Aug 30, 2021 · Here, we estimate the fitness effect of missense mutations with different interactome perturbation patterns in human.
Aug 30, 2021 · By disrupting overall protein stability, quasi-null mutations cause complex cellular and phenotypic changes that are not explainable by simple ...
Missense mutations are known to perturb protein-protein interaction networks (known as interactome networks) in different ways.
People also ask
How does mutation affect fitness?
What types of effects can mutations have on the fitness of an organism?
Our results suggest that while mutations that do not disrupt the interactome tend to be effectively neutral, the majority of human PPIs are under strong ...
... fitness effect for different mutation edgotypes. Other computational methods are able to predict the effect of individual mutations on protein folding and ...
Mutation edgotype drives fitness effect in human. M Ghadie, Y Xia. Frontiers in Bioinformatics 1, 690769, 2021. 3, 2021. Gene selection for the reconstruction ...
However, it remains unknown how different interactome perturbation patterns (“edgotypes”) impact organismal fitness. Here, we estimate the fitness effect of ...
Jul 19, 2019 · Our estimate of dispensable content in the human reference interactome is robust to the presence of gain-of-function mutations. Gain-of-function ...
FIGURE 5 | Procedure for the calculation of edgotype fitness effect.... Mutation Edgotype Drives Fitness Effect in Human.
Aug 9, 2023 · ... effects by mutations, edgotype-based analysis of population. 10 phenotypic variance, and network analysis of detrimental mutations. 11. 12. 13.
Missing: Fitness | Show results with:Fitness