It has been theoretically shown that dynamic relationship between activation and suppression of local translation at glumatergic synapses in response to their activation may result in formation of complex dynamics of postsynaptic protein synthesis in the area of physiological functioning of this system, and, therefore, ...
Sep 14, 2020
Sep 14, 2020 · The present study is devoted to a theoretical analysis of the local translation system dynamic properties and identification of parameters affecting the ...
Dec 5, 2017 · Nowadays, the dynamic aspects of local translation at the activated synapse are poorly understood. It is possible that, in some cases, ...
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Jul 14, 2021 · Recent studies have pointed to a coordination of the local mRNA translation required for synaptic plasticity and the trafficking of membranous organelles in ...
In this review, we focus on the various aspects of these local translation compartments such as size, biochemical and organelle composition, structural ...
The exact localization pattern of Arc mRNA depends on the synapses that were activated. Newly synthesized Arc protein also accumulates in the activated ...
Here, we describe a mechanism how dendritic mRNAs are transported and subsequently translated at activated synapses.
Sep 8, 2023 · Because local translation is required for synaptic plasticity, and synaptic plasticity is the cellular analogue for memory, local translation ...
Abstract: Background: The key role in the dynamic regulation of synaptic protein turnover belongs to the Fragile X Mental Retardation Protein, ...
Jan 13, 2024 · So, enhanced activity of the local translation system can be a factor of its instability and that of the risk of neuro-psychical diseases ...