Jul 1, 2012 · We propose a new conditioning approach, which is based in part on the classical technique of liability threshold modeling.
Cases are assigned positive-valued phenotypes and controls negative-valued phenotypes. Individuals carrying a smaller number of risk alleles are given a larger ...
Here, we propose a new conditioning approach, which is based in part on the classical technique of liability threshold modeling. Roughly, this method estimates ...
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What is case-control association studies?
What type of statistical test is used for case-control association?
What is GWAS or common variants?
Which type of variant is studied in genome-wide association studies?
In this review, we provide an overview of statistical issues in rare-variant association studies with a focus on study designs and statistical tests.
Dive into the research topics of 'Analysis of case-control association studies with known risk variants'. Together they form a unique fingerprint. Sort by ...
Aug 26, 2021 · Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants across many genomes to find those statistically associated with a ...
Case-control studies are the most frequently performed type of genetic association studies because they are simpler to implement than family-based designs.
This study provides new insights into the genetic susceptibility of pancreatic cancer, refining rare variant risk estimates in known pancreatic cancer ...
Jan 22, 2019 · Our results provide important insights into rare variant association study designs by providing a landscape of type I error and statistical power for a wide ...
Jul 8, 2010 · The genomewide association study is typically based on a case–control design in which single-nucleotide polymorphisms (SNPs) across the human ...