. Besides that, the hormonal administration increased eNOS expression and prevented the reduction of VEGF levels in AMIT rats. In conclusion, TH seems to improve oxidative stress parameters, to promote physiological hypertrophy and to increase the expression of proteins involved with angiogenesis in the right heart.
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Apoptosis, 2015
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Molecular and Cellular Biochemistry, 2015
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Archives of Physiology and Biochemistry, 2020
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Journal of the American Society of Hypertension, 2015
Circulating adiponectin has been related to vascular diseases, but few studies examined the relat... more Circulating adiponectin has been related to vascular diseases, but few studies examined the relationship between plasma adiponectin and microvascular abnormalities among hypertensive individuals. We tested the association between plasma adiponectin level and retinal vessel calibers in patients with hypertension.This study included 172 patients with confirmed hypertension, aged 18-80 years. Subjects with recent cardiovascular events, advanced heart failure and end-stage renal disease were excluded. Arteriolar and venular calibers were measured in retinographies using a microdensitometric image-processing method. Blood pressure was measured using a validated oscillometric device. We observed a statistically significant inverse association between plasma adiponectin and arteriolar caliber among participants aged 60 years or older after controlling for confounders (Adjusted β = -0.42; P = .001). In the final model, HbA1C and low-density lipoprotein also remained independently associated with arteriolar caliber. There was no association of adiponectin with venular caliber and retinal vessel calibers in participants <60 years old.Adiponectin is inversely associated with retinal arteriolar caliber in elderly hypertensive participants, suggesting that plasma adiponectin may be a marker of microvascular damage and of higher cardiovascular risk in this age stratum.
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Journal of the American College of Cardiology, 2008
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EFEITO CARDIOPROTETOR DO ÓLEO DE COPAÍBA LIVRE E NANOENCAPSULADO EM UM MODELO DE HIPERTENSÃO ARTE... more EFEITO CARDIOPROTETOR DO ÓLEO DE COPAÍBA LIVRE E NANOENCAPSULADO EM UM MODELO DE HIPERTENSÃO ARTERIAL PULMONAR Cristina Campos, Alexandre Luz de Castro, Angela Maria Vicente Tavares, Rafael Oliveira Fernandes, Vanessa Duarte Ortiz; Cláudio Pereira, Miriam Apel; Susana Llesuy; Alex Sander da Rosa Araujo, Adriane Belló-Klein. Universidade Federal Do Rio Grande Do Sul, Porto Alegre RS Brasil, Centro Universitário UniRitter, Porto Alegre RS Brasil, Tecnano, Porto Alegre RS Brasil, Universidad de Buenos Aires – Argentina. cristinacamposcarraro@gmail.com
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Papers by Angela Maria Vicente Tavares