data_6ZDG # _entry.id 6ZDG # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.399 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code _database_2.pdbx_database_accession _database_2.pdbx_DOI PDB 6ZDG pdb_00006zdg 10.2210/pdb6zdg/pdb WWPDB D_1292109375 ? ? EMDB EMD-11173 ? ? # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2020-07-29 2 'Structure model' 1 1 2020-08-12 3 'Structure model' 1 2 2020-10-21 4 'Structure model' 1 3 2021-02-10 5 'Structure model' 1 4 2021-12-22 6 'Structure model' 1 5 2024-11-20 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? _pdbx_audit_revision_details.details ? # loop_ _pdbx_audit_revision_group.ordinal _pdbx_audit_revision_group.revision_ordinal _pdbx_audit_revision_group.data_content_type _pdbx_audit_revision_group.group 1 2 'Structure model' 'Database references' 2 3 'Structure model' 'Database references' 3 4 'Structure model' 'Database references' 4 5 'Structure model' 'Database references' 5 5 'Structure model' 'Source and taxonomy' 6 5 'Structure model' 'Structure summary' 7 6 'Structure model' 'Data collection' 8 6 'Structure model' 'Structure summary' # loop_ _pdbx_audit_revision_category.ordinal _pdbx_audit_revision_category.revision_ordinal _pdbx_audit_revision_category.data_content_type _pdbx_audit_revision_category.category 1 2 'Structure model' citation 2 2 'Structure model' citation_author 3 3 'Structure model' citation 4 3 'Structure model' citation_author 5 4 'Structure model' citation_author 6 5 'Structure model' database_2 7 5 'Structure model' entity 8 5 'Structure model' entity_name_com 9 5 'Structure model' entity_src_gen 10 6 'Structure model' chem_comp_atom 11 6 'Structure model' chem_comp_bond 12 6 'Structure model' em_admin 13 6 'Structure model' pdbx_entry_details 14 6 'Structure model' pdbx_modification_feature # loop_ _pdbx_audit_revision_item.ordinal _pdbx_audit_revision_item.revision_ordinal _pdbx_audit_revision_item.data_content_type _pdbx_audit_revision_item.item 1 2 'Structure model' '_citation.country' 2 2 'Structure model' '_citation.journal_abbrev' 3 2 'Structure model' '_citation.journal_id_CSD' 4 2 'Structure model' '_citation.journal_id_ISSN' 5 2 'Structure model' '_citation.pdbx_database_id_DOI' 6 2 'Structure model' '_citation.pdbx_database_id_PubMed' 7 2 'Structure model' '_citation.title' 8 2 'Structure model' '_citation.year' 9 3 'Structure model' '_citation.journal_volume' 10 3 'Structure model' '_citation.page_first' 11 3 'Structure model' '_citation.page_last' 12 3 'Structure model' '_citation_author.identifier_ORCID' 13 4 'Structure model' '_citation_author.identifier_ORCID' 14 5 'Structure model' '_database_2.pdbx_DOI' 15 5 'Structure model' '_database_2.pdbx_database_accession' 16 5 'Structure model' '_entity.pdbx_description' 17 5 'Structure model' '_entity_src_gen.gene_src_common_name' 18 6 'Structure model' '_em_admin.last_update' 19 6 'Structure model' '_pdbx_entry_details.has_protein_modification' # _pdbx_database_status.status_code REL _pdbx_database_status.status_code_sf ? _pdbx_database_status.status_code_mr ? _pdbx_database_status.entry_id 6ZDG _pdbx_database_status.recvd_initial_deposition_date 2020-06-14 _pdbx_database_status.SG_entry N _pdbx_database_status.deposit_site PDBE _pdbx_database_status.process_site PDBE _pdbx_database_status.status_code_cs ? _pdbx_database_status.status_code_nmr_data ? _pdbx_database_status.methods_development_category ? _pdbx_database_status.pdb_format_compatible Y # loop_ _pdbx_database_related.db_name _pdbx_database_related.details _pdbx_database_related.db_id _pdbx_database_related.content_type PDB . 6ZCZ unspecified EMDB 'Association of three complexes of largely structurally disordered Spike ectodomain with bound EY6A Fab' EMD-11173 'associated EM volume' # loop_ _audit_author.name _audit_author.pdbx_ordinal _audit_author.identifier_ORCID 'Duyvesteyn, H.M.E.' 1 ? 'Zhou, D.' 2 ? 'Zhao, Y.' 3 ? 'Fry, E.E.' 4 ? 'Ren, J.' 5 ? 'Stuart, D.I.' 6 ? # _citation.abstract ? _citation.abstract_id_CAS ? _citation.book_id_ISBN ? _citation.book_publisher ? _citation.book_publisher_city ? _citation.book_title ? _citation.coordinate_linkage ? _citation.country US _citation.database_id_Medline ? _citation.details ? _citation.id primary _citation.journal_abbrev Nat.Struct.Mol.Biol. _citation.journal_id_ASTM ? _citation.journal_id_CSD ? _citation.journal_id_ISSN 1545-9985 _citation.journal_full ? _citation.journal_issue ? _citation.journal_volume 27 _citation.language ? _citation.page_first 950 _citation.page_last 958 _citation.title 'Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient.' _citation.year 2020 _citation.database_id_CSD ? _citation.pdbx_database_id_DOI 10.1038/s41594-020-0480-y _citation.pdbx_database_id_PubMed 32737466 _citation.unpublished_flag ? # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal _citation_author.identifier_ORCID primary 'Zhou, D.' 1 ? primary 'Duyvesteyn, H.M.E.' 2 ? primary 'Chen, C.P.' 3 ? primary 'Huang, C.G.' 4 ? primary 'Chen, T.H.' 5 ? primary 'Shih, S.R.' 6 ? primary 'Lin, Y.C.' 7 ? primary 'Cheng, C.Y.' 8 ? primary 'Cheng, S.H.' 9 ? primary 'Huang, Y.C.' 10 ? primary 'Lin, T.Y.' 11 ? primary 'Ma, C.' 12 0000-0002-4741-2307 primary 'Huo, J.' 13 ? primary 'Carrique, L.' 14 ? primary 'Malinauskas, T.' 15 0000-0002-4847-5529 primary 'Ruza, R.R.' 16 ? primary 'Shah, P.N.M.' 17 ? primary 'Tan, T.K.' 18 0000-0001-8746-8308 primary 'Rijal, P.' 19 ? primary 'Donat, R.F.' 20 ? primary 'Godwin, K.' 21 ? primary 'Buttigieg, K.R.' 22 ? primary 'Tree, J.A.' 23 ? primary 'Radecke, J.' 24 ? primary 'Paterson, N.G.' 25 0000-0003-4292-6971 primary 'Supasa, P.' 26 ? primary 'Mongkolsapaya, J.' 27 ? primary 'Screaton, G.R.' 28 0000-0002-3549-4309 primary 'Carroll, M.W.' 29 ? primary 'Gilbert-Jaramillo, J.' 30 0000-0003-1268-2304 primary 'Knight, M.L.' 31 0000-0002-8780-1630 primary 'James, W.' 32 0000-0002-2506-1198 primary 'Owens, R.J.' 33 0000-0002-3705-2993 primary 'Naismith, J.H.' 34 0000-0001-6744-5061 primary 'Townsend, A.R.' 35 ? primary 'Fry, E.E.' 36 0000-0001-9754-5303 primary 'Zhao, Y.' 37 0000-0001-8916-8552 primary 'Ren, J.' 38 0000-0003-4015-1404 primary 'Stuart, D.I.' 39 0000-0002-3426-4210 primary 'Huang, K.A.' 40 0000-0001-6891-6945 # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer man 'Spike protein S1' 21776.381 3 ? ? ? ? 2 polymer man 'EY6A heavy chain' 24346.273 3 ? ? ? ? 3 polymer man 'EY6A light chain' 23315.855 3 ? ? ? ? 4 non-polymer man 2-acetamido-2-deoxy-beta-D-glucopyranose 221.208 3 ? ? ? ? # loop_ _entity_poly.entity_id _entity_poly.type _entity_poly.nstd_linkage _entity_poly.nstd_monomer _entity_poly.pdbx_seq_one_letter_code _entity_poly.pdbx_seq_one_letter_code_can _entity_poly.pdbx_strand_id _entity_poly.pdbx_target_identifier 1 'polypeptide(L)' no no ;TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAP GQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPL QSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCG ; ;TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAP GQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPL QSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCG ; E,A,D ? 2 'polypeptide(L)' no no ;EVQLVESGGGVVQPGRSLRLSCAASAFTFSSYDMHWVRQAPGKGLEWVAVISYDGSNKYYADSVKGRFTISRDNSKNTLY LQMNSLRAEDTAVYYCAKDGGKLWVYYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK ; ;EVQLVESGGGVVQPGRSLRLSCAASAFTFSSYDMHWVRQAPGKGLEWVAVISYDGSNKYYADSVKGRFTISRDNSKNTLY LQMNSLRAEDTAVYYCAKDGGKLWVYYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK ; H,B,F ? 3 'polypeptide(L)' no no ;DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQP EDFATYYCQQSYSTLALTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNS QESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC ; ;DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQP EDFATYYCQQSYSTLALTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNS QESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC ; L,C,G ? # _pdbx_entity_nonpoly.entity_id 4 _pdbx_entity_nonpoly.name 2-acetamido-2-deoxy-beta-D-glucopyranose _pdbx_entity_nonpoly.comp_id NAG # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 THR n 1 2 ASN n 1 3 LEU n 1 4 CYS n 1 5 PRO n 1 6 PHE n 1 7 GLY n 1 8 GLU n 1 9 VAL n 1 10 PHE n 1 11 ASN n 1 12 ALA n 1 13 THR n 1 14 ARG n 1 15 PHE n 1 16 ALA n 1 17 SER n 1 18 VAL n 1 19 TYR n 1 20 ALA n 1 21 TRP n 1 22 ASN n 1 23 ARG n 1 24 LYS n 1 25 ARG n 1 26 ILE n 1 27 SER n 1 28 ASN n 1 29 CYS n 1 30 VAL n 1 31 ALA n 1 32 ASP n 1 33 TYR n 1 34 SER n 1 35 VAL n 1 36 LEU n 1 37 TYR n 1 38 ASN n 1 39 SER n 1 40 ALA n 1 41 SER n 1 42 PHE n 1 43 SER n 1 44 THR n 1 45 PHE n 1 46 LYS n 1 47 CYS n 1 48 TYR n 1 49 GLY n 1 50 VAL n 1 51 SER n 1 52 PRO n 1 53 THR n 1 54 LYS n 1 55 LEU n 1 56 ASN n 1 57 ASP n 1 58 LEU n 1 59 CYS n 1 60 PHE n 1 61 THR n 1 62 ASN n 1 63 VAL n 1 64 TYR n 1 65 ALA n 1 66 ASP n 1 67 SER n 1 68 PHE n 1 69 VAL n 1 70 ILE n 1 71 ARG n 1 72 GLY n 1 73 ASP n 1 74 GLU n 1 75 VAL n 1 76 ARG n 1 77 GLN n 1 78 ILE n 1 79 ALA n 1 80 PRO n 1 81 GLY n 1 82 GLN n 1 83 THR n 1 84 GLY n 1 85 LYS n 1 86 ILE n 1 87 ALA n 1 88 ASP n 1 89 TYR n 1 90 ASN n 1 91 TYR n 1 92 LYS n 1 93 LEU n 1 94 PRO n 1 95 ASP n 1 96 ASP n 1 97 PHE n 1 98 THR n 1 99 GLY n 1 100 CYS n 1 101 VAL n 1 102 ILE n 1 103 ALA n 1 104 TRP n 1 105 ASN n 1 106 SER n 1 107 ASN n 1 108 ASN n 1 109 LEU n 1 110 ASP n 1 111 SER n 1 112 LYS n 1 113 VAL n 1 114 GLY n 1 115 GLY n 1 116 ASN n 1 117 TYR n 1 118 ASN n 1 119 TYR n 1 120 LEU n 1 121 TYR n 1 122 ARG n 1 123 LEU n 1 124 PHE n 1 125 ARG n 1 126 LYS n 1 127 SER n 1 128 ASN n 1 129 LEU n 1 130 LYS n 1 131 PRO n 1 132 PHE n 1 133 GLU n 1 134 ARG n 1 135 ASP n 1 136 ILE n 1 137 SER n 1 138 THR n 1 139 GLU n 1 140 ILE n 1 141 TYR n 1 142 GLN n 1 143 ALA n 1 144 GLY n 1 145 SER n 1 146 THR n 1 147 PRO n 1 148 CYS n 1 149 ASN n 1 150 GLY n 1 151 VAL n 1 152 GLU n 1 153 GLY n 1 154 PHE n 1 155 ASN n 1 156 CYS n 1 157 TYR n 1 158 PHE n 1 159 PRO n 1 160 LEU n 1 161 GLN n 1 162 SER n 1 163 TYR n 1 164 GLY n 1 165 PHE n 1 166 GLN n 1 167 PRO n 1 168 THR n 1 169 ASN n 1 170 GLY n 1 171 VAL n 1 172 GLY n 1 173 TYR n 1 174 GLN n 1 175 PRO n 1 176 TYR n 1 177 ARG n 1 178 VAL n 1 179 VAL n 1 180 VAL n 1 181 LEU n 1 182 SER n 1 183 PHE n 1 184 GLU n 1 185 LEU n 1 186 LEU n 1 187 HIS n 1 188 ALA n 1 189 PRO n 1 190 ALA n 1 191 THR n 1 192 VAL n 1 193 CYS n 1 194 GLY n 2 1 GLU n 2 2 VAL n 2 3 GLN n 2 4 LEU n 2 5 VAL n 2 6 GLU n 2 7 SER n 2 8 GLY n 2 9 GLY n 2 10 GLY n 2 11 VAL n 2 12 VAL n 2 13 GLN n 2 14 PRO n 2 15 GLY n 2 16 ARG n 2 17 SER n 2 18 LEU n 2 19 ARG n 2 20 LEU n 2 21 SER n 2 22 CYS n 2 23 ALA n 2 24 ALA n 2 25 SER n 2 26 ALA n 2 27 PHE n 2 28 THR n 2 29 PHE n 2 30 SER n 2 31 SER n 2 32 TYR n 2 33 ASP n 2 34 MET n 2 35 HIS n 2 36 TRP n 2 37 VAL n 2 38 ARG n 2 39 GLN n 2 40 ALA n 2 41 PRO n 2 42 GLY n 2 43 LYS n 2 44 GLY n 2 45 LEU n 2 46 GLU n 2 47 TRP n 2 48 VAL n 2 49 ALA n 2 50 VAL n 2 51 ILE n 2 52 SER n 2 53 TYR n 2 54 ASP n 2 55 GLY n 2 56 SER n 2 57 ASN n 2 58 LYS n 2 59 TYR n 2 60 TYR n 2 61 ALA n 2 62 ASP n 2 63 SER n 2 64 VAL n 2 65 LYS n 2 66 GLY n 2 67 ARG n 2 68 PHE n 2 69 THR n 2 70 ILE n 2 71 SER n 2 72 ARG n 2 73 ASP n 2 74 ASN n 2 75 SER n 2 76 LYS n 2 77 ASN n 2 78 THR n 2 79 LEU n 2 80 TYR n 2 81 LEU n 2 82 GLN n 2 83 MET n 2 84 ASN n 2 85 SER n 2 86 LEU n 2 87 ARG n 2 88 ALA n 2 89 GLU n 2 90 ASP n 2 91 THR n 2 92 ALA n 2 93 VAL n 2 94 TYR n 2 95 TYR n 2 96 CYS n 2 97 ALA n 2 98 LYS n 2 99 ASP n 2 100 GLY n 2 101 GLY n 2 102 LYS n 2 103 LEU n 2 104 TRP n 2 105 VAL n 2 106 TYR n 2 107 TYR n 2 108 PHE n 2 109 ASP n 2 110 TYR n 2 111 TRP n 2 112 GLY n 2 113 GLN n 2 114 GLY n 2 115 THR n 2 116 LEU n 2 117 VAL n 2 118 THR n 2 119 VAL n 2 120 SER n 2 121 SER n 2 122 ALA n 2 123 SER n 2 124 THR n 2 125 LYS n 2 126 GLY n 2 127 PRO n 2 128 SER n 2 129 VAL n 2 130 PHE n 2 131 PRO n 2 132 LEU n 2 133 ALA n 2 134 PRO n 2 135 SER n 2 136 SER n 2 137 LYS n 2 138 SER n 2 139 THR n 2 140 SER n 2 141 GLY n 2 142 GLY n 2 143 THR n 2 144 ALA n 2 145 ALA n 2 146 LEU n 2 147 GLY n 2 148 CYS n 2 149 LEU n 2 150 VAL n 2 151 LYS n 2 152 ASP n 2 153 TYR n 2 154 PHE n 2 155 PRO n 2 156 GLU n 2 157 PRO n 2 158 VAL n 2 159 THR n 2 160 VAL n 2 161 SER n 2 162 TRP n 2 163 ASN n 2 164 SER n 2 165 GLY n 2 166 ALA n 2 167 LEU n 2 168 THR n 2 169 SER n 2 170 GLY n 2 171 VAL n 2 172 HIS n 2 173 THR n 2 174 PHE n 2 175 PRO n 2 176 ALA n 2 177 VAL n 2 178 LEU n 2 179 GLN n 2 180 SER n 2 181 SER n 2 182 GLY n 2 183 LEU n 2 184 TYR n 2 185 SER n 2 186 LEU n 2 187 SER n 2 188 SER n 2 189 VAL n 2 190 VAL n 2 191 THR n 2 192 VAL n 2 193 PRO n 2 194 SER n 2 195 SER n 2 196 SER n 2 197 LEU n 2 198 GLY n 2 199 THR n 2 200 GLN n 2 201 THR n 2 202 TYR n 2 203 ILE n 2 204 CYS n 2 205 ASN n 2 206 VAL n 2 207 ASN n 2 208 HIS n 2 209 LYS n 2 210 PRO n 2 211 SER n 2 212 ASN n 2 213 THR n 2 214 LYS n 2 215 VAL n 2 216 ASP n 2 217 LYS n 2 218 ARG n 2 219 VAL n 2 220 GLU n 2 221 PRO n 2 222 LYS n 2 223 SER n 2 224 CYS n 2 225 ASP n 2 226 LYS n 3 1 ASP n 3 2 ILE n 3 3 GLN n 3 4 MET n 3 5 THR n 3 6 GLN n 3 7 SER n 3 8 PRO n 3 9 SER n 3 10 SER n 3 11 LEU n 3 12 SER n 3 13 ALA n 3 14 SER n 3 15 VAL n 3 16 GLY n 3 17 ASP n 3 18 ARG n 3 19 VAL n 3 20 THR n 3 21 ILE n 3 22 THR n 3 23 CYS n 3 24 ARG n 3 25 ALA n 3 26 SER n 3 27 GLN n 3 28 SER n 3 29 ILE n 3 30 SER n 3 31 SER n 3 32 TYR n 3 33 LEU n 3 34 ASN n 3 35 TRP n 3 36 TYR n 3 37 GLN n 3 38 GLN n 3 39 LYS n 3 40 PRO n 3 41 GLY n 3 42 LYS n 3 43 ALA n 3 44 PRO n 3 45 LYS n 3 46 LEU n 3 47 LEU n 3 48 ILE n 3 49 TYR n 3 50 ALA n 3 51 ALA n 3 52 SER n 3 53 SER n 3 54 LEU n 3 55 GLN n 3 56 SER n 3 57 GLY n 3 58 VAL n 3 59 PRO n 3 60 SER n 3 61 ARG n 3 62 PHE n 3 63 SER n 3 64 GLY n 3 65 SER n 3 66 GLY n 3 67 SER n 3 68 GLY n 3 69 THR n 3 70 ASP n 3 71 PHE n 3 72 THR n 3 73 LEU n 3 74 THR n 3 75 ILE n 3 76 SER n 3 77 SER n 3 78 LEU n 3 79 GLN n 3 80 PRO n 3 81 GLU n 3 82 ASP n 3 83 PHE n 3 84 ALA n 3 85 THR n 3 86 TYR n 3 87 TYR n 3 88 CYS n 3 89 GLN n 3 90 GLN n 3 91 SER n 3 92 TYR n 3 93 SER n 3 94 THR n 3 95 LEU n 3 96 ALA n 3 97 LEU n 3 98 THR n 3 99 PHE n 3 100 GLY n 3 101 GLY n 3 102 GLY n 3 103 THR n 3 104 LYS n 3 105 VAL n 3 106 GLU n 3 107 ILE n 3 108 LYS n 3 109 ARG n 3 110 THR n 3 111 VAL n 3 112 ALA n 3 113 ALA n 3 114 PRO n 3 115 SER n 3 116 VAL n 3 117 PHE n 3 118 ILE n 3 119 PHE n 3 120 PRO n 3 121 PRO n 3 122 SER n 3 123 ASP n 3 124 GLU n 3 125 GLN n 3 126 LEU n 3 127 LYS n 3 128 SER n 3 129 GLY n 3 130 THR n 3 131 ALA n 3 132 SER n 3 133 VAL n 3 134 VAL n 3 135 CYS n 3 136 LEU n 3 137 LEU n 3 138 ASN n 3 139 ASN n 3 140 PHE n 3 141 TYR n 3 142 PRO n 3 143 ARG n 3 144 GLU n 3 145 ALA n 3 146 LYS n 3 147 VAL n 3 148 GLN n 3 149 TRP n 3 150 LYS n 3 151 VAL n 3 152 ASP n 3 153 ASN n 3 154 ALA n 3 155 LEU n 3 156 GLN n 3 157 SER n 3 158 GLY n 3 159 ASN n 3 160 SER n 3 161 GLN n 3 162 GLU n 3 163 SER n 3 164 VAL n 3 165 THR n 3 166 GLU n 3 167 GLN n 3 168 ASP n 3 169 SER n 3 170 LYS n 3 171 ASP n 3 172 SER n 3 173 THR n 3 174 TYR n 3 175 SER n 3 176 LEU n 3 177 SER n 3 178 SER n 3 179 THR n 3 180 LEU n 3 181 THR n 3 182 LEU n 3 183 SER n 3 184 LYS n 3 185 ALA n 3 186 ASP n 3 187 TYR n 3 188 GLU n 3 189 LYS n 3 190 HIS n 3 191 LYS n 3 192 VAL n 3 193 TYR n 3 194 ALA n 3 195 CYS n 3 196 GLU n 3 197 VAL n 3 198 THR n 3 199 HIS n 3 200 GLN n 3 201 GLY n 3 202 LEU n 3 203 SER n 3 204 SER n 3 205 PRO n 3 206 VAL n 3 207 THR n 3 208 LYS n 3 209 SER n 3 210 PHE n 3 211 ASN n 3 212 ARG n 3 213 GLY n 3 214 GLU n 3 215 CYS n # loop_ _entity_src_gen.entity_id _entity_src_gen.pdbx_src_id _entity_src_gen.pdbx_alt_source_flag _entity_src_gen.pdbx_seq_type _entity_src_gen.pdbx_beg_seq_num _entity_src_gen.pdbx_end_seq_num _entity_src_gen.gene_src_common_name _entity_src_gen.gene_src_genus _entity_src_gen.pdbx_gene_src_gene _entity_src_gen.gene_src_species _entity_src_gen.gene_src_strain _entity_src_gen.gene_src_tissue _entity_src_gen.gene_src_tissue_fraction _entity_src_gen.gene_src_details _entity_src_gen.pdbx_gene_src_fragment _entity_src_gen.pdbx_gene_src_scientific_name _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id _entity_src_gen.pdbx_gene_src_variant _entity_src_gen.pdbx_gene_src_cell_line _entity_src_gen.pdbx_gene_src_atcc _entity_src_gen.pdbx_gene_src_organ _entity_src_gen.pdbx_gene_src_organelle _entity_src_gen.pdbx_gene_src_cell _entity_src_gen.pdbx_gene_src_cellular_location _entity_src_gen.host_org_common_name _entity_src_gen.pdbx_host_org_scientific_name _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id _entity_src_gen.host_org_genus _entity_src_gen.pdbx_host_org_gene _entity_src_gen.pdbx_host_org_organ _entity_src_gen.host_org_species _entity_src_gen.pdbx_host_org_tissue _entity_src_gen.pdbx_host_org_tissue_fraction _entity_src_gen.pdbx_host_org_strain _entity_src_gen.pdbx_host_org_variant _entity_src_gen.pdbx_host_org_cell_line _entity_src_gen.pdbx_host_org_atcc _entity_src_gen.pdbx_host_org_culture_collection _entity_src_gen.pdbx_host_org_cell _entity_src_gen.pdbx_host_org_organelle _entity_src_gen.pdbx_host_org_cellular_location _entity_src_gen.pdbx_host_org_vector_type _entity_src_gen.pdbx_host_org_vector _entity_src_gen.host_org_details _entity_src_gen.expression_system_id _entity_src_gen.plasmid_name _entity_src_gen.plasmid_details _entity_src_gen.pdbx_description 1 1 sample 'Biological sequence' 1 194 ? ? 'S, 2' ? ? ? ? ? ? 'Severe acute respiratory syndrome coronavirus 2' 2697049 ? ? ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 2 1 sample 'Biological sequence' 1 226 ? ? ? ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'Cricetulus griseus' 10029 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 3 1 sample 'Biological sequence' 1 215 ? ? ? ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'Cricetulus griseus' 10029 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 NAG 'D-saccharide, beta linking' . 2-acetamido-2-deoxy-beta-D-glucopyranose ;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE ; 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 # loop_ _pdbx_chem_comp_identifier.comp_id _pdbx_chem_comp_identifier.type _pdbx_chem_comp_identifier.program _pdbx_chem_comp_identifier.program_version _pdbx_chem_comp_identifier.identifier NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML 1.0 DGlcpNAcb NAG 'COMMON NAME' GMML 1.0 N-acetyl-b-D-glucopyranosamine NAG 'IUPAC CARBOHYDRATE SYMBOL' PDB-CARE 1.0 b-D-GlcpNAc NAG 'SNFG CARBOHYDRATE SYMBOL' GMML 1.0 GlcNAc # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 THR 1 333 333 THR THR E . n A 1 2 ASN 2 334 334 ASN ASN E . n A 1 3 LEU 3 335 335 LEU LEU E . n A 1 4 CYS 4 336 336 CYS CYS E . n A 1 5 PRO 5 337 337 PRO PRO E . n A 1 6 PHE 6 338 338 PHE PHE E . n A 1 7 GLY 7 339 339 GLY GLY E . n A 1 8 GLU 8 340 340 GLU GLU E . n A 1 9 VAL 9 341 341 VAL VAL E . n A 1 10 PHE 10 342 342 PHE PHE E . n A 1 11 ASN 11 343 343 ASN ASN E . n A 1 12 ALA 12 344 344 ALA ALA E . n A 1 13 THR 13 345 345 THR THR E . n A 1 14 ARG 14 346 346 ARG ARG E . n A 1 15 PHE 15 347 347 PHE PHE E . n A 1 16 ALA 16 348 348 ALA ALA E . n A 1 17 SER 17 349 349 SER SER E . n A 1 18 VAL 18 350 350 VAL VAL E . n A 1 19 TYR 19 351 351 TYR TYR E . n A 1 20 ALA 20 352 352 ALA ALA E . n A 1 21 TRP 21 353 353 TRP TRP E . n A 1 22 ASN 22 354 354 ASN ASN E . n A 1 23 ARG 23 355 355 ARG ARG E . n A 1 24 LYS 24 356 356 LYS LYS E . n A 1 25 ARG 25 357 357 ARG ARG E . n A 1 26 ILE 26 358 358 ILE ILE E . n A 1 27 SER 27 359 359 SER SER E . n A 1 28 ASN 28 360 360 ASN ASN E . n A 1 29 CYS 29 361 361 CYS CYS E . n A 1 30 VAL 30 362 362 VAL VAL E . n A 1 31 ALA 31 363 363 ALA ALA E . n A 1 32 ASP 32 364 364 ASP ASP E . n A 1 33 TYR 33 365 365 TYR TYR E . n A 1 34 SER 34 366 366 SER SER E . n A 1 35 VAL 35 367 367 VAL VAL E . n A 1 36 LEU 36 368 368 LEU LEU E . n A 1 37 TYR 37 369 369 TYR TYR E . n A 1 38 ASN 38 370 370 ASN ASN E . n A 1 39 SER 39 371 371 SER SER E . n A 1 40 ALA 40 372 372 ALA ALA E . n A 1 41 SER 41 373 373 SER SER E . n A 1 42 PHE 42 374 374 PHE PHE E . n A 1 43 SER 43 375 375 SER SER E . n A 1 44 THR 44 376 376 THR THR E . n A 1 45 PHE 45 377 377 PHE PHE E . n A 1 46 LYS 46 378 378 LYS LYS E . n A 1 47 CYS 47 379 379 CYS CYS E . n A 1 48 TYR 48 380 380 TYR TYR E . n A 1 49 GLY 49 381 381 GLY GLY E . n A 1 50 VAL 50 382 382 VAL VAL E . n A 1 51 SER 51 383 383 SER SER E . n A 1 52 PRO 52 384 384 PRO PRO E . n A 1 53 THR 53 385 385 THR THR E . n A 1 54 LYS 54 386 386 LYS LYS E . n A 1 55 LEU 55 387 387 LEU LEU E . n A 1 56 ASN 56 388 388 ASN ASN E . n A 1 57 ASP 57 389 389 ASP ASP E . n A 1 58 LEU 58 390 390 LEU LEU E . n A 1 59 CYS 59 391 391 CYS CYS E . n A 1 60 PHE 60 392 392 PHE PHE E . n A 1 61 THR 61 393 393 THR THR E . n A 1 62 ASN 62 394 394 ASN ASN E . n A 1 63 VAL 63 395 395 VAL VAL E . n A 1 64 TYR 64 396 396 TYR TYR E . n A 1 65 ALA 65 397 397 ALA ALA E . n A 1 66 ASP 66 398 398 ASP ASP E . n A 1 67 SER 67 399 399 SER SER E . n A 1 68 PHE 68 400 400 PHE PHE E . n A 1 69 VAL 69 401 401 VAL VAL E . n A 1 70 ILE 70 402 402 ILE ILE E . n A 1 71 ARG 71 403 403 ARG ARG E . n A 1 72 GLY 72 404 404 GLY GLY E . n A 1 73 ASP 73 405 405 ASP ASP E . n A 1 74 GLU 74 406 406 GLU GLU E . n A 1 75 VAL 75 407 407 VAL VAL E . n A 1 76 ARG 76 408 408 ARG ARG E . n A 1 77 GLN 77 409 409 GLN GLN E . n A 1 78 ILE 78 410 410 ILE ILE E . n A 1 79 ALA 79 411 411 ALA ALA E . n A 1 80 PRO 80 412 412 PRO PRO E . n A 1 81 GLY 81 413 413 GLY GLY E . n A 1 82 GLN 82 414 414 GLN GLN E . n A 1 83 THR 83 415 415 THR THR E . n A 1 84 GLY 84 416 416 GLY GLY E . n A 1 85 LYS 85 417 417 LYS LYS E . n A 1 86 ILE 86 418 418 ILE ILE E . n A 1 87 ALA 87 419 419 ALA ALA E . n A 1 88 ASP 88 420 420 ASP ASP E . n A 1 89 TYR 89 421 421 TYR TYR E . n A 1 90 ASN 90 422 422 ASN ASN E . n A 1 91 TYR 91 423 423 TYR TYR E . n A 1 92 LYS 92 424 424 LYS LYS E . n A 1 93 LEU 93 425 425 LEU LEU E . n A 1 94 PRO 94 426 426 PRO PRO E . n A 1 95 ASP 95 427 427 ASP ASP E . n A 1 96 ASP 96 428 428 ASP ASP E . n A 1 97 PHE 97 429 429 PHE PHE E . n A 1 98 THR 98 430 430 THR THR E . n A 1 99 GLY 99 431 431 GLY GLY E . n A 1 100 CYS 100 432 432 CYS CYS E . n A 1 101 VAL 101 433 433 VAL VAL E . n A 1 102 ILE 102 434 434 ILE ILE E . n A 1 103 ALA 103 435 435 ALA ALA E . n A 1 104 TRP 104 436 436 TRP TRP E . n A 1 105 ASN 105 437 437 ASN ASN E . n A 1 106 SER 106 438 438 SER SER E . n A 1 107 ASN 107 439 439 ASN ASN E . n A 1 108 ASN 108 440 440 ASN ASN E . n A 1 109 LEU 109 441 441 LEU LEU E . n A 1 110 ASP 110 442 442 ASP ASP E . n A 1 111 SER 111 443 443 SER SER E . n A 1 112 LYS 112 444 444 LYS LYS E . n A 1 113 VAL 113 445 445 VAL VAL E . n A 1 114 GLY 114 446 446 GLY GLY E . n A 1 115 GLY 115 447 447 GLY GLY E . n A 1 116 ASN 116 448 448 ASN ASN E . n A 1 117 TYR 117 449 449 TYR TYR E . n A 1 118 ASN 118 450 450 ASN ASN E . n A 1 119 TYR 119 451 451 TYR TYR E . n A 1 120 LEU 120 452 452 LEU LEU E . n A 1 121 TYR 121 453 453 TYR TYR E . n A 1 122 ARG 122 454 454 ARG ARG E . n A 1 123 LEU 123 455 455 LEU LEU E . n A 1 124 PHE 124 456 456 PHE PHE E . n A 1 125 ARG 125 457 457 ARG ARG E . n A 1 126 LYS 126 458 458 LYS LYS E . n A 1 127 SER 127 459 459 SER SER E . n A 1 128 ASN 128 460 460 ASN ASN E . n A 1 129 LEU 129 461 461 LEU LEU E . n A 1 130 LYS 130 462 462 LYS LYS E . n A 1 131 PRO 131 463 463 PRO PRO E . n A 1 132 PHE 132 464 464 PHE PHE E . n A 1 133 GLU 133 465 465 GLU GLU E . n A 1 134 ARG 134 466 466 ARG ARG E . n A 1 135 ASP 135 467 467 ASP ASP E . n A 1 136 ILE 136 468 468 ILE ILE E . n A 1 137 SER 137 469 469 SER SER E . n A 1 138 THR 138 470 470 THR THR E . n A 1 139 GLU 139 471 471 GLU GLU E . n A 1 140 ILE 140 472 472 ILE ILE E . n A 1 141 TYR 141 473 473 TYR TYR E . n A 1 142 GLN 142 474 474 GLN GLN E . n A 1 143 ALA 143 475 475 ALA ALA E . n A 1 144 GLY 144 476 476 GLY GLY E . n A 1 145 SER 145 477 477 SER SER E . n A 1 146 THR 146 478 478 THR THR E . n A 1 147 PRO 147 479 479 PRO PRO E . n A 1 148 CYS 148 480 480 CYS CYS E . n A 1 149 ASN 149 481 481 ASN ASN E . n A 1 150 GLY 150 482 482 GLY GLY E . n A 1 151 VAL 151 483 483 VAL VAL E . n A 1 152 GLU 152 484 484 GLU GLU E . n A 1 153 GLY 153 485 485 GLY GLY E . n A 1 154 PHE 154 486 486 PHE PHE E . n A 1 155 ASN 155 487 487 ASN ASN E . n A 1 156 CYS 156 488 488 CYS CYS E . n A 1 157 TYR 157 489 489 TYR TYR E . n A 1 158 PHE 158 490 490 PHE PHE E . n A 1 159 PRO 159 491 491 PRO PRO E . n A 1 160 LEU 160 492 492 LEU LEU E . n A 1 161 GLN 161 493 493 GLN GLN E . n A 1 162 SER 162 494 494 SER SER E . n A 1 163 TYR 163 495 495 TYR TYR E . n A 1 164 GLY 164 496 496 GLY GLY E . n A 1 165 PHE 165 497 497 PHE PHE E . n A 1 166 GLN 166 498 498 GLN GLN E . n A 1 167 PRO 167 499 499 PRO PRO E . n A 1 168 THR 168 500 500 THR THR E . n A 1 169 ASN 169 501 501 ASN ASN E . n A 1 170 GLY 170 502 502 GLY GLY E . n A 1 171 VAL 171 503 503 VAL VAL E . n A 1 172 GLY 172 504 504 GLY GLY E . n A 1 173 TYR 173 505 505 TYR TYR E . n A 1 174 GLN 174 506 506 GLN GLN E . n A 1 175 PRO 175 507 507 PRO PRO E . n A 1 176 TYR 176 508 508 TYR TYR E . n A 1 177 ARG 177 509 509 ARG ARG E . n A 1 178 VAL 178 510 510 VAL VAL E . n A 1 179 VAL 179 511 511 VAL VAL E . n A 1 180 VAL 180 512 512 VAL VAL E . n A 1 181 LEU 181 513 513 LEU LEU E . n A 1 182 SER 182 514 514 SER SER E . n A 1 183 PHE 183 515 515 PHE PHE E . n A 1 184 GLU 184 516 516 GLU GLU E . n A 1 185 LEU 185 517 517 LEU LEU E . n A 1 186 LEU 186 518 518 LEU LEU E . n A 1 187 HIS 187 519 519 HIS HIS E . n A 1 188 ALA 188 520 520 ALA ALA E . n A 1 189 PRO 189 521 521 PRO PRO E . n A 1 190 ALA 190 522 522 ALA ALA E . n A 1 191 THR 191 523 523 THR THR E . n A 1 192 VAL 192 524 524 VAL VAL E . n A 1 193 CYS 193 525 525 CYS CYS E . n A 1 194 GLY 194 526 526 GLY GLY E . n B 2 1 GLU 1 1 1 GLU GLU H . n B 2 2 VAL 2 2 2 VAL VAL H . n B 2 3 GLN 3 3 3 GLN GLN H . n B 2 4 LEU 4 4 4 LEU LEU H . n B 2 5 VAL 5 5 5 VAL VAL H . n B 2 6 GLU 6 6 6 GLU GLU H . n B 2 7 SER 7 7 7 SER SER H . n B 2 8 GLY 8 8 8 GLY GLY H . n B 2 9 GLY 9 9 9 GLY GLY H . n B 2 10 GLY 10 10 10 GLY GLY H . n B 2 11 VAL 11 11 11 VAL VAL H . n B 2 12 VAL 12 12 12 VAL VAL H . n B 2 13 GLN 13 13 13 GLN GLN H . n B 2 14 PRO 14 14 14 PRO PRO H . n B 2 15 GLY 15 15 15 GLY GLY H . n B 2 16 ARG 16 16 16 ARG ARG H . n B 2 17 SER 17 17 17 SER SER H . n B 2 18 LEU 18 18 18 LEU LEU H . n B 2 19 ARG 19 19 19 ARG ARG H . n B 2 20 LEU 20 20 20 LEU LEU H . n B 2 21 SER 21 21 21 SER SER H . n B 2 22 CYS 22 22 22 CYS CYS H . n B 2 23 ALA 23 23 23 ALA ALA H . n B 2 24 ALA 24 24 24 ALA ALA H . n B 2 25 SER 25 25 25 SER SER H . n B 2 26 ALA 26 26 26 ALA ALA H . n B 2 27 PHE 27 27 27 PHE PHE H . n B 2 28 THR 28 28 28 THR THR H . n B 2 29 PHE 29 29 29 PHE PHE H . n B 2 30 SER 30 30 30 SER SER H . n B 2 31 SER 31 31 31 SER SER H . n B 2 32 TYR 32 32 32 TYR TYR H . n B 2 33 ASP 33 33 33 ASP ASP H . n B 2 34 MET 34 34 34 MET MET H . n B 2 35 HIS 35 35 35 HIS HIS H . n B 2 36 TRP 36 36 36 TRP TRP H . n B 2 37 VAL 37 37 37 VAL VAL H . n B 2 38 ARG 38 38 38 ARG ARG H . n B 2 39 GLN 39 39 39 GLN GLN H . n B 2 40 ALA 40 40 40 ALA ALA H . n B 2 41 PRO 41 41 41 PRO PRO H . n B 2 42 GLY 42 42 42 GLY GLY H . n B 2 43 LYS 43 43 43 LYS LYS H . n B 2 44 GLY 44 44 44 GLY GLY H . n B 2 45 LEU 45 45 45 LEU LEU H . n B 2 46 GLU 46 46 46 GLU GLU H . n B 2 47 TRP 47 47 47 TRP TRP H . n B 2 48 VAL 48 48 48 VAL VAL H . n B 2 49 ALA 49 49 49 ALA ALA H . n B 2 50 VAL 50 50 50 VAL VAL H . n B 2 51 ILE 51 51 51 ILE ILE H . n B 2 52 SER 52 52 52 SER SER H . n B 2 53 TYR 53 53 53 TYR TYR H . n B 2 54 ASP 54 54 54 ASP ASP H . n B 2 55 GLY 55 55 55 GLY GLY H . n B 2 56 SER 56 56 56 SER SER H . n B 2 57 ASN 57 57 57 ASN ASN H . n B 2 58 LYS 58 58 58 LYS LYS H . n B 2 59 TYR 59 59 59 TYR TYR H . n B 2 60 TYR 60 60 60 TYR TYR H . n B 2 61 ALA 61 61 61 ALA ALA H . n B 2 62 ASP 62 62 62 ASP ASP H . n B 2 63 SER 63 63 63 SER SER H . n B 2 64 VAL 64 64 64 VAL VAL H . n B 2 65 LYS 65 65 65 LYS LYS H . n B 2 66 GLY 66 66 66 GLY GLY H . n B 2 67 ARG 67 67 67 ARG ARG H . n B 2 68 PHE 68 68 68 PHE PHE H . n B 2 69 THR 69 69 69 THR THR H . n B 2 70 ILE 70 70 70 ILE ILE H . n B 2 71 SER 71 71 71 SER SER H . n B 2 72 ARG 72 72 72 ARG ARG H . n B 2 73 ASP 73 73 73 ASP ASP H . n B 2 74 ASN 74 74 74 ASN ASN H . n B 2 75 SER 75 75 75 SER SER H . n B 2 76 LYS 76 76 76 LYS LYS H . n B 2 77 ASN 77 77 77 ASN ASN H . n B 2 78 THR 78 78 78 THR THR H . n B 2 79 LEU 79 79 79 LEU LEU H . n B 2 80 TYR 80 80 80 TYR TYR H . n B 2 81 LEU 81 81 81 LEU LEU H . n B 2 82 GLN 82 82 82 GLN GLN H . n B 2 83 MET 83 83 83 MET MET H . n B 2 84 ASN 84 84 84 ASN ASN H . n B 2 85 SER 85 85 85 SER SER H . n B 2 86 LEU 86 86 86 LEU LEU H . n B 2 87 ARG 87 87 87 ARG ARG H . n B 2 88 ALA 88 88 88 ALA ALA H . n B 2 89 GLU 89 89 89 GLU GLU H . n B 2 90 ASP 90 90 90 ASP ASP H . n B 2 91 THR 91 91 91 THR THR H . n B 2 92 ALA 92 92 92 ALA ALA H . n B 2 93 VAL 93 93 93 VAL VAL H . n B 2 94 TYR 94 94 94 TYR TYR H . n B 2 95 TYR 95 95 95 TYR TYR H . n B 2 96 CYS 96 96 96 CYS CYS H . n B 2 97 ALA 97 97 97 ALA ALA H . n B 2 98 LYS 98 98 98 LYS LYS H . n B 2 99 ASP 99 99 99 ASP ASP H . n B 2 100 GLY 100 100 100 GLY GLY H . n B 2 101 GLY 101 101 101 GLY GLY H . n B 2 102 LYS 102 102 102 LYS LYS H . n B 2 103 LEU 103 103 103 LEU LEU H . n B 2 104 TRP 104 104 104 TRP TRP H . n B 2 105 VAL 105 105 105 VAL VAL H . n B 2 106 TYR 106 106 106 TYR TYR H . n B 2 107 TYR 107 107 107 TYR TYR H . n B 2 108 PHE 108 108 108 PHE PHE H . n B 2 109 ASP 109 109 109 ASP ASP H . n B 2 110 TYR 110 110 110 TYR TYR H . n B 2 111 TRP 111 111 111 TRP TRP H . n B 2 112 GLY 112 112 112 GLY GLY H . n B 2 113 GLN 113 113 113 GLN GLN H . n B 2 114 GLY 114 114 114 GLY GLY H . n B 2 115 THR 115 115 115 THR THR H . n B 2 116 LEU 116 116 116 LEU LEU H . n B 2 117 VAL 117 117 117 VAL VAL H . n B 2 118 THR 118 118 118 THR THR H . n B 2 119 VAL 119 119 119 VAL VAL H . n B 2 120 SER 120 120 120 SER SER H . n B 2 121 SER 121 121 121 SER SER H . n B 2 122 ALA 122 122 122 ALA ALA H . n B 2 123 SER 123 123 123 SER SER H . n B 2 124 THR 124 124 124 THR THR H . n B 2 125 LYS 125 125 125 LYS LYS H . n B 2 126 GLY 126 126 126 GLY GLY H . n B 2 127 PRO 127 127 127 PRO PRO H . n B 2 128 SER 128 128 128 SER SER H . n B 2 129 VAL 129 129 129 VAL VAL H . n B 2 130 PHE 130 130 130 PHE PHE H . n B 2 131 PRO 131 131 131 PRO PRO H . n B 2 132 LEU 132 132 132 LEU LEU H . n B 2 133 ALA 133 133 133 ALA ALA H . n B 2 134 PRO 134 134 134 PRO PRO H . n B 2 135 SER 135 135 135 SER SER H . n B 2 136 SER 136 136 136 SER SER H . n B 2 137 LYS 137 137 ? ? ? H . n B 2 138 SER 138 138 ? ? ? H . n B 2 139 THR 139 139 ? ? ? H . n B 2 140 SER 140 140 ? ? ? H . n B 2 141 GLY 141 141 ? ? ? H . n B 2 142 GLY 142 142 142 GLY GLY H . n B 2 143 THR 143 143 143 THR THR H . n B 2 144 ALA 144 144 144 ALA ALA H . n B 2 145 ALA 145 145 145 ALA ALA H . n B 2 146 LEU 146 146 146 LEU LEU H . n B 2 147 GLY 147 147 147 GLY GLY H . n B 2 148 CYS 148 148 148 CYS CYS H . n B 2 149 LEU 149 149 149 LEU LEU H . n B 2 150 VAL 150 150 150 VAL VAL H . n B 2 151 LYS 151 151 151 LYS LYS H . n B 2 152 ASP 152 152 152 ASP ASP H . n B 2 153 TYR 153 153 153 TYR TYR H . n B 2 154 PHE 154 154 154 PHE PHE H . n B 2 155 PRO 155 155 155 PRO PRO H . n B 2 156 GLU 156 156 156 GLU GLU H . n B 2 157 PRO 157 157 157 PRO PRO H . n B 2 158 VAL 158 158 158 VAL VAL H . n B 2 159 THR 159 159 159 THR THR H . n B 2 160 VAL 160 160 160 VAL VAL H . n B 2 161 SER 161 161 161 SER SER H . n B 2 162 TRP 162 162 162 TRP TRP H . n B 2 163 ASN 163 163 163 ASN ASN H . n B 2 164 SER 164 164 164 SER SER H . n B 2 165 GLY 165 165 165 GLY GLY H . n B 2 166 ALA 166 166 166 ALA ALA H . n B 2 167 LEU 167 167 167 LEU LEU H . n B 2 168 THR 168 168 168 THR THR H . n B 2 169 SER 169 169 169 SER SER H . n B 2 170 GLY 170 170 170 GLY GLY H . n B 2 171 VAL 171 171 171 VAL VAL H . n B 2 172 HIS 172 172 172 HIS HIS H . n B 2 173 THR 173 173 173 THR THR H . n B 2 174 PHE 174 174 174 PHE PHE H . n B 2 175 PRO 175 175 175 PRO PRO H . n B 2 176 ALA 176 176 176 ALA ALA H . n B 2 177 VAL 177 177 177 VAL VAL H . n B 2 178 LEU 178 178 178 LEU LEU H . n B 2 179 GLN 179 179 179 GLN GLN H . n B 2 180 SER 180 180 180 SER SER H . n B 2 181 SER 181 181 181 SER SER H . n B 2 182 GLY 182 182 182 GLY GLY H . n B 2 183 LEU 183 183 183 LEU LEU H . n B 2 184 TYR 184 184 184 TYR TYR H . n B 2 185 SER 185 185 185 SER SER H . n B 2 186 LEU 186 186 186 LEU LEU H . n B 2 187 SER 187 187 187 SER SER H . n B 2 188 SER 188 188 188 SER SER H . n B 2 189 VAL 189 189 189 VAL VAL H . n B 2 190 VAL 190 190 190 VAL VAL H . n B 2 191 THR 191 191 191 THR THR H . n B 2 192 VAL 192 192 192 VAL VAL H . n B 2 193 PRO 193 193 193 PRO PRO H . n B 2 194 SER 194 194 194 SER SER H . n B 2 195 SER 195 195 195 SER SER H . n B 2 196 SER 196 196 196 SER SER H . n B 2 197 LEU 197 197 197 LEU LEU H . n B 2 198 GLY 198 198 198 GLY GLY H . n B 2 199 THR 199 199 199 THR THR H . n B 2 200 GLN 200 200 200 GLN GLN H . n B 2 201 THR 201 201 201 THR THR H . n B 2 202 TYR 202 202 202 TYR TYR H . n B 2 203 ILE 203 203 203 ILE ILE H . n B 2 204 CYS 204 204 204 CYS CYS H . n B 2 205 ASN 205 205 205 ASN ASN H . n B 2 206 VAL 206 206 206 VAL VAL H . n B 2 207 ASN 207 207 207 ASN ASN H . n B 2 208 HIS 208 208 208 HIS HIS H . n B 2 209 LYS 209 209 209 LYS LYS H . n B 2 210 PRO 210 210 210 PRO PRO H . n B 2 211 SER 211 211 211 SER SER H . n B 2 212 ASN 212 212 212 ASN ASN H . n B 2 213 THR 213 213 213 THR THR H . n B 2 214 LYS 214 214 214 LYS LYS H . n B 2 215 VAL 215 215 215 VAL VAL H . n B 2 216 ASP 216 216 216 ASP ASP H . n B 2 217 LYS 217 217 217 LYS LYS H . n B 2 218 ARG 218 218 218 ARG ARG H . n B 2 219 VAL 219 219 219 VAL VAL H . n B 2 220 GLU 220 220 220 GLU GLU H . n B 2 221 PRO 221 221 221 PRO PRO H . n B 2 222 LYS 222 222 222 LYS LYS H . n B 2 223 SER 223 223 223 SER SER H . n B 2 224 CYS 224 224 224 CYS CYS H . n B 2 225 ASP 225 225 ? ? ? H . n B 2 226 LYS 226 226 ? ? ? H . n C 3 1 ASP 1 1 1 ASP ASP L . n C 3 2 ILE 2 2 2 ILE ILE L . n C 3 3 GLN 3 3 3 GLN GLN L . n C 3 4 MET 4 4 4 MET MET L . n C 3 5 THR 5 5 5 THR THR L . n C 3 6 GLN 6 6 6 GLN GLN L . n C 3 7 SER 7 7 7 SER SER L . n C 3 8 PRO 8 8 8 PRO PRO L . n C 3 9 SER 9 9 9 SER SER L . n C 3 10 SER 10 10 10 SER SER L . n C 3 11 LEU 11 11 11 LEU LEU L . n C 3 12 SER 12 12 12 SER SER L . n C 3 13 ALA 13 13 13 ALA ALA L . n C 3 14 SER 14 14 14 SER SER L . n C 3 15 VAL 15 15 15 VAL VAL L . n C 3 16 GLY 16 16 16 GLY GLY L . n C 3 17 ASP 17 17 17 ASP ASP L . n C 3 18 ARG 18 18 18 ARG ARG L . n C 3 19 VAL 19 19 19 VAL VAL L . n C 3 20 THR 20 20 20 THR THR L . n C 3 21 ILE 21 21 21 ILE ILE L . n C 3 22 THR 22 22 22 THR THR L . n C 3 23 CYS 23 23 23 CYS CYS L . n C 3 24 ARG 24 24 24 ARG ARG L . n C 3 25 ALA 25 25 25 ALA ALA L . n C 3 26 SER 26 26 26 SER SER L . n C 3 27 GLN 27 27 27 GLN GLN L . n C 3 28 SER 28 28 28 SER SER L . n C 3 29 ILE 29 29 29 ILE ILE L . n C 3 30 SER 30 30 30 SER SER L . n C 3 31 SER 31 31 31 SER SER L . n C 3 32 TYR 32 32 32 TYR TYR L . n C 3 33 LEU 33 33 33 LEU LEU L . n C 3 34 ASN 34 34 34 ASN ASN L . n C 3 35 TRP 35 35 35 TRP TRP L . n C 3 36 TYR 36 36 36 TYR TYR L . n C 3 37 GLN 37 37 37 GLN GLN L . n C 3 38 GLN 38 38 38 GLN GLN L . n C 3 39 LYS 39 39 39 LYS LYS L . n C 3 40 PRO 40 40 40 PRO PRO L . n C 3 41 GLY 41 41 41 GLY GLY L . n C 3 42 LYS 42 42 42 LYS LYS L . n C 3 43 ALA 43 43 43 ALA ALA L . n C 3 44 PRO 44 44 44 PRO PRO L . n C 3 45 LYS 45 45 45 LYS LYS L . n C 3 46 LEU 46 46 46 LEU LEU L . n C 3 47 LEU 47 47 47 LEU LEU L . n C 3 48 ILE 48 48 48 ILE ILE L . n C 3 49 TYR 49 49 49 TYR TYR L . n C 3 50 ALA 50 50 50 ALA ALA L . n C 3 51 ALA 51 51 51 ALA ALA L . n C 3 52 SER 52 52 52 SER SER L . n C 3 53 SER 53 53 53 SER SER L . n C 3 54 LEU 54 54 54 LEU LEU L . n C 3 55 GLN 55 55 55 GLN GLN L . n C 3 56 SER 56 56 56 SER SER L . n C 3 57 GLY 57 57 57 GLY GLY L . n C 3 58 VAL 58 58 58 VAL VAL L . n C 3 59 PRO 59 59 59 PRO PRO L . n C 3 60 SER 60 60 60 SER SER L . n C 3 61 ARG 61 61 61 ARG ARG L . n C 3 62 PHE 62 62 62 PHE PHE L . n C 3 63 SER 63 63 63 SER SER L . n C 3 64 GLY 64 64 64 GLY GLY L . n C 3 65 SER 65 65 65 SER SER L . n C 3 66 GLY 66 66 66 GLY GLY L . n C 3 67 SER 67 67 67 SER SER L . n C 3 68 GLY 68 68 68 GLY GLY L . n C 3 69 THR 69 69 69 THR THR L . n C 3 70 ASP 70 70 70 ASP ASP L . n C 3 71 PHE 71 71 71 PHE PHE L . n C 3 72 THR 72 72 72 THR THR L . n C 3 73 LEU 73 73 73 LEU LEU L . n C 3 74 THR 74 74 74 THR THR L . n C 3 75 ILE 75 75 75 ILE ILE L . n C 3 76 SER 76 76 76 SER SER L . n C 3 77 SER 77 77 77 SER SER L . n C 3 78 LEU 78 78 78 LEU LEU L . n C 3 79 GLN 79 79 79 GLN GLN L . n C 3 80 PRO 80 80 80 PRO PRO L . n C 3 81 GLU 81 81 81 GLU GLU L . n C 3 82 ASP 82 82 82 ASP ASP L . n C 3 83 PHE 83 83 83 PHE PHE L . n C 3 84 ALA 84 84 84 ALA ALA L . n C 3 85 THR 85 85 85 THR THR L . n C 3 86 TYR 86 86 86 TYR TYR L . n C 3 87 TYR 87 87 87 TYR TYR L . n C 3 88 CYS 88 88 88 CYS CYS L . n C 3 89 GLN 89 89 89 GLN GLN L . n C 3 90 GLN 90 90 90 GLN GLN L . n C 3 91 SER 91 91 91 SER SER L . n C 3 92 TYR 92 92 92 TYR TYR L . n C 3 93 SER 93 93 93 SER SER L . n C 3 94 THR 94 94 94 THR THR L . n C 3 95 LEU 95 95 95 LEU LEU L . n C 3 96 ALA 96 96 96 ALA ALA L . n C 3 97 LEU 97 97 97 LEU LEU L . n C 3 98 THR 98 98 98 THR THR L . n C 3 99 PHE 99 99 99 PHE PHE L . n C 3 100 GLY 100 100 100 GLY GLY L . n C 3 101 GLY 101 101 101 GLY GLY L . n C 3 102 GLY 102 102 102 GLY GLY L . n C 3 103 THR 103 103 103 THR THR L . n C 3 104 LYS 104 104 104 LYS LYS L . n C 3 105 VAL 105 105 105 VAL VAL L . n C 3 106 GLU 106 106 106 GLU GLU L . n C 3 107 ILE 107 107 107 ILE ILE L . n C 3 108 LYS 108 108 108 LYS LYS L . n C 3 109 ARG 109 109 109 ARG ARG L . n C 3 110 THR 110 110 110 THR THR L . n C 3 111 VAL 111 111 111 VAL VAL L . n C 3 112 ALA 112 112 112 ALA ALA L . n C 3 113 ALA 113 113 113 ALA ALA L . n C 3 114 PRO 114 114 114 PRO PRO L . n C 3 115 SER 115 115 115 SER SER L . n C 3 116 VAL 116 116 116 VAL VAL L . n C 3 117 PHE 117 117 117 PHE PHE L . n C 3 118 ILE 118 118 118 ILE ILE L . n C 3 119 PHE 119 119 119 PHE PHE L . n C 3 120 PRO 120 120 120 PRO PRO L . n C 3 121 PRO 121 121 121 PRO PRO L . n C 3 122 SER 122 122 122 SER SER L . n C 3 123 ASP 123 123 123 ASP ASP L . n C 3 124 GLU 124 124 124 GLU GLU L . n C 3 125 GLN 125 125 125 GLN GLN L . n C 3 126 LEU 126 126 126 LEU LEU L . n C 3 127 LYS 127 127 127 LYS LYS L . n C 3 128 SER 128 128 128 SER SER L . n C 3 129 GLY 129 129 129 GLY GLY L . n C 3 130 THR 130 130 130 THR THR L . n C 3 131 ALA 131 131 131 ALA ALA L . n C 3 132 SER 132 132 132 SER SER L . n C 3 133 VAL 133 133 133 VAL VAL L . n C 3 134 VAL 134 134 134 VAL VAL L . n C 3 135 CYS 135 135 135 CYS CYS L . n C 3 136 LEU 136 136 136 LEU LEU L . n C 3 137 LEU 137 137 137 LEU LEU L . n C 3 138 ASN 138 138 138 ASN ASN L . n C 3 139 ASN 139 139 139 ASN ASN L . n C 3 140 PHE 140 140 140 PHE PHE L . n C 3 141 TYR 141 141 141 TYR TYR L . n C 3 142 PRO 142 142 142 PRO PRO L . n C 3 143 ARG 143 143 143 ARG ARG L . n C 3 144 GLU 144 144 144 GLU GLU L . n C 3 145 ALA 145 145 145 ALA ALA L . n C 3 146 LYS 146 146 146 LYS LYS L . n C 3 147 VAL 147 147 147 VAL VAL L . n C 3 148 GLN 148 148 148 GLN GLN L . n C 3 149 TRP 149 149 149 TRP TRP L . n C 3 150 LYS 150 150 150 LYS LYS L . n C 3 151 VAL 151 151 151 VAL VAL L . n C 3 152 ASP 152 152 152 ASP ASP L . n C 3 153 ASN 153 153 153 ASN ASN L . n C 3 154 ALA 154 154 154 ALA ALA L . n C 3 155 LEU 155 155 155 LEU LEU L . n C 3 156 GLN 156 156 156 GLN GLN L . n C 3 157 SER 157 157 157 SER SER L . n C 3 158 GLY 158 158 158 GLY GLY L . n C 3 159 ASN 159 159 159 ASN ASN L . n C 3 160 SER 160 160 160 SER SER L . n C 3 161 GLN 161 161 161 GLN GLN L . n C 3 162 GLU 162 162 162 GLU GLU L . n C 3 163 SER 163 163 163 SER SER L . n C 3 164 VAL 164 164 164 VAL VAL L . n C 3 165 THR 165 165 165 THR THR L . n C 3 166 GLU 166 166 166 GLU GLU L . n C 3 167 GLN 167 167 167 GLN GLN L . n C 3 168 ASP 168 168 168 ASP ASP L . n C 3 169 SER 169 169 169 SER SER L . n C 3 170 LYS 170 170 170 LYS LYS L . n C 3 171 ASP 171 171 171 ASP ASP L . n C 3 172 SER 172 172 172 SER SER L . n C 3 173 THR 173 173 173 THR THR L . n C 3 174 TYR 174 174 174 TYR TYR L . n C 3 175 SER 175 175 175 SER SER L . n C 3 176 LEU 176 176 176 LEU LEU L . n C 3 177 SER 177 177 177 SER SER L . n C 3 178 SER 178 178 178 SER SER L . n C 3 179 THR 179 179 179 THR THR L . n C 3 180 LEU 180 180 180 LEU LEU L . n C 3 181 THR 181 181 181 THR THR L . n C 3 182 LEU 182 182 182 LEU LEU L . n C 3 183 SER 183 183 183 SER SER L . n C 3 184 LYS 184 184 184 LYS LYS L . n C 3 185 ALA 185 185 185 ALA ALA L . n C 3 186 ASP 186 186 186 ASP ASP L . n C 3 187 TYR 187 187 187 TYR TYR L . n C 3 188 GLU 188 188 188 GLU GLU L . n C 3 189 LYS 189 189 189 LYS LYS L . n C 3 190 HIS 190 190 190 HIS HIS L . n C 3 191 LYS 191 191 191 LYS LYS L . n C 3 192 VAL 192 192 192 VAL VAL L . n C 3 193 TYR 193 193 193 TYR TYR L . n C 3 194 ALA 194 194 194 ALA ALA L . n C 3 195 CYS 195 195 195 CYS CYS L . n C 3 196 GLU 196 196 196 GLU GLU L . n C 3 197 VAL 197 197 197 VAL VAL L . n C 3 198 THR 198 198 198 THR THR L . n C 3 199 HIS 199 199 199 HIS HIS L . n C 3 200 GLN 200 200 200 GLN GLN L . n C 3 201 GLY 201 201 201 GLY GLY L . n C 3 202 LEU 202 202 202 LEU LEU L . n C 3 203 SER 203 203 203 SER SER L . n C 3 204 SER 204 204 204 SER SER L . n C 3 205 PRO 205 205 205 PRO PRO L . n C 3 206 VAL 206 206 206 VAL VAL L . n C 3 207 THR 207 207 207 THR THR L . n C 3 208 LYS 208 208 208 LYS LYS L . n C 3 209 SER 209 209 209 SER SER L . n C 3 210 PHE 210 210 210 PHE PHE L . n C 3 211 ASN 211 211 211 ASN ASN L . n C 3 212 ARG 212 212 212 ARG ARG L . n C 3 213 GLY 213 213 213 GLY GLY L . n C 3 214 GLU 214 214 214 GLU GLU L . n C 3 215 CYS 215 215 215 CYS CYS L . n D 1 1 THR 1 333 333 THR THR A . n D 1 2 ASN 2 334 334 ASN ASN A . n D 1 3 LEU 3 335 335 LEU LEU A . n D 1 4 CYS 4 336 336 CYS CYS A . n D 1 5 PRO 5 337 337 PRO PRO A . n D 1 6 PHE 6 338 338 PHE PHE A . n D 1 7 GLY 7 339 339 GLY GLY A . n D 1 8 GLU 8 340 340 GLU GLU A . n D 1 9 VAL 9 341 341 VAL VAL A . n D 1 10 PHE 10 342 342 PHE PHE A . n D 1 11 ASN 11 343 343 ASN ASN A . n D 1 12 ALA 12 344 344 ALA ALA A . n D 1 13 THR 13 345 345 THR THR A . n D 1 14 ARG 14 346 346 ARG ARG A . n D 1 15 PHE 15 347 347 PHE PHE A . n D 1 16 ALA 16 348 348 ALA ALA A . n D 1 17 SER 17 349 349 SER SER A . n D 1 18 VAL 18 350 350 VAL VAL A . n D 1 19 TYR 19 351 351 TYR TYR A . n D 1 20 ALA 20 352 352 ALA ALA A . n D 1 21 TRP 21 353 353 TRP TRP A . n D 1 22 ASN 22 354 354 ASN ASN A . n D 1 23 ARG 23 355 355 ARG ARG A . n D 1 24 LYS 24 356 356 LYS LYS A . n D 1 25 ARG 25 357 357 ARG ARG A . n D 1 26 ILE 26 358 358 ILE ILE A . n D 1 27 SER 27 359 359 SER SER A . n D 1 28 ASN 28 360 360 ASN ASN A . n D 1 29 CYS 29 361 361 CYS CYS A . n D 1 30 VAL 30 362 362 VAL VAL A . n D 1 31 ALA 31 363 363 ALA ALA A . n D 1 32 ASP 32 364 364 ASP ASP A . n D 1 33 TYR 33 365 365 TYR TYR A . n D 1 34 SER 34 366 366 SER SER A . n D 1 35 VAL 35 367 367 VAL VAL A . n D 1 36 LEU 36 368 368 LEU LEU A . n D 1 37 TYR 37 369 369 TYR TYR A . n D 1 38 ASN 38 370 370 ASN ASN A . n D 1 39 SER 39 371 371 SER SER A . n D 1 40 ALA 40 372 372 ALA ALA A . n D 1 41 SER 41 373 373 SER SER A . n D 1 42 PHE 42 374 374 PHE PHE A . n D 1 43 SER 43 375 375 SER SER A . n D 1 44 THR 44 376 376 THR THR A . n D 1 45 PHE 45 377 377 PHE PHE A . n D 1 46 LYS 46 378 378 LYS LYS A . n D 1 47 CYS 47 379 379 CYS CYS A . n D 1 48 TYR 48 380 380 TYR TYR A . n D 1 49 GLY 49 381 381 GLY GLY A . n D 1 50 VAL 50 382 382 VAL VAL A . n D 1 51 SER 51 383 383 SER SER A . n D 1 52 PRO 52 384 384 PRO PRO A . n D 1 53 THR 53 385 385 THR THR A . n D 1 54 LYS 54 386 386 LYS LYS A . n D 1 55 LEU 55 387 387 LEU LEU A . n D 1 56 ASN 56 388 388 ASN ASN A . n D 1 57 ASP 57 389 389 ASP ASP A . n D 1 58 LEU 58 390 390 LEU LEU A . n D 1 59 CYS 59 391 391 CYS CYS A . n D 1 60 PHE 60 392 392 PHE PHE A . n D 1 61 THR 61 393 393 THR THR A . n D 1 62 ASN 62 394 394 ASN ASN A . n D 1 63 VAL 63 395 395 VAL VAL A . n D 1 64 TYR 64 396 396 TYR TYR A . n D 1 65 ALA 65 397 397 ALA ALA A . n D 1 66 ASP 66 398 398 ASP ASP A . n D 1 67 SER 67 399 399 SER SER A . n D 1 68 PHE 68 400 400 PHE PHE A . n D 1 69 VAL 69 401 401 VAL VAL A . n D 1 70 ILE 70 402 402 ILE ILE A . n D 1 71 ARG 71 403 403 ARG ARG A . n D 1 72 GLY 72 404 404 GLY GLY A . n D 1 73 ASP 73 405 405 ASP ASP A . n D 1 74 GLU 74 406 406 GLU GLU A . n D 1 75 VAL 75 407 407 VAL VAL A . n D 1 76 ARG 76 408 408 ARG ARG A . n D 1 77 GLN 77 409 409 GLN GLN A . n D 1 78 ILE 78 410 410 ILE ILE A . n D 1 79 ALA 79 411 411 ALA ALA A . n D 1 80 PRO 80 412 412 PRO PRO A . n D 1 81 GLY 81 413 413 GLY GLY A . n D 1 82 GLN 82 414 414 GLN GLN A . n D 1 83 THR 83 415 415 THR THR A . n D 1 84 GLY 84 416 416 GLY GLY A . n D 1 85 LYS 85 417 417 LYS LYS A . n D 1 86 ILE 86 418 418 ILE ILE A . n D 1 87 ALA 87 419 419 ALA ALA A . n D 1 88 ASP 88 420 420 ASP ASP A . n D 1 89 TYR 89 421 421 TYR TYR A . n D 1 90 ASN 90 422 422 ASN ASN A . n D 1 91 TYR 91 423 423 TYR TYR A . n D 1 92 LYS 92 424 424 LYS LYS A . n D 1 93 LEU 93 425 425 LEU LEU A . n D 1 94 PRO 94 426 426 PRO PRO A . n D 1 95 ASP 95 427 427 ASP ASP A . n D 1 96 ASP 96 428 428 ASP ASP A . n D 1 97 PHE 97 429 429 PHE PHE A . n D 1 98 THR 98 430 430 THR THR A . n D 1 99 GLY 99 431 431 GLY GLY A . n D 1 100 CYS 100 432 432 CYS CYS A . n D 1 101 VAL 101 433 433 VAL VAL A . n D 1 102 ILE 102 434 434 ILE ILE A . n D 1 103 ALA 103 435 435 ALA ALA A . n D 1 104 TRP 104 436 436 TRP TRP A . n D 1 105 ASN 105 437 437 ASN ASN A . n D 1 106 SER 106 438 438 SER SER A . n D 1 107 ASN 107 439 439 ASN ASN A . n D 1 108 ASN 108 440 440 ASN ASN A . n D 1 109 LEU 109 441 441 LEU LEU A . n D 1 110 ASP 110 442 442 ASP ASP A . n D 1 111 SER 111 443 443 SER SER A . n D 1 112 LYS 112 444 444 LYS LYS A . n D 1 113 VAL 113 445 445 VAL VAL A . n D 1 114 GLY 114 446 446 GLY GLY A . n D 1 115 GLY 115 447 447 GLY GLY A . n D 1 116 ASN 116 448 448 ASN ASN A . n D 1 117 TYR 117 449 449 TYR TYR A . n D 1 118 ASN 118 450 450 ASN ASN A . n D 1 119 TYR 119 451 451 TYR TYR A . n D 1 120 LEU 120 452 452 LEU LEU A . n D 1 121 TYR 121 453 453 TYR TYR A . n D 1 122 ARG 122 454 454 ARG ARG A . n D 1 123 LEU 123 455 455 LEU LEU A . n D 1 124 PHE 124 456 456 PHE PHE A . n D 1 125 ARG 125 457 457 ARG ARG A . n D 1 126 LYS 126 458 458 LYS LYS A . n D 1 127 SER 127 459 459 SER SER A . n D 1 128 ASN 128 460 460 ASN ASN A . n D 1 129 LEU 129 461 461 LEU LEU A . n D 1 130 LYS 130 462 462 LYS LYS A . n D 1 131 PRO 131 463 463 PRO PRO A . n D 1 132 PHE 132 464 464 PHE PHE A . n D 1 133 GLU 133 465 465 GLU GLU A . n D 1 134 ARG 134 466 466 ARG ARG A . n D 1 135 ASP 135 467 467 ASP ASP A . n D 1 136 ILE 136 468 468 ILE ILE A . n D 1 137 SER 137 469 469 SER SER A . n D 1 138 THR 138 470 470 THR THR A . n D 1 139 GLU 139 471 471 GLU GLU A . n D 1 140 ILE 140 472 472 ILE ILE A . n D 1 141 TYR 141 473 473 TYR TYR A . n D 1 142 GLN 142 474 474 GLN GLN A . n D 1 143 ALA 143 475 475 ALA ALA A . n D 1 144 GLY 144 476 476 GLY GLY A . n D 1 145 SER 145 477 477 SER SER A . n D 1 146 THR 146 478 478 THR THR A . n D 1 147 PRO 147 479 479 PRO PRO A . n D 1 148 CYS 148 480 480 CYS CYS A . n D 1 149 ASN 149 481 481 ASN ASN A . n D 1 150 GLY 150 482 482 GLY GLY A . n D 1 151 VAL 151 483 483 VAL VAL A . n D 1 152 GLU 152 484 484 GLU GLU A . n D 1 153 GLY 153 485 485 GLY GLY A . n D 1 154 PHE 154 486 486 PHE PHE A . n D 1 155 ASN 155 487 487 ASN ASN A . n D 1 156 CYS 156 488 488 CYS CYS A . n D 1 157 TYR 157 489 489 TYR TYR A . n D 1 158 PHE 158 490 490 PHE PHE A . n D 1 159 PRO 159 491 491 PRO PRO A . n D 1 160 LEU 160 492 492 LEU LEU A . n D 1 161 GLN 161 493 493 GLN GLN A . n D 1 162 SER 162 494 494 SER SER A . n D 1 163 TYR 163 495 495 TYR TYR A . n D 1 164 GLY 164 496 496 GLY GLY A . n D 1 165 PHE 165 497 497 PHE PHE A . n D 1 166 GLN 166 498 498 GLN GLN A . n D 1 167 PRO 167 499 499 PRO PRO A . n D 1 168 THR 168 500 500 THR THR A . n D 1 169 ASN 169 501 501 ASN ASN A . n D 1 170 GLY 170 502 502 GLY GLY A . n D 1 171 VAL 171 503 503 VAL VAL A . n D 1 172 GLY 172 504 504 GLY GLY A . n D 1 173 TYR 173 505 505 TYR TYR A . n D 1 174 GLN 174 506 506 GLN GLN A . n D 1 175 PRO 175 507 507 PRO PRO A . n D 1 176 TYR 176 508 508 TYR TYR A . n D 1 177 ARG 177 509 509 ARG ARG A . n D 1 178 VAL 178 510 510 VAL VAL A . n D 1 179 VAL 179 511 511 VAL VAL A . n D 1 180 VAL 180 512 512 VAL VAL A . n D 1 181 LEU 181 513 513 LEU LEU A . n D 1 182 SER 182 514 514 SER SER A . n D 1 183 PHE 183 515 515 PHE PHE A . n D 1 184 GLU 184 516 516 GLU GLU A . n D 1 185 LEU 185 517 517 LEU LEU A . n D 1 186 LEU 186 518 518 LEU LEU A . n D 1 187 HIS 187 519 519 HIS HIS A . n D 1 188 ALA 188 520 520 ALA ALA A . n D 1 189 PRO 189 521 521 PRO PRO A . n D 1 190 ALA 190 522 522 ALA ALA A . n D 1 191 THR 191 523 523 THR THR A . n D 1 192 VAL 192 524 524 VAL VAL A . n D 1 193 CYS 193 525 525 CYS CYS A . n D 1 194 GLY 194 526 526 GLY GLY A . n E 2 1 GLU 1 1 1 GLU GLU B . n E 2 2 VAL 2 2 2 VAL VAL B . n E 2 3 GLN 3 3 3 GLN GLN B . n E 2 4 LEU 4 4 4 LEU LEU B . n E 2 5 VAL 5 5 5 VAL VAL B . n E 2 6 GLU 6 6 6 GLU GLU B . n E 2 7 SER 7 7 7 SER SER B . n E 2 8 GLY 8 8 8 GLY GLY B . n E 2 9 GLY 9 9 9 GLY GLY B . n E 2 10 GLY 10 10 10 GLY GLY B . n E 2 11 VAL 11 11 11 VAL VAL B . n E 2 12 VAL 12 12 12 VAL VAL B . n E 2 13 GLN 13 13 13 GLN GLN B . n E 2 14 PRO 14 14 14 PRO PRO B . n E 2 15 GLY 15 15 15 GLY GLY B . n E 2 16 ARG 16 16 16 ARG ARG B . n E 2 17 SER 17 17 17 SER SER B . n E 2 18 LEU 18 18 18 LEU LEU B . n E 2 19 ARG 19 19 19 ARG ARG B . n E 2 20 LEU 20 20 20 LEU LEU B . n E 2 21 SER 21 21 21 SER SER B . n E 2 22 CYS 22 22 22 CYS CYS B . n E 2 23 ALA 23 23 23 ALA ALA B . n E 2 24 ALA 24 24 24 ALA ALA B . n E 2 25 SER 25 25 25 SER SER B . n E 2 26 ALA 26 26 26 ALA ALA B . n E 2 27 PHE 27 27 27 PHE PHE B . n E 2 28 THR 28 28 28 THR THR B . n E 2 29 PHE 29 29 29 PHE PHE B . n E 2 30 SER 30 30 30 SER SER B . n E 2 31 SER 31 31 31 SER SER B . n E 2 32 TYR 32 32 32 TYR TYR B . n E 2 33 ASP 33 33 33 ASP ASP B . n E 2 34 MET 34 34 34 MET MET B . n E 2 35 HIS 35 35 35 HIS HIS B . n E 2 36 TRP 36 36 36 TRP TRP B . n E 2 37 VAL 37 37 37 VAL VAL B . n E 2 38 ARG 38 38 38 ARG ARG B . n E 2 39 GLN 39 39 39 GLN GLN B . n E 2 40 ALA 40 40 40 ALA ALA B . n E 2 41 PRO 41 41 41 PRO PRO B . n E 2 42 GLY 42 42 42 GLY GLY B . n E 2 43 LYS 43 43 43 LYS LYS B . n E 2 44 GLY 44 44 44 GLY GLY B . n E 2 45 LEU 45 45 45 LEU LEU B . n E 2 46 GLU 46 46 46 GLU GLU B . n E 2 47 TRP 47 47 47 TRP TRP B . n E 2 48 VAL 48 48 48 VAL VAL B . n E 2 49 ALA 49 49 49 ALA ALA B . n E 2 50 VAL 50 50 50 VAL VAL B . n E 2 51 ILE 51 51 51 ILE ILE B . n E 2 52 SER 52 52 52 SER SER B . n E 2 53 TYR 53 53 53 TYR TYR B . n E 2 54 ASP 54 54 54 ASP ASP B . n E 2 55 GLY 55 55 55 GLY GLY B . n E 2 56 SER 56 56 56 SER SER B . n E 2 57 ASN 57 57 57 ASN ASN B . n E 2 58 LYS 58 58 58 LYS LYS B . n E 2 59 TYR 59 59 59 TYR TYR B . n E 2 60 TYR 60 60 60 TYR TYR B . n E 2 61 ALA 61 61 61 ALA ALA B . n E 2 62 ASP 62 62 62 ASP ASP B . n E 2 63 SER 63 63 63 SER SER B . n E 2 64 VAL 64 64 64 VAL VAL B . n E 2 65 LYS 65 65 65 LYS LYS B . n E 2 66 GLY 66 66 66 GLY GLY B . n E 2 67 ARG 67 67 67 ARG ARG B . n E 2 68 PHE 68 68 68 PHE PHE B . n E 2 69 THR 69 69 69 THR THR B . n E 2 70 ILE 70 70 70 ILE ILE B . n E 2 71 SER 71 71 71 SER SER B . n E 2 72 ARG 72 72 72 ARG ARG B . n E 2 73 ASP 73 73 73 ASP ASP B . n E 2 74 ASN 74 74 74 ASN ASN B . n E 2 75 SER 75 75 75 SER SER B . n E 2 76 LYS 76 76 76 LYS LYS B . n E 2 77 ASN 77 77 77 ASN ASN B . n E 2 78 THR 78 78 78 THR THR B . n E 2 79 LEU 79 79 79 LEU LEU B . n E 2 80 TYR 80 80 80 TYR TYR B . n E 2 81 LEU 81 81 81 LEU LEU B . n E 2 82 GLN 82 82 82 GLN GLN B . n E 2 83 MET 83 83 83 MET MET B . n E 2 84 ASN 84 84 84 ASN ASN B . n E 2 85 SER 85 85 85 SER SER B . n E 2 86 LEU 86 86 86 LEU LEU B . n E 2 87 ARG 87 87 87 ARG ARG B . n E 2 88 ALA 88 88 88 ALA ALA B . n E 2 89 GLU 89 89 89 GLU GLU B . n E 2 90 ASP 90 90 90 ASP ASP B . n E 2 91 THR 91 91 91 THR THR B . n E 2 92 ALA 92 92 92 ALA ALA B . n E 2 93 VAL 93 93 93 VAL VAL B . n E 2 94 TYR 94 94 94 TYR TYR B . n E 2 95 TYR 95 95 95 TYR TYR B . n E 2 96 CYS 96 96 96 CYS CYS B . n E 2 97 ALA 97 97 97 ALA ALA B . n E 2 98 LYS 98 98 98 LYS LYS B . n E 2 99 ASP 99 99 99 ASP ASP B . n E 2 100 GLY 100 100 100 GLY GLY B . n E 2 101 GLY 101 101 101 GLY GLY B . n E 2 102 LYS 102 102 102 LYS LYS B . n E 2 103 LEU 103 103 103 LEU LEU B . n E 2 104 TRP 104 104 104 TRP TRP B . n E 2 105 VAL 105 105 105 VAL VAL B . n E 2 106 TYR 106 106 106 TYR TYR B . n E 2 107 TYR 107 107 107 TYR TYR B . n E 2 108 PHE 108 108 108 PHE PHE B . n E 2 109 ASP 109 109 109 ASP ASP B . n E 2 110 TYR 110 110 110 TYR TYR B . n E 2 111 TRP 111 111 111 TRP TRP B . n E 2 112 GLY 112 112 112 GLY GLY B . n E 2 113 GLN 113 113 113 GLN GLN B . n E 2 114 GLY 114 114 114 GLY GLY B . n E 2 115 THR 115 115 115 THR THR B . n E 2 116 LEU 116 116 116 LEU LEU B . n E 2 117 VAL 117 117 117 VAL VAL B . n E 2 118 THR 118 118 118 THR THR B . n E 2 119 VAL 119 119 119 VAL VAL B . n E 2 120 SER 120 120 120 SER SER B . n E 2 121 SER 121 121 121 SER SER B . n E 2 122 ALA 122 122 122 ALA ALA B . n E 2 123 SER 123 123 123 SER SER B . n E 2 124 THR 124 124 124 THR THR B . n E 2 125 LYS 125 125 125 LYS LYS B . n E 2 126 GLY 126 126 126 GLY GLY B . n E 2 127 PRO 127 127 127 PRO PRO B . n E 2 128 SER 128 128 128 SER SER B . n E 2 129 VAL 129 129 129 VAL VAL B . n E 2 130 PHE 130 130 130 PHE PHE B . n E 2 131 PRO 131 131 131 PRO PRO B . n E 2 132 LEU 132 132 132 LEU LEU B . n E 2 133 ALA 133 133 133 ALA ALA B . n E 2 134 PRO 134 134 134 PRO PRO B . n E 2 135 SER 135 135 135 SER SER B . n E 2 136 SER 136 136 136 SER SER B . n E 2 137 LYS 137 137 ? ? ? B . n E 2 138 SER 138 138 ? ? ? B . n E 2 139 THR 139 139 ? ? ? B . n E 2 140 SER 140 140 ? ? ? B . n E 2 141 GLY 141 141 ? ? ? B . n E 2 142 GLY 142 142 142 GLY GLY B . n E 2 143 THR 143 143 143 THR THR B . n E 2 144 ALA 144 144 144 ALA ALA B . n E 2 145 ALA 145 145 145 ALA ALA B . n E 2 146 LEU 146 146 146 LEU LEU B . n E 2 147 GLY 147 147 147 GLY GLY B . n E 2 148 CYS 148 148 148 CYS CYS B . n E 2 149 LEU 149 149 149 LEU LEU B . n E 2 150 VAL 150 150 150 VAL VAL B . n E 2 151 LYS 151 151 151 LYS LYS B . n E 2 152 ASP 152 152 152 ASP ASP B . n E 2 153 TYR 153 153 153 TYR TYR B . n E 2 154 PHE 154 154 154 PHE PHE B . n E 2 155 PRO 155 155 155 PRO PRO B . n E 2 156 GLU 156 156 156 GLU GLU B . n E 2 157 PRO 157 157 157 PRO PRO B . n E 2 158 VAL 158 158 158 VAL VAL B . n E 2 159 THR 159 159 159 THR THR B . n E 2 160 VAL 160 160 160 VAL VAL B . n E 2 161 SER 161 161 161 SER SER B . n E 2 162 TRP 162 162 162 TRP TRP B . n E 2 163 ASN 163 163 163 ASN ASN B . n E 2 164 SER 164 164 164 SER SER B . n E 2 165 GLY 165 165 165 GLY GLY B . n E 2 166 ALA 166 166 166 ALA ALA B . n E 2 167 LEU 167 167 167 LEU LEU B . n E 2 168 THR 168 168 168 THR THR B . n E 2 169 SER 169 169 169 SER SER B . n E 2 170 GLY 170 170 170 GLY GLY B . n E 2 171 VAL 171 171 171 VAL VAL B . n E 2 172 HIS 172 172 172 HIS HIS B . n E 2 173 THR 173 173 173 THR THR B . n E 2 174 PHE 174 174 174 PHE PHE B . n E 2 175 PRO 175 175 175 PRO PRO B . n E 2 176 ALA 176 176 176 ALA ALA B . n E 2 177 VAL 177 177 177 VAL VAL B . n E 2 178 LEU 178 178 178 LEU LEU B . n E 2 179 GLN 179 179 179 GLN GLN B . n E 2 180 SER 180 180 180 SER SER B . n E 2 181 SER 181 181 181 SER SER B . n E 2 182 GLY 182 182 182 GLY GLY B . n E 2 183 LEU 183 183 183 LEU LEU B . n E 2 184 TYR 184 184 184 TYR TYR B . n E 2 185 SER 185 185 185 SER SER B . n E 2 186 LEU 186 186 186 LEU LEU B . n E 2 187 SER 187 187 187 SER SER B . n E 2 188 SER 188 188 188 SER SER B . n E 2 189 VAL 189 189 189 VAL VAL B . n E 2 190 VAL 190 190 190 VAL VAL B . n E 2 191 THR 191 191 191 THR THR B . n E 2 192 VAL 192 192 192 VAL VAL B . n E 2 193 PRO 193 193 193 PRO PRO B . n E 2 194 SER 194 194 194 SER SER B . n E 2 195 SER 195 195 195 SER SER B . n E 2 196 SER 196 196 196 SER SER B . n E 2 197 LEU 197 197 197 LEU LEU B . n E 2 198 GLY 198 198 198 GLY GLY B . n E 2 199 THR 199 199 199 THR THR B . n E 2 200 GLN 200 200 200 GLN GLN B . n E 2 201 THR 201 201 201 THR THR B . n E 2 202 TYR 202 202 202 TYR TYR B . n E 2 203 ILE 203 203 203 ILE ILE B . n E 2 204 CYS 204 204 204 CYS CYS B . n E 2 205 ASN 205 205 205 ASN ASN B . n E 2 206 VAL 206 206 206 VAL VAL B . n E 2 207 ASN 207 207 207 ASN ASN B . n E 2 208 HIS 208 208 208 HIS HIS B . n E 2 209 LYS 209 209 209 LYS LYS B . n E 2 210 PRO 210 210 210 PRO PRO B . n E 2 211 SER 211 211 211 SER SER B . n E 2 212 ASN 212 212 212 ASN ASN B . n E 2 213 THR 213 213 213 THR THR B . n E 2 214 LYS 214 214 214 LYS LYS B . n E 2 215 VAL 215 215 215 VAL VAL B . n E 2 216 ASP 216 216 216 ASP ASP B . n E 2 217 LYS 217 217 217 LYS LYS B . n E 2 218 ARG 218 218 218 ARG ARG B . n E 2 219 VAL 219 219 219 VAL VAL B . n E 2 220 GLU 220 220 220 GLU GLU B . n E 2 221 PRO 221 221 221 PRO PRO B . n E 2 222 LYS 222 222 222 LYS LYS B . n E 2 223 SER 223 223 223 SER SER B . n E 2 224 CYS 224 224 224 CYS CYS B . n E 2 225 ASP 225 225 ? ? ? B . n E 2 226 LYS 226 226 ? ? ? B . n F 3 1 ASP 1 1 1 ASP ASP C . n F 3 2 ILE 2 2 2 ILE ILE C . n F 3 3 GLN 3 3 3 GLN GLN C . n F 3 4 MET 4 4 4 MET MET C . n F 3 5 THR 5 5 5 THR THR C . n F 3 6 GLN 6 6 6 GLN GLN C . n F 3 7 SER 7 7 7 SER SER C . n F 3 8 PRO 8 8 8 PRO PRO C . n F 3 9 SER 9 9 9 SER SER C . n F 3 10 SER 10 10 10 SER SER C . n F 3 11 LEU 11 11 11 LEU LEU C . n F 3 12 SER 12 12 12 SER SER C . n F 3 13 ALA 13 13 13 ALA ALA C . n F 3 14 SER 14 14 14 SER SER C . n F 3 15 VAL 15 15 15 VAL VAL C . n F 3 16 GLY 16 16 16 GLY GLY C . n F 3 17 ASP 17 17 17 ASP ASP C . n F 3 18 ARG 18 18 18 ARG ARG C . n F 3 19 VAL 19 19 19 VAL VAL C . n F 3 20 THR 20 20 20 THR THR C . n F 3 21 ILE 21 21 21 ILE ILE C . n F 3 22 THR 22 22 22 THR THR C . n F 3 23 CYS 23 23 23 CYS CYS C . n F 3 24 ARG 24 24 24 ARG ARG C . n F 3 25 ALA 25 25 25 ALA ALA C . n F 3 26 SER 26 26 26 SER SER C . n F 3 27 GLN 27 27 27 GLN GLN C . n F 3 28 SER 28 28 28 SER SER C . n F 3 29 ILE 29 29 29 ILE ILE C . n F 3 30 SER 30 30 30 SER SER C . n F 3 31 SER 31 31 31 SER SER C . n F 3 32 TYR 32 32 32 TYR TYR C . n F 3 33 LEU 33 33 33 LEU LEU C . n F 3 34 ASN 34 34 34 ASN ASN C . n F 3 35 TRP 35 35 35 TRP TRP C . n F 3 36 TYR 36 36 36 TYR TYR C . n F 3 37 GLN 37 37 37 GLN GLN C . n F 3 38 GLN 38 38 38 GLN GLN C . n F 3 39 LYS 39 39 39 LYS LYS C . n F 3 40 PRO 40 40 40 PRO PRO C . n F 3 41 GLY 41 41 41 GLY GLY C . n F 3 42 LYS 42 42 42 LYS LYS C . n F 3 43 ALA 43 43 43 ALA ALA C . n F 3 44 PRO 44 44 44 PRO PRO C . n F 3 45 LYS 45 45 45 LYS LYS C . n F 3 46 LEU 46 46 46 LEU LEU C . n F 3 47 LEU 47 47 47 LEU LEU C . n F 3 48 ILE 48 48 48 ILE ILE C . n F 3 49 TYR 49 49 49 TYR TYR C . n F 3 50 ALA 50 50 50 ALA ALA C . n F 3 51 ALA 51 51 51 ALA ALA C . n F 3 52 SER 52 52 52 SER SER C . n F 3 53 SER 53 53 53 SER SER C . n F 3 54 LEU 54 54 54 LEU LEU C . n F 3 55 GLN 55 55 55 GLN GLN C . n F 3 56 SER 56 56 56 SER SER C . n F 3 57 GLY 57 57 57 GLY GLY C . n F 3 58 VAL 58 58 58 VAL VAL C . n F 3 59 PRO 59 59 59 PRO PRO C . n F 3 60 SER 60 60 60 SER SER C . n F 3 61 ARG 61 61 61 ARG ARG C . n F 3 62 PHE 62 62 62 PHE PHE C . n F 3 63 SER 63 63 63 SER SER C . n F 3 64 GLY 64 64 64 GLY GLY C . n F 3 65 SER 65 65 65 SER SER C . n F 3 66 GLY 66 66 66 GLY GLY C . n F 3 67 SER 67 67 67 SER SER C . n F 3 68 GLY 68 68 68 GLY GLY C . n F 3 69 THR 69 69 69 THR THR C . n F 3 70 ASP 70 70 70 ASP ASP C . n F 3 71 PHE 71 71 71 PHE PHE C . n F 3 72 THR 72 72 72 THR THR C . n F 3 73 LEU 73 73 73 LEU LEU C . n F 3 74 THR 74 74 74 THR THR C . n F 3 75 ILE 75 75 75 ILE ILE C . n F 3 76 SER 76 76 76 SER SER C . n F 3 77 SER 77 77 77 SER SER C . n F 3 78 LEU 78 78 78 LEU LEU C . n F 3 79 GLN 79 79 79 GLN GLN C . n F 3 80 PRO 80 80 80 PRO PRO C . n F 3 81 GLU 81 81 81 GLU GLU C . n F 3 82 ASP 82 82 82 ASP ASP C . n F 3 83 PHE 83 83 83 PHE PHE C . n F 3 84 ALA 84 84 84 ALA ALA C . n F 3 85 THR 85 85 85 THR THR C . n F 3 86 TYR 86 86 86 TYR TYR C . n F 3 87 TYR 87 87 87 TYR TYR C . n F 3 88 CYS 88 88 88 CYS CYS C . n F 3 89 GLN 89 89 89 GLN GLN C . n F 3 90 GLN 90 90 90 GLN GLN C . n F 3 91 SER 91 91 91 SER SER C . n F 3 92 TYR 92 92 92 TYR TYR C . n F 3 93 SER 93 93 93 SER SER C . n F 3 94 THR 94 94 94 THR THR C . n F 3 95 LEU 95 95 95 LEU LEU C . n F 3 96 ALA 96 96 96 ALA ALA C . n F 3 97 LEU 97 97 97 LEU LEU C . n F 3 98 THR 98 98 98 THR THR C . n F 3 99 PHE 99 99 99 PHE PHE C . n F 3 100 GLY 100 100 100 GLY GLY C . n F 3 101 GLY 101 101 101 GLY GLY C . n F 3 102 GLY 102 102 102 GLY GLY C . n F 3 103 THR 103 103 103 THR THR C . n F 3 104 LYS 104 104 104 LYS LYS C . n F 3 105 VAL 105 105 105 VAL VAL C . n F 3 106 GLU 106 106 106 GLU GLU C . n F 3 107 ILE 107 107 107 ILE ILE C . n F 3 108 LYS 108 108 108 LYS LYS C . n F 3 109 ARG 109 109 109 ARG ARG C . n F 3 110 THR 110 110 110 THR THR C . n F 3 111 VAL 111 111 111 VAL VAL C . n F 3 112 ALA 112 112 112 ALA ALA C . n F 3 113 ALA 113 113 113 ALA ALA C . n F 3 114 PRO 114 114 114 PRO PRO C . n F 3 115 SER 115 115 115 SER SER C . n F 3 116 VAL 116 116 116 VAL VAL C . n F 3 117 PHE 117 117 117 PHE PHE C . n F 3 118 ILE 118 118 118 ILE ILE C . n F 3 119 PHE 119 119 119 PHE PHE C . n F 3 120 PRO 120 120 120 PRO PRO C . n F 3 121 PRO 121 121 121 PRO PRO C . n F 3 122 SER 122 122 122 SER SER C . n F 3 123 ASP 123 123 123 ASP ASP C . n F 3 124 GLU 124 124 124 GLU GLU C . n F 3 125 GLN 125 125 125 GLN GLN C . n F 3 126 LEU 126 126 126 LEU LEU C . n F 3 127 LYS 127 127 127 LYS LYS C . n F 3 128 SER 128 128 128 SER SER C . n F 3 129 GLY 129 129 129 GLY GLY C . n F 3 130 THR 130 130 130 THR THR C . n F 3 131 ALA 131 131 131 ALA ALA C . n F 3 132 SER 132 132 132 SER SER C . n F 3 133 VAL 133 133 133 VAL VAL C . n F 3 134 VAL 134 134 134 VAL VAL C . n F 3 135 CYS 135 135 135 CYS CYS C . n F 3 136 LEU 136 136 136 LEU LEU C . n F 3 137 LEU 137 137 137 LEU LEU C . n F 3 138 ASN 138 138 138 ASN ASN C . n F 3 139 ASN 139 139 139 ASN ASN C . n F 3 140 PHE 140 140 140 PHE PHE C . n F 3 141 TYR 141 141 141 TYR TYR C . n F 3 142 PRO 142 142 142 PRO PRO C . n F 3 143 ARG 143 143 143 ARG ARG C . n F 3 144 GLU 144 144 144 GLU GLU C . n F 3 145 ALA 145 145 145 ALA ALA C . n F 3 146 LYS 146 146 146 LYS LYS C . n F 3 147 VAL 147 147 147 VAL VAL C . n F 3 148 GLN 148 148 148 GLN GLN C . n F 3 149 TRP 149 149 149 TRP TRP C . n F 3 150 LYS 150 150 150 LYS LYS C . n F 3 151 VAL 151 151 151 VAL VAL C . n F 3 152 ASP 152 152 152 ASP ASP C . n F 3 153 ASN 153 153 153 ASN ASN C . n F 3 154 ALA 154 154 154 ALA ALA C . n F 3 155 LEU 155 155 155 LEU LEU C . n F 3 156 GLN 156 156 156 GLN GLN C . n F 3 157 SER 157 157 157 SER SER C . n F 3 158 GLY 158 158 158 GLY GLY C . n F 3 159 ASN 159 159 159 ASN ASN C . n F 3 160 SER 160 160 160 SER SER C . n F 3 161 GLN 161 161 161 GLN GLN C . n F 3 162 GLU 162 162 162 GLU GLU C . n F 3 163 SER 163 163 163 SER SER C . n F 3 164 VAL 164 164 164 VAL VAL C . n F 3 165 THR 165 165 165 THR THR C . n F 3 166 GLU 166 166 166 GLU GLU C . n F 3 167 GLN 167 167 167 GLN GLN C . n F 3 168 ASP 168 168 168 ASP ASP C . n F 3 169 SER 169 169 169 SER SER C . n F 3 170 LYS 170 170 170 LYS LYS C . n F 3 171 ASP 171 171 171 ASP ASP C . n F 3 172 SER 172 172 172 SER SER C . n F 3 173 THR 173 173 173 THR THR C . n F 3 174 TYR 174 174 174 TYR TYR C . n F 3 175 SER 175 175 175 SER SER C . n F 3 176 LEU 176 176 176 LEU LEU C . n F 3 177 SER 177 177 177 SER SER C . n F 3 178 SER 178 178 178 SER SER C . n F 3 179 THR 179 179 179 THR THR C . n F 3 180 LEU 180 180 180 LEU LEU C . n F 3 181 THR 181 181 181 THR THR C . n F 3 182 LEU 182 182 182 LEU LEU C . n F 3 183 SER 183 183 183 SER SER C . n F 3 184 LYS 184 184 184 LYS LYS C . n F 3 185 ALA 185 185 185 ALA ALA C . n F 3 186 ASP 186 186 186 ASP ASP C . n F 3 187 TYR 187 187 187 TYR TYR C . n F 3 188 GLU 188 188 188 GLU GLU C . n F 3 189 LYS 189 189 189 LYS LYS C . n F 3 190 HIS 190 190 190 HIS HIS C . n F 3 191 LYS 191 191 191 LYS LYS C . n F 3 192 VAL 192 192 192 VAL VAL C . n F 3 193 TYR 193 193 193 TYR TYR C . n F 3 194 ALA 194 194 194 ALA ALA C . n F 3 195 CYS 195 195 195 CYS CYS C . n F 3 196 GLU 196 196 196 GLU GLU C . n F 3 197 VAL 197 197 197 VAL VAL C . n F 3 198 THR 198 198 198 THR THR C . n F 3 199 HIS 199 199 199 HIS HIS C . n F 3 200 GLN 200 200 200 GLN GLN C . n F 3 201 GLY 201 201 201 GLY GLY C . n F 3 202 LEU 202 202 202 LEU LEU C . n F 3 203 SER 203 203 203 SER SER C . n F 3 204 SER 204 204 204 SER SER C . n F 3 205 PRO 205 205 205 PRO PRO C . n F 3 206 VAL 206 206 206 VAL VAL C . n F 3 207 THR 207 207 207 THR THR C . n F 3 208 LYS 208 208 208 LYS LYS C . n F 3 209 SER 209 209 209 SER SER C . n F 3 210 PHE 210 210 210 PHE PHE C . n F 3 211 ASN 211 211 211 ASN ASN C . n F 3 212 ARG 212 212 212 ARG ARG C . n F 3 213 GLY 213 213 213 GLY GLY C . n F 3 214 GLU 214 214 214 GLU GLU C . n F 3 215 CYS 215 215 215 CYS CYS C . n G 1 1 THR 1 333 333 THR THR D . n G 1 2 ASN 2 334 334 ASN ASN D . n G 1 3 LEU 3 335 335 LEU LEU D . n G 1 4 CYS 4 336 336 CYS CYS D . n G 1 5 PRO 5 337 337 PRO PRO D . n G 1 6 PHE 6 338 338 PHE PHE D . n G 1 7 GLY 7 339 339 GLY GLY D . n G 1 8 GLU 8 340 340 GLU GLU D . n G 1 9 VAL 9 341 341 VAL VAL D . n G 1 10 PHE 10 342 342 PHE PHE D . n G 1 11 ASN 11 343 343 ASN ASN D . n G 1 12 ALA 12 344 344 ALA ALA D . n G 1 13 THR 13 345 345 THR THR D . n G 1 14 ARG 14 346 346 ARG ARG D . n G 1 15 PHE 15 347 347 PHE PHE D . n G 1 16 ALA 16 348 348 ALA ALA D . n G 1 17 SER 17 349 349 SER SER D . n G 1 18 VAL 18 350 350 VAL VAL D . n G 1 19 TYR 19 351 351 TYR TYR D . n G 1 20 ALA 20 352 352 ALA ALA D . n G 1 21 TRP 21 353 353 TRP TRP D . n G 1 22 ASN 22 354 354 ASN ASN D . n G 1 23 ARG 23 355 355 ARG ARG D . n G 1 24 LYS 24 356 356 LYS LYS D . n G 1 25 ARG 25 357 357 ARG ARG D . n G 1 26 ILE 26 358 358 ILE ILE D . n G 1 27 SER 27 359 359 SER SER D . n G 1 28 ASN 28 360 360 ASN ASN D . n G 1 29 CYS 29 361 361 CYS CYS D . n G 1 30 VAL 30 362 362 VAL VAL D . n G 1 31 ALA 31 363 363 ALA ALA D . n G 1 32 ASP 32 364 364 ASP ASP D . n G 1 33 TYR 33 365 365 TYR TYR D . n G 1 34 SER 34 366 366 SER SER D . n G 1 35 VAL 35 367 367 VAL VAL D . n G 1 36 LEU 36 368 368 LEU LEU D . n G 1 37 TYR 37 369 369 TYR TYR D . n G 1 38 ASN 38 370 370 ASN ASN D . n G 1 39 SER 39 371 371 SER SER D . n G 1 40 ALA 40 372 372 ALA ALA D . n G 1 41 SER 41 373 373 SER SER D . n G 1 42 PHE 42 374 374 PHE PHE D . n G 1 43 SER 43 375 375 SER SER D . n G 1 44 THR 44 376 376 THR THR D . n G 1 45 PHE 45 377 377 PHE PHE D . n G 1 46 LYS 46 378 378 LYS LYS D . n G 1 47 CYS 47 379 379 CYS CYS D . n G 1 48 TYR 48 380 380 TYR TYR D . n G 1 49 GLY 49 381 381 GLY GLY D . n G 1 50 VAL 50 382 382 VAL VAL D . n G 1 51 SER 51 383 383 SER SER D . n G 1 52 PRO 52 384 384 PRO PRO D . n G 1 53 THR 53 385 385 THR THR D . n G 1 54 LYS 54 386 386 LYS LYS D . n G 1 55 LEU 55 387 387 LEU LEU D . n G 1 56 ASN 56 388 388 ASN ASN D . n G 1 57 ASP 57 389 389 ASP ASP D . n G 1 58 LEU 58 390 390 LEU LEU D . n G 1 59 CYS 59 391 391 CYS CYS D . n G 1 60 PHE 60 392 392 PHE PHE D . n G 1 61 THR 61 393 393 THR THR D . n G 1 62 ASN 62 394 394 ASN ASN D . n G 1 63 VAL 63 395 395 VAL VAL D . n G 1 64 TYR 64 396 396 TYR TYR D . n G 1 65 ALA 65 397 397 ALA ALA D . n G 1 66 ASP 66 398 398 ASP ASP D . n G 1 67 SER 67 399 399 SER SER D . n G 1 68 PHE 68 400 400 PHE PHE D . n G 1 69 VAL 69 401 401 VAL VAL D . n G 1 70 ILE 70 402 402 ILE ILE D . n G 1 71 ARG 71 403 403 ARG ARG D . n G 1 72 GLY 72 404 404 GLY GLY D . n G 1 73 ASP 73 405 405 ASP ASP D . n G 1 74 GLU 74 406 406 GLU GLU D . n G 1 75 VAL 75 407 407 VAL VAL D . n G 1 76 ARG 76 408 408 ARG ARG D . n G 1 77 GLN 77 409 409 GLN GLN D . n G 1 78 ILE 78 410 410 ILE ILE D . n G 1 79 ALA 79 411 411 ALA ALA D . n G 1 80 PRO 80 412 412 PRO PRO D . n G 1 81 GLY 81 413 413 GLY GLY D . n G 1 82 GLN 82 414 414 GLN GLN D . n G 1 83 THR 83 415 415 THR THR D . n G 1 84 GLY 84 416 416 GLY GLY D . n G 1 85 LYS 85 417 417 LYS LYS D . n G 1 86 ILE 86 418 418 ILE ILE D . n G 1 87 ALA 87 419 419 ALA ALA D . n G 1 88 ASP 88 420 420 ASP ASP D . n G 1 89 TYR 89 421 421 TYR TYR D . n G 1 90 ASN 90 422 422 ASN ASN D . n G 1 91 TYR 91 423 423 TYR TYR D . n G 1 92 LYS 92 424 424 LYS LYS D . n G 1 93 LEU 93 425 425 LEU LEU D . n G 1 94 PRO 94 426 426 PRO PRO D . n G 1 95 ASP 95 427 427 ASP ASP D . n G 1 96 ASP 96 428 428 ASP ASP D . n G 1 97 PHE 97 429 429 PHE PHE D . n G 1 98 THR 98 430 430 THR THR D . n G 1 99 GLY 99 431 431 GLY GLY D . n G 1 100 CYS 100 432 432 CYS CYS D . n G 1 101 VAL 101 433 433 VAL VAL D . n G 1 102 ILE 102 434 434 ILE ILE D . n G 1 103 ALA 103 435 435 ALA ALA D . n G 1 104 TRP 104 436 436 TRP TRP D . n G 1 105 ASN 105 437 437 ASN ASN D . n G 1 106 SER 106 438 438 SER SER D . n G 1 107 ASN 107 439 439 ASN ASN D . n G 1 108 ASN 108 440 440 ASN ASN D . n G 1 109 LEU 109 441 441 LEU LEU D . n G 1 110 ASP 110 442 442 ASP ASP D . n G 1 111 SER 111 443 443 SER SER D . n G 1 112 LYS 112 444 444 LYS LYS D . n G 1 113 VAL 113 445 445 VAL VAL D . n G 1 114 GLY 114 446 446 GLY GLY D . n G 1 115 GLY 115 447 447 GLY GLY D . n G 1 116 ASN 116 448 448 ASN ASN D . n G 1 117 TYR 117 449 449 TYR TYR D . n G 1 118 ASN 118 450 450 ASN ASN D . n G 1 119 TYR 119 451 451 TYR TYR D . n G 1 120 LEU 120 452 452 LEU LEU D . n G 1 121 TYR 121 453 453 TYR TYR D . n G 1 122 ARG 122 454 454 ARG ARG D . n G 1 123 LEU 123 455 455 LEU LEU D . n G 1 124 PHE 124 456 456 PHE PHE D . n G 1 125 ARG 125 457 457 ARG ARG D . n G 1 126 LYS 126 458 458 LYS LYS D . n G 1 127 SER 127 459 459 SER SER D . n G 1 128 ASN 128 460 460 ASN ASN D . n G 1 129 LEU 129 461 461 LEU LEU D . n G 1 130 LYS 130 462 462 LYS LYS D . n G 1 131 PRO 131 463 463 PRO PRO D . n G 1 132 PHE 132 464 464 PHE PHE D . n G 1 133 GLU 133 465 465 GLU GLU D . n G 1 134 ARG 134 466 466 ARG ARG D . n G 1 135 ASP 135 467 467 ASP ASP D . n G 1 136 ILE 136 468 468 ILE ILE D . n G 1 137 SER 137 469 469 SER SER D . n G 1 138 THR 138 470 470 THR THR D . n G 1 139 GLU 139 471 471 GLU GLU D . n G 1 140 ILE 140 472 472 ILE ILE D . n G 1 141 TYR 141 473 473 TYR TYR D . n G 1 142 GLN 142 474 474 GLN GLN D . n G 1 143 ALA 143 475 475 ALA ALA D . n G 1 144 GLY 144 476 476 GLY GLY D . n G 1 145 SER 145 477 477 SER SER D . n G 1 146 THR 146 478 478 THR THR D . n G 1 147 PRO 147 479 479 PRO PRO D . n G 1 148 CYS 148 480 480 CYS CYS D . n G 1 149 ASN 149 481 481 ASN ASN D . n G 1 150 GLY 150 482 482 GLY GLY D . n G 1 151 VAL 151 483 483 VAL VAL D . n G 1 152 GLU 152 484 484 GLU GLU D . n G 1 153 GLY 153 485 485 GLY GLY D . n G 1 154 PHE 154 486 486 PHE PHE D . n G 1 155 ASN 155 487 487 ASN ASN D . n G 1 156 CYS 156 488 488 CYS CYS D . n G 1 157 TYR 157 489 489 TYR TYR D . n G 1 158 PHE 158 490 490 PHE PHE D . n G 1 159 PRO 159 491 491 PRO PRO D . n G 1 160 LEU 160 492 492 LEU LEU D . n G 1 161 GLN 161 493 493 GLN GLN D . n G 1 162 SER 162 494 494 SER SER D . n G 1 163 TYR 163 495 495 TYR TYR D . n G 1 164 GLY 164 496 496 GLY GLY D . n G 1 165 PHE 165 497 497 PHE PHE D . n G 1 166 GLN 166 498 498 GLN GLN D . n G 1 167 PRO 167 499 499 PRO PRO D . n G 1 168 THR 168 500 500 THR THR D . n G 1 169 ASN 169 501 501 ASN ASN D . n G 1 170 GLY 170 502 502 GLY GLY D . n G 1 171 VAL 171 503 503 VAL VAL D . n G 1 172 GLY 172 504 504 GLY GLY D . n G 1 173 TYR 173 505 505 TYR TYR D . n G 1 174 GLN 174 506 506 GLN GLN D . n G 1 175 PRO 175 507 507 PRO PRO D . n G 1 176 TYR 176 508 508 TYR TYR D . n G 1 177 ARG 177 509 509 ARG ARG D . n G 1 178 VAL 178 510 510 VAL VAL D . n G 1 179 VAL 179 511 511 VAL VAL D . n G 1 180 VAL 180 512 512 VAL VAL D . n G 1 181 LEU 181 513 513 LEU LEU D . n G 1 182 SER 182 514 514 SER SER D . n G 1 183 PHE 183 515 515 PHE PHE D . n G 1 184 GLU 184 516 516 GLU GLU D . n G 1 185 LEU 185 517 517 LEU LEU D . n G 1 186 LEU 186 518 518 LEU LEU D . n G 1 187 HIS 187 519 519 HIS HIS D . n G 1 188 ALA 188 520 520 ALA ALA D . n G 1 189 PRO 189 521 521 PRO PRO D . n G 1 190 ALA 190 522 522 ALA ALA D . n G 1 191 THR 191 523 523 THR THR D . n G 1 192 VAL 192 524 524 VAL VAL D . n G 1 193 CYS 193 525 525 CYS CYS D . n G 1 194 GLY 194 526 526 GLY GLY D . n H 2 1 GLU 1 1 1 GLU GLU F . n H 2 2 VAL 2 2 2 VAL VAL F . n H 2 3 GLN 3 3 3 GLN GLN F . n H 2 4 LEU 4 4 4 LEU LEU F . n H 2 5 VAL 5 5 5 VAL VAL F . n H 2 6 GLU 6 6 6 GLU GLU F . n H 2 7 SER 7 7 7 SER SER F . n H 2 8 GLY 8 8 8 GLY GLY F . n H 2 9 GLY 9 9 9 GLY GLY F . n H 2 10 GLY 10 10 10 GLY GLY F . n H 2 11 VAL 11 11 11 VAL VAL F . n H 2 12 VAL 12 12 12 VAL VAL F . n H 2 13 GLN 13 13 13 GLN GLN F . n H 2 14 PRO 14 14 14 PRO PRO F . n H 2 15 GLY 15 15 15 GLY GLY F . n H 2 16 ARG 16 16 16 ARG ARG F . n H 2 17 SER 17 17 17 SER SER F . n H 2 18 LEU 18 18 18 LEU LEU F . n H 2 19 ARG 19 19 19 ARG ARG F . n H 2 20 LEU 20 20 20 LEU LEU F . n H 2 21 SER 21 21 21 SER SER F . n H 2 22 CYS 22 22 22 CYS CYS F . n H 2 23 ALA 23 23 23 ALA ALA F . n H 2 24 ALA 24 24 24 ALA ALA F . n H 2 25 SER 25 25 25 SER SER F . n H 2 26 ALA 26 26 26 ALA ALA F . n H 2 27 PHE 27 27 27 PHE PHE F . n H 2 28 THR 28 28 28 THR THR F . n H 2 29 PHE 29 29 29 PHE PHE F . n H 2 30 SER 30 30 30 SER SER F . n H 2 31 SER 31 31 31 SER SER F . n H 2 32 TYR 32 32 32 TYR TYR F . n H 2 33 ASP 33 33 33 ASP ASP F . n H 2 34 MET 34 34 34 MET MET F . n H 2 35 HIS 35 35 35 HIS HIS F . n H 2 36 TRP 36 36 36 TRP TRP F . n H 2 37 VAL 37 37 37 VAL VAL F . n H 2 38 ARG 38 38 38 ARG ARG F . n H 2 39 GLN 39 39 39 GLN GLN F . n H 2 40 ALA 40 40 40 ALA ALA F . n H 2 41 PRO 41 41 41 PRO PRO F . n H 2 42 GLY 42 42 42 GLY GLY F . n H 2 43 LYS 43 43 43 LYS LYS F . n H 2 44 GLY 44 44 44 GLY GLY F . n H 2 45 LEU 45 45 45 LEU LEU F . n H 2 46 GLU 46 46 46 GLU GLU F . n H 2 47 TRP 47 47 47 TRP TRP F . n H 2 48 VAL 48 48 48 VAL VAL F . n H 2 49 ALA 49 49 49 ALA ALA F . n H 2 50 VAL 50 50 50 VAL VAL F . n H 2 51 ILE 51 51 51 ILE ILE F . n H 2 52 SER 52 52 52 SER SER F . n H 2 53 TYR 53 53 53 TYR TYR F . n H 2 54 ASP 54 54 54 ASP ASP F . n H 2 55 GLY 55 55 55 GLY GLY F . n H 2 56 SER 56 56 56 SER SER F . n H 2 57 ASN 57 57 57 ASN ASN F . n H 2 58 LYS 58 58 58 LYS LYS F . n H 2 59 TYR 59 59 59 TYR TYR F . n H 2 60 TYR 60 60 60 TYR TYR F . n H 2 61 ALA 61 61 61 ALA ALA F . n H 2 62 ASP 62 62 62 ASP ASP F . n H 2 63 SER 63 63 63 SER SER F . n H 2 64 VAL 64 64 64 VAL VAL F . n H 2 65 LYS 65 65 65 LYS LYS F . n H 2 66 GLY 66 66 66 GLY GLY F . n H 2 67 ARG 67 67 67 ARG ARG F . n H 2 68 PHE 68 68 68 PHE PHE F . n H 2 69 THR 69 69 69 THR THR F . n H 2 70 ILE 70 70 70 ILE ILE F . n H 2 71 SER 71 71 71 SER SER F . n H 2 72 ARG 72 72 72 ARG ARG F . n H 2 73 ASP 73 73 73 ASP ASP F . n H 2 74 ASN 74 74 74 ASN ASN F . n H 2 75 SER 75 75 75 SER SER F . n H 2 76 LYS 76 76 76 LYS LYS F . n H 2 77 ASN 77 77 77 ASN ASN F . n H 2 78 THR 78 78 78 THR THR F . n H 2 79 LEU 79 79 79 LEU LEU F . n H 2 80 TYR 80 80 80 TYR TYR F . n H 2 81 LEU 81 81 81 LEU LEU F . n H 2 82 GLN 82 82 82 GLN GLN F . n H 2 83 MET 83 83 83 MET MET F . n H 2 84 ASN 84 84 84 ASN ASN F . n H 2 85 SER 85 85 85 SER SER F . n H 2 86 LEU 86 86 86 LEU LEU F . n H 2 87 ARG 87 87 87 ARG ARG F . n H 2 88 ALA 88 88 88 ALA ALA F . n H 2 89 GLU 89 89 89 GLU GLU F . n H 2 90 ASP 90 90 90 ASP ASP F . n H 2 91 THR 91 91 91 THR THR F . n H 2 92 ALA 92 92 92 ALA ALA F . n H 2 93 VAL 93 93 93 VAL VAL F . n H 2 94 TYR 94 94 94 TYR TYR F . n H 2 95 TYR 95 95 95 TYR TYR F . n H 2 96 CYS 96 96 96 CYS CYS F . n H 2 97 ALA 97 97 97 ALA ALA F . n H 2 98 LYS 98 98 98 LYS LYS F . n H 2 99 ASP 99 99 99 ASP ASP F . n H 2 100 GLY 100 100 100 GLY GLY F . n H 2 101 GLY 101 101 101 GLY GLY F . n H 2 102 LYS 102 102 102 LYS LYS F . n H 2 103 LEU 103 103 103 LEU LEU F . n H 2 104 TRP 104 104 104 TRP TRP F . n H 2 105 VAL 105 105 105 VAL VAL F . n H 2 106 TYR 106 106 106 TYR TYR F . n H 2 107 TYR 107 107 107 TYR TYR F . n H 2 108 PHE 108 108 108 PHE PHE F . n H 2 109 ASP 109 109 109 ASP ASP F . n H 2 110 TYR 110 110 110 TYR TYR F . n H 2 111 TRP 111 111 111 TRP TRP F . n H 2 112 GLY 112 112 112 GLY GLY F . n H 2 113 GLN 113 113 113 GLN GLN F . n H 2 114 GLY 114 114 114 GLY GLY F . n H 2 115 THR 115 115 115 THR THR F . n H 2 116 LEU 116 116 116 LEU LEU F . n H 2 117 VAL 117 117 117 VAL VAL F . n H 2 118 THR 118 118 118 THR THR F . n H 2 119 VAL 119 119 119 VAL VAL F . n H 2 120 SER 120 120 120 SER SER F . n H 2 121 SER 121 121 121 SER SER F . n H 2 122 ALA 122 122 122 ALA ALA F . n H 2 123 SER 123 123 123 SER SER F . n H 2 124 THR 124 124 124 THR THR F . n H 2 125 LYS 125 125 125 LYS LYS F . n H 2 126 GLY 126 126 126 GLY GLY F . n H 2 127 PRO 127 127 127 PRO PRO F . n H 2 128 SER 128 128 128 SER SER F . n H 2 129 VAL 129 129 129 VAL VAL F . n H 2 130 PHE 130 130 130 PHE PHE F . n H 2 131 PRO 131 131 131 PRO PRO F . n H 2 132 LEU 132 132 132 LEU LEU F . n H 2 133 ALA 133 133 133 ALA ALA F . n H 2 134 PRO 134 134 134 PRO PRO F . n H 2 135 SER 135 135 135 SER SER F . n H 2 136 SER 136 136 136 SER SER F . n H 2 137 LYS 137 137 ? ? ? F . n H 2 138 SER 138 138 ? ? ? F . n H 2 139 THR 139 139 ? ? ? F . n H 2 140 SER 140 140 ? ? ? F . n H 2 141 GLY 141 141 ? ? ? F . n H 2 142 GLY 142 142 142 GLY GLY F . n H 2 143 THR 143 143 143 THR THR F . n H 2 144 ALA 144 144 144 ALA ALA F . n H 2 145 ALA 145 145 145 ALA ALA F . n H 2 146 LEU 146 146 146 LEU LEU F . n H 2 147 GLY 147 147 147 GLY GLY F . n H 2 148 CYS 148 148 148 CYS CYS F . n H 2 149 LEU 149 149 149 LEU LEU F . n H 2 150 VAL 150 150 150 VAL VAL F . n H 2 151 LYS 151 151 151 LYS LYS F . n H 2 152 ASP 152 152 152 ASP ASP F . n H 2 153 TYR 153 153 153 TYR TYR F . n H 2 154 PHE 154 154 154 PHE PHE F . n H 2 155 PRO 155 155 155 PRO PRO F . n H 2 156 GLU 156 156 156 GLU GLU F . n H 2 157 PRO 157 157 157 PRO PRO F . n H 2 158 VAL 158 158 158 VAL VAL F . n H 2 159 THR 159 159 159 THR THR F . n H 2 160 VAL 160 160 160 VAL VAL F . n H 2 161 SER 161 161 161 SER SER F . n H 2 162 TRP 162 162 162 TRP TRP F . n H 2 163 ASN 163 163 163 ASN ASN F . n H 2 164 SER 164 164 164 SER SER F . n H 2 165 GLY 165 165 165 GLY GLY F . n H 2 166 ALA 166 166 166 ALA ALA F . n H 2 167 LEU 167 167 167 LEU LEU F . n H 2 168 THR 168 168 168 THR THR F . n H 2 169 SER 169 169 169 SER SER F . n H 2 170 GLY 170 170 170 GLY GLY F . n H 2 171 VAL 171 171 171 VAL VAL F . n H 2 172 HIS 172 172 172 HIS HIS F . n H 2 173 THR 173 173 173 THR THR F . n H 2 174 PHE 174 174 174 PHE PHE F . n H 2 175 PRO 175 175 175 PRO PRO F . n H 2 176 ALA 176 176 176 ALA ALA F . n H 2 177 VAL 177 177 177 VAL VAL F . n H 2 178 LEU 178 178 178 LEU LEU F . n H 2 179 GLN 179 179 179 GLN GLN F . n H 2 180 SER 180 180 180 SER SER F . n H 2 181 SER 181 181 181 SER SER F . n H 2 182 GLY 182 182 182 GLY GLY F . n H 2 183 LEU 183 183 183 LEU LEU F . n H 2 184 TYR 184 184 184 TYR TYR F . n H 2 185 SER 185 185 185 SER SER F . n H 2 186 LEU 186 186 186 LEU LEU F . n H 2 187 SER 187 187 187 SER SER F . n H 2 188 SER 188 188 188 SER SER F . n H 2 189 VAL 189 189 189 VAL VAL F . n H 2 190 VAL 190 190 190 VAL VAL F . n H 2 191 THR 191 191 191 THR THR F . n H 2 192 VAL 192 192 192 VAL VAL F . n H 2 193 PRO 193 193 193 PRO PRO F . n H 2 194 SER 194 194 194 SER SER F . n H 2 195 SER 195 195 195 SER SER F . n H 2 196 SER 196 196 196 SER SER F . n H 2 197 LEU 197 197 197 LEU LEU F . n H 2 198 GLY 198 198 198 GLY GLY F . n H 2 199 THR 199 199 199 THR THR F . n H 2 200 GLN 200 200 200 GLN GLN F . n H 2 201 THR 201 201 201 THR THR F . n H 2 202 TYR 202 202 202 TYR TYR F . n H 2 203 ILE 203 203 203 ILE ILE F . n H 2 204 CYS 204 204 204 CYS CYS F . n H 2 205 ASN 205 205 205 ASN ASN F . n H 2 206 VAL 206 206 206 VAL VAL F . n H 2 207 ASN 207 207 207 ASN ASN F . n H 2 208 HIS 208 208 208 HIS HIS F . n H 2 209 LYS 209 209 209 LYS LYS F . n H 2 210 PRO 210 210 210 PRO PRO F . n H 2 211 SER 211 211 211 SER SER F . n H 2 212 ASN 212 212 212 ASN ASN F . n H 2 213 THR 213 213 213 THR THR F . n H 2 214 LYS 214 214 214 LYS LYS F . n H 2 215 VAL 215 215 215 VAL VAL F . n H 2 216 ASP 216 216 216 ASP ASP F . n H 2 217 LYS 217 217 217 LYS LYS F . n H 2 218 ARG 218 218 218 ARG ARG F . n H 2 219 VAL 219 219 219 VAL VAL F . n H 2 220 GLU 220 220 220 GLU GLU F . n H 2 221 PRO 221 221 221 PRO PRO F . n H 2 222 LYS 222 222 222 LYS LYS F . n H 2 223 SER 223 223 223 SER SER F . n H 2 224 CYS 224 224 224 CYS CYS F . n H 2 225 ASP 225 225 ? ? ? F . n H 2 226 LYS 226 226 ? ? ? F . n I 3 1 ASP 1 1 1 ASP ASP G . n I 3 2 ILE 2 2 2 ILE ILE G . n I 3 3 GLN 3 3 3 GLN GLN G . n I 3 4 MET 4 4 4 MET MET G . n I 3 5 THR 5 5 5 THR THR G . n I 3 6 GLN 6 6 6 GLN GLN G . n I 3 7 SER 7 7 7 SER SER G . n I 3 8 PRO 8 8 8 PRO PRO G . n I 3 9 SER 9 9 9 SER SER G . n I 3 10 SER 10 10 10 SER SER G . n I 3 11 LEU 11 11 11 LEU LEU G . n I 3 12 SER 12 12 12 SER SER G . n I 3 13 ALA 13 13 13 ALA ALA G . n I 3 14 SER 14 14 14 SER SER G . n I 3 15 VAL 15 15 15 VAL VAL G . n I 3 16 GLY 16 16 16 GLY GLY G . n I 3 17 ASP 17 17 17 ASP ASP G . n I 3 18 ARG 18 18 18 ARG ARG G . n I 3 19 VAL 19 19 19 VAL VAL G . n I 3 20 THR 20 20 20 THR THR G . n I 3 21 ILE 21 21 21 ILE ILE G . n I 3 22 THR 22 22 22 THR THR G . n I 3 23 CYS 23 23 23 CYS CYS G . n I 3 24 ARG 24 24 24 ARG ARG G . n I 3 25 ALA 25 25 25 ALA ALA G . n I 3 26 SER 26 26 26 SER SER G . n I 3 27 GLN 27 27 27 GLN GLN G . n I 3 28 SER 28 28 28 SER SER G . n I 3 29 ILE 29 29 29 ILE ILE G . n I 3 30 SER 30 30 30 SER SER G . n I 3 31 SER 31 31 31 SER SER G . n I 3 32 TYR 32 32 32 TYR TYR G . n I 3 33 LEU 33 33 33 LEU LEU G . n I 3 34 ASN 34 34 34 ASN ASN G . n I 3 35 TRP 35 35 35 TRP TRP G . n I 3 36 TYR 36 36 36 TYR TYR G . n I 3 37 GLN 37 37 37 GLN GLN G . n I 3 38 GLN 38 38 38 GLN GLN G . n I 3 39 LYS 39 39 39 LYS LYS G . n I 3 40 PRO 40 40 40 PRO PRO G . n I 3 41 GLY 41 41 41 GLY GLY G . n I 3 42 LYS 42 42 42 LYS LYS G . n I 3 43 ALA 43 43 43 ALA ALA G . n I 3 44 PRO 44 44 44 PRO PRO G . n I 3 45 LYS 45 45 45 LYS LYS G . n I 3 46 LEU 46 46 46 LEU LEU G . n I 3 47 LEU 47 47 47 LEU LEU G . n I 3 48 ILE 48 48 48 ILE ILE G . n I 3 49 TYR 49 49 49 TYR TYR G . n I 3 50 ALA 50 50 50 ALA ALA G . n I 3 51 ALA 51 51 51 ALA ALA G . n I 3 52 SER 52 52 52 SER SER G . n I 3 53 SER 53 53 53 SER SER G . n I 3 54 LEU 54 54 54 LEU LEU G . n I 3 55 GLN 55 55 55 GLN GLN G . n I 3 56 SER 56 56 56 SER SER G . n I 3 57 GLY 57 57 57 GLY GLY G . n I 3 58 VAL 58 58 58 VAL VAL G . n I 3 59 PRO 59 59 59 PRO PRO G . n I 3 60 SER 60 60 60 SER SER G . n I 3 61 ARG 61 61 61 ARG ARG G . n I 3 62 PHE 62 62 62 PHE PHE G . n I 3 63 SER 63 63 63 SER SER G . n I 3 64 GLY 64 64 64 GLY GLY G . n I 3 65 SER 65 65 65 SER SER G . n I 3 66 GLY 66 66 66 GLY GLY G . n I 3 67 SER 67 67 67 SER SER G . n I 3 68 GLY 68 68 68 GLY GLY G . n I 3 69 THR 69 69 69 THR THR G . n I 3 70 ASP 70 70 70 ASP ASP G . n I 3 71 PHE 71 71 71 PHE PHE G . n I 3 72 THR 72 72 72 THR THR G . n I 3 73 LEU 73 73 73 LEU LEU G . n I 3 74 THR 74 74 74 THR THR G . n I 3 75 ILE 75 75 75 ILE ILE G . n I 3 76 SER 76 76 76 SER SER G . n I 3 77 SER 77 77 77 SER SER G . n I 3 78 LEU 78 78 78 LEU LEU G . n I 3 79 GLN 79 79 79 GLN GLN G . n I 3 80 PRO 80 80 80 PRO PRO G . n I 3 81 GLU 81 81 81 GLU GLU G . n I 3 82 ASP 82 82 82 ASP ASP G . n I 3 83 PHE 83 83 83 PHE PHE G . n I 3 84 ALA 84 84 84 ALA ALA G . n I 3 85 THR 85 85 85 THR THR G . n I 3 86 TYR 86 86 86 TYR TYR G . n I 3 87 TYR 87 87 87 TYR TYR G . n I 3 88 CYS 88 88 88 CYS CYS G . n I 3 89 GLN 89 89 89 GLN GLN G . n I 3 90 GLN 90 90 90 GLN GLN G . n I 3 91 SER 91 91 91 SER SER G . n I 3 92 TYR 92 92 92 TYR TYR G . n I 3 93 SER 93 93 93 SER SER G . n I 3 94 THR 94 94 94 THR THR G . n I 3 95 LEU 95 95 95 LEU LEU G . n I 3 96 ALA 96 96 96 ALA ALA G . n I 3 97 LEU 97 97 97 LEU LEU G . n I 3 98 THR 98 98 98 THR THR G . n I 3 99 PHE 99 99 99 PHE PHE G . n I 3 100 GLY 100 100 100 GLY GLY G . n I 3 101 GLY 101 101 101 GLY GLY G . n I 3 102 GLY 102 102 102 GLY GLY G . n I 3 103 THR 103 103 103 THR THR G . n I 3 104 LYS 104 104 104 LYS LYS G . n I 3 105 VAL 105 105 105 VAL VAL G . n I 3 106 GLU 106 106 106 GLU GLU G . n I 3 107 ILE 107 107 107 ILE ILE G . n I 3 108 LYS 108 108 108 LYS LYS G . n I 3 109 ARG 109 109 109 ARG ARG G . n I 3 110 THR 110 110 110 THR THR G . n I 3 111 VAL 111 111 111 VAL VAL G . n I 3 112 ALA 112 112 112 ALA ALA G . n I 3 113 ALA 113 113 113 ALA ALA G . n I 3 114 PRO 114 114 114 PRO PRO G . n I 3 115 SER 115 115 115 SER SER G . n I 3 116 VAL 116 116 116 VAL VAL G . n I 3 117 PHE 117 117 117 PHE PHE G . n I 3 118 ILE 118 118 118 ILE ILE G . n I 3 119 PHE 119 119 119 PHE PHE G . n I 3 120 PRO 120 120 120 PRO PRO G . n I 3 121 PRO 121 121 121 PRO PRO G . n I 3 122 SER 122 122 122 SER SER G . n I 3 123 ASP 123 123 123 ASP ASP G . n I 3 124 GLU 124 124 124 GLU GLU G . n I 3 125 GLN 125 125 125 GLN GLN G . n I 3 126 LEU 126 126 126 LEU LEU G . n I 3 127 LYS 127 127 127 LYS LYS G . n I 3 128 SER 128 128 128 SER SER G . n I 3 129 GLY 129 129 129 GLY GLY G . n I 3 130 THR 130 130 130 THR THR G . n I 3 131 ALA 131 131 131 ALA ALA G . n I 3 132 SER 132 132 132 SER SER G . n I 3 133 VAL 133 133 133 VAL VAL G . n I 3 134 VAL 134 134 134 VAL VAL G . n I 3 135 CYS 135 135 135 CYS CYS G . n I 3 136 LEU 136 136 136 LEU LEU G . n I 3 137 LEU 137 137 137 LEU LEU G . n I 3 138 ASN 138 138 138 ASN ASN G . n I 3 139 ASN 139 139 139 ASN ASN G . n I 3 140 PHE 140 140 140 PHE PHE G . n I 3 141 TYR 141 141 141 TYR TYR G . n I 3 142 PRO 142 142 142 PRO PRO G . n I 3 143 ARG 143 143 143 ARG ARG G . n I 3 144 GLU 144 144 144 GLU GLU G . n I 3 145 ALA 145 145 145 ALA ALA G . n I 3 146 LYS 146 146 146 LYS LYS G . n I 3 147 VAL 147 147 147 VAL VAL G . n I 3 148 GLN 148 148 148 GLN GLN G . n I 3 149 TRP 149 149 149 TRP TRP G . n I 3 150 LYS 150 150 150 LYS LYS G . n I 3 151 VAL 151 151 151 VAL VAL G . n I 3 152 ASP 152 152 152 ASP ASP G . n I 3 153 ASN 153 153 153 ASN ASN G . n I 3 154 ALA 154 154 154 ALA ALA G . n I 3 155 LEU 155 155 155 LEU LEU G . n I 3 156 GLN 156 156 156 GLN GLN G . n I 3 157 SER 157 157 157 SER SER G . n I 3 158 GLY 158 158 158 GLY GLY G . n I 3 159 ASN 159 159 159 ASN ASN G . n I 3 160 SER 160 160 160 SER SER G . n I 3 161 GLN 161 161 161 GLN GLN G . n I 3 162 GLU 162 162 162 GLU GLU G . n I 3 163 SER 163 163 163 SER SER G . n I 3 164 VAL 164 164 164 VAL VAL G . n I 3 165 THR 165 165 165 THR THR G . n I 3 166 GLU 166 166 166 GLU GLU G . n I 3 167 GLN 167 167 167 GLN GLN G . n I 3 168 ASP 168 168 168 ASP ASP G . n I 3 169 SER 169 169 169 SER SER G . n I 3 170 LYS 170 170 170 LYS LYS G . n I 3 171 ASP 171 171 171 ASP ASP G . n I 3 172 SER 172 172 172 SER SER G . n I 3 173 THR 173 173 173 THR THR G . n I 3 174 TYR 174 174 174 TYR TYR G . n I 3 175 SER 175 175 175 SER SER G . n I 3 176 LEU 176 176 176 LEU LEU G . n I 3 177 SER 177 177 177 SER SER G . n I 3 178 SER 178 178 178 SER SER G . n I 3 179 THR 179 179 179 THR THR G . n I 3 180 LEU 180 180 180 LEU LEU G . n I 3 181 THR 181 181 181 THR THR G . n I 3 182 LEU 182 182 182 LEU LEU G . n I 3 183 SER 183 183 183 SER SER G . n I 3 184 LYS 184 184 184 LYS LYS G . n I 3 185 ALA 185 185 185 ALA ALA G . n I 3 186 ASP 186 186 186 ASP ASP G . n I 3 187 TYR 187 187 187 TYR TYR G . n I 3 188 GLU 188 188 188 GLU GLU G . n I 3 189 LYS 189 189 189 LYS LYS G . n I 3 190 HIS 190 190 190 HIS HIS G . n I 3 191 LYS 191 191 191 LYS LYS G . n I 3 192 VAL 192 192 192 VAL VAL G . n I 3 193 TYR 193 193 193 TYR TYR G . n I 3 194 ALA 194 194 194 ALA ALA G . n I 3 195 CYS 195 195 195 CYS CYS G . n I 3 196 GLU 196 196 196 GLU GLU G . n I 3 197 VAL 197 197 197 VAL VAL G . n I 3 198 THR 198 198 198 THR THR G . n I 3 199 HIS 199 199 199 HIS HIS G . n I 3 200 GLN 200 200 200 GLN GLN G . n I 3 201 GLY 201 201 201 GLY GLY G . n I 3 202 LEU 202 202 202 LEU LEU G . n I 3 203 SER 203 203 203 SER SER G . n I 3 204 SER 204 204 204 SER SER G . n I 3 205 PRO 205 205 205 PRO PRO G . n I 3 206 VAL 206 206 206 VAL VAL G . n I 3 207 THR 207 207 207 THR THR G . n I 3 208 LYS 208 208 208 LYS LYS G . n I 3 209 SER 209 209 209 SER SER G . n I 3 210 PHE 210 210 210 PHE PHE G . n I 3 211 ASN 211 211 211 ASN ASN G . n I 3 212 ARG 212 212 212 ARG ARG G . n I 3 213 GLY 213 213 213 GLY GLY G . n I 3 214 GLU 214 214 214 GLU GLU G . n I 3 215 CYS 215 215 215 CYS CYS G . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code J 4 NAG 1 601 601 NAG NAG E . K 4 NAG 1 601 601 NAG NAG A . L 4 NAG 1 601 601 NAG NAG D . # _software.citation_id ? _software.classification refinement _software.compiler_name ? _software.compiler_version ? _software.contact_author ? _software.contact_author_email ? _software.date ? _software.description ? _software.dependencies ? _software.hardware ? _software.language ? _software.location ? _software.mods ? _software.name PHENIX _software.os ? _software.os_version ? _software.type ? _software.version 1.18.1_3865: _software.pdbx_ordinal 1 # _cell.angle_alpha 90.00 _cell.angle_alpha_esd ? _cell.angle_beta 90.00 _cell.angle_beta_esd ? _cell.angle_gamma 90.00 _cell.angle_gamma_esd ? _cell.entry_id 6ZDG _cell.details ? _cell.formula_units_Z ? _cell.length_a 1.00 _cell.length_a_esd ? _cell.length_b 1.00 _cell.length_b_esd ? _cell.length_c 1.00 _cell.length_c_esd ? _cell.volume ? _cell.volume_esd ? _cell.Z_PDB ? _cell.reciprocal_angle_alpha ? _cell.reciprocal_angle_beta ? _cell.reciprocal_angle_gamma ? _cell.reciprocal_angle_alpha_esd ? _cell.reciprocal_angle_beta_esd ? _cell.reciprocal_angle_gamma_esd ? _cell.reciprocal_length_a ? _cell.reciprocal_length_b ? _cell.reciprocal_length_c ? _cell.reciprocal_length_a_esd ? _cell.reciprocal_length_b_esd ? _cell.reciprocal_length_c_esd ? _cell.pdbx_unique_axis ? # _symmetry.entry_id 6ZDG _symmetry.cell_setting ? _symmetry.Int_Tables_number 1 _symmetry.space_group_name_Hall ? _symmetry.space_group_name_H-M 'P 1' _symmetry.pdbx_full_space_group_name_H-M ? # _exptl.absorpt_coefficient_mu ? _exptl.absorpt_correction_T_max ? _exptl.absorpt_correction_T_min ? _exptl.absorpt_correction_type ? _exptl.absorpt_process_details ? _exptl.entry_id 6ZDG _exptl.crystals_number ? _exptl.details ? _exptl.method 'ELECTRON MICROSCOPY' _exptl.method_details ? # _refine.pdbx_refine_id 'ELECTRON MICROSCOPY' _refine.entry_id 6ZDG _refine.pdbx_diffrn_id ? _refine.pdbx_TLS_residual_ADP_flag ? _refine.ls_number_reflns_obs ? _refine.ls_number_reflns_all ? _refine.pdbx_ls_sigma_I ? _refine.pdbx_ls_sigma_F ? _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.ls_d_res_low ? _refine.ls_d_res_high . _refine.ls_percent_reflns_obs ? _refine.ls_R_factor_obs ? _refine.ls_R_factor_all ? _refine.ls_R_factor_R_work ? _refine.ls_R_factor_R_free ? _refine.ls_R_factor_R_free_error ? _refine.ls_R_factor_R_free_error_details ? _refine.ls_percent_reflns_R_free ? _refine.ls_number_reflns_R_free ? _refine.ls_number_parameters ? _refine.ls_number_restraints ? _refine.occupancy_min ? _refine.occupancy_max ? _refine.correlation_coeff_Fo_to_Fc ? _refine.correlation_coeff_Fo_to_Fc_free ? _refine.B_iso_mean ? _refine.aniso_B[1][1] ? _refine.aniso_B[2][2] ? _refine.aniso_B[3][3] ? _refine.aniso_B[1][2] ? _refine.aniso_B[1][3] ? _refine.aniso_B[2][3] ? _refine.solvent_model_details ? _refine.solvent_model_param_ksol ? _refine.solvent_model_param_bsol ? _refine.pdbx_solvent_vdw_probe_radii ? _refine.pdbx_solvent_ion_probe_radii ? _refine.pdbx_solvent_shrinkage_radii ? _refine.pdbx_ls_cross_valid_method ? _refine.details ? _refine.pdbx_starting_model ? _refine.pdbx_method_to_determine_struct ? _refine.pdbx_isotropic_thermal_model ? _refine.pdbx_stereochemistry_target_values ? _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_R_Free_selection_details ? _refine.pdbx_overall_ESU_R ? _refine.pdbx_overall_ESU_R_Free ? _refine.overall_SU_ML ? _refine.pdbx_overall_phase_error ? _refine.overall_SU_B ? _refine.overall_SU_R_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? # loop_ _refine_ls_restr.pdbx_refine_id _refine_ls_restr.criterion _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.number _refine_ls_restr.rejects _refine_ls_restr.type _refine_ls_restr.weight _refine_ls_restr.pdbx_restraint_function 'ELECTRON MICROSCOPY' ? 0.003 ? 14907 ? f_bond_d ? ? 'ELECTRON MICROSCOPY' ? 0.475 ? 20271 ? f_angle_d ? ? 'ELECTRON MICROSCOPY' ? 10.839 ? 5295 ? f_dihedral_angle_d ? ? 'ELECTRON MICROSCOPY' ? 0.041 ? 2244 ? f_chiral_restr ? ? 'ELECTRON MICROSCOPY' ? 0.003 ? 2601 ? f_plane_restr ? ? # _struct.entry_id 6ZDG _struct.title 'Association of three complexes of largely structurally disordered Spike ectodomain with bound EY6A Fab' _struct.pdbx_model_details ? _struct.pdbx_formula_weight ? _struct.pdbx_formula_weight_method ? _struct.pdbx_model_type_details ? _struct.pdbx_CASP_flag N # _struct_keywords.entry_id 6ZDG _struct_keywords.text 'EY6a, RBD, Spike glycoprotein, SARS-CoV-2, human neutralizing antibody, VIRAL PROTEIN' _struct_keywords.pdbx_keywords 'VIRAL PROTEIN' # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 2 ? C N N 3 ? D N N 1 ? E N N 2 ? F N N 3 ? G N N 1 ? H N N 2 ? I N N 3 ? J N N 4 ? K N N 4 ? L N N 4 ? # loop_ _struct_ref.id _struct_ref.db_name _struct_ref.db_code _struct_ref.pdbx_db_accession _struct_ref.pdbx_db_isoform _struct_ref.entity_id _struct_ref.pdbx_seq_one_letter_code _struct_ref.pdbx_align_begin 1 UNP SPIKE_SARS2 P0DTC2 ? 1 ;TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAP GQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPL QSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCG ; 333 2 PDB 6ZDG 6ZDG ? 2 ? 1 3 PDB 6ZDG 6ZDG ? 3 ? 1 # loop_ _struct_ref_seq.align_id _struct_ref_seq.ref_id _struct_ref_seq.pdbx_PDB_id_code _struct_ref_seq.pdbx_strand_id _struct_ref_seq.seq_align_beg _struct_ref_seq.pdbx_seq_align_beg_ins_code _struct_ref_seq.seq_align_end _struct_ref_seq.pdbx_seq_align_end_ins_code _struct_ref_seq.pdbx_db_accession _struct_ref_seq.db_align_beg _struct_ref_seq.pdbx_db_align_beg_ins_code _struct_ref_seq.db_align_end _struct_ref_seq.pdbx_db_align_end_ins_code _struct_ref_seq.pdbx_auth_seq_align_beg _struct_ref_seq.pdbx_auth_seq_align_end 1 1 6ZDG E 1 ? 194 ? P0DTC2 333 ? 526 ? 333 526 2 2 6ZDG H 1 ? 226 ? 6ZDG 1 ? 226 ? 1 226 3 3 6ZDG L 1 ? 215 ? 6ZDG 1 ? 215 ? 1 215 4 1 6ZDG A 1 ? 194 ? P0DTC2 333 ? 526 ? 333 526 5 2 6ZDG B 1 ? 226 ? 6ZDG 1 ? 226 ? 1 226 6 3 6ZDG C 1 ? 215 ? 6ZDG 1 ? 215 ? 1 215 7 1 6ZDG D 1 ? 194 ? P0DTC2 333 ? 526 ? 333 526 8 2 6ZDG F 1 ? 226 ? 6ZDG 1 ? 226 ? 1 226 9 3 6ZDG G 1 ? 215 ? 6ZDG 1 ? 215 ? 1 215 # _pdbx_struct_assembly.id 1 _pdbx_struct_assembly.details author_defined_assembly _pdbx_struct_assembly.method_details ? _pdbx_struct_assembly.oligomeric_details nonameric _pdbx_struct_assembly.oligomeric_count 9 # _pdbx_struct_assembly_gen.assembly_id 1 _pdbx_struct_assembly_gen.oper_expression 1 _pdbx_struct_assembly_gen.asym_id_list A,B,C,D,E,F,G,H,I,J,K,L # _pdbx_struct_assembly_auth_evidence.id 1 _pdbx_struct_assembly_auth_evidence.assembly_id 1 _pdbx_struct_assembly_auth_evidence.experimental_support microscopy _pdbx_struct_assembly_auth_evidence.details ? # _pdbx_struct_oper_list.id 1 _pdbx_struct_oper_list.type 'identity operation' _pdbx_struct_oper_list.name 1_555 _pdbx_struct_oper_list.symmetry_operation ? _pdbx_struct_oper_list.matrix[1][1] 1.0000000000 _pdbx_struct_oper_list.matrix[1][2] 0.0000000000 _pdbx_struct_oper_list.matrix[1][3] 0.0000000000 _pdbx_struct_oper_list.vector[1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][2] 1.0000000000 _pdbx_struct_oper_list.matrix[2][3] 0.0000000000 _pdbx_struct_oper_list.vector[2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][1] 0.0000000000 _pdbx_struct_oper_list.matrix[3][2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][3] 1.0000000000 _pdbx_struct_oper_list.vector[3] 0.0000000000 # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 AA1 PHE A 6 ? ASN A 11 ? PHE E 338 ASN E 343 1 ? 6 HELX_P HELX_P2 AA2 TYR A 33 ? SER A 39 ? TYR E 365 SER E 371 1 ? 7 HELX_P HELX_P3 AA3 PRO A 52 ? ASN A 56 ? PRO E 384 ASN E 388 5 ? 5 HELX_P HELX_P4 AA4 ASP A 73 ? ILE A 78 ? ASP E 405 ILE E 410 5 ? 6 HELX_P HELX_P5 AA5 GLY A 84 ? ASN A 90 ? GLY E 416 ASN E 422 1 ? 7 HELX_P HELX_P6 AA6 THR B 28 ? TYR B 32 ? THR H 28 TYR H 32 5 ? 5 HELX_P HELX_P7 AA7 ARG B 87 ? THR B 91 ? ARG H 87 THR H 91 5 ? 5 HELX_P HELX_P8 AA8 SER B 164 ? ALA B 166 ? SER H 164 ALA H 166 5 ? 3 HELX_P HELX_P9 AA9 GLN C 79 ? PHE C 83 ? GLN L 79 PHE L 83 5 ? 5 HELX_P HELX_P10 AB1 SER C 93 ? LEU C 97 ? SER L 93 LEU L 97 5 ? 5 HELX_P HELX_P11 AB2 SER C 122 ? GLY C 129 ? SER L 122 GLY L 129 1 ? 8 HELX_P HELX_P12 AB3 LYS C 184 ? LYS C 189 ? LYS L 184 LYS L 189 1 ? 6 HELX_P HELX_P13 AB4 PHE D 6 ? ASN D 11 ? PHE A 338 ASN A 343 1 ? 6 HELX_P HELX_P14 AB5 TYR D 33 ? SER D 39 ? TYR A 365 SER A 371 1 ? 7 HELX_P HELX_P15 AB6 PRO D 52 ? ASN D 56 ? PRO A 384 ASN A 388 5 ? 5 HELX_P HELX_P16 AB7 ASP D 73 ? ILE D 78 ? ASP A 405 ILE A 410 5 ? 6 HELX_P HELX_P17 AB8 GLY D 84 ? ASN D 90 ? GLY A 416 ASN A 422 1 ? 7 HELX_P HELX_P18 AB9 THR E 28 ? TYR E 32 ? THR B 28 TYR B 32 5 ? 5 HELX_P HELX_P19 AC1 ARG E 87 ? THR E 91 ? ARG B 87 THR B 91 5 ? 5 HELX_P HELX_P20 AC2 SER E 164 ? ALA E 166 ? SER B 164 ALA B 166 5 ? 3 HELX_P HELX_P21 AC3 GLN F 79 ? PHE F 83 ? GLN C 79 PHE C 83 5 ? 5 HELX_P HELX_P22 AC4 SER F 93 ? LEU F 97 ? SER C 93 LEU C 97 5 ? 5 HELX_P HELX_P23 AC5 SER F 122 ? GLY F 129 ? SER C 122 GLY C 129 1 ? 8 HELX_P HELX_P24 AC6 LYS F 184 ? LYS F 189 ? LYS C 184 LYS C 189 1 ? 6 HELX_P HELX_P25 AC7 PHE G 6 ? ASN G 11 ? PHE D 338 ASN D 343 1 ? 6 HELX_P HELX_P26 AC8 TYR G 33 ? SER G 39 ? TYR D 365 SER D 371 1 ? 7 HELX_P HELX_P27 AC9 PRO G 52 ? ASN G 56 ? PRO D 384 ASN D 388 5 ? 5 HELX_P HELX_P28 AD1 ASP G 73 ? ILE G 78 ? ASP D 405 ILE D 410 5 ? 6 HELX_P HELX_P29 AD2 GLY G 84 ? ASN G 90 ? GLY D 416 ASN D 422 1 ? 7 HELX_P HELX_P30 AD3 THR H 28 ? TYR H 32 ? THR F 28 TYR F 32 5 ? 5 HELX_P HELX_P31 AD4 ARG H 87 ? THR H 91 ? ARG F 87 THR F 91 5 ? 5 HELX_P HELX_P32 AD5 SER H 164 ? ALA H 166 ? SER F 164 ALA F 166 5 ? 3 HELX_P HELX_P33 AD6 GLN I 79 ? PHE I 83 ? GLN G 79 PHE G 83 5 ? 5 HELX_P HELX_P34 AD7 SER I 93 ? LEU I 97 ? SER G 93 LEU G 97 5 ? 5 HELX_P HELX_P35 AD8 SER I 122 ? GLY I 129 ? SER G 122 GLY G 129 1 ? 8 HELX_P HELX_P36 AD9 LYS I 184 ? LYS I 189 ? LYS G 184 LYS G 189 1 ? 6 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order _struct_conn.pdbx_role disulf1 disulf ? ? A CYS 4 SG ? ? ? 1_555 A CYS 29 SG ? ? E CYS 336 E CYS 361 1_555 ? ? ? ? ? ? ? 2.031 ? ? disulf2 disulf ? ? A CYS 47 SG ? ? ? 1_555 A CYS 100 SG ? ? E CYS 379 E CYS 432 1_555 ? ? ? ? ? ? ? 2.030 ? ? disulf3 disulf ? ? A CYS 59 SG ? ? ? 1_555 A CYS 193 SG ? ? E CYS 391 E CYS 525 1_555 ? ? ? ? ? ? ? 2.033 ? ? disulf4 disulf ? ? A CYS 148 SG ? ? ? 1_555 A CYS 156 SG ? ? E CYS 480 E CYS 488 1_555 ? ? ? ? ? ? ? 2.031 ? ? disulf5 disulf ? ? B CYS 22 SG ? ? ? 1_555 B CYS 96 SG ? ? H CYS 22 H CYS 96 1_555 ? ? ? ? ? ? ? 2.029 ? ? disulf6 disulf ? ? B CYS 148 SG ? ? ? 1_555 B CYS 204 SG ? ? H CYS 148 H CYS 204 1_555 ? ? ? ? ? ? ? 2.031 ? ? disulf7 disulf ? ? B CYS 224 SG ? ? ? 1_555 C CYS 215 SG ? ? H CYS 224 L CYS 215 1_555 ? ? ? ? ? ? ? 2.004 ? ? disulf8 disulf ? ? C CYS 23 SG ? ? ? 1_555 C CYS 88 SG ? ? L CYS 23 L CYS 88 1_555 ? ? ? ? ? ? ? 2.030 ? ? disulf9 disulf ? ? C CYS 135 SG ? ? ? 1_555 C CYS 195 SG ? ? L CYS 135 L CYS 195 1_555 ? ? ? ? ? ? ? 2.029 ? ? disulf10 disulf ? ? D CYS 4 SG ? ? ? 1_555 D CYS 29 SG ? ? A CYS 336 A CYS 361 1_555 ? ? ? ? ? ? ? 2.031 ? ? disulf11 disulf ? ? D CYS 47 SG ? ? ? 1_555 D CYS 100 SG ? ? A CYS 379 A CYS 432 1_555 ? ? ? ? ? ? ? 2.030 ? ? disulf12 disulf ? ? D CYS 59 SG ? ? ? 1_555 D CYS 193 SG ? ? A CYS 391 A CYS 525 1_555 ? ? ? ? ? ? ? 2.033 ? ? disulf13 disulf ? ? D CYS 148 SG ? ? ? 1_555 D CYS 156 SG ? ? A CYS 480 A CYS 488 1_555 ? ? ? ? ? ? ? 2.031 ? ? disulf14 disulf ? ? E CYS 22 SG ? ? ? 1_555 E CYS 96 SG ? ? B CYS 22 B CYS 96 1_555 ? ? ? ? ? ? ? 2.029 ? ? disulf15 disulf ? ? E CYS 148 SG ? ? ? 1_555 E CYS 204 SG ? ? B CYS 148 B CYS 204 1_555 ? ? ? ? ? ? ? 2.031 ? ? disulf16 disulf ? ? E CYS 224 SG ? ? ? 1_555 F CYS 215 SG ? ? B CYS 224 C CYS 215 1_555 ? ? ? ? ? ? ? 2.042 ? ? disulf17 disulf ? ? F CYS 23 SG ? ? ? 1_555 F CYS 88 SG ? ? C CYS 23 C CYS 88 1_555 ? ? ? ? ? ? ? 2.031 ? ? disulf18 disulf ? ? F CYS 135 SG ? ? ? 1_555 F CYS 195 SG ? ? C CYS 135 C CYS 195 1_555 ? ? ? ? ? ? ? 2.030 ? ? disulf19 disulf ? ? G CYS 4 SG ? ? ? 1_555 G CYS 29 SG ? ? D CYS 336 D CYS 361 1_555 ? ? ? ? ? ? ? 2.032 ? ? disulf20 disulf ? ? G CYS 47 SG ? ? ? 1_555 G CYS 100 SG ? ? D CYS 379 D CYS 432 1_555 ? ? ? ? ? ? ? 2.030 ? ? disulf21 disulf ? ? G CYS 59 SG ? ? ? 1_555 G CYS 193 SG ? ? D CYS 391 D CYS 525 1_555 ? ? ? ? ? ? ? 2.033 ? ? disulf22 disulf ? ? G CYS 148 SG ? ? ? 1_555 G CYS 156 SG ? ? D CYS 480 D CYS 488 1_555 ? ? ? ? ? ? ? 2.032 ? ? disulf23 disulf ? ? H CYS 22 SG ? ? ? 1_555 H CYS 96 SG ? ? F CYS 22 F CYS 96 1_555 ? ? ? ? ? ? ? 2.029 ? ? disulf24 disulf ? ? H CYS 148 SG ? ? ? 1_555 H CYS 204 SG ? ? F CYS 148 F CYS 204 1_555 ? ? ? ? ? ? ? 2.031 ? ? disulf25 disulf ? ? H CYS 224 SG ? ? ? 1_555 I CYS 215 SG ? ? F CYS 224 G CYS 215 1_555 ? ? ? ? ? ? ? 2.047 ? ? disulf26 disulf ? ? I CYS 23 SG ? ? ? 1_555 I CYS 88 SG ? ? G CYS 23 G CYS 88 1_555 ? ? ? ? ? ? ? 2.031 ? ? disulf27 disulf ? ? I CYS 135 SG ? ? ? 1_555 I CYS 195 SG ? ? G CYS 135 G CYS 195 1_555 ? ? ? ? ? ? ? 2.029 ? ? covale1 covale one ? A ASN 11 ND2 ? ? ? 1_555 J NAG . C1 ? ? E ASN 343 E NAG 601 1_555 ? ? ? ? ? ? ? 1.439 ? N-Glycosylation covale2 covale one ? D ASN 11 ND2 ? ? ? 1_555 K NAG . C1 ? ? A ASN 343 A NAG 601 1_555 ? ? ? ? ? ? ? 1.439 ? N-Glycosylation covale3 covale one ? G ASN 11 ND2 ? ? ? 1_555 L NAG . C1 ? ? D ASN 343 D NAG 601 1_555 ? ? ? ? ? ? ? 1.439 ? N-Glycosylation # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? covale ? ? # loop_ _pdbx_modification_feature.ordinal _pdbx_modification_feature.label_comp_id _pdbx_modification_feature.label_asym_id _pdbx_modification_feature.label_seq_id _pdbx_modification_feature.label_alt_id _pdbx_modification_feature.modified_residue_label_comp_id _pdbx_modification_feature.modified_residue_label_asym_id _pdbx_modification_feature.modified_residue_label_seq_id _pdbx_modification_feature.modified_residue_label_alt_id _pdbx_modification_feature.auth_comp_id _pdbx_modification_feature.auth_asym_id _pdbx_modification_feature.auth_seq_id _pdbx_modification_feature.PDB_ins_code _pdbx_modification_feature.symmetry _pdbx_modification_feature.modified_residue_auth_comp_id _pdbx_modification_feature.modified_residue_auth_asym_id _pdbx_modification_feature.modified_residue_auth_seq_id _pdbx_modification_feature.modified_residue_PDB_ins_code _pdbx_modification_feature.modified_residue_symmetry _pdbx_modification_feature.comp_id_linking_atom _pdbx_modification_feature.modified_residue_id_linking_atom _pdbx_modification_feature.modified_residue_id _pdbx_modification_feature.ref_pcm_id _pdbx_modification_feature.ref_comp_id _pdbx_modification_feature.type _pdbx_modification_feature.category 1 NAG J . ? ASN A 11 ? NAG E 601 ? 1_555 ASN E 343 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate 2 NAG K . ? ASN D 11 ? NAG A 601 ? 1_555 ASN A 343 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate 3 NAG L . ? ASN G 11 ? NAG D 601 ? 1_555 ASN D 343 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate 4 CYS A 4 ? CYS A 29 ? CYS E 336 ? 1_555 CYS E 361 ? 1_555 SG SG . . . None 'Disulfide bridge' 5 CYS A 47 ? CYS A 100 ? CYS E 379 ? 1_555 CYS E 432 ? 1_555 SG SG . . . None 'Disulfide bridge' 6 CYS A 59 ? CYS A 193 ? CYS E 391 ? 1_555 CYS E 525 ? 1_555 SG SG . . . None 'Disulfide bridge' 7 CYS A 148 ? CYS A 156 ? CYS E 480 ? 1_555 CYS E 488 ? 1_555 SG SG . . . None 'Disulfide bridge' 8 CYS B 22 ? CYS B 96 ? CYS H 22 ? 1_555 CYS H 96 ? 1_555 SG SG . . . None 'Disulfide bridge' 9 CYS B 148 ? CYS B 204 ? CYS H 148 ? 1_555 CYS H 204 ? 1_555 SG SG . . . None 'Disulfide bridge' 10 CYS B 224 ? CYS C 215 ? CYS H 224 ? 1_555 CYS L 215 ? 1_555 SG SG . . . None 'Disulfide bridge' 11 CYS C 23 ? CYS C 88 ? CYS L 23 ? 1_555 CYS L 88 ? 1_555 SG SG . . . None 'Disulfide bridge' 12 CYS C 135 ? CYS C 195 ? CYS L 135 ? 1_555 CYS L 195 ? 1_555 SG SG . . . None 'Disulfide bridge' 13 CYS D 4 ? CYS D 29 ? CYS A 336 ? 1_555 CYS A 361 ? 1_555 SG SG . . . None 'Disulfide bridge' 14 CYS D 47 ? CYS D 100 ? CYS A 379 ? 1_555 CYS A 432 ? 1_555 SG SG . . . None 'Disulfide bridge' 15 CYS D 59 ? CYS D 193 ? CYS A 391 ? 1_555 CYS A 525 ? 1_555 SG SG . . . None 'Disulfide bridge' 16 CYS D 148 ? CYS D 156 ? CYS A 480 ? 1_555 CYS A 488 ? 1_555 SG SG . . . None 'Disulfide bridge' 17 CYS E 22 ? CYS E 96 ? CYS B 22 ? 1_555 CYS B 96 ? 1_555 SG SG . . . None 'Disulfide bridge' 18 CYS E 148 ? CYS E 204 ? CYS B 148 ? 1_555 CYS B 204 ? 1_555 SG SG . . . None 'Disulfide bridge' 19 CYS E 224 ? CYS F 215 ? CYS B 224 ? 1_555 CYS C 215 ? 1_555 SG SG . . . None 'Disulfide bridge' 20 CYS F 23 ? CYS F 88 ? CYS C 23 ? 1_555 CYS C 88 ? 1_555 SG SG . . . None 'Disulfide bridge' 21 CYS F 135 ? CYS F 195 ? CYS C 135 ? 1_555 CYS C 195 ? 1_555 SG SG . . . None 'Disulfide bridge' 22 CYS G 4 ? CYS G 29 ? CYS D 336 ? 1_555 CYS D 361 ? 1_555 SG SG . . . None 'Disulfide bridge' 23 CYS G 47 ? CYS G 100 ? CYS D 379 ? 1_555 CYS D 432 ? 1_555 SG SG . . . None 'Disulfide bridge' 24 CYS G 59 ? CYS G 193 ? CYS D 391 ? 1_555 CYS D 525 ? 1_555 SG SG . . . None 'Disulfide bridge' 25 CYS G 148 ? CYS G 156 ? CYS D 480 ? 1_555 CYS D 488 ? 1_555 SG SG . . . None 'Disulfide bridge' 26 CYS H 22 ? CYS H 96 ? CYS F 22 ? 1_555 CYS F 96 ? 1_555 SG SG . . . None 'Disulfide bridge' 27 CYS H 148 ? CYS H 204 ? CYS F 148 ? 1_555 CYS F 204 ? 1_555 SG SG . . . None 'Disulfide bridge' 28 CYS H 224 ? CYS I 215 ? CYS F 224 ? 1_555 CYS G 215 ? 1_555 SG SG . . . None 'Disulfide bridge' 29 CYS I 23 ? CYS I 88 ? CYS G 23 ? 1_555 CYS G 88 ? 1_555 SG SG . . . None 'Disulfide bridge' 30 CYS I 135 ? CYS I 195 ? CYS G 135 ? 1_555 CYS G 195 ? 1_555 SG SG . . . None 'Disulfide bridge' # loop_ _struct_mon_prot_cis.pdbx_id _struct_mon_prot_cis.label_comp_id _struct_mon_prot_cis.label_seq_id _struct_mon_prot_cis.label_asym_id _struct_mon_prot_cis.label_alt_id _struct_mon_prot_cis.pdbx_PDB_ins_code _struct_mon_prot_cis.auth_comp_id _struct_mon_prot_cis.auth_seq_id _struct_mon_prot_cis.auth_asym_id _struct_mon_prot_cis.pdbx_label_comp_id_2 _struct_mon_prot_cis.pdbx_label_seq_id_2 _struct_mon_prot_cis.pdbx_label_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_ins_code_2 _struct_mon_prot_cis.pdbx_auth_comp_id_2 _struct_mon_prot_cis.pdbx_auth_seq_id_2 _struct_mon_prot_cis.pdbx_auth_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_model_num _struct_mon_prot_cis.pdbx_omega_angle 1 PHE 154 B . ? PHE 154 H PRO 155 B ? PRO 155 H 1 -9.93 2 GLU 156 B . ? GLU 156 H PRO 157 B ? PRO 157 H 1 -6.55 3 SER 7 C . ? SER 7 L PRO 8 C ? PRO 8 L 1 -5.62 4 TYR 141 C . ? TYR 141 L PRO 142 C ? PRO 142 L 1 -2.55 5 PHE 154 E . ? PHE 154 B PRO 155 E ? PRO 155 B 1 -9.92 6 GLU 156 E . ? GLU 156 B PRO 157 E ? PRO 157 B 1 -6.56 7 SER 7 F . ? SER 7 C PRO 8 F ? PRO 8 C 1 -5.68 8 TYR 141 F . ? TYR 141 C PRO 142 F ? PRO 142 C 1 -2.62 9 PHE 154 H . ? PHE 154 F PRO 155 H ? PRO 155 F 1 -9.79 10 GLU 156 H . ? GLU 156 F PRO 157 H ? PRO 157 F 1 -6.58 11 SER 7 I . ? SER 7 G PRO 8 I ? PRO 8 G 1 -5.64 12 TYR 141 I . ? TYR 141 G PRO 142 I ? PRO 142 G 1 -2.50 # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details AA1 ? 5 ? AA2 ? 2 ? AA3 ? 2 ? AA4 ? 5 ? AA5 ? 2 ? AA6 ? 4 ? AA7 ? 6 ? AA8 ? 4 ? AA9 ? 4 ? AB1 ? 3 ? AB2 ? 3 ? AB3 ? 6 ? AB4 ? 4 ? AB5 ? 4 ? AB6 ? 5 ? AB7 ? 5 ? AB8 ? 2 ? AB9 ? 2 ? AC1 ? 2 ? AC2 ? 4 ? AC3 ? 6 ? AC4 ? 4 ? AC5 ? 4 ? AC6 ? 3 ? AC7 ? 3 ? AC8 ? 6 ? AC9 ? 4 ? AD1 ? 4 ? AD2 ? 5 ? AD3 ? 5 ? AD4 ? 2 ? AD5 ? 2 ? AD6 ? 2 ? AD7 ? 4 ? AD8 ? 6 ? AD9 ? 4 ? AE1 ? 4 ? AE2 ? 3 ? AE3 ? 3 ? AE4 ? 6 ? AE5 ? 4 ? AE6 ? 4 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense AA1 1 2 ? anti-parallel AA1 2 3 ? anti-parallel AA1 3 4 ? anti-parallel AA1 4 5 ? anti-parallel AA2 1 2 ? parallel AA3 1 2 ? anti-parallel AA4 1 2 ? parallel AA4 2 3 ? anti-parallel AA4 3 4 ? anti-parallel AA4 4 5 ? anti-parallel AA5 1 2 ? anti-parallel AA6 1 2 ? anti-parallel AA6 2 3 ? anti-parallel AA6 3 4 ? anti-parallel AA7 1 2 ? parallel AA7 2 3 ? anti-parallel AA7 3 4 ? anti-parallel AA7 4 5 ? anti-parallel AA7 5 6 ? anti-parallel AA8 1 2 ? anti-parallel AA8 2 3 ? anti-parallel AA8 3 4 ? anti-parallel AA9 1 2 ? anti-parallel AA9 2 3 ? anti-parallel AA9 3 4 ? anti-parallel AB1 1 2 ? anti-parallel AB1 2 3 ? anti-parallel AB2 1 2 ? anti-parallel AB2 2 3 ? anti-parallel AB3 1 2 ? parallel AB3 2 3 ? anti-parallel AB3 3 4 ? anti-parallel AB3 4 5 ? anti-parallel AB3 5 6 ? anti-parallel AB4 1 2 ? parallel AB4 2 3 ? anti-parallel AB4 3 4 ? anti-parallel AB5 1 2 ? anti-parallel AB5 2 3 ? anti-parallel AB5 3 4 ? anti-parallel AB6 1 2 ? anti-parallel AB6 2 3 ? anti-parallel AB6 3 4 ? anti-parallel AB6 4 5 ? parallel AB7 1 2 ? anti-parallel AB7 2 3 ? anti-parallel AB7 3 4 ? anti-parallel AB7 4 5 ? anti-parallel AB8 1 2 ? parallel AB9 1 2 ? anti-parallel AC1 1 2 ? anti-parallel AC2 1 2 ? anti-parallel AC2 2 3 ? anti-parallel AC2 3 4 ? anti-parallel AC3 1 2 ? parallel AC3 2 3 ? anti-parallel AC3 3 4 ? anti-parallel AC3 4 5 ? anti-parallel AC3 5 6 ? anti-parallel AC4 1 2 ? anti-parallel AC4 2 3 ? anti-parallel AC4 3 4 ? anti-parallel AC5 1 2 ? anti-parallel AC5 2 3 ? anti-parallel AC5 3 4 ? anti-parallel AC6 1 2 ? anti-parallel AC6 2 3 ? anti-parallel AC7 1 2 ? anti-parallel AC7 2 3 ? anti-parallel AC8 1 2 ? parallel AC8 2 3 ? anti-parallel AC8 3 4 ? anti-parallel AC8 4 5 ? anti-parallel AC8 5 6 ? anti-parallel AC9 1 2 ? parallel AC9 2 3 ? anti-parallel AC9 3 4 ? anti-parallel AD1 1 2 ? anti-parallel AD1 2 3 ? anti-parallel AD1 3 4 ? anti-parallel AD2 1 2 ? anti-parallel AD2 2 3 ? anti-parallel AD2 3 4 ? anti-parallel AD2 4 5 ? parallel AD3 1 2 ? anti-parallel AD3 2 3 ? anti-parallel AD3 3 4 ? anti-parallel AD3 4 5 ? anti-parallel AD4 1 2 ? parallel AD5 1 2 ? anti-parallel AD6 1 2 ? anti-parallel AD7 1 2 ? anti-parallel AD7 2 3 ? anti-parallel AD7 3 4 ? anti-parallel AD8 1 2 ? parallel AD8 2 3 ? anti-parallel AD8 3 4 ? anti-parallel AD8 4 5 ? anti-parallel AD8 5 6 ? anti-parallel AD9 1 2 ? anti-parallel AD9 2 3 ? anti-parallel AD9 3 4 ? anti-parallel AE1 1 2 ? anti-parallel AE1 2 3 ? anti-parallel AE1 3 4 ? anti-parallel AE2 1 2 ? anti-parallel AE2 2 3 ? anti-parallel AE3 1 2 ? anti-parallel AE3 2 3 ? anti-parallel AE4 1 2 ? parallel AE4 2 3 ? anti-parallel AE4 3 4 ? anti-parallel AE4 4 5 ? anti-parallel AE4 5 6 ? anti-parallel AE5 1 2 ? parallel AE5 2 3 ? anti-parallel AE5 3 4 ? anti-parallel AE6 1 2 ? anti-parallel AE6 2 3 ? anti-parallel AE6 3 4 ? anti-parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id AA1 1 ASN A 22 ? ILE A 26 ? ASN E 354 ILE E 358 AA1 2 ASN A 62 ? ARG A 71 ? ASN E 394 ARG E 403 AA1 3 PRO A 175 ? GLU A 184 ? PRO E 507 GLU E 516 AA1 4 GLY A 99 ? ASN A 105 ? GLY E 431 ASN E 437 AA1 5 THR A 44 ? TYR A 48 ? THR E 376 TYR E 380 AA2 1 CYS A 29 ? VAL A 30 ? CYS E 361 VAL E 362 AA2 2 VAL A 192 ? CYS A 193 ? VAL E 524 CYS E 525 AA3 1 LEU A 120 ? ARG A 122 ? LEU E 452 ARG E 454 AA3 2 LEU A 160 ? SER A 162 ? LEU E 492 SER E 494 AA4 1 GLU A 133 ? ASP A 135 ? GLU E 465 ASP E 467 AA4 2 LEU I 155 ? SER I 157 ? LEU G 155 SER G 157 AA4 3 ALA I 145 ? VAL I 151 ? ALA G 145 VAL G 151 AA4 4 VAL I 192 ? HIS I 199 ? VAL G 192 HIS G 199 AA4 5 VAL I 206 ? ASN I 211 ? VAL G 206 ASN G 211 AA5 1 TYR A 141 ? GLN A 142 ? TYR E 473 GLN E 474 AA5 2 CYS A 156 ? TYR A 157 ? CYS E 488 TYR E 489 AA6 1 GLN B 3 ? SER B 7 ? GLN H 3 SER H 7 AA6 2 LEU B 18 ? SER B 25 ? LEU H 18 SER H 25 AA6 3 THR B 78 ? MET B 83 ? THR H 78 MET H 83 AA6 4 PHE B 68 ? ASP B 73 ? PHE H 68 ASP H 73 AA7 1 VAL B 11 ? VAL B 12 ? VAL H 11 VAL H 12 AA7 2 THR B 115 ? VAL B 119 ? THR H 115 VAL H 119 AA7 3 ALA B 92 ? LYS B 98 ? ALA H 92 LYS H 98 AA7 4 MET B 34 ? GLN B 39 ? MET H 34 GLN H 39 AA7 5 LEU B 45 ? ILE B 51 ? LEU H 45 ILE H 51 AA7 6 LYS B 58 ? TYR B 60 ? LYS H 58 TYR H 60 AA8 1 SER B 128 ? LEU B 132 ? SER H 128 LEU H 132 AA8 2 ALA B 144 ? TYR B 153 ? ALA H 144 TYR H 153 AA8 3 TYR B 184 ? VAL B 192 ? TYR H 184 VAL H 192 AA8 4 VAL B 171 ? THR B 173 ? VAL H 171 THR H 173 AA9 1 SER B 128 ? LEU B 132 ? SER H 128 LEU H 132 AA9 2 ALA B 144 ? TYR B 153 ? ALA H 144 TYR H 153 AA9 3 TYR B 184 ? VAL B 192 ? TYR H 184 VAL H 192 AA9 4 VAL B 177 ? LEU B 178 ? VAL H 177 LEU H 178 AB1 1 THR B 159 ? TRP B 162 ? THR H 159 TRP H 162 AB1 2 TYR B 202 ? HIS B 208 ? TYR H 202 HIS H 208 AB1 3 THR B 213 ? VAL B 219 ? THR H 213 VAL H 219 AB2 1 MET C 4 ? SER C 7 ? MET L 4 SER L 7 AB2 2 VAL C 19 ? ILE C 29 ? VAL L 19 ILE L 29 AB2 3 PHE C 62 ? ILE C 75 ? PHE L 62 ILE L 75 AB3 1 SER C 10 ? ALA C 13 ? SER L 10 ALA L 13 AB3 2 THR C 103 ? ILE C 107 ? THR L 103 ILE L 107 AB3 3 THR C 85 ? GLN C 90 ? THR L 85 GLN L 90 AB3 4 LEU C 33 ? GLN C 38 ? LEU L 33 GLN L 38 AB3 5 LYS C 45 ? TYR C 49 ? LYS L 45 TYR L 49 AB3 6 SER C 53 ? LEU C 54 ? SER L 53 LEU L 54 AB4 1 SER C 10 ? ALA C 13 ? SER L 10 ALA L 13 AB4 2 THR C 103 ? ILE C 107 ? THR L 103 ILE L 107 AB4 3 THR C 85 ? GLN C 90 ? THR L 85 GLN L 90 AB4 4 THR C 98 ? PHE C 99 ? THR L 98 PHE L 99 AB5 1 SER C 115 ? PHE C 119 ? SER L 115 PHE L 119 AB5 2 THR C 130 ? PHE C 140 ? THR L 130 PHE L 140 AB5 3 TYR C 174 ? SER C 183 ? TYR L 174 SER L 183 AB5 4 SER C 160 ? VAL C 164 ? SER L 160 VAL L 164 AB6 1 VAL C 206 ? ASN C 211 ? VAL L 206 ASN L 211 AB6 2 VAL C 192 ? HIS C 199 ? VAL L 192 HIS L 199 AB6 3 ALA C 145 ? VAL C 151 ? ALA L 145 VAL L 151 AB6 4 LEU C 155 ? SER C 157 ? LEU L 155 SER L 157 AB6 5 GLU D 133 ? ASP D 135 ? GLU A 465 ASP A 467 AB7 1 ASN D 22 ? ILE D 26 ? ASN A 354 ILE A 358 AB7 2 ASN D 62 ? ARG D 71 ? ASN A 394 ARG A 403 AB7 3 PRO D 175 ? GLU D 184 ? PRO A 507 GLU A 516 AB7 4 GLY D 99 ? ASN D 105 ? GLY A 431 ASN A 437 AB7 5 THR D 44 ? TYR D 48 ? THR A 376 TYR A 380 AB8 1 CYS D 29 ? VAL D 30 ? CYS A 361 VAL A 362 AB8 2 VAL D 192 ? CYS D 193 ? VAL A 524 CYS A 525 AB9 1 LEU D 120 ? ARG D 122 ? LEU A 452 ARG A 454 AB9 2 LEU D 160 ? SER D 162 ? LEU A 492 SER A 494 AC1 1 TYR D 141 ? GLN D 142 ? TYR A 473 GLN A 474 AC1 2 CYS D 156 ? TYR D 157 ? CYS A 488 TYR A 489 AC2 1 GLN E 3 ? SER E 7 ? GLN B 3 SER B 7 AC2 2 LEU E 18 ? SER E 25 ? LEU B 18 SER B 25 AC2 3 THR E 78 ? MET E 83 ? THR B 78 MET B 83 AC2 4 PHE E 68 ? ASP E 73 ? PHE B 68 ASP B 73 AC3 1 VAL E 11 ? VAL E 12 ? VAL B 11 VAL B 12 AC3 2 THR E 115 ? VAL E 119 ? THR B 115 VAL B 119 AC3 3 ALA E 92 ? LYS E 98 ? ALA B 92 LYS B 98 AC3 4 MET E 34 ? GLN E 39 ? MET B 34 GLN B 39 AC3 5 LEU E 45 ? ILE E 51 ? LEU B 45 ILE B 51 AC3 6 LYS E 58 ? TYR E 60 ? LYS B 58 TYR B 60 AC4 1 SER E 128 ? LEU E 132 ? SER B 128 LEU B 132 AC4 2 ALA E 144 ? TYR E 153 ? ALA B 144 TYR B 153 AC4 3 TYR E 184 ? VAL E 192 ? TYR B 184 VAL B 192 AC4 4 VAL E 171 ? THR E 173 ? VAL B 171 THR B 173 AC5 1 SER E 128 ? LEU E 132 ? SER B 128 LEU B 132 AC5 2 ALA E 144 ? TYR E 153 ? ALA B 144 TYR B 153 AC5 3 TYR E 184 ? VAL E 192 ? TYR B 184 VAL B 192 AC5 4 VAL E 177 ? LEU E 178 ? VAL B 177 LEU B 178 AC6 1 THR E 159 ? TRP E 162 ? THR B 159 TRP B 162 AC6 2 TYR E 202 ? HIS E 208 ? TYR B 202 HIS B 208 AC6 3 THR E 213 ? VAL E 219 ? THR B 213 VAL B 219 AC7 1 MET F 4 ? SER F 7 ? MET C 4 SER C 7 AC7 2 VAL F 19 ? ILE F 29 ? VAL C 19 ILE C 29 AC7 3 PHE F 62 ? ILE F 75 ? PHE C 62 ILE C 75 AC8 1 SER F 10 ? ALA F 13 ? SER C 10 ALA C 13 AC8 2 THR F 103 ? ILE F 107 ? THR C 103 ILE C 107 AC8 3 THR F 85 ? GLN F 90 ? THR C 85 GLN C 90 AC8 4 LEU F 33 ? GLN F 38 ? LEU C 33 GLN C 38 AC8 5 LYS F 45 ? TYR F 49 ? LYS C 45 TYR C 49 AC8 6 SER F 53 ? LEU F 54 ? SER C 53 LEU C 54 AC9 1 SER F 10 ? ALA F 13 ? SER C 10 ALA C 13 AC9 2 THR F 103 ? ILE F 107 ? THR C 103 ILE C 107 AC9 3 THR F 85 ? GLN F 90 ? THR C 85 GLN C 90 AC9 4 THR F 98 ? PHE F 99 ? THR C 98 PHE C 99 AD1 1 SER F 115 ? PHE F 119 ? SER C 115 PHE C 119 AD1 2 THR F 130 ? PHE F 140 ? THR C 130 PHE C 140 AD1 3 TYR F 174 ? SER F 183 ? TYR C 174 SER C 183 AD1 4 SER F 160 ? VAL F 164 ? SER C 160 VAL C 164 AD2 1 VAL F 206 ? ASN F 211 ? VAL C 206 ASN C 211 AD2 2 VAL F 192 ? HIS F 199 ? VAL C 192 HIS C 199 AD2 3 ALA F 145 ? VAL F 151 ? ALA C 145 VAL C 151 AD2 4 LEU F 155 ? GLN F 156 ? LEU C 155 GLN C 156 AD2 5 GLU G 133 ? ARG G 134 ? GLU D 465 ARG D 466 AD3 1 ASN G 22 ? ILE G 26 ? ASN D 354 ILE D 358 AD3 2 ASN G 62 ? ARG G 71 ? ASN D 394 ARG D 403 AD3 3 PRO G 175 ? GLU G 184 ? PRO D 507 GLU D 516 AD3 4 GLY G 99 ? ASN G 105 ? GLY D 431 ASN D 437 AD3 5 THR G 44 ? TYR G 48 ? THR D 376 TYR D 380 AD4 1 CYS G 29 ? VAL G 30 ? CYS D 361 VAL D 362 AD4 2 VAL G 192 ? CYS G 193 ? VAL D 524 CYS D 525 AD5 1 LEU G 120 ? ARG G 122 ? LEU D 452 ARG D 454 AD5 2 LEU G 160 ? SER G 162 ? LEU D 492 SER D 494 AD6 1 TYR G 141 ? GLN G 142 ? TYR D 473 GLN D 474 AD6 2 CYS G 156 ? TYR G 157 ? CYS D 488 TYR D 489 AD7 1 GLN H 3 ? SER H 7 ? GLN F 3 SER F 7 AD7 2 LEU H 18 ? SER H 25 ? LEU F 18 SER F 25 AD7 3 THR H 78 ? MET H 83 ? THR F 78 MET F 83 AD7 4 PHE H 68 ? ASP H 73 ? PHE F 68 ASP F 73 AD8 1 VAL H 11 ? VAL H 12 ? VAL F 11 VAL F 12 AD8 2 THR H 115 ? VAL H 119 ? THR F 115 VAL F 119 AD8 3 ALA H 92 ? LYS H 98 ? ALA F 92 LYS F 98 AD8 4 MET H 34 ? GLN H 39 ? MET F 34 GLN F 39 AD8 5 LEU H 45 ? ILE H 51 ? LEU F 45 ILE F 51 AD8 6 LYS H 58 ? TYR H 60 ? LYS F 58 TYR F 60 AD9 1 SER H 128 ? LEU H 132 ? SER F 128 LEU F 132 AD9 2 ALA H 144 ? TYR H 153 ? ALA F 144 TYR F 153 AD9 3 TYR H 184 ? VAL H 192 ? TYR F 184 VAL F 192 AD9 4 VAL H 171 ? THR H 173 ? VAL F 171 THR F 173 AE1 1 SER H 128 ? LEU H 132 ? SER F 128 LEU F 132 AE1 2 ALA H 144 ? TYR H 153 ? ALA F 144 TYR F 153 AE1 3 TYR H 184 ? VAL H 192 ? TYR F 184 VAL F 192 AE1 4 VAL H 177 ? LEU H 178 ? VAL F 177 LEU F 178 AE2 1 THR H 159 ? TRP H 162 ? THR F 159 TRP F 162 AE2 2 TYR H 202 ? HIS H 208 ? TYR F 202 HIS F 208 AE2 3 THR H 213 ? VAL H 219 ? THR F 213 VAL F 219 AE3 1 MET I 4 ? SER I 7 ? MET G 4 SER G 7 AE3 2 VAL I 19 ? ILE I 29 ? VAL G 19 ILE G 29 AE3 3 PHE I 62 ? ILE I 75 ? PHE G 62 ILE G 75 AE4 1 SER I 10 ? ALA I 13 ? SER G 10 ALA G 13 AE4 2 THR I 103 ? ILE I 107 ? THR G 103 ILE G 107 AE4 3 THR I 85 ? GLN I 90 ? THR G 85 GLN G 90 AE4 4 LEU I 33 ? GLN I 38 ? LEU G 33 GLN G 38 AE4 5 LYS I 45 ? TYR I 49 ? LYS G 45 TYR G 49 AE4 6 SER I 53 ? LEU I 54 ? SER G 53 LEU G 54 AE5 1 SER I 10 ? ALA I 13 ? SER G 10 ALA G 13 AE5 2 THR I 103 ? ILE I 107 ? THR G 103 ILE G 107 AE5 3 THR I 85 ? GLN I 90 ? THR G 85 GLN G 90 AE5 4 THR I 98 ? PHE I 99 ? THR G 98 PHE G 99 AE6 1 SER I 115 ? PHE I 119 ? SER G 115 PHE G 119 AE6 2 THR I 130 ? PHE I 140 ? THR G 130 PHE G 140 AE6 3 TYR I 174 ? SER I 183 ? TYR G 174 SER G 183 AE6 4 SER I 160 ? VAL I 164 ? SER G 160 VAL G 164 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id AA1 1 2 N ILE A 26 ? N ILE E 358 O VAL A 63 ? O VAL E 395 AA1 2 3 N PHE A 68 ? N PHE E 400 O VAL A 178 ? O VAL E 510 AA1 3 4 O ARG A 177 ? O ARG E 509 N TRP A 104 ? N TRP E 436 AA1 4 5 O GLY A 99 ? O GLY E 431 N TYR A 48 ? N TYR E 380 AA2 1 2 N CYS A 29 ? N CYS E 361 O CYS A 193 ? O CYS E 525 AA3 1 2 N TYR A 121 ? N TYR E 453 O GLN A 161 ? O GLN E 493 AA4 1 2 N ARG A 134 ? N ARG E 466 O LEU I 155 ? O LEU G 155 AA4 2 3 O GLN I 156 ? O GLN G 156 N TRP I 149 ? N TRP G 149 AA4 3 4 N LYS I 150 ? N LYS G 150 O ALA I 194 ? O ALA G 194 AA4 4 5 N VAL I 197 ? N VAL G 197 O VAL I 206 ? O VAL G 206 AA5 1 2 N TYR A 141 ? N TYR E 473 O TYR A 157 ? O TYR E 489 AA6 1 2 N SER B 7 ? N SER H 7 O SER B 21 ? O SER H 21 AA6 2 3 N LEU B 18 ? N LEU H 18 O MET B 83 ? O MET H 83 AA6 3 4 O TYR B 80 ? O TYR H 80 N SER B 71 ? N SER H 71 AA7 1 2 N VAL B 12 ? N VAL H 12 O THR B 118 ? O THR H 118 AA7 2 3 O THR B 115 ? O THR H 115 N TYR B 94 ? N TYR H 94 AA7 3 4 O TYR B 95 ? O TYR H 95 N VAL B 37 ? N VAL H 37 AA7 4 5 N MET B 34 ? N MET H 34 O ILE B 51 ? O ILE H 51 AA7 5 6 N VAL B 50 ? N VAL H 50 O TYR B 59 ? O TYR H 59 AA8 1 2 N SER B 128 ? N SER H 128 O LYS B 151 ? O LYS H 151 AA8 2 3 N VAL B 150 ? N VAL H 150 O LEU B 186 ? O LEU H 186 AA8 3 4 O VAL B 189 ? O VAL H 189 N HIS B 172 ? N HIS H 172 AA9 1 2 N SER B 128 ? N SER H 128 O LYS B 151 ? O LYS H 151 AA9 2 3 N VAL B 150 ? N VAL H 150 O LEU B 186 ? O LEU H 186 AA9 3 4 O SER B 185 ? O SER H 185 N VAL B 177 ? N VAL H 177 AB1 1 2 N THR B 159 ? N THR H 159 O ASN B 207 ? O ASN H 207 AB1 2 3 N HIS B 208 ? N HIS H 208 O THR B 213 ? O THR H 213 AB2 1 2 N SER C 7 ? N SER L 7 O THR C 22 ? O THR L 22 AB2 2 3 N ILE C 29 ? N ILE L 29 O GLY C 68 ? O GLY L 68 AB3 1 2 N ALA C 13 ? N ALA L 13 O GLU C 106 ? O GLU L 106 AB3 2 3 O THR C 103 ? O THR L 103 N TYR C 86 ? N TYR L 86 AB3 3 4 O TYR C 87 ? O TYR L 87 N TYR C 36 ? N TYR L 36 AB3 4 5 N GLN C 37 ? N GLN L 37 O LYS C 45 ? O LYS L 45 AB3 5 6 N TYR C 49 ? N TYR L 49 O SER C 53 ? O SER L 53 AB4 1 2 N ALA C 13 ? N ALA L 13 O GLU C 106 ? O GLU L 106 AB4 2 3 O THR C 103 ? O THR L 103 N TYR C 86 ? N TYR L 86 AB4 3 4 N GLN C 90 ? N GLN L 90 O THR C 98 ? O THR L 98 AB5 1 2 N SER C 115 ? N SER L 115 O ASN C 138 ? O ASN L 138 AB5 2 3 N LEU C 137 ? N LEU L 137 O LEU C 176 ? O LEU L 176 AB5 3 4 O THR C 179 ? O THR L 179 N GLN C 161 ? N GLN L 161 AB6 1 2 O VAL C 206 ? O VAL L 206 N VAL C 197 ? N VAL L 197 AB6 2 3 O ALA C 194 ? O ALA L 194 N LYS C 150 ? N LYS L 150 AB6 3 4 N TRP C 149 ? N TRP L 149 O GLN C 156 ? O GLN L 156 AB6 4 5 N LEU C 155 ? N LEU L 155 O ARG D 134 ? O ARG A 466 AB7 1 2 N ILE D 26 ? N ILE A 358 O VAL D 63 ? O VAL A 395 AB7 2 3 N PHE D 68 ? N PHE A 400 O VAL D 178 ? O VAL A 510 AB7 3 4 O ARG D 177 ? O ARG A 509 N TRP D 104 ? N TRP A 436 AB7 4 5 O GLY D 99 ? O GLY A 431 N TYR D 48 ? N TYR A 380 AB8 1 2 N CYS D 29 ? N CYS A 361 O CYS D 193 ? O CYS A 525 AB9 1 2 N TYR D 121 ? N TYR A 453 O GLN D 161 ? O GLN A 493 AC1 1 2 N TYR D 141 ? N TYR A 473 O TYR D 157 ? O TYR A 489 AC2 1 2 N SER E 7 ? N SER B 7 O SER E 21 ? O SER B 21 AC2 2 3 N LEU E 18 ? N LEU B 18 O MET E 83 ? O MET B 83 AC2 3 4 O TYR E 80 ? O TYR B 80 N SER E 71 ? N SER B 71 AC3 1 2 N VAL E 12 ? N VAL B 12 O THR E 118 ? O THR B 118 AC3 2 3 O THR E 115 ? O THR B 115 N TYR E 94 ? N TYR B 94 AC3 3 4 O TYR E 95 ? O TYR B 95 N VAL E 37 ? N VAL B 37 AC3 4 5 N MET E 34 ? N MET B 34 O ILE E 51 ? O ILE B 51 AC3 5 6 N VAL E 50 ? N VAL B 50 O TYR E 59 ? O TYR B 59 AC4 1 2 N SER E 128 ? N SER B 128 O LYS E 151 ? O LYS B 151 AC4 2 3 N VAL E 150 ? N VAL B 150 O LEU E 186 ? O LEU B 186 AC4 3 4 O VAL E 189 ? O VAL B 189 N HIS E 172 ? N HIS B 172 AC5 1 2 N SER E 128 ? N SER B 128 O LYS E 151 ? O LYS B 151 AC5 2 3 N VAL E 150 ? N VAL B 150 O LEU E 186 ? O LEU B 186 AC5 3 4 O SER E 185 ? O SER B 185 N VAL E 177 ? N VAL B 177 AC6 1 2 N THR E 159 ? N THR B 159 O ASN E 207 ? O ASN B 207 AC6 2 3 N HIS E 208 ? N HIS B 208 O THR E 213 ? O THR B 213 AC7 1 2 N SER F 7 ? N SER C 7 O THR F 22 ? O THR C 22 AC7 2 3 N ILE F 29 ? N ILE C 29 O GLY F 68 ? O GLY C 68 AC8 1 2 N ALA F 13 ? N ALA C 13 O GLU F 106 ? O GLU C 106 AC8 2 3 O THR F 103 ? O THR C 103 N TYR F 86 ? N TYR C 86 AC8 3 4 O TYR F 87 ? O TYR C 87 N TYR F 36 ? N TYR C 36 AC8 4 5 N GLN F 37 ? N GLN C 37 O LYS F 45 ? O LYS C 45 AC8 5 6 N TYR F 49 ? N TYR C 49 O SER F 53 ? O SER C 53 AC9 1 2 N ALA F 13 ? N ALA C 13 O GLU F 106 ? O GLU C 106 AC9 2 3 O THR F 103 ? O THR C 103 N TYR F 86 ? N TYR C 86 AC9 3 4 N GLN F 90 ? N GLN C 90 O THR F 98 ? O THR C 98 AD1 1 2 N SER F 115 ? N SER C 115 O ASN F 138 ? O ASN C 138 AD1 2 3 N LEU F 137 ? N LEU C 137 O LEU F 176 ? O LEU C 176 AD1 3 4 O THR F 179 ? O THR C 179 N GLN F 161 ? N GLN C 161 AD2 1 2 O VAL F 206 ? O VAL C 206 N VAL F 197 ? N VAL C 197 AD2 2 3 O ALA F 194 ? O ALA C 194 N LYS F 150 ? N LYS C 150 AD2 3 4 N TRP F 149 ? N TRP C 149 O GLN F 156 ? O GLN C 156 AD2 4 5 N LEU F 155 ? N LEU C 155 O ARG G 134 ? O ARG D 466 AD3 1 2 N ILE G 26 ? N ILE D 358 O VAL G 63 ? O VAL D 395 AD3 2 3 N PHE G 68 ? N PHE D 400 O VAL G 178 ? O VAL D 510 AD3 3 4 O ARG G 177 ? O ARG D 509 N TRP G 104 ? N TRP D 436 AD3 4 5 O GLY G 99 ? O GLY D 431 N TYR G 48 ? N TYR D 380 AD4 1 2 N CYS G 29 ? N CYS D 361 O CYS G 193 ? O CYS D 525 AD5 1 2 N TYR G 121 ? N TYR D 453 O GLN G 161 ? O GLN D 493 AD6 1 2 N TYR G 141 ? N TYR D 473 O TYR G 157 ? O TYR D 489 AD7 1 2 N SER H 7 ? N SER F 7 O SER H 21 ? O SER F 21 AD7 2 3 N LEU H 18 ? N LEU F 18 O MET H 83 ? O MET F 83 AD7 3 4 O TYR H 80 ? O TYR F 80 N SER H 71 ? N SER F 71 AD8 1 2 N VAL H 12 ? N VAL F 12 O THR H 118 ? O THR F 118 AD8 2 3 O THR H 115 ? O THR F 115 N TYR H 94 ? N TYR F 94 AD8 3 4 O TYR H 95 ? O TYR F 95 N VAL H 37 ? N VAL F 37 AD8 4 5 N MET H 34 ? N MET F 34 O ILE H 51 ? O ILE F 51 AD8 5 6 N VAL H 50 ? N VAL F 50 O TYR H 59 ? O TYR F 59 AD9 1 2 N SER H 128 ? N SER F 128 O LYS H 151 ? O LYS F 151 AD9 2 3 N VAL H 150 ? N VAL F 150 O LEU H 186 ? O LEU F 186 AD9 3 4 O VAL H 189 ? O VAL F 189 N HIS H 172 ? N HIS F 172 AE1 1 2 N SER H 128 ? N SER F 128 O LYS H 151 ? O LYS F 151 AE1 2 3 N VAL H 150 ? N VAL F 150 O LEU H 186 ? O LEU F 186 AE1 3 4 O SER H 185 ? O SER F 185 N VAL H 177 ? N VAL F 177 AE2 1 2 N THR H 159 ? N THR F 159 O ASN H 207 ? O ASN F 207 AE2 2 3 N HIS H 208 ? N HIS F 208 O THR H 213 ? O THR F 213 AE3 1 2 N SER I 7 ? N SER G 7 O THR I 22 ? O THR G 22 AE3 2 3 N ILE I 29 ? N ILE G 29 O GLY I 68 ? O GLY G 68 AE4 1 2 N ALA I 13 ? N ALA G 13 O GLU I 106 ? O GLU G 106 AE4 2 3 O THR I 103 ? O THR G 103 N TYR I 86 ? N TYR G 86 AE4 3 4 O TYR I 87 ? O TYR G 87 N TYR I 36 ? N TYR G 36 AE4 4 5 N GLN I 37 ? N GLN G 37 O LYS I 45 ? O LYS G 45 AE4 5 6 N TYR I 49 ? N TYR G 49 O SER I 53 ? O SER G 53 AE5 1 2 N ALA I 13 ? N ALA G 13 O GLU I 106 ? O GLU G 106 AE5 2 3 O THR I 103 ? O THR G 103 N TYR I 86 ? N TYR G 86 AE5 3 4 N GLN I 90 ? N GLN G 90 O THR I 98 ? O THR G 98 AE6 1 2 N SER I 115 ? N SER G 115 O ASN I 138 ? O ASN G 138 AE6 2 3 N LEU I 137 ? N LEU G 137 O LEU I 176 ? O LEU G 176 AE6 3 4 O THR I 179 ? O THR G 179 N GLN I 161 ? N GLN G 161 # _pdbx_entry_details.entry_id 6ZDG _pdbx_entry_details.has_ligand_of_interest N _pdbx_entry_details.compound_details ? _pdbx_entry_details.source_details ? _pdbx_entry_details.nonpolymer_details ? _pdbx_entry_details.sequence_details ? _pdbx_entry_details.has_protein_modification Y # loop_ _pdbx_validate_close_contact.id _pdbx_validate_close_contact.PDB_model_num _pdbx_validate_close_contact.auth_atom_id_1 _pdbx_validate_close_contact.auth_asym_id_1 _pdbx_validate_close_contact.auth_comp_id_1 _pdbx_validate_close_contact.auth_seq_id_1 _pdbx_validate_close_contact.PDB_ins_code_1 _pdbx_validate_close_contact.label_alt_id_1 _pdbx_validate_close_contact.auth_atom_id_2 _pdbx_validate_close_contact.auth_asym_id_2 _pdbx_validate_close_contact.auth_comp_id_2 _pdbx_validate_close_contact.auth_seq_id_2 _pdbx_validate_close_contact.PDB_ins_code_2 _pdbx_validate_close_contact.label_alt_id_2 _pdbx_validate_close_contact.dist 1 1 HZ2 A LYS 386 ? ? O B LEU 103 ? ? 1.50 2 1 H A ALA 363 ? ? O A CYS 525 ? ? 1.52 3 1 H D ALA 363 ? ? O D CYS 525 ? ? 1.52 4 1 H E ALA 363 ? ? O E CYS 525 ? ? 1.52 5 1 HZ3 D LYS 356 ? ? O D ARG 357 ? ? 1.53 6 1 HZ3 E LYS 356 ? ? O E ARG 357 ? ? 1.54 7 1 H B SER 164 ? ? OD1 B ASN 205 ? ? 1.55 8 1 HZ3 A LYS 356 ? ? O A ARG 357 ? ? 1.55 9 1 H F SER 164 ? ? OD1 F ASN 205 ? ? 1.55 10 1 H H SER 164 ? ? OD1 H ASN 205 ? ? 1.55 11 1 H D GLN 498 ? ? OD1 D ASN 501 ? ? 1.55 12 1 H A GLN 498 ? ? OD1 A ASN 501 ? ? 1.56 13 1 H E GLN 498 ? ? OD1 E ASN 501 ? ? 1.56 14 1 H C GLN 37 ? ? O C LYS 45 ? ? 1.57 15 1 H F ARG 87 ? ? OD2 F ASP 90 ? ? 1.57 16 1 H L GLN 37 ? ? O L LYS 45 ? ? 1.57 17 1 H G GLN 37 ? ? O G LYS 45 ? ? 1.57 18 1 OE1 G GLN 125 ? ? HG G SER 132 ? ? 1.58 19 1 H H ARG 87 ? ? OD2 H ASP 90 ? ? 1.58 20 1 OD1 D ASN 439 ? ? HG D SER 443 ? ? 1.58 21 1 H C ILE 29 ? ? O C GLY 68 ? ? 1.59 22 1 OE1 L GLN 125 ? ? HG L SER 132 ? ? 1.59 23 1 H L ILE 29 ? ? O L GLY 68 ? ? 1.59 24 1 H G ILE 29 ? ? O G GLY 68 ? ? 1.59 25 1 O B VAL 48 ? ? H B ALA 61 ? ? 1.59 26 1 H B ARG 87 ? ? OD2 B ASP 90 ? ? 1.59 27 1 HZ3 E LYS 424 ? ? O E LEU 425 ? ? 1.59 28 1 HZ3 D LYS 424 ? ? O D LEU 425 ? ? 1.59 29 1 HZ3 A LYS 424 ? ? O A LEU 425 ? ? 1.59 30 1 O F VAL 48 ? ? H F ALA 61 ? ? 1.59 31 1 HG H SER 7 ? ? OG H SER 21 ? ? 1.59 32 1 O A ASN 334 ? ? H A VAL 362 ? ? 1.60 33 1 OE1 C GLN 125 ? ? HG C SER 132 ? ? 1.60 34 1 O E ASN 334 ? ? H E VAL 362 ? ? 1.60 35 1 O D ASN 334 ? ? H D VAL 362 ? ? 1.60 36 1 O G GLN 125 ? ? HG G SER 128 ? ? 1.60 37 1 HG F SER 7 ? ? OG F SER 21 ? ? 1.60 38 1 O H VAL 48 ? ? H H ALA 61 ? ? 1.60 39 1 OG B SER 7 ? ? OG B SER 21 ? ? 1.89 40 1 OG F SER 7 ? ? OG F SER 21 ? ? 1.89 41 1 OG H SER 7 ? ? OG H SER 21 ? ? 1.89 42 1 OG1 E THR 385 ? ? OH H TYR 106 ? ? 2.08 43 1 OG1 D THR 385 ? ? OH F TYR 106 ? ? 2.12 44 1 OG1 A THR 393 ? ? O A GLU 516 ? ? 2.17 45 1 OG1 D THR 393 ? ? O D GLU 516 ? ? 2.17 46 1 OG1 E THR 393 ? ? O E GLU 516 ? ? 2.17 47 1 OG1 A THR 385 ? ? OH B TYR 106 ? ? 2.17 # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 ASN E 388 ? ? -66.14 0.91 2 1 VAL H 48 ? ? -122.36 -63.27 3 1 ALA H 92 ? ? -173.09 -175.22 4 1 SER H 121 ? ? -91.02 54.36 5 1 SER L 31 ? ? -142.01 24.59 6 1 TYR L 32 ? ? -90.03 58.36 7 1 ALA L 50 ? ? 70.64 -1.78 8 1 ALA L 51 ? ? 73.71 -7.91 9 1 SER L 52 ? ? -141.13 34.04 10 1 ASN A 388 ? ? -66.10 0.84 11 1 VAL B 48 ? ? -122.36 -63.33 12 1 ALA B 92 ? ? -173.14 -175.19 13 1 SER B 121 ? ? -91.06 54.43 14 1 SER C 31 ? ? -142.02 24.61 15 1 TYR C 32 ? ? -90.00 58.32 16 1 ALA C 50 ? ? 70.62 -1.77 17 1 ALA C 51 ? ? 73.79 -7.97 18 1 SER C 52 ? ? -141.19 34.04 19 1 ASN D 388 ? ? -66.06 0.78 20 1 VAL F 48 ? ? -122.35 -63.27 21 1 ALA F 92 ? ? -173.10 -175.24 22 1 SER F 121 ? ? -91.04 54.41 23 1 SER G 31 ? ? -142.01 24.60 24 1 TYR G 32 ? ? -90.02 58.38 25 1 ALA G 50 ? ? 70.61 -1.75 26 1 ALA G 51 ? ? 73.78 -7.97 27 1 SER G 52 ? ? -141.10 34.09 # _em_3d_fitting.entry_id 6ZDG _em_3d_fitting.id 1 _em_3d_fitting.details ? _em_3d_fitting.overall_b_value ? _em_3d_fitting.ref_protocol ? _em_3d_fitting.ref_space ? _em_3d_fitting.target_criteria ? _em_3d_fitting.method ? # _em_3d_reconstruction.entry_id 6ZDG _em_3d_reconstruction.id 1 _em_3d_reconstruction.algorithm ? _em_3d_reconstruction.details ? _em_3d_reconstruction.refinement_type ? _em_3d_reconstruction.image_processing_id 1 _em_3d_reconstruction.num_class_averages ? _em_3d_reconstruction.num_particles 41372 _em_3d_reconstruction.resolution 4.7 _em_3d_reconstruction.resolution_method 'FSC 0.143 CUT-OFF' _em_3d_reconstruction.symmetry_type POINT _em_3d_reconstruction.method ? _em_3d_reconstruction.nominal_pixel_size ? _em_3d_reconstruction.actual_pixel_size ? _em_3d_reconstruction.magnification_calibration ? # _em_buffer.id 1 _em_buffer.details ? _em_buffer.pH 8.0 _em_buffer.specimen_id 1 _em_buffer.name ? # loop_ _em_entity_assembly.id _em_entity_assembly.parent_id _em_entity_assembly.details _em_entity_assembly.name _em_entity_assembly.source _em_entity_assembly.type _em_entity_assembly.entity_id_list _em_entity_assembly.synonym _em_entity_assembly.oligomeric_details 1 0 'SDS PAGE analysis shows that the Spike polypeptide remains largely uncleaved, while the density only shows S1 subunit' 'Complex of SARS-CoV-2 Spike ectodomain with EY6A Fab' RECOMBINANT COMPLEX 2,3 ? ? 2 1 ? 'SARS-CoV-2 neutralizing antibody EY6A Fab' RECOMBINANT COMPLEX 2,3 ? ? # _em_imaging.id 1 _em_imaging.entry_id 6ZDG _em_imaging.accelerating_voltage 300 _em_imaging.alignment_procedure ? _em_imaging.c2_aperture_diameter ? _em_imaging.calibrated_defocus_max ? _em_imaging.calibrated_defocus_min ? _em_imaging.calibrated_magnification ? _em_imaging.cryogen ? _em_imaging.details ? _em_imaging.electron_source 'FIELD EMISSION GUN' _em_imaging.illumination_mode 'FLOOD BEAM' _em_imaging.microscope_model 'FEI TITAN KRIOS' _em_imaging.mode 'BRIGHT FIELD' _em_imaging.nominal_cs ? _em_imaging.nominal_defocus_max ? _em_imaging.nominal_defocus_min ? _em_imaging.nominal_magnification ? _em_imaging.recording_temperature_maximum ? _em_imaging.recording_temperature_minimum ? _em_imaging.residual_tilt ? _em_imaging.specimen_holder_model ? _em_imaging.specimen_id 1 _em_imaging.citation_id ? _em_imaging.date ? _em_imaging.temperature ? _em_imaging.tilt_angle_min ? _em_imaging.tilt_angle_max ? _em_imaging.astigmatism ? _em_imaging.detector_distance ? _em_imaging.electron_beam_tilt_params ? _em_imaging.specimen_holder_type ? # _em_vitrification.id 1 _em_vitrification.specimen_id 1 _em_vitrification.chamber_temperature ? _em_vitrification.cryogen_name ETHANE-PROPANE _em_vitrification.details ? _em_vitrification.humidity ? _em_vitrification.instrument ? _em_vitrification.entry_id 6ZDG _em_vitrification.citation_id ? _em_vitrification.method ? _em_vitrification.temp ? _em_vitrification.time_resolved_state ? # _em_experiment.entry_id 6ZDG _em_experiment.id 1 _em_experiment.aggregation_state PARTICLE _em_experiment.reconstruction_method 'SINGLE PARTICLE' _em_experiment.entity_assembly_id 1 # _em_single_particle_entity.entry_id 6ZDG _em_single_particle_entity.id 1 _em_single_particle_entity.image_processing_id 1 _em_single_particle_entity.point_symmetry C3 # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 H LYS 137 ? B LYS 137 2 1 Y 1 H SER 138 ? B SER 138 3 1 Y 1 H THR 139 ? B THR 139 4 1 Y 1 H SER 140 ? B SER 140 5 1 Y 1 H GLY 141 ? B GLY 141 6 1 Y 1 H ASP 225 ? B ASP 225 7 1 Y 1 H LYS 226 ? B LYS 226 8 1 Y 1 B LYS 137 ? E LYS 137 9 1 Y 1 B SER 138 ? E SER 138 10 1 Y 1 B THR 139 ? E THR 139 11 1 Y 1 B SER 140 ? E SER 140 12 1 Y 1 B GLY 141 ? E GLY 141 13 1 Y 1 B ASP 225 ? E ASP 225 14 1 Y 1 B LYS 226 ? E LYS 226 15 1 Y 1 F LYS 137 ? H LYS 137 16 1 Y 1 F SER 138 ? H SER 138 17 1 Y 1 F THR 139 ? H THR 139 18 1 Y 1 F SER 140 ? H SER 140 19 1 Y 1 F GLY 141 ? H GLY 141 20 1 Y 1 F ASP 225 ? H ASP 225 21 1 Y 1 F LYS 226 ? H LYS 226 # loop_ _chem_comp_atom.comp_id _chem_comp_atom.atom_id _chem_comp_atom.type_symbol _chem_comp_atom.pdbx_aromatic_flag _chem_comp_atom.pdbx_stereo_config _chem_comp_atom.pdbx_ordinal ALA N N N N 1 ALA CA C N S 2 ALA C C N N 3 ALA O O N N 4 ALA CB C N N 5 ALA OXT O N N 6 ALA H H N N 7 ALA H2 H N N 8 ALA HA H N N 9 ALA HB1 H N N 10 ALA HB2 H N N 11 ALA HB3 H N N 12 ALA HXT H N N 13 ARG N N N N 14 ARG CA C N S 15 ARG C C N N 16 ARG O O N N 17 ARG CB C N N 18 ARG CG C N N 19 ARG CD C N N 20 ARG NE N N N 21 ARG CZ C N N 22 ARG NH1 N N N 23 ARG NH2 N N N 24 ARG OXT O N N 25 ARG H H N N 26 ARG H2 H N N 27 ARG HA H N N 28 ARG HB2 H N N 29 ARG HB3 H N N 30 ARG HG2 H N N 31 ARG HG3 H N N 32 ARG HD2 H N N 33 ARG HD3 H N N 34 ARG HE H N N 35 ARG HH11 H N N 36 ARG HH12 H N N 37 ARG HH21 H N N 38 ARG HH22 H N N 39 ARG HXT H N N 40 ASN N N N N 41 ASN CA C N S 42 ASN C C N N 43 ASN O O N N 44 ASN CB C N N 45 ASN CG C N N 46 ASN OD1 O N N 47 ASN ND2 N N N 48 ASN OXT O N N 49 ASN H H N N 50 ASN H2 H N N 51 ASN HA H N N 52 ASN HB2 H N N 53 ASN HB3 H N N 54 ASN HD21 H N N 55 ASN HD22 H N N 56 ASN HXT H N N 57 ASP N N N N 58 ASP CA C N S 59 ASP C C N N 60 ASP O O N N 61 ASP CB C N N 62 ASP CG C N N 63 ASP OD1 O N N 64 ASP OD2 O N N 65 ASP OXT O N N 66 ASP H H N N 67 ASP H2 H N N 68 ASP HA H N N 69 ASP HB2 H N N 70 ASP HB3 H N N 71 ASP HD2 H N N 72 ASP HXT H N N 73 CYS N N N N 74 CYS CA C N R 75 CYS C C N N 76 CYS O O N N 77 CYS CB C N N 78 CYS SG S N N 79 CYS OXT O N N 80 CYS H H N N 81 CYS H2 H N N 82 CYS HA H N N 83 CYS HB2 H N N 84 CYS HB3 H N N 85 CYS HG H N N 86 CYS HXT H N N 87 GLN N N N N 88 GLN CA C N S 89 GLN C C N N 90 GLN O O N N 91 GLN CB C N N 92 GLN CG C N N 93 GLN CD C N N 94 GLN OE1 O N N 95 GLN NE2 N N N 96 GLN OXT O N N 97 GLN H H N N 98 GLN H2 H N N 99 GLN HA H N N 100 GLN HB2 H N N 101 GLN HB3 H N N 102 GLN HG2 H N N 103 GLN HG3 H N N 104 GLN HE21 H N N 105 GLN HE22 H N N 106 GLN HXT H N N 107 GLU N N N N 108 GLU CA C N S 109 GLU C C N N 110 GLU O O N N 111 GLU CB C N N 112 GLU CG C N N 113 GLU CD C N N 114 GLU OE1 O N N 115 GLU OE2 O N N 116 GLU OXT O N N 117 GLU H H N N 118 GLU H2 H N N 119 GLU HA H N N 120 GLU HB2 H N N 121 GLU HB3 H N N 122 GLU HG2 H N N 123 GLU HG3 H N N 124 GLU HE2 H N N 125 GLU HXT H N N 126 GLY N N N N 127 GLY CA C N N 128 GLY C C N N 129 GLY O O N N 130 GLY OXT O N N 131 GLY H H N N 132 GLY H2 H N N 133 GLY HA2 H N N 134 GLY HA3 H N N 135 GLY HXT H N N 136 HIS N N N N 137 HIS CA C N S 138 HIS C C N N 139 HIS O O N N 140 HIS CB C N N 141 HIS CG C Y N 142 HIS ND1 N Y N 143 HIS CD2 C Y N 144 HIS CE1 C Y N 145 HIS NE2 N Y N 146 HIS OXT O N N 147 HIS H H N N 148 HIS H2 H N N 149 HIS HA H N N 150 HIS HB2 H N N 151 HIS HB3 H N N 152 HIS HD1 H N N 153 HIS HD2 H N N 154 HIS HE1 H N N 155 HIS HE2 H N N 156 HIS HXT H N N 157 ILE N N N N 158 ILE CA C N S 159 ILE C C N N 160 ILE O O N N 161 ILE CB C N S 162 ILE CG1 C N N 163 ILE CG2 C N N 164 ILE CD1 C N N 165 ILE OXT O N N 166 ILE H H N N 167 ILE H2 H N N 168 ILE HA H N N 169 ILE HB H N N 170 ILE HG12 H N N 171 ILE HG13 H N N 172 ILE HG21 H N N 173 ILE HG22 H N N 174 ILE HG23 H N N 175 ILE HD11 H N N 176 ILE HD12 H N N 177 ILE HD13 H N N 178 ILE HXT H N N 179 LEU N N N N 180 LEU CA C N S 181 LEU C C N N 182 LEU O O N N 183 LEU CB C N N 184 LEU CG C N N 185 LEU CD1 C N N 186 LEU CD2 C N N 187 LEU OXT O N N 188 LEU H H N N 189 LEU H2 H N N 190 LEU HA H N N 191 LEU HB2 H N N 192 LEU HB3 H N N 193 LEU HG H N N 194 LEU HD11 H N N 195 LEU HD12 H N N 196 LEU HD13 H N N 197 LEU HD21 H N N 198 LEU HD22 H N N 199 LEU HD23 H N N 200 LEU HXT H N N 201 LYS N N N N 202 LYS CA C N S 203 LYS C C N N 204 LYS O O N N 205 LYS CB C N N 206 LYS CG C N N 207 LYS CD C N N 208 LYS CE C N N 209 LYS NZ N N N 210 LYS OXT O N N 211 LYS H H N N 212 LYS H2 H N N 213 LYS HA H N N 214 LYS HB2 H N N 215 LYS HB3 H N N 216 LYS HG2 H N N 217 LYS HG3 H N N 218 LYS HD2 H N N 219 LYS HD3 H N N 220 LYS HE2 H N N 221 LYS HE3 H N N 222 LYS HZ1 H N N 223 LYS HZ2 H N N 224 LYS HZ3 H N N 225 LYS HXT H N N 226 MET N N N N 227 MET CA C N S 228 MET C C N N 229 MET O O N N 230 MET CB C N N 231 MET CG C N N 232 MET SD S N N 233 MET CE C N N 234 MET OXT O N N 235 MET H H N N 236 MET H2 H N N 237 MET HA H N N 238 MET HB2 H N N 239 MET HB3 H N N 240 MET HG2 H N N 241 MET HG3 H N N 242 MET HE1 H N N 243 MET HE2 H N N 244 MET HE3 H N N 245 MET HXT H N N 246 NAG C1 C N R 247 NAG C2 C N R 248 NAG C3 C N R 249 NAG C4 C N S 250 NAG C5 C N R 251 NAG C6 C N N 252 NAG C7 C N N 253 NAG C8 C N N 254 NAG N2 N N N 255 NAG O1 O N N 256 NAG O3 O N N 257 NAG O4 O N N 258 NAG O5 O N N 259 NAG O6 O N N 260 NAG O7 O N N 261 NAG H1 H N N 262 NAG H2 H N N 263 NAG H3 H N N 264 NAG H4 H N N 265 NAG H5 H N N 266 NAG H61 H N N 267 NAG H62 H N N 268 NAG H81 H N N 269 NAG H82 H N N 270 NAG H83 H N N 271 NAG HN2 H N N 272 NAG HO1 H N N 273 NAG HO3 H N N 274 NAG HO4 H N N 275 NAG HO6 H N N 276 PHE N N N N 277 PHE CA C N S 278 PHE C C N N 279 PHE O O N N 280 PHE CB C N N 281 PHE CG C Y N 282 PHE CD1 C Y N 283 PHE CD2 C Y N 284 PHE CE1 C Y N 285 PHE CE2 C Y N 286 PHE CZ C Y N 287 PHE OXT O N N 288 PHE H H N N 289 PHE H2 H N N 290 PHE HA H N N 291 PHE HB2 H N N 292 PHE HB3 H N N 293 PHE HD1 H N N 294 PHE HD2 H N N 295 PHE HE1 H N N 296 PHE HE2 H N N 297 PHE HZ H N N 298 PHE HXT H N N 299 PRO N N N N 300 PRO CA C N S 301 PRO C C N N 302 PRO O O N N 303 PRO CB C N N 304 PRO CG C N N 305 PRO CD C N N 306 PRO OXT O N N 307 PRO H H N N 308 PRO HA H N N 309 PRO HB2 H N N 310 PRO HB3 H N N 311 PRO HG2 H N N 312 PRO HG3 H N N 313 PRO HD2 H N N 314 PRO HD3 H N N 315 PRO HXT H N N 316 SER N N N N 317 SER CA C N S 318 SER C C N N 319 SER O O N N 320 SER CB C N N 321 SER OG O N N 322 SER OXT O N N 323 SER H H N N 324 SER H2 H N N 325 SER HA H N N 326 SER HB2 H N N 327 SER HB3 H N N 328 SER HG H N N 329 SER HXT H N N 330 THR N N N N 331 THR CA C N S 332 THR C C N N 333 THR O O N N 334 THR CB C N R 335 THR OG1 O N N 336 THR CG2 C N N 337 THR OXT O N N 338 THR H H N N 339 THR H2 H N N 340 THR HA H N N 341 THR HB H N N 342 THR HG1 H N N 343 THR HG21 H N N 344 THR HG22 H N N 345 THR HG23 H N N 346 THR HXT H N N 347 TRP N N N N 348 TRP CA C N S 349 TRP C C N N 350 TRP O O N N 351 TRP CB C N N 352 TRP CG C Y N 353 TRP CD1 C Y N 354 TRP CD2 C Y N 355 TRP NE1 N Y N 356 TRP CE2 C Y N 357 TRP CE3 C Y N 358 TRP CZ2 C Y N 359 TRP CZ3 C Y N 360 TRP CH2 C Y N 361 TRP OXT O N N 362 TRP H H N N 363 TRP H2 H N N 364 TRP HA H N N 365 TRP HB2 H N N 366 TRP HB3 H N N 367 TRP HD1 H N N 368 TRP HE1 H N N 369 TRP HE3 H N N 370 TRP HZ2 H N N 371 TRP HZ3 H N N 372 TRP HH2 H N N 373 TRP HXT H N N 374 TYR N N N N 375 TYR CA C N S 376 TYR C C N N 377 TYR O O N N 378 TYR CB C N N 379 TYR CG C Y N 380 TYR CD1 C Y N 381 TYR CD2 C Y N 382 TYR CE1 C Y N 383 TYR CE2 C Y N 384 TYR CZ C Y N 385 TYR OH O N N 386 TYR OXT O N N 387 TYR H H N N 388 TYR H2 H N N 389 TYR HA H N N 390 TYR HB2 H N N 391 TYR HB3 H N N 392 TYR HD1 H N N 393 TYR HD2 H N N 394 TYR HE1 H N N 395 TYR HE2 H N N 396 TYR HH H N N 397 TYR HXT H N N 398 VAL N N N N 399 VAL CA C N S 400 VAL C C N N 401 VAL O O N N 402 VAL CB C N N 403 VAL CG1 C N N 404 VAL CG2 C N N 405 VAL OXT O N N 406 VAL H H N N 407 VAL H2 H N N 408 VAL HA H N N 409 VAL HB H N N 410 VAL HG11 H N N 411 VAL HG12 H N N 412 VAL HG13 H N N 413 VAL HG21 H N N 414 VAL HG22 H N N 415 VAL HG23 H N N 416 VAL HXT H N N 417 # loop_ _chem_comp_bond.comp_id _chem_comp_bond.atom_id_1 _chem_comp_bond.atom_id_2 _chem_comp_bond.value_order _chem_comp_bond.pdbx_aromatic_flag _chem_comp_bond.pdbx_stereo_config _chem_comp_bond.pdbx_ordinal ALA N CA sing N N 1 ALA N H sing N N 2 ALA N H2 sing N N 3 ALA CA C sing N N 4 ALA CA CB sing N N 5 ALA CA HA sing N N 6 ALA C O doub N N 7 ALA C OXT sing N N 8 ALA CB HB1 sing N N 9 ALA CB HB2 sing N N 10 ALA CB HB3 sing N N 11 ALA OXT HXT sing N N 12 ARG N CA sing N N 13 ARG N H sing N N 14 ARG N H2 sing N N 15 ARG CA C sing N N 16 ARG CA CB sing N N 17 ARG CA HA sing N N 18 ARG C O doub N N 19 ARG C OXT sing N N 20 ARG CB CG sing N N 21 ARG CB HB2 sing N N 22 ARG CB HB3 sing N N 23 ARG CG CD sing N N 24 ARG CG HG2 sing N N 25 ARG CG HG3 sing N N 26 ARG CD NE sing N N 27 ARG CD HD2 sing N N 28 ARG CD HD3 sing N N 29 ARG NE CZ sing N N 30 ARG NE HE sing N N 31 ARG CZ NH1 sing N N 32 ARG CZ NH2 doub N N 33 ARG NH1 HH11 sing N N 34 ARG NH1 HH12 sing N N 35 ARG NH2 HH21 sing N N 36 ARG NH2 HH22 sing N N 37 ARG OXT HXT sing N N 38 ASN N CA sing N N 39 ASN N H sing N N 40 ASN N H2 sing N N 41 ASN CA C sing N N 42 ASN CA CB sing N N 43 ASN CA HA sing N N 44 ASN C O doub N N 45 ASN C OXT sing N N 46 ASN CB CG sing N N 47 ASN CB HB2 sing N N 48 ASN CB HB3 sing N N 49 ASN CG OD1 doub N N 50 ASN CG ND2 sing N N 51 ASN ND2 HD21 sing N N 52 ASN ND2 HD22 sing N N 53 ASN OXT HXT sing N N 54 ASP N CA sing N N 55 ASP N H sing N N 56 ASP N H2 sing N N 57 ASP CA C sing N N 58 ASP CA CB sing N N 59 ASP CA HA sing N N 60 ASP C O doub N N 61 ASP C OXT sing N N 62 ASP CB CG sing N N 63 ASP CB HB2 sing N N 64 ASP CB HB3 sing N N 65 ASP CG OD1 doub N N 66 ASP CG OD2 sing N N 67 ASP OD2 HD2 sing N N 68 ASP OXT HXT sing N N 69 CYS N CA sing N N 70 CYS N H sing N N 71 CYS N H2 sing N N 72 CYS CA C sing N N 73 CYS CA CB sing N N 74 CYS CA HA sing N N 75 CYS C O doub N N 76 CYS C OXT sing N N 77 CYS CB SG sing N N 78 CYS CB HB2 sing N N 79 CYS CB HB3 sing N N 80 CYS SG HG sing N N 81 CYS OXT HXT sing N N 82 GLN N CA sing N N 83 GLN N H sing N N 84 GLN N H2 sing N N 85 GLN CA C sing N N 86 GLN CA CB sing N N 87 GLN CA HA sing N N 88 GLN C O doub N N 89 GLN C OXT sing N N 90 GLN CB CG sing N N 91 GLN CB HB2 sing N N 92 GLN CB HB3 sing N N 93 GLN CG CD sing N N 94 GLN CG HG2 sing N N 95 GLN CG HG3 sing N N 96 GLN CD OE1 doub N N 97 GLN CD NE2 sing N N 98 GLN NE2 HE21 sing N N 99 GLN NE2 HE22 sing N N 100 GLN OXT HXT sing N N 101 GLU N CA sing N N 102 GLU N H sing N N 103 GLU N H2 sing N N 104 GLU CA C sing N N 105 GLU CA CB sing N N 106 GLU CA HA sing N N 107 GLU C O doub N N 108 GLU C OXT sing N N 109 GLU CB CG sing N N 110 GLU CB HB2 sing N N 111 GLU CB HB3 sing N N 112 GLU CG CD sing N N 113 GLU CG HG2 sing N N 114 GLU CG HG3 sing N N 115 GLU CD OE1 doub N N 116 GLU CD OE2 sing N N 117 GLU OE2 HE2 sing N N 118 GLU OXT HXT sing N N 119 GLY N CA sing N N 120 GLY N H sing N N 121 GLY N H2 sing N N 122 GLY CA C sing N N 123 GLY CA HA2 sing N N 124 GLY CA HA3 sing N N 125 GLY C O doub N N 126 GLY C OXT sing N N 127 GLY OXT HXT sing N N 128 HIS N CA sing N N 129 HIS N H sing N N 130 HIS N H2 sing N N 131 HIS CA C sing N N 132 HIS CA CB sing N N 133 HIS CA HA sing N N 134 HIS C O doub N N 135 HIS C OXT sing N N 136 HIS CB CG sing N N 137 HIS CB HB2 sing N N 138 HIS CB HB3 sing N N 139 HIS CG ND1 sing Y N 140 HIS CG CD2 doub Y N 141 HIS ND1 CE1 doub Y N 142 HIS ND1 HD1 sing N N 143 HIS CD2 NE2 sing Y N 144 HIS CD2 HD2 sing N N 145 HIS CE1 NE2 sing Y N 146 HIS CE1 HE1 sing N N 147 HIS NE2 HE2 sing N N 148 HIS OXT HXT sing N N 149 ILE N CA sing N N 150 ILE N H sing N N 151 ILE N H2 sing N N 152 ILE CA C sing N N 153 ILE CA CB sing N N 154 ILE CA HA sing N N 155 ILE C O doub N N 156 ILE C OXT sing N N 157 ILE CB CG1 sing N N 158 ILE CB CG2 sing N N 159 ILE CB HB sing N N 160 ILE CG1 CD1 sing N N 161 ILE CG1 HG12 sing N N 162 ILE CG1 HG13 sing N N 163 ILE CG2 HG21 sing N N 164 ILE CG2 HG22 sing N N 165 ILE CG2 HG23 sing N N 166 ILE CD1 HD11 sing N N 167 ILE CD1 HD12 sing N N 168 ILE CD1 HD13 sing N N 169 ILE OXT HXT sing N N 170 LEU N CA sing N N 171 LEU N H sing N N 172 LEU N H2 sing N N 173 LEU CA C sing N N 174 LEU CA CB sing N N 175 LEU CA HA sing N N 176 LEU C O doub N N 177 LEU C OXT sing N N 178 LEU CB CG sing N N 179 LEU CB HB2 sing N N 180 LEU CB HB3 sing N N 181 LEU CG CD1 sing N N 182 LEU CG CD2 sing N N 183 LEU CG HG sing N N 184 LEU CD1 HD11 sing N N 185 LEU CD1 HD12 sing N N 186 LEU CD1 HD13 sing N N 187 LEU CD2 HD21 sing N N 188 LEU CD2 HD22 sing N N 189 LEU CD2 HD23 sing N N 190 LEU OXT HXT sing N N 191 LYS N CA sing N N 192 LYS N H sing N N 193 LYS N H2 sing N N 194 LYS CA C sing N N 195 LYS CA CB sing N N 196 LYS CA HA sing N N 197 LYS C O doub N N 198 LYS C OXT sing N N 199 LYS CB CG sing N N 200 LYS CB HB2 sing N N 201 LYS CB HB3 sing N N 202 LYS CG CD sing N N 203 LYS CG HG2 sing N N 204 LYS CG HG3 sing N N 205 LYS CD CE sing N N 206 LYS CD HD2 sing N N 207 LYS CD HD3 sing N N 208 LYS CE NZ sing N N 209 LYS CE HE2 sing N N 210 LYS CE HE3 sing N N 211 LYS NZ HZ1 sing N N 212 LYS NZ HZ2 sing N N 213 LYS NZ HZ3 sing N N 214 LYS OXT HXT sing N N 215 MET N CA sing N N 216 MET N H sing N N 217 MET N H2 sing N N 218 MET CA C sing N N 219 MET CA CB sing N N 220 MET CA HA sing N N 221 MET C O doub N N 222 MET C OXT sing N N 223 MET CB CG sing N N 224 MET CB HB2 sing N N 225 MET CB HB3 sing N N 226 MET CG SD sing N N 227 MET CG HG2 sing N N 228 MET CG HG3 sing N N 229 MET SD CE sing N N 230 MET CE HE1 sing N N 231 MET CE HE2 sing N N 232 MET CE HE3 sing N N 233 MET OXT HXT sing N N 234 NAG C1 C2 sing N N 235 NAG C1 O1 sing N N 236 NAG C1 O5 sing N N 237 NAG C1 H1 sing N N 238 NAG C2 C3 sing N N 239 NAG C2 N2 sing N N 240 NAG C2 H2 sing N N 241 NAG C3 C4 sing N N 242 NAG C3 O3 sing N N 243 NAG C3 H3 sing N N 244 NAG C4 C5 sing N N 245 NAG C4 O4 sing N N 246 NAG C4 H4 sing N N 247 NAG C5 C6 sing N N 248 NAG C5 O5 sing N N 249 NAG C5 H5 sing N N 250 NAG C6 O6 sing N N 251 NAG C6 H61 sing N N 252 NAG C6 H62 sing N N 253 NAG C7 C8 sing N N 254 NAG C7 N2 sing N N 255 NAG C7 O7 doub N N 256 NAG C8 H81 sing N N 257 NAG C8 H82 sing N N 258 NAG C8 H83 sing N N 259 NAG N2 HN2 sing N N 260 NAG O1 HO1 sing N N 261 NAG O3 HO3 sing N N 262 NAG O4 HO4 sing N N 263 NAG O6 HO6 sing N N 264 PHE N CA sing N N 265 PHE N H sing N N 266 PHE N H2 sing N N 267 PHE CA C sing N N 268 PHE CA CB sing N N 269 PHE CA HA sing N N 270 PHE C O doub N N 271 PHE C OXT sing N N 272 PHE CB CG sing N N 273 PHE CB HB2 sing N N 274 PHE CB HB3 sing N N 275 PHE CG CD1 doub Y N 276 PHE CG CD2 sing Y N 277 PHE CD1 CE1 sing Y N 278 PHE CD1 HD1 sing N N 279 PHE CD2 CE2 doub Y N 280 PHE CD2 HD2 sing N N 281 PHE CE1 CZ doub Y N 282 PHE CE1 HE1 sing N N 283 PHE CE2 CZ sing Y N 284 PHE CE2 HE2 sing N N 285 PHE CZ HZ sing N N 286 PHE OXT HXT sing N N 287 PRO N CA sing N N 288 PRO N CD sing N N 289 PRO N H sing N N 290 PRO CA C sing N N 291 PRO CA CB sing N N 292 PRO CA HA sing N N 293 PRO C O doub N N 294 PRO C OXT sing N N 295 PRO CB CG sing N N 296 PRO CB HB2 sing N N 297 PRO CB HB3 sing N N 298 PRO CG CD sing N N 299 PRO CG HG2 sing N N 300 PRO CG HG3 sing N N 301 PRO CD HD2 sing N N 302 PRO CD HD3 sing N N 303 PRO OXT HXT sing N N 304 SER N CA sing N N 305 SER N H sing N N 306 SER N H2 sing N N 307 SER CA C sing N N 308 SER CA CB sing N N 309 SER CA HA sing N N 310 SER C O doub N N 311 SER C OXT sing N N 312 SER CB OG sing N N 313 SER CB HB2 sing N N 314 SER CB HB3 sing N N 315 SER OG HG sing N N 316 SER OXT HXT sing N N 317 THR N CA sing N N 318 THR N H sing N N 319 THR N H2 sing N N 320 THR CA C sing N N 321 THR CA CB sing N N 322 THR CA HA sing N N 323 THR C O doub N N 324 THR C OXT sing N N 325 THR CB OG1 sing N N 326 THR CB CG2 sing N N 327 THR CB HB sing N N 328 THR OG1 HG1 sing N N 329 THR CG2 HG21 sing N N 330 THR CG2 HG22 sing N N 331 THR CG2 HG23 sing N N 332 THR OXT HXT sing N N 333 TRP N CA sing N N 334 TRP N H sing N N 335 TRP N H2 sing N N 336 TRP CA C sing N N 337 TRP CA CB sing N N 338 TRP CA HA sing N N 339 TRP C O doub N N 340 TRP C OXT sing N N 341 TRP CB CG sing N N 342 TRP CB HB2 sing N N 343 TRP CB HB3 sing N N 344 TRP CG CD1 doub Y N 345 TRP CG CD2 sing Y N 346 TRP CD1 NE1 sing Y N 347 TRP CD1 HD1 sing N N 348 TRP CD2 CE2 doub Y N 349 TRP CD2 CE3 sing Y N 350 TRP NE1 CE2 sing Y N 351 TRP NE1 HE1 sing N N 352 TRP CE2 CZ2 sing Y N 353 TRP CE3 CZ3 doub Y N 354 TRP CE3 HE3 sing N N 355 TRP CZ2 CH2 doub Y N 356 TRP CZ2 HZ2 sing N N 357 TRP CZ3 CH2 sing Y N 358 TRP CZ3 HZ3 sing N N 359 TRP CH2 HH2 sing N N 360 TRP OXT HXT sing N N 361 TYR N CA sing N N 362 TYR N H sing N N 363 TYR N H2 sing N N 364 TYR CA C sing N N 365 TYR CA CB sing N N 366 TYR CA HA sing N N 367 TYR C O doub N N 368 TYR C OXT sing N N 369 TYR CB CG sing N N 370 TYR CB HB2 sing N N 371 TYR CB HB3 sing N N 372 TYR CG CD1 doub Y N 373 TYR CG CD2 sing Y N 374 TYR CD1 CE1 sing Y N 375 TYR CD1 HD1 sing N N 376 TYR CD2 CE2 doub Y N 377 TYR CD2 HD2 sing N N 378 TYR CE1 CZ doub Y N 379 TYR CE1 HE1 sing N N 380 TYR CE2 CZ sing Y N 381 TYR CE2 HE2 sing N N 382 TYR CZ OH sing N N 383 TYR OH HH sing N N 384 TYR OXT HXT sing N N 385 VAL N CA sing N N 386 VAL N H sing N N 387 VAL N H2 sing N N 388 VAL CA C sing N N 389 VAL CA CB sing N N 390 VAL CA HA sing N N 391 VAL C O doub N N 392 VAL C OXT sing N N 393 VAL CB CG1 sing N N 394 VAL CB CG2 sing N N 395 VAL CB HB sing N N 396 VAL CG1 HG11 sing N N 397 VAL CG1 HG12 sing N N 398 VAL CG1 HG13 sing N N 399 VAL CG2 HG21 sing N N 400 VAL CG2 HG22 sing N N 401 VAL CG2 HG23 sing N N 402 VAL OXT HXT sing N N 403 # _em_admin.entry_id 6ZDG _em_admin.current_status REL _em_admin.deposition_date 2020-06-14 _em_admin.deposition_site PDBE _em_admin.last_update 2024-11-20 _em_admin.map_release_date 2020-07-29 _em_admin.title 'Association of three complexes of largely structurally disordered Spike ectodomain with bound EY6A Fab' # _em_ctf_correction.id 1 _em_ctf_correction.em_image_processing_id 1 _em_ctf_correction.type 'PHASE FLIPPING AND AMPLITUDE CORRECTION' _em_ctf_correction.details ? # loop_ _em_entity_assembly_naturalsource.id _em_entity_assembly_naturalsource.entity_assembly_id _em_entity_assembly_naturalsource.cell _em_entity_assembly_naturalsource.cellular_location _em_entity_assembly_naturalsource.ncbi_tax_id _em_entity_assembly_naturalsource.organ _em_entity_assembly_naturalsource.organelle _em_entity_assembly_naturalsource.organism _em_entity_assembly_naturalsource.strain _em_entity_assembly_naturalsource.tissue 2 1 ? ? 2697049 ? ? 'Severe acute respiratory syndrome coronavirus 2' ? ? 3 2 ? ? 2697049 ? ? human ? ? # loop_ _em_entity_assembly_recombinant.id _em_entity_assembly_recombinant.entity_assembly_id _em_entity_assembly_recombinant.cell _em_entity_assembly_recombinant.ncbi_tax_id _em_entity_assembly_recombinant.organism _em_entity_assembly_recombinant.plasmid _em_entity_assembly_recombinant.strain 2 1 ? 9606 'Homo sapiens' ? ? 3 2 ? 10029 'Cricetulus griseus' ? ? # _em_image_processing.id 1 _em_image_processing.image_recording_id 1 _em_image_processing.details ? # _em_image_recording.id 1 _em_image_recording.imaging_id 1 _em_image_recording.avg_electron_dose_per_image 42.2 _em_image_recording.average_exposure_time ? _em_image_recording.details ? _em_image_recording.detector_mode ? _em_image_recording.film_or_detector_model 'GATAN K3 (6k x 4k)' _em_image_recording.num_diffraction_images ? _em_image_recording.num_grids_imaged ? _em_image_recording.num_real_images ? # loop_ _em_software.id _em_software.category _em_software.details _em_software.name _em_software.version _em_software.image_processing_id _em_software.fitting_id _em_software.imaging_id 1 'PARTICLE SELECTION' ? cryoSPARC ? 1 ? ? 2 'IMAGE ACQUISITION' ? ? ? ? ? 1 3 MASKING ? ? ? ? ? ? 4 'CTF CORRECTION' ? Gctf ? 1 ? ? 5 'LAYERLINE INDEXING' ? ? ? ? ? ? 6 'DIFFRACTION INDEXING' ? ? ? ? ? ? 7 'MODEL FITTING' ? ? ? ? ? ? 8 'MODEL REFINEMENT' ? ? ? ? ? ? 9 OTHER ? ? ? ? ? ? 10 'INITIAL EULER ASSIGNMENT' ? ? ? 1 ? ? 11 'FINAL EULER ASSIGNMENT' ? cryoSPARC ? 1 ? ? 12 CLASSIFICATION ? cryoSPARC ? 1 ? ? 13 RECONSTRUCTION ? cryoSPARC ? 1 ? ? # _em_specimen.id 1 _em_specimen.experiment_id 1 _em_specimen.concentration ? _em_specimen.details ? _em_specimen.embedding_applied NO _em_specimen.shadowing_applied NO _em_specimen.staining_applied NO _em_specimen.vitrification_applied YES # loop_ _pdbx_audit_support.funding_organization _pdbx_audit_support.country _pdbx_audit_support.grant_number _pdbx_audit_support.ordinal 'Medical Research Council (MRC, United Kingdom)' 'United Kingdom' MR/N00065X/1 1 'Wellcome Trust' 'United Kingdom' 101122/Z/13/Z 2 'CAMS Innovation Fund for Medical Sciences (CIFMS)' China 2018-I2M-2-002 3 # _atom_sites.entry_id 6ZDG _atom_sites.Cartn_transf_matrix[1][1] ? _atom_sites.Cartn_transf_matrix[1][2] ? _atom_sites.Cartn_transf_matrix[1][3] ? _atom_sites.Cartn_transf_matrix[2][1] ? _atom_sites.Cartn_transf_matrix[2][2] ? _atom_sites.Cartn_transf_matrix[2][3] ? _atom_sites.Cartn_transf_matrix[3][1] ? _atom_sites.Cartn_transf_matrix[3][2] ? _atom_sites.Cartn_transf_matrix[3][3] ? _atom_sites.Cartn_transf_vector[1] ? _atom_sites.Cartn_transf_vector[2] ? _atom_sites.Cartn_transf_vector[3] ? _atom_sites.fract_transf_matrix[1][1] 1.000000 _atom_sites.fract_transf_matrix[1][2] 0.000000 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 1.000000 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 1.000000 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 _atom_sites.solution_primary ? _atom_sites.solution_secondary ? _atom_sites.solution_hydrogens ? _atom_sites.special_details ? # loop_ _atom_type.symbol C H N O S # loop_