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In this study, we implemented a biophysically detailed computational model of the heart to quantify the effects of the cisapride on cardiac electrical ...
Abstract—Cisapride as a prokinetic drug inhibits rapid delayed rectifier potassium channel current. As producing QT interval prolongation and causes fatal ...
In this study, we implemented a biophysically detailed computational model of the heart to quantify the effects of the cisapride on cardiac electrical ...
Proarrhythmic effects of cisapride: Insights from a simulation study. Y. Yuan, S. Xie, K. Wang, and H. Zhang. BIBM, page 44-47. IEEE Computer Society, (2014 ) ...
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Sep 11, 2014 · These observations suggested that T2 is a useful surrogate for drug-induced prolongations of repolarization and proarrhythmic effects. To test ...
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We also conducted some simulations to demonstrate the application of the virtual heart to assess the pro‐arrhythmic effects of cisapride and amiodarone. Using ...
Nov 1, 2012 · Amiodarone and cisapride are both known to prolong the QT interval, yet the two drugs have different effects on arrhythmia. Cisapride can cause ...
We propose a cardiac safety assay for the detection of proarrhythmic effects of plant extracts based on the experimental approaches described in the ...
Jun 19, 2023 · In this study, we aimed to quantify changes in the morphology of the repolarization phase of the cardiac action potential as an indicator of proarrhythmia.
Oct 2, 2024 · The gold standard for assessing the proarrhythmic risk of a drug traditionally involves measuring its effects on the hERG channel in vitro, a ...