The aim of this study was to investigate the effects of amiodarone on cardiac excitation of the KCNJ2-linked short QT syndrome. Effects of Kir2.1 D172N mutation ...
Jun 7, 2017 · A clinical study by Lu et al. [18] showed that amiodarone prevented the incidence of arrhythmia and prolonged the QT interval in an SQTS patient ...
Nov 18, 2017 · Accordingly, this study aimed to assess the potential effects of CQ on ventricular electrical excitation associated with SQT3, using ...
Effects of amiodarone on ventricular excitation associated with the KCNJ2-linked short QT syndrome: Insights from a modelling study. Modeling and simulation ...
Jun 1, 2017 · Conclusions At the therapeutic-relevant concentration of amiodarone, the APD and ERP at the single cell level were increased significantly. The ...
Jun 13, 2017 · This study provides mechanistic insights into atrial proarrhythmia with SQT3 Kir2.1 mutations and highlights possible pharmacological strategies for management ...
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Here we report a different KCNJ2 mutation (E299V) identified in a child with a remarkably short QT interval and atrial fibrillation (AF). In vitro expression ...
They found that shortening of the action potential in SQTS is associated with reduced ventricular mechanical function. Collectively, in silico modeling of the ...
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What effect does amiodarone have on QT interval?
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The aim of this study was to investigate the effects of amiodarone on cardiac excitation of the KCNJ2-linked short QT syndrome. Effects of Kir2.1 D172N ...
The SQTS variant 3 is linked to D172N mutation to the KCNJ2 gene that causes a gain-of-function to the inward rectifier potassium channel current (I K1), which ...