The response to antiangiogenic anticancer drugs that inhibit endothelial cell proliferation · 1. Introduction · 2. A simple unstability condition · 3. Application ...
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... cell quiescence and survival (this is also the case for normal tissue), therefore rendering tumour endothelial cells less responsive to anti-angiogenic agents.
In the second part, we use this property to demonstrate that antiangiogenic drugs that act only inhibiting the endothelial cell proliferation might be ...
Feb 5, 2021 · However, as described above, individual patients have a complicated and unreliable response to antiangiogenic drugs and combination treatments.
May 11, 2023 · The most widely used anti-angiogenic agents include monoclonal antibodies and tyrosine kinase inhibitors (TKIs) targeting vascular endothelial ...
Apr 2, 2018 · The goal of these drugs, also called antiangiogenic agents, is to prevent or slow the growth of cancer by starving it of its needed blood supply ...
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Sep 11, 2020 · Collectively, combinatory treatment with anti-angiogenic agents and ICIs is a potential therapeutic option in anti-PD-1-resistant cancer.
To demonstrate that antiangiogenic therapy is refractory to the development of drug resistance, endostatin treatment of tumor-bearing mice was cycled, mimicking ...
Variable ratios of drug concentrations and mutually exclusive equations were used to determine the CIs. This analysis allows drugs with different mechanisms of ...
The dense tumor stroma can limit the access of therapeutic agents to their target due to fibrosis, high interstitial pressure and degradation of drugs by ...