Enhancers produce non-coding transcripts
In addition to TFs, RNA polymerase II (RNAPII) has also been found to be localized at many enhancers. In mouse cortical neurons, a large number of neuronal activity-controlled enhancers are recognized by the general transcriptional co-activator CREB binding protein (CBP).
Jun 6, 2017
Jun 17, 2017 · Furthermore, recent studies have demonstrated that many enhancer elements can be transcribed and produce RNA molecules, which are termed as ...
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Dec 22, 2020 · Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs) are widely expressed and have key roles in gene regulation.
Recent studies have shown that enhancers can act as transcriptional units for the production of enhancer RNAs (eRNAs), which are hallmarks of activity ...
May 17, 2023 · In this mini-review, we summarize the well-established regulatory models for eRNA actions and highlight the recent insights into the structure and chemical ...
Aug 30, 2022 · In this Primer, we survey the diverse roles played by eRNAs in enhancer-dependent gene expression, evaluating different models for eRNA function.
Jan 3, 2023 · Many lncRNAs associate with chromatin-modifying complexes, are transcribed from enhancers and nucleate phase separation of nuclear condensates ...
Oct 22, 2024 · Long non-coding RNAs (lncRNAs) are a class of non-protein-coding transcripts that have emerged as pivotal regulators of various cellular ...
Jun 6, 2019 · In this review, we bring together data from recent studies indicating that non-coding RNA transcription from active enhancers, as well as ...
We focus on the long non-coding steroid receptor RNA activator (SRA), including new insights into its effects on gene expression, the cell cycle, and ...