HEADER VIRAL PROTEIN 14-MAR-22 7UB6 TITLE SARS-COV-2 OMICRON-BA.2 3-RBD DOWN SPIKE PROTEIN TRIMER WITHOUT THE TITLE 2 P986-P987 STABILIZING MUTATIONS (S-GSAS-OMICRON-BA.2) COMPND MOL_ID: 1; COMPND 2 MOLECULE: SPIKE GLYCOPROTEIN; COMPND 3 CHAIN: A, B, C; COMPND 4 SYNONYM: S GLYCOPROTEIN,E2,PEPLOMER PROTEIN; COMPND 5 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS SOURCE 3 2; SOURCE 4 ORGANISM_TAXID: 2697049; SOURCE 5 GENE: S, 2; SOURCE 6 EXPRESSION_SYSTEM: MAMMALIA; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 40674 KEYWDS OMICRON SPIKE PROTEIN, SARS-COV-2, VARIANT OF CONCERN, 3-DOWN, VIRAL KEYWDS 2 PROTEIN, OMICRON-BA.2, BA.2 EXPDTA ELECTRON MICROSCOPY AUTHOR V.STALLS,P.ACHARYA REVDAT 5 20-NOV-24 7UB6 1 REMARK REVDAT 4 13-JUL-22 7UB6 1 JRNL REVDAT 3 06-JUL-22 7UB6 1 JRNL REVDAT 2 27-APR-22 7UB6 1 SOURCE SEQADV REVDAT 1 20-APR-22 7UB6 0 JRNL AUTH V.STALLS,J.LINDENBERGER,S.M.GOBEIL,R.HENDERSON,R.PARKS, JRNL AUTH 2 M.BARR,M.DEYTON,M.MARTIN,K.JANOWSKA,X.HUANG,A.MAY, JRNL AUTH 3 M.SPEAKMAN,E.BEAUDOIN,B.KRAFT,X.LU,R.J.EDWARDS,A.EATON, JRNL AUTH 4 D.C.MONTEFIORI,W.B.WILLIAMS,K.O.SAUNDERS,K.WIEHE,B.F.HAYNES, JRNL AUTH 5 P.ACHARYA JRNL TITL CRYO-EM STRUCTURES OF SARS-COV-2 OMICRON BA.2 SPIKE. JRNL REF CELL REP V. 39 11009 2022 JRNL REFN ESSN 2211-1247 JRNL PMID 35732171 JRNL DOI 10.1016/J.CELREP.2022.111009 REMARK 2 REMARK 2 RESOLUTION. 3.52 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : EPU, CRYOSPARC, COOT, ISOLDE, PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : 7KDK REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : FLEXIBLE FIT REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.520 REMARK 3 NUMBER OF PARTICLES : 198211 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 7UB6 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 15-MAR-22. REMARK 100 THE DEPOSITION ID IS D_1000263879. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : SARS-COV-2 S-GSAS-OMICRON-BA.2 REMARK 245 SPIKE ECTODOMAIN REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 1.50 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 8.00 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 11742 REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 (6K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 800.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2600.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : 2.70 REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5470.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TRIMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A 4 REMARK 465 PHE A 5 REMARK 465 VAL A 6 REMARK 465 PHE A 7 REMARK 465 LEU A 8 REMARK 465 VAL A 9 REMARK 465 LEU A 10 REMARK 465 LEU A 11 REMARK 465 PRO A 12 REMARK 465 LEU A 13 REMARK 465 VAL A 14 REMARK 465 SER A 15 REMARK 465 SER A 16 REMARK 465 GLN A 17 REMARK 465 CYS A 18 REMARK 465 VAL A 19 REMARK 465 ASN A 20 REMARK 465 LEU A 21 REMARK 465 ILE A 22 REMARK 465 THR A 23 REMARK 465 VAL A 70 REMARK 465 SER A 71 REMARK 465 GLY A 72 REMARK 465 THR A 73 REMARK 465 ASN A 74 REMARK 465 GLY A 75 REMARK 465 THR A 76 REMARK 465 LYS A 77 REMARK 465 ARG A 78 REMARK 465 PHE A 79 REMARK 465 HIS A 146 REMARK 465 LYS A 147 REMARK 465 ASN A 148 REMARK 465 ASN A 149 REMARK 465 LYS A 150 REMARK 465 SER A 151 REMARK 465 TRP A 152 REMARK 465 MET A 153 REMARK 465 GLU A 154 REMARK 465 SER A 155 REMARK 465 GLU A 156 REMARK 465 PHE A 157 REMARK 465 ARG A 158 REMARK 465 VAL A 159 REMARK 465 TYR A 160 REMARK 465 SER A 161 REMARK 465 SER A 162 REMARK 465 ASP A 178 REMARK 465 LEU A 179 REMARK 465 GLU A 180 REMARK 465 GLY A 181 REMARK 465 LYS A 182 REMARK 465 GLN A 183 REMARK 465 GLY A 184 REMARK 465 ASN A 185 REMARK 465 PHE A 186 REMARK 465 ARG A 246 REMARK 465 SER A 247 REMARK 465 TYR A 248 REMARK 465 LEU A 249 REMARK 465 THR A 250 REMARK 465 PRO A 251 REMARK 465 GLY A 252 REMARK 465 ASP A 253 REMARK 465 SER A 254 REMARK 465 SER A 255 REMARK 465 SER A 256 REMARK 465 GLY A 257 REMARK 465 TRP A 258 REMARK 465 THR A 259 REMARK 465 ALA A 260 REMARK 465 GLY A 261 REMARK 465 ALA A 623 REMARK 465 ILE A 624 REMARK 465 HIS A 625 REMARK 465 ALA A 626 REMARK 465 ASP A 627 REMARK 465 GLN A 628 REMARK 465 LEU A 629 REMARK 465 THR A 630 REMARK 465 PRO A 631 REMARK 465 THR A 632 REMARK 465 TRP A 633 REMARK 465 ARG A 634 REMARK 465 VAL A 635 REMARK 465 TYR A 636 REMARK 465 SER A 637 REMARK 465 THR A 638 REMARK 465 GLY A 639 REMARK 465 SER A 640 REMARK 465 GLN A 677 REMARK 465 THR A 678 REMARK 465 LYS A 679 REMARK 465 SER A 680 REMARK 465 HIS A 681 REMARK 465 GLY A 682 REMARK 465 SER A 683 REMARK 465 ALA A 684 REMARK 465 SER A 685 REMARK 465 SER A 686 REMARK 465 VAL A 687 REMARK 465 ALA A 688 REMARK 465 PHE A 1148 REMARK 465 LYS A 1149 REMARK 465 GLU A 1150 REMARK 465 GLU A 1151 REMARK 465 LEU A 1152 REMARK 465 ASP A 1153 REMARK 465 LYS A 1154 REMARK 465 TYR A 1155 REMARK 465 PHE A 1156 REMARK 465 LYS A 1157 REMARK 465 ASN A 1158 REMARK 465 HIS A 1159 REMARK 465 THR A 1160 REMARK 465 SER A 1161 REMARK 465 PRO A 1162 REMARK 465 ASP A 1163 REMARK 465 VAL A 1164 REMARK 465 ASP A 1165 REMARK 465 LEU A 1166 REMARK 465 GLY A 1167 REMARK 465 ASP A 1168 REMARK 465 ILE A 1169 REMARK 465 SER A 1170 REMARK 465 GLY A 1171 REMARK 465 ILE A 1172 REMARK 465 ASN A 1173 REMARK 465 ALA A 1174 REMARK 465 SER A 1175 REMARK 465 VAL A 1176 REMARK 465 VAL A 1177 REMARK 465 ASN A 1178 REMARK 465 ILE A 1179 REMARK 465 GLN A 1180 REMARK 465 LYS A 1181 REMARK 465 GLU A 1182 REMARK 465 ILE A 1183 REMARK 465 ASP A 1184 REMARK 465 ARG A 1185 REMARK 465 LEU A 1186 REMARK 465 ASN A 1187 REMARK 465 GLU A 1188 REMARK 465 VAL A 1189 REMARK 465 ALA A 1190 REMARK 465 LYS A 1191 REMARK 465 ASN A 1192 REMARK 465 LEU A 1193 REMARK 465 ASN A 1194 REMARK 465 GLU A 1195 REMARK 465 SER A 1196 REMARK 465 LEU A 1197 REMARK 465 ILE A 1198 REMARK 465 ASP A 1199 REMARK 465 LEU A 1200 REMARK 465 GLN A 1201 REMARK 465 GLU A 1202 REMARK 465 LEU A 1203 REMARK 465 GLY A 1204 REMARK 465 LYS A 1205 REMARK 465 TYR A 1206 REMARK 465 GLU A 1207 REMARK 465 GLN A 1208 REMARK 465 GLY A 1209 REMARK 465 SER A 1210 REMARK 465 GLY A 1211 REMARK 465 TYR A 1212 REMARK 465 ILE A 1213 REMARK 465 PRO A 1214 REMARK 465 GLU A 1215 REMARK 465 ALA A 1216 REMARK 465 PRO A 1217 REMARK 465 ARG A 1218 REMARK 465 ASP A 1219 REMARK 465 GLY A 1220 REMARK 465 GLN A 1221 REMARK 465 ALA A 1222 REMARK 465 TYR A 1223 REMARK 465 VAL A 1224 REMARK 465 ARG A 1225 REMARK 465 LYS A 1226 REMARK 465 ASP A 1227 REMARK 465 GLY A 1228 REMARK 465 GLU A 1229 REMARK 465 TRP A 1230 REMARK 465 VAL A 1231 REMARK 465 LEU A 1232 REMARK 465 LEU A 1233 REMARK 465 SER A 1234 REMARK 465 THR A 1235 REMARK 465 PHE A 1236 REMARK 465 LEU A 1237 REMARK 465 GLY A 1238 REMARK 465 ARG A 1239 REMARK 465 SER A 1240 REMARK 465 LEU A 1241 REMARK 465 GLU A 1242 REMARK 465 VAL A 1243 REMARK 465 LEU A 1244 REMARK 465 PHE A 1245 REMARK 465 GLN A 1246 REMARK 465 GLY A 1247 REMARK 465 PRO A 1248 REMARK 465 GLY A 1249 REMARK 465 HIS A 1250 REMARK 465 HIS A 1251 REMARK 465 HIS A 1252 REMARK 465 HIS A 1253 REMARK 465 HIS A 1254 REMARK 465 HIS A 1255 REMARK 465 HIS A 1256 REMARK 465 HIS A 1257 REMARK 465 SER A 1258 REMARK 465 ALA A 1259 REMARK 465 TRP A 1260 REMARK 465 SER A 1261 REMARK 465 HIS A 1262 REMARK 465 PRO A 1263 REMARK 465 GLN A 1264 REMARK 465 PHE A 1265 REMARK 465 GLU A 1266 REMARK 465 LYS A 1267 REMARK 465 GLY A 1268 REMARK 465 GLY A 1269 REMARK 465 GLY A 1270 REMARK 465 SER A 1271 REMARK 465 GLY A 1272 REMARK 465 GLY A 1273 REMARK 465 GLY A 1274 REMARK 465 GLY A 1275 REMARK 465 SER A 1276 REMARK 465 GLY A 1277 REMARK 465 GLY A 1278 REMARK 465 SER A 1279 REMARK 465 ALA A 1280 REMARK 465 TRP A 1281 REMARK 465 SER A 1282 REMARK 465 HIS A 1283 REMARK 465 PRO A 1284 REMARK 465 GLN A 1285 REMARK 465 PHE A 1286 REMARK 465 GLU A 1287 REMARK 465 LYS A 1288 REMARK 465 MET B 4 REMARK 465 PHE B 5 REMARK 465 VAL B 6 REMARK 465 PHE B 7 REMARK 465 LEU B 8 REMARK 465 VAL B 9 REMARK 465 LEU B 10 REMARK 465 LEU B 11 REMARK 465 PRO B 12 REMARK 465 LEU B 13 REMARK 465 VAL B 14 REMARK 465 SER B 15 REMARK 465 SER B 16 REMARK 465 GLN B 17 REMARK 465 CYS B 18 REMARK 465 HIS B 69 REMARK 465 VAL B 70 REMARK 465 SER B 71 REMARK 465 GLY B 72 REMARK 465 THR B 73 REMARK 465 ASN B 74 REMARK 465 GLY B 75 REMARK 465 THR B 76 REMARK 465 LYS B 77 REMARK 465 ARG B 78 REMARK 465 PHE B 79 REMARK 465 ASP B 80 REMARK 465 ASP B 142 REMARK 465 VAL B 143 REMARK 465 TYR B 144 REMARK 465 TYR B 145 REMARK 465 HIS B 146 REMARK 465 LYS B 147 REMARK 465 ASN B 148 REMARK 465 ASN B 149 REMARK 465 LYS B 150 REMARK 465 SER B 151 REMARK 465 TRP B 152 REMARK 465 MET B 153 REMARK 465 GLU B 154 REMARK 465 SER B 155 REMARK 465 GLU B 156 REMARK 465 PHE B 157 REMARK 465 ARG B 158 REMARK 465 VAL B 159 REMARK 465 TYR B 160 REMARK 465 SER B 161 REMARK 465 SER B 162 REMARK 465 ALA B 163 REMARK 465 ASN B 164 REMARK 465 ASP B 178 REMARK 465 LEU B 179 REMARK 465 GLU B 180 REMARK 465 GLY B 181 REMARK 465 LYS B 182 REMARK 465 GLN B 183 REMARK 465 GLY B 184 REMARK 465 ASN B 185 REMARK 465 PHE B 186 REMARK 465 ASN B 211 REMARK 465 LEU B 212 REMARK 465 GLY B 213 REMARK 465 ARG B 214 REMARK 465 LEU B 244 REMARK 465 HIS B 245 REMARK 465 ARG B 246 REMARK 465 SER B 247 REMARK 465 TYR B 248 REMARK 465 LEU B 249 REMARK 465 THR B 250 REMARK 465 PRO B 251 REMARK 465 GLY B 252 REMARK 465 ASP B 253 REMARK 465 SER B 254 REMARK 465 SER B 255 REMARK 465 SER B 256 REMARK 465 GLY B 257 REMARK 465 TRP B 258 REMARK 465 THR B 259 REMARK 465 ALA B 260 REMARK 465 GLY B 261 REMARK 465 ALA B 262 REMARK 465 GLY B 476 REMARK 465 ASN B 477 REMARK 465 LYS B 478 REMARK 465 ILE B 624 REMARK 465 HIS B 625 REMARK 465 ALA B 626 REMARK 465 ASP B 627 REMARK 465 GLN B 628 REMARK 465 LEU B 629 REMARK 465 THR B 630 REMARK 465 PRO B 631 REMARK 465 THR B 632 REMARK 465 TRP B 633 REMARK 465 ARG B 634 REMARK 465 VAL B 635 REMARK 465 TYR B 636 REMARK 465 SER B 637 REMARK 465 THR B 638 REMARK 465 GLN B 675 REMARK 465 THR B 676 REMARK 465 GLN B 677 REMARK 465 THR B 678 REMARK 465 LYS B 679 REMARK 465 SER B 680 REMARK 465 HIS B 681 REMARK 465 GLY B 682 REMARK 465 SER B 683 REMARK 465 ALA B 684 REMARK 465 SER B 685 REMARK 465 SER B 686 REMARK 465 VAL B 687 REMARK 465 ALA B 688 REMARK 465 SER B 689 REMARK 465 GLN B 690 REMARK 465 PHE B 1148 REMARK 465 LYS B 1149 REMARK 465 GLU B 1150 REMARK 465 GLU B 1151 REMARK 465 LEU B 1152 REMARK 465 ASP B 1153 REMARK 465 LYS B 1154 REMARK 465 TYR B 1155 REMARK 465 PHE B 1156 REMARK 465 LYS B 1157 REMARK 465 ASN B 1158 REMARK 465 HIS B 1159 REMARK 465 THR B 1160 REMARK 465 SER B 1161 REMARK 465 PRO B 1162 REMARK 465 ASP B 1163 REMARK 465 VAL B 1164 REMARK 465 ASP B 1165 REMARK 465 LEU B 1166 REMARK 465 GLY B 1167 REMARK 465 ASP B 1168 REMARK 465 ILE B 1169 REMARK 465 SER B 1170 REMARK 465 GLY B 1171 REMARK 465 ILE B 1172 REMARK 465 ASN B 1173 REMARK 465 ALA B 1174 REMARK 465 SER B 1175 REMARK 465 VAL B 1176 REMARK 465 VAL B 1177 REMARK 465 ASN B 1178 REMARK 465 ILE B 1179 REMARK 465 GLN B 1180 REMARK 465 LYS B 1181 REMARK 465 GLU B 1182 REMARK 465 ILE B 1183 REMARK 465 ASP B 1184 REMARK 465 ARG B 1185 REMARK 465 LEU B 1186 REMARK 465 ASN B 1187 REMARK 465 GLU B 1188 REMARK 465 VAL B 1189 REMARK 465 ALA B 1190 REMARK 465 LYS B 1191 REMARK 465 ASN B 1192 REMARK 465 LEU B 1193 REMARK 465 ASN B 1194 REMARK 465 GLU B 1195 REMARK 465 SER B 1196 REMARK 465 LEU B 1197 REMARK 465 ILE B 1198 REMARK 465 ASP B 1199 REMARK 465 LEU B 1200 REMARK 465 GLN B 1201 REMARK 465 GLU B 1202 REMARK 465 LEU B 1203 REMARK 465 GLY B 1204 REMARK 465 LYS B 1205 REMARK 465 TYR B 1206 REMARK 465 GLU B 1207 REMARK 465 GLN B 1208 REMARK 465 GLY B 1209 REMARK 465 SER B 1210 REMARK 465 GLY B 1211 REMARK 465 TYR B 1212 REMARK 465 ILE B 1213 REMARK 465 PRO B 1214 REMARK 465 GLU B 1215 REMARK 465 ALA B 1216 REMARK 465 PRO B 1217 REMARK 465 ARG B 1218 REMARK 465 ASP B 1219 REMARK 465 GLY B 1220 REMARK 465 GLN B 1221 REMARK 465 ALA B 1222 REMARK 465 TYR B 1223 REMARK 465 VAL B 1224 REMARK 465 ARG B 1225 REMARK 465 LYS B 1226 REMARK 465 ASP B 1227 REMARK 465 GLY B 1228 REMARK 465 GLU B 1229 REMARK 465 TRP B 1230 REMARK 465 VAL B 1231 REMARK 465 LEU B 1232 REMARK 465 LEU B 1233 REMARK 465 SER B 1234 REMARK 465 THR B 1235 REMARK 465 PHE B 1236 REMARK 465 LEU B 1237 REMARK 465 GLY B 1238 REMARK 465 ARG B 1239 REMARK 465 SER B 1240 REMARK 465 LEU B 1241 REMARK 465 GLU B 1242 REMARK 465 VAL B 1243 REMARK 465 LEU B 1244 REMARK 465 PHE B 1245 REMARK 465 GLN B 1246 REMARK 465 GLY B 1247 REMARK 465 PRO B 1248 REMARK 465 GLY B 1249 REMARK 465 HIS B 1250 REMARK 465 HIS B 1251 REMARK 465 HIS B 1252 REMARK 465 HIS B 1253 REMARK 465 HIS B 1254 REMARK 465 HIS B 1255 REMARK 465 HIS B 1256 REMARK 465 HIS B 1257 REMARK 465 SER B 1258 REMARK 465 ALA B 1259 REMARK 465 TRP B 1260 REMARK 465 SER B 1261 REMARK 465 HIS B 1262 REMARK 465 PRO B 1263 REMARK 465 GLN B 1264 REMARK 465 PHE B 1265 REMARK 465 GLU B 1266 REMARK 465 LYS B 1267 REMARK 465 GLY B 1268 REMARK 465 GLY B 1269 REMARK 465 GLY B 1270 REMARK 465 SER B 1271 REMARK 465 GLY B 1272 REMARK 465 GLY B 1273 REMARK 465 GLY B 1274 REMARK 465 GLY B 1275 REMARK 465 SER B 1276 REMARK 465 GLY B 1277 REMARK 465 GLY B 1278 REMARK 465 SER B 1279 REMARK 465 ALA B 1280 REMARK 465 TRP B 1281 REMARK 465 SER B 1282 REMARK 465 HIS B 1283 REMARK 465 PRO B 1284 REMARK 465 GLN B 1285 REMARK 465 PHE B 1286 REMARK 465 GLU B 1287 REMARK 465 LYS B 1288 REMARK 465 MET C 4 REMARK 465 PHE C 5 REMARK 465 VAL C 6 REMARK 465 PHE C 7 REMARK 465 LEU C 8 REMARK 465 VAL C 9 REMARK 465 LEU C 10 REMARK 465 LEU C 11 REMARK 465 PRO C 12 REMARK 465 LEU C 13 REMARK 465 VAL C 14 REMARK 465 SER C 15 REMARK 465 SER C 16 REMARK 465 GLN C 17 REMARK 465 CYS C 18 REMARK 465 VAL C 19 REMARK 465 ASN C 20 REMARK 465 LEU C 21 REMARK 465 ILE C 22 REMARK 465 THR C 23 REMARK 465 SER C 71 REMARK 465 GLY C 72 REMARK 465 THR C 73 REMARK 465 ASN C 74 REMARK 465 GLY C 75 REMARK 465 THR C 76 REMARK 465 LYS C 77 REMARK 465 ARG C 78 REMARK 465 PHE C 79 REMARK 465 ASP C 80 REMARK 465 ASN C 137 REMARK 465 ASP C 138 REMARK 465 PRO C 139 REMARK 465 PHE C 140 REMARK 465 LEU C 141 REMARK 465 ASP C 142 REMARK 465 VAL C 143 REMARK 465 TYR C 144 REMARK 465 TYR C 145 REMARK 465 HIS C 146 REMARK 465 LYS C 147 REMARK 465 ASN C 148 REMARK 465 ASN C 149 REMARK 465 LYS C 150 REMARK 465 SER C 151 REMARK 465 TRP C 152 REMARK 465 MET C 153 REMARK 465 GLU C 154 REMARK 465 SER C 155 REMARK 465 GLU C 156 REMARK 465 PHE C 157 REMARK 465 ARG C 158 REMARK 465 VAL C 159 REMARK 465 TYR C 160 REMARK 465 SER C 161 REMARK 465 SER C 162 REMARK 465 ALA C 163 REMARK 465 ASN C 164 REMARK 465 GLU C 180 REMARK 465 GLY C 181 REMARK 465 LYS C 182 REMARK 465 GLN C 183 REMARK 465 GLY C 184 REMARK 465 ASN C 185 REMARK 465 LEU C 212 REMARK 465 GLY C 213 REMARK 465 ARG C 214 REMARK 465 LEU C 244 REMARK 465 HIS C 245 REMARK 465 ARG C 246 REMARK 465 SER C 247 REMARK 465 TYR C 248 REMARK 465 LEU C 249 REMARK 465 THR C 250 REMARK 465 PRO C 251 REMARK 465 GLY C 252 REMARK 465 ASP C 253 REMARK 465 SER C 254 REMARK 465 SER C 255 REMARK 465 SER C 256 REMARK 465 GLY C 257 REMARK 465 TRP C 258 REMARK 465 THR C 259 REMARK 465 ALA C 260 REMARK 465 ALA C 623 REMARK 465 ILE C 624 REMARK 465 HIS C 625 REMARK 465 ALA C 626 REMARK 465 ASP C 627 REMARK 465 GLN C 628 REMARK 465 LEU C 629 REMARK 465 THR C 630 REMARK 465 PRO C 631 REMARK 465 THR C 632 REMARK 465 TRP C 633 REMARK 465 ARG C 634 REMARK 465 VAL C 635 REMARK 465 TYR C 636 REMARK 465 SER C 637 REMARK 465 LYS C 679 REMARK 465 SER C 680 REMARK 465 HIS C 681 REMARK 465 GLY C 682 REMARK 465 SER C 683 REMARK 465 ALA C 684 REMARK 465 SER C 685 REMARK 465 SER C 686 REMARK 465 VAL C 687 REMARK 465 ALA C 688 REMARK 465 PHE C 1148 REMARK 465 LYS C 1149 REMARK 465 GLU C 1150 REMARK 465 GLU C 1151 REMARK 465 LEU C 1152 REMARK 465 ASP C 1153 REMARK 465 LYS C 1154 REMARK 465 TYR C 1155 REMARK 465 PHE C 1156 REMARK 465 LYS C 1157 REMARK 465 ASN C 1158 REMARK 465 HIS C 1159 REMARK 465 THR C 1160 REMARK 465 SER C 1161 REMARK 465 PRO C 1162 REMARK 465 ASP C 1163 REMARK 465 VAL C 1164 REMARK 465 ASP C 1165 REMARK 465 LEU C 1166 REMARK 465 GLY C 1167 REMARK 465 ASP C 1168 REMARK 465 ILE C 1169 REMARK 465 SER C 1170 REMARK 465 GLY C 1171 REMARK 465 ILE C 1172 REMARK 465 ASN C 1173 REMARK 465 ALA C 1174 REMARK 465 SER C 1175 REMARK 465 VAL C 1176 REMARK 465 VAL C 1177 REMARK 465 ASN C 1178 REMARK 465 ILE C 1179 REMARK 465 GLN C 1180 REMARK 465 LYS C 1181 REMARK 465 GLU C 1182 REMARK 465 ILE C 1183 REMARK 465 ASP C 1184 REMARK 465 ARG C 1185 REMARK 465 LEU C 1186 REMARK 465 ASN C 1187 REMARK 465 GLU C 1188 REMARK 465 VAL C 1189 REMARK 465 ALA C 1190 REMARK 465 LYS C 1191 REMARK 465 ASN C 1192 REMARK 465 LEU C 1193 REMARK 465 ASN C 1194 REMARK 465 GLU C 1195 REMARK 465 SER C 1196 REMARK 465 LEU C 1197 REMARK 465 ILE C 1198 REMARK 465 ASP C 1199 REMARK 465 LEU C 1200 REMARK 465 GLN C 1201 REMARK 465 GLU C 1202 REMARK 465 LEU C 1203 REMARK 465 GLY C 1204 REMARK 465 LYS C 1205 REMARK 465 TYR C 1206 REMARK 465 GLU C 1207 REMARK 465 GLN C 1208 REMARK 465 GLY C 1209 REMARK 465 SER C 1210 REMARK 465 GLY C 1211 REMARK 465 TYR C 1212 REMARK 465 ILE C 1213 REMARK 465 PRO C 1214 REMARK 465 GLU C 1215 REMARK 465 ALA C 1216 REMARK 465 PRO C 1217 REMARK 465 ARG C 1218 REMARK 465 ASP C 1219 REMARK 465 GLY C 1220 REMARK 465 GLN C 1221 REMARK 465 ALA C 1222 REMARK 465 TYR C 1223 REMARK 465 VAL C 1224 REMARK 465 ARG C 1225 REMARK 465 LYS C 1226 REMARK 465 ASP C 1227 REMARK 465 GLY C 1228 REMARK 465 GLU C 1229 REMARK 465 TRP C 1230 REMARK 465 VAL C 1231 REMARK 465 LEU C 1232 REMARK 465 LEU C 1233 REMARK 465 SER C 1234 REMARK 465 THR C 1235 REMARK 465 PHE C 1236 REMARK 465 LEU C 1237 REMARK 465 GLY C 1238 REMARK 465 ARG C 1239 REMARK 465 SER C 1240 REMARK 465 LEU C 1241 REMARK 465 GLU C 1242 REMARK 465 VAL C 1243 REMARK 465 LEU C 1244 REMARK 465 PHE C 1245 REMARK 465 GLN C 1246 REMARK 465 GLY C 1247 REMARK 465 PRO C 1248 REMARK 465 GLY C 1249 REMARK 465 HIS C 1250 REMARK 465 HIS C 1251 REMARK 465 HIS C 1252 REMARK 465 HIS C 1253 REMARK 465 HIS C 1254 REMARK 465 HIS C 1255 REMARK 465 HIS C 1256 REMARK 465 HIS C 1257 REMARK 465 SER C 1258 REMARK 465 ALA C 1259 REMARK 465 TRP C 1260 REMARK 465 SER C 1261 REMARK 465 HIS C 1262 REMARK 465 PRO C 1263 REMARK 465 GLN C 1264 REMARK 465 PHE C 1265 REMARK 465 GLU C 1266 REMARK 465 LYS C 1267 REMARK 465 GLY C 1268 REMARK 465 GLY C 1269 REMARK 465 GLY C 1270 REMARK 465 SER C 1271 REMARK 465 GLY C 1272 REMARK 465 GLY C 1273 REMARK 465 GLY C 1274 REMARK 465 GLY C 1275 REMARK 465 SER C 1276 REMARK 465 GLY C 1277 REMARK 465 GLY C 1278 REMARK 465 SER C 1279 REMARK 465 ALA C 1280 REMARK 465 TRP C 1281 REMARK 465 SER C 1282 REMARK 465 HIS C 1283 REMARK 465 PRO C 1284 REMARK 465 GLN C 1285 REMARK 465 PHE C 1286 REMARK 465 GLU C 1287 REMARK 465 LYS C 1288 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 LYS A 41 32.98 -96.49 REMARK 500 ASP A 88 -97.16 54.67 REMARK 500 ASP A 111 -168.63 -125.99 REMARK 500 ASP A 138 73.34 52.37 REMARK 500 ASN A 343 59.07 -93.59 REMARK 500 ASN A 556 32.80 -96.91 REMARK 500 ASN A 710 20.49 -142.82 REMARK 500 VAL A 729 -54.39 -123.03 REMARK 500 ASP A 745 53.11 -92.82 REMARK 500 PHE A 797 57.84 -96.94 REMARK 500 GLN A 836 16.70 -142.75 REMARK 500 TRP A 886 15.79 54.37 REMARK 500 LEU A 945 30.30 -92.58 REMARK 500 PHE B 32 -132.19 58.56 REMARK 500 LYS B 41 56.76 -92.30 REMARK 500 ASP B 88 60.14 60.62 REMARK 500 ALA B 123 -135.77 59.14 REMARK 500 THR B 167 11.53 -141.29 REMARK 500 ALA B 292 34.25 -98.77 REMARK 500 LEU B 293 -60.51 -94.86 REMARK 500 ILE B 666 -61.19 -121.96 REMARK 500 VAL B 729 -52.47 -124.49 REMARK 500 ASP B 745 61.84 60.70 REMARK 500 LEU B 849 -10.00 73.52 REMARK 500 GLU B1144 59.47 -95.54 REMARK 500 LYS C 41 56.16 -93.88 REMARK 500 ASN C 121 77.45 -103.66 REMARK 500 ASP C 389 -85.56 -86.11 REMARK 500 PHE C 392 -165.80 -101.32 REMARK 500 THR C 393 -64.21 -100.97 REMARK 500 ASP C 428 59.40 -91.09 REMARK 500 ASN C 481 42.38 39.69 REMARK 500 ALA C 522 83.57 -67.98 REMARK 500 ASN C 710 26.01 -140.75 REMARK 500 VAL C 729 -52.05 -124.58 REMARK 500 MET C 731 -167.52 -126.43 REMARK 500 TYR C 837 -1.40 65.31 REMARK 500 ALA C 846 -143.64 59.63 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-26436 RELATED DB: EMDB REMARK 900 SARS-COV-2 OMICRON-BA.2 3-RBD DOWN SPIKE PROTEIN TRIMER WITHOUT THE REMARK 900 P986-P987 STABILIZING MUTATIONS (S-GSAS-OMICRON-BA.2) DBREF 7UB6 A 4 1208 UNP P0DTC2 SPIKE_SARS2 1 1208 DBREF 7UB6 B 4 1208 UNP P0DTC2 SPIKE_SARS2 1 1208 DBREF 7UB6 C 4 1208 UNP P0DTC2 SPIKE_SARS2 1 1208 SEQADV 7UB6 ILE A 22 UNP P0DTC2 THR 19 CONFLICT SEQADV 7UB6 A UNP P0DTC2 LEU 24 DELETION SEQADV 7UB6 A UNP P0DTC2 PRO 25 DELETION SEQADV 7UB6 A UNP P0DTC2 PRO 26 DELETION SEQADV 7UB6 SER A 27 UNP P0DTC2 ALA 27 CONFLICT SEQADV 7UB6 ASP A 142 UNP P0DTC2 GLY 142 VARIANT SEQADV 7UB6 GLY A 213 UNP P0DTC2 VAL 213 CONFLICT SEQADV 7UB6 ASP A 339 UNP P0DTC2 GLY 339 VARIANT SEQADV 7UB6 PHE A 371 UNP P0DTC2 SER 371 CONFLICT SEQADV 7UB6 PRO A 373 UNP P0DTC2 SER 373 VARIANT SEQADV 7UB6 PHE A 375 UNP P0DTC2 SER 375 VARIANT SEQADV 7UB6 ALA A 376 UNP P0DTC2 THR 376 CONFLICT SEQADV 7UB6 ASN A 405 UNP P0DTC2 ASP 405 CONFLICT SEQADV 7UB6 SER A 408 UNP P0DTC2 ARG 408 CONFLICT SEQADV 7UB6 ASN A 417 UNP P0DTC2 LYS 417 VARIANT SEQADV 7UB6 LYS A 440 UNP P0DTC2 ASN 440 VARIANT SEQADV 7UB6 ASN A 477 UNP P0DTC2 SER 477 VARIANT SEQADV 7UB6 LYS A 478 UNP P0DTC2 THR 478 VARIANT SEQADV 7UB6 ALA A 484 UNP P0DTC2 GLU 484 VARIANT SEQADV 7UB6 ARG A 493 UNP P0DTC2 GLN 493 VARIANT SEQADV 7UB6 ARG A 498 UNP P0DTC2 GLN 498 CONFLICT SEQADV 7UB6 TYR A 501 UNP P0DTC2 ASN 501 VARIANT SEQADV 7UB6 HIS A 505 UNP P0DTC2 TYR 505 VARIANT SEQADV 7UB6 GLY A 614 UNP P0DTC2 ASP 614 VARIANT SEQADV 7UB6 TYR A 655 UNP P0DTC2 HIS 655 VARIANT SEQADV 7UB6 LYS A 679 UNP P0DTC2 ASN 679 VARIANT SEQADV 7UB6 HIS A 681 UNP P0DTC2 PRO 681 VARIANT SEQADV 7UB6 GLY A 682 UNP P0DTC2 ARG 682 ENGINEERED MUTATION SEQADV 7UB6 SER A 683 UNP P0DTC2 ARG 683 ENGINEERED MUTATION SEQADV 7UB6 SER A 685 UNP P0DTC2 ARG 685 ENGINEERED MUTATION SEQADV 7UB6 LYS A 764 UNP P0DTC2 ASN 764 VARIANT SEQADV 7UB6 TYR A 796 UNP P0DTC2 ASP 796 VARIANT SEQADV 7UB6 HIS A 954 UNP P0DTC2 GLN 954 VARIANT SEQADV 7UB6 LYS A 969 UNP P0DTC2 ASN 969 VARIANT SEQADV 7UB6 GLY A 1209 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 SER A 1210 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY A 1211 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 TYR A 1212 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ILE A 1213 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 PRO A 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLU A 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ALA A 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 PRO A 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ARG A 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ASP A 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY A 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLN A 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ALA A 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 TYR A 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 VAL A 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ARG A 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 LYS A 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ASP A 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY A 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLU A 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 TRP A 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 VAL A 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 LEU A 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 LEU A 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 SER A 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 THR A 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 PHE A 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 LEU A 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY A 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ARG A 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 SER A 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 LEU A 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLU A 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 VAL A 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 LEU A 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 PHE A 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLN A 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY A 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 PRO A 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY A 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS A 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS A 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS A 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS A 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS A 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS A 1255 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS A 1256 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS A 1257 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 SER A 1258 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ALA A 1259 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 TRP A 1260 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 SER A 1261 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS A 1262 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 PRO A 1263 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLN A 1264 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 PHE A 1265 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLU A 1266 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 LYS A 1267 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY A 1268 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY A 1269 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY A 1270 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 SER A 1271 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY A 1272 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY A 1273 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY A 1274 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY A 1275 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 SER A 1276 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY A 1277 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY A 1278 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 SER A 1279 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ALA A 1280 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 TRP A 1281 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 SER A 1282 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS A 1283 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 PRO A 1284 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLN A 1285 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 PHE A 1286 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLU A 1287 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 LYS A 1288 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ILE B 22 UNP P0DTC2 THR 19 CONFLICT SEQADV 7UB6 B UNP P0DTC2 LEU 24 DELETION SEQADV 7UB6 B UNP P0DTC2 PRO 25 DELETION SEQADV 7UB6 B UNP P0DTC2 PRO 26 DELETION SEQADV 7UB6 SER B 27 UNP P0DTC2 ALA 27 CONFLICT SEQADV 7UB6 ASP B 142 UNP P0DTC2 GLY 142 VARIANT SEQADV 7UB6 GLY B 213 UNP P0DTC2 VAL 213 CONFLICT SEQADV 7UB6 ASP B 339 UNP P0DTC2 GLY 339 VARIANT SEQADV 7UB6 PHE B 371 UNP P0DTC2 SER 371 CONFLICT SEQADV 7UB6 PRO B 373 UNP P0DTC2 SER 373 VARIANT SEQADV 7UB6 PHE B 375 UNP P0DTC2 SER 375 VARIANT SEQADV 7UB6 ALA B 376 UNP P0DTC2 THR 376 CONFLICT SEQADV 7UB6 ASN B 405 UNP P0DTC2 ASP 405 CONFLICT SEQADV 7UB6 SER B 408 UNP P0DTC2 ARG 408 CONFLICT SEQADV 7UB6 ASN B 417 UNP P0DTC2 LYS 417 VARIANT SEQADV 7UB6 LYS B 440 UNP P0DTC2 ASN 440 VARIANT SEQADV 7UB6 ASN B 477 UNP P0DTC2 SER 477 VARIANT SEQADV 7UB6 LYS B 478 UNP P0DTC2 THR 478 VARIANT SEQADV 7UB6 ALA B 484 UNP P0DTC2 GLU 484 VARIANT SEQADV 7UB6 ARG B 493 UNP P0DTC2 GLN 493 VARIANT SEQADV 7UB6 ARG B 498 UNP P0DTC2 GLN 498 CONFLICT SEQADV 7UB6 TYR B 501 UNP P0DTC2 ASN 501 VARIANT SEQADV 7UB6 HIS B 505 UNP P0DTC2 TYR 505 VARIANT SEQADV 7UB6 GLY B 614 UNP P0DTC2 ASP 614 VARIANT SEQADV 7UB6 TYR B 655 UNP P0DTC2 HIS 655 VARIANT SEQADV 7UB6 LYS B 679 UNP P0DTC2 ASN 679 VARIANT SEQADV 7UB6 HIS B 681 UNP P0DTC2 PRO 681 VARIANT SEQADV 7UB6 GLY B 682 UNP P0DTC2 ARG 682 ENGINEERED MUTATION SEQADV 7UB6 SER B 683 UNP P0DTC2 ARG 683 ENGINEERED MUTATION SEQADV 7UB6 SER B 685 UNP P0DTC2 ARG 685 ENGINEERED MUTATION SEQADV 7UB6 LYS B 764 UNP P0DTC2 ASN 764 VARIANT SEQADV 7UB6 TYR B 796 UNP P0DTC2 ASP 796 VARIANT SEQADV 7UB6 HIS B 954 UNP P0DTC2 GLN 954 VARIANT SEQADV 7UB6 LYS B 969 UNP P0DTC2 ASN 969 VARIANT SEQADV 7UB6 GLY B 1209 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 SER B 1210 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY B 1211 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 TYR B 1212 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ILE B 1213 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 PRO B 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLU B 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ALA B 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 PRO B 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ARG B 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ASP B 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY B 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLN B 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ALA B 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 TYR B 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 VAL B 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ARG B 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 LYS B 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ASP B 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY B 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLU B 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 TRP B 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 VAL B 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 LEU B 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 LEU B 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 SER B 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 THR B 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 PHE B 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 LEU B 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY B 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ARG B 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 SER B 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 LEU B 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLU B 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 VAL B 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 LEU B 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 PHE B 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLN B 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY B 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 PRO B 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY B 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS B 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS B 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS B 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS B 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS B 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS B 1255 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS B 1256 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS B 1257 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 SER B 1258 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ALA B 1259 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 TRP B 1260 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 SER B 1261 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS B 1262 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 PRO B 1263 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLN B 1264 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 PHE B 1265 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLU B 1266 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 LYS B 1267 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY B 1268 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY B 1269 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY B 1270 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 SER B 1271 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY B 1272 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY B 1273 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY B 1274 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY B 1275 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 SER B 1276 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY B 1277 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY B 1278 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 SER B 1279 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ALA B 1280 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 TRP B 1281 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 SER B 1282 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS B 1283 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 PRO B 1284 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLN B 1285 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 PHE B 1286 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLU B 1287 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 LYS B 1288 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ILE C 22 UNP P0DTC2 THR 19 CONFLICT SEQADV 7UB6 C UNP P0DTC2 LEU 24 DELETION SEQADV 7UB6 C UNP P0DTC2 PRO 25 DELETION SEQADV 7UB6 C UNP P0DTC2 PRO 26 DELETION SEQADV 7UB6 SER C 27 UNP P0DTC2 ALA 27 CONFLICT SEQADV 7UB6 ASP C 142 UNP P0DTC2 GLY 142 VARIANT SEQADV 7UB6 GLY C 213 UNP P0DTC2 VAL 213 CONFLICT SEQADV 7UB6 ASP C 339 UNP P0DTC2 GLY 339 VARIANT SEQADV 7UB6 PHE C 371 UNP P0DTC2 SER 371 CONFLICT SEQADV 7UB6 PRO C 373 UNP P0DTC2 SER 373 VARIANT SEQADV 7UB6 PHE C 375 UNP P0DTC2 SER 375 VARIANT SEQADV 7UB6 ALA C 376 UNP P0DTC2 THR 376 CONFLICT SEQADV 7UB6 ASN C 405 UNP P0DTC2 ASP 405 CONFLICT SEQADV 7UB6 SER C 408 UNP P0DTC2 ARG 408 CONFLICT SEQADV 7UB6 ASN C 417 UNP P0DTC2 LYS 417 VARIANT SEQADV 7UB6 LYS C 440 UNP P0DTC2 ASN 440 VARIANT SEQADV 7UB6 ASN C 477 UNP P0DTC2 SER 477 VARIANT SEQADV 7UB6 LYS C 478 UNP P0DTC2 THR 478 VARIANT SEQADV 7UB6 ALA C 484 UNP P0DTC2 GLU 484 VARIANT SEQADV 7UB6 ARG C 493 UNP P0DTC2 GLN 493 VARIANT SEQADV 7UB6 ARG C 498 UNP P0DTC2 GLN 498 CONFLICT SEQADV 7UB6 TYR C 501 UNP P0DTC2 ASN 501 VARIANT SEQADV 7UB6 HIS C 505 UNP P0DTC2 TYR 505 VARIANT SEQADV 7UB6 GLY C 614 UNP P0DTC2 ASP 614 VARIANT SEQADV 7UB6 TYR C 655 UNP P0DTC2 HIS 655 VARIANT SEQADV 7UB6 LYS C 679 UNP P0DTC2 ASN 679 VARIANT SEQADV 7UB6 HIS C 681 UNP P0DTC2 PRO 681 VARIANT SEQADV 7UB6 GLY C 682 UNP P0DTC2 ARG 682 ENGINEERED MUTATION SEQADV 7UB6 SER C 683 UNP P0DTC2 ARG 683 ENGINEERED MUTATION SEQADV 7UB6 SER C 685 UNP P0DTC2 ARG 685 ENGINEERED MUTATION SEQADV 7UB6 LYS C 764 UNP P0DTC2 ASN 764 VARIANT SEQADV 7UB6 TYR C 796 UNP P0DTC2 ASP 796 VARIANT SEQADV 7UB6 HIS C 954 UNP P0DTC2 GLN 954 VARIANT SEQADV 7UB6 LYS C 969 UNP P0DTC2 ASN 969 VARIANT SEQADV 7UB6 GLY C 1209 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 SER C 1210 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY C 1211 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 TYR C 1212 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ILE C 1213 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 PRO C 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLU C 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ALA C 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 PRO C 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ARG C 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ASP C 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY C 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLN C 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ALA C 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 TYR C 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 VAL C 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ARG C 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 LYS C 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ASP C 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY C 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLU C 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 TRP C 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 VAL C 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 LEU C 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 LEU C 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 SER C 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 THR C 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 PHE C 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 LEU C 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY C 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ARG C 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 SER C 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 LEU C 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLU C 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 VAL C 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 LEU C 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 PHE C 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLN C 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY C 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 PRO C 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY C 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS C 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS C 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS C 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS C 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS C 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS C 1255 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS C 1256 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS C 1257 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 SER C 1258 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ALA C 1259 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 TRP C 1260 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 SER C 1261 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS C 1262 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 PRO C 1263 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLN C 1264 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 PHE C 1265 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLU C 1266 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 LYS C 1267 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY C 1268 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY C 1269 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY C 1270 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 SER C 1271 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY C 1272 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY C 1273 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY C 1274 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY C 1275 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 SER C 1276 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY C 1277 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLY C 1278 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 SER C 1279 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 ALA C 1280 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 TRP C 1281 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 SER C 1282 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 HIS C 1283 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 PRO C 1284 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLN C 1285 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 PHE C 1286 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 GLU C 1287 UNP P0DTC2 EXPRESSION TAG SEQADV 7UB6 LYS C 1288 UNP P0DTC2 EXPRESSION TAG SEQRES 1 A 1285 MET PHE VAL PHE LEU VAL LEU LEU PRO LEU VAL SER SER SEQRES 2 A 1285 GLN CYS VAL ASN LEU ILE THR ARG THR GLN SER TYR THR SEQRES 3 A 1285 ASN SER PHE THR ARG GLY VAL TYR TYR PRO ASP LYS VAL SEQRES 4 A 1285 PHE ARG SER SER VAL LEU HIS SER THR GLN ASP LEU PHE SEQRES 5 A 1285 LEU PRO PHE PHE SER ASN VAL THR TRP PHE HIS ALA ILE SEQRES 6 A 1285 HIS VAL SER GLY THR ASN GLY THR LYS ARG PHE ASP ASN SEQRES 7 A 1285 PRO VAL LEU PRO PHE ASN ASP GLY VAL TYR PHE ALA SER SEQRES 8 A 1285 THR GLU LYS SER ASN ILE ILE ARG GLY TRP ILE PHE GLY SEQRES 9 A 1285 THR THR LEU ASP SER LYS THR GLN SER LEU LEU ILE VAL SEQRES 10 A 1285 ASN ASN ALA THR ASN VAL VAL ILE LYS VAL CYS GLU PHE SEQRES 11 A 1285 GLN PHE CYS ASN ASP PRO PHE LEU ASP VAL TYR TYR HIS SEQRES 12 A 1285 LYS ASN ASN LYS SER TRP MET GLU SER GLU PHE ARG VAL SEQRES 13 A 1285 TYR SER SER ALA ASN ASN CYS THR PHE GLU TYR VAL SER SEQRES 14 A 1285 GLN PRO PHE LEU MET ASP LEU GLU GLY LYS GLN GLY ASN SEQRES 15 A 1285 PHE LYS ASN LEU ARG GLU PHE VAL PHE LYS ASN ILE ASP SEQRES 16 A 1285 GLY TYR PHE LYS ILE TYR SER LYS HIS THR PRO ILE ASN SEQRES 17 A 1285 LEU GLY ARG ASP LEU PRO GLN GLY PHE SER ALA LEU GLU SEQRES 18 A 1285 PRO LEU VAL ASP LEU PRO ILE GLY ILE ASN ILE THR ARG SEQRES 19 A 1285 PHE GLN THR LEU LEU ALA LEU HIS ARG SER TYR LEU THR SEQRES 20 A 1285 PRO GLY ASP SER SER SER GLY TRP THR ALA GLY ALA ALA SEQRES 21 A 1285 ALA TYR TYR VAL GLY TYR LEU GLN PRO ARG THR PHE LEU SEQRES 22 A 1285 LEU LYS TYR ASN GLU ASN GLY THR ILE THR ASP ALA VAL SEQRES 23 A 1285 ASP CYS ALA LEU ASP PRO LEU SER GLU THR LYS CYS THR SEQRES 24 A 1285 LEU LYS SER PHE THR VAL GLU LYS GLY ILE TYR GLN THR SEQRES 25 A 1285 SER ASN PHE ARG VAL GLN PRO THR GLU SER ILE VAL ARG SEQRES 26 A 1285 PHE PRO ASN ILE THR ASN LEU CYS PRO PHE ASP GLU VAL SEQRES 27 A 1285 PHE ASN ALA THR ARG PHE ALA SER VAL TYR ALA TRP ASN SEQRES 28 A 1285 ARG LYS ARG ILE SER ASN CYS VAL ALA ASP TYR SER VAL SEQRES 29 A 1285 LEU TYR ASN PHE ALA PRO PHE PHE ALA PHE LYS CYS TYR SEQRES 30 A 1285 GLY VAL SER PRO THR LYS LEU ASN ASP LEU CYS PHE THR SEQRES 31 A 1285 ASN VAL TYR ALA ASP SER PHE VAL ILE ARG GLY ASN GLU SEQRES 32 A 1285 VAL SER GLN ILE ALA PRO GLY GLN THR GLY ASN ILE ALA SEQRES 33 A 1285 ASP TYR ASN TYR LYS LEU PRO ASP ASP PHE THR GLY CYS SEQRES 34 A 1285 VAL ILE ALA TRP ASN SER ASN LYS LEU ASP SER LYS VAL SEQRES 35 A 1285 GLY GLY ASN TYR ASN TYR LEU TYR ARG LEU PHE ARG LYS SEQRES 36 A 1285 SER ASN LEU LYS PRO PHE GLU ARG ASP ILE SER THR GLU SEQRES 37 A 1285 ILE TYR GLN ALA GLY ASN LYS PRO CYS ASN GLY VAL ALA SEQRES 38 A 1285 GLY PHE ASN CYS TYR PHE PRO LEU ARG SER TYR GLY PHE SEQRES 39 A 1285 ARG PRO THR TYR GLY VAL GLY HIS GLN PRO TYR ARG VAL SEQRES 40 A 1285 VAL VAL LEU SER PHE GLU LEU LEU HIS ALA PRO ALA THR SEQRES 41 A 1285 VAL CYS GLY PRO LYS LYS SER THR ASN LEU VAL LYS ASN SEQRES 42 A 1285 LYS CYS VAL ASN PHE ASN PHE ASN GLY LEU THR GLY THR SEQRES 43 A 1285 GLY VAL LEU THR GLU SER ASN LYS LYS PHE LEU PRO PHE SEQRES 44 A 1285 GLN GLN PHE GLY ARG ASP ILE ALA ASP THR THR ASP ALA SEQRES 45 A 1285 VAL ARG ASP PRO GLN THR LEU GLU ILE LEU ASP ILE THR SEQRES 46 A 1285 PRO CYS SER PHE GLY GLY VAL SER VAL ILE THR PRO GLY SEQRES 47 A 1285 THR ASN THR SER ASN GLN VAL ALA VAL LEU TYR GLN GLY SEQRES 48 A 1285 VAL ASN CYS THR GLU VAL PRO VAL ALA ILE HIS ALA ASP SEQRES 49 A 1285 GLN LEU THR PRO THR TRP ARG VAL TYR SER THR GLY SER SEQRES 50 A 1285 ASN VAL PHE GLN THR ARG ALA GLY CYS LEU ILE GLY ALA SEQRES 51 A 1285 GLU TYR VAL ASN ASN SER TYR GLU CYS ASP ILE PRO ILE SEQRES 52 A 1285 GLY ALA GLY ILE CYS ALA SER TYR GLN THR GLN THR LYS SEQRES 53 A 1285 SER HIS GLY SER ALA SER SER VAL ALA SER GLN SER ILE SEQRES 54 A 1285 ILE ALA TYR THR MET SER LEU GLY ALA GLU ASN SER VAL SEQRES 55 A 1285 ALA TYR SER ASN ASN SER ILE ALA ILE PRO THR ASN PHE SEQRES 56 A 1285 THR ILE SER VAL THR THR GLU ILE LEU PRO VAL SER MET SEQRES 57 A 1285 THR LYS THR SER VAL ASP CYS THR MET TYR ILE CYS GLY SEQRES 58 A 1285 ASP SER THR GLU CYS SER ASN LEU LEU LEU GLN TYR GLY SEQRES 59 A 1285 SER PHE CYS THR GLN LEU LYS ARG ALA LEU THR GLY ILE SEQRES 60 A 1285 ALA VAL GLU GLN ASP LYS ASN THR GLN GLU VAL PHE ALA SEQRES 61 A 1285 GLN VAL LYS GLN ILE TYR LYS THR PRO PRO ILE LYS TYR SEQRES 62 A 1285 PHE GLY GLY PHE ASN PHE SER GLN ILE LEU PRO ASP PRO SEQRES 63 A 1285 SER LYS PRO SER LYS ARG SER PHE ILE GLU ASP LEU LEU SEQRES 64 A 1285 PHE ASN LYS VAL THR LEU ALA ASP ALA GLY PHE ILE LYS SEQRES 65 A 1285 GLN TYR GLY ASP CYS LEU GLY ASP ILE ALA ALA ARG ASP SEQRES 66 A 1285 LEU ILE CYS ALA GLN LYS PHE ASN GLY LEU THR VAL LEU SEQRES 67 A 1285 PRO PRO LEU LEU THR ASP GLU MET ILE ALA GLN TYR THR SEQRES 68 A 1285 SER ALA LEU LEU ALA GLY THR ILE THR SER GLY TRP THR SEQRES 69 A 1285 PHE GLY ALA GLY ALA ALA LEU GLN ILE PRO PHE ALA MET SEQRES 70 A 1285 GLN MET ALA TYR ARG PHE ASN GLY ILE GLY VAL THR GLN SEQRES 71 A 1285 ASN VAL LEU TYR GLU ASN GLN LYS LEU ILE ALA ASN GLN SEQRES 72 A 1285 PHE ASN SER ALA ILE GLY LYS ILE GLN ASP SER LEU SER SEQRES 73 A 1285 SER THR ALA SER ALA LEU GLY LYS LEU GLN ASP VAL VAL SEQRES 74 A 1285 ASN HIS ASN ALA GLN ALA LEU ASN THR LEU VAL LYS GLN SEQRES 75 A 1285 LEU SER SER LYS PHE GLY ALA ILE SER SER VAL LEU ASN SEQRES 76 A 1285 ASP ILE LEU SER ARG LEU ASP LYS VAL GLU ALA GLU VAL SEQRES 77 A 1285 GLN ILE ASP ARG LEU ILE THR GLY ARG LEU GLN SER LEU SEQRES 78 A 1285 GLN THR TYR VAL THR GLN GLN LEU ILE ARG ALA ALA GLU SEQRES 79 A 1285 ILE ARG ALA SER ALA ASN LEU ALA ALA THR LYS MET SER SEQRES 80 A 1285 GLU CYS VAL LEU GLY GLN SER LYS ARG VAL ASP PHE CYS SEQRES 81 A 1285 GLY LYS GLY TYR HIS LEU MET SER PHE PRO GLN SER ALA SEQRES 82 A 1285 PRO HIS GLY VAL VAL PHE LEU HIS VAL THR TYR VAL PRO SEQRES 83 A 1285 ALA GLN GLU LYS ASN PHE THR THR ALA PRO ALA ILE CYS SEQRES 84 A 1285 HIS ASP GLY LYS ALA HIS PHE PRO ARG GLU GLY VAL PHE SEQRES 85 A 1285 VAL SER ASN GLY THR HIS TRP PHE VAL THR GLN ARG ASN SEQRES 86 A 1285 PHE TYR GLU PRO GLN ILE ILE THR THR ASP ASN THR PHE SEQRES 87 A 1285 VAL SER GLY ASN CYS ASP VAL VAL ILE GLY ILE VAL ASN SEQRES 88 A 1285 ASN THR VAL TYR ASP PRO LEU GLN PRO GLU LEU ASP SER SEQRES 89 A 1285 PHE LYS GLU GLU LEU ASP LYS TYR PHE LYS ASN HIS THR SEQRES 90 A 1285 SER PRO ASP VAL ASP LEU GLY ASP ILE SER GLY ILE ASN SEQRES 91 A 1285 ALA SER VAL VAL ASN ILE GLN LYS GLU ILE ASP ARG LEU SEQRES 92 A 1285 ASN GLU VAL ALA LYS ASN LEU ASN GLU SER LEU ILE ASP SEQRES 93 A 1285 LEU GLN GLU LEU GLY LYS TYR GLU GLN GLY SER GLY TYR SEQRES 94 A 1285 ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA TYR VAL ARG SEQRES 95 A 1285 LYS ASP GLY GLU TRP VAL LEU LEU SER THR PHE LEU GLY SEQRES 96 A 1285 ARG SER LEU GLU VAL LEU PHE GLN GLY PRO GLY HIS HIS SEQRES 97 A 1285 HIS HIS HIS HIS HIS HIS SER ALA TRP SER HIS PRO GLN SEQRES 98 A 1285 PHE GLU LYS GLY GLY GLY SER GLY GLY GLY GLY SER GLY SEQRES 99 A 1285 GLY SER ALA TRP SER HIS PRO GLN PHE GLU LYS SEQRES 1 B 1285 MET PHE VAL PHE LEU VAL LEU LEU PRO LEU VAL SER SER SEQRES 2 B 1285 GLN CYS VAL ASN LEU ILE THR ARG THR GLN SER TYR THR SEQRES 3 B 1285 ASN SER PHE THR ARG GLY VAL TYR TYR PRO ASP LYS VAL SEQRES 4 B 1285 PHE ARG SER SER VAL LEU HIS SER THR GLN ASP LEU PHE SEQRES 5 B 1285 LEU PRO PHE PHE SER ASN VAL THR TRP PHE HIS ALA ILE SEQRES 6 B 1285 HIS VAL SER GLY THR ASN GLY THR LYS ARG PHE ASP ASN SEQRES 7 B 1285 PRO VAL LEU PRO PHE ASN ASP GLY VAL TYR PHE ALA SER SEQRES 8 B 1285 THR GLU LYS SER ASN ILE ILE ARG GLY TRP ILE PHE GLY SEQRES 9 B 1285 THR THR LEU ASP SER LYS THR GLN SER LEU LEU ILE VAL SEQRES 10 B 1285 ASN ASN ALA THR ASN VAL VAL ILE LYS VAL CYS GLU PHE SEQRES 11 B 1285 GLN PHE CYS ASN ASP PRO PHE LEU ASP VAL TYR TYR HIS SEQRES 12 B 1285 LYS ASN ASN LYS SER TRP MET GLU SER GLU PHE ARG VAL SEQRES 13 B 1285 TYR SER SER ALA ASN ASN CYS THR PHE GLU TYR VAL SER SEQRES 14 B 1285 GLN PRO PHE LEU MET ASP LEU GLU GLY LYS GLN GLY ASN SEQRES 15 B 1285 PHE LYS ASN LEU ARG GLU PHE VAL PHE LYS ASN ILE ASP SEQRES 16 B 1285 GLY TYR PHE LYS ILE TYR SER LYS HIS THR PRO ILE ASN SEQRES 17 B 1285 LEU GLY ARG ASP LEU PRO GLN GLY PHE SER ALA LEU GLU SEQRES 18 B 1285 PRO LEU VAL ASP LEU PRO ILE GLY ILE ASN ILE THR ARG SEQRES 19 B 1285 PHE GLN THR LEU LEU ALA LEU HIS ARG SER TYR LEU THR SEQRES 20 B 1285 PRO GLY ASP SER SER SER GLY TRP THR ALA GLY ALA ALA SEQRES 21 B 1285 ALA TYR TYR VAL GLY TYR LEU GLN PRO ARG THR PHE LEU SEQRES 22 B 1285 LEU LYS TYR ASN GLU ASN GLY THR ILE THR ASP ALA VAL SEQRES 23 B 1285 ASP CYS ALA LEU ASP PRO LEU SER GLU THR LYS CYS THR SEQRES 24 B 1285 LEU LYS SER PHE THR VAL GLU LYS GLY ILE TYR GLN THR SEQRES 25 B 1285 SER ASN PHE ARG VAL GLN PRO THR GLU SER ILE VAL ARG SEQRES 26 B 1285 PHE PRO ASN ILE THR ASN LEU CYS PRO PHE ASP GLU VAL SEQRES 27 B 1285 PHE ASN ALA THR ARG PHE ALA SER VAL TYR ALA TRP ASN SEQRES 28 B 1285 ARG LYS ARG ILE SER ASN CYS VAL ALA ASP TYR SER VAL SEQRES 29 B 1285 LEU TYR ASN PHE ALA PRO PHE PHE ALA PHE LYS CYS TYR SEQRES 30 B 1285 GLY VAL SER PRO THR LYS LEU ASN ASP LEU CYS PHE THR SEQRES 31 B 1285 ASN VAL TYR ALA ASP SER PHE VAL ILE ARG GLY ASN GLU SEQRES 32 B 1285 VAL SER GLN ILE ALA PRO GLY GLN THR GLY ASN ILE ALA SEQRES 33 B 1285 ASP TYR ASN TYR LYS LEU PRO ASP ASP PHE THR GLY CYS SEQRES 34 B 1285 VAL ILE ALA TRP ASN SER ASN LYS LEU ASP SER LYS VAL SEQRES 35 B 1285 GLY GLY ASN TYR ASN TYR LEU TYR ARG LEU PHE ARG LYS SEQRES 36 B 1285 SER ASN LEU LYS PRO PHE GLU ARG ASP ILE SER THR GLU SEQRES 37 B 1285 ILE TYR GLN ALA GLY ASN LYS PRO CYS ASN GLY VAL ALA SEQRES 38 B 1285 GLY PHE ASN CYS TYR PHE PRO LEU ARG SER TYR GLY PHE SEQRES 39 B 1285 ARG PRO THR TYR GLY VAL GLY HIS GLN PRO TYR ARG VAL SEQRES 40 B 1285 VAL VAL LEU SER PHE GLU LEU LEU HIS ALA PRO ALA THR SEQRES 41 B 1285 VAL CYS GLY PRO LYS LYS SER THR ASN LEU VAL LYS ASN SEQRES 42 B 1285 LYS CYS VAL ASN PHE ASN PHE ASN GLY LEU THR GLY THR SEQRES 43 B 1285 GLY VAL LEU THR GLU SER ASN LYS LYS PHE LEU PRO PHE SEQRES 44 B 1285 GLN GLN PHE GLY ARG ASP ILE ALA ASP THR THR ASP ALA SEQRES 45 B 1285 VAL ARG ASP PRO GLN THR LEU GLU ILE LEU ASP ILE THR SEQRES 46 B 1285 PRO CYS SER PHE GLY GLY VAL SER VAL ILE THR PRO GLY SEQRES 47 B 1285 THR ASN THR SER ASN GLN VAL ALA VAL LEU TYR GLN GLY SEQRES 48 B 1285 VAL ASN CYS THR GLU VAL PRO VAL ALA ILE HIS ALA ASP SEQRES 49 B 1285 GLN LEU THR PRO THR TRP ARG VAL TYR SER THR GLY SER SEQRES 50 B 1285 ASN VAL PHE GLN THR ARG ALA GLY CYS LEU ILE GLY ALA SEQRES 51 B 1285 GLU TYR VAL ASN ASN SER TYR GLU CYS ASP ILE PRO ILE SEQRES 52 B 1285 GLY ALA GLY ILE CYS ALA SER TYR GLN THR GLN THR LYS SEQRES 53 B 1285 SER HIS GLY SER ALA SER SER VAL ALA SER GLN SER ILE SEQRES 54 B 1285 ILE ALA TYR THR MET SER LEU GLY ALA GLU ASN SER VAL SEQRES 55 B 1285 ALA TYR SER ASN ASN SER ILE ALA ILE PRO THR ASN PHE SEQRES 56 B 1285 THR ILE SER VAL THR THR GLU ILE LEU PRO VAL SER MET SEQRES 57 B 1285 THR LYS THR SER VAL ASP CYS THR MET TYR ILE CYS GLY SEQRES 58 B 1285 ASP SER THR GLU CYS SER ASN LEU LEU LEU GLN TYR GLY SEQRES 59 B 1285 SER PHE CYS THR GLN LEU LYS ARG ALA LEU THR GLY ILE SEQRES 60 B 1285 ALA VAL GLU GLN ASP LYS ASN THR GLN GLU VAL PHE ALA SEQRES 61 B 1285 GLN VAL LYS GLN ILE TYR LYS THR PRO PRO ILE LYS TYR SEQRES 62 B 1285 PHE GLY GLY PHE ASN PHE SER GLN ILE LEU PRO ASP PRO SEQRES 63 B 1285 SER LYS PRO SER LYS ARG SER PHE ILE GLU ASP LEU LEU SEQRES 64 B 1285 PHE ASN LYS VAL THR LEU ALA ASP ALA GLY PHE ILE LYS SEQRES 65 B 1285 GLN TYR GLY ASP CYS LEU GLY ASP ILE ALA ALA ARG ASP SEQRES 66 B 1285 LEU ILE CYS ALA GLN LYS PHE ASN GLY LEU THR VAL LEU SEQRES 67 B 1285 PRO PRO LEU LEU THR ASP GLU MET ILE ALA GLN TYR THR SEQRES 68 B 1285 SER ALA LEU LEU ALA GLY THR ILE THR SER GLY TRP THR SEQRES 69 B 1285 PHE GLY ALA GLY ALA ALA LEU GLN ILE PRO PHE ALA MET SEQRES 70 B 1285 GLN MET ALA TYR ARG PHE ASN GLY ILE GLY VAL THR GLN SEQRES 71 B 1285 ASN VAL LEU TYR GLU ASN GLN LYS LEU ILE ALA ASN GLN SEQRES 72 B 1285 PHE ASN SER ALA ILE GLY LYS ILE GLN ASP SER LEU SER SEQRES 73 B 1285 SER THR ALA SER ALA LEU GLY LYS LEU GLN ASP VAL VAL SEQRES 74 B 1285 ASN HIS ASN ALA GLN ALA LEU ASN THR LEU VAL LYS GLN SEQRES 75 B 1285 LEU SER SER LYS PHE GLY ALA ILE SER SER VAL LEU ASN SEQRES 76 B 1285 ASP ILE LEU SER ARG LEU ASP LYS VAL GLU ALA GLU VAL SEQRES 77 B 1285 GLN ILE ASP ARG LEU ILE THR GLY ARG LEU GLN SER LEU SEQRES 78 B 1285 GLN THR TYR VAL THR GLN GLN LEU ILE ARG ALA ALA GLU SEQRES 79 B 1285 ILE ARG ALA SER ALA ASN LEU ALA ALA THR LYS MET SER SEQRES 80 B 1285 GLU CYS VAL LEU GLY GLN SER LYS ARG VAL ASP PHE CYS SEQRES 81 B 1285 GLY LYS GLY TYR HIS LEU MET SER PHE PRO GLN SER ALA SEQRES 82 B 1285 PRO HIS GLY VAL VAL PHE LEU HIS VAL THR TYR VAL PRO SEQRES 83 B 1285 ALA GLN GLU LYS ASN PHE THR THR ALA PRO ALA ILE CYS SEQRES 84 B 1285 HIS ASP GLY LYS ALA HIS PHE PRO ARG GLU GLY VAL PHE SEQRES 85 B 1285 VAL SER ASN GLY THR HIS TRP PHE VAL THR GLN ARG ASN SEQRES 86 B 1285 PHE TYR GLU PRO GLN ILE ILE THR THR ASP ASN THR PHE SEQRES 87 B 1285 VAL SER GLY ASN CYS ASP VAL VAL ILE GLY ILE VAL ASN SEQRES 88 B 1285 ASN THR VAL TYR ASP PRO LEU GLN PRO GLU LEU ASP SER SEQRES 89 B 1285 PHE LYS GLU GLU LEU ASP LYS TYR PHE LYS ASN HIS THR SEQRES 90 B 1285 SER PRO ASP VAL ASP LEU GLY ASP ILE SER GLY ILE ASN SEQRES 91 B 1285 ALA SER VAL VAL ASN ILE GLN LYS GLU ILE ASP ARG LEU SEQRES 92 B 1285 ASN GLU VAL ALA LYS ASN LEU ASN GLU SER LEU ILE ASP SEQRES 93 B 1285 LEU GLN GLU LEU GLY LYS TYR GLU GLN GLY SER GLY TYR SEQRES 94 B 1285 ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA TYR VAL ARG SEQRES 95 B 1285 LYS ASP GLY GLU TRP VAL LEU LEU SER THR PHE LEU GLY SEQRES 96 B 1285 ARG SER LEU GLU VAL LEU PHE GLN GLY PRO GLY HIS HIS SEQRES 97 B 1285 HIS HIS HIS HIS HIS HIS SER ALA TRP SER HIS PRO GLN SEQRES 98 B 1285 PHE GLU LYS GLY GLY GLY SER GLY GLY GLY GLY SER GLY SEQRES 99 B 1285 GLY SER ALA TRP SER HIS PRO GLN PHE GLU LYS SEQRES 1 C 1285 MET PHE VAL PHE LEU VAL LEU LEU PRO LEU VAL SER SER SEQRES 2 C 1285 GLN CYS VAL ASN LEU ILE THR ARG THR GLN SER TYR THR SEQRES 3 C 1285 ASN SER PHE THR ARG GLY VAL TYR TYR PRO ASP LYS VAL SEQRES 4 C 1285 PHE ARG SER SER VAL LEU HIS SER THR GLN ASP LEU PHE SEQRES 5 C 1285 LEU PRO PHE PHE SER ASN VAL THR TRP PHE HIS ALA ILE SEQRES 6 C 1285 HIS VAL SER GLY THR ASN GLY THR LYS ARG PHE ASP ASN SEQRES 7 C 1285 PRO VAL LEU PRO PHE ASN ASP GLY VAL TYR PHE ALA SER SEQRES 8 C 1285 THR GLU LYS SER ASN ILE ILE ARG GLY TRP ILE PHE GLY SEQRES 9 C 1285 THR THR LEU ASP SER LYS THR GLN SER LEU LEU ILE VAL SEQRES 10 C 1285 ASN ASN ALA THR ASN VAL VAL ILE LYS VAL CYS GLU PHE SEQRES 11 C 1285 GLN PHE CYS ASN ASP PRO PHE LEU ASP VAL TYR TYR HIS SEQRES 12 C 1285 LYS ASN ASN LYS SER TRP MET GLU SER GLU PHE ARG VAL SEQRES 13 C 1285 TYR SER SER ALA ASN ASN CYS THR PHE GLU TYR VAL SER SEQRES 14 C 1285 GLN PRO PHE LEU MET ASP LEU GLU GLY LYS GLN GLY ASN SEQRES 15 C 1285 PHE LYS ASN LEU ARG GLU PHE VAL PHE LYS ASN ILE ASP SEQRES 16 C 1285 GLY TYR PHE LYS ILE TYR SER LYS HIS THR PRO ILE ASN SEQRES 17 C 1285 LEU GLY ARG ASP LEU PRO GLN GLY PHE SER ALA LEU GLU SEQRES 18 C 1285 PRO LEU VAL ASP LEU PRO ILE GLY ILE ASN ILE THR ARG SEQRES 19 C 1285 PHE GLN THR LEU LEU ALA LEU HIS ARG SER TYR LEU THR SEQRES 20 C 1285 PRO GLY ASP SER SER SER GLY TRP THR ALA GLY ALA ALA SEQRES 21 C 1285 ALA TYR TYR VAL GLY TYR LEU GLN PRO ARG THR PHE LEU SEQRES 22 C 1285 LEU LYS TYR ASN GLU ASN GLY THR ILE THR ASP ALA VAL SEQRES 23 C 1285 ASP CYS ALA LEU ASP PRO LEU SER GLU THR LYS CYS THR SEQRES 24 C 1285 LEU LYS SER PHE THR VAL GLU LYS GLY ILE TYR GLN THR SEQRES 25 C 1285 SER ASN PHE ARG VAL GLN PRO THR GLU SER ILE VAL ARG SEQRES 26 C 1285 PHE PRO ASN ILE THR ASN LEU CYS PRO PHE ASP GLU VAL SEQRES 27 C 1285 PHE ASN ALA THR ARG PHE ALA SER VAL TYR ALA TRP ASN SEQRES 28 C 1285 ARG LYS ARG ILE SER ASN CYS VAL ALA ASP TYR SER VAL SEQRES 29 C 1285 LEU TYR ASN PHE ALA PRO PHE PHE ALA PHE LYS CYS TYR SEQRES 30 C 1285 GLY VAL SER PRO THR LYS LEU ASN ASP LEU CYS PHE THR SEQRES 31 C 1285 ASN VAL TYR ALA ASP SER PHE VAL ILE ARG GLY ASN GLU SEQRES 32 C 1285 VAL SER GLN ILE ALA PRO GLY GLN THR GLY ASN ILE ALA SEQRES 33 C 1285 ASP TYR ASN TYR LYS LEU PRO ASP ASP PHE THR GLY CYS SEQRES 34 C 1285 VAL ILE ALA TRP ASN SER ASN LYS LEU ASP SER LYS VAL SEQRES 35 C 1285 GLY GLY ASN TYR ASN TYR LEU TYR ARG LEU PHE ARG LYS SEQRES 36 C 1285 SER ASN LEU LYS PRO PHE GLU ARG ASP ILE SER THR GLU SEQRES 37 C 1285 ILE TYR GLN ALA GLY ASN LYS PRO CYS ASN GLY VAL ALA SEQRES 38 C 1285 GLY PHE ASN CYS TYR PHE PRO LEU ARG SER TYR GLY PHE SEQRES 39 C 1285 ARG PRO THR TYR GLY VAL GLY HIS GLN PRO TYR ARG VAL SEQRES 40 C 1285 VAL VAL LEU SER PHE GLU LEU LEU HIS ALA PRO ALA THR SEQRES 41 C 1285 VAL CYS GLY PRO LYS LYS SER THR ASN LEU VAL LYS ASN SEQRES 42 C 1285 LYS CYS VAL ASN PHE ASN PHE ASN GLY LEU THR GLY THR SEQRES 43 C 1285 GLY VAL LEU THR GLU SER ASN LYS LYS PHE LEU PRO PHE SEQRES 44 C 1285 GLN GLN PHE GLY ARG ASP ILE ALA ASP THR THR ASP ALA SEQRES 45 C 1285 VAL ARG ASP PRO GLN THR LEU GLU ILE LEU ASP ILE THR SEQRES 46 C 1285 PRO CYS SER PHE GLY GLY VAL SER VAL ILE THR PRO GLY SEQRES 47 C 1285 THR ASN THR SER ASN GLN VAL ALA VAL LEU TYR GLN GLY SEQRES 48 C 1285 VAL ASN CYS THR GLU VAL PRO VAL ALA ILE HIS ALA ASP SEQRES 49 C 1285 GLN LEU THR PRO THR TRP ARG VAL TYR SER THR GLY SER SEQRES 50 C 1285 ASN VAL PHE GLN THR ARG ALA GLY CYS LEU ILE GLY ALA SEQRES 51 C 1285 GLU TYR VAL ASN ASN SER TYR GLU CYS ASP ILE PRO ILE SEQRES 52 C 1285 GLY ALA GLY ILE CYS ALA SER TYR GLN THR GLN THR LYS SEQRES 53 C 1285 SER HIS GLY SER ALA SER SER VAL ALA SER GLN SER ILE SEQRES 54 C 1285 ILE ALA TYR THR MET SER LEU GLY ALA GLU ASN SER VAL SEQRES 55 C 1285 ALA TYR SER ASN ASN SER ILE ALA ILE PRO THR ASN PHE SEQRES 56 C 1285 THR ILE SER VAL THR THR GLU ILE LEU PRO VAL SER MET SEQRES 57 C 1285 THR LYS THR SER VAL ASP CYS THR MET TYR ILE CYS GLY SEQRES 58 C 1285 ASP SER THR GLU CYS SER ASN LEU LEU LEU GLN TYR GLY SEQRES 59 C 1285 SER PHE CYS THR GLN LEU LYS ARG ALA LEU THR GLY ILE SEQRES 60 C 1285 ALA VAL GLU GLN ASP LYS ASN THR GLN GLU VAL PHE ALA SEQRES 61 C 1285 GLN VAL LYS GLN ILE TYR LYS THR PRO PRO ILE LYS TYR SEQRES 62 C 1285 PHE GLY GLY PHE ASN PHE SER GLN ILE LEU PRO ASP PRO SEQRES 63 C 1285 SER LYS PRO SER LYS ARG SER PHE ILE GLU ASP LEU LEU SEQRES 64 C 1285 PHE ASN LYS VAL THR LEU ALA ASP ALA GLY PHE ILE LYS SEQRES 65 C 1285 GLN TYR GLY ASP CYS LEU GLY ASP ILE ALA ALA ARG ASP SEQRES 66 C 1285 LEU ILE CYS ALA GLN LYS PHE ASN GLY LEU THR VAL LEU SEQRES 67 C 1285 PRO PRO LEU LEU THR ASP GLU MET ILE ALA GLN TYR THR SEQRES 68 C 1285 SER ALA LEU LEU ALA GLY THR ILE THR SER GLY TRP THR SEQRES 69 C 1285 PHE GLY ALA GLY ALA ALA LEU GLN ILE PRO PHE ALA MET SEQRES 70 C 1285 GLN MET ALA TYR ARG PHE ASN GLY ILE GLY VAL THR GLN SEQRES 71 C 1285 ASN VAL LEU TYR GLU ASN GLN LYS LEU ILE ALA ASN GLN SEQRES 72 C 1285 PHE ASN SER ALA ILE GLY LYS ILE GLN ASP SER LEU SER SEQRES 73 C 1285 SER THR ALA SER ALA LEU GLY LYS LEU GLN ASP VAL VAL SEQRES 74 C 1285 ASN HIS ASN ALA GLN ALA LEU ASN THR LEU VAL LYS GLN SEQRES 75 C 1285 LEU SER SER LYS PHE GLY ALA ILE SER SER VAL LEU ASN SEQRES 76 C 1285 ASP ILE LEU SER ARG LEU ASP LYS VAL GLU ALA GLU VAL SEQRES 77 C 1285 GLN ILE ASP ARG LEU ILE THR GLY ARG LEU GLN SER LEU SEQRES 78 C 1285 GLN THR TYR VAL THR GLN GLN LEU ILE ARG ALA ALA GLU SEQRES 79 C 1285 ILE ARG ALA SER ALA ASN LEU ALA ALA THR LYS MET SER SEQRES 80 C 1285 GLU CYS VAL LEU GLY GLN SER LYS ARG VAL ASP PHE CYS SEQRES 81 C 1285 GLY LYS GLY TYR HIS LEU MET SER PHE PRO GLN SER ALA SEQRES 82 C 1285 PRO HIS GLY VAL VAL PHE LEU HIS VAL THR TYR VAL PRO SEQRES 83 C 1285 ALA GLN GLU LYS ASN PHE THR THR ALA PRO ALA ILE CYS SEQRES 84 C 1285 HIS ASP GLY LYS ALA HIS PHE PRO ARG GLU GLY VAL PHE SEQRES 85 C 1285 VAL SER ASN GLY THR HIS TRP PHE VAL THR GLN ARG ASN SEQRES 86 C 1285 PHE TYR GLU PRO GLN ILE ILE THR THR ASP ASN THR PHE SEQRES 87 C 1285 VAL SER GLY ASN CYS ASP VAL VAL ILE GLY ILE VAL ASN SEQRES 88 C 1285 ASN THR VAL TYR ASP PRO LEU GLN PRO GLU LEU ASP SER SEQRES 89 C 1285 PHE LYS GLU GLU LEU ASP LYS TYR PHE LYS ASN HIS THR SEQRES 90 C 1285 SER PRO ASP VAL ASP LEU GLY ASP ILE SER GLY ILE ASN SEQRES 91 C 1285 ALA SER VAL VAL ASN ILE GLN LYS GLU ILE ASP ARG LEU SEQRES 92 C 1285 ASN GLU VAL ALA LYS ASN LEU ASN GLU SER LEU ILE ASP SEQRES 93 C 1285 LEU GLN GLU LEU GLY LYS TYR GLU GLN GLY SER GLY TYR SEQRES 94 C 1285 ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA TYR VAL ARG SEQRES 95 C 1285 LYS ASP GLY GLU TRP VAL LEU LEU SER THR PHE LEU GLY SEQRES 96 C 1285 ARG SER LEU GLU VAL LEU PHE GLN GLY PRO GLY HIS HIS SEQRES 97 C 1285 HIS HIS HIS HIS HIS HIS SER ALA TRP SER HIS PRO GLN SEQRES 98 C 1285 PHE GLU LYS GLY GLY GLY SER GLY GLY GLY GLY SER GLY SEQRES 99 C 1285 GLY SER ALA TRP SER HIS PRO GLN PHE GLU LYS HET NAG D 1 14 HET NAG D 2 14 HET NAG E 1 14 HET NAG E 2 14 HET NAG F 1 14 HET NAG F 2 14 HET NAG G 1 14 HET NAG G 2 14 HET NAG A1301 14 HET NAG A1302 14 HET NAG A1303 14 HET NAG A1304 14 HET NAG A1305 14 HET NAG A1306 14 HET NAG A1307 14 HET NAG A1308 14 HET NAG A1309 14 HET NAG A1310 14 HET NAG A1311 14 HET NAG A1312 14 HET NAG B1301 14 HET NAG B1302 14 HET NAG B1303 14 HET NAG B1304 14 HET NAG B1305 14 HET NAG B1306 14 HET NAG B1307 14 HET NAG B1308 14 HET NAG C1301 14 HET NAG C1302 14 HET NAG C1303 14 HET NAG C1304 14 HET NAG C1305 14 HET NAG C1306 14 HET NAG C1307 14 HET NAG C1308 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE FORMUL 4 NAG 36(C8 H15 N O6) HELIX 1 AA1 ASP A 294 LYS A 304 1 11 HELIX 2 AA2 PRO A 337 ASN A 343 1 7 HELIX 3 AA3 SER A 349 TRP A 353 5 5 HELIX 4 AA4 ASP A 364 SER A 366 5 3 HELIX 5 AA5 VAL A 367 ALA A 372 1 6 HELIX 6 AA6 THR A 385 ASP A 389 5 5 HELIX 7 AA7 ASN A 405 ILE A 410 5 6 HELIX 8 AA8 GLY A 416 ASN A 422 1 7 HELIX 9 AA9 ASN A 616 VAL A 620 5 5 HELIX 10 AB1 ASP A 737 CYS A 743 1 7 HELIX 11 AB2 SER A 746 GLY A 757 1 12 HELIX 12 AB3 PHE A 759 ALA A 783 1 25 HELIX 13 AB4 SER A 816 LYS A 825 1 10 HELIX 14 AB5 GLN A 836 GLY A 842 1 7 HELIX 15 AB6 ASP A 848 PHE A 855 1 8 HELIX 16 AB7 THR A 866 SER A 884 1 19 HELIX 17 AB8 PRO A 897 GLY A 908 1 12 HELIX 18 AB9 GLN A 913 SER A 939 1 27 HELIX 19 AC1 LEU A 945 GLN A 965 1 21 HELIX 20 AC2 LEU A 966 SER A 968 5 3 HELIX 21 AC3 VAL A 976 LEU A 984 1 9 HELIX 22 AC4 ASP A 985 CYS A 1032 1 48 HELIX 23 AC5 PRO A 1140 SER A 1147 1 8 HELIX 24 AC6 ASP B 294 LYS B 304 1 11 HELIX 25 AC7 PRO B 337 ASN B 343 1 7 HELIX 26 AC8 SER B 349 TRP B 353 5 5 HELIX 27 AC9 ASP B 364 ASN B 370 5 7 HELIX 28 AD1 ARG B 403 ILE B 410 5 8 HELIX 29 AD2 GLY B 416 ASN B 422 1 7 HELIX 30 AD3 ASN B 616 VAL B 620 5 5 HELIX 31 AD4 ASP B 737 GLY B 744 1 8 HELIX 32 AD5 SER B 746 LEU B 754 1 9 HELIX 33 AD6 GLN B 755 GLY B 757 5 3 HELIX 34 AD7 SER B 758 ALA B 783 1 26 HELIX 35 AD8 SER B 816 LYS B 825 1 10 HELIX 36 AD9 LYS B 835 GLY B 842 1 8 HELIX 37 AE1 LEU B 849 GLY B 857 1 9 HELIX 38 AE2 THR B 866 GLY B 885 1 20 HELIX 39 AE3 PRO B 897 GLY B 908 1 12 HELIX 40 AE4 THR B 912 ASN B 919 1 8 HELIX 41 AE5 ASN B 919 THR B 941 1 23 HELIX 42 AE6 GLY B 946 GLN B 965 1 20 HELIX 43 AE7 LEU B 966 SER B 968 5 3 HELIX 44 AE8 VAL B 976 LEU B 984 1 9 HELIX 45 AE9 ASP B 985 CYS B 1032 1 48 HELIX 46 AF1 LEU B 1141 LEU B 1145 5 5 HELIX 47 AF2 ASP C 294 LYS C 304 1 11 HELIX 48 AF3 PHE C 338 ASN C 343 1 6 HELIX 49 AF4 VAL C 367 ALA C 372 1 6 HELIX 50 AF5 THR C 385 ASP C 389 5 5 HELIX 51 AF6 GLY C 416 ASN C 422 1 7 HELIX 52 AF7 ASP C 737 CYS C 743 1 7 HELIX 53 AF8 THR C 747 TYR C 756 1 10 HELIX 54 AF9 SER C 758 ALA C 783 1 26 HELIX 55 AG1 SER C 816 VAL C 826 1 11 HELIX 56 AG2 TYR C 837 GLY C 842 1 6 HELIX 57 AG3 ASP C 848 ASN C 856 1 9 HELIX 58 AG4 THR C 866 GLY C 885 1 20 HELIX 59 AG5 TRP C 886 GLY C 891 1 6 HELIX 60 AG6 PRO C 897 GLY C 910 1 14 HELIX 61 AG7 THR C 912 ASN C 919 1 8 HELIX 62 AG8 ASN C 919 THR C 941 1 23 HELIX 63 AG9 LEU C 945 GLN C 965 1 21 HELIX 64 AH1 LEU C 966 SER C 968 5 3 HELIX 65 AH2 VAL C 976 LEU C 984 1 9 HELIX 66 AH3 ASP C 985 VAL C 1033 1 49 HELIX 67 AH4 PRO C 1140 SER C 1147 1 8 SHEET 1 AA1 7 THR A 25 ASN A 30 0 SHEET 2 AA1 7 ASN A 61 ALA A 67 -1 O VAL A 62 N THR A 29 SHEET 3 AA1 7 ALA A 263 TYR A 269 -1 O TYR A 265 N PHE A 65 SHEET 4 AA1 7 GLY A 89 SER A 94 -1 N TYR A 91 O GLY A 268 SHEET 5 AA1 7 ASN A 188 ASN A 196 -1 O PHE A 192 N PHE A 92 SHEET 6 AA1 7 PHE A 201 PRO A 209 -1 O LYS A 202 N LYS A 195 SHEET 7 AA1 7 GLU A 224 LEU A 229 -1 O GLU A 224 N SER A 205 SHEET 1 AA2 7 VAL A 42 PHE A 43 0 SHEET 2 AA2 7 PHE C 565 ARG C 567 1 O PHE C 565 N PHE A 43 SHEET 3 AA2 7 THR C 573 ARG C 577 -1 O ALA C 575 N GLY C 566 SHEET 4 AA2 7 ILE C 584 THR C 588 -1 O ILE C 587 N ASP C 574 SHEET 5 AA2 7 LEU C 546 GLU C 554 -1 N VAL C 551 O THR C 588 SHEET 6 AA2 7 CYS C 538 PHE C 543 -1 N VAL C 539 O GLY C 550 SHEET 7 AA2 7 SER C 325 ARG C 328 1 N ARG C 328 O ASN C 542 SHEET 1 AA3 3 VAL A 47 PHE A 55 0 SHEET 2 AA3 3 GLN A 271 TYR A 279 -1 O ARG A 273 N ASP A 53 SHEET 3 AA3 3 ILE A 285 ASP A 290 -1 O ASP A 287 N LYS A 278 SHEET 1 AA4 6 LEU A 84 PRO A 85 0 SHEET 2 AA4 6 ARG A 237 THR A 240 -1 O PHE A 238 N LEU A 84 SHEET 3 AA4 6 TRP A 104 GLY A 107 -1 N ILE A 105 O GLN A 239 SHEET 4 AA4 6 SER A 116 ASN A 121 -1 O ILE A 119 N TRP A 104 SHEET 5 AA4 6 VAL A 126 CYS A 131 -1 O VAL A 127 N VAL A 120 SHEET 6 AA4 6 PHE A 168 SER A 172 -1 O PHE A 168 N VAL A 130 SHEET 1 AA5 5 GLY A 311 ARG A 319 0 SHEET 2 AA5 5 PHE A 592 THR A 599 -1 O VAL A 597 N TYR A 313 SHEET 3 AA5 5 ALA A 609 GLN A 613 -1 O LEU A 611 N SER A 596 SHEET 4 AA5 5 GLY A 648 ILE A 651 -1 O CYS A 649 N TYR A 612 SHEET 5 AA5 5 VAL A 642 GLN A 644 -1 N PHE A 643 O LEU A 650 SHEET 1 AA6 7 GLU A 324 ARG A 328 0 SHEET 2 AA6 7 CYS A 538 PHE A 543 1 O ASN A 542 N ARG A 328 SHEET 3 AA6 7 LEU A 546 GLU A 554 -1 O GLY A 550 N VAL A 539 SHEET 4 AA6 7 ILE A 584 THR A 588 -1 O THR A 588 N VAL A 551 SHEET 5 AA6 7 THR A 573 ARG A 577 -1 N ASP A 574 O ILE A 587 SHEET 6 AA6 7 PHE A 565 ARG A 567 -1 N GLY A 566 O ALA A 575 SHEET 7 AA6 7 VAL B 42 PHE B 43 1 O PHE B 43 N PHE A 565 SHEET 1 AA7 5 ASN A 354 ILE A 358 0 SHEET 2 AA7 5 VAL A 395 ARG A 403 -1 O ALA A 397 N LYS A 356 SHEET 3 AA7 5 PRO A 507 SER A 514 -1 O TYR A 508 N ILE A 402 SHEET 4 AA7 5 GLY A 431 ASN A 437 -1 N TRP A 436 O ARG A 509 SHEET 5 AA7 5 LYS A 378 CYS A 379 -1 N LYS A 378 O VAL A 433 SHEET 1 AA8 2 CYS A 361 VAL A 362 0 SHEET 2 AA8 2 VAL A 524 CYS A 525 1 O CYS A 525 N CYS A 361 SHEET 1 AA9 2 LEU A 452 ARG A 454 0 SHEET 2 AA9 2 LEU A 492 SER A 494 -1 O ARG A 493 N TYR A 453 SHEET 1 AB1 2 TYR A 473 GLN A 474 0 SHEET 2 AB1 2 CYS A 488 TYR A 489 -1 O TYR A 489 N TYR A 473 SHEET 1 AB2 4 GLU A 654 TYR A 660 0 SHEET 2 AB2 4 SER A 691 MET A 697 1 O ALA A 694 N GLU A 654 SHEET 3 AB2 4 ILE A 670 GLN A 675 -1 N GLN A 675 O SER A 691 SHEET 4 AB2 4 ILE A 664 GLY A 667 -1 N ILE A 664 O ALA A 672 SHEET 1 AB3 2 ALA A 701 SER A 704 0 SHEET 2 AB3 2 GLN B 787 LYS B 790 1 O ILE B 788 N ASN A 703 SHEET 1 AB4 4 SER A 711 ALA A 713 0 SHEET 2 AB4 4 ASN A1074 ALA A1078 -1 O PHE A1075 N ILE A 712 SHEET 3 AB4 4 VAL A1094 SER A1097 -1 O SER A1097 N THR A1076 SHEET 4 AB4 4 TRP A1102 THR A1105 -1 O PHE A1103 N VAL A1096 SHEET 1 AB5 3 PHE A 718 PRO A 728 0 SHEET 2 AB5 3 GLY A1059 PRO A1069 -1 O PHE A1062 N GLU A 725 SHEET 3 AB5 3 TYR A1047 ALA A1056 -1 N TYR A1047 O TYR A1067 SHEET 1 AB6 2 THR A 734 VAL A 736 0 SHEET 2 AB6 2 LEU A 858 VAL A 860 -1 O THR A 859 N SER A 735 SHEET 1 AB7 2 ILE A 788 LYS A 790 0 SHEET 2 AB7 2 GLU C 702 SER C 704 1 O ASN C 703 N ILE A 788 SHEET 1 AB8 4 THR A1120 ASN A1125 0 SHEET 2 AB8 4 LYS A1086 PRO A1090 -1 N PHE A1089 O PHE A1121 SHEET 3 AB8 4 ILE A1081 HIS A1083 -1 N ILE A1081 O HIS A1088 SHEET 4 AB8 4 VAL A1133 ASN A1134 1 O VAL A1133 N CYS A1082 SHEET 1 AB9 8 THR B 23 ASN B 30 0 SHEET 2 AB9 8 ASN B 61 ILE B 68 -1 O ILE B 68 N THR B 23 SHEET 3 AB9 8 ALA B 264 TYR B 269 -1 O TYR B 265 N PHE B 65 SHEET 4 AB9 8 VAL B 90 SER B 94 -1 N TYR B 91 O GLY B 268 SHEET 5 AB9 8 ASN B 188 ILE B 197 -1 O PHE B 192 N PHE B 92 SHEET 6 AB9 8 TYR B 200 PRO B 209 -1 O THR B 208 N LEU B 189 SHEET 7 AB9 8 ALA B 222 LEU B 229 -1 O LEU B 229 N PHE B 201 SHEET 8 AB9 8 VAL B 36 TYR B 37 1 N VAL B 36 O LEU B 223 SHEET 1 AC1 3 LEU B 48 PHE B 55 0 SHEET 2 AC1 3 GLN B 271 TYR B 279 -1 O LEU B 277 N HIS B 49 SHEET 3 AC1 3 ILE B 285 ASP B 290 -1 O ASP B 287 N LYS B 278 SHEET 1 AC2 6 LEU B 84 PRO B 85 0 SHEET 2 AC2 6 ARG B 237 LEU B 241 -1 O PHE B 238 N LEU B 84 SHEET 3 AC2 6 GLY B 103 GLY B 107 -1 N GLY B 107 O ARG B 237 SHEET 4 AC2 6 LEU B 117 ASN B 122 -1 O ILE B 119 N TRP B 104 SHEET 5 AC2 6 ASN B 125 LYS B 129 -1 O VAL B 127 N VAL B 120 SHEET 6 AC2 6 TYR B 170 SER B 172 -1 O TYR B 170 N ILE B 128 SHEET 1 AC3 5 LYS B 310 ARG B 319 0 SHEET 2 AC3 5 PHE B 592 PRO B 600 -1 O THR B 599 N GLY B 311 SHEET 3 AC3 5 ALA B 609 GLN B 613 -1 O ALA B 609 N ILE B 598 SHEET 4 AC3 5 GLY B 648 ILE B 651 -1 O ILE B 651 N VAL B 610 SHEET 5 AC3 5 VAL B 642 GLN B 644 -1 N PHE B 643 O LEU B 650 SHEET 1 AC4 7 SER B 325 ARG B 328 0 SHEET 2 AC4 7 CYS B 538 PHE B 543 1 O ASN B 542 N ARG B 328 SHEET 3 AC4 7 LEU B 546 GLU B 554 -1 O GLY B 548 N PHE B 541 SHEET 4 AC4 7 ILE B 584 THR B 588 -1 O THR B 588 N VAL B 551 SHEET 5 AC4 7 THR B 573 ARG B 577 -1 N VAL B 576 O LEU B 585 SHEET 6 AC4 7 PHE B 565 ARG B 567 -1 N GLY B 566 O ASP B 574 SHEET 7 AC4 7 VAL C 42 PHE C 43 1 O PHE C 43 N PHE B 565 SHEET 1 AC5 5 ASN B 354 ILE B 358 0 SHEET 2 AC5 5 VAL B 395 ILE B 402 -1 O VAL B 395 N ILE B 358 SHEET 3 AC5 5 TYR B 508 PHE B 515 -1 O VAL B 510 N PHE B 400 SHEET 4 AC5 5 GLY B 431 ASN B 437 -1 N TRP B 436 O ARG B 509 SHEET 5 AC5 5 PHE B 377 TYR B 380 -1 N LYS B 378 O VAL B 433 SHEET 1 AC6 3 CYS B 361 VAL B 362 0 SHEET 2 AC6 3 VAL B 524 CYS B 525 1 O CYS B 525 N CYS B 361 SHEET 3 AC6 3 CYS B 391 PHE B 392 -1 N PHE B 392 O VAL B 524 SHEET 1 AC7 2 LEU B 452 ARG B 454 0 SHEET 2 AC7 2 LEU B 492 SER B 494 -1 O ARG B 493 N TYR B 453 SHEET 1 AC8 2 TYR B 473 GLN B 474 0 SHEET 2 AC8 2 CYS B 488 TYR B 489 -1 O TYR B 489 N TYR B 473 SHEET 1 AC9 4 GLU B 654 TYR B 655 0 SHEET 2 AC9 4 ILE B 693 THR B 696 1 O ALA B 694 N GLU B 654 SHEET 3 AC9 4 ILE B 670 SER B 673 -1 N CYS B 671 O TYR B 695 SHEET 4 AC9 4 ILE B 664 PRO B 665 -1 N ILE B 664 O ALA B 672 SHEET 1 AD1 2 ALA B 701 GLU B 702 0 SHEET 2 AD1 2 GLN C 787 ILE C 788 1 O ILE C 788 N ALA B 701 SHEET 1 AD2 2 SER B 711 PRO B 715 0 SHEET 2 AD2 2 GLU B1072 THR B1076 -1 O PHE B1075 N ILE B 712 SHEET 1 AD3 3 PHE B 718 PRO B 728 0 SHEET 2 AD3 3 GLY B1059 PRO B1069 -1 O PHE B1062 N GLU B 725 SHEET 3 AD3 3 TYR B1047 ALA B1056 -1 N GLN B1054 O VAL B1061 SHEET 1 AD4 2 THR B 734 VAL B 736 0 SHEET 2 AD4 2 LEU B 858 VAL B 860 -1 O THR B 859 N SER B 735 SHEET 1 AD5 4 THR B1120 VAL B1122 0 SHEET 2 AD5 4 LYS B1086 PRO B1090 -1 N PHE B1089 O PHE B1121 SHEET 3 AD5 4 ILE B1081 HIS B1083 -1 N ILE B1081 O HIS B1088 SHEET 4 AD5 4 VAL B1133 ASN B1134 1 O VAL B1133 N CYS B1082 SHEET 1 AD6 3 VAL B1094 SER B1097 0 SHEET 2 AD6 3 TRP B1102 THR B1105 -1 O PHE B1103 N VAL B1096 SHEET 3 AD6 3 GLN B1113 ILE B1114 -1 O GLN B1113 N VAL B1104 SHEET 1 AD7 7 SER C 27 ASN C 30 0 SHEET 2 AD7 7 ASN C 61 TRP C 64 -1 O VAL C 62 N THR C 29 SHEET 3 AD7 7 TYR C 266 TYR C 269 -1 O VAL C 267 N THR C 63 SHEET 4 AD7 7 VAL C 90 ALA C 93 -1 N TYR C 91 O GLY C 268 SHEET 5 AD7 7 ASN C 188 ASN C 196 -1 O PHE C 192 N PHE C 92 SHEET 6 AD7 7 PHE C 201 PRO C 209 -1 O LYS C 202 N LYS C 195 SHEET 7 AD7 7 GLU C 224 LEU C 229 -1 O LEU C 226 N ILE C 203 SHEET 1 AD8 3 LEU C 48 PHE C 55 0 SHEET 2 AD8 3 GLN C 271 TYR C 279 -1 O PHE C 275 N THR C 51 SHEET 3 AD8 3 ILE C 285 ASP C 290 -1 O ASP C 287 N LYS C 278 SHEET 1 AD9 6 LEU C 84 PRO C 85 0 SHEET 2 AD9 6 ARG C 237 THR C 240 -1 O PHE C 238 N LEU C 84 SHEET 3 AD9 6 TRP C 104 GLY C 107 -1 N ILE C 105 O GLN C 239 SHEET 4 AD9 6 LEU C 118 VAL C 120 -1 O ILE C 119 N TRP C 104 SHEET 5 AD9 6 VAL C 126 LYS C 129 -1 O VAL C 127 N VAL C 120 SHEET 6 AD9 6 GLU C 169 SER C 172 -1 O TYR C 170 N ILE C 128 SHEET 1 AE1 5 GLY C 311 ARG C 319 0 SHEET 2 AE1 5 PHE C 592 THR C 599 -1 O THR C 599 N GLY C 311 SHEET 3 AE1 5 ALA C 609 GLN C 613 -1 O LEU C 611 N SER C 596 SHEET 4 AE1 5 CYS C 649 ILE C 651 -1 O ILE C 651 N VAL C 610 SHEET 5 AE1 5 VAL C 642 GLN C 644 -1 N PHE C 643 O LEU C 650 SHEET 1 AE2 5 ASN C 354 ILE C 358 0 SHEET 2 AE2 5 VAL C 395 ARG C 403 -1 O VAL C 395 N ILE C 358 SHEET 3 AE2 5 PRO C 507 PHE C 515 -1 O VAL C 510 N PHE C 400 SHEET 4 AE2 5 GLY C 431 ASN C 437 -1 N ILE C 434 O VAL C 511 SHEET 5 AE2 5 LYS C 378 TYR C 380 -1 N TYR C 380 O GLY C 431 SHEET 1 AE3 2 LEU C 452 TYR C 453 0 SHEET 2 AE3 2 ARG C 493 SER C 494 -1 O ARG C 493 N TYR C 453 SHEET 1 AE4 2 TYR C 473 GLN C 474 0 SHEET 2 AE4 2 CYS C 488 TYR C 489 -1 O TYR C 489 N TYR C 473 SHEET 1 AE5 4 GLU C 654 TYR C 655 0 SHEET 2 AE5 4 GLN C 690 THR C 696 1 O ALA C 694 N GLU C 654 SHEET 3 AE5 4 ILE C 670 THR C 676 -1 N SER C 673 O ILE C 693 SHEET 4 AE5 4 ILE C 664 PRO C 665 -1 N ILE C 664 O ALA C 672 SHEET 1 AE6 5 SER C 711 PRO C 715 0 SHEET 2 AE6 5 GLU C1072 THR C1077 -1 O PHE C1075 N ILE C 712 SHEET 3 AE6 5 VAL C1094 SER C1097 -1 O SER C1097 N THR C1076 SHEET 4 AE6 5 TRP C1102 THR C1105 -1 O PHE C1103 N VAL C1096 SHEET 5 AE6 5 GLN C1113 ILE C1114 -1 O GLN C1113 N VAL C1104 SHEET 1 AE7 3 PHE C 718 PRO C 728 0 SHEET 2 AE7 3 GLY C1059 PRO C1069 -1 O PHE C1062 N GLU C 725 SHEET 3 AE7 3 TYR C1047 ALA C1056 -1 N MET C1050 O VAL C1065 SHEET 1 AE8 2 LYS C 733 VAL C 736 0 SHEET 2 AE8 2 LEU C 858 LEU C 861 -1 O LEU C 861 N LYS C 733 SHEET 1 AE9 4 THR C1120 VAL C1122 0 SHEET 2 AE9 4 LYS C1086 PRO C1090 -1 N PHE C1089 O PHE C1121 SHEET 3 AE9 4 ILE C1081 HIS C1083 -1 N ILE C1081 O HIS C1088 SHEET 4 AE9 4 VAL C1133 ASN C1134 1 O VAL C1133 N CYS C1082 SSBOND 1 CYS A 131 CYS A 166 1555 1555 2.04 SSBOND 2 CYS A 291 CYS A 301 1555 1555 2.03 SSBOND 3 CYS A 336 CYS A 361 1555 1555 2.03 SSBOND 4 CYS A 379 CYS A 432 1555 1555 2.03 SSBOND 5 CYS A 391 CYS A 525 1555 1555 2.03 SSBOND 6 CYS A 480 CYS A 488 1555 1555 2.03 SSBOND 7 CYS A 538 CYS A 590 1555 1555 2.03 SSBOND 8 CYS A 617 CYS A 649 1555 1555 2.03 SSBOND 9 CYS A 662 CYS A 671 1555 1555 2.03 SSBOND 10 CYS A 738 CYS A 760 1555 1555 2.03 SSBOND 11 CYS A 743 CYS A 749 1555 1555 2.03 SSBOND 12 CYS A 840 CYS A 851 1555 1555 2.03 SSBOND 13 CYS A 1032 CYS A 1043 1555 1555 2.02 SSBOND 14 CYS A 1082 CYS A 1126 1555 1555 2.03 SSBOND 15 CYS B 131 CYS B 166 1555 1555 2.04 SSBOND 16 CYS B 291 CYS B 301 1555 1555 2.03 SSBOND 17 CYS B 336 CYS B 361 1555 1555 2.03 SSBOND 18 CYS B 379 CYS B 432 1555 1555 2.03 SSBOND 19 CYS B 391 CYS B 525 1555 1555 2.03 SSBOND 20 CYS B 480 CYS B 488 1555 1555 2.03 SSBOND 21 CYS B 538 CYS B 590 1555 1555 2.03 SSBOND 22 CYS B 617 CYS B 649 1555 1555 2.03 SSBOND 23 CYS B 662 CYS B 671 1555 1555 2.03 SSBOND 24 CYS B 738 CYS B 760 1555 1555 2.03 SSBOND 25 CYS B 743 CYS B 749 1555 1555 2.03 SSBOND 26 CYS B 840 CYS B 851 1555 1555 2.03 SSBOND 27 CYS B 1032 CYS B 1043 1555 1555 2.03 SSBOND 28 CYS B 1082 CYS B 1126 1555 1555 2.03 SSBOND 29 CYS C 131 CYS C 166 1555 1555 2.03 SSBOND 30 CYS C 291 CYS C 301 1555 1555 2.03 SSBOND 31 CYS C 336 CYS C 361 1555 1555 2.03 SSBOND 32 CYS C 379 CYS C 432 1555 1555 2.03 SSBOND 33 CYS C 391 CYS C 525 1555 1555 2.03 SSBOND 34 CYS C 480 CYS C 488 1555 1555 2.03 SSBOND 35 CYS C 538 CYS C 590 1555 1555 2.03 SSBOND 36 CYS C 617 CYS C 649 1555 1555 2.03 SSBOND 37 CYS C 662 CYS C 671 1555 1555 2.03 SSBOND 38 CYS C 738 CYS C 760 1555 1555 2.03 SSBOND 39 CYS C 743 CYS C 749 1555 1555 2.03 SSBOND 40 CYS C 840 CYS C 851 1555 1555 2.03 SSBOND 41 CYS C 1032 CYS C 1043 1555 1555 2.03 SSBOND 42 CYS C 1082 CYS C 1126 1555 1555 2.03 LINK ND2 ASN A 61 C1 NAG A1301 1555 1555 1.44 LINK ND2 ASN A 122 C1 NAG A1302 1555 1555 1.44 LINK ND2 ASN A 234 C1 NAG A1312 1555 1555 1.44 LINK ND2 ASN A 282 C1 NAG A1303 1555 1555 1.44 LINK ND2 ASN A 331 C1 NAG A1304 1555 1555 1.44 LINK ND2 ASN A 343 C1 NAG A1305 1555 1555 1.44 LINK ND2 ASN A 616 C1 NAG A1306 1555 1555 1.45 LINK ND2 ASN A 709 C1 NAG A1307 1555 1555 1.44 LINK ND2 ASN A 717 C1 NAG D 1 1555 1555 1.44 LINK ND2 ASN A 801 C1 NAG A1308 1555 1555 1.44 LINK ND2 ASN A1074 C1 NAG A1309 1555 1555 1.44 LINK ND2 ASN A1098 C1 NAG A1310 1555 1555 1.44 LINK ND2 ASN A1134 C1 NAG A1311 1555 1555 1.44 LINK ND2 ASN B 61 C1 NAG B1301 1555 1555 1.44 LINK ND2 ASN B 282 C1 NAG B1302 1555 1555 1.44 LINK ND2 ASN B 616 C1 NAG B1303 1555 1555 1.44 LINK ND2 ASN B 709 C1 NAG B1304 1555 1555 1.44 LINK ND2 ASN B 717 C1 NAG E 1 1555 1555 1.44 LINK ND2 ASN B 801 C1 NAG B1305 1555 1555 1.44 LINK ND2 ASN B1074 C1 NAG B1306 1555 1555 1.45 LINK ND2 ASN B1098 C1 NAG B1307 1555 1555 1.44 LINK ND2 ASN B1134 C1 NAG B1308 1555 1555 1.44 LINK ND2 ASN C 61 C1 NAG C1301 1555 1555 1.45 LINK ND2 ASN C 234 C1 NAG C1302 1555 1555 1.44 LINK ND2 ASN C 282 C1 NAG C1303 1555 1555 1.44 LINK ND2 ASN C 616 C1 NAG C1304 1555 1555 1.44 LINK ND2 ASN C 709 C1 NAG C1305 1555 1555 1.44 LINK ND2 ASN C 717 C1 NAG F 1 1555 1555 1.44 LINK ND2 ASN C 801 C1 NAG G 1 1555 1555 1.44 LINK ND2 ASN C1074 C1 NAG C1306 1555 1555 1.44 LINK ND2 ASN C1098 C1 NAG C1307 1555 1555 1.44 LINK ND2 ASN C1134 C1 NAG C1308 1555 1555 1.44 LINK O4 NAG D 1 C1 NAG D 2 1555 1555 1.44 LINK O4 NAG E 1 C1 NAG E 2 1555 1555 1.44 LINK O4 NAG F 1 C1 NAG F 2 1555 1555 1.44 LINK O4 NAG G 1 C1 NAG G 2 1555 1555 1.45 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000