Papers by Candela Gonzalez
Scientific Reports
Acquired immunodeficiency syndrome (AIDS) is still one of the main health problems worldwide. It ... more Acquired immunodeficiency syndrome (AIDS) is still one of the main health problems worldwide. It is therefore essential to keep making progress in improving the prognosis and quality of life of affected patients. One way to advance along this pathway is to uncover connections between other disorders associated with HIV/AIDS—so that they can be anticipated and possibly mitigated. We propose to achieve this by using Association Rules (ARs). They allow us to represent the dependencies between a number of diseases and other specific diseases. However, classical techniques systematically generate every AR meeting some minimal conditions on data frequency, hence generating a vast amount of uninteresting ARs, which need to be filtered out. The lack of manually annotated ARs has favored unsupervised filtering, even though they produce limited results. In this paper, we propose a semi-supervised system, able to identify relevant ARs among HIV-related diseases with a minimal amount of annotat...
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Mathews Journal of Gynecology & Obstetrics
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Esta obra constituye un significativo referente en el ámbito de las empresas en crisis, porque se... more Esta obra constituye un significativo referente en el ámbito de las empresas en crisis, porque se aborda la consideración de la función jurisdiccional respecto de la insolvencia, teniendo como marco normativo la última reforma, efectuada por el R.D-Ley 3/2009, y principalmente, por cuanto que dicho análisis ha sido desarrollado, brillantemente, por un selecto grupo de especialistas que protagonizan los escenarios más sobresalientes en los que se presentan aquellos instrumentos que actúan frente a la insolvencia. Así, para afrontar la realidad en la que nos encontramos, ha sido necesario contar con el análisis económico de la situación empresarial (Prósper Lamothe, Pilar Gómez, Antonio Portal, Francisco Prada) que da respuesta a las causas que originan la insolvencia. Por su parte, la intervención de profesionales directamente implicados en procesos concursales, tanto desde la perspectiva jurisdiccional (Pablo González-Carreró), como desde la perspectiva de los acreedores que defiend...
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Physiological reports, 2017
Females of the South American plains vizcacha, , show peculiar reproductive features such as mass... more Females of the South American plains vizcacha, , show peculiar reproductive features such as massive polyovulation up to 800 oocytes per estrous cycle and an ovulatory process around mid-gestation arising from the reactivation of the hypothalamic-hypophyseal-ovary (H.H.O.) axis. Estradiol (E) regulates gonadotropin-releasing hormone (GnRH) expression. Biosynthesis of estrogens results from the aromatization of androgens by aromatase, which mainly occurs in the gonads, but has also been described in the hypothalamus. The recently described correlation between GnRH and ER expression patterns in the hypothalamus of the vizcacha during pregnancy, with coexpression in the same neurons of the medial preoptic area, suggests that hypothalamic synthesis of E may affect GnRH neurons and contribute with systemic E to modulate GnRH delivery during the gestation. To elucidate this hypothesis, hypothalamic expression and the action of aromatase on GnRH release were evaluated in female vizcachas t...
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PloS one, 2018
Mammalian testis undergoes deep changes in their architecture and function during photoregression... more Mammalian testis undergoes deep changes in their architecture and function during photoregression conditions in seasonal breeders. Particularly, the testicular mechanisms that regulate the transition between the active (functional) and inactive (regression) stage vary between species. The aim of the present study was to analyze the incidence of proliferation, apoptosis and autophagy in the testicular seminiferous ephitelium of a seasonal breeder, Lagostomus maximus, during the annual reproductive cycle. We observed that proliferating spermatogonia increased from the active testis until reaching the maximum peak in the activating testis. During the annual reproductive cycle, the quantity of apoptotic-TUNEL positive spermatogonia and meiotic germ cells was constant and this might be regulated by the members of the BCL2 family. Only in the activating testis, apoptosis of germ cells was almost undetectable. The analysis of the autophagic-related proteins BECN1 and LC3 showed their local...
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Reproductive biomedicine online, Sep 1, 2018
Recent evidence suggests that cocaine administration in animal models can trigger non-genetic inh... more Recent evidence suggests that cocaine administration in animal models can trigger non-genetic inheritance of addiction traits from father to offspring, affecting development and behaviour. Is chronic cocaine intake involved in alterations of epigenetic homeostasis in the testis? Epigenetic marks and mediators in testis and isolated germ cells of adult mice treated with cocaine (10 mg/kg) or vehicle (sterile saline solution) were evaluated in an intermittent binge protocol: three intraperitoneal injections, 1 h apart, one day on/off for 13 days, collecting tissue 24 h after the last binge administration (day 14). It was shown that chronic cocaine intake in mice disrupts testicular epigenetic homeostasis, increasing global methylated cytosine levels in DNA from germ cells and sperm. Cocaine also increased testicular and germ cell acetylated histone 3 and 4 and decreased expression of histone deacetylases HDAC1/2. Immunolocalization studies showed that HDAC1/2 and acetylated histone 3 ...
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SPAL. Revista de Prehistoria y Arqueología de la Universidad de Sevilla, 2017
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Journal of Molecular Histology, 2017
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PLOS ONE, 2015
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Reproductive Biology, 2015
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Advances in Bioscience and Biotechnology, 2015
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Reproductive Biology and Endocrinology, 2010
Background In non-obstructive azoospermia, histological patterns of Sertoli cell-only Syndrome (S... more Background In non-obstructive azoospermia, histological patterns of Sertoli cell-only Syndrome (SCO) and hypospermatogenesis (H) are commonly found. In these pathologies, Leydig cell hyperplasia (LCH) is detected in some patients. Since TGF-β1 is involved in cellular proliferation/development, the aim of this work was to analyze the expression of TGF-β1, its receptors TGFBRII, TGFBRI (ALK-1 and ALK-5), and the co-receptor endoglin in human biopsies from patients with idiopathic infertility. Methods Specific immunostaining of TGF-β1, its receptors TGFBRII, TGFBRI (ALK-1 and ALK-5), co-receptor endoglin and Smads proteins, were carried out in testicular biopsies from normal and infertile men with SCO or H. Gene expression of TGF-β1 system were made in biopsies from infertile patients with semi-quantitative and quantitative PCR. Results Immunohistochemical studies revealed that TGF-β1 and its specific receptors are present in Leydig cells in biopsies from normal tissue or patients with...
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Reproductive Biology, 2012
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Pediatric Research, 2006
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Journal of Reproduction and Development, 2010
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Journal of Reproduction and Development, 2010
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Fertility and Sterility, 2010
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Journal of Antimicrobial Chemotherapy
Objectives To assess the effectiveness and tolerability of dolutegravir (DTG)/lamivudine (3TC) am... more Objectives To assess the effectiveness and tolerability of dolutegravir (DTG)/lamivudine (3TC) among treatment-naive and virologically suppressed treatment-experienced individuals in the multicentre cohort of the Spanish HIV/AIDS Research Network (CoRIS) during the years 2018–2021. Methods We used multivariable regression models to compare viral suppression (VS) [HIV RNA viral load (VL) <50 copies/mL] and the change in CD4 cell counts at 24 and 48 (±12) weeks after initiation with dolutegravir/lamivudine or other first-line ART regimens. Results We included 2160 treatment-naive subjects, among whom 401 (18.6%) started with dolutegravir/lamivudine. The remaining subjects started bictegravir (BIC)/emtricitabine (FTC)/tenofovir alafenamide (TAF) (n = 949, 43.9%), DTG + FTC/tenofovir disoproxil fumarate (TDF) (n = 282, 13.1%), DTG/3TC/abacavir (ABC) (n = 255, 11.8%), darunavir (DRV)/cobicistat(COBI)/FTC/TAF (n = 147, 6.8%) and elvitegravir (EVG)/COBI/FTC/TAF (n = 126, 5.8%). At 24 an...
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Papers by Candela Gonzalez