We present a novel efficient computational approach, named GlycoDeNovo, for accurate elucidation of the glycan topologies from their tandem mass spectra. Given a spectrum, GlycoDeNovo first builds an interpretation-graph specifying how to interpret each peak using preceding interpreted peaks.
A Novel Algorithm for Glycan de novo Sequencing Using Tandem Mass Spectrometry. Conference paper. pp 320–330; Cite this conference paper. Download book PDF.
In this paper, we proposed a heuristic algorithm for glycan de novo sequencing from HCD MS/MS spectra of ... sequencing using tandem mass spectrometry.
One of the most powerful tools for glycan structure determination is tandem mass spectrometry. Interpreting the tandem mass spectra of glycopeptides with de ...
In the past decade, tandem mass spectrometry (MS/MS) has gradually served as an effective technique in glycoproteomics analysis because of its high throughput ...
A Machine Learning Based Approach to de novo Sequencing of Glycans ...
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May 6, 2015 · We present a machine learning based approach to de novo sequencing of glycans from MS/MS spectrum. First, we build a suitable model for the ...
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Feb 14, 2022 · Previously, we developed GlycoDeNovo, a de novo algorithm for reconstructing glycan topologies from tandem mass spectra (MS/MS). In this work, ...
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What is de novo sequencing using tandem mass spectrometry?
Interpreting the tandem mass spectra of glycopeptides with a de novo sequencing method is essential to identifying novel glycan structures. Thus, we ...
Jul 1, 2024 · We demonstrate that this can be used for de novo annotation, diagnostic fragment identification and high-throughput glycomics. For maximum ...
We show in this paper that glycan de novo sequencing is NP-hard. We then provide a heuristic algorithm and develop a software program to solve the problem in ...