This optimization technique produces the Pareto frontier in the two-objective design space, without explicitly considering the dominated designs. As illustrated ...

This represents the first general-purpose method to directly design combinatorial libraries for multiple objectives characterizing their constituent members.

POCoM (Pareto Optimal Combinatorial Mutagenesis) is instantiate with scores based on a target's protein structure and its homologs' sequences, enabling the ...

This represents the first general-purpose method to directly design combinatorial libraries for multiple objectives characterizing their constituent members.

In order to improve the hit-rate of beneficial variants in such mutagenesis libraries, we develop methods to select optimal posi- tions and corresponding sets ...

The general ability of OCoM (Optimization of Combinatorial Mutagenesis) is demonstrated in enabling the protein engineer to explore and evaluate trade-offs ...

In order to improve the hit-rate of beneficial variants in such mutagenesis libraries, we develop methods to select optimal positions and corresponding sets of ...

Pareto Optimization of Combinatorial Mutagenesis Libraries. D. Verma, G. Grigoryan, and C. Bailey-Kellogg. IEEE/ACM Trans. Comput. Biology Bioinform., 16 (4): ...

Pareto Optimization of Combinatorial Mutagenesis Libraries. Resource URI: https://dblp.l3s.de/d2r/resource/publications/journals/tcbb/VermaGB19. Home ...

Jul 29, 2024 · The effective design of combinatorial libraries to balance fitness and diversity facilitates the engineering of useful enzyme functions, ...