data_4MIA # _entry.id 4MIA # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.397 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code _database_2.pdbx_database_accession _database_2.pdbx_DOI PDB 4MIA pdb_00004mia 10.2210/pdb4mia/pdb RCSB RCSB081944 ? ? WWPDB D_1000081944 ? ? # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2014-05-07 2 'Structure model' 1 1 2024-10-16 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? _pdbx_audit_revision_details.details ? # loop_ _pdbx_audit_revision_group.ordinal _pdbx_audit_revision_group.revision_ordinal _pdbx_audit_revision_group.data_content_type _pdbx_audit_revision_group.group 1 2 'Structure model' 'Data collection' 2 2 'Structure model' 'Database references' 3 2 'Structure model' 'Derived calculations' 4 2 'Structure model' 'Structure summary' # loop_ _pdbx_audit_revision_category.ordinal _pdbx_audit_revision_category.revision_ordinal _pdbx_audit_revision_category.data_content_type _pdbx_audit_revision_category.category 1 2 'Structure model' chem_comp_atom 2 2 'Structure model' chem_comp_bond 3 2 'Structure model' database_2 4 2 'Structure model' pdbx_entry_details 5 2 'Structure model' pdbx_modification_feature 6 2 'Structure model' struct_ref_seq_dif 7 2 'Structure model' struct_site # loop_ _pdbx_audit_revision_item.ordinal _pdbx_audit_revision_item.revision_ordinal _pdbx_audit_revision_item.data_content_type _pdbx_audit_revision_item.item 1 2 'Structure model' '_database_2.pdbx_DOI' 2 2 'Structure model' '_database_2.pdbx_database_accession' 3 2 'Structure model' '_struct_ref_seq_dif.details' 4 2 'Structure model' '_struct_site.pdbx_auth_asym_id' 5 2 'Structure model' '_struct_site.pdbx_auth_comp_id' 6 2 'Structure model' '_struct_site.pdbx_auth_seq_id' # _pdbx_database_status.entry_id 4MIA _pdbx_database_status.deposit_site RCSB _pdbx_database_status.process_site RCSB _pdbx_database_status.recvd_initial_deposition_date 2013-08-30 _pdbx_database_status.status_code REL _pdbx_database_status.status_code_sf REL _pdbx_database_status.status_code_mr ? _pdbx_database_status.SG_entry ? _pdbx_database_status.status_code_cs ? _pdbx_database_status.methods_development_category ? _pdbx_database_status.pdb_format_compatible Y _pdbx_database_status.status_code_nmr_data ? # loop_ _pdbx_database_related.db_name _pdbx_database_related.db_id _pdbx_database_related.details _pdbx_database_related.content_type PDB 4MIB . unspecified PDB 4MK7 . unspecified PDB 4MK8 . unspecified PDB 4MK9 . unspecified PDB 4MKA . unspecified PDB 4MKB . unspecified # loop_ _audit_author.name _audit_author.pdbx_ordinal 'Harris, S.F.' 1 'Villasenor, A.G.' 2 # _citation.id primary _citation.title ;Discovery of N-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymerase. ; _citation.journal_abbrev J.Med.Chem. _citation.journal_volume 57 _citation.page_first 1914 _citation.page_last 1931 _citation.year 2014 _citation.journal_id_ASTM JMCMAR _citation.country US _citation.journal_id_ISSN 0022-2623 _citation.journal_id_CSD 0151 _citation.book_publisher ? _citation.pdbx_database_id_PubMed 24195700 _citation.pdbx_database_id_DOI 10.1021/jm401329s # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal _citation_author.identifier_ORCID primary 'Talamas, F.X.' 1 ? primary 'Abbot, S.C.' 2 ? primary 'Anand, S.' 3 ? primary 'Brameld, K.A.' 4 ? primary 'Carter, D.S.' 5 ? primary 'Chen, J.' 6 ? primary 'Davis, D.' 7 ? primary 'de Vicente, J.' 8 ? primary 'Fung, A.D.' 9 ? primary 'Gong, L.' 10 ? primary 'Harris, S.F.' 11 ? primary 'Inbar, P.' 12 ? primary 'Labadie, S.S.' 13 ? primary 'Lee, E.K.' 14 ? primary 'Lemoine, R.' 15 ? primary 'Le Pogam, S.' 16 ? primary 'Leveque, V.' 17 ? primary 'Li, J.' 18 ? primary 'McIntosh, J.' 19 ? primary 'Najera, I.' 20 ? primary 'Park, J.' 21 ? primary 'Railkar, A.' 22 ? primary 'Rajyaguru, S.' 23 ? primary 'Sangi, M.' 24 ? primary 'Schoenfeld, R.C.' 25 ? primary 'Staben, L.R.' 26 ? primary 'Tan, Y.' 27 ? primary 'Taygerly, J.P.' 28 ? primary 'Villasenor, A.G.' 29 ? primary 'Weller, P.E.' 30 ? # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer man 'RNA-directed RNA polymerase' 63354.719 2 2.7.7.48 ? 'UNP RESIDUES 2421-2989' ? 2 non-polymer syn 'ZINC ION' 65.409 2 ? ? ? ? 3 non-polymer syn 'N-{4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-2,5-dihydropyridin-3-yl)quinolin-3-yl]phenyl}methanesulfonamide' 507.601 2 ? ? ? ? 4 water nat water 18.015 230 ? ? ? ? # _entity_name_com.entity_id 1 _entity_name_com.name 'NS5B, p68' # _entity_poly.entity_id 1 _entity_poly.type 'polypeptide(L)' _entity_poly.nstd_linkage no _entity_poly.nstd_monomer no _entity_poly.pdbx_seq_one_letter_code ;HMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRSAGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKA KLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNEVFCVQPEKGGRKPARLI VFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQYSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIY QCCDLAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKASAACRAAKLQDCTMLVNGDDL VVICESAGTQEDAASLRVFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETA RHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPG EINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASRLDLSGWFVAGYSGGDI YHSLSRARPR ; _entity_poly.pdbx_seq_one_letter_code_can ;HMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRSAGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKA KLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNEVFCVQPEKGGRKPARLI VFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQYSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIY QCCDLAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKASAACRAAKLQDCTMLVNGDDL VVICESAGTQEDAASLRVFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETA RHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPG EINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASRLDLSGWFVAGYSGGDI YHSLSRARPR ; _entity_poly.pdbx_strand_id A,B _entity_poly.pdbx_target_identifier ? # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 2 'ZINC ION' ZN 3 'N-{4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-2,5-dihydropyridin-3-yl)quinolin-3-yl]phenyl}methanesulfonamide' 28L 4 water HOH # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 HIS n 1 2 MET n 1 3 SER n 1 4 TYR n 1 5 THR n 1 6 TRP n 1 7 THR n 1 8 GLY n 1 9 ALA n 1 10 LEU n 1 11 ILE n 1 12 THR n 1 13 PRO n 1 14 CYS n 1 15 ALA n 1 16 ALA n 1 17 GLU n 1 18 GLU n 1 19 SER n 1 20 LYS n 1 21 LEU n 1 22 PRO n 1 23 ILE n 1 24 ASN n 1 25 ALA n 1 26 LEU n 1 27 SER n 1 28 ASN n 1 29 SER n 1 30 LEU n 1 31 LEU n 1 32 ARG n 1 33 HIS n 1 34 HIS n 1 35 ASN n 1 36 MET n 1 37 VAL n 1 38 TYR n 1 39 ALA n 1 40 THR n 1 41 THR n 1 42 SER n 1 43 ARG n 1 44 SER n 1 45 ALA n 1 46 GLY n 1 47 LEU n 1 48 ARG n 1 49 GLN n 1 50 LYS n 1 51 LYS n 1 52 VAL n 1 53 THR n 1 54 PHE n 1 55 ASP n 1 56 ARG n 1 57 LEU n 1 58 GLN n 1 59 VAL n 1 60 LEU n 1 61 ASP n 1 62 ASP n 1 63 HIS n 1 64 TYR n 1 65 ARG n 1 66 ASP n 1 67 VAL n 1 68 LEU n 1 69 LYS n 1 70 GLU n 1 71 MET n 1 72 LYS n 1 73 ALA n 1 74 LYS n 1 75 ALA n 1 76 SER n 1 77 THR n 1 78 VAL n 1 79 LYS n 1 80 ALA n 1 81 LYS n 1 82 LEU n 1 83 LEU n 1 84 SER n 1 85 VAL n 1 86 GLU n 1 87 GLU n 1 88 ALA n 1 89 CYS n 1 90 LYS n 1 91 LEU n 1 92 THR n 1 93 PRO n 1 94 PRO n 1 95 HIS n 1 96 SER n 1 97 ALA n 1 98 LYS n 1 99 SER n 1 100 LYS n 1 101 PHE n 1 102 GLY n 1 103 TYR n 1 104 GLY n 1 105 ALA n 1 106 LYS n 1 107 ASP n 1 108 VAL n 1 109 ARG n 1 110 ASN n 1 111 LEU n 1 112 SER n 1 113 SER n 1 114 LYS n 1 115 ALA n 1 116 VAL n 1 117 ASN n 1 118 HIS n 1 119 ILE n 1 120 HIS n 1 121 SER n 1 122 VAL n 1 123 TRP n 1 124 LYS n 1 125 ASP n 1 126 LEU n 1 127 LEU n 1 128 GLU n 1 129 ASP n 1 130 THR n 1 131 VAL n 1 132 THR n 1 133 PRO n 1 134 ILE n 1 135 ASP n 1 136 THR n 1 137 THR n 1 138 ILE n 1 139 MET n 1 140 ALA n 1 141 LYS n 1 142 ASN n 1 143 GLU n 1 144 VAL n 1 145 PHE n 1 146 CYS n 1 147 VAL n 1 148 GLN n 1 149 PRO n 1 150 GLU n 1 151 LYS n 1 152 GLY n 1 153 GLY n 1 154 ARG n 1 155 LYS n 1 156 PRO n 1 157 ALA n 1 158 ARG n 1 159 LEU n 1 160 ILE n 1 161 VAL n 1 162 PHE n 1 163 PRO n 1 164 ASP n 1 165 LEU n 1 166 GLY n 1 167 VAL n 1 168 ARG n 1 169 VAL n 1 170 CYS n 1 171 GLU n 1 172 LYS n 1 173 MET n 1 174 ALA n 1 175 LEU n 1 176 TYR n 1 177 ASP n 1 178 VAL n 1 179 VAL n 1 180 SER n 1 181 THR n 1 182 LEU n 1 183 PRO n 1 184 GLN n 1 185 VAL n 1 186 VAL n 1 187 MET n 1 188 GLY n 1 189 SER n 1 190 SER n 1 191 TYR n 1 192 GLY n 1 193 PHE n 1 194 GLN n 1 195 TYR n 1 196 SER n 1 197 PRO n 1 198 GLY n 1 199 GLN n 1 200 ARG n 1 201 VAL n 1 202 GLU n 1 203 PHE n 1 204 LEU n 1 205 VAL n 1 206 ASN n 1 207 THR n 1 208 TRP n 1 209 LYS n 1 210 SER n 1 211 LYS n 1 212 LYS n 1 213 ASN n 1 214 PRO n 1 215 MET n 1 216 GLY n 1 217 PHE n 1 218 SER n 1 219 TYR n 1 220 ASP n 1 221 THR n 1 222 ARG n 1 223 CYS n 1 224 PHE n 1 225 ASP n 1 226 SER n 1 227 THR n 1 228 VAL n 1 229 THR n 1 230 GLU n 1 231 ASN n 1 232 ASP n 1 233 ILE n 1 234 ARG n 1 235 VAL n 1 236 GLU n 1 237 GLU n 1 238 SER n 1 239 ILE n 1 240 TYR n 1 241 GLN n 1 242 CYS n 1 243 CYS n 1 244 ASP n 1 245 LEU n 1 246 ALA n 1 247 PRO n 1 248 GLU n 1 249 ALA n 1 250 ARG n 1 251 GLN n 1 252 ALA n 1 253 ILE n 1 254 LYS n 1 255 SER n 1 256 LEU n 1 257 THR n 1 258 GLU n 1 259 ARG n 1 260 LEU n 1 261 TYR n 1 262 ILE n 1 263 GLY n 1 264 GLY n 1 265 PRO n 1 266 LEU n 1 267 THR n 1 268 ASN n 1 269 SER n 1 270 LYS n 1 271 GLY n 1 272 GLN n 1 273 ASN n 1 274 CYS n 1 275 GLY n 1 276 TYR n 1 277 ARG n 1 278 ARG n 1 279 CYS n 1 280 ARG n 1 281 ALA n 1 282 SER n 1 283 GLY n 1 284 VAL n 1 285 LEU n 1 286 THR n 1 287 THR n 1 288 SER n 1 289 CYS n 1 290 GLY n 1 291 ASN n 1 292 THR n 1 293 LEU n 1 294 THR n 1 295 CYS n 1 296 TYR n 1 297 LEU n 1 298 LYS n 1 299 ALA n 1 300 SER n 1 301 ALA n 1 302 ALA n 1 303 CYS n 1 304 ARG n 1 305 ALA n 1 306 ALA n 1 307 LYS n 1 308 LEU n 1 309 GLN n 1 310 ASP n 1 311 CYS n 1 312 THR n 1 313 MET n 1 314 LEU n 1 315 VAL n 1 316 ASN n 1 317 GLY n 1 318 ASP n 1 319 ASP n 1 320 LEU n 1 321 VAL n 1 322 VAL n 1 323 ILE n 1 324 CYS n 1 325 GLU n 1 326 SER n 1 327 ALA n 1 328 GLY n 1 329 THR n 1 330 GLN n 1 331 GLU n 1 332 ASP n 1 333 ALA n 1 334 ALA n 1 335 SER n 1 336 LEU n 1 337 ARG n 1 338 VAL n 1 339 PHE n 1 340 THR n 1 341 GLU n 1 342 ALA n 1 343 MET n 1 344 THR n 1 345 ARG n 1 346 TYR n 1 347 SER n 1 348 ALA n 1 349 PRO n 1 350 PRO n 1 351 GLY n 1 352 ASP n 1 353 PRO n 1 354 PRO n 1 355 GLN n 1 356 PRO n 1 357 GLU n 1 358 TYR n 1 359 ASP n 1 360 LEU n 1 361 GLU n 1 362 LEU n 1 363 ILE n 1 364 THR n 1 365 SER n 1 366 CYS n 1 367 SER n 1 368 SER n 1 369 ASN n 1 370 VAL n 1 371 SER n 1 372 VAL n 1 373 ALA n 1 374 HIS n 1 375 ASP n 1 376 ALA n 1 377 SER n 1 378 GLY n 1 379 LYS n 1 380 ARG n 1 381 VAL n 1 382 TYR n 1 383 TYR n 1 384 LEU n 1 385 THR n 1 386 ARG n 1 387 ASP n 1 388 PRO n 1 389 THR n 1 390 THR n 1 391 PRO n 1 392 LEU n 1 393 ALA n 1 394 ARG n 1 395 ALA n 1 396 ALA n 1 397 TRP n 1 398 GLU n 1 399 THR n 1 400 ALA n 1 401 ARG n 1 402 HIS n 1 403 THR n 1 404 PRO n 1 405 VAL n 1 406 ASN n 1 407 SER n 1 408 TRP n 1 409 LEU n 1 410 GLY n 1 411 ASN n 1 412 ILE n 1 413 ILE n 1 414 MET n 1 415 TYR n 1 416 ALA n 1 417 PRO n 1 418 THR n 1 419 LEU n 1 420 TRP n 1 421 ALA n 1 422 ARG n 1 423 MET n 1 424 ILE n 1 425 LEU n 1 426 MET n 1 427 THR n 1 428 HIS n 1 429 PHE n 1 430 PHE n 1 431 SER n 1 432 ILE n 1 433 LEU n 1 434 LEU n 1 435 ALA n 1 436 GLN n 1 437 GLU n 1 438 GLN n 1 439 LEU n 1 440 GLU n 1 441 LYS n 1 442 ALA n 1 443 LEU n 1 444 ASP n 1 445 CYS n 1 446 GLN n 1 447 ILE n 1 448 TYR n 1 449 GLY n 1 450 ALA n 1 451 CYS n 1 452 TYR n 1 453 SER n 1 454 ILE n 1 455 GLU n 1 456 PRO n 1 457 LEU n 1 458 ASP n 1 459 LEU n 1 460 PRO n 1 461 GLN n 1 462 ILE n 1 463 ILE n 1 464 GLU n 1 465 ARG n 1 466 LEU n 1 467 HIS n 1 468 GLY n 1 469 LEU n 1 470 SER n 1 471 ALA n 1 472 PHE n 1 473 SER n 1 474 LEU n 1 475 HIS n 1 476 SER n 1 477 TYR n 1 478 SER n 1 479 PRO n 1 480 GLY n 1 481 GLU n 1 482 ILE n 1 483 ASN n 1 484 ARG n 1 485 VAL n 1 486 ALA n 1 487 SER n 1 488 CYS n 1 489 LEU n 1 490 ARG n 1 491 LYS n 1 492 LEU n 1 493 GLY n 1 494 VAL n 1 495 PRO n 1 496 PRO n 1 497 LEU n 1 498 ARG n 1 499 VAL n 1 500 TRP n 1 501 ARG n 1 502 HIS n 1 503 ARG n 1 504 ALA n 1 505 ARG n 1 506 SER n 1 507 VAL n 1 508 ARG n 1 509 ALA n 1 510 ARG n 1 511 LEU n 1 512 LEU n 1 513 SER n 1 514 GLN n 1 515 GLY n 1 516 GLY n 1 517 ARG n 1 518 ALA n 1 519 ALA n 1 520 THR n 1 521 CYS n 1 522 GLY n 1 523 LYS n 1 524 TYR n 1 525 LEU n 1 526 PHE n 1 527 ASN n 1 528 TRP n 1 529 ALA n 1 530 VAL n 1 531 LYS n 1 532 THR n 1 533 LYS n 1 534 LEU n 1 535 LYS n 1 536 LEU n 1 537 THR n 1 538 PRO n 1 539 ILE n 1 540 PRO n 1 541 ALA n 1 542 ALA n 1 543 SER n 1 544 ARG n 1 545 LEU n 1 546 ASP n 1 547 LEU n 1 548 SER n 1 549 GLY n 1 550 TRP n 1 551 PHE n 1 552 VAL n 1 553 ALA n 1 554 GLY n 1 555 TYR n 1 556 SER n 1 557 GLY n 1 558 GLY n 1 559 ASP n 1 560 ILE n 1 561 TYR n 1 562 HIS n 1 563 SER n 1 564 LEU n 1 565 SER n 1 566 ARG n 1 567 ALA n 1 568 ARG n 1 569 PRO n 1 570 ARG n # _entity_src_gen.entity_id 1 _entity_src_gen.pdbx_src_id 1 _entity_src_gen.pdbx_alt_source_flag sample _entity_src_gen.pdbx_seq_type ? _entity_src_gen.pdbx_beg_seq_num ? _entity_src_gen.pdbx_end_seq_num ? _entity_src_gen.gene_src_common_name HCV _entity_src_gen.gene_src_genus ? _entity_src_gen.pdbx_gene_src_gene NS5B _entity_src_gen.gene_src_species ? _entity_src_gen.gene_src_strain '1b BK' _entity_src_gen.gene_src_tissue ? _entity_src_gen.gene_src_tissue_fraction ? _entity_src_gen.gene_src_details ? _entity_src_gen.pdbx_gene_src_fragment ? _entity_src_gen.pdbx_gene_src_scientific_name 'Hepatitis C virus' _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 11105 _entity_src_gen.pdbx_gene_src_variant ? _entity_src_gen.pdbx_gene_src_cell_line ? _entity_src_gen.pdbx_gene_src_atcc ? _entity_src_gen.pdbx_gene_src_organ ? _entity_src_gen.pdbx_gene_src_organelle ? _entity_src_gen.pdbx_gene_src_cell ? _entity_src_gen.pdbx_gene_src_cellular_location ? _entity_src_gen.host_org_common_name ? _entity_src_gen.pdbx_host_org_scientific_name 'Escherichia coli' _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 562 _entity_src_gen.host_org_genus ? _entity_src_gen.pdbx_host_org_gene ? _entity_src_gen.pdbx_host_org_organ ? _entity_src_gen.host_org_species ? _entity_src_gen.pdbx_host_org_tissue ? _entity_src_gen.pdbx_host_org_tissue_fraction ? _entity_src_gen.pdbx_host_org_strain ? _entity_src_gen.pdbx_host_org_variant ? _entity_src_gen.pdbx_host_org_cell_line ? _entity_src_gen.pdbx_host_org_atcc ? _entity_src_gen.pdbx_host_org_culture_collection ? _entity_src_gen.pdbx_host_org_cell ? _entity_src_gen.pdbx_host_org_organelle ? _entity_src_gen.pdbx_host_org_cellular_location ? _entity_src_gen.pdbx_host_org_vector_type ? _entity_src_gen.pdbx_host_org_vector ? _entity_src_gen.host_org_details ? _entity_src_gen.expression_system_id ? _entity_src_gen.plasmid_name ? _entity_src_gen.plasmid_details ? _entity_src_gen.pdbx_description ? # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight 28L non-polymer . 'N-{4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-2,5-dihydropyridin-3-yl)quinolin-3-yl]phenyl}methanesulfonamide' ? 'C27 H29 N3 O5 S' 507.601 ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HOH non-polymer . WATER ? 'H2 O' 18.015 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 ZN non-polymer . 'ZINC ION' ? 'Zn 2' 65.409 # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 HIS 1 1 1 HIS HIS A . n A 1 2 MET 2 2 2 MET MET A . n A 1 3 SER 3 3 3 SER SER A . n A 1 4 TYR 4 4 4 TYR TYR A . n A 1 5 THR 5 5 5 THR THR A . n A 1 6 TRP 6 6 6 TRP TRP A . n A 1 7 THR 7 7 7 THR THR A . n A 1 8 GLY 8 8 8 GLY GLY A . n A 1 9 ALA 9 9 9 ALA ALA A . n A 1 10 LEU 10 10 10 LEU LEU A . n A 1 11 ILE 11 11 11 ILE ILE A . n A 1 12 THR 12 12 12 THR THR A . n A 1 13 PRO 13 13 13 PRO PRO A . n A 1 14 CYS 14 14 14 CYS CYS A . n A 1 15 ALA 15 15 15 ALA ALA A . n A 1 16 ALA 16 16 16 ALA ALA A . n A 1 17 GLU 17 17 17 GLU GLU A . n A 1 18 GLU 18 18 18 GLU GLU A . n A 1 19 SER 19 19 19 SER SER A . n A 1 20 LYS 20 20 20 LYS LYS A . n A 1 21 LEU 21 21 21 LEU LEU A . n A 1 22 PRO 22 22 22 PRO PRO A . n A 1 23 ILE 23 23 23 ILE ILE A . n A 1 24 ASN 24 24 24 ASN ASN A . n A 1 25 ALA 25 25 25 ALA ALA A . n A 1 26 LEU 26 26 26 LEU LEU A . n A 1 27 SER 27 27 27 SER SER A . n A 1 28 ASN 28 28 28 ASN ASN A . n A 1 29 SER 29 29 29 SER SER A . n A 1 30 LEU 30 30 30 LEU LEU A . n A 1 31 LEU 31 31 31 LEU LEU A . n A 1 32 ARG 32 32 32 ARG ARG A . n A 1 33 HIS 33 33 33 HIS HIS A . n A 1 34 HIS 34 34 34 HIS HIS A . n A 1 35 ASN 35 35 35 ASN ASN A . n A 1 36 MET 36 36 36 MET MET A . n A 1 37 VAL 37 37 37 VAL VAL A . n A 1 38 TYR 38 38 38 TYR TYR A . n A 1 39 ALA 39 39 39 ALA ALA A . n A 1 40 THR 40 40 40 THR THR A . n A 1 41 THR 41 41 41 THR THR A . n A 1 42 SER 42 42 42 SER SER A . n A 1 43 ARG 43 43 43 ARG ARG A . n A 1 44 SER 44 44 44 SER SER A . n A 1 45 ALA 45 45 45 ALA ALA A . n A 1 46 GLY 46 46 46 GLY GLY A . n A 1 47 LEU 47 47 47 LEU LEU A . n A 1 48 ARG 48 48 48 ARG ARG A . n A 1 49 GLN 49 49 49 GLN GLN A . n A 1 50 LYS 50 50 50 LYS LYS A . n A 1 51 LYS 51 51 51 LYS LYS A . n A 1 52 VAL 52 52 52 VAL VAL A . n A 1 53 THR 53 53 53 THR THR A . n A 1 54 PHE 54 54 54 PHE PHE A . n A 1 55 ASP 55 55 55 ASP ASP A . n A 1 56 ARG 56 56 56 ARG ARG A . n A 1 57 LEU 57 57 57 LEU LEU A . n A 1 58 GLN 58 58 58 GLN GLN A . n A 1 59 VAL 59 59 59 VAL VAL A . n A 1 60 LEU 60 60 60 LEU LEU A . n A 1 61 ASP 61 61 61 ASP ASP A . n A 1 62 ASP 62 62 62 ASP ASP A . n A 1 63 HIS 63 63 63 HIS HIS A . n A 1 64 TYR 64 64 64 TYR TYR A . n A 1 65 ARG 65 65 65 ARG ARG A . n A 1 66 ASP 66 66 66 ASP ASP A . n A 1 67 VAL 67 67 67 VAL VAL A . n A 1 68 LEU 68 68 68 LEU LEU A . n A 1 69 LYS 69 69 69 LYS LYS A . n A 1 70 GLU 70 70 70 GLU GLU A . n A 1 71 MET 71 71 71 MET MET A . n A 1 72 LYS 72 72 72 LYS LYS A . n A 1 73 ALA 73 73 73 ALA ALA A . n A 1 74 LYS 74 74 74 LYS LYS A . n A 1 75 ALA 75 75 75 ALA ALA A . n A 1 76 SER 76 76 76 SER SER A . n A 1 77 THR 77 77 77 THR THR A . n A 1 78 VAL 78 78 78 VAL VAL A . n A 1 79 LYS 79 79 79 LYS LYS A . n A 1 80 ALA 80 80 80 ALA ALA A . n A 1 81 LYS 81 81 81 LYS LYS A . n A 1 82 LEU 82 82 82 LEU LEU A . n A 1 83 LEU 83 83 83 LEU LEU A . n A 1 84 SER 84 84 84 SER SER A . n A 1 85 VAL 85 85 85 VAL VAL A . n A 1 86 GLU 86 86 86 GLU GLU A . n A 1 87 GLU 87 87 87 GLU GLU A . n A 1 88 ALA 88 88 88 ALA ALA A . n A 1 89 CYS 89 89 89 CYS CYS A . n A 1 90 LYS 90 90 90 LYS LYS A . n A 1 91 LEU 91 91 91 LEU LEU A . n A 1 92 THR 92 92 92 THR THR A . n A 1 93 PRO 93 93 93 PRO PRO A . n A 1 94 PRO 94 94 94 PRO PRO A . n A 1 95 HIS 95 95 95 HIS HIS A . n A 1 96 SER 96 96 96 SER SER A . n A 1 97 ALA 97 97 97 ALA ALA A . n A 1 98 LYS 98 98 98 LYS LYS A . n A 1 99 SER 99 99 99 SER SER A . n A 1 100 LYS 100 100 100 LYS LYS A . n A 1 101 PHE 101 101 101 PHE PHE A . n A 1 102 GLY 102 102 102 GLY GLY A . n A 1 103 TYR 103 103 103 TYR TYR A . n A 1 104 GLY 104 104 104 GLY GLY A . n A 1 105 ALA 105 105 105 ALA ALA A . n A 1 106 LYS 106 106 106 LYS LYS A . n A 1 107 ASP 107 107 107 ASP ASP A . n A 1 108 VAL 108 108 108 VAL VAL A . n A 1 109 ARG 109 109 109 ARG ARG A . n A 1 110 ASN 110 110 110 ASN ASN A . n A 1 111 LEU 111 111 111 LEU LEU A . n A 1 112 SER 112 112 112 SER SER A . n A 1 113 SER 113 113 113 SER SER A . n A 1 114 LYS 114 114 114 LYS LYS A . n A 1 115 ALA 115 115 115 ALA ALA A . n A 1 116 VAL 116 116 116 VAL VAL A . n A 1 117 ASN 117 117 117 ASN ASN A . n A 1 118 HIS 118 118 118 HIS HIS A . n A 1 119 ILE 119 119 119 ILE ILE A . n A 1 120 HIS 120 120 120 HIS HIS A . n A 1 121 SER 121 121 121 SER SER A . n A 1 122 VAL 122 122 122 VAL VAL A . n A 1 123 TRP 123 123 123 TRP TRP A . n A 1 124 LYS 124 124 124 LYS LYS A . n A 1 125 ASP 125 125 125 ASP ASP A . n A 1 126 LEU 126 126 126 LEU LEU A . n A 1 127 LEU 127 127 127 LEU LEU A . n A 1 128 GLU 128 128 128 GLU GLU A . n A 1 129 ASP 129 129 129 ASP ASP A . n A 1 130 THR 130 130 130 THR THR A . n A 1 131 VAL 131 131 131 VAL VAL A . n A 1 132 THR 132 132 132 THR THR A . n A 1 133 PRO 133 133 133 PRO PRO A . n A 1 134 ILE 134 134 134 ILE ILE A . n A 1 135 ASP 135 135 135 ASP ASP A . n A 1 136 THR 136 136 136 THR THR A . n A 1 137 THR 137 137 137 THR THR A . n A 1 138 ILE 138 138 138 ILE ILE A . n A 1 139 MET 139 139 139 MET MET A . n A 1 140 ALA 140 140 140 ALA ALA A . n A 1 141 LYS 141 141 141 LYS LYS A . n A 1 142 ASN 142 142 142 ASN ASN A . n A 1 143 GLU 143 143 143 GLU GLU A . n A 1 144 VAL 144 144 144 VAL VAL A . n A 1 145 PHE 145 145 145 PHE PHE A . n A 1 146 CYS 146 146 146 CYS CYS A . n A 1 147 VAL 147 147 147 VAL VAL A . n A 1 148 GLN 148 148 148 GLN GLN A . n A 1 149 PRO 149 149 ? ? ? A . n A 1 150 GLU 150 150 ? ? ? A . n A 1 151 LYS 151 151 ? ? ? A . n A 1 152 GLY 152 152 ? ? ? A . n A 1 153 GLY 153 153 ? ? ? A . n A 1 154 ARG 154 154 154 ARG ARG A . n A 1 155 LYS 155 155 155 LYS LYS A . n A 1 156 PRO 156 156 156 PRO PRO A . n A 1 157 ALA 157 157 157 ALA ALA A . n A 1 158 ARG 158 158 158 ARG ARG A . n A 1 159 LEU 159 159 159 LEU LEU A . n A 1 160 ILE 160 160 160 ILE ILE A . n A 1 161 VAL 161 161 161 VAL VAL A . n A 1 162 PHE 162 162 162 PHE PHE A . n A 1 163 PRO 163 163 163 PRO PRO A . n A 1 164 ASP 164 164 164 ASP ASP A . n A 1 165 LEU 165 165 165 LEU LEU A . n A 1 166 GLY 166 166 166 GLY GLY A . n A 1 167 VAL 167 167 167 VAL VAL A . n A 1 168 ARG 168 168 168 ARG ARG A . n A 1 169 VAL 169 169 169 VAL VAL A . n A 1 170 CYS 170 170 170 CYS CYS A . n A 1 171 GLU 171 171 171 GLU GLU A . n A 1 172 LYS 172 172 172 LYS LYS A . n A 1 173 MET 173 173 173 MET MET A . n A 1 174 ALA 174 174 174 ALA ALA A . n A 1 175 LEU 175 175 175 LEU LEU A . n A 1 176 TYR 176 176 176 TYR TYR A . n A 1 177 ASP 177 177 177 ASP ASP A . n A 1 178 VAL 178 178 178 VAL VAL A . n A 1 179 VAL 179 179 179 VAL VAL A . n A 1 180 SER 180 180 180 SER SER A . n A 1 181 THR 181 181 181 THR THR A . n A 1 182 LEU 182 182 182 LEU LEU A . n A 1 183 PRO 183 183 183 PRO PRO A . n A 1 184 GLN 184 184 184 GLN GLN A . n A 1 185 VAL 185 185 185 VAL VAL A . n A 1 186 VAL 186 186 186 VAL VAL A . n A 1 187 MET 187 187 187 MET MET A . n A 1 188 GLY 188 188 188 GLY GLY A . n A 1 189 SER 189 189 189 SER SER A . n A 1 190 SER 190 190 190 SER SER A . n A 1 191 TYR 191 191 191 TYR TYR A . n A 1 192 GLY 192 192 192 GLY GLY A . n A 1 193 PHE 193 193 193 PHE PHE A . n A 1 194 GLN 194 194 194 GLN GLN A . n A 1 195 TYR 195 195 195 TYR TYR A . n A 1 196 SER 196 196 196 SER SER A . n A 1 197 PRO 197 197 197 PRO PRO A . n A 1 198 GLY 198 198 198 GLY GLY A . n A 1 199 GLN 199 199 199 GLN GLN A . n A 1 200 ARG 200 200 200 ARG ARG A . n A 1 201 VAL 201 201 201 VAL VAL A . n A 1 202 GLU 202 202 202 GLU GLU A . n A 1 203 PHE 203 203 203 PHE PHE A . n A 1 204 LEU 204 204 204 LEU LEU A . n A 1 205 VAL 205 205 205 VAL VAL A . n A 1 206 ASN 206 206 206 ASN ASN A . n A 1 207 THR 207 207 207 THR THR A . n A 1 208 TRP 208 208 208 TRP TRP A . n A 1 209 LYS 209 209 209 LYS LYS A . n A 1 210 SER 210 210 210 SER SER A . n A 1 211 LYS 211 211 211 LYS LYS A . n A 1 212 LYS 212 212 212 LYS LYS A . n A 1 213 ASN 213 213 213 ASN ASN A . n A 1 214 PRO 214 214 214 PRO PRO A . n A 1 215 MET 215 215 215 MET MET A . n A 1 216 GLY 216 216 216 GLY GLY A . n A 1 217 PHE 217 217 217 PHE PHE A . n A 1 218 SER 218 218 218 SER SER A . n A 1 219 TYR 219 219 219 TYR TYR A . n A 1 220 ASP 220 220 220 ASP ASP A . n A 1 221 THR 221 221 221 THR THR A . n A 1 222 ARG 222 222 222 ARG ARG A . n A 1 223 CYS 223 223 223 CYS CYS A . n A 1 224 PHE 224 224 224 PHE PHE A . n A 1 225 ASP 225 225 225 ASP ASP A . n A 1 226 SER 226 226 226 SER SER A . n A 1 227 THR 227 227 227 THR THR A . n A 1 228 VAL 228 228 228 VAL VAL A . n A 1 229 THR 229 229 229 THR THR A . n A 1 230 GLU 230 230 230 GLU GLU A . n A 1 231 ASN 231 231 231 ASN ASN A . n A 1 232 ASP 232 232 232 ASP ASP A . n A 1 233 ILE 233 233 233 ILE ILE A . n A 1 234 ARG 234 234 234 ARG ARG A . n A 1 235 VAL 235 235 235 VAL VAL A . n A 1 236 GLU 236 236 236 GLU GLU A . n A 1 237 GLU 237 237 237 GLU GLU A . n A 1 238 SER 238 238 238 SER SER A . n A 1 239 ILE 239 239 239 ILE ILE A . n A 1 240 TYR 240 240 240 TYR TYR A . n A 1 241 GLN 241 241 241 GLN GLN A . n A 1 242 CYS 242 242 242 CYS CYS A . n A 1 243 CYS 243 243 243 CYS CYS A . n A 1 244 ASP 244 244 244 ASP ASP A . n A 1 245 LEU 245 245 245 LEU LEU A . n A 1 246 ALA 246 246 246 ALA ALA A . n A 1 247 PRO 247 247 247 PRO PRO A . n A 1 248 GLU 248 248 248 GLU GLU A . n A 1 249 ALA 249 249 249 ALA ALA A . n A 1 250 ARG 250 250 250 ARG ARG A . n A 1 251 GLN 251 251 251 GLN GLN A . n A 1 252 ALA 252 252 252 ALA ALA A . n A 1 253 ILE 253 253 253 ILE ILE A . n A 1 254 LYS 254 254 254 LYS LYS A . n A 1 255 SER 255 255 255 SER SER A . n A 1 256 LEU 256 256 256 LEU LEU A . n A 1 257 THR 257 257 257 THR THR A . n A 1 258 GLU 258 258 258 GLU GLU A . n A 1 259 ARG 259 259 259 ARG ARG A . n A 1 260 LEU 260 260 260 LEU LEU A . n A 1 261 TYR 261 261 261 TYR TYR A . n A 1 262 ILE 262 262 262 ILE ILE A . n A 1 263 GLY 263 263 263 GLY GLY A . n A 1 264 GLY 264 264 264 GLY GLY A . n A 1 265 PRO 265 265 265 PRO PRO A . n A 1 266 LEU 266 266 266 LEU LEU A . n A 1 267 THR 267 267 267 THR THR A . n A 1 268 ASN 268 268 268 ASN ASN A . n A 1 269 SER 269 269 269 SER SER A . n A 1 270 LYS 270 270 270 LYS LYS A . n A 1 271 GLY 271 271 271 GLY GLY A . n A 1 272 GLN 272 272 272 GLN GLN A . n A 1 273 ASN 273 273 273 ASN ASN A . n A 1 274 CYS 274 274 274 CYS CYS A . n A 1 275 GLY 275 275 275 GLY GLY A . n A 1 276 TYR 276 276 276 TYR TYR A . n A 1 277 ARG 277 277 277 ARG ARG A . n A 1 278 ARG 278 278 278 ARG ARG A . n A 1 279 CYS 279 279 279 CYS CYS A . n A 1 280 ARG 280 280 280 ARG ARG A . n A 1 281 ALA 281 281 281 ALA ALA A . n A 1 282 SER 282 282 282 SER SER A . n A 1 283 GLY 283 283 283 GLY GLY A . n A 1 284 VAL 284 284 284 VAL VAL A . n A 1 285 LEU 285 285 285 LEU LEU A . n A 1 286 THR 286 286 286 THR THR A . n A 1 287 THR 287 287 287 THR THR A . n A 1 288 SER 288 288 288 SER SER A . n A 1 289 CYS 289 289 289 CYS CYS A . n A 1 290 GLY 290 290 290 GLY GLY A . n A 1 291 ASN 291 291 291 ASN ASN A . n A 1 292 THR 292 292 292 THR THR A . n A 1 293 LEU 293 293 293 LEU LEU A . n A 1 294 THR 294 294 294 THR THR A . n A 1 295 CYS 295 295 295 CYS CYS A . n A 1 296 TYR 296 296 296 TYR TYR A . n A 1 297 LEU 297 297 297 LEU LEU A . n A 1 298 LYS 298 298 298 LYS LYS A . n A 1 299 ALA 299 299 299 ALA ALA A . n A 1 300 SER 300 300 300 SER SER A . n A 1 301 ALA 301 301 301 ALA ALA A . n A 1 302 ALA 302 302 302 ALA ALA A . n A 1 303 CYS 303 303 303 CYS CYS A . n A 1 304 ARG 304 304 304 ARG ARG A . n A 1 305 ALA 305 305 305 ALA ALA A . n A 1 306 ALA 306 306 306 ALA ALA A . n A 1 307 LYS 307 307 307 LYS LYS A . n A 1 308 LEU 308 308 308 LEU LEU A . n A 1 309 GLN 309 309 309 GLN GLN A . n A 1 310 ASP 310 310 310 ASP ASP A . n A 1 311 CYS 311 311 311 CYS CYS A . n A 1 312 THR 312 312 312 THR THR A . n A 1 313 MET 313 313 313 MET MET A . n A 1 314 LEU 314 314 314 LEU LEU A . n A 1 315 VAL 315 315 315 VAL VAL A . n A 1 316 ASN 316 316 316 ASN ASN A . n A 1 317 GLY 317 317 317 GLY GLY A . n A 1 318 ASP 318 318 318 ASP ASP A . n A 1 319 ASP 319 319 319 ASP ASP A . n A 1 320 LEU 320 320 320 LEU LEU A . n A 1 321 VAL 321 321 321 VAL VAL A . n A 1 322 VAL 322 322 322 VAL VAL A . n A 1 323 ILE 323 323 323 ILE ILE A . n A 1 324 CYS 324 324 324 CYS CYS A . n A 1 325 GLU 325 325 325 GLU GLU A . n A 1 326 SER 326 326 326 SER SER A . n A 1 327 ALA 327 327 327 ALA ALA A . n A 1 328 GLY 328 328 328 GLY GLY A . n A 1 329 THR 329 329 329 THR THR A . n A 1 330 GLN 330 330 330 GLN GLN A . n A 1 331 GLU 331 331 331 GLU GLU A . n A 1 332 ASP 332 332 332 ASP ASP A . n A 1 333 ALA 333 333 333 ALA ALA A . n A 1 334 ALA 334 334 334 ALA ALA A . n A 1 335 SER 335 335 335 SER SER A . n A 1 336 LEU 336 336 336 LEU LEU A . n A 1 337 ARG 337 337 337 ARG ARG A . n A 1 338 VAL 338 338 338 VAL VAL A . n A 1 339 PHE 339 339 339 PHE PHE A . n A 1 340 THR 340 340 340 THR THR A . n A 1 341 GLU 341 341 341 GLU GLU A . n A 1 342 ALA 342 342 342 ALA ALA A . n A 1 343 MET 343 343 343 MET MET A . n A 1 344 THR 344 344 344 THR THR A . n A 1 345 ARG 345 345 345 ARG ARG A . n A 1 346 TYR 346 346 346 TYR TYR A . n A 1 347 SER 347 347 347 SER SER A . n A 1 348 ALA 348 348 348 ALA ALA A . n A 1 349 PRO 349 349 349 PRO PRO A . n A 1 350 PRO 350 350 350 PRO PRO A . n A 1 351 GLY 351 351 351 GLY GLY A . n A 1 352 ASP 352 352 352 ASP ASP A . n A 1 353 PRO 353 353 353 PRO PRO A . n A 1 354 PRO 354 354 354 PRO PRO A . n A 1 355 GLN 355 355 355 GLN GLN A . n A 1 356 PRO 356 356 356 PRO PRO A . n A 1 357 GLU 357 357 357 GLU GLU A . n A 1 358 TYR 358 358 358 TYR TYR A . n A 1 359 ASP 359 359 359 ASP ASP A . n A 1 360 LEU 360 360 360 LEU LEU A . n A 1 361 GLU 361 361 361 GLU GLU A . n A 1 362 LEU 362 362 362 LEU LEU A . n A 1 363 ILE 363 363 363 ILE ILE A . n A 1 364 THR 364 364 364 THR THR A . n A 1 365 SER 365 365 365 SER SER A . n A 1 366 CYS 366 366 366 CYS CYS A . n A 1 367 SER 367 367 367 SER SER A . n A 1 368 SER 368 368 368 SER SER A . n A 1 369 ASN 369 369 369 ASN ASN A . n A 1 370 VAL 370 370 370 VAL VAL A . n A 1 371 SER 371 371 371 SER SER A . n A 1 372 VAL 372 372 372 VAL VAL A . n A 1 373 ALA 373 373 373 ALA ALA A . n A 1 374 HIS 374 374 374 HIS HIS A . n A 1 375 ASP 375 375 375 ASP ASP A . n A 1 376 ALA 376 376 376 ALA ALA A . n A 1 377 SER 377 377 377 SER SER A . n A 1 378 GLY 378 378 378 GLY GLY A . n A 1 379 LYS 379 379 379 LYS LYS A . n A 1 380 ARG 380 380 380 ARG ARG A . n A 1 381 VAL 381 381 381 VAL VAL A . n A 1 382 TYR 382 382 382 TYR TYR A . n A 1 383 TYR 383 383 383 TYR TYR A . n A 1 384 LEU 384 384 384 LEU LEU A . n A 1 385 THR 385 385 385 THR THR A . n A 1 386 ARG 386 386 386 ARG ARG A . n A 1 387 ASP 387 387 387 ASP ASP A . n A 1 388 PRO 388 388 388 PRO PRO A . n A 1 389 THR 389 389 389 THR THR A . n A 1 390 THR 390 390 390 THR THR A . n A 1 391 PRO 391 391 391 PRO PRO A . n A 1 392 LEU 392 392 392 LEU LEU A . n A 1 393 ALA 393 393 393 ALA ALA A . n A 1 394 ARG 394 394 394 ARG ARG A . n A 1 395 ALA 395 395 395 ALA ALA A . n A 1 396 ALA 396 396 396 ALA ALA A . n A 1 397 TRP 397 397 397 TRP TRP A . n A 1 398 GLU 398 398 398 GLU GLU A . n A 1 399 THR 399 399 399 THR THR A . n A 1 400 ALA 400 400 400 ALA ALA A . n A 1 401 ARG 401 401 401 ARG ARG A . n A 1 402 HIS 402 402 402 HIS HIS A . n A 1 403 THR 403 403 403 THR THR A . n A 1 404 PRO 404 404 404 PRO PRO A . n A 1 405 VAL 405 405 405 VAL VAL A . n A 1 406 ASN 406 406 406 ASN ASN A . n A 1 407 SER 407 407 407 SER SER A . n A 1 408 TRP 408 408 408 TRP TRP A . n A 1 409 LEU 409 409 409 LEU LEU A . n A 1 410 GLY 410 410 410 GLY GLY A . n A 1 411 ASN 411 411 411 ASN ASN A . n A 1 412 ILE 412 412 412 ILE ILE A . n A 1 413 ILE 413 413 413 ILE ILE A . n A 1 414 MET 414 414 414 MET MET A . n A 1 415 TYR 415 415 415 TYR TYR A . n A 1 416 ALA 416 416 416 ALA ALA A . n A 1 417 PRO 417 417 417 PRO PRO A . n A 1 418 THR 418 418 418 THR THR A . n A 1 419 LEU 419 419 419 LEU LEU A . n A 1 420 TRP 420 420 420 TRP TRP A . n A 1 421 ALA 421 421 421 ALA ALA A . n A 1 422 ARG 422 422 422 ARG ARG A . n A 1 423 MET 423 423 423 MET MET A . n A 1 424 ILE 424 424 424 ILE ILE A . n A 1 425 LEU 425 425 425 LEU LEU A . n A 1 426 MET 426 426 426 MET MET A . n A 1 427 THR 427 427 427 THR THR A . n A 1 428 HIS 428 428 428 HIS HIS A . n A 1 429 PHE 429 429 429 PHE PHE A . n A 1 430 PHE 430 430 430 PHE PHE A . n A 1 431 SER 431 431 431 SER SER A . n A 1 432 ILE 432 432 432 ILE ILE A . n A 1 433 LEU 433 433 433 LEU LEU A . n A 1 434 LEU 434 434 434 LEU LEU A . n A 1 435 ALA 435 435 435 ALA ALA A . n A 1 436 GLN 436 436 436 GLN GLN A . n A 1 437 GLU 437 437 437 GLU GLU A . n A 1 438 GLN 438 438 438 GLN GLN A . n A 1 439 LEU 439 439 439 LEU LEU A . n A 1 440 GLU 440 440 440 GLU GLU A . n A 1 441 LYS 441 441 441 LYS LYS A . n A 1 442 ALA 442 442 442 ALA ALA A . n A 1 443 LEU 443 443 443 LEU LEU A . n A 1 444 ASP 444 444 444 ASP ASP A . n A 1 445 CYS 445 445 445 CYS CYS A . n A 1 446 GLN 446 446 446 GLN GLN A . n A 1 447 ILE 447 447 447 ILE ILE A . n A 1 448 TYR 448 448 448 TYR TYR A . n A 1 449 GLY 449 449 449 GLY GLY A . n A 1 450 ALA 450 450 450 ALA ALA A . n A 1 451 CYS 451 451 451 CYS CYS A . n A 1 452 TYR 452 452 452 TYR TYR A . n A 1 453 SER 453 453 453 SER SER A . n A 1 454 ILE 454 454 454 ILE ILE A . n A 1 455 GLU 455 455 455 GLU GLU A . n A 1 456 PRO 456 456 456 PRO PRO A . n A 1 457 LEU 457 457 457 LEU LEU A . n A 1 458 ASP 458 458 458 ASP ASP A . n A 1 459 LEU 459 459 459 LEU LEU A . n A 1 460 PRO 460 460 460 PRO PRO A . n A 1 461 GLN 461 461 461 GLN GLN A . n A 1 462 ILE 462 462 462 ILE ILE A . n A 1 463 ILE 463 463 463 ILE ILE A . n A 1 464 GLU 464 464 464 GLU GLU A . n A 1 465 ARG 465 465 465 ARG ARG A . n A 1 466 LEU 466 466 466 LEU LEU A . n A 1 467 HIS 467 467 467 HIS HIS A . n A 1 468 GLY 468 468 468 GLY GLY A . n A 1 469 LEU 469 469 469 LEU LEU A . n A 1 470 SER 470 470 470 SER SER A . n A 1 471 ALA 471 471 471 ALA ALA A . n A 1 472 PHE 472 472 472 PHE PHE A . n A 1 473 SER 473 473 473 SER SER A . n A 1 474 LEU 474 474 474 LEU LEU A . n A 1 475 HIS 475 475 475 HIS HIS A . n A 1 476 SER 476 476 476 SER SER A . n A 1 477 TYR 477 477 477 TYR TYR A . n A 1 478 SER 478 478 478 SER SER A . n A 1 479 PRO 479 479 479 PRO PRO A . n A 1 480 GLY 480 480 480 GLY GLY A . n A 1 481 GLU 481 481 481 GLU GLU A . n A 1 482 ILE 482 482 482 ILE ILE A . n A 1 483 ASN 483 483 483 ASN ASN A . n A 1 484 ARG 484 484 484 ARG ARG A . n A 1 485 VAL 485 485 485 VAL VAL A . n A 1 486 ALA 486 486 486 ALA ALA A . n A 1 487 SER 487 487 487 SER SER A . n A 1 488 CYS 488 488 488 CYS CYS A . n A 1 489 LEU 489 489 489 LEU LEU A . n A 1 490 ARG 490 490 490 ARG ARG A . n A 1 491 LYS 491 491 491 LYS LYS A . n A 1 492 LEU 492 492 492 LEU LEU A . n A 1 493 GLY 493 493 493 GLY GLY A . n A 1 494 VAL 494 494 494 VAL VAL A . n A 1 495 PRO 495 495 495 PRO PRO A . n A 1 496 PRO 496 496 496 PRO PRO A . n A 1 497 LEU 497 497 497 LEU LEU A . n A 1 498 ARG 498 498 498 ARG ARG A . n A 1 499 VAL 499 499 499 VAL VAL A . n A 1 500 TRP 500 500 500 TRP TRP A . n A 1 501 ARG 501 501 501 ARG ARG A . n A 1 502 HIS 502 502 502 HIS HIS A . n A 1 503 ARG 503 503 503 ARG ARG A . n A 1 504 ALA 504 504 504 ALA ALA A . n A 1 505 ARG 505 505 505 ARG ARG A . n A 1 506 SER 506 506 506 SER SER A . n A 1 507 VAL 507 507 507 VAL VAL A . n A 1 508 ARG 508 508 508 ARG ARG A . n A 1 509 ALA 509 509 509 ALA ALA A . n A 1 510 ARG 510 510 510 ARG ARG A . n A 1 511 LEU 511 511 511 LEU LEU A . n A 1 512 LEU 512 512 512 LEU LEU A . n A 1 513 SER 513 513 513 SER SER A . n A 1 514 GLN 514 514 514 GLN GLN A . n A 1 515 GLY 515 515 515 GLY GLY A . n A 1 516 GLY 516 516 516 GLY GLY A . n A 1 517 ARG 517 517 517 ARG ARG A . n A 1 518 ALA 518 518 518 ALA ALA A . n A 1 519 ALA 519 519 519 ALA ALA A . n A 1 520 THR 520 520 520 THR THR A . n A 1 521 CYS 521 521 521 CYS CYS A . n A 1 522 GLY 522 522 522 GLY GLY A . n A 1 523 LYS 523 523 523 LYS LYS A . n A 1 524 TYR 524 524 524 TYR TYR A . n A 1 525 LEU 525 525 525 LEU LEU A . n A 1 526 PHE 526 526 526 PHE PHE A . n A 1 527 ASN 527 527 527 ASN ASN A . n A 1 528 TRP 528 528 528 TRP TRP A . n A 1 529 ALA 529 529 529 ALA ALA A . n A 1 530 VAL 530 530 530 VAL VAL A . n A 1 531 LYS 531 531 531 LYS LYS A . n A 1 532 THR 532 532 532 THR THR A . n A 1 533 LYS 533 533 533 LYS LYS A . n A 1 534 LEU 534 534 534 LEU LEU A . n A 1 535 LYS 535 535 535 LYS LYS A . n A 1 536 LEU 536 536 536 LEU LEU A . n A 1 537 THR 537 537 537 THR THR A . n A 1 538 PRO 538 538 538 PRO PRO A . n A 1 539 ILE 539 539 539 ILE ILE A . n A 1 540 PRO 540 540 ? ? ? A . n A 1 541 ALA 541 541 ? ? ? A . n A 1 542 ALA 542 542 ? ? ? A . n A 1 543 SER 543 543 ? ? ? A . n A 1 544 ARG 544 544 ? ? ? A . n A 1 545 LEU 545 545 ? ? ? A . n A 1 546 ASP 546 546 ? ? ? A . n A 1 547 LEU 547 547 ? ? ? A . n A 1 548 SER 548 548 ? ? ? A . n A 1 549 GLY 549 549 ? ? ? A . n A 1 550 TRP 550 550 ? ? ? A . n A 1 551 PHE 551 551 551 PHE PHE A . n A 1 552 VAL 552 552 552 VAL VAL A . n A 1 553 ALA 553 553 553 ALA ALA A . n A 1 554 GLY 554 554 554 GLY GLY A . n A 1 555 TYR 555 555 555 TYR TYR A . n A 1 556 SER 556 556 556 SER SER A . n A 1 557 GLY 557 557 557 GLY GLY A . n A 1 558 GLY 558 558 558 GLY GLY A . n A 1 559 ASP 559 559 559 ASP ASP A . n A 1 560 ILE 560 560 560 ILE ILE A . n A 1 561 TYR 561 561 561 TYR TYR A . n A 1 562 HIS 562 562 562 HIS HIS A . n A 1 563 SER 563 563 ? ? ? A . n A 1 564 LEU 564 564 ? ? ? A . n A 1 565 SER 565 565 ? ? ? A . n A 1 566 ARG 566 566 ? ? ? A . n A 1 567 ALA 567 567 ? ? ? A . n A 1 568 ARG 568 568 ? ? ? A . n A 1 569 PRO 569 569 ? ? ? A . n A 1 570 ARG 570 570 ? ? ? A . n B 1 1 HIS 1 1 1 HIS HIS B . n B 1 2 MET 2 2 2 MET MET B . n B 1 3 SER 3 3 3 SER SER B . n B 1 4 TYR 4 4 4 TYR TYR B . n B 1 5 THR 5 5 5 THR THR B . n B 1 6 TRP 6 6 6 TRP TRP B . n B 1 7 THR 7 7 7 THR THR B . n B 1 8 GLY 8 8 8 GLY GLY B . n B 1 9 ALA 9 9 9 ALA ALA B . n B 1 10 LEU 10 10 10 LEU LEU B . n B 1 11 ILE 11 11 11 ILE ILE B . n B 1 12 THR 12 12 12 THR THR B . n B 1 13 PRO 13 13 13 PRO PRO B . n B 1 14 CYS 14 14 14 CYS CYS B . n B 1 15 ALA 15 15 15 ALA ALA B . n B 1 16 ALA 16 16 16 ALA ALA B . n B 1 17 GLU 17 17 17 GLU GLU B . n B 1 18 GLU 18 18 18 GLU GLU B . n B 1 19 SER 19 19 19 SER SER B . n B 1 20 LYS 20 20 20 LYS LYS B . n B 1 21 LEU 21 21 21 LEU LEU B . n B 1 22 PRO 22 22 22 PRO PRO B . n B 1 23 ILE 23 23 23 ILE ILE B . n B 1 24 ASN 24 24 24 ASN ASN B . n B 1 25 ALA 25 25 25 ALA ALA B . n B 1 26 LEU 26 26 26 LEU LEU B . n B 1 27 SER 27 27 27 SER SER B . n B 1 28 ASN 28 28 28 ASN ASN B . n B 1 29 SER 29 29 29 SER SER B . n B 1 30 LEU 30 30 30 LEU LEU B . n B 1 31 LEU 31 31 31 LEU LEU B . n B 1 32 ARG 32 32 32 ARG ARG B . n B 1 33 HIS 33 33 33 HIS HIS B . n B 1 34 HIS 34 34 34 HIS HIS B . n B 1 35 ASN 35 35 35 ASN ASN B . n B 1 36 MET 36 36 36 MET MET B . n B 1 37 VAL 37 37 37 VAL VAL B . n B 1 38 TYR 38 38 38 TYR TYR B . n B 1 39 ALA 39 39 39 ALA ALA B . n B 1 40 THR 40 40 40 THR THR B . n B 1 41 THR 41 41 41 THR THR B . n B 1 42 SER 42 42 42 SER SER B . n B 1 43 ARG 43 43 43 ARG ARG B . n B 1 44 SER 44 44 44 SER SER B . n B 1 45 ALA 45 45 45 ALA ALA B . n B 1 46 GLY 46 46 46 GLY GLY B . n B 1 47 LEU 47 47 47 LEU LEU B . n B 1 48 ARG 48 48 48 ARG ARG B . n B 1 49 GLN 49 49 49 GLN GLN B . n B 1 50 LYS 50 50 50 LYS LYS B . n B 1 51 LYS 51 51 51 LYS LYS B . n B 1 52 VAL 52 52 52 VAL VAL B . n B 1 53 THR 53 53 53 THR THR B . n B 1 54 PHE 54 54 54 PHE PHE B . n B 1 55 ASP 55 55 55 ASP ASP B . n B 1 56 ARG 56 56 56 ARG ARG B . n B 1 57 LEU 57 57 57 LEU LEU B . n B 1 58 GLN 58 58 58 GLN GLN B . n B 1 59 VAL 59 59 59 VAL VAL B . n B 1 60 LEU 60 60 60 LEU LEU B . n B 1 61 ASP 61 61 61 ASP ASP B . n B 1 62 ASP 62 62 62 ASP ASP B . n B 1 63 HIS 63 63 63 HIS HIS B . n B 1 64 TYR 64 64 64 TYR TYR B . n B 1 65 ARG 65 65 65 ARG ARG B . n B 1 66 ASP 66 66 66 ASP ASP B . n B 1 67 VAL 67 67 67 VAL VAL B . n B 1 68 LEU 68 68 68 LEU LEU B . n B 1 69 LYS 69 69 69 LYS LYS B . n B 1 70 GLU 70 70 70 GLU GLU B . n B 1 71 MET 71 71 71 MET MET B . n B 1 72 LYS 72 72 72 LYS LYS B . n B 1 73 ALA 73 73 73 ALA ALA B . n B 1 74 LYS 74 74 74 LYS LYS B . n B 1 75 ALA 75 75 75 ALA ALA B . n B 1 76 SER 76 76 76 SER SER B . n B 1 77 THR 77 77 77 THR THR B . n B 1 78 VAL 78 78 78 VAL VAL B . n B 1 79 LYS 79 79 79 LYS LYS B . n B 1 80 ALA 80 80 80 ALA ALA B . n B 1 81 LYS 81 81 81 LYS LYS B . n B 1 82 LEU 82 82 82 LEU LEU B . n B 1 83 LEU 83 83 83 LEU LEU B . n B 1 84 SER 84 84 84 SER SER B . n B 1 85 VAL 85 85 85 VAL VAL B . n B 1 86 GLU 86 86 86 GLU GLU B . n B 1 87 GLU 87 87 87 GLU GLU B . n B 1 88 ALA 88 88 88 ALA ALA B . n B 1 89 CYS 89 89 89 CYS CYS B . n B 1 90 LYS 90 90 90 LYS LYS B . n B 1 91 LEU 91 91 91 LEU LEU B . n B 1 92 THR 92 92 92 THR THR B . n B 1 93 PRO 93 93 93 PRO PRO B . n B 1 94 PRO 94 94 94 PRO PRO B . n B 1 95 HIS 95 95 95 HIS HIS B . n B 1 96 SER 96 96 96 SER SER B . n B 1 97 ALA 97 97 97 ALA ALA B . n B 1 98 LYS 98 98 98 LYS LYS B . n B 1 99 SER 99 99 99 SER SER B . n B 1 100 LYS 100 100 100 LYS LYS B . n B 1 101 PHE 101 101 101 PHE PHE B . n B 1 102 GLY 102 102 102 GLY GLY B . n B 1 103 TYR 103 103 103 TYR TYR B . n B 1 104 GLY 104 104 104 GLY GLY B . n B 1 105 ALA 105 105 105 ALA ALA B . n B 1 106 LYS 106 106 106 LYS LYS B . n B 1 107 ASP 107 107 107 ASP ASP B . n B 1 108 VAL 108 108 108 VAL VAL B . n B 1 109 ARG 109 109 109 ARG ARG B . n B 1 110 ASN 110 110 110 ASN ASN B . n B 1 111 LEU 111 111 111 LEU LEU B . n B 1 112 SER 112 112 112 SER SER B . n B 1 113 SER 113 113 113 SER SER B . n B 1 114 LYS 114 114 114 LYS LYS B . n B 1 115 ALA 115 115 115 ALA ALA B . n B 1 116 VAL 116 116 116 VAL VAL B . n B 1 117 ASN 117 117 117 ASN ASN B . n B 1 118 HIS 118 118 118 HIS HIS B . n B 1 119 ILE 119 119 119 ILE ILE B . n B 1 120 HIS 120 120 120 HIS HIS B . n B 1 121 SER 121 121 121 SER SER B . n B 1 122 VAL 122 122 122 VAL VAL B . n B 1 123 TRP 123 123 123 TRP TRP B . n B 1 124 LYS 124 124 124 LYS LYS B . n B 1 125 ASP 125 125 125 ASP ASP B . n B 1 126 LEU 126 126 126 LEU LEU B . n B 1 127 LEU 127 127 127 LEU LEU B . n B 1 128 GLU 128 128 128 GLU GLU B . n B 1 129 ASP 129 129 129 ASP ASP B . n B 1 130 THR 130 130 130 THR THR B . n B 1 131 VAL 131 131 131 VAL VAL B . n B 1 132 THR 132 132 132 THR THR B . n B 1 133 PRO 133 133 133 PRO PRO B . n B 1 134 ILE 134 134 134 ILE ILE B . n B 1 135 ASP 135 135 135 ASP ASP B . n B 1 136 THR 136 136 136 THR THR B . n B 1 137 THR 137 137 137 THR THR B . n B 1 138 ILE 138 138 138 ILE ILE B . n B 1 139 MET 139 139 139 MET MET B . n B 1 140 ALA 140 140 140 ALA ALA B . n B 1 141 LYS 141 141 141 LYS LYS B . n B 1 142 ASN 142 142 142 ASN ASN B . n B 1 143 GLU 143 143 143 GLU GLU B . n B 1 144 VAL 144 144 144 VAL VAL B . n B 1 145 PHE 145 145 145 PHE PHE B . n B 1 146 CYS 146 146 146 CYS CYS B . n B 1 147 VAL 147 147 147 VAL VAL B . n B 1 148 GLN 148 148 148 GLN GLN B . n B 1 149 PRO 149 149 ? ? ? B . n B 1 150 GLU 150 150 ? ? ? B . n B 1 151 LYS 151 151 ? ? ? B . n B 1 152 GLY 152 152 ? ? ? B . n B 1 153 GLY 153 153 ? ? ? B . n B 1 154 ARG 154 154 154 ARG ARG B . n B 1 155 LYS 155 155 155 LYS LYS B . n B 1 156 PRO 156 156 156 PRO PRO B . n B 1 157 ALA 157 157 157 ALA ALA B . n B 1 158 ARG 158 158 158 ARG ARG B . n B 1 159 LEU 159 159 159 LEU LEU B . n B 1 160 ILE 160 160 160 ILE ILE B . n B 1 161 VAL 161 161 161 VAL VAL B . n B 1 162 PHE 162 162 162 PHE PHE B . n B 1 163 PRO 163 163 163 PRO PRO B . n B 1 164 ASP 164 164 164 ASP ASP B . n B 1 165 LEU 165 165 165 LEU LEU B . n B 1 166 GLY 166 166 166 GLY GLY B . n B 1 167 VAL 167 167 167 VAL VAL B . n B 1 168 ARG 168 168 168 ARG ARG B . n B 1 169 VAL 169 169 169 VAL VAL B . n B 1 170 CYS 170 170 170 CYS CYS B . n B 1 171 GLU 171 171 171 GLU GLU B . n B 1 172 LYS 172 172 172 LYS LYS B . n B 1 173 MET 173 173 173 MET MET B . n B 1 174 ALA 174 174 174 ALA ALA B . n B 1 175 LEU 175 175 175 LEU LEU B . n B 1 176 TYR 176 176 176 TYR TYR B . n B 1 177 ASP 177 177 177 ASP ASP B . n B 1 178 VAL 178 178 178 VAL VAL B . n B 1 179 VAL 179 179 179 VAL VAL B . n B 1 180 SER 180 180 180 SER SER B . n B 1 181 THR 181 181 181 THR THR B . n B 1 182 LEU 182 182 182 LEU LEU B . n B 1 183 PRO 183 183 183 PRO PRO B . n B 1 184 GLN 184 184 184 GLN GLN B . n B 1 185 VAL 185 185 185 VAL VAL B . n B 1 186 VAL 186 186 186 VAL VAL B . n B 1 187 MET 187 187 187 MET MET B . n B 1 188 GLY 188 188 188 GLY GLY B . n B 1 189 SER 189 189 189 SER SER B . n B 1 190 SER 190 190 190 SER SER B . n B 1 191 TYR 191 191 191 TYR TYR B . n B 1 192 GLY 192 192 192 GLY GLY B . n B 1 193 PHE 193 193 193 PHE PHE B . n B 1 194 GLN 194 194 194 GLN GLN B . n B 1 195 TYR 195 195 195 TYR TYR B . n B 1 196 SER 196 196 196 SER SER B . n B 1 197 PRO 197 197 197 PRO PRO B . n B 1 198 GLY 198 198 198 GLY GLY B . n B 1 199 GLN 199 199 199 GLN GLN B . n B 1 200 ARG 200 200 200 ARG ARG B . n B 1 201 VAL 201 201 201 VAL VAL B . n B 1 202 GLU 202 202 202 GLU GLU B . n B 1 203 PHE 203 203 203 PHE PHE B . n B 1 204 LEU 204 204 204 LEU LEU B . n B 1 205 VAL 205 205 205 VAL VAL B . n B 1 206 ASN 206 206 206 ASN ASN B . n B 1 207 THR 207 207 207 THR THR B . n B 1 208 TRP 208 208 208 TRP TRP B . n B 1 209 LYS 209 209 209 LYS LYS B . n B 1 210 SER 210 210 210 SER SER B . n B 1 211 LYS 211 211 211 LYS LYS B . n B 1 212 LYS 212 212 212 LYS LYS B . n B 1 213 ASN 213 213 213 ASN ASN B . n B 1 214 PRO 214 214 214 PRO PRO B . n B 1 215 MET 215 215 215 MET MET B . n B 1 216 GLY 216 216 216 GLY GLY B . n B 1 217 PHE 217 217 217 PHE PHE B . n B 1 218 SER 218 218 218 SER SER B . n B 1 219 TYR 219 219 219 TYR TYR B . n B 1 220 ASP 220 220 220 ASP ASP B . n B 1 221 THR 221 221 221 THR THR B . n B 1 222 ARG 222 222 222 ARG ARG B . n B 1 223 CYS 223 223 223 CYS CYS B . n B 1 224 PHE 224 224 224 PHE PHE B . n B 1 225 ASP 225 225 225 ASP ASP B . n B 1 226 SER 226 226 226 SER SER B . n B 1 227 THR 227 227 227 THR THR B . n B 1 228 VAL 228 228 228 VAL VAL B . n B 1 229 THR 229 229 229 THR THR B . n B 1 230 GLU 230 230 230 GLU GLU B . n B 1 231 ASN 231 231 231 ASN ASN B . n B 1 232 ASP 232 232 232 ASP ASP B . n B 1 233 ILE 233 233 233 ILE ILE B . n B 1 234 ARG 234 234 234 ARG ARG B . n B 1 235 VAL 235 235 235 VAL VAL B . n B 1 236 GLU 236 236 236 GLU GLU B . n B 1 237 GLU 237 237 237 GLU GLU B . n B 1 238 SER 238 238 238 SER SER B . n B 1 239 ILE 239 239 239 ILE ILE B . n B 1 240 TYR 240 240 240 TYR TYR B . n B 1 241 GLN 241 241 241 GLN GLN B . n B 1 242 CYS 242 242 242 CYS CYS B . n B 1 243 CYS 243 243 243 CYS CYS B . n B 1 244 ASP 244 244 244 ASP ASP B . n B 1 245 LEU 245 245 245 LEU LEU B . n B 1 246 ALA 246 246 246 ALA ALA B . n B 1 247 PRO 247 247 247 PRO PRO B . n B 1 248 GLU 248 248 248 GLU GLU B . n B 1 249 ALA 249 249 249 ALA ALA B . n B 1 250 ARG 250 250 250 ARG ARG B . n B 1 251 GLN 251 251 251 GLN GLN B . n B 1 252 ALA 252 252 252 ALA ALA B . n B 1 253 ILE 253 253 253 ILE ILE B . n B 1 254 LYS 254 254 254 LYS LYS B . n B 1 255 SER 255 255 255 SER SER B . n B 1 256 LEU 256 256 256 LEU LEU B . n B 1 257 THR 257 257 257 THR THR B . n B 1 258 GLU 258 258 258 GLU GLU B . n B 1 259 ARG 259 259 259 ARG ARG B . n B 1 260 LEU 260 260 260 LEU LEU B . n B 1 261 TYR 261 261 261 TYR TYR B . n B 1 262 ILE 262 262 262 ILE ILE B . n B 1 263 GLY 263 263 263 GLY GLY B . n B 1 264 GLY 264 264 264 GLY GLY B . n B 1 265 PRO 265 265 265 PRO PRO B . n B 1 266 LEU 266 266 266 LEU LEU B . n B 1 267 THR 267 267 267 THR THR B . n B 1 268 ASN 268 268 268 ASN ASN B . n B 1 269 SER 269 269 269 SER SER B . n B 1 270 LYS 270 270 270 LYS LYS B . n B 1 271 GLY 271 271 271 GLY GLY B . n B 1 272 GLN 272 272 272 GLN GLN B . n B 1 273 ASN 273 273 273 ASN ASN B . n B 1 274 CYS 274 274 274 CYS CYS B . n B 1 275 GLY 275 275 275 GLY GLY B . n B 1 276 TYR 276 276 276 TYR TYR B . n B 1 277 ARG 277 277 277 ARG ARG B . n B 1 278 ARG 278 278 278 ARG ARG B . n B 1 279 CYS 279 279 279 CYS CYS B . n B 1 280 ARG 280 280 280 ARG ARG B . n B 1 281 ALA 281 281 281 ALA ALA B . n B 1 282 SER 282 282 282 SER SER B . n B 1 283 GLY 283 283 283 GLY GLY B . n B 1 284 VAL 284 284 284 VAL VAL B . n B 1 285 LEU 285 285 285 LEU LEU B . n B 1 286 THR 286 286 286 THR THR B . n B 1 287 THR 287 287 287 THR THR B . n B 1 288 SER 288 288 288 SER SER B . n B 1 289 CYS 289 289 289 CYS CYS B . n B 1 290 GLY 290 290 290 GLY GLY B . n B 1 291 ASN 291 291 291 ASN ASN B . n B 1 292 THR 292 292 292 THR THR B . n B 1 293 LEU 293 293 293 LEU LEU B . n B 1 294 THR 294 294 294 THR THR B . n B 1 295 CYS 295 295 295 CYS CYS B . n B 1 296 TYR 296 296 296 TYR TYR B . n B 1 297 LEU 297 297 297 LEU LEU B . n B 1 298 LYS 298 298 298 LYS LYS B . n B 1 299 ALA 299 299 299 ALA ALA B . n B 1 300 SER 300 300 300 SER SER B . n B 1 301 ALA 301 301 301 ALA ALA B . n B 1 302 ALA 302 302 302 ALA ALA B . n B 1 303 CYS 303 303 303 CYS CYS B . n B 1 304 ARG 304 304 304 ARG ARG B . n B 1 305 ALA 305 305 305 ALA ALA B . n B 1 306 ALA 306 306 306 ALA ALA B . n B 1 307 LYS 307 307 307 LYS LYS B . n B 1 308 LEU 308 308 308 LEU LEU B . n B 1 309 GLN 309 309 309 GLN GLN B . n B 1 310 ASP 310 310 310 ASP ASP B . n B 1 311 CYS 311 311 311 CYS CYS B . n B 1 312 THR 312 312 312 THR THR B . n B 1 313 MET 313 313 313 MET MET B . n B 1 314 LEU 314 314 314 LEU LEU B . n B 1 315 VAL 315 315 315 VAL VAL B . n B 1 316 ASN 316 316 316 ASN ASN B . n B 1 317 GLY 317 317 317 GLY GLY B . n B 1 318 ASP 318 318 318 ASP ASP B . n B 1 319 ASP 319 319 319 ASP ASP B . n B 1 320 LEU 320 320 320 LEU LEU B . n B 1 321 VAL 321 321 321 VAL VAL B . n B 1 322 VAL 322 322 322 VAL VAL B . n B 1 323 ILE 323 323 323 ILE ILE B . n B 1 324 CYS 324 324 324 CYS CYS B . n B 1 325 GLU 325 325 325 GLU GLU B . n B 1 326 SER 326 326 326 SER SER B . n B 1 327 ALA 327 327 327 ALA ALA B . n B 1 328 GLY 328 328 328 GLY GLY B . n B 1 329 THR 329 329 329 THR THR B . n B 1 330 GLN 330 330 330 GLN GLN B . n B 1 331 GLU 331 331 331 GLU GLU B . n B 1 332 ASP 332 332 332 ASP ASP B . n B 1 333 ALA 333 333 333 ALA ALA B . n B 1 334 ALA 334 334 334 ALA ALA B . n B 1 335 SER 335 335 335 SER SER B . n B 1 336 LEU 336 336 336 LEU LEU B . n B 1 337 ARG 337 337 337 ARG ARG B . n B 1 338 VAL 338 338 338 VAL VAL B . n B 1 339 PHE 339 339 339 PHE PHE B . n B 1 340 THR 340 340 340 THR THR B . n B 1 341 GLU 341 341 341 GLU GLU B . n B 1 342 ALA 342 342 342 ALA ALA B . n B 1 343 MET 343 343 343 MET MET B . n B 1 344 THR 344 344 344 THR THR B . n B 1 345 ARG 345 345 345 ARG ARG B . n B 1 346 TYR 346 346 346 TYR TYR B . n B 1 347 SER 347 347 347 SER SER B . n B 1 348 ALA 348 348 348 ALA ALA B . n B 1 349 PRO 349 349 349 PRO PRO B . n B 1 350 PRO 350 350 350 PRO PRO B . n B 1 351 GLY 351 351 351 GLY GLY B . n B 1 352 ASP 352 352 352 ASP ASP B . n B 1 353 PRO 353 353 353 PRO PRO B . n B 1 354 PRO 354 354 354 PRO PRO B . n B 1 355 GLN 355 355 355 GLN GLN B . n B 1 356 PRO 356 356 356 PRO PRO B . n B 1 357 GLU 357 357 357 GLU GLU B . n B 1 358 TYR 358 358 358 TYR TYR B . n B 1 359 ASP 359 359 359 ASP ASP B . n B 1 360 LEU 360 360 360 LEU LEU B . n B 1 361 GLU 361 361 361 GLU GLU B . n B 1 362 LEU 362 362 362 LEU LEU B . n B 1 363 ILE 363 363 363 ILE ILE B . n B 1 364 THR 364 364 364 THR THR B . n B 1 365 SER 365 365 365 SER SER B . n B 1 366 CYS 366 366 366 CYS CYS B . n B 1 367 SER 367 367 367 SER SER B . n B 1 368 SER 368 368 368 SER SER B . n B 1 369 ASN 369 369 369 ASN ASN B . n B 1 370 VAL 370 370 370 VAL VAL B . n B 1 371 SER 371 371 371 SER SER B . n B 1 372 VAL 372 372 372 VAL VAL B . n B 1 373 ALA 373 373 373 ALA ALA B . n B 1 374 HIS 374 374 374 HIS HIS B . n B 1 375 ASP 375 375 375 ASP ASP B . n B 1 376 ALA 376 376 376 ALA ALA B . n B 1 377 SER 377 377 377 SER SER B . n B 1 378 GLY 378 378 378 GLY GLY B . n B 1 379 LYS 379 379 379 LYS LYS B . n B 1 380 ARG 380 380 380 ARG ARG B . n B 1 381 VAL 381 381 381 VAL VAL B . n B 1 382 TYR 382 382 382 TYR TYR B . n B 1 383 TYR 383 383 383 TYR TYR B . n B 1 384 LEU 384 384 384 LEU LEU B . n B 1 385 THR 385 385 385 THR THR B . n B 1 386 ARG 386 386 386 ARG ARG B . n B 1 387 ASP 387 387 387 ASP ASP B . n B 1 388 PRO 388 388 388 PRO PRO B . n B 1 389 THR 389 389 389 THR THR B . n B 1 390 THR 390 390 390 THR THR B . n B 1 391 PRO 391 391 391 PRO PRO B . n B 1 392 LEU 392 392 392 LEU LEU B . n B 1 393 ALA 393 393 393 ALA ALA B . n B 1 394 ARG 394 394 394 ARG ARG B . n B 1 395 ALA 395 395 395 ALA ALA B . n B 1 396 ALA 396 396 396 ALA ALA B . n B 1 397 TRP 397 397 397 TRP TRP B . n B 1 398 GLU 398 398 398 GLU GLU B . n B 1 399 THR 399 399 399 THR THR B . n B 1 400 ALA 400 400 400 ALA ALA B . n B 1 401 ARG 401 401 401 ARG ARG B . n B 1 402 HIS 402 402 402 HIS HIS B . n B 1 403 THR 403 403 403 THR THR B . n B 1 404 PRO 404 404 404 PRO PRO B . n B 1 405 VAL 405 405 405 VAL VAL B . n B 1 406 ASN 406 406 406 ASN ASN B . n B 1 407 SER 407 407 407 SER SER B . n B 1 408 TRP 408 408 408 TRP TRP B . n B 1 409 LEU 409 409 409 LEU LEU B . n B 1 410 GLY 410 410 410 GLY GLY B . n B 1 411 ASN 411 411 411 ASN ASN B . n B 1 412 ILE 412 412 412 ILE ILE B . n B 1 413 ILE 413 413 413 ILE ILE B . n B 1 414 MET 414 414 414 MET MET B . n B 1 415 TYR 415 415 415 TYR TYR B . n B 1 416 ALA 416 416 416 ALA ALA B . n B 1 417 PRO 417 417 417 PRO PRO B . n B 1 418 THR 418 418 418 THR THR B . n B 1 419 LEU 419 419 419 LEU LEU B . n B 1 420 TRP 420 420 420 TRP TRP B . n B 1 421 ALA 421 421 421 ALA ALA B . n B 1 422 ARG 422 422 422 ARG ARG B . n B 1 423 MET 423 423 423 MET MET B . n B 1 424 ILE 424 424 424 ILE ILE B . n B 1 425 LEU 425 425 425 LEU LEU B . n B 1 426 MET 426 426 426 MET MET B . n B 1 427 THR 427 427 427 THR THR B . n B 1 428 HIS 428 428 428 HIS HIS B . n B 1 429 PHE 429 429 429 PHE PHE B . n B 1 430 PHE 430 430 430 PHE PHE B . n B 1 431 SER 431 431 431 SER SER B . n B 1 432 ILE 432 432 432 ILE ILE B . n B 1 433 LEU 433 433 433 LEU LEU B . n B 1 434 LEU 434 434 434 LEU LEU B . n B 1 435 ALA 435 435 435 ALA ALA B . n B 1 436 GLN 436 436 436 GLN GLN B . n B 1 437 GLU 437 437 437 GLU GLU B . n B 1 438 GLN 438 438 438 GLN GLN B . n B 1 439 LEU 439 439 439 LEU LEU B . n B 1 440 GLU 440 440 440 GLU GLU B . n B 1 441 LYS 441 441 441 LYS LYS B . n B 1 442 ALA 442 442 442 ALA ALA B . n B 1 443 LEU 443 443 443 LEU LEU B . n B 1 444 ASP 444 444 444 ASP ASP B . n B 1 445 CYS 445 445 445 CYS CYS B . n B 1 446 GLN 446 446 446 GLN GLN B . n B 1 447 ILE 447 447 447 ILE ILE B . n B 1 448 TYR 448 448 448 TYR TYR B . n B 1 449 GLY 449 449 449 GLY GLY B . n B 1 450 ALA 450 450 450 ALA ALA B . n B 1 451 CYS 451 451 451 CYS CYS B . n B 1 452 TYR 452 452 452 TYR TYR B . n B 1 453 SER 453 453 453 SER SER B . n B 1 454 ILE 454 454 454 ILE ILE B . n B 1 455 GLU 455 455 455 GLU GLU B . n B 1 456 PRO 456 456 456 PRO PRO B . n B 1 457 LEU 457 457 457 LEU LEU B . n B 1 458 ASP 458 458 458 ASP ASP B . n B 1 459 LEU 459 459 459 LEU LEU B . n B 1 460 PRO 460 460 460 PRO PRO B . n B 1 461 GLN 461 461 461 GLN GLN B . n B 1 462 ILE 462 462 462 ILE ILE B . n B 1 463 ILE 463 463 463 ILE ILE B . n B 1 464 GLU 464 464 464 GLU GLU B . n B 1 465 ARG 465 465 465 ARG ARG B . n B 1 466 LEU 466 466 466 LEU LEU B . n B 1 467 HIS 467 467 467 HIS HIS B . n B 1 468 GLY 468 468 468 GLY GLY B . n B 1 469 LEU 469 469 469 LEU LEU B . n B 1 470 SER 470 470 470 SER SER B . n B 1 471 ALA 471 471 471 ALA ALA B . n B 1 472 PHE 472 472 472 PHE PHE B . n B 1 473 SER 473 473 473 SER SER B . n B 1 474 LEU 474 474 474 LEU LEU B . n B 1 475 HIS 475 475 475 HIS HIS B . n B 1 476 SER 476 476 476 SER SER B . n B 1 477 TYR 477 477 477 TYR TYR B . n B 1 478 SER 478 478 478 SER SER B . n B 1 479 PRO 479 479 479 PRO PRO B . n B 1 480 GLY 480 480 480 GLY GLY B . n B 1 481 GLU 481 481 481 GLU GLU B . n B 1 482 ILE 482 482 482 ILE ILE B . n B 1 483 ASN 483 483 483 ASN ASN B . n B 1 484 ARG 484 484 484 ARG ARG B . n B 1 485 VAL 485 485 485 VAL VAL B . n B 1 486 ALA 486 486 486 ALA ALA B . n B 1 487 SER 487 487 487 SER SER B . n B 1 488 CYS 488 488 488 CYS CYS B . n B 1 489 LEU 489 489 489 LEU LEU B . n B 1 490 ARG 490 490 490 ARG ARG B . n B 1 491 LYS 491 491 491 LYS LYS B . n B 1 492 LEU 492 492 492 LEU LEU B . n B 1 493 GLY 493 493 493 GLY GLY B . n B 1 494 VAL 494 494 494 VAL VAL B . n B 1 495 PRO 495 495 495 PRO PRO B . n B 1 496 PRO 496 496 496 PRO PRO B . n B 1 497 LEU 497 497 497 LEU LEU B . n B 1 498 ARG 498 498 498 ARG ARG B . n B 1 499 VAL 499 499 499 VAL VAL B . n B 1 500 TRP 500 500 500 TRP TRP B . n B 1 501 ARG 501 501 501 ARG ARG B . n B 1 502 HIS 502 502 502 HIS HIS B . n B 1 503 ARG 503 503 503 ARG ARG B . n B 1 504 ALA 504 504 504 ALA ALA B . n B 1 505 ARG 505 505 505 ARG ARG B . n B 1 506 SER 506 506 506 SER SER B . n B 1 507 VAL 507 507 507 VAL VAL B . n B 1 508 ARG 508 508 508 ARG ARG B . n B 1 509 ALA 509 509 509 ALA ALA B . n B 1 510 ARG 510 510 510 ARG ARG B . n B 1 511 LEU 511 511 511 LEU LEU B . n B 1 512 LEU 512 512 512 LEU LEU B . n B 1 513 SER 513 513 513 SER SER B . n B 1 514 GLN 514 514 514 GLN GLN B . n B 1 515 GLY 515 515 515 GLY GLY B . n B 1 516 GLY 516 516 516 GLY GLY B . n B 1 517 ARG 517 517 517 ARG ARG B . n B 1 518 ALA 518 518 518 ALA ALA B . n B 1 519 ALA 519 519 519 ALA ALA B . n B 1 520 THR 520 520 520 THR THR B . n B 1 521 CYS 521 521 521 CYS CYS B . n B 1 522 GLY 522 522 522 GLY GLY B . n B 1 523 LYS 523 523 523 LYS LYS B . n B 1 524 TYR 524 524 524 TYR TYR B . n B 1 525 LEU 525 525 525 LEU LEU B . n B 1 526 PHE 526 526 526 PHE PHE B . n B 1 527 ASN 527 527 527 ASN ASN B . n B 1 528 TRP 528 528 528 TRP TRP B . n B 1 529 ALA 529 529 529 ALA ALA B . n B 1 530 VAL 530 530 530 VAL VAL B . n B 1 531 LYS 531 531 531 LYS LYS B . n B 1 532 THR 532 532 532 THR THR B . n B 1 533 LYS 533 533 533 LYS LYS B . n B 1 534 LEU 534 534 534 LEU LEU B . n B 1 535 LYS 535 535 535 LYS LYS B . n B 1 536 LEU 536 536 536 LEU LEU B . n B 1 537 THR 537 537 537 THR THR B . n B 1 538 PRO 538 538 538 PRO PRO B . n B 1 539 ILE 539 539 ? ? ? B . n B 1 540 PRO 540 540 ? ? ? B . n B 1 541 ALA 541 541 ? ? ? B . n B 1 542 ALA 542 542 ? ? ? B . n B 1 543 SER 543 543 ? ? ? B . n B 1 544 ARG 544 544 ? ? ? B . n B 1 545 LEU 545 545 ? ? ? B . n B 1 546 ASP 546 546 ? ? ? B . n B 1 547 LEU 547 547 ? ? ? B . n B 1 548 SER 548 548 ? ? ? B . n B 1 549 GLY 549 549 ? ? ? B . n B 1 550 TRP 550 550 ? ? ? B . n B 1 551 PHE 551 551 551 PHE PHE B . n B 1 552 VAL 552 552 552 VAL VAL B . n B 1 553 ALA 553 553 553 ALA ALA B . n B 1 554 GLY 554 554 554 GLY GLY B . n B 1 555 TYR 555 555 555 TYR TYR B . n B 1 556 SER 556 556 556 SER SER B . n B 1 557 GLY 557 557 557 GLY GLY B . n B 1 558 GLY 558 558 558 GLY GLY B . n B 1 559 ASP 559 559 559 ASP ASP B . n B 1 560 ILE 560 560 560 ILE ILE B . n B 1 561 TYR 561 561 561 TYR TYR B . n B 1 562 HIS 562 562 562 HIS HIS B . n B 1 563 SER 563 563 ? ? ? B . n B 1 564 LEU 564 564 ? ? ? B . n B 1 565 SER 565 565 ? ? ? B . n B 1 566 ARG 566 566 ? ? ? B . n B 1 567 ALA 567 567 ? ? ? B . n B 1 568 ARG 568 568 ? ? ? B . n B 1 569 PRO 569 569 ? ? ? B . n B 1 570 ARG 570 570 ? ? ? B . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code C 2 ZN 1 601 2 ZN ZN A . D 3 28L 1 602 1 28L DRG A . E 2 ZN 1 601 1 ZN ZN B . F 3 28L 1 602 1 28L DRG B . G 4 HOH 1 701 5 HOH HOH A . G 4 HOH 2 702 6 HOH HOH A . G 4 HOH 3 703 7 HOH HOH A . G 4 HOH 4 704 9 HOH HOH A . G 4 HOH 5 705 12 HOH HOH A . G 4 HOH 6 706 15 HOH HOH A . G 4 HOH 7 707 17 HOH HOH A . G 4 HOH 8 708 18 HOH HOH A . G 4 HOH 9 709 20 HOH HOH A . G 4 HOH 10 710 21 HOH HOH A . G 4 HOH 11 711 24 HOH HOH A . G 4 HOH 12 712 25 HOH HOH A . G 4 HOH 13 713 29 HOH HOH A . G 4 HOH 14 714 32 HOH HOH A . G 4 HOH 15 715 33 HOH HOH A . G 4 HOH 16 716 34 HOH HOH A . G 4 HOH 17 717 35 HOH HOH A . G 4 HOH 18 718 36 HOH HOH A . G 4 HOH 19 719 37 HOH HOH A . G 4 HOH 20 720 38 HOH HOH A . G 4 HOH 21 721 41 HOH HOH A . G 4 HOH 22 722 42 HOH HOH A . G 4 HOH 23 723 43 HOH HOH A . G 4 HOH 24 724 44 HOH HOH A . G 4 HOH 25 725 45 HOH HOH A . G 4 HOH 26 726 46 HOH HOH A . G 4 HOH 27 727 51 HOH HOH A . G 4 HOH 28 728 53 HOH HOH A . G 4 HOH 29 729 55 HOH HOH A . G 4 HOH 30 730 56 HOH HOH A . G 4 HOH 31 731 57 HOH HOH A . G 4 HOH 32 732 58 HOH HOH A . G 4 HOH 33 733 61 HOH HOH A . G 4 HOH 34 734 62 HOH HOH A . G 4 HOH 35 735 66 HOH HOH A . G 4 HOH 36 736 67 HOH HOH A . G 4 HOH 37 737 69 HOH HOH A . G 4 HOH 38 738 73 HOH HOH A . G 4 HOH 39 739 76 HOH HOH A . G 4 HOH 40 740 78 HOH HOH A . G 4 HOH 41 741 81 HOH HOH A . G 4 HOH 42 742 82 HOH HOH A . G 4 HOH 43 743 83 HOH HOH A . G 4 HOH 44 744 85 HOH HOH A . G 4 HOH 45 745 88 HOH HOH A . G 4 HOH 46 746 90 HOH HOH A . G 4 HOH 47 747 94 HOH HOH A . G 4 HOH 48 748 95 HOH HOH A . G 4 HOH 49 749 96 HOH HOH A . G 4 HOH 50 750 100 HOH HOH A . G 4 HOH 51 751 101 HOH HOH A . G 4 HOH 52 752 102 HOH HOH A . G 4 HOH 53 753 103 HOH HOH A . G 4 HOH 54 754 104 HOH HOH A . G 4 HOH 55 755 105 HOH HOH A . G 4 HOH 56 756 108 HOH HOH A . G 4 HOH 57 757 112 HOH HOH A . G 4 HOH 58 758 113 HOH HOH A . G 4 HOH 59 759 120 HOH HOH A . G 4 HOH 60 760 121 HOH HOH A . G 4 HOH 61 761 122 HOH HOH A . G 4 HOH 62 762 123 HOH HOH A . G 4 HOH 63 763 126 HOH HOH A . G 4 HOH 64 764 127 HOH HOH A . G 4 HOH 65 765 128 HOH HOH A . G 4 HOH 66 766 130 HOH HOH A . G 4 HOH 67 767 131 HOH HOH A . G 4 HOH 68 768 133 HOH HOH A . G 4 HOH 69 769 138 HOH HOH A . G 4 HOH 70 770 140 HOH HOH A . G 4 HOH 71 771 141 HOH HOH A . G 4 HOH 72 772 142 HOH HOH A . G 4 HOH 73 773 143 HOH HOH A . G 4 HOH 74 774 144 HOH HOH A . G 4 HOH 75 775 147 HOH HOH A . G 4 HOH 76 776 148 HOH HOH A . G 4 HOH 77 777 150 HOH HOH A . G 4 HOH 78 778 151 HOH HOH A . G 4 HOH 79 779 155 HOH HOH A . G 4 HOH 80 780 156 HOH HOH A . G 4 HOH 81 781 159 HOH HOH A . G 4 HOH 82 782 160 HOH HOH A . G 4 HOH 83 783 161 HOH HOH A . G 4 HOH 84 784 163 HOH HOH A . G 4 HOH 85 785 166 HOH HOH A . G 4 HOH 86 786 168 HOH HOH A . G 4 HOH 87 787 169 HOH HOH A . G 4 HOH 88 788 172 HOH HOH A . G 4 HOH 89 789 173 HOH HOH A . G 4 HOH 90 790 180 HOH HOH A . G 4 HOH 91 791 181 HOH HOH A . G 4 HOH 92 792 182 HOH HOH A . G 4 HOH 93 793 187 HOH HOH A . G 4 HOH 94 794 189 HOH HOH A . G 4 HOH 95 795 193 HOH HOH A . G 4 HOH 96 796 195 HOH HOH A . G 4 HOH 97 797 199 HOH HOH A . G 4 HOH 98 798 200 HOH HOH A . G 4 HOH 99 799 201 HOH HOH A . G 4 HOH 100 800 204 HOH HOH A . G 4 HOH 101 801 205 HOH HOH A . G 4 HOH 102 802 208 HOH HOH A . G 4 HOH 103 803 209 HOH HOH A . G 4 HOH 104 804 213 HOH HOH A . G 4 HOH 105 805 214 HOH HOH A . G 4 HOH 106 806 216 HOH HOH A . G 4 HOH 107 807 218 HOH HOH A . G 4 HOH 108 808 219 HOH HOH A . G 4 HOH 109 809 221 HOH HOH A . G 4 HOH 110 810 223 HOH HOH A . G 4 HOH 111 811 225 HOH HOH A . G 4 HOH 112 812 226 HOH HOH A . G 4 HOH 113 813 229 HOH HOH A . G 4 HOH 114 814 232 HOH HOH A . G 4 HOH 115 815 233 HOH HOH A . G 4 HOH 116 816 236 HOH HOH A . G 4 HOH 117 817 237 HOH HOH A . G 4 HOH 118 818 239 HOH HOH A . H 4 HOH 1 701 1 HOH HOH B . H 4 HOH 2 702 2 HOH HOH B . H 4 HOH 3 703 3 HOH HOH B . H 4 HOH 4 704 8 HOH HOH B . H 4 HOH 5 705 10 HOH HOH B . H 4 HOH 6 706 11 HOH HOH B . H 4 HOH 7 707 16 HOH HOH B . H 4 HOH 8 708 19 HOH HOH B . H 4 HOH 9 709 23 HOH HOH B . H 4 HOH 10 710 26 HOH HOH B . H 4 HOH 11 711 27 HOH HOH B . H 4 HOH 12 712 28 HOH HOH B . H 4 HOH 13 713 30 HOH HOH B . H 4 HOH 14 714 31 HOH HOH B . H 4 HOH 15 715 39 HOH HOH B . H 4 HOH 16 716 47 HOH HOH B . H 4 HOH 17 717 48 HOH HOH B . H 4 HOH 18 718 49 HOH HOH B . H 4 HOH 19 719 50 HOH HOH B . H 4 HOH 20 720 52 HOH HOH B . H 4 HOH 21 721 59 HOH HOH B . H 4 HOH 22 722 60 HOH HOH B . H 4 HOH 23 723 63 HOH HOH B . H 4 HOH 24 724 64 HOH HOH B . H 4 HOH 25 725 65 HOH HOH B . H 4 HOH 26 726 71 HOH HOH B . H 4 HOH 27 727 74 HOH HOH B . H 4 HOH 28 728 75 HOH HOH B . H 4 HOH 29 729 79 HOH HOH B . H 4 HOH 30 730 84 HOH HOH B . H 4 HOH 31 731 87 HOH HOH B . H 4 HOH 32 732 89 HOH HOH B . H 4 HOH 33 733 91 HOH HOH B . H 4 HOH 34 734 93 HOH HOH B . H 4 HOH 35 735 97 HOH HOH B . H 4 HOH 36 736 98 HOH HOH B . H 4 HOH 37 737 99 HOH HOH B . H 4 HOH 38 738 106 HOH HOH B . H 4 HOH 39 739 107 HOH HOH B . H 4 HOH 40 740 109 HOH HOH B . H 4 HOH 41 741 110 HOH HOH B . H 4 HOH 42 742 111 HOH HOH B . H 4 HOH 43 743 114 HOH HOH B . H 4 HOH 44 744 116 HOH HOH B . H 4 HOH 45 745 117 HOH HOH B . H 4 HOH 46 746 119 HOH HOH B . H 4 HOH 47 747 124 HOH HOH B . H 4 HOH 48 748 125 HOH HOH B . H 4 HOH 49 749 129 HOH HOH B . H 4 HOH 50 750 132 HOH HOH B . H 4 HOH 51 751 134 HOH HOH B . H 4 HOH 52 752 135 HOH HOH B . H 4 HOH 53 753 136 HOH HOH B . H 4 HOH 54 754 137 HOH HOH B . H 4 HOH 55 755 139 HOH HOH B . H 4 HOH 56 756 145 HOH HOH B . H 4 HOH 57 757 146 HOH HOH B . H 4 HOH 58 758 149 HOH HOH B . H 4 HOH 59 759 152 HOH HOH B . H 4 HOH 60 760 153 HOH HOH B . H 4 HOH 61 761 154 HOH HOH B . H 4 HOH 62 762 157 HOH HOH B . H 4 HOH 63 763 158 HOH HOH B . H 4 HOH 64 764 162 HOH HOH B . H 4 HOH 65 765 164 HOH HOH B . H 4 HOH 66 766 165 HOH HOH B . H 4 HOH 67 767 167 HOH HOH B . H 4 HOH 68 768 170 HOH HOH B . H 4 HOH 69 769 171 HOH HOH B . H 4 HOH 70 770 174 HOH HOH B . H 4 HOH 71 771 175 HOH HOH B . H 4 HOH 72 772 176 HOH HOH B . H 4 HOH 73 773 177 HOH HOH B . H 4 HOH 74 774 178 HOH HOH B . H 4 HOH 75 775 179 HOH HOH B . H 4 HOH 76 776 183 HOH HOH B . H 4 HOH 77 777 184 HOH HOH B . H 4 HOH 78 778 185 HOH HOH B . H 4 HOH 79 779 186 HOH HOH B . H 4 HOH 80 780 188 HOH HOH B . H 4 HOH 81 781 190 HOH HOH B . H 4 HOH 82 782 192 HOH HOH B . H 4 HOH 83 783 194 HOH HOH B . H 4 HOH 84 784 197 HOH HOH B . H 4 HOH 85 785 198 HOH HOH B . H 4 HOH 86 786 202 HOH HOH B . H 4 HOH 87 787 203 HOH HOH B . H 4 HOH 88 788 206 HOH HOH B . H 4 HOH 89 789 207 HOH HOH B . H 4 HOH 90 790 210 HOH HOH B . H 4 HOH 91 791 211 HOH HOH B . H 4 HOH 92 792 212 HOH HOH B . H 4 HOH 93 793 215 HOH HOH B . H 4 HOH 94 794 217 HOH HOH B . H 4 HOH 95 795 220 HOH HOH B . H 4 HOH 96 796 222 HOH HOH B . H 4 HOH 97 797 224 HOH HOH B . H 4 HOH 98 798 227 HOH HOH B . H 4 HOH 99 799 228 HOH HOH B . H 4 HOH 100 800 230 HOH HOH B . H 4 HOH 101 801 231 HOH HOH B . H 4 HOH 102 802 234 HOH HOH B . H 4 HOH 103 803 235 HOH HOH B . H 4 HOH 104 804 238 HOH HOH B . H 4 HOH 105 805 240 HOH HOH B . H 4 HOH 106 806 241 HOH HOH B . H 4 HOH 107 807 242 HOH HOH B . H 4 HOH 108 808 243 HOH HOH B . H 4 HOH 109 809 244 HOH HOH B . H 4 HOH 110 810 245 HOH HOH B . H 4 HOH 111 811 246 HOH HOH B . H 4 HOH 112 812 247 HOH HOH B . # loop_ _software.pdbx_ordinal _software.name _software.version _software.date _software.type _software.contact_author _software.contact_author_email _software.classification _software.location _software.language _software.citation_id 1 SCALEPACK . ? program 'Zbyszek Otwinowski' hkl@hkl-xray.com 'data scaling' http://www.hkl-xray.com/ ? ? 2 BUSTER-TNT 'BUSTER 2.11.4' ? program 'Gerard Bricogne' buster-develop@GlobalPhasing.com refinement http://www.globalphasing.com/buster/ ? ? 3 PDB_EXTRACT 3.11 'April 22, 2011' package PDB deposit@deposit.rcsb.org 'data extraction' http://sw-tools.pdb.org/apps/PDB_EXTRACT/ C++ ? 4 HKL-3000 . ? ? ? ? 'data reduction' ? ? ? 5 BUSTER 2.11.4 ? ? ? ? refinement ? ? ? # _cell.length_a 84.981 _cell.length_b 104.816 _cell.length_c 125.284 _cell.angle_alpha 90.000 _cell.angle_beta 90.000 _cell.angle_gamma 90.000 _cell.entry_id 4MIA _cell.pdbx_unique_axis ? _cell.Z_PDB 8 _cell.length_a_esd ? _cell.length_b_esd ? _cell.length_c_esd ? _cell.angle_alpha_esd ? _cell.angle_beta_esd ? _cell.angle_gamma_esd ? # _symmetry.space_group_name_H-M 'P 21 21 21' _symmetry.entry_id 4MIA _symmetry.Int_Tables_number 19 _symmetry.pdbx_full_space_group_name_H-M ? _symmetry.cell_setting ? _symmetry.space_group_name_Hall ? # _exptl.crystals_number 1 _exptl.entry_id 4MIA _exptl.method 'X-RAY DIFFRACTION' # _exptl_crystal.id 1 _exptl_crystal.density_Matthews 2.20 _exptl_crystal.density_meas ? _exptl_crystal.density_percent_sol 44.14 _exptl_crystal.description ? _exptl_crystal.F_000 ? _exptl_crystal.preparation ? # _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.method 'VAPOR DIFFUSION, SITTING DROP' _exptl_crystal_grow.pH 4.64 _exptl_crystal_grow.temp 292 _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.pdbx_details '24% peg 4000, 7.5% glycerol, 50 mM sodium citrate pH 4.64, VAPOR DIFFUSION, SITTING DROP, temperature 292K' _exptl_crystal_grow.pdbx_pH_range ? # _diffrn.id 1 _diffrn.ambient_temp 100 _diffrn.ambient_temp_details ? _diffrn.crystal_id 1 # _diffrn_detector.diffrn_id 1 _diffrn_detector.detector CCD _diffrn_detector.type 'ADSC QUANTUM 315' _diffrn_detector.pdbx_collection_date 2010-01-14 _diffrn_detector.details ? # _diffrn_radiation.diffrn_id 1 _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.monochromator ? _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength . _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.diffrn_id 1 _diffrn_source.source SYNCHROTRON _diffrn_source.type 'SSRL BEAMLINE BL7-1' _diffrn_source.pdbx_wavelength ? _diffrn_source.pdbx_wavelength_list ? _diffrn_source.pdbx_synchrotron_site SSRL _diffrn_source.pdbx_synchrotron_beamline BL7-1 # _reflns.entry_id 4MIA _reflns.d_resolution_high 2.800 _reflns.d_resolution_low 50.000 _reflns.number_obs 28541 _reflns.pdbx_Rmerge_I_obs 0.186 _reflns.pdbx_netI_over_sigmaI 4.300 _reflns.pdbx_chi_squared 1.038 _reflns.pdbx_redundancy 6.700 _reflns.percent_possible_obs 99.700 _reflns.B_iso_Wilson_estimate 63.070 _reflns.observed_criterion_sigma_F ? _reflns.observed_criterion_sigma_I ? _reflns.number_all ? _reflns.R_free_details ? _reflns.limit_h_max ? _reflns.limit_h_min ? _reflns.limit_k_max ? _reflns.limit_k_min ? _reflns.limit_l_max ? _reflns.limit_l_min ? _reflns.observed_criterion_F_max ? _reflns.observed_criterion_F_min ? _reflns.pdbx_scaling_rejects ? _reflns.pdbx_Rsym_value ? _reflns.pdbx_ordinal 1 _reflns.pdbx_diffrn_id 1 # loop_ _reflns_shell.d_res_high _reflns_shell.d_res_low _reflns_shell.number_measured_obs _reflns_shell.number_measured_all _reflns_shell.number_unique_obs _reflns_shell.Rmerge_I_obs _reflns_shell.meanI_over_sigI_obs _reflns_shell.pdbx_Rsym_value _reflns_shell.pdbx_chi_squared _reflns_shell.pdbx_redundancy _reflns_shell.percent_possible_obs _reflns_shell.number_unique_all _reflns_shell.percent_possible_all _reflns_shell.pdbx_ordinal _reflns_shell.pdbx_diffrn_id 2.800 2.900 ? ? ? 0.944 ? ? 0.982 5.600 ? 2765 99.000 1 1 2.900 3.020 ? ? ? 0.793 ? ? 1.020 6.500 ? 2814 99.500 2 1 3.020 3.150 ? ? ? 0.655 ? ? 1.055 6.800 ? 2815 99.500 3 1 3.150 3.320 ? ? ? 0.480 ? ? 1.055 6.900 ? 2812 99.800 4 1 3.320 3.530 ? ? ? 0.307 ? ? 1.055 7.000 ? 2819 99.900 5 1 3.530 3.800 ? ? ? 0.209 ? ? 1.045 7.000 ? 2833 100.000 6 1 3.800 4.180 ? ? ? 0.144 ? ? 1.026 7.000 ? 2845 100.000 7 1 4.180 4.790 ? ? ? 0.109 ? ? 1.018 7.000 ? 2891 100.000 8 1 4.790 6.030 ? ? ? 0.126 ? ? 1.079 6.900 ? 2903 100.000 9 1 6.030 50.000 ? ? ? 0.059 ? ? 1.032 6.500 ? 3044 99.500 10 1 # _refine.entry_id 4MIA _refine.ls_d_res_high 2.8000 _refine.ls_d_res_low 38.8000 _refine.pdbx_ls_sigma_F 0.000 _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.ls_percent_reflns_obs 99.7500 _refine.ls_number_reflns_obs 28155 _refine.ls_number_reflns_all ? _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.pdbx_R_Free_selection_details RANDOM _refine.details ? _refine.ls_R_factor_obs 0.2060 _refine.ls_R_factor_R_work 0.2021 _refine.ls_wR_factor_R_work ? _refine.ls_R_factor_R_free 0.2788 _refine.ls_wR_factor_R_free ? _refine.ls_percent_reflns_R_free 5.0900 _refine.ls_number_reflns_R_free 1432 _refine.ls_R_factor_R_free_error ? _refine.B_iso_mean 48.4331 _refine.solvent_model_param_bsol ? _refine.solvent_model_param_ksol ? _refine.pdbx_isotropic_thermal_model ? _refine.aniso_B[1][1] -0.2999 _refine.aniso_B[2][2] -5.3493 _refine.aniso_B[3][3] 5.6491 _refine.aniso_B[1][2] 0.0000 _refine.aniso_B[1][3] 0.0000 _refine.aniso_B[2][3] 0.0000 _refine.correlation_coeff_Fo_to_Fc 0.9277 _refine.correlation_coeff_Fo_to_Fc_free 0.8792 _refine.overall_SU_R_Cruickshank_DPI ? _refine.overall_SU_R_free ? _refine.pdbx_overall_ESU_R ? _refine.pdbx_overall_ESU_R_Free ? _refine.overall_SU_ML ? _refine.overall_SU_B ? _refine.solvent_model_details ? _refine.pdbx_solvent_vdw_probe_radii ? _refine.pdbx_solvent_ion_probe_radii ? _refine.pdbx_solvent_shrinkage_radii ? _refine.ls_number_parameters ? _refine.ls_number_restraints ? _refine.pdbx_starting_model ? _refine.pdbx_method_to_determine_struct 'FOURIER SYNTHESIS' _refine.pdbx_stereochemistry_target_values ? _refine.pdbx_stereochem_target_val_spec_case ? _refine.overall_FOM_work_R_set ? _refine.B_iso_max 210.420 _refine.B_iso_min 10.810 _refine.pdbx_overall_phase_error ? _refine.occupancy_max 1.000 _refine.occupancy_min 0.500 _refine.pdbx_ls_sigma_I ? _refine.ls_redundancy_reflns_obs ? _refine.ls_R_factor_R_free_error_details ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.overall_FOM_free_R_set ? _refine.ls_R_factor_all ? _refine.pdbx_diffrn_id 1 _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.pdbx_TLS_residual_ADP_flag ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? # _refine_analyze.entry_id 4MIA _refine_analyze.Luzzati_coordinate_error_obs 0.318 _refine_analyze.Luzzati_sigma_a_obs ? _refine_analyze.Luzzati_d_res_low_obs ? _refine_analyze.Luzzati_coordinate_error_free ? _refine_analyze.Luzzati_sigma_a_free ? _refine_analyze.Luzzati_d_res_low_free ? _refine_analyze.number_disordered_residues ? _refine_analyze.occupancy_sum_non_hydrogen ? _refine_analyze.occupancy_sum_hydrogen ? _refine_analyze.pdbx_Luzzati_d_res_high_obs ? _refine_analyze.pdbx_refine_id 'X-RAY DIFFRACTION' # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id LAST _refine_hist.pdbx_number_atoms_protein 8508 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 74 _refine_hist.number_atoms_solvent 230 _refine_hist.number_atoms_total 8812 _refine_hist.d_res_high 2.8000 _refine_hist.d_res_low 38.8000 # loop_ _refine_ls_restr.type _refine_ls_restr.number _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.weight _refine_ls_restr.pdbx_restraint_function _refine_ls_restr.pdbx_refine_id t_dihedral_angle_d 3063 ? ? 2.000 SINUSOIDAL 'X-RAY DIFFRACTION' t_trig_c_planes 170 ? ? 2.000 HARMONIC 'X-RAY DIFFRACTION' t_gen_planes 1373 ? ? 5.000 HARMONIC 'X-RAY DIFFRACTION' t_it 8866 ? ? 20.000 HARMONIC 'X-RAY DIFFRACTION' t_nbd 0 ? ? 5.000 SEMIHARMONIC 'X-RAY DIFFRACTION' t_chiral_improper_torsion 1166 ? ? 5.000 SEMIHARMONIC 'X-RAY DIFFRACTION' t_ideal_dist_contact 10836 ? ? 4.000 SEMIHARMONIC 'X-RAY DIFFRACTION' o_bond_d 8866 0.009 ? 2.000 HARMONIC 'X-RAY DIFFRACTION' o_angle_deg 12055 1.050 ? 2.000 HARMONIC 'X-RAY DIFFRACTION' t_omega_torsion ? 2.600 ? ? ? 'X-RAY DIFFRACTION' t_other_torsion ? 18.440 ? ? ? 'X-RAY DIFFRACTION' # _refine_ls_shell.d_res_high 2.8000 _refine_ls_shell.d_res_low 2.9100 _refine_ls_shell.pdbx_total_number_of_bins_used 14 _refine_ls_shell.percent_reflns_obs 99.7500 _refine_ls_shell.number_reflns_R_work 2756 _refine_ls_shell.R_factor_all 0.2260 _refine_ls_shell.R_factor_R_work 0.2227 _refine_ls_shell.R_factor_R_free 0.2882 _refine_ls_shell.percent_reflns_R_free 4.9700 _refine_ls_shell.number_reflns_R_free 144 _refine_ls_shell.R_factor_R_free_error ? _refine_ls_shell.number_reflns_all 2900 _refine_ls_shell.number_reflns_obs ? _refine_ls_shell.redundancy_reflns_obs ? _refine_ls_shell.pdbx_refine_id 'X-RAY DIFFRACTION' # _struct.entry_id 4MIA _struct.title ;Hepatitis C Virus polymerase NS5B genotype 1b (BK) in complex with RG7109 (N-{4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-2,5-dihydropyridin-3-yl)quinolin-3-yl]phenyl}methanesulfonamide) ; _struct.pdbx_model_details ? _struct.pdbx_CASP_flag ? _struct.pdbx_model_type_details ? # _struct_keywords.entry_id 4MIA _struct_keywords.pdbx_keywords 'TRANSFERASE/TRANSFERASE INHIBITOR' _struct_keywords.text 'polymerase, TRANSFERASE-TRANSFERASE INHIBITOR complex' # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 1 ? C N N 2 ? D N N 3 ? E N N 2 ? F N N 3 ? G N N 4 ? H N N 4 ? # _struct_ref.id 1 _struct_ref.db_name UNP _struct_ref.db_code POLG_HCVBK _struct_ref.pdbx_db_accession P26663 _struct_ref.entity_id 1 _struct_ref.pdbx_seq_one_letter_code ;MSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRSAGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAK LLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNEVFCVQPEKGGRKPARLIV FPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQYSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQ CCDLAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKASAACRAAKLQDCTMLVNGDDLV VICESAGTQEDAASLRVFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETAR HTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGE INRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASRLDLSGWFVAGYSGGDIY HSLSRARPR ; _struct_ref.pdbx_align_begin 2421 _struct_ref.pdbx_db_isoform ? # loop_ _struct_ref_seq.align_id _struct_ref_seq.ref_id _struct_ref_seq.pdbx_PDB_id_code _struct_ref_seq.pdbx_strand_id _struct_ref_seq.seq_align_beg _struct_ref_seq.pdbx_seq_align_beg_ins_code _struct_ref_seq.seq_align_end _struct_ref_seq.pdbx_seq_align_end_ins_code _struct_ref_seq.pdbx_db_accession _struct_ref_seq.db_align_beg _struct_ref_seq.pdbx_db_align_beg_ins_code _struct_ref_seq.db_align_end _struct_ref_seq.pdbx_db_align_end_ins_code _struct_ref_seq.pdbx_auth_seq_align_beg _struct_ref_seq.pdbx_auth_seq_align_end 1 1 4MIA A 2 ? 570 ? P26663 2421 ? 2989 ? 2 570 2 1 4MIA B 2 ? 570 ? P26663 2421 ? 2989 ? 2 570 # loop_ _struct_ref_seq_dif.align_id _struct_ref_seq_dif.pdbx_pdb_id_code _struct_ref_seq_dif.mon_id _struct_ref_seq_dif.pdbx_pdb_strand_id _struct_ref_seq_dif.seq_num _struct_ref_seq_dif.pdbx_pdb_ins_code _struct_ref_seq_dif.pdbx_seq_db_name _struct_ref_seq_dif.pdbx_seq_db_accession_code _struct_ref_seq_dif.db_mon_id _struct_ref_seq_dif.pdbx_seq_db_seq_num _struct_ref_seq_dif.details _struct_ref_seq_dif.pdbx_auth_seq_num _struct_ref_seq_dif.pdbx_ordinal 1 4MIA HIS A 1 ? UNP P26663 ? ? 'expression tag' 1 1 2 4MIA HIS B 1 ? UNP P26663 ? ? 'expression tag' 1 2 # loop_ _pdbx_struct_assembly.id _pdbx_struct_assembly.details _pdbx_struct_assembly.method_details _pdbx_struct_assembly.oligomeric_details _pdbx_struct_assembly.oligomeric_count 1 author_and_software_defined_assembly PISA monomeric 1 2 author_and_software_defined_assembly PISA monomeric 1 # loop_ _pdbx_struct_assembly_gen.assembly_id _pdbx_struct_assembly_gen.oper_expression _pdbx_struct_assembly_gen.asym_id_list 1 1 A,C,D,G 2 1 B,E,F,H # _pdbx_struct_oper_list.id 1 _pdbx_struct_oper_list.type 'identity operation' _pdbx_struct_oper_list.name 1_555 _pdbx_struct_oper_list.symmetry_operation x,y,z _pdbx_struct_oper_list.matrix[1][1] 1.0000000000 _pdbx_struct_oper_list.matrix[1][2] 0.0000000000 _pdbx_struct_oper_list.matrix[1][3] 0.0000000000 _pdbx_struct_oper_list.vector[1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][2] 1.0000000000 _pdbx_struct_oper_list.matrix[2][3] 0.0000000000 _pdbx_struct_oper_list.vector[2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][1] 0.0000000000 _pdbx_struct_oper_list.matrix[3][2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][3] 1.0000000000 _pdbx_struct_oper_list.vector[3] 0.0000000000 # _struct_biol.id 1 _struct_biol.details ? # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 1 LEU A 26 ? LEU A 30 ? LEU A 26 LEU A 30 5 ? 5 HELX_P HELX_P2 2 HIS A 33 ? ASN A 35 ? HIS A 33 ASN A 35 5 ? 3 HELX_P HELX_P3 3 SER A 44 ? THR A 53 ? SER A 44 THR A 53 1 ? 10 HELX_P HELX_P4 4 ASP A 61 ? SER A 76 ? ASP A 61 SER A 76 1 ? 16 HELX_P HELX_P5 5 SER A 84 ? LEU A 91 ? SER A 84 LEU A 91 1 ? 8 HELX_P HELX_P6 6 GLY A 104 ? ASN A 110 ? GLY A 104 ASN A 110 1 ? 7 HELX_P HELX_P7 7 SER A 112 ? ASP A 129 ? SER A 112 ASP A 129 1 ? 18 HELX_P HELX_P8 8 ASP A 164 ? GLY A 188 ? ASP A 164 GLY A 188 1 ? 25 HELX_P HELX_P9 9 SER A 189 ? TYR A 191 ? SER A 189 TYR A 191 5 ? 3 HELX_P HELX_P10 10 SER A 196 ? LYS A 211 ? SER A 196 LYS A 211 1 ? 16 HELX_P HELX_P11 11 CYS A 223 ? VAL A 228 ? CYS A 223 VAL A 228 1 ? 6 HELX_P HELX_P12 12 THR A 229 ? GLN A 241 ? THR A 229 GLN A 241 1 ? 13 HELX_P HELX_P13 13 ALA A 246 ? LEU A 260 ? ALA A 246 LEU A 260 1 ? 15 HELX_P HELX_P14 14 THR A 286 ? ALA A 306 ? THR A 286 ALA A 306 1 ? 21 HELX_P HELX_P15 15 GLY A 328 ? TYR A 346 ? GLY A 328 TYR A 346 1 ? 19 HELX_P HELX_P16 16 ASP A 359 ? ILE A 363 ? ASP A 359 ILE A 363 5 ? 5 HELX_P HELX_P17 17 PRO A 388 ? ARG A 401 ? PRO A 388 ARG A 401 1 ? 14 HELX_P HELX_P18 18 ASN A 406 ? TYR A 415 ? ASN A 406 TYR A 415 1 ? 10 HELX_P HELX_P19 19 THR A 418 ? ILE A 424 ? THR A 418 ILE A 424 1 ? 7 HELX_P HELX_P20 20 ILE A 424 ? GLN A 436 ? ILE A 424 GLN A 436 1 ? 13 HELX_P HELX_P21 21 GLU A 455 ? LEU A 457 ? GLU A 455 LEU A 457 5 ? 3 HELX_P HELX_P22 22 ASP A 458 ? GLY A 468 ? ASP A 458 GLY A 468 1 ? 11 HELX_P HELX_P23 23 LEU A 469 ? SER A 473 ? LEU A 469 SER A 473 5 ? 5 HELX_P HELX_P24 24 SER A 478 ? GLY A 493 ? SER A 478 GLY A 493 1 ? 16 HELX_P HELX_P25 25 PRO A 496 ? GLY A 515 ? PRO A 496 GLY A 515 1 ? 20 HELX_P HELX_P26 26 GLY A 516 ? PHE A 526 ? GLY A 516 PHE A 526 1 ? 11 HELX_P HELX_P27 27 LEU B 26 ? LEU B 30 ? LEU B 26 LEU B 30 5 ? 5 HELX_P HELX_P28 28 HIS B 33 ? ASN B 35 ? HIS B 33 ASN B 35 5 ? 3 HELX_P HELX_P29 29 THR B 41 ? ARG B 43 ? THR B 41 ARG B 43 5 ? 3 HELX_P HELX_P30 30 SER B 44 ? THR B 53 ? SER B 44 THR B 53 1 ? 10 HELX_P HELX_P31 31 ASP B 61 ? SER B 76 ? ASP B 61 SER B 76 1 ? 16 HELX_P HELX_P32 32 SER B 84 ? LEU B 91 ? SER B 84 LEU B 91 1 ? 8 HELX_P HELX_P33 33 GLY B 104 ? ASN B 110 ? GLY B 104 ASN B 110 1 ? 7 HELX_P HELX_P34 34 SER B 112 ? ASP B 129 ? SER B 112 ASP B 129 1 ? 18 HELX_P HELX_P35 35 ASP B 164 ? GLY B 188 ? ASP B 164 GLY B 188 1 ? 25 HELX_P HELX_P36 36 SER B 189 ? TYR B 191 ? SER B 189 TYR B 191 5 ? 3 HELX_P HELX_P37 37 SER B 196 ? LYS B 211 ? SER B 196 LYS B 211 1 ? 16 HELX_P HELX_P38 38 CYS B 223 ? VAL B 228 ? CYS B 223 VAL B 228 1 ? 6 HELX_P HELX_P39 39 THR B 229 ? GLN B 241 ? THR B 229 GLN B 241 1 ? 13 HELX_P HELX_P40 40 ALA B 246 ? LEU B 260 ? ALA B 246 LEU B 260 1 ? 15 HELX_P HELX_P41 41 THR B 286 ? LYS B 307 ? THR B 286 LYS B 307 1 ? 22 HELX_P HELX_P42 42 GLY B 328 ? TYR B 346 ? GLY B 328 TYR B 346 1 ? 19 HELX_P HELX_P43 43 ASP B 359 ? ILE B 363 ? ASP B 359 ILE B 363 5 ? 5 HELX_P HELX_P44 44 PRO B 388 ? ARG B 401 ? PRO B 388 ARG B 401 1 ? 14 HELX_P HELX_P45 45 ASN B 406 ? TYR B 415 ? ASN B 406 TYR B 415 1 ? 10 HELX_P HELX_P46 46 THR B 418 ? ILE B 424 ? THR B 418 ILE B 424 1 ? 7 HELX_P HELX_P47 47 ILE B 424 ? GLU B 437 ? ILE B 424 GLU B 437 1 ? 14 HELX_P HELX_P48 48 GLU B 455 ? LEU B 457 ? GLU B 455 LEU B 457 5 ? 3 HELX_P HELX_P49 49 ASP B 458 ? GLY B 468 ? ASP B 458 GLY B 468 1 ? 11 HELX_P HELX_P50 50 LEU B 469 ? SER B 473 ? LEU B 469 SER B 473 5 ? 5 HELX_P HELX_P51 51 SER B 478 ? GLY B 493 ? SER B 478 GLY B 493 1 ? 16 HELX_P HELX_P52 52 PRO B 496 ? GLY B 515 ? PRO B 496 GLY B 515 1 ? 20 HELX_P HELX_P53 53 GLY B 516 ? PHE B 526 ? GLY B 516 PHE B 526 1 ? 11 HELX_P HELX_P54 54 ASN B 527 ? VAL B 530 ? ASN B 527 VAL B 530 5 ? 4 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order _struct_conn.pdbx_role disulf1 disulf ? ? A CYS 303 SG ? ? ? 1_555 A CYS 311 SG ? ? A CYS 303 A CYS 311 1_555 ? ? ? ? ? ? ? 2.088 ? ? disulf2 disulf ? ? B CYS 303 SG ? ? ? 1_555 B CYS 311 SG ? ? B CYS 303 B CYS 311 1_555 ? ? ? ? ? ? ? 2.090 ? ? metalc1 metalc ? ? A ASP 66 OD2 ? ? ? 1_555 C ZN . ZN ? ? A ASP 66 A ZN 601 1_555 ? ? ? ? ? ? ? 1.890 ? ? metalc2 metalc ? ? B ASP 66 OD2 ? ? ? 1_555 E ZN . ZN ? ? B ASP 66 B ZN 601 1_555 ? ? ? ? ? ? ? 1.919 ? ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? metalc ? ? # loop_ _pdbx_modification_feature.ordinal _pdbx_modification_feature.label_comp_id _pdbx_modification_feature.label_asym_id _pdbx_modification_feature.label_seq_id _pdbx_modification_feature.label_alt_id _pdbx_modification_feature.modified_residue_label_comp_id _pdbx_modification_feature.modified_residue_label_asym_id _pdbx_modification_feature.modified_residue_label_seq_id _pdbx_modification_feature.modified_residue_label_alt_id _pdbx_modification_feature.auth_comp_id _pdbx_modification_feature.auth_asym_id _pdbx_modification_feature.auth_seq_id _pdbx_modification_feature.PDB_ins_code _pdbx_modification_feature.symmetry _pdbx_modification_feature.modified_residue_auth_comp_id _pdbx_modification_feature.modified_residue_auth_asym_id _pdbx_modification_feature.modified_residue_auth_seq_id _pdbx_modification_feature.modified_residue_PDB_ins_code _pdbx_modification_feature.modified_residue_symmetry _pdbx_modification_feature.comp_id_linking_atom _pdbx_modification_feature.modified_residue_id_linking_atom _pdbx_modification_feature.modified_residue_id _pdbx_modification_feature.ref_pcm_id _pdbx_modification_feature.ref_comp_id _pdbx_modification_feature.type _pdbx_modification_feature.category 1 CYS A 303 ? CYS A 311 ? CYS A 303 ? 1_555 CYS A 311 ? 1_555 SG SG . . . None 'Disulfide bridge' 2 CYS B 303 ? CYS B 311 ? CYS B 303 ? 1_555 CYS B 311 ? 1_555 SG SG . . . None 'Disulfide bridge' # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details A ? 5 ? B ? 2 ? C ? 3 ? D ? 2 ? E ? 3 ? F ? 5 ? G ? 2 ? H ? 3 ? I ? 2 ? J ? 3 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense A 1 2 ? anti-parallel A 2 3 ? anti-parallel A 3 4 ? parallel A 4 5 ? anti-parallel B 1 2 ? anti-parallel C 1 2 ? anti-parallel C 2 3 ? anti-parallel D 1 2 ? anti-parallel E 1 2 ? anti-parallel E 2 3 ? parallel F 1 2 ? anti-parallel F 2 3 ? anti-parallel F 3 4 ? parallel F 4 5 ? anti-parallel G 1 2 ? anti-parallel H 1 2 ? anti-parallel H 2 3 ? anti-parallel I 1 2 ? anti-parallel J 1 2 ? anti-parallel J 2 3 ? parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id A 1 TYR A 4 ? TRP A 6 ? TYR A 4 TRP A 6 A 2 ASN A 273 ? ARG A 277 ? ASN A 273 ARG A 277 A 3 GLY A 264 ? THR A 267 ? GLY A 264 THR A 267 A 4 THR A 136 ? ALA A 140 ? THR A 136 ALA A 140 A 5 LEU A 159 ? PRO A 163 ? LEU A 159 PRO A 163 B 1 VAL A 37 ? ALA A 39 ? VAL A 37 ALA A 39 B 2 VAL A 144 ? CYS A 146 ? VAL A 144 CYS A 146 C 1 PRO A 214 ? TYR A 219 ? PRO A 214 TYR A 219 C 2 ASP A 319 ? GLU A 325 ? ASP A 319 GLU A 325 C 3 THR A 312 ? ASN A 316 ? THR A 312 ASN A 316 D 1 SER A 368 ? HIS A 374 ? SER A 368 HIS A 374 D 2 ARG A 380 ? ARG A 386 ? ARG A 380 ARG A 386 E 1 LEU A 443 ? ILE A 447 ? LEU A 443 ILE A 447 E 2 ALA A 450 ? ILE A 454 ? ALA A 450 ILE A 454 E 3 TYR A 561 ? HIS A 562 ? TYR A 561 HIS A 562 F 1 TYR B 4 ? TRP B 6 ? TYR B 4 TRP B 6 F 2 ASN B 273 ? ARG B 277 ? ASN B 273 ARG B 277 F 3 GLY B 264 ? THR B 267 ? GLY B 264 THR B 267 F 4 THR B 136 ? ALA B 140 ? THR B 136 ALA B 140 F 5 LEU B 159 ? PRO B 163 ? LEU B 159 PRO B 163 G 1 VAL B 37 ? ALA B 39 ? VAL B 37 ALA B 39 G 2 VAL B 144 ? CYS B 146 ? VAL B 144 CYS B 146 H 1 PRO B 214 ? TYR B 219 ? PRO B 214 TYR B 219 H 2 ASP B 319 ? GLU B 325 ? ASP B 319 GLU B 325 H 3 GLN B 309 ? ASN B 316 ? GLN B 309 ASN B 316 I 1 SER B 368 ? HIS B 374 ? SER B 368 HIS B 374 I 2 ARG B 380 ? ARG B 386 ? ARG B 380 ARG B 386 J 1 LEU B 443 ? ILE B 447 ? LEU B 443 ILE B 447 J 2 ALA B 450 ? ILE B 454 ? ALA B 450 ILE B 454 J 3 TYR B 561 ? HIS B 562 ? TYR B 561 HIS B 562 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id A 1 2 N THR A 5 ? N THR A 5 O TYR A 276 ? O TYR A 276 A 2 3 O CYS A 274 ? O CYS A 274 N LEU A 266 ? N LEU A 266 A 3 4 O THR A 267 ? O THR A 267 N ILE A 138 ? N ILE A 138 A 4 5 N MET A 139 ? N MET A 139 O ILE A 160 ? O ILE A 160 B 1 2 N TYR A 38 ? N TYR A 38 O PHE A 145 ? O PHE A 145 C 1 2 N MET A 215 ? N MET A 215 O CYS A 324 ? O CYS A 324 C 2 3 O ASP A 319 ? O ASP A 319 N ASN A 316 ? N ASN A 316 D 1 2 N ALA A 373 ? N ALA A 373 O VAL A 381 ? O VAL A 381 E 1 2 N LEU A 443 ? N LEU A 443 O ILE A 454 ? O ILE A 454 E 2 3 N CYS A 451 ? N CYS A 451 O HIS A 562 ? O HIS A 562 F 1 2 N THR B 5 ? N THR B 5 O TYR B 276 ? O TYR B 276 F 2 3 O CYS B 274 ? O CYS B 274 N LEU B 266 ? N LEU B 266 F 3 4 O THR B 267 ? O THR B 267 N ILE B 138 ? N ILE B 138 F 4 5 N MET B 139 ? N MET B 139 O ILE B 160 ? O ILE B 160 G 1 2 N TYR B 38 ? N TYR B 38 O PHE B 145 ? O PHE B 145 H 1 2 N MET B 215 ? N MET B 215 O CYS B 324 ? O CYS B 324 H 2 3 O ASP B 319 ? O ASP B 319 N ASN B 316 ? N ASN B 316 I 1 2 N ALA B 373 ? N ALA B 373 O VAL B 381 ? O VAL B 381 J 1 2 N LEU B 443 ? N LEU B 443 O ILE B 454 ? O ILE B 454 J 2 3 N CYS B 451 ? N CYS B 451 O HIS B 562 ? O HIS B 562 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software A ZN 601 ? 2 'BINDING SITE FOR RESIDUE ZN A 601' AC2 Software A 28L 602 ? 17 'BINDING SITE FOR RESIDUE 28L A 602' AC3 Software B ZN 601 ? 2 'BINDING SITE FOR RESIDUE ZN B 601' AC4 Software B 28L 602 ? 16 'BINDING SITE FOR RESIDUE 28L B 602' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 2 ASP A 66 ? ASP A 66 . ? 1_555 ? 2 AC1 2 HIS B 1 ? HIS B 1 . ? 2_554 ? 3 AC2 17 PHE A 193 ? PHE A 193 . ? 1_555 ? 4 AC2 17 ARG A 200 ? ARG A 200 . ? 1_555 ? 5 AC2 17 ASN A 291 ? ASN A 291 . ? 1_555 ? 6 AC2 17 ASN A 316 ? ASN A 316 . ? 1_555 ? 7 AC2 17 GLY A 317 ? GLY A 317 . ? 1_555 ? 8 AC2 17 ASP A 318 ? ASP A 318 . ? 1_555 ? 9 AC2 17 CYS A 366 ? CYS A 366 . ? 1_555 ? 10 AC2 17 SER A 368 ? SER A 368 . ? 1_555 ? 11 AC2 17 SER A 407 ? SER A 407 . ? 1_555 ? 12 AC2 17 GLY A 410 ? GLY A 410 . ? 1_555 ? 13 AC2 17 ASN A 411 ? ASN A 411 . ? 1_555 ? 14 AC2 17 MET A 414 ? MET A 414 . ? 1_555 ? 15 AC2 17 TYR A 415 ? TYR A 415 . ? 1_555 ? 16 AC2 17 GLN A 446 ? GLN A 446 . ? 1_555 ? 17 AC2 17 ILE A 447 ? ILE A 447 . ? 1_555 ? 18 AC2 17 TYR A 448 ? TYR A 448 . ? 1_555 ? 19 AC2 17 SER A 556 ? SER A 556 . ? 1_555 ? 20 AC3 2 HIS A 1 ? HIS A 1 . ? 2_555 ? 21 AC3 2 ASP B 66 ? ASP B 66 . ? 1_555 ? 22 AC4 16 PHE B 193 ? PHE B 193 . ? 1_555 ? 23 AC4 16 SER B 288 ? SER B 288 . ? 1_555 ? 24 AC4 16 ASN B 291 ? ASN B 291 . ? 1_555 ? 25 AC4 16 ASN B 316 ? ASN B 316 . ? 1_555 ? 26 AC4 16 GLY B 317 ? GLY B 317 . ? 1_555 ? 27 AC4 16 ASP B 318 ? ASP B 318 . ? 1_555 ? 28 AC4 16 CYS B 366 ? CYS B 366 . ? 1_555 ? 29 AC4 16 ASN B 411 ? ASN B 411 . ? 1_555 ? 30 AC4 16 MET B 414 ? MET B 414 . ? 1_555 ? 31 AC4 16 TYR B 415 ? TYR B 415 . ? 1_555 ? 32 AC4 16 GLN B 446 ? GLN B 446 . ? 1_555 ? 33 AC4 16 ILE B 447 ? ILE B 447 . ? 1_555 ? 34 AC4 16 TYR B 448 ? TYR B 448 . ? 1_555 ? 35 AC4 16 SER B 556 ? SER B 556 . ? 1_555 ? 36 AC4 16 HOH H . ? HOH B 735 . ? 1_555 ? 37 AC4 16 HOH H . ? HOH B 796 . ? 1_555 ? # _pdbx_entry_details.entry_id 4MIA _pdbx_entry_details.compound_details ? _pdbx_entry_details.source_details ? _pdbx_entry_details.nonpolymer_details ? _pdbx_entry_details.sequence_details ? _pdbx_entry_details.has_ligand_of_interest ? _pdbx_entry_details.has_protein_modification Y # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 ALA A 15 ? ? -113.78 -163.59 2 1 LEU A 30 ? ? -120.24 -52.20 3 1 SER A 42 ? ? -59.23 -7.65 4 1 PHE A 101 ? ? -98.57 30.19 5 1 CYS A 223 ? A 43.47 72.65 6 1 CYS A 223 ? B 44.67 72.30 7 1 SER A 347 ? ? 70.05 55.72 8 1 ALA A 348 ? ? -152.26 60.42 9 1 SER A 367 ? ? 62.34 -0.88 10 1 ILE A 424 ? ? -92.49 -60.45 11 1 VAL A 552 ? ? -123.95 -53.47 12 1 ASP A 559 ? ? 61.62 64.93 13 1 ALA B 15 ? ? -112.82 -165.91 14 1 LEU B 30 ? ? -120.24 -52.18 15 1 PHE B 101 ? ? -96.76 31.30 16 1 CYS B 223 ? A 37.25 73.15 17 1 CYS B 279 ? ? -129.79 -166.95 18 1 ALA B 348 ? ? -152.35 60.17 19 1 LYS B 535 ? ? -68.04 97.94 20 1 ASP B 559 ? ? 61.46 64.81 # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 A PRO 149 ? A PRO 149 2 1 Y 1 A GLU 150 ? A GLU 150 3 1 Y 1 A LYS 151 ? A LYS 151 4 1 Y 1 A GLY 152 ? A GLY 152 5 1 Y 1 A GLY 153 ? A GLY 153 6 1 Y 1 A PRO 540 ? A PRO 540 7 1 Y 1 A ALA 541 ? A ALA 541 8 1 Y 1 A ALA 542 ? A ALA 542 9 1 Y 1 A SER 543 ? A SER 543 10 1 Y 1 A ARG 544 ? A ARG 544 11 1 Y 1 A LEU 545 ? A LEU 545 12 1 Y 1 A ASP 546 ? A ASP 546 13 1 Y 1 A LEU 547 ? A LEU 547 14 1 Y 1 A SER 548 ? A SER 548 15 1 Y 1 A GLY 549 ? A GLY 549 16 1 Y 1 A TRP 550 ? A TRP 550 17 1 Y 1 A SER 563 ? A SER 563 18 1 Y 1 A LEU 564 ? A LEU 564 19 1 Y 1 A SER 565 ? A SER 565 20 1 Y 1 A ARG 566 ? A ARG 566 21 1 Y 1 A ALA 567 ? A ALA 567 22 1 Y 1 A ARG 568 ? A ARG 568 23 1 Y 1 A PRO 569 ? A PRO 569 24 1 Y 1 A ARG 570 ? A ARG 570 25 1 Y 1 B PRO 149 ? B PRO 149 26 1 Y 1 B GLU 150 ? B GLU 150 27 1 Y 1 B LYS 151 ? B LYS 151 28 1 Y 1 B GLY 152 ? B GLY 152 29 1 Y 1 B GLY 153 ? B GLY 153 30 1 Y 1 B ILE 539 ? B ILE 539 31 1 Y 1 B PRO 540 ? B PRO 540 32 1 Y 1 B ALA 541 ? B ALA 541 33 1 Y 1 B ALA 542 ? B ALA 542 34 1 Y 1 B SER 543 ? B SER 543 35 1 Y 1 B ARG 544 ? B ARG 544 36 1 Y 1 B LEU 545 ? B LEU 545 37 1 Y 1 B ASP 546 ? B ASP 546 38 1 Y 1 B LEU 547 ? B LEU 547 39 1 Y 1 B SER 548 ? B SER 548 40 1 Y 1 B GLY 549 ? B GLY 549 41 1 Y 1 B TRP 550 ? B TRP 550 42 1 Y 1 B SER 563 ? B SER 563 43 1 Y 1 B LEU 564 ? B LEU 564 44 1 Y 1 B SER 565 ? B SER 565 45 1 Y 1 B ARG 566 ? B ARG 566 46 1 Y 1 B ALA 567 ? B ALA 567 47 1 Y 1 B ARG 568 ? B ARG 568 48 1 Y 1 B PRO 569 ? B PRO 569 49 1 Y 1 B ARG 570 ? B ARG 570 # loop_ _chem_comp_atom.comp_id _chem_comp_atom.atom_id _chem_comp_atom.type_symbol _chem_comp_atom.pdbx_aromatic_flag _chem_comp_atom.pdbx_stereo_config _chem_comp_atom.pdbx_ordinal 28L C1 C N N 1 28L S2 S N N 2 28L N3 N N N 3 28L C4 C Y N 4 28L C5 C Y N 5 28L C6 C Y N 6 28L C7 C Y N 7 28L C8 C Y N 8 28L C9 C Y N 9 28L C10 C Y N 10 28L C11 C Y N 11 28L N12 N Y N 12 28L C13 C Y N 13 28L C14 C Y N 14 28L C15 C Y N 15 28L C16 C Y N 16 28L C17 C N N 17 28L C18 C N N 18 28L C19 C N N 19 28L C20 C N N 20 28L O21 O N N 21 28L C22 C N N 22 28L N23 N N N 23 28L C24 C N N 24 28L O25 O N N 25 28L C26 C Y N 26 28L C27 C Y N 27 28L C28 C N N 28 28L C29 C N N 29 28L C30 C N N 30 28L C31 C N N 31 28L C32 C Y N 32 28L O33 O N N 33 28L C34 C N N 34 28L O35 O N N 35 28L O36 O N N 36 28L H1 H N N 37 28L H2 H N N 38 28L H3 H N N 39 28L H4 H N N 40 28L H5 H N N 41 28L H6 H N N 42 28L H7 H N N 43 28L H8 H N N 44 28L H9 H N N 45 28L H10 H N N 46 28L H11 H N N 47 28L H12 H N N 48 28L H13 H N N 49 28L H14 H N N 50 28L H15 H N N 51 28L H16 H N N 52 28L H17 H N N 53 28L H18 H N N 54 28L H19 H N N 55 28L H20 H N N 56 28L H21 H N N 57 28L H22 H N N 58 28L H23 H N N 59 28L H24 H N N 60 28L H25 H N N 61 28L H26 H N N 62 28L H27 H N N 63 28L H28 H N N 64 28L H29 H N N 65 ALA N N N N 66 ALA CA C N S 67 ALA C C N N 68 ALA O O N N 69 ALA CB C N N 70 ALA OXT O N N 71 ALA H H N N 72 ALA H2 H N N 73 ALA HA H N N 74 ALA HB1 H N N 75 ALA HB2 H N N 76 ALA HB3 H N N 77 ALA HXT H N N 78 ARG N N N N 79 ARG CA C N S 80 ARG C C N N 81 ARG O O N N 82 ARG CB C N N 83 ARG CG C N N 84 ARG CD C N N 85 ARG NE N N N 86 ARG CZ C N N 87 ARG NH1 N N N 88 ARG NH2 N N N 89 ARG OXT O N N 90 ARG H H N N 91 ARG H2 H N N 92 ARG HA H N N 93 ARG HB2 H N N 94 ARG HB3 H N N 95 ARG HG2 H N N 96 ARG HG3 H N N 97 ARG HD2 H N N 98 ARG HD3 H N N 99 ARG HE H N N 100 ARG HH11 H N N 101 ARG HH12 H N N 102 ARG HH21 H N N 103 ARG HH22 H N N 104 ARG HXT H N N 105 ASN N N N N 106 ASN CA C N S 107 ASN C C N N 108 ASN O O N N 109 ASN CB C N N 110 ASN CG C N N 111 ASN OD1 O N N 112 ASN ND2 N N N 113 ASN OXT O N N 114 ASN H H N N 115 ASN H2 H N N 116 ASN HA H N N 117 ASN HB2 H N N 118 ASN HB3 H N N 119 ASN HD21 H N N 120 ASN HD22 H N N 121 ASN HXT H N N 122 ASP N N N N 123 ASP CA C N S 124 ASP C C N N 125 ASP O O N N 126 ASP CB C N N 127 ASP CG C N N 128 ASP OD1 O N N 129 ASP OD2 O N N 130 ASP OXT O N N 131 ASP H H N N 132 ASP H2 H N N 133 ASP HA H N N 134 ASP HB2 H N N 135 ASP HB3 H N N 136 ASP HD2 H N N 137 ASP HXT H N N 138 CYS N N N N 139 CYS CA C N R 140 CYS C C N N 141 CYS O O N N 142 CYS CB C N N 143 CYS SG S N N 144 CYS OXT O N N 145 CYS H H N N 146 CYS H2 H N N 147 CYS HA H N N 148 CYS HB2 H N N 149 CYS HB3 H N N 150 CYS HG H N N 151 CYS HXT H N N 152 GLN N N N N 153 GLN CA C N S 154 GLN C C N N 155 GLN O O N N 156 GLN CB C N N 157 GLN CG C N N 158 GLN CD C N N 159 GLN OE1 O N N 160 GLN NE2 N N N 161 GLN OXT O N N 162 GLN H H N N 163 GLN H2 H N N 164 GLN HA H N N 165 GLN HB2 H N N 166 GLN HB3 H N N 167 GLN HG2 H N N 168 GLN HG3 H N N 169 GLN HE21 H N N 170 GLN HE22 H N N 171 GLN HXT H N N 172 GLU N N N N 173 GLU CA C N S 174 GLU C C N N 175 GLU O O N N 176 GLU CB C N N 177 GLU CG C N N 178 GLU CD C N N 179 GLU OE1 O N N 180 GLU OE2 O N N 181 GLU OXT O N N 182 GLU H H N N 183 GLU H2 H N N 184 GLU HA H N N 185 GLU HB2 H N N 186 GLU HB3 H N N 187 GLU HG2 H N N 188 GLU HG3 H N N 189 GLU HE2 H N N 190 GLU HXT H N N 191 GLY N N N N 192 GLY CA C N N 193 GLY C C N N 194 GLY O O N N 195 GLY OXT O N N 196 GLY H H N N 197 GLY H2 H N N 198 GLY HA2 H N N 199 GLY HA3 H N N 200 GLY HXT H N N 201 HIS N N N N 202 HIS CA C N S 203 HIS C C N N 204 HIS O O N N 205 HIS CB C N N 206 HIS CG C Y N 207 HIS ND1 N Y N 208 HIS CD2 C Y N 209 HIS CE1 C Y N 210 HIS NE2 N Y N 211 HIS OXT O N N 212 HIS H H N N 213 HIS H2 H N N 214 HIS HA H N N 215 HIS HB2 H N N 216 HIS HB3 H N N 217 HIS HD1 H N N 218 HIS HD2 H N N 219 HIS HE1 H N N 220 HIS HE2 H N N 221 HIS HXT H N N 222 HOH O O N N 223 HOH H1 H N N 224 HOH H2 H N N 225 ILE N N N N 226 ILE CA C N S 227 ILE C C N N 228 ILE O O N N 229 ILE CB C N S 230 ILE CG1 C N N 231 ILE CG2 C N N 232 ILE CD1 C N N 233 ILE OXT O N N 234 ILE H H N N 235 ILE H2 H N N 236 ILE HA H N N 237 ILE HB H N N 238 ILE HG12 H N N 239 ILE HG13 H N N 240 ILE HG21 H N N 241 ILE HG22 H N N 242 ILE HG23 H N N 243 ILE HD11 H N N 244 ILE HD12 H N N 245 ILE HD13 H N N 246 ILE HXT H N N 247 LEU N N N N 248 LEU CA C N S 249 LEU C C N N 250 LEU O O N N 251 LEU CB C N N 252 LEU CG C N N 253 LEU CD1 C N N 254 LEU CD2 C N N 255 LEU OXT O N N 256 LEU H H N N 257 LEU H2 H N N 258 LEU HA H N N 259 LEU HB2 H N N 260 LEU HB3 H N N 261 LEU HG H N N 262 LEU HD11 H N N 263 LEU HD12 H N N 264 LEU HD13 H N N 265 LEU HD21 H N N 266 LEU HD22 H N N 267 LEU HD23 H N N 268 LEU HXT H N N 269 LYS N N N N 270 LYS CA C N S 271 LYS C C N N 272 LYS O O N N 273 LYS CB C N N 274 LYS CG C N N 275 LYS CD C N N 276 LYS CE C N N 277 LYS NZ N N N 278 LYS OXT O N N 279 LYS H H N N 280 LYS H2 H N N 281 LYS HA H N N 282 LYS HB2 H N N 283 LYS HB3 H N N 284 LYS HG2 H N N 285 LYS HG3 H N N 286 LYS HD2 H N N 287 LYS HD3 H N N 288 LYS HE2 H N N 289 LYS HE3 H N N 290 LYS HZ1 H N N 291 LYS HZ2 H N N 292 LYS HZ3 H N N 293 LYS HXT H N N 294 MET N N N N 295 MET CA C N S 296 MET C C N N 297 MET O O N N 298 MET CB C N N 299 MET CG C N N 300 MET SD S N N 301 MET CE C N N 302 MET OXT O N N 303 MET H H N N 304 MET H2 H N N 305 MET HA H N N 306 MET HB2 H N N 307 MET HB3 H N N 308 MET HG2 H N N 309 MET HG3 H N N 310 MET HE1 H N N 311 MET HE2 H N N 312 MET HE3 H N N 313 MET HXT H N N 314 PHE N N N N 315 PHE CA C N S 316 PHE C C N N 317 PHE O O N N 318 PHE CB C N N 319 PHE CG C Y N 320 PHE CD1 C Y N 321 PHE CD2 C Y N 322 PHE CE1 C Y N 323 PHE CE2 C Y N 324 PHE CZ C Y N 325 PHE OXT O N N 326 PHE H H N N 327 PHE H2 H N N 328 PHE HA H N N 329 PHE HB2 H N N 330 PHE HB3 H N N 331 PHE HD1 H N N 332 PHE HD2 H N N 333 PHE HE1 H N N 334 PHE HE2 H N N 335 PHE HZ H N N 336 PHE HXT H N N 337 PRO N N N N 338 PRO CA C N S 339 PRO C C N N 340 PRO O O N N 341 PRO CB C N N 342 PRO CG C N N 343 PRO CD C N N 344 PRO OXT O N N 345 PRO H H N N 346 PRO HA H N N 347 PRO HB2 H N N 348 PRO HB3 H N N 349 PRO HG2 H N N 350 PRO HG3 H N N 351 PRO HD2 H N N 352 PRO HD3 H N N 353 PRO HXT H N N 354 SER N N N N 355 SER CA C N S 356 SER C C N N 357 SER O O N N 358 SER CB C N N 359 SER OG O N N 360 SER OXT O N N 361 SER H H N N 362 SER H2 H N N 363 SER HA H N N 364 SER HB2 H N N 365 SER HB3 H N N 366 SER HG H N N 367 SER HXT H N N 368 THR N N N N 369 THR CA C N S 370 THR C C N N 371 THR O O N N 372 THR CB C N R 373 THR OG1 O N N 374 THR CG2 C N N 375 THR OXT O N N 376 THR H H N N 377 THR H2 H N N 378 THR HA H N N 379 THR HB H N N 380 THR HG1 H N N 381 THR HG21 H N N 382 THR HG22 H N N 383 THR HG23 H N N 384 THR HXT H N N 385 TRP N N N N 386 TRP CA C N S 387 TRP C C N N 388 TRP O O N N 389 TRP CB C N N 390 TRP CG C Y N 391 TRP CD1 C Y N 392 TRP CD2 C Y N 393 TRP NE1 N Y N 394 TRP CE2 C Y N 395 TRP CE3 C Y N 396 TRP CZ2 C Y N 397 TRP CZ3 C Y N 398 TRP CH2 C Y N 399 TRP OXT O N N 400 TRP H H N N 401 TRP H2 H N N 402 TRP HA H N N 403 TRP HB2 H N N 404 TRP HB3 H N N 405 TRP HD1 H N N 406 TRP HE1 H N N 407 TRP HE3 H N N 408 TRP HZ2 H N N 409 TRP HZ3 H N N 410 TRP HH2 H N N 411 TRP HXT H N N 412 TYR N N N N 413 TYR CA C N S 414 TYR C C N N 415 TYR O O N N 416 TYR CB C N N 417 TYR CG C Y N 418 TYR CD1 C Y N 419 TYR CD2 C Y N 420 TYR CE1 C Y N 421 TYR CE2 C Y N 422 TYR CZ C Y N 423 TYR OH O N N 424 TYR OXT O N N 425 TYR H H N N 426 TYR H2 H N N 427 TYR HA H N N 428 TYR HB2 H N N 429 TYR HB3 H N N 430 TYR HD1 H N N 431 TYR HD2 H N N 432 TYR HE1 H N N 433 TYR HE2 H N N 434 TYR HH H N N 435 TYR HXT H N N 436 VAL N N N N 437 VAL CA C N S 438 VAL C C N N 439 VAL O O N N 440 VAL CB C N N 441 VAL CG1 C N N 442 VAL CG2 C N N 443 VAL OXT O N N 444 VAL H H N N 445 VAL H2 H N N 446 VAL HA H N N 447 VAL HB H N N 448 VAL HG11 H N N 449 VAL HG12 H N N 450 VAL HG13 H N N 451 VAL HG21 H N N 452 VAL HG22 H N N 453 VAL HG23 H N N 454 VAL HXT H N N 455 ZN ZN ZN N N 456 # loop_ _chem_comp_bond.comp_id _chem_comp_bond.atom_id_1 _chem_comp_bond.atom_id_2 _chem_comp_bond.value_order _chem_comp_bond.pdbx_aromatic_flag _chem_comp_bond.pdbx_stereo_config _chem_comp_bond.pdbx_ordinal 28L C29 C28 sing N N 1 28L O21 C22 sing N N 2 28L O21 C20 sing N N 3 28L C19 C20 sing N N 4 28L C19 C18 sing N N 5 28L C20 N23 doub N N 6 28L C18 C17 doub N N 7 28L N23 C24 sing N N 8 28L C28 C30 sing N N 9 28L C28 C31 sing N N 10 28L C28 C27 sing N N 11 28L C17 C24 sing N N 12 28L C17 C16 sing N N 13 28L C26 C27 doub Y N 14 28L C26 C16 sing Y N 15 28L C24 O25 doub N N 16 28L C27 C32 sing Y N 17 28L C16 C15 doub Y N 18 28L C32 O33 sing N N 19 28L C32 C14 doub Y N 20 28L C15 C14 sing Y N 21 28L C15 N12 sing Y N 22 28L O33 C34 sing N N 23 28L C14 C13 sing Y N 24 28L N12 C11 doub Y N 25 28L C11 C10 sing Y N 26 28L C13 C10 doub Y N 27 28L C10 C9 sing N N 28 28L C9 C8 doub Y N 29 28L C9 C6 sing Y N 30 28L C8 C7 sing Y N 31 28L C6 C5 doub Y N 32 28L C7 C4 doub Y N 33 28L C5 C4 sing Y N 34 28L C4 N3 sing N N 35 28L N3 S2 sing N N 36 28L O36 S2 doub N N 37 28L C1 S2 sing N N 38 28L S2 O35 doub N N 39 28L C1 H1 sing N N 40 28L C1 H2 sing N N 41 28L C1 H3 sing N N 42 28L N3 H4 sing N N 43 28L C5 H5 sing N N 44 28L C6 H6 sing N N 45 28L C7 H7 sing N N 46 28L C8 H8 sing N N 47 28L C11 H9 sing N N 48 28L C13 H10 sing N N 49 28L C18 H11 sing N N 50 28L C19 H12 sing N N 51 28L C19 H13 sing N N 52 28L C22 H14 sing N N 53 28L C22 H15 sing N N 54 28L C22 H16 sing N N 55 28L C26 H17 sing N N 56 28L C29 H18 sing N N 57 28L C29 H19 sing N N 58 28L C29 H20 sing N N 59 28L C30 H21 sing N N 60 28L C30 H22 sing N N 61 28L C30 H23 sing N N 62 28L C31 H24 sing N N 63 28L C31 H25 sing N N 64 28L C31 H26 sing N N 65 28L C34 H27 sing N N 66 28L C34 H28 sing N N 67 28L C34 H29 sing N N 68 ALA N CA sing N N 69 ALA N H sing N N 70 ALA N H2 sing N N 71 ALA CA C sing N N 72 ALA CA CB sing N N 73 ALA CA HA sing N N 74 ALA C O doub N N 75 ALA C OXT sing N N 76 ALA CB HB1 sing N N 77 ALA CB HB2 sing N N 78 ALA CB HB3 sing N N 79 ALA OXT HXT sing N N 80 ARG N CA sing N N 81 ARG N H sing N N 82 ARG N H2 sing N N 83 ARG CA C sing N N 84 ARG CA CB sing N N 85 ARG CA HA sing N N 86 ARG C O doub N N 87 ARG C OXT sing N N 88 ARG CB CG sing N N 89 ARG CB HB2 sing N N 90 ARG CB HB3 sing N N 91 ARG CG CD sing N N 92 ARG CG HG2 sing N N 93 ARG CG HG3 sing N N 94 ARG CD NE sing N N 95 ARG CD HD2 sing N N 96 ARG CD HD3 sing N N 97 ARG NE CZ sing N N 98 ARG NE HE sing N N 99 ARG CZ NH1 sing N N 100 ARG CZ NH2 doub N N 101 ARG NH1 HH11 sing N N 102 ARG NH1 HH12 sing N N 103 ARG NH2 HH21 sing N N 104 ARG NH2 HH22 sing N N 105 ARG OXT HXT sing N N 106 ASN N CA sing N N 107 ASN N H sing N N 108 ASN N H2 sing N N 109 ASN CA C sing N N 110 ASN CA CB sing N N 111 ASN CA HA sing N N 112 ASN C O doub N N 113 ASN C OXT sing N N 114 ASN CB CG sing N N 115 ASN CB HB2 sing N N 116 ASN CB HB3 sing N N 117 ASN CG OD1 doub N N 118 ASN CG ND2 sing N N 119 ASN ND2 HD21 sing N N 120 ASN ND2 HD22 sing N N 121 ASN OXT HXT sing N N 122 ASP N CA sing N N 123 ASP N H sing N N 124 ASP N H2 sing N N 125 ASP CA C sing N N 126 ASP CA CB sing N N 127 ASP CA HA sing N N 128 ASP C O doub N N 129 ASP C OXT sing N N 130 ASP CB CG sing N N 131 ASP CB HB2 sing N N 132 ASP CB HB3 sing N N 133 ASP CG OD1 doub N N 134 ASP CG OD2 sing N N 135 ASP OD2 HD2 sing N N 136 ASP OXT HXT sing N N 137 CYS N CA sing N N 138 CYS N H sing N N 139 CYS N H2 sing N N 140 CYS CA C sing N N 141 CYS CA CB sing N N 142 CYS CA HA sing N N 143 CYS C O doub N N 144 CYS C OXT sing N N 145 CYS CB SG sing N N 146 CYS CB HB2 sing N N 147 CYS CB HB3 sing N N 148 CYS SG HG sing N N 149 CYS OXT HXT sing N N 150 GLN N CA sing N N 151 GLN N H sing N N 152 GLN N H2 sing N N 153 GLN CA C sing N N 154 GLN CA CB sing N N 155 GLN CA HA sing N N 156 GLN C O doub N N 157 GLN C OXT sing N N 158 GLN CB CG sing N N 159 GLN CB HB2 sing N N 160 GLN CB HB3 sing N N 161 GLN CG CD sing N N 162 GLN CG HG2 sing N N 163 GLN CG HG3 sing N N 164 GLN CD OE1 doub N N 165 GLN CD NE2 sing N N 166 GLN NE2 HE21 sing N N 167 GLN NE2 HE22 sing N N 168 GLN OXT HXT sing N N 169 GLU N CA sing N N 170 GLU N H sing N N 171 GLU N H2 sing N N 172 GLU CA C sing N N 173 GLU CA CB sing N N 174 GLU CA HA sing N N 175 GLU C O doub N N 176 GLU C OXT sing N N 177 GLU CB CG sing N N 178 GLU CB HB2 sing N N 179 GLU CB HB3 sing N N 180 GLU CG CD sing N N 181 GLU CG HG2 sing N N 182 GLU CG HG3 sing N N 183 GLU CD OE1 doub N N 184 GLU CD OE2 sing N N 185 GLU OE2 HE2 sing N N 186 GLU OXT HXT sing N N 187 GLY N CA sing N N 188 GLY N H sing N N 189 GLY N H2 sing N N 190 GLY CA C sing N N 191 GLY CA HA2 sing N N 192 GLY CA HA3 sing N N 193 GLY C O doub N N 194 GLY C OXT sing N N 195 GLY OXT HXT sing N N 196 HIS N CA sing N N 197 HIS N H sing N N 198 HIS N H2 sing N N 199 HIS CA C sing N N 200 HIS CA CB sing N N 201 HIS CA HA sing N N 202 HIS C O doub N N 203 HIS C OXT sing N N 204 HIS CB CG sing N N 205 HIS CB HB2 sing N N 206 HIS CB HB3 sing N N 207 HIS CG ND1 sing Y N 208 HIS CG CD2 doub Y N 209 HIS ND1 CE1 doub Y N 210 HIS ND1 HD1 sing N N 211 HIS CD2 NE2 sing Y N 212 HIS CD2 HD2 sing N N 213 HIS CE1 NE2 sing Y N 214 HIS CE1 HE1 sing N N 215 HIS NE2 HE2 sing N N 216 HIS OXT HXT sing N N 217 HOH O H1 sing N N 218 HOH O H2 sing N N 219 ILE N CA sing N N 220 ILE N H sing N N 221 ILE N H2 sing N N 222 ILE CA C sing N N 223 ILE CA CB sing N N 224 ILE CA HA sing N N 225 ILE C O doub N N 226 ILE C OXT sing N N 227 ILE CB CG1 sing N N 228 ILE CB CG2 sing N N 229 ILE CB HB sing N N 230 ILE CG1 CD1 sing N N 231 ILE CG1 HG12 sing N N 232 ILE CG1 HG13 sing N N 233 ILE CG2 HG21 sing N N 234 ILE CG2 HG22 sing N N 235 ILE CG2 HG23 sing N N 236 ILE CD1 HD11 sing N N 237 ILE CD1 HD12 sing N N 238 ILE CD1 HD13 sing N N 239 ILE OXT HXT sing N N 240 LEU N CA sing N N 241 LEU N H sing N N 242 LEU N H2 sing N N 243 LEU CA C sing N N 244 LEU CA CB sing N N 245 LEU CA HA sing N N 246 LEU C O doub N N 247 LEU C OXT sing N N 248 LEU CB CG sing N N 249 LEU CB HB2 sing N N 250 LEU CB HB3 sing N N 251 LEU CG CD1 sing N N 252 LEU CG CD2 sing N N 253 LEU CG HG sing N N 254 LEU CD1 HD11 sing N N 255 LEU CD1 HD12 sing N N 256 LEU CD1 HD13 sing N N 257 LEU CD2 HD21 sing N N 258 LEU CD2 HD22 sing N N 259 LEU CD2 HD23 sing N N 260 LEU OXT HXT sing N N 261 LYS N CA sing N N 262 LYS N H sing N N 263 LYS N H2 sing N N 264 LYS CA C sing N N 265 LYS CA CB sing N N 266 LYS CA HA sing N N 267 LYS C O doub N N 268 LYS C OXT sing N N 269 LYS CB CG sing N N 270 LYS CB HB2 sing N N 271 LYS CB HB3 sing N N 272 LYS CG CD sing N N 273 LYS CG HG2 sing N N 274 LYS CG HG3 sing N N 275 LYS CD CE sing N N 276 LYS CD HD2 sing N N 277 LYS CD HD3 sing N N 278 LYS CE NZ sing N N 279 LYS CE HE2 sing N N 280 LYS CE HE3 sing N N 281 LYS NZ HZ1 sing N N 282 LYS NZ HZ2 sing N N 283 LYS NZ HZ3 sing N N 284 LYS OXT HXT sing N N 285 MET N CA sing N N 286 MET N H sing N N 287 MET N H2 sing N N 288 MET CA C sing N N 289 MET CA CB sing N N 290 MET CA HA sing N N 291 MET C O doub N N 292 MET C OXT sing N N 293 MET CB CG sing N N 294 MET CB HB2 sing N N 295 MET CB HB3 sing N N 296 MET CG SD sing N N 297 MET CG HG2 sing N N 298 MET CG HG3 sing N N 299 MET SD CE sing N N 300 MET CE HE1 sing N N 301 MET CE HE2 sing N N 302 MET CE HE3 sing N N 303 MET OXT HXT sing N N 304 PHE N CA sing N N 305 PHE N H sing N N 306 PHE N H2 sing N N 307 PHE CA C sing N N 308 PHE CA CB sing N N 309 PHE CA HA sing N N 310 PHE C O doub N N 311 PHE C OXT sing N N 312 PHE CB CG sing N N 313 PHE CB HB2 sing N N 314 PHE CB HB3 sing N N 315 PHE CG CD1 doub Y N 316 PHE CG CD2 sing Y N 317 PHE CD1 CE1 sing Y N 318 PHE CD1 HD1 sing N N 319 PHE CD2 CE2 doub Y N 320 PHE CD2 HD2 sing N N 321 PHE CE1 CZ doub Y N 322 PHE CE1 HE1 sing N N 323 PHE CE2 CZ sing Y N 324 PHE CE2 HE2 sing N N 325 PHE CZ HZ sing N N 326 PHE OXT HXT sing N N 327 PRO N CA sing N N 328 PRO N CD sing N N 329 PRO N H sing N N 330 PRO CA C sing N N 331 PRO CA CB sing N N 332 PRO CA HA sing N N 333 PRO C O doub N N 334 PRO C OXT sing N N 335 PRO CB CG sing N N 336 PRO CB HB2 sing N N 337 PRO CB HB3 sing N N 338 PRO CG CD sing N N 339 PRO CG HG2 sing N N 340 PRO CG HG3 sing N N 341 PRO CD HD2 sing N N 342 PRO CD HD3 sing N N 343 PRO OXT HXT sing N N 344 SER N CA sing N N 345 SER N H sing N N 346 SER N H2 sing N N 347 SER CA C sing N N 348 SER CA CB sing N N 349 SER CA HA sing N N 350 SER C O doub N N 351 SER C OXT sing N N 352 SER CB OG sing N N 353 SER CB HB2 sing N N 354 SER CB HB3 sing N N 355 SER OG HG sing N N 356 SER OXT HXT sing N N 357 THR N CA sing N N 358 THR N H sing N N 359 THR N H2 sing N N 360 THR CA C sing N N 361 THR CA CB sing N N 362 THR CA HA sing N N 363 THR C O doub N N 364 THR C OXT sing N N 365 THR CB OG1 sing N N 366 THR CB CG2 sing N N 367 THR CB HB sing N N 368 THR OG1 HG1 sing N N 369 THR CG2 HG21 sing N N 370 THR CG2 HG22 sing N N 371 THR CG2 HG23 sing N N 372 THR OXT HXT sing N N 373 TRP N CA sing N N 374 TRP N H sing N N 375 TRP N H2 sing N N 376 TRP CA C sing N N 377 TRP CA CB sing N N 378 TRP CA HA sing N N 379 TRP C O doub N N 380 TRP C OXT sing N N 381 TRP CB CG sing N N 382 TRP CB HB2 sing N N 383 TRP CB HB3 sing N N 384 TRP CG CD1 doub Y N 385 TRP CG CD2 sing Y N 386 TRP CD1 NE1 sing Y N 387 TRP CD1 HD1 sing N N 388 TRP CD2 CE2 doub Y N 389 TRP CD2 CE3 sing Y N 390 TRP NE1 CE2 sing Y N 391 TRP NE1 HE1 sing N N 392 TRP CE2 CZ2 sing Y N 393 TRP CE3 CZ3 doub Y N 394 TRP CE3 HE3 sing N N 395 TRP CZ2 CH2 doub Y N 396 TRP CZ2 HZ2 sing N N 397 TRP CZ3 CH2 sing Y N 398 TRP CZ3 HZ3 sing N N 399 TRP CH2 HH2 sing N N 400 TRP OXT HXT sing N N 401 TYR N CA sing N N 402 TYR N H sing N N 403 TYR N H2 sing N N 404 TYR CA C sing N N 405 TYR CA CB sing N N 406 TYR CA HA sing N N 407 TYR C O doub N N 408 TYR C OXT sing N N 409 TYR CB CG sing N N 410 TYR CB HB2 sing N N 411 TYR CB HB3 sing N N 412 TYR CG CD1 doub Y N 413 TYR CG CD2 sing Y N 414 TYR CD1 CE1 sing Y N 415 TYR CD1 HD1 sing N N 416 TYR CD2 CE2 doub Y N 417 TYR CD2 HD2 sing N N 418 TYR CE1 CZ doub Y N 419 TYR CE1 HE1 sing N N 420 TYR CE2 CZ sing Y N 421 TYR CE2 HE2 sing N N 422 TYR CZ OH sing N N 423 TYR OH HH sing N N 424 TYR OXT HXT sing N N 425 VAL N CA sing N N 426 VAL N H sing N N 427 VAL N H2 sing N N 428 VAL CA C sing N N 429 VAL CA CB sing N N 430 VAL CA HA sing N N 431 VAL C O doub N N 432 VAL C OXT sing N N 433 VAL CB CG1 sing N N 434 VAL CB CG2 sing N N 435 VAL CB HB sing N N 436 VAL CG1 HG11 sing N N 437 VAL CG1 HG12 sing N N 438 VAL CG1 HG13 sing N N 439 VAL CG2 HG21 sing N N 440 VAL CG2 HG22 sing N N 441 VAL CG2 HG23 sing N N 442 VAL OXT HXT sing N N 443 # _atom_sites.entry_id 4MIA _atom_sites.fract_transf_matrix[1][1] 0.011767 _atom_sites.fract_transf_matrix[1][2] 0.000000 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 0.009541 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 0.007982 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol C N O S ZN # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . HIS A 1 1 ? 58.417 -15.178 -20.298 1.00 50.26 ? 1 HIS A N 1 ATOM 2 C CA . HIS A 1 1 ? 57.934 -14.366 -19.174 1.00 49.38 ? 1 HIS A CA 1 ATOM 3 C C . HIS A 1 1 ? 58.614 -14.812 -17.868 1.00 50.37 ? 1 HIS A C 1 ATOM 4 O O . HIS A 1 1 ? 57.942 -15.321 -16.963 1.00 49.40 ? 1 HIS A O 1 ATOM 5 C CB . HIS A 1 1 ? 56.395 -14.427 -19.042 1.00 49.85 ? 1 HIS A CB 1 ATOM 6 C CG . HIS A 1 1 ? 55.681 -14.751 -20.312 1.00 53.28 ? 1 HIS A CG 1 ATOM 7 N ND1 . HIS A 1 1 ? 55.261 -16.040 -20.595 1.00 55.12 ? 1 HIS A ND1 1 ATOM 8 C CD2 . HIS A 1 1 ? 55.353 -13.945 -21.347 1.00 55.19 ? 1 HIS A CD2 1 ATOM 9 C CE1 . HIS A 1 1 ? 54.683 -15.975 -21.783 1.00 54.66 ? 1 HIS A CE1 1 ATOM 10 N NE2 . HIS A 1 1 ? 54.716 -14.735 -22.276 1.00 55.07 ? 1 HIS A NE2 1 ATOM 11 N N . MET A 1 2 ? 59.953 -14.646 -17.790 1.00 44.76 ? 2 MET A N 1 ATOM 12 C CA . MET A 1 2 ? 60.721 -15.031 -16.600 1.00 44.00 ? 2 MET A CA 1 ATOM 13 C C . MET A 1 2 ? 60.530 -13.972 -15.526 1.00 45.55 ? 2 MET A C 1 ATOM 14 O O . MET A 1 2 ? 60.505 -12.785 -15.848 1.00 46.96 ? 2 MET A O 1 ATOM 15 C CB . MET A 1 2 ? 62.238 -15.183 -16.909 1.00 46.37 ? 2 MET A CB 1 ATOM 16 C CG . MET A 1 2 ? 62.599 -16.325 -17.880 1.00 49.98 ? 2 MET A CG 1 ATOM 17 S SD . MET A 1 2 ? 62.185 -18.010 -17.322 1.00 54.48 ? 2 MET A SD 1 ATOM 18 C CE . MET A 1 2 ? 63.238 -18.158 -15.860 1.00 51.00 ? 2 MET A CE 1 ATOM 19 N N . SER A 1 3 ? 60.417 -14.383 -14.259 1.00 38.14 ? 3 SER A N 1 ATOM 20 C CA . SER A 1 3 ? 60.297 -13.445 -13.148 1.00 36.99 ? 3 SER A CA 1 ATOM 21 C C . SER A 1 3 ? 61.533 -12.519 -13.068 1.00 42.40 ? 3 SER A C 1 ATOM 22 O O . SER A 1 3 ? 61.391 -11.321 -12.796 1.00 41.54 ? 3 SER A O 1 ATOM 23 C CB . SER A 1 3 ? 60.090 -14.190 -11.837 1.00 36.47 ? 3 SER A CB 1 ATOM 24 O OG . SER A 1 3 ? 61.074 -15.197 -11.702 1.00 37.61 ? 3 SER A OG 1 ATOM 25 N N . TYR A 1 4 ? 62.736 -13.076 -13.336 1.00 39.44 ? 4 TYR A N 1 ATOM 26 C CA . TYR A 1 4 ? 63.991 -12.333 -13.312 1.00 39.09 ? 4 TYR A CA 1 ATOM 27 C C . TYR A 1 4 ? 64.960 -12.853 -14.354 1.00 44.94 ? 4 TYR A C 1 ATOM 28 O O . TYR A 1 4 ? 65.032 -14.058 -14.556 1.00 45.98 ? 4 TYR A O 1 ATOM 29 C CB . TYR A 1 4 ? 64.683 -12.474 -11.938 1.00 39.03 ? 4 TYR A CB 1 ATOM 30 C CG . TYR A 1 4 ? 63.892 -11.967 -10.755 1.00 39.37 ? 4 TYR A CG 1 ATOM 31 C CD1 . TYR A 1 4 ? 64.019 -10.652 -10.320 1.00 40.74 ? 4 TYR A CD1 1 ATOM 32 C CD2 . TYR A 1 4 ? 63.070 -12.819 -10.025 1.00 40.04 ? 4 TYR A CD2 1 ATOM 33 C CE1 . TYR A 1 4 ? 63.305 -10.182 -9.219 1.00 41.10 ? 4 TYR A CE1 1 ATOM 34 C CE2 . TYR A 1 4 ? 62.359 -12.364 -8.917 1.00 40.84 ? 4 TYR A CE2 1 ATOM 35 C CZ . TYR A 1 4 ? 62.482 -11.044 -8.513 1.00 48.37 ? 4 TYR A CZ 1 ATOM 36 O OH . TYR A 1 4 ? 61.741 -10.575 -7.451 1.00 50.24 ? 4 TYR A OH 1 ATOM 37 N N . THR A 1 5 ? 65.736 -11.958 -14.979 1.00 41.66 ? 5 THR A N 1 ATOM 38 C CA . THR A 1 5 ? 66.863 -12.325 -15.845 1.00 42.63 ? 5 THR A CA 1 ATOM 39 C C . THR A 1 5 ? 68.091 -11.737 -15.164 1.00 47.30 ? 5 THR A C 1 ATOM 40 O O . THR A 1 5 ? 67.989 -10.649 -14.586 1.00 46.94 ? 5 THR A O 1 ATOM 41 C CB . THR A 1 5 ? 66.713 -11.949 -17.338 1.00 54.14 ? 5 THR A CB 1 ATOM 42 O OG1 . THR A 1 5 ? 66.082 -10.677 -17.491 1.00 58.43 ? 5 THR A OG1 1 ATOM 43 C CG2 . THR A 1 5 ? 65.981 -13.013 -18.135 1.00 49.53 ? 5 THR A CG2 1 ATOM 44 N N . TRP A 1 6 ? 69.211 -12.485 -15.140 1.00 44.21 ? 6 TRP A N 1 ATOM 45 C CA . TRP A 1 6 ? 70.428 -12.074 -14.432 1.00 44.06 ? 6 TRP A CA 1 ATOM 46 C C . TRP A 1 6 ? 71.658 -11.941 -15.327 1.00 51.83 ? 6 TRP A C 1 ATOM 47 O O . TRP A 1 6 ? 71.730 -12.549 -16.387 1.00 52.95 ? 6 TRP A O 1 ATOM 48 C CB . TRP A 1 6 ? 70.717 -13.013 -13.265 1.00 42.28 ? 6 TRP A CB 1 ATOM 49 C CG . TRP A 1 6 ? 69.557 -13.219 -12.351 1.00 43.43 ? 6 TRP A CG 1 ATOM 50 C CD1 . TRP A 1 6 ? 68.709 -14.285 -12.337 1.00 46.48 ? 6 TRP A CD1 1 ATOM 51 C CD2 . TRP A 1 6 ? 69.108 -12.332 -11.309 1.00 43.54 ? 6 TRP A CD2 1 ATOM 52 N NE1 . TRP A 1 6 ? 67.771 -14.130 -11.343 1.00 46.60 ? 6 TRP A NE1 1 ATOM 53 C CE2 . TRP A 1 6 ? 68.007 -12.951 -10.679 1.00 47.89 ? 6 TRP A CE2 1 ATOM 54 C CE3 . TRP A 1 6 ? 69.543 -11.076 -10.833 1.00 44.82 ? 6 TRP A CE3 1 ATOM 55 C CZ2 . TRP A 1 6 ? 67.334 -12.363 -9.593 1.00 46.98 ? 6 TRP A CZ2 1 ATOM 56 C CZ3 . TRP A 1 6 ? 68.871 -10.492 -9.767 1.00 46.21 ? 6 TRP A CZ3 1 ATOM 57 C CH2 . TRP A 1 6 ? 67.779 -11.131 -9.161 1.00 46.83 ? 6 TRP A CH2 1 ATOM 58 N N . THR A 1 7 ? 72.619 -11.135 -14.891 1.00 49.75 ? 7 THR A N 1 ATOM 59 C CA . THR A 1 7 ? 73.856 -10.866 -15.615 1.00 49.63 ? 7 THR A CA 1 ATOM 60 C C . THR A 1 7 ? 75.013 -11.710 -15.040 1.00 52.50 ? 7 THR A C 1 ATOM 61 O O . THR A 1 7 ? 75.825 -12.243 -15.794 1.00 53.18 ? 7 THR A O 1 ATOM 62 C CB . THR A 1 7 ? 74.178 -9.364 -15.552 1.00 54.30 ? 7 THR A CB 1 ATOM 63 O OG1 . THR A 1 7 ? 74.456 -9.016 -14.194 1.00 53.00 ? 7 THR A OG1 1 ATOM 64 C CG2 . THR A 1 7 ? 73.053 -8.494 -16.105 1.00 49.31 ? 7 THR A CG2 1 ATOM 65 N N . GLY A 1 8 ? 75.070 -11.810 -13.721 1.00 46.74 ? 8 GLY A N 1 ATOM 66 C CA . GLY A 1 8 ? 76.111 -12.544 -13.019 1.00 46.29 ? 8 GLY A CA 1 ATOM 67 C C . GLY A 1 8 ? 76.719 -11.717 -11.910 1.00 49.78 ? 8 GLY A C 1 ATOM 68 O O . GLY A 1 8 ? 77.474 -12.245 -11.088 1.00 49.60 ? 8 GLY A O 1 ATOM 69 N N . ALA A 1 9 ? 76.412 -10.402 -11.898 1.00 45.28 ? 9 ALA A N 1 ATOM 70 C CA . ALA A 1 9 ? 76.877 -9.472 -10.878 1.00 44.28 ? 9 ALA A CA 1 ATOM 71 C C . ALA A 1 9 ? 76.166 -9.812 -9.574 1.00 48.94 ? 9 ALA A C 1 ATOM 72 O O . ALA A 1 9 ? 74.951 -10.069 -9.563 1.00 49.04 ? 9 ALA A O 1 ATOM 73 C CB . ALA A 1 9 ? 76.587 -8.038 -11.285 1.00 44.58 ? 9 ALA A CB 1 ATOM 74 N N . LEU A 1 10 ? 76.950 -9.886 -8.488 1.00 44.15 ? 10 LEU A N 1 ATOM 75 C CA . LEU A 1 10 ? 76.459 -10.239 -7.168 1.00 42.74 ? 10 LEU A CA 1 ATOM 76 C C . LEU A 1 10 ? 75.686 -9.112 -6.526 1.00 46.00 ? 10 LEU A C 1 ATOM 77 O O . LEU A 1 10 ? 75.936 -7.940 -6.808 1.00 45.45 ? 10 LEU A O 1 ATOM 78 C CB . LEU A 1 10 ? 77.621 -10.663 -6.247 1.00 42.58 ? 10 LEU A CB 1 ATOM 79 C CG . LEU A 1 10 ? 78.458 -11.865 -6.673 1.00 47.86 ? 10 LEU A CG 1 ATOM 80 C CD1 . LEU A 1 10 ? 79.611 -12.071 -5.715 1.00 47.95 ? 10 LEU A CD1 1 ATOM 81 C CD2 . LEU A 1 10 ? 77.605 -13.141 -6.802 1.00 50.63 ? 10 LEU A CD2 1 ATOM 82 N N . ILE A 1 11 ? 74.743 -9.478 -5.648 1.00 42.55 ? 11 ILE A N 1 ATOM 83 C CA . ILE A 1 11 ? 73.974 -8.558 -4.828 1.00 41.63 ? 11 ILE A CA 1 ATOM 84 C C . ILE A 1 11 ? 74.949 -8.270 -3.670 1.00 46.78 ? 11 ILE A C 1 ATOM 85 O O . ILE A 1 11 ? 75.333 -9.190 -2.936 1.00 46.14 ? 11 ILE A O 1 ATOM 86 C CB . ILE A 1 11 ? 72.628 -9.205 -4.385 1.00 43.81 ? 11 ILE A CB 1 ATOM 87 C CG1 . ILE A 1 11 ? 71.753 -9.541 -5.609 1.00 42.91 ? 11 ILE A CG1 1 ATOM 88 C CG2 . ILE A 1 11 ? 71.877 -8.293 -3.408 1.00 45.06 ? 11 ILE A CG2 1 ATOM 89 C CD1 . ILE A 1 11 ? 70.632 -10.495 -5.371 1.00 46.52 ? 11 ILE A CD1 1 ATOM 90 N N . THR A 1 12 ? 75.422 -7.018 -3.590 1.00 44.91 ? 12 THR A N 1 ATOM 91 C CA . THR A 1 12 ? 76.424 -6.567 -2.617 1.00 45.47 ? 12 THR A CA 1 ATOM 92 C C . THR A 1 12 ? 75.821 -5.783 -1.425 1.00 53.98 ? 12 THR A C 1 ATOM 93 O O . THR A 1 12 ? 74.878 -5.024 -1.624 1.00 54.03 ? 12 THR A O 1 ATOM 94 C CB . THR A 1 12 ? 77.530 -5.759 -3.338 1.00 42.20 ? 12 THR A CB 1 ATOM 95 O OG1 . THR A 1 12 ? 76.961 -4.563 -3.856 1.00 38.98 ? 12 THR A OG1 1 ATOM 96 C CG2 . THR A 1 12 ? 78.185 -6.533 -4.473 1.00 37.11 ? 12 THR A CG2 1 ATOM 97 N N . PRO A 1 13 ? 76.372 -5.895 -0.190 1.00 53.80 ? 13 PRO A N 1 ATOM 98 C CA . PRO A 1 13 ? 75.816 -5.102 0.927 1.00 54.37 ? 13 PRO A CA 1 ATOM 99 C C . PRO A 1 13 ? 76.342 -3.660 0.945 1.00 59.79 ? 13 PRO A C 1 ATOM 100 O O . PRO A 1 13 ? 77.131 -3.279 0.079 1.00 57.72 ? 13 PRO A O 1 ATOM 101 C CB . PRO A 1 13 ? 76.284 -5.873 2.162 1.00 56.27 ? 13 PRO A CB 1 ATOM 102 C CG . PRO A 1 13 ? 77.601 -6.496 1.739 1.00 60.69 ? 13 PRO A CG 1 ATOM 103 C CD . PRO A 1 13 ? 77.515 -6.730 0.248 1.00 56.01 ? 13 PRO A CD 1 ATOM 104 N N . CYS A 1 14 ? 75.927 -2.866 1.952 1.00 59.50 ? 14 CYS A N 1 ATOM 105 C CA . CYS A 1 14 ? 76.411 -1.492 2.115 1.00 60.45 ? 14 CYS A CA 1 ATOM 106 C C . CYS A 1 14 ? 77.495 -1.461 3.183 1.00 62.45 ? 14 CYS A C 1 ATOM 107 O O . CYS A 1 14 ? 78.623 -1.048 2.910 1.00 61.57 ? 14 CYS A O 1 ATOM 108 C CB . CYS A 1 14 ? 75.267 -0.539 2.440 1.00 61.87 ? 14 CYS A CB 1 ATOM 109 S SG . CYS A 1 14 ? 73.987 -0.463 1.157 1.00 66.60 ? 14 CYS A SG 1 ATOM 110 N N . ALA A 1 15 ? 77.157 -1.957 4.383 1.00 58.47 ? 15 ALA A N 1 ATOM 111 C CA . ALA A 1 15 ? 78.047 -2.024 5.535 1.00 57.86 ? 15 ALA A CA 1 ATOM 112 C C . ALA A 1 15 ? 78.376 -3.464 5.922 1.00 61.21 ? 15 ALA A C 1 ATOM 113 O O . ALA A 1 15 ? 78.208 -4.390 5.118 1.00 59.81 ? 15 ALA A O 1 ATOM 114 C CB . ALA A 1 15 ? 77.425 -1.281 6.714 1.00 58.55 ? 15 ALA A CB 1 ATOM 115 N N . ALA A 1 16 ? 78.896 -3.631 7.154 1.00 58.74 ? 16 ALA A N 1 ATOM 116 C CA . ALA A 1 16 ? 79.288 -4.902 7.754 1.00 58.28 ? 16 ALA A CA 1 ATOM 117 C C . ALA A 1 16 ? 78.052 -5.747 7.938 1.00 60.87 ? 16 ALA A C 1 ATOM 118 O O . ALA A 1 16 ? 76.974 -5.213 8.205 1.00 61.54 ? 16 ALA A O 1 ATOM 119 C CB . ALA A 1 16 ? 79.960 -4.663 9.103 1.00 58.97 ? 16 ALA A CB 1 ATOM 120 N N . GLU A 1 17 ? 78.195 -7.052 7.755 1.00 55.22 ? 17 GLU A N 1 ATOM 121 C CA . GLU A 1 17 ? 77.092 -7.980 7.911 1.00 54.04 ? 17 GLU A CA 1 ATOM 122 C C . GLU A 1 17 ? 77.455 -8.998 8.968 1.00 57.87 ? 17 GLU A C 1 ATOM 123 O O . GLU A 1 17 ? 78.588 -9.479 8.992 1.00 57.77 ? 17 GLU A O 1 ATOM 124 C CB . GLU A 1 17 ? 76.745 -8.638 6.570 1.00 55.08 ? 17 GLU A CB 1 ATOM 125 C CG . GLU A 1 17 ? 76.058 -7.690 5.593 1.00 61.15 ? 17 GLU A CG 1 ATOM 126 C CD . GLU A 1 17 ? 75.329 -8.363 4.449 1.00 63.34 ? 17 GLU A CD 1 ATOM 127 O OE1 . GLU A 1 17 ? 76.000 -9.039 3.636 1.00 44.78 ? 17 GLU A OE1 1 ATOM 128 O OE2 . GLU A 1 17 ? 74.094 -8.187 4.342 1.00 46.85 ? 17 GLU A OE2 1 ATOM 129 N N . GLU A 1 18 ? 76.514 -9.282 9.873 1.00 54.18 ? 18 GLU A N 1 ATOM 130 C CA . GLU A 1 18 ? 76.693 -10.251 10.954 1.00 54.00 ? 18 GLU A CA 1 ATOM 131 C C . GLU A 1 18 ? 75.708 -11.419 10.801 1.00 57.67 ? 18 GLU A C 1 ATOM 132 O O . GLU A 1 18 ? 74.493 -11.210 10.797 1.00 57.54 ? 18 GLU A O 1 ATOM 133 C CB . GLU A 1 18 ? 76.497 -9.583 12.324 1.00 55.44 ? 18 GLU A CB 1 ATOM 134 C CG . GLU A 1 18 ? 77.637 -8.685 12.769 1.00 65.12 ? 18 GLU A CG 1 ATOM 135 C CD . GLU A 1 18 ? 77.462 -8.146 14.177 1.00 80.85 ? 18 GLU A CD 1 ATOM 136 O OE1 . GLU A 1 18 ? 76.459 -7.438 14.427 1.00 50.20 ? 18 GLU A OE1 1 ATOM 137 O OE2 . GLU A 1 18 ? 78.331 -8.436 15.031 1.00 77.57 ? 18 GLU A OE2 1 ATOM 138 N N . SER A 1 19 ? 76.227 -12.640 10.665 1.00 53.66 ? 19 SER A N 1 ATOM 139 C CA . SER A 1 19 ? 75.376 -13.828 10.553 1.00 53.30 ? 19 SER A CA 1 ATOM 140 C C . SER A 1 19 ? 75.171 -14.496 11.924 1.00 55.13 ? 19 SER A C 1 ATOM 141 O O . SER A 1 19 ? 74.059 -14.925 12.234 1.00 54.69 ? 19 SER A O 1 ATOM 142 C CB . SER A 1 19 ? 75.939 -14.815 9.533 1.00 58.24 ? 19 SER A CB 1 ATOM 143 O OG . SER A 1 19 ? 77.313 -15.102 9.754 1.00 69.94 ? 19 SER A OG 1 ATOM 144 N N . LYS A 1 20 ? 76.237 -14.553 12.743 1.00 49.94 ? 20 LYS A N 1 ATOM 145 C CA . LYS A 1 20 ? 76.250 -15.153 14.080 1.00 48.93 ? 20 LYS A CA 1 ATOM 146 C C . LYS A 1 20 ? 75.621 -14.213 15.116 1.00 50.35 ? 20 LYS A C 1 ATOM 147 O O . LYS A 1 20 ? 75.863 -13.001 15.066 1.00 50.07 ? 20 LYS A O 1 ATOM 148 C CB . LYS A 1 20 ? 77.694 -15.480 14.495 1.00 51.63 ? 20 LYS A CB 1 ATOM 149 C CG . LYS A 1 20 ? 78.376 -16.575 13.684 1.00 73.32 ? 20 LYS A CG 1 ATOM 150 C CD . LYS A 1 20 ? 79.915 -16.523 13.866 1.00 87.08 ? 20 LYS A CD 1 ATOM 151 C CE . LYS A 1 20 ? 80.557 -17.837 14.243 1.00 100.35 ? 20 LYS A CE 1 ATOM 152 N NZ . LYS A 1 20 ? 82.035 -17.700 14.362 1.00 105.23 ? 20 LYS A NZ 1 ATOM 153 N N . LEU A 1 21 ? 74.851 -14.781 16.073 1.00 44.82 ? 21 LEU A N 1 ATOM 154 C CA . LEU A 1 21 ? 74.178 -14.042 17.155 1.00 44.24 ? 21 LEU A CA 1 ATOM 155 C C . LEU A 1 21 ? 75.180 -13.307 18.083 1.00 49.22 ? 21 LEU A C 1 ATOM 156 O O . LEU A 1 21 ? 75.964 -13.970 18.782 1.00 49.81 ? 21 LEU A O 1 ATOM 157 C CB . LEU A 1 21 ? 73.256 -14.977 17.980 1.00 43.79 ? 21 LEU A CB 1 ATOM 158 C CG . LEU A 1 21 ? 72.567 -14.395 19.232 1.00 47.74 ? 21 LEU A CG 1 ATOM 159 C CD1 . LEU A 1 21 ? 71.505 -13.361 18.872 1.00 48.68 ? 21 LEU A CD1 1 ATOM 160 C CD2 . LEU A 1 21 ? 71.946 -15.487 20.069 1.00 47.52 ? 21 LEU A CD2 1 ATOM 161 N N . PRO A 1 22 ? 75.154 -11.945 18.113 1.00 44.09 ? 22 PRO A N 1 ATOM 162 C CA . PRO A 1 22 ? 76.085 -11.206 18.976 1.00 42.81 ? 22 PRO A CA 1 ATOM 163 C C . PRO A 1 22 ? 75.728 -11.391 20.438 1.00 45.03 ? 22 PRO A C 1 ATOM 164 O O . PRO A 1 22 ? 74.566 -11.229 20.820 1.00 45.57 ? 22 PRO A O 1 ATOM 165 C CB . PRO A 1 22 ? 75.904 -9.754 18.521 1.00 44.72 ? 22 PRO A CB 1 ATOM 166 C CG . PRO A 1 22 ? 75.210 -9.849 17.191 1.00 49.65 ? 22 PRO A CG 1 ATOM 167 C CD . PRO A 1 22 ? 74.306 -11.008 17.356 1.00 45.36 ? 22 PRO A CD 1 ATOM 168 N N . ILE A 1 23 ? 76.721 -11.796 21.236 1.00 38.85 ? 23 ILE A N 1 ATOM 169 C CA . ILE A 1 23 ? 76.568 -12.075 22.661 1.00 37.21 ? 23 ILE A CA 1 ATOM 170 C C . ILE A 1 23 ? 77.084 -10.911 23.516 1.00 42.88 ? 23 ILE A C 1 ATOM 171 O O . ILE A 1 23 ? 78.169 -10.368 23.255 1.00 43.34 ? 23 ILE A O 1 ATOM 172 C CB . ILE A 1 23 ? 77.229 -13.447 23.016 1.00 39.09 ? 23 ILE A CB 1 ATOM 173 C CG1 . ILE A 1 23 ? 76.664 -14.626 22.163 1.00 38.77 ? 23 ILE A CG1 1 ATOM 174 C CG2 . ILE A 1 23 ? 77.191 -13.770 24.506 1.00 39.11 ? 23 ILE A CG2 1 ATOM 175 C CD1 . ILE A 1 23 ? 75.152 -14.728 22.012 1.00 44.17 ? 23 ILE A CD1 1 ATOM 176 N N . ASN A 1 24 ? 76.277 -10.525 24.520 1.00 39.10 ? 24 ASN A N 1 ATOM 177 C CA . ASN A 1 24 ? 76.563 -9.493 25.509 1.00 38.50 ? 24 ASN A CA 1 ATOM 178 C C . ASN A 1 24 ? 76.249 -10.061 26.914 1.00 42.93 ? 24 ASN A C 1 ATOM 179 O O . ASN A 1 24 ? 76.072 -11.275 27.010 1.00 42.89 ? 24 ASN A O 1 ATOM 180 C CB . ASN A 1 24 ? 75.843 -8.178 25.155 1.00 35.93 ? 24 ASN A CB 1 ATOM 181 C CG . ASN A 1 24 ? 74.428 -7.991 25.637 1.00 52.97 ? 24 ASN A CG 1 ATOM 182 O OD1 . ASN A 1 24 ? 73.767 -8.908 26.139 1.00 45.04 ? 24 ASN A OD1 1 ATOM 183 N ND2 . ASN A 1 24 ? 73.940 -6.767 25.499 1.00 45.84 ? 24 ASN A ND2 1 ATOM 184 N N . ALA A 1 25 ? 76.226 -9.232 27.989 1.00 39.32 ? 25 ALA A N 1 ATOM 185 C CA . ALA A 1 25 ? 75.949 -9.710 29.362 1.00 38.62 ? 25 ALA A CA 1 ATOM 186 C C . ALA A 1 25 ? 74.495 -10.197 29.566 1.00 41.32 ? 25 ALA A C 1 ATOM 187 O O . ALA A 1 25 ? 74.257 -11.175 30.295 1.00 39.92 ? 25 ALA A O 1 ATOM 188 C CB . ALA A 1 25 ? 76.296 -8.634 30.381 1.00 39.05 ? 25 ALA A CB 1 ATOM 189 N N . LEU A 1 26 ? 73.538 -9.534 28.879 1.00 37.14 ? 26 LEU A N 1 ATOM 190 C CA . LEU A 1 26 ? 72.095 -9.805 28.960 1.00 36.20 ? 26 LEU A CA 1 ATOM 191 C C . LEU A 1 26 ? 71.628 -11.015 28.132 1.00 39.49 ? 26 LEU A C 1 ATOM 192 O O . LEU A 1 26 ? 70.500 -11.483 28.310 1.00 39.08 ? 26 LEU A O 1 ATOM 193 C CB . LEU A 1 26 ? 71.317 -8.552 28.537 1.00 35.77 ? 26 LEU A CB 1 ATOM 194 C CG . LEU A 1 26 ? 71.704 -7.255 29.210 1.00 40.48 ? 26 LEU A CG 1 ATOM 195 C CD1 . LEU A 1 26 ? 71.266 -6.053 28.391 1.00 39.81 ? 26 LEU A CD1 1 ATOM 196 C CD2 . LEU A 1 26 ? 71.173 -7.202 30.628 1.00 44.13 ? 26 LEU A CD2 1 ATOM 197 N N . SER A 1 27 ? 72.495 -11.516 27.235 1.00 35.61 ? 27 SER A N 1 ATOM 198 C CA . SER A 1 27 ? 72.190 -12.611 26.314 1.00 35.09 ? 27 SER A CA 1 ATOM 199 C C . SER A 1 27 ? 71.697 -13.876 26.998 1.00 38.38 ? 27 SER A C 1 ATOM 200 O O . SER A 1 27 ? 70.625 -14.373 26.645 1.00 36.77 ? 27 SER A O 1 ATOM 201 C CB . SER A 1 27 ? 73.386 -12.906 25.410 1.00 37.80 ? 27 SER A CB 1 ATOM 202 O OG . SER A 1 27 ? 73.782 -11.755 24.683 1.00 43.75 ? 27 SER A OG 1 ATOM 203 N N . ASN A 1 28 ? 72.468 -14.375 27.991 1.00 35.62 ? 28 ASN A N 1 ATOM 204 C CA . ASN A 1 28 ? 72.197 -15.606 28.728 1.00 35.53 ? 28 ASN A CA 1 ATOM 205 C C . ASN A 1 28 ? 70.956 -15.566 29.609 1.00 40.51 ? 28 ASN A C 1 ATOM 206 O O . ASN A 1 28 ? 70.412 -16.632 29.913 1.00 40.66 ? 28 ASN A O 1 ATOM 207 C CB . ASN A 1 28 ? 73.412 -16.032 29.530 1.00 37.77 ? 28 ASN A CB 1 ATOM 208 C CG . ASN A 1 28 ? 74.565 -16.492 28.673 1.00 60.83 ? 28 ASN A CG 1 ATOM 209 O OD1 . ASN A 1 28 ? 74.405 -16.811 27.495 1.00 53.90 ? 28 ASN A OD1 1 ATOM 210 N ND2 . ASN A 1 28 ? 75.764 -16.519 29.249 1.00 51.99 ? 28 ASN A ND2 1 ATOM 211 N N . SER A 1 29 ? 70.472 -14.362 29.990 1.00 37.46 ? 29 SER A N 1 ATOM 212 C CA . SER A 1 29 ? 69.261 -14.249 30.811 1.00 37.53 ? 29 SER A CA 1 ATOM 213 C C . SER A 1 29 ? 67.998 -14.507 29.973 1.00 41.24 ? 29 SER A C 1 ATOM 214 O O . SER A 1 29 ? 66.898 -14.610 30.517 1.00 39.86 ? 29 SER A O 1 ATOM 215 C CB . SER A 1 29 ? 69.205 -12.902 31.527 1.00 40.72 ? 29 SER A CB 1 ATOM 216 O OG . SER A 1 29 ? 69.115 -11.822 30.617 1.00 50.33 ? 29 SER A OG 1 ATOM 217 N N . LEU A 1 30 ? 68.181 -14.623 28.640 1.00 37.81 ? 30 LEU A N 1 ATOM 218 C CA . LEU A 1 30 ? 67.124 -14.871 27.664 1.00 36.66 ? 30 LEU A CA 1 ATOM 219 C C . LEU A 1 30 ? 67.375 -16.177 26.887 1.00 41.72 ? 30 LEU A C 1 ATOM 220 O O . LEU A 1 30 ? 66.500 -17.021 26.800 1.00 39.38 ? 30 LEU A O 1 ATOM 221 C CB . LEU A 1 30 ? 66.997 -13.651 26.694 1.00 35.68 ? 30 LEU A CB 1 ATOM 222 C CG . LEU A 1 30 ? 65.950 -13.723 25.544 1.00 38.79 ? 30 LEU A CG 1 ATOM 223 C CD1 . LEU A 1 30 ? 64.537 -13.918 26.065 1.00 38.12 ? 30 LEU A CD1 1 ATOM 224 C CD2 . LEU A 1 30 ? 65.994 -12.498 24.677 1.00 39.87 ? 30 LEU A CD2 1 ATOM 225 N N . LEU A 1 31 ? 68.556 -16.331 26.315 1.00 42.26 ? 31 LEU A N 1 ATOM 226 C CA . LEU A 1 31 ? 68.831 -17.459 25.440 1.00 43.92 ? 31 LEU A CA 1 ATOM 227 C C . LEU A 1 31 ? 70.167 -18.090 25.766 1.00 51.27 ? 31 LEU A C 1 ATOM 228 O O . LEU A 1 31 ? 71.155 -17.385 25.992 1.00 51.08 ? 31 LEU A O 1 ATOM 229 C CB . LEU A 1 31 ? 68.836 -16.920 23.990 1.00 43.99 ? 31 LEU A CB 1 ATOM 230 C CG . LEU A 1 31 ? 68.581 -17.889 22.867 1.00 48.38 ? 31 LEU A CG 1 ATOM 231 C CD1 . LEU A 1 31 ? 67.402 -17.450 22.035 1.00 48.01 ? 31 LEU A CD1 1 ATOM 232 C CD2 . LEU A 1 31 ? 69.776 -17.966 21.972 1.00 51.47 ? 31 LEU A CD2 1 ATOM 233 N N . ARG A 1 32 ? 70.205 -19.421 25.768 1.00 50.09 ? 32 ARG A N 1 ATOM 234 C CA . ARG A 1 32 ? 71.451 -20.135 26.024 1.00 50.81 ? 32 ARG A CA 1 ATOM 235 C C . ARG A 1 32 ? 71.984 -20.798 24.752 1.00 54.28 ? 32 ARG A C 1 ATOM 236 O O . ARG A 1 32 ? 73.181 -20.694 24.481 1.00 53.95 ? 32 ARG A O 1 ATOM 237 C CB . ARG A 1 32 ? 71.321 -21.109 27.207 1.00 52.87 ? 32 ARG A CB 1 ATOM 238 C CG . ARG A 1 32 ? 71.103 -20.406 28.552 1.00 66.34 ? 32 ARG A CG 1 ATOM 239 C CD . ARG A 1 32 ? 71.555 -21.257 29.726 1.00 86.31 ? 32 ARG A CD 1 ATOM 240 N NE . ARG A 1 32 ? 71.883 -20.440 30.900 1.00 101.26 ? 32 ARG A NE 1 ATOM 241 C CZ . ARG A 1 32 ? 73.118 -20.102 31.267 1.00 111.78 ? 32 ARG A CZ 1 ATOM 242 N NH1 . ARG A 1 32 ? 74.168 -20.520 30.565 1.00 91.99 ? 32 ARG A NH1 1 ATOM 243 N NH2 . ARG A 1 32 ? 73.314 -19.351 32.344 1.00 97.58 ? 32 ARG A NH2 1 ATOM 244 N N . HIS A 1 33 ? 71.090 -21.403 23.935 1.00 50.21 ? 33 HIS A N 1 ATOM 245 C CA . HIS A 1 33 ? 71.468 -22.070 22.683 1.00 49.75 ? 33 HIS A CA 1 ATOM 246 C C . HIS A 1 33 ? 71.624 -21.055 21.559 1.00 52.24 ? 33 HIS A C 1 ATOM 247 O O . HIS A 1 33 ? 70.760 -20.931 20.694 1.00 50.97 ? 33 HIS A O 1 ATOM 248 C CB . HIS A 1 33 ? 70.501 -23.219 22.329 1.00 50.57 ? 33 HIS A CB 1 ATOM 249 C CG . HIS A 1 33 ? 70.174 -24.118 23.483 1.00 53.82 ? 33 HIS A CG 1 ATOM 250 N ND1 . HIS A 1 33 ? 68.930 -24.700 23.603 1.00 55.60 ? 33 HIS A ND1 1 ATOM 251 C CD2 . HIS A 1 33 ? 70.935 -24.484 24.545 1.00 55.38 ? 33 HIS A CD2 1 ATOM 252 C CE1 . HIS A 1 33 ? 68.974 -25.411 24.720 1.00 55.14 ? 33 HIS A CE1 1 ATOM 253 N NE2 . HIS A 1 33 ? 70.155 -25.293 25.331 1.00 55.29 ? 33 HIS A NE2 1 ATOM 254 N N . HIS A 1 34 ? 72.733 -20.298 21.623 1.00 48.88 ? 34 HIS A N 1 ATOM 255 C CA . HIS A 1 34 ? 73.102 -19.202 20.723 1.00 48.13 ? 34 HIS A CA 1 ATOM 256 C C . HIS A 1 34 ? 73.317 -19.606 19.280 1.00 51.50 ? 34 HIS A C 1 ATOM 257 O O . HIS A 1 34 ? 73.040 -18.812 18.384 1.00 50.92 ? 34 HIS A O 1 ATOM 258 C CB . HIS A 1 34 ? 74.343 -18.465 21.251 1.00 48.42 ? 34 HIS A CB 1 ATOM 259 C CG . HIS A 1 34 ? 74.200 -17.951 22.650 1.00 51.77 ? 34 HIS A CG 1 ATOM 260 N ND1 . HIS A 1 34 ? 75.275 -17.926 23.511 1.00 53.59 ? 34 HIS A ND1 1 ATOM 261 C CD2 . HIS A 1 34 ? 73.120 -17.428 23.283 1.00 53.71 ? 34 HIS A CD2 1 ATOM 262 C CE1 . HIS A 1 34 ? 74.820 -17.404 24.639 1.00 53.10 ? 34 HIS A CE1 1 ATOM 263 N NE2 . HIS A 1 34 ? 73.528 -17.092 24.551 1.00 53.37 ? 34 HIS A NE2 1 ATOM 264 N N . ASN A 1 35 ? 73.817 -20.832 19.055 1.00 47.61 ? 35 ASN A N 1 ATOM 265 C CA . ASN A 1 35 ? 74.104 -21.381 17.723 1.00 46.66 ? 35 ASN A CA 1 ATOM 266 C C . ASN A 1 35 ? 72.827 -21.626 16.911 1.00 48.36 ? 35 ASN A C 1 ATOM 267 O O . ASN A 1 35 ? 72.896 -21.773 15.687 1.00 49.17 ? 35 ASN A O 1 ATOM 268 C CB . ASN A 1 35 ? 74.956 -22.653 17.834 1.00 48.28 ? 35 ASN A CB 1 ATOM 269 C CG . ASN A 1 35 ? 76.139 -22.509 18.772 1.00 82.01 ? 35 ASN A CG 1 ATOM 270 O OD1 . ASN A 1 35 ? 76.969 -21.591 18.648 1.00 75.35 ? 35 ASN A OD1 1 ATOM 271 N ND2 . ASN A 1 35 ? 76.222 -23.400 19.751 1.00 76.12 ? 35 ASN A ND2 1 ATOM 272 N N A MET A 1 36 ? 71.669 -21.658 17.594 0.50 43.30 ? 36 MET A N 1 ATOM 273 N N B MET A 1 36 ? 71.674 -21.658 17.586 0.50 43.46 ? 36 MET A N 1 ATOM 274 C CA A MET A 1 36 ? 70.351 -21.847 16.994 0.50 42.55 ? 36 MET A CA 1 ATOM 275 C CA B MET A 1 36 ? 70.374 -21.859 16.960 0.50 42.79 ? 36 MET A CA 1 ATOM 276 C C A MET A 1 36 ? 69.915 -20.597 16.232 0.50 45.43 ? 36 MET A C 1 ATOM 277 C C B MET A 1 36 ? 69.906 -20.597 16.232 0.50 45.53 ? 36 MET A C 1 ATOM 278 O O A MET A 1 36 ? 69.255 -20.710 15.200 0.50 45.54 ? 36 MET A O 1 ATOM 279 O O B MET A 1 36 ? 69.233 -20.702 15.208 0.50 45.62 ? 36 MET A O 1 ATOM 280 C CB A MET A 1 36 ? 69.306 -22.166 18.078 0.50 44.88 ? 36 MET A CB 1 ATOM 281 C CB B MET A 1 36 ? 69.343 -22.295 18.005 0.50 45.19 ? 36 MET A CB 1 ATOM 282 C CG A MET A 1 36 ? 69.497 -23.512 18.742 0.50 48.62 ? 36 MET A CG 1 ATOM 283 C CG B MET A 1 36 ? 69.634 -23.659 18.588 0.50 49.02 ? 36 MET A CG 1 ATOM 284 S SD A MET A 1 36 ? 69.328 -24.903 17.608 0.50 53.01 ? 36 MET A SD 1 ATOM 285 S SD B MET A 1 36 ? 68.138 -24.532 19.084 0.50 53.56 ? 36 MET A SD 1 ATOM 286 C CE A MET A 1 36 ? 67.528 -24.954 17.406 0.50 49.87 ? 36 MET A CE 1 ATOM 287 C CE B MET A 1 36 ? 67.470 -24.995 17.461 0.50 50.44 ? 36 MET A CE 1 ATOM 288 N N . VAL A 1 37 ? 70.270 -19.411 16.758 1.00 40.28 ? 37 VAL A N 1 ATOM 289 C CA . VAL A 1 37 ? 69.918 -18.103 16.201 1.00 38.27 ? 37 VAL A CA 1 ATOM 290 C C . VAL A 1 37 ? 70.970 -17.610 15.216 1.00 41.86 ? 37 VAL A C 1 ATOM 291 O O . VAL A 1 37 ? 72.169 -17.621 15.515 1.00 40.77 ? 37 VAL A O 1 ATOM 292 C CB . VAL A 1 37 ? 69.623 -17.077 17.329 1.00 40.45 ? 37 VAL A CB 1 ATOM 293 C CG1 . VAL A 1 37 ? 69.416 -15.667 16.777 1.00 39.64 ? 37 VAL A CG1 1 ATOM 294 C CG2 . VAL A 1 37 ? 68.420 -17.520 18.167 1.00 40.04 ? 37 VAL A CG2 1 ATOM 295 N N . TYR A 1 38 ? 70.499 -17.169 14.036 1.00 38.53 ? 38 TYR A N 1 ATOM 296 C CA . TYR A 1 38 ? 71.319 -16.634 12.948 1.00 37.61 ? 38 TYR A CA 1 ATOM 297 C C . TYR A 1 38 ? 70.588 -15.470 12.275 1.00 44.40 ? 38 TYR A C 1 ATOM 298 O O . TYR A 1 38 ? 69.356 -15.366 12.392 1.00 45.97 ? 38 TYR A O 1 ATOM 299 C CB . TYR A 1 38 ? 71.618 -17.741 11.913 1.00 36.66 ? 38 TYR A CB 1 ATOM 300 C CG . TYR A 1 38 ? 70.427 -18.157 11.074 1.00 35.90 ? 38 TYR A CG 1 ATOM 301 C CD1 . TYR A 1 38 ? 70.134 -17.514 9.870 1.00 36.96 ? 38 TYR A CD1 1 ATOM 302 C CD2 . TYR A 1 38 ? 69.604 -19.204 11.470 1.00 36.37 ? 38 TYR A CD2 1 ATOM 303 C CE1 . TYR A 1 38 ? 69.042 -17.896 9.090 1.00 36.37 ? 38 TYR A CE1 1 ATOM 304 C CE2 . TYR A 1 38 ? 68.503 -19.588 10.705 1.00 37.13 ? 38 TYR A CE2 1 ATOM 305 C CZ . TYR A 1 38 ? 68.240 -18.945 9.506 1.00 43.86 ? 38 TYR A CZ 1 ATOM 306 O OH . TYR A 1 38 ? 67.172 -19.332 8.744 1.00 46.09 ? 38 TYR A OH 1 ATOM 307 N N . ALA A 1 39 ? 71.337 -14.645 11.520 1.00 39.72 ? 39 ALA A N 1 ATOM 308 C CA . ALA A 1 39 ? 70.794 -13.555 10.713 1.00 39.09 ? 39 ALA A CA 1 ATOM 309 C C . ALA A 1 39 ? 71.231 -13.756 9.263 1.00 42.00 ? 39 ALA A C 1 ATOM 310 O O . ALA A 1 39 ? 72.351 -14.224 9.029 1.00 42.00 ? 39 ALA A O 1 ATOM 311 C CB . ALA A 1 39 ? 71.271 -12.210 11.222 1.00 39.79 ? 39 ALA A CB 1 ATOM 312 N N . THR A 1 40 ? 70.352 -13.431 8.294 1.00 37.15 ? 40 THR A N 1 ATOM 313 C CA . THR A 1 40 ? 70.653 -13.604 6.873 1.00 36.99 ? 40 THR A CA 1 ATOM 314 C C . THR A 1 40 ? 71.465 -12.424 6.318 1.00 42.68 ? 40 THR A C 1 ATOM 315 O O . THR A 1 40 ? 71.340 -11.296 6.811 1.00 42.02 ? 40 THR A O 1 ATOM 316 C CB . THR A 1 40 ? 69.395 -13.894 6.076 1.00 44.65 ? 40 THR A CB 1 ATOM 317 O OG1 . THR A 1 40 ? 68.477 -12.805 6.207 1.00 47.15 ? 40 THR A OG1 1 ATOM 318 C CG2 . THR A 1 40 ? 68.737 -15.184 6.493 1.00 45.00 ? 40 THR A CG2 1 ATOM 319 N N . THR A 1 41 ? 72.288 -12.681 5.282 1.00 39.30 ? 41 THR A N 1 ATOM 320 C CA . THR A 1 41 ? 73.165 -11.689 4.656 1.00 38.94 ? 41 THR A CA 1 ATOM 321 C C . THR A 1 41 ? 73.214 -11.916 3.127 1.00 45.60 ? 41 THR A C 1 ATOM 322 O O . THR A 1 41 ? 72.754 -12.957 2.637 1.00 45.18 ? 41 THR A O 1 ATOM 323 C CB . THR A 1 41 ? 74.608 -11.771 5.274 1.00 40.20 ? 41 THR A CB 1 ATOM 324 O OG1 . THR A 1 41 ? 75.257 -13.007 4.926 1.00 40.35 ? 41 THR A OG1 1 ATOM 325 C CG2 . THR A 1 41 ? 74.647 -11.561 6.781 1.00 32.40 ? 41 THR A CG2 1 ATOM 326 N N . SER A 1 42 ? 73.874 -10.980 2.394 1.00 43.62 ? 42 SER A N 1 ATOM 327 C CA . SER A 1 42 ? 74.111 -10.991 0.938 1.00 43.31 ? 42 SER A CA 1 ATOM 328 C C . SER A 1 42 ? 74.895 -12.218 0.462 1.00 49.72 ? 42 SER A C 1 ATOM 329 O O . SER A 1 42 ? 75.072 -12.405 -0.745 1.00 50.94 ? 42 SER A O 1 ATOM 330 C CB . SER A 1 42 ? 74.846 -9.723 0.518 1.00 44.74 ? 42 SER A CB 1 ATOM 331 O OG . SER A 1 42 ? 76.165 -9.717 1.042 1.00 47.44 ? 42 SER A OG 1 ATOM 332 N N . ARG A 1 43 ? 75.394 -13.021 1.415 1.00 46.36 ? 43 ARG A N 1 ATOM 333 C CA . ARG A 1 43 ? 76.171 -14.238 1.201 1.00 45.74 ? 43 ARG A CA 1 ATOM 334 C C . ARG A 1 43 ? 75.243 -15.317 0.645 1.00 47.97 ? 43 ARG A C 1 ATOM 335 O O . ARG A 1 43 ? 75.645 -16.082 -0.232 1.00 47.55 ? 43 ARG A O 1 ATOM 336 C CB . ARG A 1 43 ? 76.772 -14.684 2.552 1.00 47.12 ? 43 ARG A CB 1 ATOM 337 C CG . ARG A 1 43 ? 78.024 -15.547 2.457 1.00 57.57 ? 43 ARG A CG 1 ATOM 338 C CD . ARG A 1 43 ? 78.569 -15.920 3.825 1.00 69.79 ? 43 ARG A CD 1 ATOM 339 N NE . ARG A 1 43 ? 77.764 -16.951 4.486 1.00 78.36 ? 43 ARG A NE 1 ATOM 340 C CZ . ARG A 1 43 ? 78.045 -17.497 5.667 1.00 90.93 ? 43 ARG A CZ 1 ATOM 341 N NH1 . ARG A 1 43 ? 79.132 -17.132 6.335 1.00 77.66 ? 43 ARG A NH1 1 ATOM 342 N NH2 . ARG A 1 43 ? 77.254 -18.431 6.176 1.00 78.93 ? 43 ARG A NH2 1 ATOM 343 N N . SER A 1 44 ? 73.992 -15.361 1.141 1.00 44.12 ? 44 SER A N 1 ATOM 344 C CA . SER A 1 44 ? 73.007 -16.358 0.720 1.00 44.00 ? 44 SER A CA 1 ATOM 345 C C . SER A 1 44 ? 72.119 -15.891 -0.451 1.00 48.99 ? 44 SER A C 1 ATOM 346 O O . SER A 1 44 ? 71.263 -16.664 -0.912 1.00 49.11 ? 44 SER A O 1 ATOM 347 C CB . SER A 1 44 ? 72.172 -16.828 1.908 1.00 46.03 ? 44 SER A CB 1 ATOM 348 O OG . SER A 1 44 ? 71.492 -15.750 2.523 1.00 53.40 ? 44 SER A OG 1 ATOM 349 N N . ALA A 1 45 ? 72.366 -14.653 -0.964 1.00 44.44 ? 45 ALA A N 1 ATOM 350 C CA . ALA A 1 45 ? 71.603 -14.025 -2.049 1.00 43.75 ? 45 ALA A CA 1 ATOM 351 C C . ALA A 1 45 ? 71.470 -14.867 -3.304 1.00 47.68 ? 45 ALA A C 1 ATOM 352 O O . ALA A 1 45 ? 70.378 -14.928 -3.865 1.00 47.39 ? 45 ALA A O 1 ATOM 353 C CB . ALA A 1 45 ? 72.175 -12.664 -2.387 1.00 44.43 ? 45 ALA A CB 1 ATOM 354 N N . GLY A 1 46 ? 72.562 -15.521 -3.706 1.00 44.68 ? 46 GLY A N 1 ATOM 355 C CA . GLY A 1 46 ? 72.641 -16.373 -4.889 1.00 44.80 ? 46 GLY A CA 1 ATOM 356 C C . GLY A 1 46 ? 71.598 -17.468 -4.917 1.00 50.41 ? 46 GLY A C 1 ATOM 357 O O . GLY A 1 46 ? 70.967 -17.700 -5.953 1.00 50.77 ? 46 GLY A O 1 ATOM 358 N N . LEU A 1 47 ? 71.383 -18.124 -3.753 1.00 47.16 ? 47 LEU A N 1 ATOM 359 C CA . LEU A 1 47 ? 70.380 -19.174 -3.581 1.00 45.55 ? 47 LEU A CA 1 ATOM 360 C C . LEU A 1 47 ? 68.983 -18.575 -3.753 1.00 48.86 ? 47 LEU A C 1 ATOM 361 O O . LEU A 1 47 ? 68.148 -19.161 -4.450 1.00 48.99 ? 47 LEU A O 1 ATOM 362 C CB . LEU A 1 47 ? 70.519 -19.867 -2.214 1.00 44.51 ? 47 LEU A CB 1 ATOM 363 C CG . LEU A 1 47 ? 69.574 -21.043 -1.955 1.00 48.29 ? 47 LEU A CG 1 ATOM 364 C CD1 . LEU A 1 47 ? 69.645 -22.122 -3.068 1.00 48.11 ? 47 LEU A CD1 1 ATOM 365 C CD2 . LEU A 1 47 ? 69.815 -21.637 -0.602 1.00 49.79 ? 47 LEU A CD2 1 ATOM 366 N N . ARG A 1 48 ? 68.754 -17.388 -3.160 1.00 43.64 ? 48 ARG A N 1 ATOM 367 C CA . ARG A 1 48 ? 67.473 -16.713 -3.278 1.00 42.67 ? 48 ARG A CA 1 ATOM 368 C C . ARG A 1 48 ? 67.162 -16.427 -4.749 1.00 45.30 ? 48 ARG A C 1 ATOM 369 O O . ARG A 1 48 ? 66.062 -16.744 -5.195 1.00 43.97 ? 48 ARG A O 1 ATOM 370 C CB . ARG A 1 48 ? 67.445 -15.434 -2.428 1.00 41.71 ? 48 ARG A CB 1 ATOM 371 C CG . ARG A 1 48 ? 66.106 -14.680 -2.455 1.00 50.04 ? 48 ARG A CG 1 ATOM 372 C CD . ARG A 1 48 ? 64.891 -15.500 -2.020 1.00 51.58 ? 48 ARG A CD 1 ATOM 373 N NE . ARG A 1 48 ? 64.942 -15.920 -0.620 1.00 50.25 ? 48 ARG A NE 1 ATOM 374 C CZ . ARG A 1 48 ? 64.050 -16.727 -0.058 1.00 58.39 ? 48 ARG A CZ 1 ATOM 375 N NH1 . ARG A 1 48 ? 63.038 -17.205 -0.770 1.00 47.08 ? 48 ARG A NH1 1 ATOM 376 N NH2 . ARG A 1 48 ? 64.167 -17.069 1.221 1.00 38.26 ? 48 ARG A NH2 1 ATOM 377 N N . GLN A 1 49 ? 68.164 -15.895 -5.504 1.00 41.69 ? 49 GLN A N 1 ATOM 378 C CA . GLN A 1 49 ? 68.090 -15.579 -6.940 1.00 40.89 ? 49 GLN A CA 1 ATOM 379 C C . GLN A 1 49 ? 67.633 -16.781 -7.730 1.00 44.85 ? 49 GLN A C 1 ATOM 380 O O . GLN A 1 49 ? 66.771 -16.639 -8.586 1.00 44.26 ? 49 GLN A O 1 ATOM 381 C CB . GLN A 1 49 ? 69.444 -15.127 -7.490 1.00 41.79 ? 49 GLN A CB 1 ATOM 382 C CG . GLN A 1 49 ? 69.917 -13.792 -6.964 1.00 52.17 ? 49 GLN A CG 1 ATOM 383 C CD . GLN A 1 49 ? 71.269 -13.441 -7.534 1.00 72.22 ? 49 GLN A CD 1 ATOM 384 O OE1 . GLN A 1 49 ? 72.290 -14.073 -7.234 1.00 67.09 ? 49 GLN A OE1 1 ATOM 385 N NE2 . GLN A 1 49 ? 71.306 -12.421 -8.377 1.00 63.86 ? 49 GLN A NE2 1 ATOM 386 N N . LYS A 1 50 ? 68.199 -17.961 -7.442 1.00 42.19 ? 50 LYS A N 1 ATOM 387 C CA . LYS A 1 50 ? 67.829 -19.205 -8.110 1.00 42.87 ? 50 LYS A CA 1 ATOM 388 C C . LYS A 1 50 ? 66.336 -19.493 -7.868 1.00 48.43 ? 50 LYS A C 1 ATOM 389 O O . LYS A 1 50 ? 65.569 -19.593 -8.835 1.00 49.13 ? 50 LYS A O 1 ATOM 390 C CB . LYS A 1 50 ? 68.706 -20.367 -7.612 1.00 45.83 ? 50 LYS A CB 1 ATOM 391 C CG . LYS A 1 50 ? 70.176 -20.229 -7.977 1.00 65.45 ? 50 LYS A CG 1 ATOM 392 C CD . LYS A 1 50 ? 71.074 -20.908 -6.948 1.00 78.23 ? 50 LYS A CD 1 ATOM 393 C CE . LYS A 1 50 ? 72.531 -20.901 -7.348 1.00 91.88 ? 50 LYS A CE 1 ATOM 394 N NZ . LYS A 1 50 ? 73.182 -19.585 -7.100 1.00 101.70 ? 50 LYS A NZ 1 ATOM 395 N N . LYS A 1 51 ? 65.930 -19.535 -6.572 1.00 44.29 ? 51 LYS A N 1 ATOM 396 C CA . LYS A 1 51 ? 64.569 -19.790 -6.082 1.00 43.55 ? 51 LYS A CA 1 ATOM 397 C C . LYS A 1 51 ? 63.498 -18.872 -6.694 1.00 45.32 ? 51 LYS A C 1 ATOM 398 O O . LYS A 1 51 ? 62.467 -19.356 -7.164 1.00 44.57 ? 51 LYS A O 1 ATOM 399 C CB . LYS A 1 51 ? 64.517 -19.696 -4.538 1.00 46.22 ? 51 LYS A CB 1 ATOM 400 C CG . LYS A 1 51 ? 65.331 -20.763 -3.812 1.00 62.27 ? 51 LYS A CG 1 ATOM 401 C CD . LYS A 1 51 ? 65.128 -20.721 -2.295 1.00 72.13 ? 51 LYS A CD 1 ATOM 402 C CE . LYS A 1 51 ? 65.858 -21.837 -1.580 1.00 83.17 ? 51 LYS A CE 1 ATOM 403 N NZ . LYS A 1 51 ? 65.370 -23.196 -1.965 1.00 94.63 ? 51 LYS A NZ 1 ATOM 404 N N . VAL A 1 52 ? 63.750 -17.550 -6.682 1.00 41.07 ? 52 VAL A N 1 ATOM 405 C CA . VAL A 1 52 ? 62.798 -16.540 -7.163 1.00 40.22 ? 52 VAL A CA 1 ATOM 406 C C . VAL A 1 52 ? 62.700 -16.466 -8.690 1.00 43.79 ? 52 VAL A C 1 ATOM 407 O O . VAL A 1 52 ? 61.787 -15.799 -9.183 1.00 42.98 ? 52 VAL A O 1 ATOM 408 C CB . VAL A 1 52 ? 63.013 -15.131 -6.548 1.00 43.27 ? 52 VAL A CB 1 ATOM 409 C CG1 . VAL A 1 52 ? 62.772 -15.145 -5.050 1.00 42.59 ? 52 VAL A CG1 1 ATOM 410 C CG2 . VAL A 1 52 ? 64.375 -14.530 -6.897 1.00 42.97 ? 52 VAL A CG2 1 ATOM 411 N N . THR A 1 53 ? 63.616 -17.151 -9.425 1.00 40.57 ? 53 THR A N 1 ATOM 412 C CA . THR A 1 53 ? 63.667 -17.162 -10.894 1.00 39.70 ? 53 THR A CA 1 ATOM 413 C C . THR A 1 53 ? 62.953 -18.360 -11.498 1.00 41.66 ? 53 THR A C 1 ATOM 414 O O . THR A 1 53 ? 63.422 -19.490 -11.396 1.00 40.81 ? 53 THR A O 1 ATOM 415 C CB . THR A 1 53 ? 65.110 -17.028 -11.397 1.00 47.40 ? 53 THR A CB 1 ATOM 416 O OG1 . THR A 1 53 ? 65.667 -15.825 -10.868 1.00 46.10 ? 53 THR A OG1 1 ATOM 417 C CG2 . THR A 1 53 ? 65.198 -16.996 -12.910 1.00 45.80 ? 53 THR A CG2 1 ATOM 418 N N . PHE A 1 54 ? 61.824 -18.089 -12.147 1.00 38.70 ? 54 PHE A N 1 ATOM 419 C CA . PHE A 1 54 ? 61.005 -19.072 -12.858 1.00 39.18 ? 54 PHE A CA 1 ATOM 420 C C . PHE A 1 54 ? 60.122 -18.402 -13.905 1.00 42.66 ? 54 PHE A C 1 ATOM 421 O O . PHE A 1 54 ? 59.890 -17.192 -13.844 1.00 41.79 ? 54 PHE A O 1 ATOM 422 C CB . PHE A 1 54 ? 60.176 -19.951 -11.906 1.00 41.28 ? 54 PHE A CB 1 ATOM 423 C CG . PHE A 1 54 ? 59.329 -19.228 -10.892 1.00 42.96 ? 54 PHE A CG 1 ATOM 424 C CD1 . PHE A 1 54 ? 58.025 -18.852 -11.193 1.00 46.19 ? 54 PHE A CD1 1 ATOM 425 C CD2 . PHE A 1 54 ? 59.813 -18.977 -9.613 1.00 45.45 ? 54 PHE A CD2 1 ATOM 426 C CE1 . PHE A 1 54 ? 57.229 -18.214 -10.237 1.00 47.44 ? 54 PHE A CE1 1 ATOM 427 C CE2 . PHE A 1 54 ? 59.021 -18.334 -8.660 1.00 48.47 ? 54 PHE A CE2 1 ATOM 428 C CZ . PHE A 1 54 ? 57.734 -17.959 -8.977 1.00 46.68 ? 54 PHE A CZ 1 ATOM 429 N N . ASP A 1 55 ? 59.679 -19.185 -14.890 1.00 39.43 ? 55 ASP A N 1 ATOM 430 C CA . ASP A 1 55 ? 58.814 -18.720 -15.977 1.00 39.11 ? 55 ASP A CA 1 ATOM 431 C C . ASP A 1 55 ? 57.362 -18.802 -15.493 1.00 41.69 ? 55 ASP A C 1 ATOM 432 O O . ASP A 1 55 ? 56.999 -19.771 -14.819 1.00 40.72 ? 55 ASP A O 1 ATOM 433 C CB . ASP A 1 55 ? 59.056 -19.577 -17.243 1.00 40.75 ? 55 ASP A CB 1 ATOM 434 C CG . ASP A 1 55 ? 58.368 -19.106 -18.507 1.00 49.64 ? 55 ASP A CG 1 ATOM 435 O OD1 . ASP A 1 55 ? 58.661 -17.975 -18.961 1.00 49.21 ? 55 ASP A OD1 1 ATOM 436 O OD2 . ASP A 1 55 ? 57.597 -19.898 -19.088 1.00 57.80 ? 55 ASP A OD2 1 ATOM 437 N N . ARG A 1 56 ? 56.552 -17.771 -15.793 1.00 38.32 ? 56 ARG A N 1 ATOM 438 C CA . ARG A 1 56 ? 55.152 -17.727 -15.368 1.00 39.00 ? 56 ARG A CA 1 ATOM 439 C C . ARG A 1 56 ? 54.175 -17.929 -16.526 1.00 45.56 ? 56 ARG A C 1 ATOM 440 O O . ARG A 1 56 ? 54.224 -17.208 -17.530 1.00 44.17 ? 56 ARG A O 1 ATOM 441 C CB . ARG A 1 56 ? 54.812 -16.434 -14.585 1.00 38.47 ? 56 ARG A CB 1 ATOM 442 C CG . ARG A 1 56 ? 55.409 -16.330 -13.167 1.00 40.96 ? 56 ARG A CG 1 ATOM 443 C CD . ARG A 1 56 ? 56.834 -15.755 -13.106 1.00 36.37 ? 56 ARG A CD 1 ATOM 444 N NE . ARG A 1 56 ? 57.117 -14.771 -14.158 1.00 40.35 ? 56 ARG A NE 1 ATOM 445 C CZ . ARG A 1 56 ? 56.829 -13.469 -14.094 1.00 55.37 ? 56 ARG A CZ 1 ATOM 446 N NH1 . ARG A 1 56 ? 56.265 -12.955 -13.005 1.00 41.82 ? 56 ARG A NH1 1 ATOM 447 N NH2 . ARG A 1 56 ? 57.121 -12.669 -15.111 1.00 36.63 ? 56 ARG A NH2 1 ATOM 448 N N . LEU A 1 57 ? 53.271 -18.913 -16.366 1.00 44.63 ? 57 LEU A N 1 ATOM 449 C CA . LEU A 1 57 ? 52.248 -19.226 -17.359 1.00 45.13 ? 57 LEU A CA 1 ATOM 450 C C . LEU A 1 57 ? 50.872 -18.960 -16.766 1.00 48.78 ? 57 LEU A C 1 ATOM 451 O O . LEU A 1 57 ? 50.526 -19.535 -15.732 1.00 50.03 ? 57 LEU A O 1 ATOM 452 C CB . LEU A 1 57 ? 52.397 -20.663 -17.926 1.00 45.79 ? 57 LEU A CB 1 ATOM 453 C CG . LEU A 1 57 ? 53.677 -21.007 -18.772 1.00 51.14 ? 57 LEU A CG 1 ATOM 454 C CD1 . LEU A 1 57 ? 54.146 -19.827 -19.665 1.00 51.33 ? 57 LEU A CD1 1 ATOM 455 C CD2 . LEU A 1 57 ? 54.825 -21.538 -17.891 1.00 53.64 ? 57 LEU A CD2 1 ATOM 456 N N . GLN A 1 58 ? 50.120 -18.028 -17.392 1.00 43.57 ? 58 GLN A N 1 ATOM 457 C CA . GLN A 1 58 ? 48.804 -17.573 -16.940 1.00 42.51 ? 58 GLN A CA 1 ATOM 458 C C . GLN A 1 58 ? 47.657 -17.951 -17.869 1.00 44.93 ? 58 GLN A C 1 ATOM 459 O O . GLN A 1 58 ? 47.771 -17.851 -19.096 1.00 45.80 ? 58 GLN A O 1 ATOM 460 C CB . GLN A 1 58 ? 48.823 -16.061 -16.710 1.00 43.61 ? 58 GLN A CB 1 ATOM 461 C CG . GLN A 1 58 ? 48.242 -15.659 -15.363 1.00 51.99 ? 58 GLN A CG 1 ATOM 462 C CD . GLN A 1 58 ? 48.516 -14.212 -15.007 1.00 54.76 ? 58 GLN A CD 1 ATOM 463 O OE1 . GLN A 1 58 ? 48.986 -13.400 -15.831 1.00 45.92 ? 58 GLN A OE1 1 ATOM 464 N NE2 . GLN A 1 58 ? 48.225 -13.861 -13.758 1.00 33.56 ? 58 GLN A NE2 1 ATOM 465 N N . VAL A 1 59 ? 46.550 -18.403 -17.273 1.00 38.82 ? 59 VAL A N 1 ATOM 466 C CA . VAL A 1 59 ? 45.333 -18.821 -17.973 1.00 37.30 ? 59 VAL A CA 1 ATOM 467 C C . VAL A 1 59 ? 44.146 -18.147 -17.240 1.00 40.86 ? 59 VAL A C 1 ATOM 468 O O . VAL A 1 59 ? 43.709 -18.600 -16.173 1.00 42.12 ? 59 VAL A O 1 ATOM 469 C CB . VAL A 1 59 ? 45.223 -20.375 -18.081 1.00 40.20 ? 59 VAL A CB 1 ATOM 470 C CG1 . VAL A 1 59 ? 43.876 -20.799 -18.621 1.00 40.07 ? 59 VAL A CG1 1 ATOM 471 C CG2 . VAL A 1 59 ? 46.333 -20.963 -18.948 1.00 39.73 ? 59 VAL A CG2 1 ATOM 472 N N . LEU A 1 60 ? 43.689 -17.014 -17.787 1.00 35.25 ? 60 LEU A N 1 ATOM 473 C CA . LEU A 1 60 ? 42.625 -16.213 -17.203 1.00 34.15 ? 60 LEU A CA 1 ATOM 474 C C . LEU A 1 60 ? 41.263 -16.583 -17.799 1.00 39.04 ? 60 LEU A C 1 ATOM 475 O O . LEU A 1 60 ? 41.059 -16.474 -19.014 1.00 38.76 ? 60 LEU A O 1 ATOM 476 C CB . LEU A 1 60 ? 42.923 -14.705 -17.357 1.00 33.50 ? 60 LEU A CB 1 ATOM 477 C CG . LEU A 1 60 ? 44.292 -14.190 -16.910 1.00 36.97 ? 60 LEU A CG 1 ATOM 478 C CD1 . LEU A 1 60 ? 44.443 -12.733 -17.231 1.00 36.11 ? 60 LEU A CD1 1 ATOM 479 C CD2 . LEU A 1 60 ? 44.523 -14.407 -15.408 1.00 39.85 ? 60 LEU A CD2 1 ATOM 480 N N . ASP A 1 61 ? 40.345 -17.041 -16.931 1.00 34.89 ? 61 ASP A N 1 ATOM 481 C CA . ASP A 1 61 ? 39.007 -17.484 -17.296 1.00 35.16 ? 61 ASP A CA 1 ATOM 482 C C . ASP A 1 61 ? 37.925 -16.453 -16.909 1.00 41.17 ? 61 ASP A C 1 ATOM 483 O O . ASP A 1 61 ? 38.253 -15.397 -16.362 1.00 42.14 ? 61 ASP A O 1 ATOM 484 C CB . ASP A 1 61 ? 38.732 -18.846 -16.641 1.00 37.15 ? 61 ASP A CB 1 ATOM 485 C CG . ASP A 1 61 ? 38.473 -18.787 -15.149 1.00 48.40 ? 61 ASP A CG 1 ATOM 486 O OD1 . ASP A 1 61 ? 39.063 -17.914 -14.475 1.00 49.43 ? 61 ASP A OD1 1 ATOM 487 O OD2 . ASP A 1 61 ? 37.670 -19.595 -14.663 1.00 56.56 ? 61 ASP A OD2 1 ATOM 488 N N . ASP A 1 62 ? 36.638 -16.768 -17.188 1.00 36.07 ? 62 ASP A N 1 ATOM 489 C CA . ASP A 1 62 ? 35.513 -15.882 -16.925 1.00 34.75 ? 62 ASP A CA 1 ATOM 490 C C . ASP A 1 62 ? 35.338 -15.506 -15.451 1.00 36.06 ? 62 ASP A C 1 ATOM 491 O O . ASP A 1 62 ? 35.052 -14.339 -15.195 1.00 36.49 ? 62 ASP A O 1 ATOM 492 C CB . ASP A 1 62 ? 34.220 -16.441 -17.519 1.00 36.79 ? 62 ASP A CB 1 ATOM 493 C CG . ASP A 1 62 ? 34.189 -16.483 -19.044 1.00 44.20 ? 62 ASP A CG 1 ATOM 494 O OD1 . ASP A 1 62 ? 34.936 -15.704 -19.679 1.00 43.67 ? 62 ASP A OD1 1 ATOM 495 O OD2 . ASP A 1 62 ? 33.369 -17.245 -19.599 1.00 51.46 ? 62 ASP A OD2 1 ATOM 496 N N . HIS A 1 63 ? 35.574 -16.436 -14.490 1.00 29.75 ? 63 HIS A N 1 ATOM 497 C CA . HIS A 1 63 ? 35.466 -16.130 -13.045 1.00 28.77 ? 63 HIS A CA 1 ATOM 498 C C . HIS A 1 63 ? 36.380 -14.987 -12.661 1.00 35.05 ? 63 HIS A C 1 ATOM 499 O O . HIS A 1 63 ? 35.973 -14.125 -11.886 1.00 35.17 ? 63 HIS A O 1 ATOM 500 C CB . HIS A 1 63 ? 35.805 -17.341 -12.172 1.00 28.92 ? 63 HIS A CB 1 ATOM 501 C CG . HIS A 1 63 ? 34.773 -18.426 -12.187 1.00 32.17 ? 63 HIS A CG 1 ATOM 502 N ND1 . HIS A 1 63 ? 33.452 -18.177 -11.850 1.00 33.57 ? 63 HIS A ND1 1 ATOM 503 C CD2 . HIS A 1 63 ? 34.918 -19.748 -12.437 1.00 33.66 ? 63 HIS A CD2 1 ATOM 504 C CE1 . HIS A 1 63 ? 32.843 -19.339 -11.929 1.00 32.83 ? 63 HIS A CE1 1 ATOM 505 N NE2 . HIS A 1 63 ? 33.685 -20.314 -12.282 1.00 33.32 ? 63 HIS A NE2 1 ATOM 506 N N . TYR A 1 64 ? 37.615 -14.978 -13.233 1.00 32.67 ? 64 TYR A N 1 ATOM 507 C CA . TYR A 1 64 ? 38.666 -13.977 -13.046 1.00 32.03 ? 64 TYR A CA 1 ATOM 508 C C . TYR A 1 64 ? 38.160 -12.604 -13.457 1.00 35.75 ? 64 TYR A C 1 ATOM 509 O O . TYR A 1 64 ? 38.204 -11.691 -12.642 1.00 36.64 ? 64 TYR A O 1 ATOM 510 C CB . TYR A 1 64 ? 39.941 -14.369 -13.841 1.00 33.37 ? 64 TYR A CB 1 ATOM 511 C CG . TYR A 1 64 ? 41.062 -13.352 -13.759 1.00 34.28 ? 64 TYR A CG 1 ATOM 512 C CD1 . TYR A 1 64 ? 42.010 -13.411 -12.743 1.00 35.63 ? 64 TYR A CD1 1 ATOM 513 C CD2 . TYR A 1 64 ? 41.164 -12.317 -14.688 1.00 34.72 ? 64 TYR A CD2 1 ATOM 514 C CE1 . TYR A 1 64 ? 43.029 -12.466 -12.650 1.00 35.55 ? 64 TYR A CE1 1 ATOM 515 C CE2 . TYR A 1 64 ? 42.158 -11.348 -14.584 1.00 35.25 ? 64 TYR A CE2 1 ATOM 516 C CZ . TYR A 1 64 ? 43.097 -11.435 -13.571 1.00 42.11 ? 64 TYR A CZ 1 ATOM 517 O OH . TYR A 1 64 ? 44.106 -10.510 -13.486 1.00 44.42 ? 64 TYR A OH 1 ATOM 518 N N . ARG A 1 65 ? 37.678 -12.458 -14.710 1.00 31.99 ? 65 ARG A N 1 ATOM 519 C CA . ARG A 1 65 ? 37.151 -11.195 -15.252 1.00 31.54 ? 65 ARG A CA 1 ATOM 520 C C . ARG A 1 65 ? 35.848 -10.777 -14.572 1.00 35.77 ? 65 ARG A C 1 ATOM 521 O O . ARG A 1 65 ? 35.585 -9.581 -14.469 1.00 35.02 ? 65 ARG A O 1 ATOM 522 C CB . ARG A 1 65 ? 36.949 -11.295 -16.772 1.00 30.62 ? 65 ARG A CB 1 ATOM 523 C CG . ARG A 1 65 ? 38.253 -11.430 -17.544 1.00 28.91 ? 65 ARG A CG 1 ATOM 524 C CD . ARG A 1 65 ? 38.001 -11.650 -19.017 1.00 27.49 ? 65 ARG A CD 1 ATOM 525 N NE . ARG A 1 65 ? 37.601 -13.018 -19.346 1.00 31.56 ? 65 ARG A NE 1 ATOM 526 C CZ . ARG A 1 65 ? 38.446 -14.040 -19.485 1.00 51.59 ? 65 ARG A CZ 1 ATOM 527 N NH1 . ARG A 1 65 ? 39.753 -13.870 -19.274 1.00 31.99 ? 65 ARG A NH1 1 ATOM 528 N NH2 . ARG A 1 65 ? 37.993 -15.241 -19.818 1.00 40.24 ? 65 ARG A NH2 1 ATOM 529 N N . ASP A 1 66 ? 35.039 -11.767 -14.107 1.00 33.07 ? 66 ASP A N 1 ATOM 530 C CA . ASP A 1 66 ? 33.784 -11.558 -13.370 1.00 32.55 ? 66 ASP A CA 1 ATOM 531 C C . ASP A 1 66 ? 34.118 -10.863 -12.065 1.00 34.41 ? 66 ASP A C 1 ATOM 532 O O . ASP A 1 66 ? 33.582 -9.786 -11.814 1.00 35.05 ? 66 ASP A O 1 ATOM 533 C CB . ASP A 1 66 ? 33.059 -12.894 -13.061 1.00 34.60 ? 66 ASP A CB 1 ATOM 534 C CG . ASP A 1 66 ? 32.308 -13.569 -14.193 1.00 45.95 ? 66 ASP A CG 1 ATOM 535 O OD1 . ASP A 1 66 ? 32.213 -12.972 -15.295 1.00 45.90 ? 66 ASP A OD1 1 ATOM 536 O OD2 . ASP A 1 66 ? 31.811 -14.699 -13.979 1.00 54.25 ? 66 ASP A OD2 1 ATOM 537 N N . VAL A 1 67 ? 35.033 -11.462 -11.260 1.00 28.24 ? 67 VAL A N 1 ATOM 538 C CA . VAL A 1 67 ? 35.498 -10.903 -9.989 1.00 28.77 ? 67 VAL A CA 1 ATOM 539 C C . VAL A 1 67 ? 36.114 -9.506 -10.244 1.00 36.28 ? 67 VAL A C 1 ATOM 540 O O . VAL A 1 67 ? 35.768 -8.544 -9.543 1.00 36.58 ? 67 VAL A O 1 ATOM 541 C CB . VAL A 1 67 ? 36.468 -11.876 -9.236 1.00 31.81 ? 67 VAL A CB 1 ATOM 542 C CG1 . VAL A 1 67 ? 37.100 -11.212 -8.017 1.00 31.06 ? 67 VAL A CG1 1 ATOM 543 C CG2 . VAL A 1 67 ? 35.753 -13.154 -8.813 1.00 31.64 ? 67 VAL A CG2 1 ATOM 544 N N . LEU A 1 68 ? 36.988 -9.399 -11.283 1.00 32.44 ? 68 LEU A N 1 ATOM 545 C CA . LEU A 1 68 ? 37.655 -8.156 -11.652 1.00 31.14 ? 68 LEU A CA 1 ATOM 546 C C . LEU A 1 68 ? 36.670 -7.049 -11.946 1.00 35.47 ? 68 LEU A C 1 ATOM 547 O O . LEU A 1 68 ? 36.870 -5.941 -11.444 1.00 36.90 ? 68 LEU A O 1 ATOM 548 C CB . LEU A 1 68 ? 38.640 -8.359 -12.814 1.00 30.59 ? 68 LEU A CB 1 ATOM 549 C CG . LEU A 1 68 ? 39.392 -7.123 -13.348 1.00 33.47 ? 68 LEU A CG 1 ATOM 550 C CD1 . LEU A 1 68 ? 40.170 -6.408 -12.257 1.00 32.80 ? 68 LEU A CD1 1 ATOM 551 C CD2 . LEU A 1 68 ? 40.310 -7.508 -14.479 1.00 34.22 ? 68 LEU A CD2 1 ATOM 552 N N . LYS A 1 69 ? 35.596 -7.352 -12.705 1.00 30.74 ? 69 LYS A N 1 ATOM 553 C CA . LYS A 1 69 ? 34.550 -6.388 -13.072 1.00 30.22 ? 69 LYS A CA 1 ATOM 554 C C . LYS A 1 69 ? 33.875 -5.833 -11.809 1.00 35.20 ? 69 LYS A C 1 ATOM 555 O O . LYS A 1 69 ? 33.592 -4.634 -11.756 1.00 35.95 ? 69 LYS A O 1 ATOM 556 C CB . LYS A 1 69 ? 33.512 -7.040 -14.004 1.00 31.94 ? 69 LYS A CB 1 ATOM 557 C CG . LYS A 1 69 ? 32.709 -6.028 -14.790 1.00 43.96 ? 69 LYS A CG 1 ATOM 558 C CD . LYS A 1 69 ? 31.446 -6.618 -15.398 1.00 47.99 ? 69 LYS A CD 1 ATOM 559 C CE . LYS A 1 69 ? 30.590 -5.532 -15.995 1.00 55.29 ? 69 LYS A CE 1 ATOM 560 N NZ . LYS A 1 69 ? 29.291 -6.068 -16.479 1.00 70.38 ? 69 LYS A NZ 1 ATOM 561 N N . GLU A 1 70 ? 33.672 -6.699 -10.781 1.00 30.35 ? 70 GLU A N 1 ATOM 562 C CA . GLU A 1 70 ? 33.068 -6.338 -9.498 1.00 30.07 ? 70 GLU A CA 1 ATOM 563 C C . GLU A 1 70 ? 34.001 -5.394 -8.740 1.00 34.24 ? 70 GLU A C 1 ATOM 564 O O . GLU A 1 70 ? 33.565 -4.339 -8.283 1.00 35.59 ? 70 GLU A O 1 ATOM 565 C CB . GLU A 1 70 ? 32.803 -7.595 -8.642 1.00 31.57 ? 70 GLU A CB 1 ATOM 566 C CG . GLU A 1 70 ? 31.893 -8.629 -9.280 1.00 45.59 ? 70 GLU A CG 1 ATOM 567 C CD . GLU A 1 70 ? 31.557 -9.836 -8.429 1.00 71.94 ? 70 GLU A CD 1 ATOM 568 O OE1 . GLU A 1 70 ? 32.067 -9.930 -7.289 1.00 63.09 ? 70 GLU A OE1 1 ATOM 569 O OE2 . GLU A 1 70 ? 30.788 -10.699 -8.912 1.00 76.78 ? 70 GLU A OE2 1 ATOM 570 N N . MET A 1 71 ? 35.283 -5.788 -8.600 1.00 28.42 ? 71 MET A N 1 ATOM 571 C CA . MET A 1 71 ? 36.321 -5.015 -7.921 1.00 27.02 ? 71 MET A CA 1 ATOM 572 C C . MET A 1 71 ? 36.456 -3.605 -8.540 1.00 28.58 ? 71 MET A C 1 ATOM 573 O O . MET A 1 71 ? 36.469 -2.630 -7.796 1.00 27.09 ? 71 MET A O 1 ATOM 574 C CB . MET A 1 71 ? 37.659 -5.765 -7.995 1.00 28.86 ? 71 MET A CB 1 ATOM 575 C CG . MET A 1 71 ? 37.692 -7.061 -7.205 1.00 30.42 ? 71 MET A CG 1 ATOM 576 S SD . MET A 1 71 ? 39.257 -7.932 -7.403 1.00 31.92 ? 71 MET A SD 1 ATOM 577 C CE . MET A 1 71 ? 40.353 -6.868 -6.479 1.00 27.93 ? 71 MET A CE 1 ATOM 578 N N . LYS A 1 72 ? 36.507 -3.511 -9.899 1.00 25.02 ? 72 LYS A N 1 ATOM 579 C CA . LYS A 1 72 ? 36.547 -2.256 -10.678 1.00 25.05 ? 72 LYS A CA 1 ATOM 580 C C . LYS A 1 72 ? 35.289 -1.381 -10.456 1.00 33.34 ? 72 LYS A C 1 ATOM 581 O O . LYS A 1 72 ? 35.385 -0.146 -10.512 1.00 32.49 ? 72 LYS A O 1 ATOM 582 C CB . LYS A 1 72 ? 36.715 -2.534 -12.178 1.00 25.29 ? 72 LYS A CB 1 ATOM 583 C CG . LYS A 1 72 ? 38.133 -2.839 -12.609 1.00 24.12 ? 72 LYS A CG 1 ATOM 584 C CD . LYS A 1 72 ? 38.317 -2.558 -14.065 1.00 30.95 ? 72 LYS A CD 1 ATOM 585 C CE . LYS A 1 72 ? 39.136 -3.644 -14.734 1.00 53.31 ? 72 LYS A CE 1 ATOM 586 N NZ . LYS A 1 72 ? 39.957 -3.139 -15.881 1.00 52.57 ? 72 LYS A NZ 1 ATOM 587 N N . ALA A 1 73 ? 34.114 -2.026 -10.196 1.00 32.35 ? 73 ALA A N 1 ATOM 588 C CA . ALA A 1 73 ? 32.859 -1.321 -9.915 1.00 32.81 ? 73 ALA A CA 1 ATOM 589 C C . ALA A 1 73 ? 32.919 -0.632 -8.546 1.00 38.02 ? 73 ALA A C 1 ATOM 590 O O . ALA A 1 73 ? 32.422 0.495 -8.393 1.00 37.41 ? 73 ALA A O 1 ATOM 591 C CB . ALA A 1 73 ? 31.671 -2.279 -9.989 1.00 33.53 ? 73 ALA A CB 1 ATOM 592 N N . LYS A 1 74 ? 33.535 -1.305 -7.554 1.00 36.08 ? 74 LYS A N 1 ATOM 593 C CA . LYS A 1 74 ? 33.697 -0.760 -6.203 1.00 36.34 ? 74 LYS A CA 1 ATOM 594 C C . LYS A 1 74 ? 34.791 0.316 -6.205 1.00 41.56 ? 74 LYS A C 1 ATOM 595 O O . LYS A 1 74 ? 34.601 1.380 -5.608 1.00 42.05 ? 74 LYS A O 1 ATOM 596 C CB . LYS A 1 74 ? 33.993 -1.870 -5.190 1.00 39.14 ? 74 LYS A CB 1 ATOM 597 C CG . LYS A 1 74 ? 32.894 -2.930 -5.104 1.00 62.65 ? 74 LYS A CG 1 ATOM 598 C CD . LYS A 1 74 ? 33.062 -3.825 -3.887 1.00 79.93 ? 74 LYS A CD 1 ATOM 599 C CE . LYS A 1 74 ? 32.730 -5.273 -4.174 1.00 98.14 ? 74 LYS A CE 1 ATOM 600 N NZ . LYS A 1 74 ? 33.896 -6.016 -4.730 1.00 109.85 ? 74 LYS A NZ 1 ATOM 601 N N . ALA A 1 75 ? 35.903 0.066 -6.944 1.00 37.59 ? 75 ALA A N 1 ATOM 602 C CA . ALA A 1 75 ? 37.038 0.984 -7.116 1.00 36.82 ? 75 ALA A CA 1 ATOM 603 C C . ALA A 1 75 ? 36.623 2.337 -7.714 1.00 40.70 ? 75 ALA A C 1 ATOM 604 O O . ALA A 1 75 ? 37.228 3.354 -7.393 1.00 41.15 ? 75 ALA A O 1 ATOM 605 C CB . ALA A 1 75 ? 38.098 0.342 -8.001 1.00 37.28 ? 75 ALA A CB 1 ATOM 606 N N . SER A 1 76 ? 35.595 2.350 -8.574 1.00 36.33 ? 76 SER A N 1 ATOM 607 C CA . SER A 1 76 ? 35.116 3.572 -9.219 1.00 35.21 ? 76 SER A CA 1 ATOM 608 C C . SER A 1 76 ? 34.359 4.504 -8.263 1.00 40.10 ? 76 SER A C 1 ATOM 609 O O . SER A 1 76 ? 34.109 5.656 -8.628 1.00 39.98 ? 76 SER A O 1 ATOM 610 C CB . SER A 1 76 ? 34.304 3.250 -10.469 1.00 36.24 ? 76 SER A CB 1 ATOM 611 O OG . SER A 1 76 ? 33.090 2.592 -10.163 1.00 44.50 ? 76 SER A OG 1 ATOM 612 N N . THR A 1 77 ? 34.039 4.031 -7.026 1.00 36.29 ? 77 THR A N 1 ATOM 613 C CA . THR A 1 77 ? 33.378 4.848 -5.984 1.00 35.03 ? 77 THR A CA 1 ATOM 614 C C . THR A 1 77 ? 34.413 5.520 -5.064 1.00 35.95 ? 77 THR A C 1 ATOM 615 O O . THR A 1 77 ? 34.042 6.317 -4.200 1.00 33.61 ? 77 THR A O 1 ATOM 616 C CB . THR A 1 77 ? 32.355 4.043 -5.162 1.00 39.02 ? 77 THR A CB 1 ATOM 617 O OG1 . THR A 1 77 ? 33.028 3.317 -4.125 1.00 31.90 ? 77 THR A OG1 1 ATOM 618 C CG2 . THR A 1 77 ? 31.467 3.141 -6.028 1.00 41.25 ? 77 THR A CG2 1 ATOM 619 N N . VAL A 1 78 ? 35.700 5.194 -5.258 1.00 32.86 ? 78 VAL A N 1 ATOM 620 C CA . VAL A 1 78 ? 36.803 5.740 -4.466 1.00 33.58 ? 78 VAL A CA 1 ATOM 621 C C . VAL A 1 78 ? 37.230 7.094 -5.061 1.00 40.01 ? 78 VAL A C 1 ATOM 622 O O . VAL A 1 78 ? 37.320 7.227 -6.282 1.00 39.66 ? 78 VAL A O 1 ATOM 623 C CB . VAL A 1 78 ? 38.025 4.761 -4.385 1.00 37.10 ? 78 VAL A CB 1 ATOM 624 C CG1 . VAL A 1 78 ? 39.085 5.258 -3.411 1.00 37.14 ? 78 VAL A CG1 1 ATOM 625 C CG2 . VAL A 1 78 ? 37.615 3.340 -4.032 1.00 36.44 ? 78 VAL A CG2 1 ATOM 626 N N . LYS A 1 79 ? 37.504 8.083 -4.192 1.00 38.16 ? 79 LYS A N 1 ATOM 627 C CA . LYS A 1 79 ? 38.067 9.384 -4.572 1.00 38.12 ? 79 LYS A CA 1 ATOM 628 C C . LYS A 1 79 ? 39.411 9.477 -3.855 1.00 41.93 ? 79 LYS A C 1 ATOM 629 O O . LYS A 1 79 ? 39.481 9.212 -2.652 1.00 41.50 ? 79 LYS A O 1 ATOM 630 C CB . LYS A 1 79 ? 37.178 10.562 -4.153 1.00 39.97 ? 79 LYS A CB 1 ATOM 631 C CG . LYS A 1 79 ? 37.622 11.881 -4.773 1.00 39.60 ? 79 LYS A CG 1 ATOM 632 C CD . LYS A 1 79 ? 36.930 13.061 -4.125 1.00 41.70 ? 79 LYS A CD 1 ATOM 633 C CE . LYS A 1 79 ? 36.936 14.287 -5.003 1.00 38.10 ? 79 LYS A CE 1 ATOM 634 N NZ . LYS A 1 79 ? 36.007 14.150 -6.158 1.00 49.93 ? 79 LYS A NZ 1 ATOM 635 N N . ALA A 1 80 ? 40.475 9.808 -4.584 1.00 38.51 ? 80 ALA A N 1 ATOM 636 C CA . ALA A 1 80 ? 41.797 9.890 -3.972 1.00 38.41 ? 80 ALA A CA 1 ATOM 637 C C . ALA A 1 80 ? 42.472 11.231 -4.179 1.00 41.50 ? 80 ALA A C 1 ATOM 638 O O . ALA A 1 80 ? 42.386 11.808 -5.266 1.00 40.58 ? 80 ALA A O 1 ATOM 639 C CB . ALA A 1 80 ? 42.681 8.765 -4.465 1.00 39.05 ? 80 ALA A CB 1 ATOM 640 N N . LYS A 1 81 ? 43.140 11.729 -3.124 1.00 37.76 ? 81 LYS A N 1 ATOM 641 C CA . LYS A 1 81 ? 43.818 13.019 -3.166 1.00 37.37 ? 81 LYS A CA 1 ATOM 642 C C . LYS A 1 81 ? 45.296 12.883 -3.468 1.00 40.32 ? 81 LYS A C 1 ATOM 643 O O . LYS A 1 81 ? 45.943 11.939 -3.015 1.00 40.42 ? 81 LYS A O 1 ATOM 644 C CB . LYS A 1 81 ? 43.556 13.866 -1.889 1.00 39.72 ? 81 LYS A CB 1 ATOM 645 C CG . LYS A 1 81 ? 44.282 13.417 -0.625 1.00 58.22 ? 81 LYS A CG 1 ATOM 646 C CD . LYS A 1 81 ? 44.010 14.331 0.574 1.00 73.77 ? 81 LYS A CD 1 ATOM 647 C CE . LYS A 1 81 ? 44.683 13.815 1.832 1.00 86.33 ? 81 LYS A CE 1 ATOM 648 N NZ . LYS A 1 81 ? 44.381 14.653 3.019 1.00 90.30 ? 81 LYS A NZ 1 ATOM 649 N N . LEU A 1 82 ? 45.813 13.834 -4.247 1.00 36.74 ? 82 LEU A N 1 ATOM 650 C CA . LEU A 1 82 ? 47.214 13.970 -4.615 1.00 37.24 ? 82 LEU A CA 1 ATOM 651 C C . LEU A 1 82 ? 47.920 14.643 -3.434 1.00 43.95 ? 82 LEU A C 1 ATOM 652 O O . LEU A 1 82 ? 47.518 15.725 -2.990 1.00 45.16 ? 82 LEU A O 1 ATOM 653 C CB . LEU A 1 82 ? 47.299 14.854 -5.868 1.00 37.61 ? 82 LEU A CB 1 ATOM 654 C CG . LEU A 1 82 ? 48.636 14.966 -6.596 1.00 43.33 ? 82 LEU A CG 1 ATOM 655 C CD1 . LEU A 1 82 ? 49.074 13.628 -7.210 1.00 42.89 ? 82 LEU A CD1 1 ATOM 656 C CD2 . LEU A 1 82 ? 48.527 15.974 -7.705 1.00 47.60 ? 82 LEU A CD2 1 ATOM 657 N N . LEU A 1 83 ? 48.908 13.979 -2.868 1.00 40.90 ? 83 LEU A N 1 ATOM 658 C CA . LEU A 1 83 ? 49.617 14.543 -1.727 1.00 41.25 ? 83 LEU A CA 1 ATOM 659 C C . LEU A 1 83 ? 50.614 15.595 -2.203 1.00 47.26 ? 83 LEU A C 1 ATOM 660 O O . LEU A 1 83 ? 51.062 15.539 -3.351 1.00 46.81 ? 83 LEU A O 1 ATOM 661 C CB . LEU A 1 83 ? 50.327 13.413 -0.968 1.00 41.23 ? 83 LEU A CB 1 ATOM 662 C CG . LEU A 1 83 ? 49.705 12.937 0.351 1.00 45.96 ? 83 LEU A CG 1 ATOM 663 C CD1 . LEU A 1 83 ? 48.306 12.331 0.167 1.00 44.95 ? 83 LEU A CD1 1 ATOM 664 C CD2 . LEU A 1 83 ? 50.595 11.929 0.993 1.00 50.01 ? 83 LEU A CD2 1 ATOM 665 N N . SER A 1 84 ? 50.920 16.580 -1.349 1.00 45.64 ? 84 SER A N 1 ATOM 666 C CA . SER A 1 84 ? 51.895 17.623 -1.679 1.00 45.73 ? 84 SER A CA 1 ATOM 667 C C . SER A 1 84 ? 53.286 17.090 -1.347 1.00 49.12 ? 84 SER A C 1 ATOM 668 O O . SER A 1 84 ? 53.401 16.135 -0.565 1.00 48.75 ? 84 SER A O 1 ATOM 669 C CB . SER A 1 84 ? 51.611 18.908 -0.902 1.00 49.84 ? 84 SER A CB 1 ATOM 670 O OG . SER A 1 84 ? 51.735 18.748 0.503 1.00 61.40 ? 84 SER A OG 1 ATOM 671 N N . VAL A 1 85 ? 54.339 17.699 -1.941 1.00 44.56 ? 85 VAL A N 1 ATOM 672 C CA . VAL A 1 85 ? 55.732 17.311 -1.702 1.00 43.68 ? 85 VAL A CA 1 ATOM 673 C C . VAL A 1 85 ? 55.948 17.215 -0.192 1.00 48.48 ? 85 VAL A C 1 ATOM 674 O O . VAL A 1 85 ? 56.371 16.165 0.283 1.00 48.34 ? 85 VAL A O 1 ATOM 675 C CB . VAL A 1 85 ? 56.749 18.249 -2.400 1.00 47.33 ? 85 VAL A CB 1 ATOM 676 C CG1 . VAL A 1 85 ? 58.187 17.869 -2.053 1.00 47.43 ? 85 VAL A CG1 1 ATOM 677 C CG2 . VAL A 1 85 ? 56.555 18.240 -3.903 1.00 47.01 ? 85 VAL A CG2 1 ATOM 678 N N . GLU A 1 86 ? 55.539 18.264 0.553 1.00 45.75 ? 86 GLU A N 1 ATOM 679 C CA . GLU A 1 86 ? 55.599 18.370 2.010 1.00 45.60 ? 86 GLU A CA 1 ATOM 680 C C . GLU A 1 86 ? 54.889 17.199 2.672 1.00 49.97 ? 86 GLU A C 1 ATOM 681 O O . GLU A 1 86 ? 55.486 16.539 3.533 1.00 50.10 ? 86 GLU A O 1 ATOM 682 C CB . GLU A 1 86 ? 54.964 19.694 2.486 1.00 47.28 ? 86 GLU A CB 1 ATOM 683 C CG . GLU A 1 86 ? 55.849 20.922 2.366 1.00 61.47 ? 86 GLU A CG 1 ATOM 684 C CD . GLU A 1 86 ? 56.186 21.350 0.953 1.00 78.27 ? 86 GLU A CD 1 ATOM 685 O OE1 . GLU A 1 86 ? 55.239 21.621 0.177 1.00 69.79 ? 86 GLU A OE1 1 ATOM 686 O OE2 . GLU A 1 86 ? 57.393 21.451 0.632 1.00 65.23 ? 86 GLU A OE2 1 ATOM 687 N N . GLU A 1 87 ? 53.619 16.926 2.270 1.00 45.89 ? 87 GLU A N 1 ATOM 688 C CA . GLU A 1 87 ? 52.808 15.832 2.828 1.00 45.12 ? 87 GLU A CA 1 ATOM 689 C C . GLU A 1 87 ? 53.487 14.485 2.624 1.00 47.90 ? 87 GLU A C 1 ATOM 690 O O . GLU A 1 87 ? 53.591 13.706 3.572 1.00 48.86 ? 87 GLU A O 1 ATOM 691 C CB . GLU A 1 87 ? 51.393 15.821 2.238 1.00 46.27 ? 87 GLU A CB 1 ATOM 692 C CG . GLU A 1 87 ? 50.423 16.785 2.894 1.00 51.85 ? 87 GLU A CG 1 ATOM 693 C CD . GLU A 1 87 ? 49.091 16.862 2.173 1.00 74.69 ? 87 GLU A CD 1 ATOM 694 O OE1 . GLU A 1 87 ? 49.080 17.209 0.968 1.00 52.29 ? 87 GLU A OE1 1 ATOM 695 O OE2 . GLU A 1 87 ? 48.057 16.560 2.810 1.00 79.14 ? 87 GLU A OE2 1 ATOM 696 N N . ALA A 1 88 ? 53.997 14.243 1.408 1.00 42.23 ? 88 ALA A N 1 ATOM 697 C CA . ALA A 1 88 ? 54.708 13.022 1.048 1.00 41.52 ? 88 ALA A CA 1 ATOM 698 C C . ALA A 1 88 ? 56.039 12.880 1.816 1.00 44.89 ? 88 ALA A C 1 ATOM 699 O O . ALA A 1 88 ? 56.353 11.784 2.274 1.00 44.61 ? 88 ALA A O 1 ATOM 700 C CB . ALA A 1 88 ? 54.940 12.992 -0.445 1.00 42.26 ? 88 ALA A CB 1 ATOM 701 N N . CYS A 1 89 ? 56.783 13.995 1.996 1.00 41.23 ? 89 CYS A N 1 ATOM 702 C CA . CYS A 1 89 ? 58.061 14.090 2.727 1.00 40.70 ? 89 CYS A CA 1 ATOM 703 C C . CYS A 1 89 ? 57.906 13.722 4.203 1.00 45.84 ? 89 CYS A C 1 ATOM 704 O O . CYS A 1 89 ? 58.832 13.181 4.807 1.00 45.86 ? 89 CYS A O 1 ATOM 705 C CB . CYS A 1 89 ? 58.663 15.489 2.587 1.00 40.45 ? 89 CYS A CB 1 ATOM 706 S SG . CYS A 1 89 ? 59.551 15.797 1.035 1.00 43.76 ? 89 CYS A SG 1 ATOM 707 N N . LYS A 1 90 ? 56.758 14.079 4.796 1.00 43.52 ? 90 LYS A N 1 ATOM 708 C CA . LYS A 1 90 ? 56.459 13.824 6.211 1.00 43.07 ? 90 LYS A CA 1 ATOM 709 C C . LYS A 1 90 ? 56.104 12.355 6.492 1.00 45.95 ? 90 LYS A C 1 ATOM 710 O O . LYS A 1 90 ? 56.222 11.902 7.629 1.00 45.67 ? 90 LYS A O 1 ATOM 711 C CB . LYS A 1 90 ? 55.377 14.796 6.722 1.00 44.36 ? 90 LYS A CB 1 ATOM 712 C CG . LYS A 1 90 ? 55.832 16.259 6.737 1.00 47.01 ? 90 LYS A CG 1 ATOM 713 C CD . LYS A 1 90 ? 56.985 16.507 7.715 1.00 49.67 ? 90 LYS A CD 1 ATOM 714 C CE . LYS A 1 90 ? 57.512 17.913 7.649 1.00 54.94 ? 90 LYS A CE 1 ATOM 715 N NZ . LYS A 1 90 ? 58.537 18.157 8.696 1.00 55.80 ? 90 LYS A NZ 1 ATOM 716 N N . LEU A 1 91 ? 55.688 11.617 5.451 1.00 41.60 ? 91 LEU A N 1 ATOM 717 C CA . LEU A 1 91 ? 55.357 10.199 5.551 1.00 41.52 ? 91 LEU A CA 1 ATOM 718 C C . LEU A 1 91 ? 56.591 9.300 5.321 1.00 46.40 ? 91 LEU A C 1 ATOM 719 O O . LEU A 1 91 ? 56.447 8.077 5.292 1.00 45.14 ? 91 LEU A O 1 ATOM 720 C CB . LEU A 1 91 ? 54.259 9.839 4.544 1.00 41.40 ? 91 LEU A CB 1 ATOM 721 C CG . LEU A 1 91 ? 52.853 10.331 4.843 1.00 45.72 ? 91 LEU A CG 1 ATOM 722 C CD1 . LEU A 1 91 ? 52.030 10.280 3.610 1.00 45.03 ? 91 LEU A CD1 1 ATOM 723 C CD2 . LEU A 1 91 ? 52.185 9.515 5.957 1.00 47.75 ? 91 LEU A CD2 1 ATOM 724 N N . THR A 1 92 ? 57.796 9.901 5.170 1.00 44.22 ? 92 THR A N 1 ATOM 725 C CA . THR A 1 92 ? 59.043 9.172 4.912 1.00 44.58 ? 92 THR A CA 1 ATOM 726 C C . THR A 1 92 ? 59.716 8.665 6.209 1.00 51.40 ? 92 THR A C 1 ATOM 727 O O . THR A 1 92 ? 60.045 9.481 7.071 1.00 50.61 ? 92 THR A O 1 ATOM 728 C CB . THR A 1 92 ? 59.997 10.028 4.042 1.00 45.97 ? 92 THR A CB 1 ATOM 729 O OG1 . THR A 1 92 ? 59.300 10.494 2.887 1.00 47.07 ? 92 THR A OG1 1 ATOM 730 C CG2 . THR A 1 92 ? 61.260 9.281 3.621 1.00 40.57 ? 92 THR A CG2 1 ATOM 731 N N . PRO A 1 93 ? 59.998 7.341 6.331 1.00 50.47 ? 93 PRO A N 1 ATOM 732 C CA . PRO A 1 93 ? 60.703 6.831 7.534 1.00 50.96 ? 93 PRO A CA 1 ATOM 733 C C . PRO A 1 93 ? 62.010 7.578 7.827 1.00 56.11 ? 93 PRO A C 1 ATOM 734 O O . PRO A 1 93 ? 62.656 8.018 6.879 1.00 54.68 ? 93 PRO A O 1 ATOM 735 C CB . PRO A 1 93 ? 60.950 5.356 7.204 1.00 52.34 ? 93 PRO A CB 1 ATOM 736 C CG . PRO A 1 93 ? 59.884 5.014 6.228 1.00 56.40 ? 93 PRO A CG 1 ATOM 737 C CD . PRO A 1 93 ? 59.683 6.245 5.395 1.00 51.72 ? 93 PRO A CD 1 ATOM 738 N N . PRO A 1 94 ? 62.385 7.819 9.111 1.00 54.50 ? 94 PRO A N 1 ATOM 739 C CA . PRO A 1 94 ? 63.609 8.606 9.371 1.00 54.48 ? 94 PRO A CA 1 ATOM 740 C C . PRO A 1 94 ? 64.908 7.903 8.985 1.00 57.19 ? 94 PRO A C 1 ATOM 741 O O . PRO A 1 94 ? 65.890 8.568 8.661 1.00 56.67 ? 94 PRO A O 1 ATOM 742 C CB . PRO A 1 94 ? 63.545 8.916 10.875 1.00 56.16 ? 94 PRO A CB 1 ATOM 743 C CG . PRO A 1 94 ? 62.237 8.390 11.354 1.00 60.14 ? 94 PRO A CG 1 ATOM 744 C CD . PRO A 1 94 ? 61.740 7.396 10.371 1.00 55.52 ? 94 PRO A CD 1 ATOM 745 N N . HIS A 1 95 ? 64.906 6.568 9.022 1.00 53.35 ? 95 HIS A N 1 ATOM 746 C CA . HIS A 1 95 ? 66.069 5.756 8.696 1.00 53.68 ? 95 HIS A CA 1 ATOM 747 C C . HIS A 1 95 ? 65.852 4.995 7.363 1.00 55.00 ? 95 HIS A C 1 ATOM 748 O O . HIS A 1 95 ? 66.333 3.870 7.166 1.00 55.59 ? 95 HIS A O 1 ATOM 749 C CB . HIS A 1 95 ? 66.459 4.861 9.899 1.00 55.58 ? 95 HIS A CB 1 ATOM 750 C CG . HIS A 1 95 ? 66.803 5.662 11.130 1.00 59.92 ? 95 HIS A CG 1 ATOM 751 N ND1 . HIS A 1 95 ? 65.852 5.939 12.112 1.00 61.97 ? 95 HIS A ND1 1 ATOM 752 C CD2 . HIS A 1 95 ? 67.968 6.275 11.468 1.00 62.15 ? 95 HIS A CD2 1 ATOM 753 C CE1 . HIS A 1 95 ? 66.474 6.690 13.012 1.00 61.67 ? 95 HIS A CE1 1 ATOM 754 N NE2 . HIS A 1 95 ? 67.751 6.914 12.672 1.00 61.97 ? 95 HIS A NE2 1 ATOM 755 N N . SER A 1 96 ? 65.147 5.667 6.430 1.00 47.18 ? 96 SER A N 1 ATOM 756 C CA . SER A 1 96 ? 64.853 5.189 5.084 1.00 44.72 ? 96 SER A CA 1 ATOM 757 C C . SER A 1 96 ? 66.116 5.376 4.252 1.00 44.87 ? 96 SER A C 1 ATOM 758 O O . SER A 1 96 ? 66.903 6.280 4.538 1.00 43.79 ? 96 SER A O 1 ATOM 759 C CB . SER A 1 96 ? 63.694 5.991 4.496 1.00 47.84 ? 96 SER A CB 1 ATOM 760 O OG . SER A 1 96 ? 63.477 5.742 3.119 1.00 55.76 ? 96 SER A OG 1 ATOM 761 N N . ALA A 1 97 ? 66.316 4.519 3.234 1.00 39.78 ? 97 ALA A N 1 ATOM 762 C CA . ALA A 1 97 ? 67.486 4.518 2.356 1.00 38.37 ? 97 ALA A CA 1 ATOM 763 C C . ALA A 1 97 ? 67.722 5.871 1.684 1.00 43.97 ? 97 ALA A C 1 ATOM 764 O O . ALA A 1 97 ? 66.797 6.446 1.101 1.00 44.37 ? 97 ALA A O 1 ATOM 765 C CB . ALA A 1 97 ? 67.353 3.426 1.320 1.00 38.38 ? 97 ALA A CB 1 ATOM 766 N N . LYS A 1 98 ? 68.958 6.400 1.819 1.00 39.88 ? 98 LYS A N 1 ATOM 767 C CA . LYS A 1 98 ? 69.385 7.686 1.255 1.00 38.97 ? 98 LYS A CA 1 ATOM 768 C C . LYS A 1 98 ? 69.332 7.680 -0.276 1.00 41.63 ? 98 LYS A C 1 ATOM 769 O O . LYS A 1 98 ? 69.564 6.645 -0.901 1.00 40.51 ? 98 LYS A O 1 ATOM 770 C CB . LYS A 1 98 ? 70.801 8.076 1.762 1.00 41.03 ? 98 LYS A CB 1 ATOM 771 C CG . LYS A 1 98 ? 71.932 7.160 1.272 1.00 59.04 ? 98 LYS A CG 1 ATOM 772 C CD . LYS A 1 98 ? 73.244 7.388 1.996 1.00 74.24 ? 98 LYS A CD 1 ATOM 773 C CE . LYS A 1 98 ? 74.226 6.260 1.767 1.00 90.32 ? 98 LYS A CE 1 ATOM 774 N NZ . LYS A 1 98 ? 74.832 6.310 0.409 1.00 102.65 ? 98 LYS A NZ 1 ATOM 775 N N . SER A 1 99 ? 69.035 8.841 -0.866 1.00 38.59 ? 99 SER A N 1 ATOM 776 C CA . SER A 1 99 ? 68.988 9.018 -2.316 1.00 38.56 ? 99 SER A CA 1 ATOM 777 C C . SER A 1 99 ? 70.404 9.040 -2.897 1.00 45.81 ? 99 SER A C 1 ATOM 778 O O . SER A 1 99 ? 71.329 9.545 -2.251 1.00 47.46 ? 99 SER A O 1 ATOM 779 C CB . SER A 1 99 ? 68.263 10.316 -2.661 1.00 39.01 ? 99 SER A CB 1 ATOM 780 O OG . SER A 1 99 ? 68.378 10.672 -4.029 1.00 38.58 ? 99 SER A OG 1 ATOM 781 N N . LYS A 1 100 ? 70.558 8.531 -4.133 1.00 41.91 ? 100 LYS A N 1 ATOM 782 C CA . LYS A 1 100 ? 71.819 8.509 -4.881 1.00 41.36 ? 100 LYS A CA 1 ATOM 783 C C . LYS A 1 100 ? 72.203 9.929 -5.286 1.00 46.47 ? 100 LYS A C 1 ATOM 784 O O . LYS A 1 100 ? 73.335 10.162 -5.685 1.00 46.94 ? 100 LYS A O 1 ATOM 785 C CB . LYS A 1 100 ? 71.668 7.633 -6.146 1.00 43.46 ? 100 LYS A CB 1 ATOM 786 C CG . LYS A 1 100 ? 71.652 6.123 -5.883 1.00 49.79 ? 100 LYS A CG 1 ATOM 787 C CD . LYS A 1 100 ? 71.463 5.296 -7.164 1.00 54.74 ? 100 LYS A CD 1 ATOM 788 C CE . LYS A 1 100 ? 71.668 3.812 -6.928 1.00 57.46 ? 100 LYS A CE 1 ATOM 789 N NZ . LYS A 1 100 ? 71.079 2.978 -8.014 1.00 49.16 ? 100 LYS A NZ 1 ATOM 790 N N . PHE A 1 101 ? 71.255 10.872 -5.172 1.00 44.40 ? 101 PHE A N 1 ATOM 791 C CA . PHE A 1 101 ? 71.356 12.277 -5.570 1.00 44.57 ? 101 PHE A CA 1 ATOM 792 C C . PHE A 1 101 ? 71.677 13.231 -4.411 1.00 50.56 ? 101 PHE A C 1 ATOM 793 O O . PHE A 1 101 ? 71.306 14.414 -4.447 1.00 50.45 ? 101 PHE A O 1 ATOM 794 C CB . PHE A 1 101 ? 70.081 12.692 -6.311 1.00 46.21 ? 101 PHE A CB 1 ATOM 795 C CG . PHE A 1 101 ? 69.862 11.904 -7.581 1.00 48.06 ? 101 PHE A CG 1 ATOM 796 C CD1 . PHE A 1 101 ? 69.243 10.658 -7.550 1.00 51.02 ? 101 PHE A CD1 1 ATOM 797 C CD2 . PHE A 1 101 ? 70.299 12.395 -8.806 1.00 50.74 ? 101 PHE A CD2 1 ATOM 798 C CE1 . PHE A 1 101 ? 69.066 9.923 -8.719 1.00 52.37 ? 101 PHE A CE1 1 ATOM 799 C CE2 . PHE A 1 101 ? 70.116 11.661 -9.977 1.00 53.47 ? 101 PHE A CE2 1 ATOM 800 C CZ . PHE A 1 101 ? 69.506 10.427 -9.925 1.00 51.80 ? 101 PHE A CZ 1 ATOM 801 N N . GLY A 1 102 ? 72.408 12.720 -3.416 1.00 47.36 ? 102 GLY A N 1 ATOM 802 C CA . GLY A 1 102 ? 72.876 13.502 -2.282 1.00 46.73 ? 102 GLY A CA 1 ATOM 803 C C . GLY A 1 102 ? 72.175 13.216 -0.977 1.00 51.56 ? 102 GLY A C 1 ATOM 804 O O . GLY A 1 102 ? 72.667 12.428 -0.158 1.00 53.06 ? 102 GLY A O 1 ATOM 805 N N . TYR A 1 103 ? 71.022 13.878 -0.788 1.00 45.71 ? 103 TYR A N 1 ATOM 806 C CA . TYR A 1 103 ? 70.153 13.881 0.396 1.00 44.00 ? 103 TYR A CA 1 ATOM 807 C C . TYR A 1 103 ? 69.666 12.494 0.923 1.00 47.50 ? 103 TYR A C 1 ATOM 808 O O . TYR A 1 103 ? 69.674 11.491 0.201 1.00 45.30 ? 103 TYR A O 1 ATOM 809 C CB . TYR A 1 103 ? 68.943 14.787 0.110 1.00 43.45 ? 103 TYR A CB 1 ATOM 810 C CG . TYR A 1 103 ? 67.988 14.228 -0.916 1.00 42.73 ? 103 TYR A CG 1 ATOM 811 C CD1 . TYR A 1 103 ? 66.884 13.477 -0.530 1.00 44.33 ? 103 TYR A CD1 1 ATOM 812 C CD2 . TYR A 1 103 ? 68.205 14.419 -2.276 1.00 42.72 ? 103 TYR A CD2 1 ATOM 813 C CE1 . TYR A 1 103 ? 65.995 12.964 -1.471 1.00 44.18 ? 103 TYR A CE1 1 ATOM 814 C CE2 . TYR A 1 103 ? 67.334 13.888 -3.229 1.00 43.05 ? 103 TYR A CE2 1 ATOM 815 C CZ . TYR A 1 103 ? 66.216 13.184 -2.817 1.00 46.54 ? 103 TYR A CZ 1 ATOM 816 O OH . TYR A 1 103 ? 65.334 12.673 -3.725 1.00 42.16 ? 103 TYR A OH 1 ATOM 817 N N . GLY A 1 104 ? 69.196 12.501 2.173 1.00 45.98 ? 104 GLY A N 1 ATOM 818 C CA . GLY A 1 104 ? 68.658 11.331 2.865 1.00 46.28 ? 104 GLY A CA 1 ATOM 819 C C . GLY A 1 104 ? 67.222 11.486 3.349 1.00 50.54 ? 104 GLY A C 1 ATOM 820 O O . GLY A 1 104 ? 66.522 12.452 2.999 1.00 49.80 ? 104 GLY A O 1 ATOM 821 N N . ALA A 1 105 ? 66.762 10.502 4.133 1.00 46.99 ? 105 ALA A N 1 ATOM 822 C CA . ALA A 1 105 ? 65.407 10.484 4.686 1.00 46.72 ? 105 ALA A CA 1 ATOM 823 C C . ALA A 1 105 ? 65.124 11.688 5.590 1.00 50.87 ? 105 ALA A C 1 ATOM 824 O O . ALA A 1 105 ? 64.062 12.299 5.465 1.00 50.77 ? 105 ALA A O 1 ATOM 825 C CB . ALA A 1 105 ? 65.169 9.192 5.434 1.00 47.34 ? 105 ALA A CB 1 ATOM 826 N N . LYS A 1 106 ? 66.088 12.058 6.459 1.00 47.08 ? 106 LYS A N 1 ATOM 827 C CA . LYS A 1 106 ? 65.959 13.206 7.357 1.00 46.55 ? 106 LYS A CA 1 ATOM 828 C C . LYS A 1 106 ? 65.968 14.536 6.569 1.00 49.36 ? 106 LYS A C 1 ATOM 829 O O . LYS A 1 106 ? 65.133 15.393 6.858 1.00 47.92 ? 106 LYS A O 1 ATOM 830 C CB . LYS A 1 106 ? 66.984 13.147 8.500 1.00 49.47 ? 106 LYS A CB 1 ATOM 831 C CG . LYS A 1 106 ? 66.821 11.862 9.331 1.00 69.12 ? 106 LYS A CG 1 ATOM 832 C CD . LYS A 1 106 ? 67.403 11.922 10.740 1.00 82.80 ? 106 LYS A CD 1 ATOM 833 C CE . LYS A 1 106 ? 67.081 10.660 11.518 1.00 94.10 ? 106 LYS A CE 1 ATOM 834 N NZ . LYS A 1 106 ? 67.380 10.798 12.971 1.00 101.47 ? 106 LYS A NZ 1 ATOM 835 N N . ASP A 1 107 ? 66.814 14.656 5.504 1.00 46.30 ? 107 ASP A N 1 ATOM 836 C CA . ASP A 1 107 ? 66.846 15.808 4.578 1.00 46.09 ? 107 ASP A CA 1 ATOM 837 C C . ASP A 1 107 ? 65.436 15.963 4.015 1.00 51.45 ? 107 ASP A C 1 ATOM 838 O O . ASP A 1 107 ? 64.887 17.067 4.025 1.00 51.79 ? 107 ASP A O 1 ATOM 839 C CB . ASP A 1 107 ? 67.795 15.555 3.387 1.00 47.90 ? 107 ASP A CB 1 ATOM 840 C CG . ASP A 1 107 ? 69.278 15.436 3.691 1.00 58.80 ? 107 ASP A CG 1 ATOM 841 O OD1 . ASP A 1 107 ? 69.642 14.626 4.566 1.00 60.53 ? 107 ASP A OD1 1 ATOM 842 O OD2 . ASP A 1 107 ? 70.080 16.080 2.985 1.00 63.42 ? 107 ASP A OD2 1 ATOM 843 N N . VAL A 1 108 ? 64.833 14.821 3.575 1.00 48.30 ? 108 VAL A N 1 ATOM 844 C CA . VAL A 1 108 ? 63.460 14.735 3.056 1.00 47.44 ? 108 VAL A CA 1 ATOM 845 C C . VAL A 1 108 ? 62.475 15.255 4.120 1.00 51.56 ? 108 VAL A C 1 ATOM 846 O O . VAL A 1 108 ? 61.805 16.255 3.880 1.00 50.95 ? 108 VAL A O 1 ATOM 847 C CB . VAL A 1 108 ? 63.113 13.301 2.537 1.00 49.42 ? 108 VAL A CB 1 ATOM 848 C CG1 . VAL A 1 108 ? 61.611 13.076 2.416 1.00 48.59 ? 108 VAL A CG1 1 ATOM 849 C CG2 . VAL A 1 108 ? 63.784 13.030 1.210 1.00 48.61 ? 108 VAL A CG2 1 ATOM 850 N N . ARG A 1 109 ? 62.449 14.616 5.304 1.00 48.44 ? 109 ARG A N 1 ATOM 851 C CA . ARG A 1 109 ? 61.592 14.966 6.443 1.00 48.07 ? 109 ARG A CA 1 ATOM 852 C C . ARG A 1 109 ? 61.679 16.453 6.855 1.00 52.08 ? 109 ARG A C 1 ATOM 853 O O . ARG A 1 109 ? 60.679 17.011 7.308 1.00 51.32 ? 109 ARG A O 1 ATOM 854 C CB . ARG A 1 109 ? 61.926 14.069 7.644 1.00 46.91 ? 109 ARG A CB 1 ATOM 855 C CG . ARG A 1 109 ? 61.516 12.607 7.477 1.00 49.45 ? 109 ARG A CG 1 ATOM 856 C CD . ARG A 1 109 ? 61.434 11.890 8.814 1.00 53.88 ? 109 ARG A CD 1 ATOM 857 N NE . ARG A 1 109 ? 60.390 12.465 9.675 1.00 63.88 ? 109 ARG A NE 1 ATOM 858 C CZ . ARG A 1 109 ? 59.096 12.161 9.607 1.00 69.29 ? 109 ARG A CZ 1 ATOM 859 N NH1 . ARG A 1 109 ? 58.663 11.260 8.735 1.00 62.10 ? 109 ARG A NH1 1 ATOM 860 N NH2 . ARG A 1 109 ? 58.227 12.750 10.417 1.00 39.51 ? 109 ARG A NH2 1 ATOM 861 N N . ASN A 1 110 ? 62.868 17.085 6.692 1.00 48.86 ? 110 ASN A N 1 ATOM 862 C CA . ASN A 1 110 ? 63.117 18.493 7.022 1.00 48.73 ? 110 ASN A CA 1 ATOM 863 C C . ASN A 1 110 ? 62.717 19.446 5.890 1.00 53.72 ? 110 ASN A C 1 ATOM 864 O O . ASN A 1 110 ? 62.841 20.667 6.035 1.00 55.12 ? 110 ASN A O 1 ATOM 865 C CB . ASN A 1 110 ? 64.585 18.703 7.406 1.00 48.90 ? 110 ASN A CB 1 ATOM 866 C CG . ASN A 1 110 ? 64.934 18.157 8.761 1.00 64.99 ? 110 ASN A CG 1 ATOM 867 O OD1 . ASN A 1 110 ? 64.370 18.569 9.779 1.00 65.16 ? 110 ASN A OD1 1 ATOM 868 N ND2 . ASN A 1 110 ? 65.875 17.221 8.809 1.00 49.38 ? 110 ASN A ND2 1 ATOM 869 N N . LEU A 1 111 ? 62.232 18.885 4.767 1.00 48.41 ? 111 LEU A N 1 ATOM 870 C CA . LEU A 1 111 ? 61.792 19.597 3.564 1.00 47.33 ? 111 LEU A CA 1 ATOM 871 C C . LEU A 1 111 ? 62.942 20.395 2.917 1.00 51.52 ? 111 LEU A C 1 ATOM 872 O O . LEU A 1 111 ? 62.699 21.385 2.217 1.00 52.27 ? 111 LEU A O 1 ATOM 873 C CB . LEU A 1 111 ? 60.535 20.458 3.834 1.00 47.00 ? 111 LEU A CB 1 ATOM 874 C CG . LEU A 1 111 ? 59.396 19.813 4.639 1.00 51.64 ? 111 LEU A CG 1 ATOM 875 C CD1 . LEU A 1 111 ? 58.374 20.821 5.059 1.00 51.81 ? 111 LEU A CD1 1 ATOM 876 C CD2 . LEU A 1 111 ? 58.719 18.722 3.876 1.00 54.01 ? 111 LEU A CD2 1 ATOM 877 N N . SER A 1 112 ? 64.197 19.914 3.112 1.00 46.54 ? 112 SER A N 1 ATOM 878 C CA . SER A 1 112 ? 65.419 20.531 2.599 1.00 46.22 ? 112 SER A CA 1 ATOM 879 C C . SER A 1 112 ? 65.342 20.781 1.111 1.00 50.95 ? 112 SER A C 1 ATOM 880 O O . SER A 1 112 ? 64.924 19.889 0.371 1.00 51.30 ? 112 SER A O 1 ATOM 881 C CB . SER A 1 112 ? 66.647 19.694 2.949 1.00 48.96 ? 112 SER A CB 1 ATOM 882 O OG . SER A 1 112 ? 66.956 18.725 1.964 1.00 55.58 ? 112 SER A OG 1 ATOM 883 N N . SER A 1 113 ? 65.714 22.008 0.682 1.00 47.13 ? 113 SER A N 1 ATOM 884 C CA . SER A 1 113 ? 65.681 22.470 -0.706 1.00 46.33 ? 113 SER A CA 1 ATOM 885 C C . SER A 1 113 ? 66.276 21.472 -1.691 1.00 48.21 ? 113 SER A C 1 ATOM 886 O O . SER A 1 113 ? 65.625 21.181 -2.687 1.00 47.26 ? 113 SER A O 1 ATOM 887 C CB . SER A 1 113 ? 66.360 23.825 -0.837 1.00 51.41 ? 113 SER A CB 1 ATOM 888 O OG . SER A 1 113 ? 67.743 23.726 -0.540 1.00 66.45 ? 113 SER A OG 1 ATOM 889 N N . LYS A 1 114 ? 67.471 20.902 -1.390 1.00 43.11 ? 114 LYS A N 1 ATOM 890 C CA . LYS A 1 114 ? 68.131 19.908 -2.249 1.00 42.02 ? 114 LYS A CA 1 ATOM 891 C C . LYS A 1 114 ? 67.170 18.757 -2.590 1.00 45.17 ? 114 LYS A C 1 ATOM 892 O O . LYS A 1 114 ? 66.970 18.450 -3.773 1.00 45.28 ? 114 LYS A O 1 ATOM 893 C CB . LYS A 1 114 ? 69.405 19.374 -1.575 1.00 43.34 ? 114 LYS A CB 1 ATOM 894 C CG . LYS A 1 114 ? 70.335 18.619 -2.509 1.00 48.61 ? 114 LYS A CG 1 ATOM 895 C CD . LYS A 1 114 ? 71.516 18.035 -1.734 1.00 52.59 ? 114 LYS A CD 1 ATOM 896 C CE . LYS A 1 114 ? 72.523 17.358 -2.618 1.00 58.40 ? 114 LYS A CE 1 ATOM 897 N NZ . LYS A 1 114 ? 73.792 17.074 -1.897 1.00 61.85 ? 114 LYS A NZ 1 ATOM 898 N N . ALA A 1 115 ? 66.549 18.170 -1.540 1.00 39.80 ? 115 ALA A N 1 ATOM 899 C CA . ALA A 1 115 ? 65.599 17.064 -1.621 1.00 39.12 ? 115 ALA A CA 1 ATOM 900 C C . ALA A 1 115 ? 64.326 17.464 -2.360 1.00 43.36 ? 115 ALA A C 1 ATOM 901 O O . ALA A 1 115 ? 64.001 16.828 -3.364 1.00 43.80 ? 115 ALA A O 1 ATOM 902 C CB . ALA A 1 115 ? 65.262 16.559 -0.224 1.00 39.70 ? 115 ALA A CB 1 ATOM 903 N N . VAL A 1 116 ? 63.630 18.535 -1.892 1.00 38.56 ? 116 VAL A N 1 ATOM 904 C CA . VAL A 1 116 ? 62.388 19.053 -2.489 1.00 37.76 ? 116 VAL A CA 1 ATOM 905 C C . VAL A 1 116 ? 62.574 19.414 -3.970 1.00 42.50 ? 116 VAL A C 1 ATOM 906 O O . VAL A 1 116 ? 61.684 19.114 -4.764 1.00 41.67 ? 116 VAL A O 1 ATOM 907 C CB . VAL A 1 116 ? 61.768 20.204 -1.664 1.00 40.81 ? 116 VAL A CB 1 ATOM 908 C CG1 . VAL A 1 116 ? 60.570 20.818 -2.368 1.00 39.96 ? 116 VAL A CG1 1 ATOM 909 C CG2 . VAL A 1 116 ? 61.359 19.713 -0.281 1.00 40.94 ? 116 VAL A CG2 1 ATOM 910 N N . ASN A 1 117 ? 63.750 19.988 -4.347 1.00 40.77 ? 117 ASN A N 1 ATOM 911 C CA . ASN A 1 117 ? 64.094 20.347 -5.734 1.00 40.83 ? 117 ASN A CA 1 ATOM 912 C C . ASN A 1 117 ? 64.255 19.089 -6.566 1.00 46.14 ? 117 ASN A C 1 ATOM 913 O O . ASN A 1 117 ? 63.775 19.040 -7.711 1.00 46.26 ? 117 ASN A O 1 ATOM 914 C CB . ASN A 1 117 ? 65.364 21.208 -5.816 1.00 40.66 ? 117 ASN A CB 1 ATOM 915 C CG . ASN A 1 117 ? 65.215 22.657 -5.376 1.00 61.13 ? 117 ASN A CG 1 ATOM 916 O OD1 . ASN A 1 117 ? 64.183 23.083 -4.830 1.00 46.44 ? 117 ASN A OD1 1 ATOM 917 N ND2 . ASN A 1 117 ? 66.280 23.442 -5.564 1.00 56.69 ? 117 ASN A ND2 1 ATOM 918 N N . HIS A 1 118 ? 64.882 18.049 -5.975 1.00 43.02 ? 118 HIS A N 1 ATOM 919 C CA . HIS A 1 118 ? 65.040 16.771 -6.660 1.00 42.95 ? 118 HIS A CA 1 ATOM 920 C C . HIS A 1 118 ? 63.694 16.061 -6.864 1.00 47.96 ? 118 HIS A C 1 ATOM 921 O O . HIS A 1 118 ? 63.414 15.603 -7.975 1.00 47.81 ? 118 HIS A O 1 ATOM 922 C CB . HIS A 1 118 ? 66.050 15.860 -5.963 1.00 43.21 ? 118 HIS A CB 1 ATOM 923 C CG . HIS A 1 118 ? 66.302 14.614 -6.745 1.00 46.30 ? 118 HIS A CG 1 ATOM 924 N ND1 . HIS A 1 118 ? 66.062 13.374 -6.205 1.00 47.84 ? 118 HIS A ND1 1 ATOM 925 C CD2 . HIS A 1 118 ? 66.691 14.467 -8.035 1.00 47.79 ? 118 HIS A CD2 1 ATOM 926 C CE1 . HIS A 1 118 ? 66.349 12.507 -7.159 1.00 47.41 ? 118 HIS A CE1 1 ATOM 927 N NE2 . HIS A 1 118 ? 66.741 13.123 -8.279 1.00 47.72 ? 118 HIS A NE2 1 ATOM 928 N N . ILE A 1 119 ? 62.854 16.013 -5.804 1.00 44.94 ? 119 ILE A N 1 ATOM 929 C CA . ILE A 1 119 ? 61.514 15.405 -5.817 1.00 45.23 ? 119 ILE A CA 1 ATOM 930 C C . ILE A 1 119 ? 60.640 16.054 -6.911 1.00 50.46 ? 119 ILE A C 1 ATOM 931 O O . ILE A 1 119 ? 59.919 15.352 -7.623 1.00 49.38 ? 119 ILE A O 1 ATOM 932 C CB . ILE A 1 119 ? 60.887 15.457 -4.400 1.00 48.33 ? 119 ILE A CB 1 ATOM 933 C CG1 . ILE A 1 119 ? 61.664 14.529 -3.428 1.00 48.57 ? 119 ILE A CG1 1 ATOM 934 C CG2 . ILE A 1 119 ? 59.393 15.107 -4.428 1.00 49.53 ? 119 ILE A CG2 1 ATOM 935 C CD1 . ILE A 1 119 ? 61.627 14.915 -1.946 1.00 54.26 ? 119 ILE A CD1 1 ATOM 936 N N . HIS A 1 120 ? 60.763 17.387 -7.066 1.00 48.32 ? 120 HIS A N 1 ATOM 937 C CA . HIS A 1 120 ? 60.061 18.160 -8.077 1.00 48.33 ? 120 HIS A CA 1 ATOM 938 C C . HIS A 1 120 ? 60.513 17.794 -9.503 1.00 50.52 ? 120 HIS A C 1 ATOM 939 O O . HIS A 1 120 ? 59.678 17.777 -10.409 1.00 49.15 ? 120 HIS A O 1 ATOM 940 C CB . HIS A 1 120 ? 60.192 19.662 -7.808 1.00 49.68 ? 120 HIS A CB 1 ATOM 941 C CG . HIS A 1 120 ? 59.151 20.193 -6.875 1.00 53.92 ? 120 HIS A CG 1 ATOM 942 N ND1 . HIS A 1 120 ? 59.493 20.727 -5.649 1.00 56.29 ? 120 HIS A ND1 1 ATOM 943 C CD2 . HIS A 1 120 ? 57.802 20.251 -7.011 1.00 56.09 ? 120 HIS A CD2 1 ATOM 944 C CE1 . HIS A 1 120 ? 58.354 21.103 -5.082 1.00 55.69 ? 120 HIS A CE1 1 ATOM 945 N NE2 . HIS A 1 120 ? 57.309 20.822 -5.854 1.00 55.92 ? 120 HIS A NE2 1 ATOM 946 N N . SER A 1 121 ? 61.814 17.472 -9.697 1.00 46.52 ? 121 SER A N 1 ATOM 947 C CA . SER A 1 121 ? 62.322 17.077 -11.016 1.00 46.48 ? 121 SER A CA 1 ATOM 948 C C . SER A 1 121 ? 61.895 15.632 -11.412 1.00 48.96 ? 121 SER A C 1 ATOM 949 O O . SER A 1 121 ? 61.644 15.370 -12.598 1.00 49.16 ? 121 SER A O 1 ATOM 950 C CB . SER A 1 121 ? 63.835 17.262 -11.104 1.00 50.72 ? 121 SER A CB 1 ATOM 951 O OG . SER A 1 121 ? 64.551 16.139 -10.619 1.00 63.07 ? 121 SER A OG 1 ATOM 952 N N . VAL A 1 122 ? 61.816 14.710 -10.415 1.00 41.98 ? 122 VAL A N 1 ATOM 953 C CA . VAL A 1 122 ? 61.398 13.318 -10.614 1.00 40.17 ? 122 VAL A CA 1 ATOM 954 C C . VAL A 1 122 ? 59.919 13.292 -11.031 1.00 41.64 ? 122 VAL A C 1 ATOM 955 O O . VAL A 1 122 ? 59.566 12.619 -12.005 1.00 38.91 ? 122 VAL A O 1 ATOM 956 C CB . VAL A 1 122 ? 61.687 12.429 -9.374 1.00 43.19 ? 122 VAL A CB 1 ATOM 957 C CG1 . VAL A 1 122 ? 61.159 11.009 -9.570 1.00 42.33 ? 122 VAL A CG1 1 ATOM 958 C CG2 . VAL A 1 122 ? 63.180 12.396 -9.066 1.00 43.17 ? 122 VAL A CG2 1 ATOM 959 N N . TRP A 1 123 ? 59.076 14.072 -10.316 1.00 38.65 ? 123 TRP A N 1 ATOM 960 C CA . TRP A 1 123 ? 57.650 14.218 -10.587 1.00 38.46 ? 123 TRP A CA 1 ATOM 961 C C . TRP A 1 123 ? 57.414 14.720 -12.034 1.00 43.67 ? 123 TRP A C 1 ATOM 962 O O . TRP A 1 123 ? 56.598 14.140 -12.751 1.00 44.04 ? 123 TRP A O 1 ATOM 963 C CB . TRP A 1 123 ? 57.012 15.151 -9.553 1.00 37.35 ? 123 TRP A CB 1 ATOM 964 C CG . TRP A 1 123 ? 55.518 15.236 -9.663 1.00 38.82 ? 123 TRP A CG 1 ATOM 965 C CD1 . TRP A 1 123 ? 54.794 16.252 -10.217 1.00 41.76 ? 123 TRP A CD1 1 ATOM 966 C CD2 . TRP A 1 123 ? 54.571 14.232 -9.274 1.00 38.98 ? 123 TRP A CD2 1 ATOM 967 N NE1 . TRP A 1 123 ? 53.455 15.948 -10.192 1.00 41.35 ? 123 TRP A NE1 1 ATOM 968 C CE2 . TRP A 1 123 ? 53.287 14.716 -9.609 1.00 43.07 ? 123 TRP A CE2 1 ATOM 969 C CE3 . TRP A 1 123 ? 54.682 12.951 -8.698 1.00 40.36 ? 123 TRP A CE3 1 ATOM 970 C CZ2 . TRP A 1 123 ? 52.121 13.975 -9.369 1.00 42.44 ? 123 TRP A CZ2 1 ATOM 971 C CZ3 . TRP A 1 123 ? 53.525 12.222 -8.455 1.00 41.78 ? 123 TRP A CZ3 1 ATOM 972 C CH2 . TRP A 1 123 ? 52.264 12.738 -8.776 1.00 42.40 ? 123 TRP A CH2 1 ATOM 973 N N . LYS A 1 124 ? 58.177 15.755 -12.469 1.00 39.58 ? 124 LYS A N 1 ATOM 974 C CA . LYS A 1 124 ? 58.127 16.345 -13.808 1.00 38.85 ? 124 LYS A CA 1 ATOM 975 C C . LYS A 1 124 ? 58.466 15.257 -14.818 1.00 42.44 ? 124 LYS A C 1 ATOM 976 O O . LYS A 1 124 ? 57.764 15.106 -15.820 1.00 41.92 ? 124 LYS A O 1 ATOM 977 C CB . LYS A 1 124 ? 59.143 17.501 -13.914 1.00 41.27 ? 124 LYS A CB 1 ATOM 978 C CG . LYS A 1 124 ? 58.959 18.412 -15.119 1.00 55.09 ? 124 LYS A CG 1 ATOM 979 C CD . LYS A 1 124 ? 59.801 19.687 -14.999 1.00 61.89 ? 124 LYS A CD 1 ATOM 980 C CE . LYS A 1 124 ? 59.343 20.801 -15.917 1.00 68.36 ? 124 LYS A CE 1 ATOM 981 N NZ . LYS A 1 124 ? 59.864 20.659 -17.305 1.00 66.96 ? 124 LYS A NZ 1 ATOM 982 N N . ASP A 1 125 ? 59.523 14.480 -14.528 1.00 38.91 ? 125 ASP A N 1 ATOM 983 C CA . ASP A 1 125 ? 59.982 13.366 -15.352 1.00 38.60 ? 125 ASP A CA 1 ATOM 984 C C . ASP A 1 125 ? 58.871 12.300 -15.476 1.00 43.30 ? 125 ASP A C 1 ATOM 985 O O . ASP A 1 125 ? 58.578 11.854 -16.591 1.00 43.69 ? 125 ASP A O 1 ATOM 986 C CB . ASP A 1 125 ? 61.287 12.786 -14.782 1.00 39.83 ? 125 ASP A CB 1 ATOM 987 C CG . ASP A 1 125 ? 61.869 11.645 -15.577 1.00 44.95 ? 125 ASP A CG 1 ATOM 988 O OD1 . ASP A 1 125 ? 61.407 10.514 -15.400 1.00 44.22 ? 125 ASP A OD1 1 ATOM 989 O OD2 . ASP A 1 125 ? 62.810 11.885 -16.354 1.00 52.39 ? 125 ASP A OD2 1 ATOM 990 N N . LEU A 1 126 ? 58.214 11.937 -14.355 1.00 38.09 ? 126 LEU A N 1 ATOM 991 C CA . LEU A 1 126 ? 57.116 10.967 -14.418 1.00 37.11 ? 126 LEU A CA 1 ATOM 992 C C . LEU A 1 126 ? 55.982 11.481 -15.335 1.00 40.37 ? 126 LEU A C 1 ATOM 993 O O . LEU A 1 126 ? 55.512 10.736 -16.189 1.00 39.85 ? 126 LEU A O 1 ATOM 994 C CB . LEU A 1 126 ? 56.592 10.616 -13.011 1.00 36.87 ? 126 LEU A CB 1 ATOM 995 C CG . LEU A 1 126 ? 57.568 9.859 -12.088 1.00 40.79 ? 126 LEU A CG 1 ATOM 996 C CD1 . LEU A 1 126 ? 57.064 9.819 -10.673 1.00 39.64 ? 126 LEU A CD1 1 ATOM 997 C CD2 . LEU A 1 126 ? 57.856 8.456 -12.601 1.00 44.97 ? 126 LEU A CD2 1 ATOM 998 N N . LEU A 1 127 ? 55.634 12.783 -15.228 1.00 35.70 ? 127 LEU A N 1 ATOM 999 C CA . LEU A 1 127 ? 54.589 13.411 -16.034 1.00 34.51 ? 127 LEU A CA 1 ATOM 1000 C C . LEU A 1 127 ? 54.924 13.517 -17.517 1.00 39.46 ? 127 LEU A C 1 ATOM 1001 O O . LEU A 1 127 ? 54.020 13.470 -18.351 1.00 38.89 ? 127 LEU A O 1 ATOM 1002 C CB . LEU A 1 127 ? 54.203 14.785 -15.465 1.00 33.76 ? 127 LEU A CB 1 ATOM 1003 C CG . LEU A 1 127 ? 53.569 14.805 -14.073 1.00 37.58 ? 127 LEU A CG 1 ATOM 1004 C CD1 . LEU A 1 127 ? 53.285 16.194 -13.649 1.00 37.23 ? 127 LEU A CD1 1 ATOM 1005 C CD2 . LEU A 1 127 ? 52.279 13.997 -14.009 1.00 39.95 ? 127 LEU A CD2 1 ATOM 1006 N N . GLU A 1 128 ? 56.211 13.636 -17.849 1.00 37.30 ? 128 GLU A N 1 ATOM 1007 C CA . GLU A 1 128 ? 56.658 13.783 -19.239 1.00 37.18 ? 128 GLU A CA 1 ATOM 1008 C C . GLU A 1 128 ? 57.325 12.540 -19.839 1.00 39.87 ? 128 GLU A C 1 ATOM 1009 O O . GLU A 1 128 ? 57.786 12.613 -20.972 1.00 40.26 ? 128 GLU A O 1 ATOM 1010 C CB . GLU A 1 128 ? 57.622 14.974 -19.376 1.00 38.78 ? 128 GLU A CB 1 ATOM 1011 C CG . GLU A 1 128 ? 57.135 16.299 -18.829 1.00 54.29 ? 128 GLU A CG 1 ATOM 1012 C CD . GLU A 1 128 ? 58.315 17.174 -18.482 1.00 84.47 ? 128 GLU A CD 1 ATOM 1013 O OE1 . GLU A 1 128 ? 59.297 16.643 -17.913 1.00 85.13 ? 128 GLU A OE1 1 ATOM 1014 O OE2 . GLU A 1 128 ? 58.263 18.390 -18.776 1.00 85.91 ? 128 GLU A OE2 1 ATOM 1015 N N . ASP A 1 129 ? 57.417 11.427 -19.097 1.00 35.76 ? 129 ASP A N 1 ATOM 1016 C CA . ASP A 1 129 ? 58.070 10.205 -19.576 1.00 35.25 ? 129 ASP A CA 1 ATOM 1017 C C . ASP A 1 129 ? 57.331 8.986 -19.029 1.00 38.93 ? 129 ASP A C 1 ATOM 1018 O O . ASP A 1 129 ? 57.255 8.814 -17.819 1.00 38.23 ? 129 ASP A O 1 ATOM 1019 C CB . ASP A 1 129 ? 59.540 10.211 -19.115 1.00 36.98 ? 129 ASP A CB 1 ATOM 1020 C CG . ASP A 1 129 ? 60.507 9.259 -19.785 1.00 45.32 ? 129 ASP A CG 1 ATOM 1021 O OD1 . ASP A 1 129 ? 60.065 8.195 -20.257 1.00 46.65 ? 129 ASP A OD1 1 ATOM 1022 O OD2 . ASP A 1 129 ? 61.723 9.530 -19.741 1.00 49.28 ? 129 ASP A OD2 1 ATOM 1023 N N . THR A 1 130 ? 56.749 8.161 -19.918 1.00 35.83 ? 130 THR A N 1 ATOM 1024 C CA . THR A 1 130 ? 56.000 6.957 -19.503 1.00 35.23 ? 130 THR A CA 1 ATOM 1025 C C . THR A 1 130 ? 56.588 5.641 -20.082 1.00 38.13 ? 130 THR A C 1 ATOM 1026 O O . THR A 1 130 ? 55.912 4.610 -20.006 1.00 37.97 ? 130 THR A O 1 ATOM 1027 C CB . THR A 1 130 ? 54.475 7.076 -19.858 1.00 37.72 ? 130 THR A CB 1 ATOM 1028 O OG1 . THR A 1 130 ? 54.289 6.906 -21.266 1.00 38.59 ? 130 THR A OG1 1 ATOM 1029 C CG2 . THR A 1 130 ? 53.830 8.388 -19.388 1.00 30.09 ? 130 THR A CG2 1 ATOM 1030 N N A VAL A 1 131 ? 57.815 5.688 -20.651 0.50 34.12 ? 131 VAL A N 1 ATOM 1031 N N B VAL A 1 131 ? 57.822 5.671 -20.647 0.50 33.75 ? 131 VAL A N 1 ATOM 1032 C CA A VAL A 1 131 ? 58.461 4.536 -21.291 0.50 33.92 ? 131 VAL A CA 1 ATOM 1033 C CA B VAL A 1 131 ? 58.446 4.493 -21.271 0.50 33.36 ? 131 VAL A CA 1 ATOM 1034 C C A VAL A 1 131 ? 59.772 4.104 -20.608 0.50 38.83 ? 131 VAL A C 1 ATOM 1035 C C B VAL A 1 131 ? 59.811 4.096 -20.665 0.50 38.57 ? 131 VAL A C 1 ATOM 1036 O O A VAL A 1 131 ? 60.018 2.903 -20.496 0.50 38.78 ? 131 VAL A O 1 ATOM 1037 O O B VAL A 1 131 ? 60.129 2.906 -20.666 0.50 38.49 ? 131 VAL A O 1 ATOM 1038 C CB A VAL A 1 131 ? 58.681 4.750 -22.821 0.50 37.52 ? 131 VAL A CB 1 ATOM 1039 C CB B VAL A 1 131 ? 58.545 4.602 -22.817 0.50 36.65 ? 131 VAL A CB 1 ATOM 1040 C CG1 A VAL A 1 131 ? 58.842 3.416 -23.539 0.50 37.26 ? 131 VAL A CG1 1 ATOM 1041 C CG1 B VAL A 1 131 ? 57.172 4.465 -23.468 0.50 36.61 ? 131 VAL A CG1 1 ATOM 1042 C CG2 A VAL A 1 131 ? 57.549 5.556 -23.460 0.50 37.43 ? 131 VAL A CG2 1 ATOM 1043 C CG2 B VAL A 1 131 ? 59.240 5.888 -23.261 0.50 36.20 ? 131 VAL A CG2 1 ATOM 1044 N N . THR A 1 132 ? 60.623 5.065 -20.193 1.00 35.44 ? 132 THR A N 1 ATOM 1045 C CA . THR A 1 132 ? 61.956 4.786 -19.609 1.00 34.97 ? 132 THR A CA 1 ATOM 1046 C C . THR A 1 132 ? 61.932 3.996 -18.315 1.00 39.16 ? 132 THR A C 1 ATOM 1047 O O . THR A 1 132 ? 61.510 4.574 -17.314 1.00 38.73 ? 132 THR A O 1 ATOM 1048 C CB . THR A 1 132 ? 62.781 6.062 -19.396 1.00 36.29 ? 132 THR A CB 1 ATOM 1049 O OG1 . THR A 1 132 ? 62.480 7.016 -20.409 1.00 36.39 ? 132 THR A OG1 1 ATOM 1050 C CG2 . THR A 1 132 ? 64.270 5.775 -19.363 1.00 30.60 ? 132 THR A CG2 1 ATOM 1051 N N . PRO A 1 133 ? 62.450 2.731 -18.263 1.00 35.79 ? 133 PRO A N 1 ATOM 1052 C CA . PRO A 1 133 ? 62.452 1.998 -16.979 1.00 35.40 ? 133 PRO A CA 1 ATOM 1053 C C . PRO A 1 133 ? 63.233 2.726 -15.888 1.00 38.16 ? 133 PRO A C 1 ATOM 1054 O O . PRO A 1 133 ? 64.319 3.272 -16.137 1.00 39.59 ? 133 PRO A O 1 ATOM 1055 C CB . PRO A 1 133 ? 63.057 0.635 -17.339 1.00 37.20 ? 133 PRO A CB 1 ATOM 1056 C CG . PRO A 1 133 ? 62.850 0.507 -18.811 1.00 41.07 ? 133 PRO A CG 1 ATOM 1057 C CD . PRO A 1 133 ? 63.018 1.895 -19.339 1.00 36.71 ? 133 PRO A CD 1 ATOM 1058 N N . ILE A 1 134 ? 62.615 2.822 -14.702 1.00 30.94 ? 134 ILE A N 1 ATOM 1059 C CA . ILE A 1 134 ? 63.198 3.486 -13.536 1.00 28.16 ? 134 ILE A CA 1 ATOM 1060 C C . ILE A 1 134 ? 64.181 2.518 -12.877 1.00 32.96 ? 134 ILE A C 1 ATOM 1061 O O . ILE A 1 134 ? 63.849 1.345 -12.653 1.00 32.18 ? 134 ILE A O 1 ATOM 1062 C CB . ILE A 1 134 ? 62.079 4.006 -12.572 1.00 28.96 ? 134 ILE A CB 1 ATOM 1063 C CG1 . ILE A 1 134 ? 61.334 5.204 -13.202 1.00 27.86 ? 134 ILE A CG1 1 ATOM 1064 C CG2 . ILE A 1 134 ? 62.623 4.367 -11.180 1.00 27.42 ? 134 ILE A CG2 1 ATOM 1065 C CD1 . ILE A 1 134 ? 59.956 5.430 -12.743 1.00 26.88 ? 134 ILE A CD1 1 ATOM 1066 N N . ASP A 1 135 ? 65.395 3.011 -12.586 1.00 30.67 ? 135 ASP A N 1 ATOM 1067 C CA . ASP A 1 135 ? 66.434 2.227 -11.927 1.00 30.61 ? 135 ASP A CA 1 ATOM 1068 C C . ASP A 1 135 ? 66.026 1.876 -10.495 1.00 35.70 ? 135 ASP A C 1 ATOM 1069 O O . ASP A 1 135 ? 65.499 2.726 -9.772 1.00 35.73 ? 135 ASP A O 1 ATOM 1070 C CB . ASP A 1 135 ? 67.773 2.977 -11.916 1.00 31.95 ? 135 ASP A CB 1 ATOM 1071 C CG . ASP A 1 135 ? 68.853 2.210 -11.177 1.00 43.56 ? 135 ASP A CG 1 ATOM 1072 O OD1 . ASP A 1 135 ? 69.171 1.074 -11.601 1.00 43.03 ? 135 ASP A OD1 1 ATOM 1073 O OD2 . ASP A 1 135 ? 69.289 2.687 -10.104 1.00 52.36 ? 135 ASP A OD2 1 ATOM 1074 N N . THR A 1 136 ? 66.271 0.616 -10.101 1.00 31.95 ? 136 THR A N 1 ATOM 1075 C CA . THR A 1 136 ? 65.962 0.097 -8.772 1.00 31.51 ? 136 THR A CA 1 ATOM 1076 C C . THR A 1 136 ? 67.226 -0.467 -8.134 1.00 34.81 ? 136 THR A C 1 ATOM 1077 O O . THR A 1 136 ? 68.205 -0.718 -8.826 1.00 33.68 ? 136 THR A O 1 ATOM 1078 C CB . THR A 1 136 ? 64.834 -0.961 -8.841 1.00 39.96 ? 136 THR A CB 1 ATOM 1079 O OG1 . THR A 1 136 ? 65.320 -2.136 -9.478 1.00 41.95 ? 136 THR A OG1 1 ATOM 1080 C CG2 . THR A 1 136 ? 63.610 -0.478 -9.582 1.00 38.54 ? 136 THR A CG2 1 ATOM 1081 N N . THR A 1 137 ? 67.193 -0.711 -6.830 1.00 32.57 ? 137 THR A N 1 ATOM 1082 C CA . THR A 1 137 ? 68.332 -1.285 -6.134 1.00 32.89 ? 137 THR A CA 1 ATOM 1083 C C . THR A 1 137 ? 67.975 -2.668 -5.584 1.00 38.35 ? 137 THR A C 1 ATOM 1084 O O . THR A 1 137 ? 66.947 -2.816 -4.933 1.00 38.39 ? 137 THR A O 1 ATOM 1085 C CB . THR A 1 137 ? 68.866 -0.280 -5.106 1.00 37.04 ? 137 THR A CB 1 ATOM 1086 O OG1 . THR A 1 137 ? 69.383 0.832 -5.840 1.00 39.64 ? 137 THR A OG1 1 ATOM 1087 C CG2 . THR A 1 137 ? 69.957 -0.864 -4.179 1.00 28.21 ? 137 THR A CG2 1 ATOM 1088 N N . ILE A 1 138 ? 68.791 -3.681 -5.898 1.00 35.49 ? 138 ILE A N 1 ATOM 1089 C CA . ILE A 1 138 ? 68.591 -5.029 -5.386 1.00 36.53 ? 138 ILE A CA 1 ATOM 1090 C C . ILE A 1 138 ? 69.495 -5.214 -4.174 1.00 45.46 ? 138 ILE A C 1 ATOM 1091 O O . ILE A 1 138 ? 70.682 -4.883 -4.237 1.00 44.34 ? 138 ILE A O 1 ATOM 1092 C CB . ILE A 1 138 ? 68.682 -6.160 -6.448 1.00 39.47 ? 138 ILE A CB 1 ATOM 1093 C CG1 . ILE A 1 138 ? 68.248 -7.511 -5.842 1.00 39.87 ? 138 ILE A CG1 1 ATOM 1094 C CG2 . ILE A 1 138 ? 70.060 -6.230 -7.136 1.00 40.39 ? 138 ILE A CG2 1 ATOM 1095 C CD1 . ILE A 1 138 ? 67.480 -8.388 -6.734 1.00 48.98 ? 138 ILE A CD1 1 ATOM 1096 N N . MET A 1 139 ? 68.902 -5.659 -3.042 1.00 45.65 ? 139 MET A N 1 ATOM 1097 C CA . MET A 1 139 ? 69.597 -5.833 -1.766 1.00 45.89 ? 139 MET A CA 1 ATOM 1098 C C . MET A 1 139 ? 69.098 -7.033 -0.995 1.00 48.24 ? 139 MET A C 1 ATOM 1099 O O . MET A 1 139 ? 67.898 -7.301 -0.975 1.00 46.65 ? 139 MET A O 1 ATOM 1100 C CB . MET A 1 139 ? 69.438 -4.584 -0.887 1.00 48.61 ? 139 MET A CB 1 ATOM 1101 C CG . MET A 1 139 ? 70.303 -3.446 -1.312 1.00 53.48 ? 139 MET A CG 1 ATOM 1102 S SD . MET A 1 139 ? 71.166 -2.603 0.036 1.00 59.32 ? 139 MET A SD 1 ATOM 1103 C CE . MET A 1 139 ? 72.004 -3.984 0.851 1.00 56.03 ? 139 MET A CE 1 ATOM 1104 N N . ALA A 1 140 ? 70.018 -7.722 -0.302 1.00 44.31 ? 140 ALA A N 1 ATOM 1105 C CA . ALA A 1 140 ? 69.649 -8.836 0.552 1.00 43.25 ? 140 ALA A CA 1 ATOM 1106 C C . ALA A 1 140 ? 69.262 -8.260 1.908 1.00 46.31 ? 140 ALA A C 1 ATOM 1107 O O . ALA A 1 140 ? 69.972 -7.397 2.438 1.00 46.37 ? 140 ALA A O 1 ATOM 1108 C CB . ALA A 1 140 ? 70.802 -9.807 0.691 1.00 43.75 ? 140 ALA A CB 1 ATOM 1109 N N . LYS A 1 141 ? 68.093 -8.679 2.430 1.00 41.53 ? 141 LYS A N 1 ATOM 1110 C CA . LYS A 1 141 ? 67.583 -8.249 3.732 1.00 40.84 ? 141 LYS A CA 1 ATOM 1111 C C . LYS A 1 141 ? 68.399 -8.906 4.821 1.00 46.90 ? 141 LYS A C 1 ATOM 1112 O O . LYS A 1 141 ? 68.903 -10.013 4.621 1.00 47.71 ? 141 LYS A O 1 ATOM 1113 C CB . LYS A 1 141 ? 66.118 -8.652 3.908 1.00 42.27 ? 141 LYS A CB 1 ATOM 1114 C CG . LYS A 1 141 ? 65.132 -7.764 3.176 1.00 58.46 ? 141 LYS A CG 1 ATOM 1115 C CD . LYS A 1 141 ? 63.709 -8.073 3.614 1.00 71.14 ? 141 LYS A CD 1 ATOM 1116 C CE . LYS A 1 141 ? 62.672 -7.401 2.748 1.00 86.95 ? 141 LYS A CE 1 ATOM 1117 N NZ . LYS A 1 141 ? 62.581 -8.011 1.392 1.00 94.82 ? 141 LYS A NZ 1 ATOM 1118 N N . ASN A 1 142 ? 68.543 -8.233 5.966 1.00 43.69 ? 142 ASN A N 1 ATOM 1119 C CA . ASN A 1 142 ? 69.240 -8.804 7.115 1.00 43.45 ? 142 ASN A CA 1 ATOM 1120 C C . ASN A 1 142 ? 68.170 -9.082 8.154 1.00 46.79 ? 142 ASN A C 1 ATOM 1121 O O . ASN A 1 142 ? 67.795 -8.173 8.907 1.00 46.10 ? 142 ASN A O 1 ATOM 1122 C CB . ASN A 1 142 ? 70.323 -7.863 7.667 1.00 45.82 ? 142 ASN A CB 1 ATOM 1123 C CG . ASN A 1 142 ? 71.508 -7.624 6.764 1.00 66.50 ? 142 ASN A CG 1 ATOM 1124 O OD1 . ASN A 1 142 ? 71.964 -6.489 6.604 1.00 62.11 ? 142 ASN A OD1 1 ATOM 1125 N ND2 . ASN A 1 142 ? 72.074 -8.681 6.203 1.00 58.18 ? 142 ASN A ND2 1 ATOM 1126 N N . GLU A 1 143 ? 67.619 -10.325 8.131 1.00 42.80 ? 143 GLU A N 1 ATOM 1127 C CA . GLU A 1 143 ? 66.565 -10.782 9.044 1.00 42.27 ? 143 GLU A CA 1 ATOM 1128 C C . GLU A 1 143 ? 67.040 -11.909 9.943 1.00 46.26 ? 143 GLU A C 1 ATOM 1129 O O . GLU A 1 143 ? 67.842 -12.742 9.527 1.00 45.79 ? 143 GLU A O 1 ATOM 1130 C CB . GLU A 1 143 ? 65.311 -11.194 8.269 1.00 43.76 ? 143 GLU A CB 1 ATOM 1131 C CG . GLU A 1 143 ? 64.570 -10.015 7.655 1.00 53.47 ? 143 GLU A CG 1 ATOM 1132 C CD . GLU A 1 143 ? 63.491 -10.355 6.649 1.00 72.29 ? 143 GLU A CD 1 ATOM 1133 O OE1 . GLU A 1 143 ? 63.696 -11.275 5.822 1.00 62.69 ? 143 GLU A OE1 1 ATOM 1134 O OE2 . GLU A 1 143 ? 62.452 -9.658 6.660 1.00 71.79 ? 143 GLU A OE2 1 ATOM 1135 N N . VAL A 1 144 ? 66.531 -11.939 11.177 1.00 43.30 ? 144 VAL A N 1 ATOM 1136 C CA . VAL A 1 144 ? 66.909 -12.926 12.194 1.00 42.84 ? 144 VAL A CA 1 ATOM 1137 C C . VAL A 1 144 ? 65.916 -14.110 12.276 1.00 45.24 ? 144 VAL A C 1 ATOM 1138 O O . VAL A 1 144 ? 64.707 -13.909 12.370 1.00 43.01 ? 144 VAL A O 1 ATOM 1139 C CB . VAL A 1 144 ? 67.127 -12.237 13.574 1.00 46.62 ? 144 VAL A CB 1 ATOM 1140 C CG1 . VAL A 1 144 ? 67.613 -13.222 14.630 1.00 46.67 ? 144 VAL A CG1 1 ATOM 1141 C CG2 . VAL A 1 144 ? 68.089 -11.062 13.461 1.00 46.30 ? 144 VAL A CG2 1 ATOM 1142 N N . PHE A 1 145 ? 66.454 -15.346 12.258 1.00 42.56 ? 145 PHE A N 1 ATOM 1143 C CA . PHE A 1 145 ? 65.687 -16.590 12.391 1.00 41.82 ? 145 PHE A CA 1 ATOM 1144 C C . PHE A 1 145 ? 66.384 -17.618 13.312 1.00 46.41 ? 145 PHE A C 1 ATOM 1145 O O . PHE A 1 145 ? 67.559 -17.460 13.662 1.00 47.04 ? 145 PHE A O 1 ATOM 1146 C CB . PHE A 1 145 ? 65.408 -17.234 11.015 1.00 43.02 ? 145 PHE A CB 1 ATOM 1147 C CG . PHE A 1 145 ? 64.844 -16.325 9.959 1.00 43.99 ? 145 PHE A CG 1 ATOM 1148 C CD1 . PHE A 1 145 ? 63.494 -16.012 9.940 1.00 46.66 ? 145 PHE A CD1 1 ATOM 1149 C CD2 . PHE A 1 145 ? 65.666 -15.787 8.972 1.00 46.43 ? 145 PHE A CD2 1 ATOM 1150 C CE1 . PHE A 1 145 ? 62.974 -15.154 8.962 1.00 48.13 ? 145 PHE A CE1 1 ATOM 1151 C CE2 . PHE A 1 145 ? 65.151 -14.927 7.999 1.00 49.12 ? 145 PHE A CE2 1 ATOM 1152 C CZ . PHE A 1 145 ? 63.807 -14.615 8.001 1.00 47.33 ? 145 PHE A CZ 1 ATOM 1153 N N . CYS A 1 146 ? 65.638 -18.672 13.691 1.00 41.88 ? 146 CYS A N 1 ATOM 1154 C CA . CYS A 1 146 ? 66.096 -19.834 14.448 1.00 41.28 ? 146 CYS A CA 1 ATOM 1155 C C . CYS A 1 146 ? 66.369 -20.923 13.382 1.00 48.63 ? 146 CYS A C 1 ATOM 1156 O O . CYS A 1 146 ? 65.791 -20.855 12.286 1.00 48.82 ? 146 CYS A O 1 ATOM 1157 C CB . CYS A 1 146 ? 65.014 -20.270 15.435 1.00 40.52 ? 146 CYS A CB 1 ATOM 1158 S SG . CYS A 1 146 ? 65.451 -21.696 16.468 1.00 43.77 ? 146 CYS A SG 1 ATOM 1159 N N . VAL A 1 147 ? 67.237 -21.912 13.666 1.00 46.74 ? 147 VAL A N 1 ATOM 1160 C CA . VAL A 1 147 ? 67.501 -22.942 12.646 1.00 46.99 ? 147 VAL A CA 1 ATOM 1161 C C . VAL A 1 147 ? 66.337 -23.960 12.555 1.00 53.07 ? 147 VAL A C 1 ATOM 1162 O O . VAL A 1 147 ? 65.764 -24.347 13.582 1.00 53.28 ? 147 VAL A O 1 ATOM 1163 C CB . VAL A 1 147 ? 68.889 -23.637 12.739 1.00 50.11 ? 147 VAL A CB 1 ATOM 1164 C CG1 . VAL A 1 147 ? 70.026 -22.637 12.578 1.00 49.97 ? 147 VAL A CG1 1 ATOM 1165 C CG2 . VAL A 1 147 ? 69.050 -24.432 14.017 1.00 49.55 ? 147 VAL A CG2 1 ATOM 1166 N N . GLN A 1 148 ? 65.986 -24.359 11.306 1.00 50.33 ? 148 GLN A N 1 ATOM 1167 C CA . GLN A 1 148 ? 64.922 -25.315 10.942 1.00 75.53 ? 148 GLN A CA 1 ATOM 1168 C C . GLN A 1 148 ? 63.566 -24.949 11.554 1.00 109.62 ? 148 GLN A C 1 ATOM 1169 O O . GLN A 1 148 ? 63.029 -23.882 11.261 1.00 73.35 ? 148 GLN A O 1 ATOM 1170 C CB . GLN A 1 148 ? 65.322 -26.779 11.260 1.00 76.77 ? 148 GLN A CB 1 ATOM 1171 C CG . GLN A 1 148 ? 64.368 -27.848 10.700 1.00 89.55 ? 148 GLN A CG 1 ATOM 1172 C CD . GLN A 1 148 ? 65.027 -28.838 9.755 1.00 101.54 ? 148 GLN A CD 1 ATOM 1173 O OE1 . GLN A 1 148 ? 66.037 -29.483 10.075 1.00 93.97 ? 148 GLN A OE1 1 ATOM 1174 N NE2 . GLN A 1 148 ? 64.419 -29.034 8.588 1.00 91.51 ? 148 GLN A NE2 1 ATOM 1175 N N . ARG A 1 154 ? 68.513 -23.310 7.759 1.00 55.98 ? 154 ARG A N 1 ATOM 1176 C CA . ARG A 1 154 ? 68.972 -21.954 7.440 1.00 55.57 ? 154 ARG A CA 1 ATOM 1177 C C . ARG A 1 154 ? 68.411 -21.428 6.113 1.00 58.38 ? 154 ARG A C 1 ATOM 1178 O O . ARG A 1 154 ? 68.795 -21.900 5.041 1.00 59.23 ? 154 ARG A O 1 ATOM 1179 C CB . ARG A 1 154 ? 70.505 -21.867 7.480 1.00 55.93 ? 154 ARG A CB 1 ATOM 1180 C CG . ARG A 1 154 ? 71.054 -21.153 8.719 1.00 64.94 ? 154 ARG A CG 1 ATOM 1181 C CD . ARG A 1 154 ? 72.535 -21.399 8.928 1.00 77.02 ? 154 ARG A CD 1 ATOM 1182 N NE . ARG A 1 154 ? 73.349 -20.209 8.649 1.00 91.53 ? 154 ARG A NE 1 ATOM 1183 C CZ . ARG A 1 154 ? 74.069 -19.558 9.561 1.00 108.21 ? 154 ARG A CZ 1 ATOM 1184 N NH1 . ARG A 1 154 ? 74.104 -19.981 10.817 1.00 96.94 ? 154 ARG A NH1 1 ATOM 1185 N NH2 . ARG A 1 154 ? 74.765 -18.481 9.220 1.00 94.00 ? 154 ARG A NH2 1 ATOM 1186 N N . LYS A 1 155 ? 67.514 -20.433 6.198 1.00 52.78 ? 155 LYS A N 1 ATOM 1187 C CA . LYS A 1 155 ? 66.855 -19.765 5.065 1.00 51.58 ? 155 LYS A CA 1 ATOM 1188 C C . LYS A 1 155 ? 67.809 -18.841 4.272 1.00 54.66 ? 155 LYS A C 1 ATOM 1189 O O . LYS A 1 155 ? 68.562 -18.090 4.903 1.00 53.37 ? 155 LYS A O 1 ATOM 1190 C CB . LYS A 1 155 ? 65.673 -18.901 5.572 1.00 52.90 ? 155 LYS A CB 1 ATOM 1191 C CG . LYS A 1 155 ? 64.558 -19.680 6.255 1.00 60.01 ? 155 LYS A CG 1 ATOM 1192 C CD . LYS A 1 155 ? 63.481 -18.774 6.843 1.00 63.79 ? 155 LYS A CD 1 ATOM 1193 C CE . LYS A 1 155 ? 62.352 -19.592 7.435 1.00 66.35 ? 155 LYS A CE 1 ATOM 1194 N NZ . LYS A 1 155 ? 61.396 -18.758 8.201 1.00 69.91 ? 155 LYS A NZ 1 ATOM 1195 N N . PRO A 1 156 ? 67.748 -18.796 2.904 1.00 50.90 ? 156 PRO A N 1 ATOM 1196 C CA . PRO A 1 156 ? 68.558 -17.795 2.183 1.00 49.52 ? 156 PRO A CA 1 ATOM 1197 C C . PRO A 1 156 ? 67.910 -16.413 2.354 1.00 52.02 ? 156 PRO A C 1 ATOM 1198 O O . PRO A 1 156 ? 66.690 -16.332 2.559 1.00 50.55 ? 156 PRO A O 1 ATOM 1199 C CB . PRO A 1 156 ? 68.535 -18.274 0.724 1.00 50.83 ? 156 PRO A CB 1 ATOM 1200 C CG . PRO A 1 156 ? 67.350 -19.119 0.601 1.00 55.54 ? 156 PRO A CG 1 ATOM 1201 C CD . PRO A 1 156 ? 66.896 -19.570 1.973 1.00 52.05 ? 156 PRO A CD 1 ATOM 1202 N N . ALA A 1 157 ? 68.729 -15.337 2.299 1.00 47.99 ? 157 ALA A N 1 ATOM 1203 C CA . ALA A 1 157 ? 68.313 -13.941 2.464 1.00 46.95 ? 157 ALA A CA 1 ATOM 1204 C C . ALA A 1 157 ? 67.209 -13.521 1.514 1.00 48.76 ? 157 ALA A C 1 ATOM 1205 O O . ALA A 1 157 ? 67.299 -13.788 0.319 1.00 47.89 ? 157 ALA A O 1 ATOM 1206 C CB . ALA A 1 157 ? 69.507 -13.025 2.284 1.00 47.72 ? 157 ALA A CB 1 ATOM 1207 N N . ARG A 1 158 ? 66.176 -12.845 2.046 1.00 44.27 ? 158 ARG A N 1 ATOM 1208 C CA . ARG A 1 158 ? 65.055 -12.324 1.256 1.00 43.44 ? 158 ARG A CA 1 ATOM 1209 C C . ARG A 1 158 ? 65.546 -11.105 0.488 1.00 43.99 ? 158 ARG A C 1 ATOM 1210 O O . ARG A 1 158 ? 66.448 -10.416 0.958 1.00 43.48 ? 158 ARG A O 1 ATOM 1211 C CB . ARG A 1 158 ? 63.882 -11.931 2.165 1.00 44.99 ? 158 ARG A CB 1 ATOM 1212 C CG . ARG A 1 158 ? 62.970 -13.084 2.539 1.00 57.69 ? 158 ARG A CG 1 ATOM 1213 C CD . ARG A 1 158 ? 61.516 -12.642 2.536 1.00 80.91 ? 158 ARG A CD 1 ATOM 1214 N NE . ARG A 1 158 ? 61.152 -11.826 3.702 1.00 100.19 ? 158 ARG A NE 1 ATOM 1215 C CZ . ARG A 1 158 ? 60.151 -10.946 3.725 1.00 120.41 ? 158 ARG A CZ 1 ATOM 1216 N NH1 . ARG A 1 158 ? 59.414 -10.737 2.640 1.00 109.58 ? 158 ARG A NH1 1 ATOM 1217 N NH2 . ARG A 1 158 ? 59.887 -10.261 4.831 1.00 109.32 ? 158 ARG A NH2 1 ATOM 1218 N N . LEU A 1 159 ? 64.975 -10.832 -0.675 1.00 38.72 ? 159 LEU A N 1 ATOM 1219 C CA . LEU A 1 159 ? 65.424 -9.706 -1.488 1.00 37.96 ? 159 LEU A CA 1 ATOM 1220 C C . LEU A 1 159 ? 64.516 -8.471 -1.369 1.00 43.04 ? 159 LEU A C 1 ATOM 1221 O O . LEU A 1 159 ? 63.293 -8.605 -1.239 1.00 43.48 ? 159 LEU A O 1 ATOM 1222 C CB . LEU A 1 159 ? 65.555 -10.153 -2.955 1.00 37.64 ? 159 LEU A CB 1 ATOM 1223 C CG . LEU A 1 159 ? 66.904 -10.663 -3.483 1.00 41.96 ? 159 LEU A CG 1 ATOM 1224 C CD1 . LEU A 1 159 ? 67.765 -11.320 -2.409 1.00 42.58 ? 159 LEU A CD1 1 ATOM 1225 C CD2 . LEU A 1 159 ? 66.702 -11.596 -4.647 1.00 42.95 ? 159 LEU A CD2 1 ATOM 1226 N N . ILE A 1 160 ? 65.136 -7.267 -1.388 1.00 37.98 ? 160 ILE A N 1 ATOM 1227 C CA . ILE A 1 160 ? 64.461 -5.974 -1.357 1.00 36.25 ? 160 ILE A CA 1 ATOM 1228 C C . ILE A 1 160 ? 64.862 -5.198 -2.630 1.00 38.57 ? 160 ILE A C 1 ATOM 1229 O O . ILE A 1 160 ? 66.046 -5.025 -2.926 1.00 38.00 ? 160 ILE A O 1 ATOM 1230 C CB . ILE A 1 160 ? 64.599 -5.189 -0.002 1.00 39.07 ? 160 ILE A CB 1 ATOM 1231 C CG1 . ILE A 1 160 ? 63.711 -3.916 0.052 1.00 39.18 ? 160 ILE A CG1 1 ATOM 1232 C CG2 . ILE A 1 160 ? 66.028 -4.860 0.378 1.00 39.64 ? 160 ILE A CG2 1 ATOM 1233 C CD1 . ILE A 1 160 ? 62.278 -4.137 0.528 1.00 39.33 ? 160 ILE A CD1 1 ATOM 1234 N N . VAL A 1 161 ? 63.857 -4.847 -3.436 1.00 33.93 ? 161 VAL A N 1 ATOM 1235 C CA . VAL A 1 161 ? 64.026 -4.123 -4.693 1.00 32.63 ? 161 VAL A CA 1 ATOM 1236 C C . VAL A 1 161 ? 63.290 -2.798 -4.502 1.00 35.12 ? 161 VAL A C 1 ATOM 1237 O O . VAL A 1 161 ? 62.074 -2.785 -4.318 1.00 33.12 ? 161 VAL A O 1 ATOM 1238 C CB . VAL A 1 161 ? 63.538 -4.922 -5.948 1.00 35.79 ? 161 VAL A CB 1 ATOM 1239 C CG1 . VAL A 1 161 ? 63.660 -4.092 -7.225 1.00 35.23 ? 161 VAL A CG1 1 ATOM 1240 C CG2 . VAL A 1 161 ? 64.285 -6.244 -6.098 1.00 35.35 ? 161 VAL A CG2 1 ATOM 1241 N N . PHE A 1 162 ? 64.034 -1.684 -4.536 1.00 31.63 ? 162 PHE A N 1 ATOM 1242 C CA . PHE A 1 162 ? 63.461 -0.369 -4.306 1.00 30.10 ? 162 PHE A CA 1 ATOM 1243 C C . PHE A 1 162 ? 63.954 0.713 -5.255 1.00 36.57 ? 162 PHE A C 1 ATOM 1244 O O . PHE A 1 162 ? 65.136 0.731 -5.587 1.00 35.97 ? 162 PHE A O 1 ATOM 1245 C CB . PHE A 1 162 ? 63.705 0.046 -2.848 1.00 30.45 ? 162 PHE A CB 1 ATOM 1246 C CG . PHE A 1 162 ? 65.145 0.046 -2.390 1.00 30.05 ? 162 PHE A CG 1 ATOM 1247 C CD1 . PHE A 1 162 ? 65.728 -1.104 -1.882 1.00 31.15 ? 162 PHE A CD1 1 ATOM 1248 C CD2 . PHE A 1 162 ? 65.895 1.218 -2.398 1.00 30.34 ? 162 PHE A CD2 1 ATOM 1249 C CE1 . PHE A 1 162 ? 67.038 -1.091 -1.421 1.00 31.21 ? 162 PHE A CE1 1 ATOM 1250 C CE2 . PHE A 1 162 ? 67.204 1.230 -1.939 1.00 31.77 ? 162 PHE A CE2 1 ATOM 1251 C CZ . PHE A 1 162 ? 67.763 0.079 -1.440 1.00 29.82 ? 162 PHE A CZ 1 ATOM 1252 N N . PRO A 1 163 ? 63.086 1.676 -5.650 1.00 35.89 ? 163 PRO A N 1 ATOM 1253 C CA . PRO A 1 163 ? 63.573 2.792 -6.465 1.00 36.18 ? 163 PRO A CA 1 ATOM 1254 C C . PRO A 1 163 ? 64.209 3.846 -5.545 1.00 41.23 ? 163 PRO A C 1 ATOM 1255 O O . PRO A 1 163 ? 64.125 3.725 -4.310 1.00 41.19 ? 163 PRO A O 1 ATOM 1256 C CB . PRO A 1 163 ? 62.295 3.314 -7.115 1.00 37.95 ? 163 PRO A CB 1 ATOM 1257 C CG . PRO A 1 163 ? 61.243 3.061 -6.101 1.00 42.13 ? 163 PRO A CG 1 ATOM 1258 C CD . PRO A 1 163 ? 61.653 1.849 -5.314 1.00 37.81 ? 163 PRO A CD 1 ATOM 1259 N N . ASP A 1 164 ? 64.819 4.892 -6.134 1.00 37.07 ? 164 ASP A N 1 ATOM 1260 C CA . ASP A 1 164 ? 65.456 5.974 -5.385 1.00 36.34 ? 164 ASP A CA 1 ATOM 1261 C C . ASP A 1 164 ? 64.468 6.696 -4.490 1.00 40.00 ? 164 ASP A C 1 ATOM 1262 O O . ASP A 1 164 ? 63.302 6.836 -4.852 1.00 40.17 ? 164 ASP A O 1 ATOM 1263 C CB . ASP A 1 164 ? 66.111 6.975 -6.340 1.00 37.91 ? 164 ASP A CB 1 ATOM 1264 C CG . ASP A 1 164 ? 66.995 7.956 -5.626 1.00 44.20 ? 164 ASP A CG 1 ATOM 1265 O OD1 . ASP A 1 164 ? 68.089 7.538 -5.161 1.00 45.96 ? 164 ASP A OD1 1 ATOM 1266 O OD2 . ASP A 1 164 ? 66.554 9.110 -5.429 1.00 43.68 ? 164 ASP A OD2 1 ATOM 1267 N N . LEU A 1 165 ? 64.940 7.170 -3.335 1.00 36.34 ? 165 LEU A N 1 ATOM 1268 C CA . LEU A 1 165 ? 64.159 7.910 -2.346 1.00 35.76 ? 165 LEU A CA 1 ATOM 1269 C C . LEU A 1 165 ? 63.295 9.013 -2.976 1.00 39.03 ? 165 LEU A C 1 ATOM 1270 O O . LEU A 1 165 ? 62.143 9.197 -2.564 1.00 37.97 ? 165 LEU A O 1 ATOM 1271 C CB . LEU A 1 165 ? 65.113 8.452 -1.264 1.00 35.40 ? 165 LEU A CB 1 ATOM 1272 C CG . LEU A 1 165 ? 64.620 9.480 -0.254 1.00 39.53 ? 165 LEU A CG 1 ATOM 1273 C CD1 . LEU A 1 165 ? 63.591 8.894 0.694 1.00 39.06 ? 165 LEU A CD1 1 ATOM 1274 C CD2 . LEU A 1 165 ? 65.777 9.999 0.534 1.00 43.16 ? 165 LEU A CD2 1 ATOM 1275 N N . GLY A 1 166 ? 63.853 9.698 -3.979 1.00 34.33 ? 166 GLY A N 1 ATOM 1276 C CA . GLY A 1 166 ? 63.160 10.755 -4.706 1.00 33.57 ? 166 GLY A CA 1 ATOM 1277 C C . GLY A 1 166 ? 61.906 10.271 -5.399 1.00 36.33 ? 166 GLY A C 1 ATOM 1278 O O . GLY A 1 166 ? 60.883 10.949 -5.337 1.00 35.94 ? 166 GLY A O 1 ATOM 1279 N N . VAL A 1 167 ? 61.980 9.077 -6.043 1.00 33.12 ? 167 VAL A N 1 ATOM 1280 C CA . VAL A 1 167 ? 60.879 8.386 -6.741 1.00 32.87 ? 167 VAL A CA 1 ATOM 1281 C C . VAL A 1 167 ? 59.842 7.953 -5.706 1.00 36.94 ? 167 VAL A C 1 ATOM 1282 O O . VAL A 1 167 ? 58.645 8.001 -5.976 1.00 36.09 ? 167 VAL A O 1 ATOM 1283 C CB . VAL A 1 167 ? 61.395 7.156 -7.550 1.00 36.48 ? 167 VAL A CB 1 ATOM 1284 C CG1 . VAL A 1 167 ? 60.253 6.392 -8.218 1.00 35.65 ? 167 VAL A CG1 1 ATOM 1285 C CG2 . VAL A 1 167 ? 62.442 7.569 -8.574 1.00 36.46 ? 167 VAL A CG2 1 ATOM 1286 N N . ARG A 1 168 ? 60.318 7.511 -4.528 1.00 34.52 ? 168 ARG A N 1 ATOM 1287 C CA . ARG A 1 168 ? 59.495 7.020 -3.425 1.00 34.04 ? 168 ARG A CA 1 ATOM 1288 C C . ARG A 1 168 ? 58.581 8.104 -2.844 1.00 37.66 ? 168 ARG A C 1 ATOM 1289 O O . ARG A 1 168 ? 57.453 7.789 -2.473 1.00 37.83 ? 168 ARG A O 1 ATOM 1290 C CB . ARG A 1 168 ? 60.361 6.366 -2.341 1.00 33.08 ? 168 ARG A CB 1 ATOM 1291 C CG . ARG A 1 168 ? 61.256 5.234 -2.839 1.00 37.98 ? 168 ARG A CG 1 ATOM 1292 C CD . ARG A 1 168 ? 61.613 4.229 -1.751 1.00 39.96 ? 168 ARG A CD 1 ATOM 1293 N NE . ARG A 1 168 ? 62.377 4.805 -0.646 1.00 41.58 ? 168 ARG A NE 1 ATOM 1294 C CZ . ARG A 1 168 ? 63.705 4.853 -0.585 1.00 61.30 ? 168 ARG A CZ 1 ATOM 1295 N NH1 . ARG A 1 168 ? 64.442 4.380 -1.585 1.00 49.70 ? 168 ARG A NH1 1 ATOM 1296 N NH2 . ARG A 1 168 ? 64.308 5.402 0.461 1.00 49.41 ? 168 ARG A NH2 1 ATOM 1297 N N . VAL A 1 169 ? 59.049 9.370 -2.794 1.00 33.51 ? 169 VAL A N 1 ATOM 1298 C CA . VAL A 1 169 ? 58.264 10.514 -2.312 1.00 33.74 ? 169 VAL A CA 1 ATOM 1299 C C . VAL A 1 169 ? 57.185 10.821 -3.395 1.00 39.87 ? 169 VAL A C 1 ATOM 1300 O O . VAL A 1 169 ? 56.056 11.235 -3.067 1.00 39.76 ? 169 VAL A O 1 ATOM 1301 C CB . VAL A 1 169 ? 59.159 11.746 -1.942 1.00 36.99 ? 169 VAL A CB 1 ATOM 1302 C CG1 . VAL A 1 169 ? 58.337 12.931 -1.457 1.00 36.38 ? 169 VAL A CG1 1 ATOM 1303 C CG2 . VAL A 1 169 ? 60.206 11.384 -0.893 1.00 36.59 ? 169 VAL A CG2 1 ATOM 1304 N N . CYS A 1 170 ? 57.524 10.545 -4.679 1.00 35.82 ? 170 CYS A N 1 ATOM 1305 C CA . CYS A 1 170 ? 56.600 10.723 -5.802 1.00 35.16 ? 170 CYS A CA 1 ATOM 1306 C C . CYS A 1 170 ? 55.486 9.690 -5.788 1.00 38.46 ? 170 CYS A C 1 ATOM 1307 O O . CYS A 1 170 ? 54.346 10.034 -6.096 1.00 37.89 ? 170 CYS A O 1 ATOM 1308 C CB . CYS A 1 170 ? 57.339 10.748 -7.134 1.00 35.02 ? 170 CYS A CB 1 ATOM 1309 S SG . CYS A 1 170 ? 58.330 12.237 -7.386 1.00 38.66 ? 170 CYS A SG 1 ATOM 1310 N N . GLU A 1 171 ? 55.811 8.431 -5.407 1.00 34.38 ? 171 GLU A N 1 ATOM 1311 C CA . GLU A 1 171 ? 54.864 7.334 -5.265 1.00 33.66 ? 171 GLU A CA 1 ATOM 1312 C C . GLU A 1 171 ? 53.871 7.741 -4.184 1.00 39.98 ? 171 GLU A C 1 ATOM 1313 O O . GLU A 1 171 ? 52.671 7.525 -4.341 1.00 41.12 ? 171 GLU A O 1 ATOM 1314 C CB . GLU A 1 171 ? 55.571 6.062 -4.798 1.00 34.70 ? 171 GLU A CB 1 ATOM 1315 C CG . GLU A 1 171 ? 56.403 5.343 -5.835 1.00 41.20 ? 171 GLU A CG 1 ATOM 1316 C CD . GLU A 1 171 ? 56.846 3.987 -5.327 1.00 47.57 ? 171 GLU A CD 1 ATOM 1317 O OE1 . GLU A 1 171 ? 56.029 3.043 -5.376 1.00 26.88 ? 171 GLU A OE1 1 ATOM 1318 O OE2 . GLU A 1 171 ? 57.975 3.888 -4.796 1.00 43.23 ? 171 GLU A OE2 1 ATOM 1319 N N . LYS A 1 172 ? 54.381 8.338 -3.083 1.00 36.72 ? 172 LYS A N 1 ATOM 1320 C CA . LYS A 1 172 ? 53.570 8.841 -1.965 1.00 35.70 ? 172 LYS A CA 1 ATOM 1321 C C . LYS A 1 172 ? 52.571 9.921 -2.449 1.00 40.16 ? 172 LYS A C 1 ATOM 1322 O O . LYS A 1 172 ? 51.410 9.890 -2.034 1.00 41.39 ? 172 LYS A O 1 ATOM 1323 C CB . LYS A 1 172 ? 54.458 9.351 -0.826 1.00 35.96 ? 172 LYS A CB 1 ATOM 1324 C CG . LYS A 1 172 ? 55.229 8.269 -0.082 1.00 29.13 ? 172 LYS A CG 1 ATOM 1325 C CD . LYS A 1 172 ? 55.866 8.877 1.165 1.00 38.51 ? 172 LYS A CD 1 ATOM 1326 C CE . LYS A 1 172 ? 56.977 8.057 1.786 1.00 55.47 ? 172 LYS A CE 1 ATOM 1327 N NZ . LYS A 1 172 ? 58.231 7.979 0.971 1.00 62.61 ? 172 LYS A NZ 1 ATOM 1328 N N A MET A 1 173 ? 53.013 10.829 -3.346 0.50 36.53 ? 173 MET A N 1 ATOM 1329 N N B MET A 1 173 ? 53.018 10.838 -3.344 0.50 34.83 ? 173 MET A N 1 ATOM 1330 C CA A MET A 1 173 ? 52.178 11.881 -3.928 0.50 36.24 ? 173 MET A CA 1 ATOM 1331 C CA B MET A 1 173 ? 52.195 11.897 -3.941 0.50 33.66 ? 173 MET A CA 1 ATOM 1332 C C A MET A 1 173 ? 51.046 11.303 -4.778 0.50 40.01 ? 173 MET A C 1 ATOM 1333 C C B MET A 1 173 ? 51.052 11.305 -4.773 0.50 38.90 ? 173 MET A C 1 ATOM 1334 O O A MET A 1 173 ? 49.891 11.678 -4.588 0.50 40.28 ? 173 MET A O 1 ATOM 1335 O O B MET A 1 173 ? 49.898 11.674 -4.571 0.50 39.22 ? 173 MET A O 1 ATOM 1336 C CB A MET A 1 173 ? 53.024 12.859 -4.754 0.50 38.56 ? 173 MET A CB 1 ATOM 1337 C CB B MET A 1 173 ? 53.045 12.833 -4.821 0.50 35.17 ? 173 MET A CB 1 ATOM 1338 C CG A MET A 1 173 ? 53.809 13.834 -3.911 0.50 42.31 ? 173 MET A CG 1 ATOM 1339 C CG B MET A 1 173 ? 53.897 13.817 -4.051 0.50 37.63 ? 173 MET A CG 1 ATOM 1340 S SD A MET A 1 173 ? 54.786 15.070 -4.804 0.50 46.62 ? 173 MET A SD 1 ATOM 1341 S SD B MET A 1 173 ? 55.481 14.144 -4.867 0.50 40.43 ? 173 MET A SD 1 ATOM 1342 C CE A MET A 1 173 ? 53.634 15.650 -6.037 0.50 43.53 ? 173 MET A CE 1 ATOM 1343 C CE B MET A 1 173 ? 55.015 15.405 -5.986 0.50 37.27 ? 173 MET A CE 1 ATOM 1344 N N . ALA A 1 174 ? 51.375 10.372 -5.679 1.00 36.34 ? 174 ALA A N 1 ATOM 1345 C CA . ALA A 1 174 ? 50.423 9.733 -6.588 1.00 36.84 ? 174 ALA A CA 1 ATOM 1346 C C . ALA A 1 174 ? 49.499 8.690 -5.968 1.00 42.54 ? 174 ALA A C 1 ATOM 1347 O O . ALA A 1 174 ? 48.323 8.608 -6.348 1.00 42.52 ? 174 ALA A O 1 ATOM 1348 C CB . ALA A 1 174 ? 51.177 9.109 -7.758 1.00 37.32 ? 174 ALA A CB 1 ATOM 1349 N N . LEU A 1 175 ? 50.036 7.862 -5.051 1.00 38.90 ? 175 LEU A N 1 ATOM 1350 C CA . LEU A 1 175 ? 49.320 6.698 -4.549 1.00 37.63 ? 175 LEU A CA 1 ATOM 1351 C C . LEU A 1 175 ? 49.135 6.554 -3.023 1.00 40.30 ? 175 LEU A C 1 ATOM 1352 O O . LEU A 1 175 ? 48.441 5.612 -2.623 1.00 39.91 ? 175 LEU A O 1 ATOM 1353 C CB . LEU A 1 175 ? 50.032 5.444 -5.109 1.00 36.80 ? 175 LEU A CB 1 ATOM 1354 C CG . LEU A 1 175 ? 49.790 5.213 -6.595 1.00 39.97 ? 175 LEU A CG 1 ATOM 1355 C CD1 . LEU A 1 175 ? 50.990 4.624 -7.257 1.00 39.65 ? 175 LEU A CD1 1 ATOM 1356 C CD2 . LEU A 1 175 ? 48.518 4.420 -6.841 1.00 40.76 ? 175 LEU A CD2 1 ATOM 1357 N N . TYR A 1 176 ? 49.678 7.458 -2.182 1.00 35.26 ? 176 TYR A N 1 ATOM 1358 C CA . TYR A 1 176 ? 49.479 7.267 -0.745 1.00 34.70 ? 176 TYR A CA 1 ATOM 1359 C C . TYR A 1 176 ? 47.993 7.182 -0.365 1.00 38.98 ? 176 TYR A C 1 ATOM 1360 O O . TYR A 1 176 ? 47.606 6.215 0.276 1.00 37.28 ? 176 TYR A O 1 ATOM 1361 C CB . TYR A 1 176 ? 50.234 8.285 0.133 1.00 35.11 ? 176 TYR A CB 1 ATOM 1362 C CG . TYR A 1 176 ? 50.069 8.001 1.612 1.00 35.98 ? 176 TYR A CG 1 ATOM 1363 C CD1 . TYR A 1 176 ? 50.896 7.088 2.265 1.00 38.45 ? 176 TYR A CD1 1 ATOM 1364 C CD2 . TYR A 1 176 ? 49.026 8.573 2.340 1.00 35.53 ? 176 TYR A CD2 1 ATOM 1365 C CE1 . TYR A 1 176 ? 50.717 6.785 3.618 1.00 39.07 ? 176 TYR A CE1 1 ATOM 1366 C CE2 . TYR A 1 176 ? 48.825 8.261 3.684 1.00 35.69 ? 176 TYR A CE2 1 ATOM 1367 C CZ . TYR A 1 176 ? 49.677 7.373 4.320 1.00 43.29 ? 176 TYR A CZ 1 ATOM 1368 O OH . TYR A 1 176 ? 49.495 7.094 5.649 1.00 45.99 ? 176 TYR A OH 1 ATOM 1369 N N . ASP A 1 177 ? 47.169 8.159 -0.771 1.00 38.29 ? 177 ASP A N 1 ATOM 1370 C CA . ASP A 1 177 ? 45.728 8.160 -0.468 1.00 39.21 ? 177 ASP A CA 1 ATOM 1371 C C . ASP A 1 177 ? 44.993 6.979 -1.124 1.00 44.29 ? 177 ASP A C 1 ATOM 1372 O O . ASP A 1 177 ? 43.980 6.538 -0.583 1.00 45.42 ? 177 ASP A O 1 ATOM 1373 C CB . ASP A 1 177 ? 45.069 9.500 -0.856 1.00 41.48 ? 177 ASP A CB 1 ATOM 1374 C CG . ASP A 1 177 ? 43.775 9.798 -0.126 1.00 54.95 ? 177 ASP A CG 1 ATOM 1375 O OD1 . ASP A 1 177 ? 43.750 9.669 1.118 1.00 56.55 ? 177 ASP A OD1 1 ATOM 1376 O OD2 . ASP A 1 177 ? 42.809 10.228 -0.786 1.00 62.24 ? 177 ASP A OD2 1 ATOM 1377 N N . VAL A 1 178 ? 45.516 6.459 -2.269 1.00 39.16 ? 178 VAL A N 1 ATOM 1378 C CA . VAL A 1 178 ? 44.960 5.306 -2.987 1.00 37.85 ? 178 VAL A CA 1 ATOM 1379 C C . VAL A 1 178 ? 45.128 4.023 -2.154 1.00 39.06 ? 178 VAL A C 1 ATOM 1380 O O . VAL A 1 178 ? 44.124 3.431 -1.759 1.00 39.36 ? 178 VAL A O 1 ATOM 1381 C CB . VAL A 1 178 ? 45.518 5.152 -4.436 1.00 40.98 ? 178 VAL A CB 1 ATOM 1382 C CG1 . VAL A 1 178 ? 45.084 3.830 -5.077 1.00 40.42 ? 178 VAL A CG1 1 ATOM 1383 C CG2 . VAL A 1 178 ? 45.099 6.322 -5.308 1.00 40.60 ? 178 VAL A CG2 1 ATOM 1384 N N . VAL A 1 179 ? 46.386 3.610 -1.878 1.00 32.62 ? 179 VAL A N 1 ATOM 1385 C CA . VAL A 1 179 ? 46.723 2.393 -1.113 1.00 31.36 ? 179 VAL A CA 1 ATOM 1386 C C . VAL A 1 179 ? 46.079 2.407 0.288 1.00 37.49 ? 179 VAL A C 1 ATOM 1387 O O . VAL A 1 179 ? 45.880 1.358 0.911 1.00 37.35 ? 179 VAL A O 1 ATOM 1388 C CB . VAL A 1 179 ? 48.255 2.095 -1.071 1.00 33.58 ? 179 VAL A CB 1 ATOM 1389 C CG1 . VAL A 1 179 ? 48.861 2.056 -2.485 1.00 32.81 ? 179 VAL A CG1 1 ATOM 1390 C CG2 . VAL A 1 179 ? 49.011 3.073 -0.167 1.00 33.03 ? 179 VAL A CG2 1 ATOM 1391 N N . SER A 1 180 ? 45.713 3.604 0.748 1.00 35.80 ? 180 SER A N 1 ATOM 1392 C CA . SER A 1 180 ? 45.084 3.824 2.038 1.00 36.36 ? 180 SER A CA 1 ATOM 1393 C C . SER A 1 180 ? 43.571 3.613 2.020 1.00 43.65 ? 180 SER A C 1 ATOM 1394 O O . SER A 1 180 ? 43.052 3.025 2.973 1.00 44.72 ? 180 SER A O 1 ATOM 1395 C CB . SER A 1 180 ? 45.397 5.233 2.541 1.00 37.48 ? 180 SER A CB 1 ATOM 1396 O OG . SER A 1 180 ? 46.795 5.431 2.654 1.00 37.36 ? 180 SER A OG 1 ATOM 1397 N N A THR A 1 181 ? 42.876 4.085 0.957 0.50 40.25 ? 181 THR A N 1 ATOM 1398 N N B THR A 1 181 ? 42.873 4.087 0.960 0.50 39.75 ? 181 THR A N 1 ATOM 1399 C CA A THR A 1 181 ? 41.415 4.035 0.838 0.50 40.21 ? 181 THR A CA 1 ATOM 1400 C CA B THR A 1 181 ? 41.413 4.036 0.834 0.50 39.47 ? 181 THR A CA 1 ATOM 1401 C C A THR A 1 181 ? 40.854 2.905 -0.038 0.50 42.87 ? 181 THR A C 1 ATOM 1402 C C B THR A 1 181 ? 40.873 2.876 -0.020 0.50 42.60 ? 181 THR A C 1 ATOM 1403 O O A THR A 1 181 ? 39.812 2.355 0.309 0.50 42.69 ? 181 THR A O 1 ATOM 1404 O O B THR A 1 181 ? 39.866 2.281 0.358 0.50 42.54 ? 181 THR A O 1 ATOM 1405 C CB A THR A 1 181 ? 40.870 5.393 0.361 0.50 53.54 ? 181 THR A CB 1 ATOM 1406 C CB B THR A 1 181 ? 40.885 5.391 0.311 0.50 49.16 ? 181 THR A CB 1 ATOM 1407 O OG1 A THR A 1 181 ? 41.430 5.718 -0.914 0.50 54.19 ? 181 THR A OG1 1 ATOM 1408 O OG1 B THR A 1 181 ? 41.673 6.458 0.850 0.50 48.41 ? 181 THR A OG1 1 ATOM 1409 C CG2 A THR A 1 181 ? 41.139 6.519 1.356 0.50 53.36 ? 181 THR A CG2 1 ATOM 1410 C CG2 B THR A 1 181 ? 39.398 5.616 0.622 0.50 46.63 ? 181 THR A CG2 1 ATOM 1411 N N . LEU A 1 182 ? 41.498 2.594 -1.176 1.00 38.53 ? 182 LEU A N 1 ATOM 1412 C CA . LEU A 1 182 ? 41.044 1.564 -2.134 1.00 37.35 ? 182 LEU A CA 1 ATOM 1413 C C . LEU A 1 182 ? 40.885 0.114 -1.597 1.00 40.61 ? 182 LEU A C 1 ATOM 1414 O O . LEU A 1 182 ? 39.854 -0.482 -1.919 1.00 40.82 ? 182 LEU A O 1 ATOM 1415 C CB . LEU A 1 182 ? 41.942 1.548 -3.380 1.00 36.93 ? 182 LEU A CB 1 ATOM 1416 C CG . LEU A 1 182 ? 41.505 0.674 -4.547 1.00 40.47 ? 182 LEU A CG 1 ATOM 1417 C CD1 . LEU A 1 182 ? 40.623 1.429 -5.460 1.00 40.50 ? 182 LEU A CD1 1 ATOM 1418 C CD2 . LEU A 1 182 ? 42.686 0.242 -5.342 1.00 42.33 ? 182 LEU A CD2 1 ATOM 1419 N N . PRO A 1 183 ? 41.850 -0.514 -0.865 1.00 35.28 ? 183 PRO A N 1 ATOM 1420 C CA . PRO A 1 183 ? 41.653 -1.915 -0.458 1.00 34.50 ? 183 PRO A CA 1 ATOM 1421 C C . PRO A 1 183 ? 40.397 -2.183 0.371 1.00 38.47 ? 183 PRO A C 1 ATOM 1422 O O . PRO A 1 183 ? 39.764 -3.224 0.190 1.00 36.74 ? 183 PRO A O 1 ATOM 1423 C CB . PRO A 1 183 ? 42.938 -2.246 0.305 1.00 35.80 ? 183 PRO A CB 1 ATOM 1424 C CG . PRO A 1 183 ? 43.930 -1.289 -0.164 1.00 39.95 ? 183 PRO A CG 1 ATOM 1425 C CD . PRO A 1 183 ? 43.161 -0.024 -0.391 1.00 36.32 ? 183 PRO A CD 1 ATOM 1426 N N . GLN A 1 184 ? 40.022 -1.228 1.247 1.00 35.94 ? 184 GLN A N 1 ATOM 1427 C CA . GLN A 1 184 ? 38.840 -1.322 2.097 1.00 35.46 ? 184 GLN A CA 1 ATOM 1428 C C . GLN A 1 184 ? 37.550 -1.242 1.290 1.00 37.26 ? 184 GLN A C 1 ATOM 1429 O O . GLN A 1 184 ? 36.608 -1.971 1.605 1.00 38.17 ? 184 GLN A O 1 ATOM 1430 C CB . GLN A 1 184 ? 38.854 -0.240 3.180 1.00 37.30 ? 184 GLN A CB 1 ATOM 1431 C CG . GLN A 1 184 ? 38.287 -0.703 4.524 1.00 69.94 ? 184 GLN A CG 1 ATOM 1432 C CD . GLN A 1 184 ? 36.778 -0.830 4.544 1.00 100.31 ? 184 GLN A CD 1 ATOM 1433 O OE1 . GLN A 1 184 ? 36.037 0.145 4.341 1.00 98.80 ? 184 GLN A OE1 1 ATOM 1434 N NE2 . GLN A 1 184 ? 36.289 -2.042 4.781 1.00 92.25 ? 184 GLN A NE2 1 ATOM 1435 N N . VAL A 1 185 ? 37.490 -0.367 0.267 1.00 31.00 ? 185 VAL A N 1 ATOM 1436 C CA . VAL A 1 185 ? 36.286 -0.215 -0.565 1.00 30.37 ? 185 VAL A CA 1 ATOM 1437 C C . VAL A 1 185 ? 36.042 -1.481 -1.423 1.00 37.30 ? 185 VAL A C 1 ATOM 1438 O O . VAL A 1 185 ? 34.963 -2.080 -1.371 1.00 38.42 ? 185 VAL A O 1 ATOM 1439 C CB . VAL A 1 185 ? 36.320 1.074 -1.433 1.00 32.43 ? 185 VAL A CB 1 ATOM 1440 C CG1 . VAL A 1 185 ? 35.072 1.209 -2.307 1.00 31.64 ? 185 VAL A CG1 1 ATOM 1441 C CG2 . VAL A 1 185 ? 36.512 2.318 -0.574 1.00 31.73 ? 185 VAL A CG2 1 ATOM 1442 N N . VAL A 1 186 ? 37.054 -1.880 -2.185 1.00 33.85 ? 186 VAL A N 1 ATOM 1443 C CA . VAL A 1 186 ? 37.022 -3.027 -3.086 1.00 33.98 ? 186 VAL A CA 1 ATOM 1444 C C . VAL A 1 186 ? 36.724 -4.380 -2.394 1.00 39.78 ? 186 VAL A C 1 ATOM 1445 O O . VAL A 1 186 ? 35.971 -5.197 -2.935 1.00 40.41 ? 186 VAL A O 1 ATOM 1446 C CB . VAL A 1 186 ? 38.351 -3.077 -3.876 1.00 36.94 ? 186 VAL A CB 1 ATOM 1447 C CG1 . VAL A 1 186 ? 38.539 -4.422 -4.560 1.00 36.65 ? 186 VAL A CG1 1 ATOM 1448 C CG2 . VAL A 1 186 ? 38.446 -1.927 -4.875 1.00 36.60 ? 186 VAL A CG2 1 ATOM 1449 N N . MET A 1 187 ? 37.328 -4.603 -1.219 1.00 35.77 ? 187 MET A N 1 ATOM 1450 C CA . MET A 1 187 ? 37.287 -5.867 -0.494 1.00 35.27 ? 187 MET A CA 1 ATOM 1451 C C . MET A 1 187 ? 36.451 -5.889 0.769 1.00 39.09 ? 187 MET A C 1 ATOM 1452 O O . MET A 1 187 ? 36.134 -6.981 1.248 1.00 38.16 ? 187 MET A O 1 ATOM 1453 C CB . MET A 1 187 ? 38.713 -6.305 -0.184 1.00 37.65 ? 187 MET A CB 1 ATOM 1454 C CG . MET A 1 187 ? 39.535 -6.487 -1.448 1.00 41.87 ? 187 MET A CG 1 ATOM 1455 S SD . MET A 1 187 ? 41.287 -6.425 -1.134 1.00 46.55 ? 187 MET A SD 1 ATOM 1456 C CE . MET A 1 187 ? 41.391 -7.732 0.114 1.00 43.90 ? 187 MET A CE 1 ATOM 1457 N N . GLY A 1 188 ? 36.081 -4.715 1.278 1.00 36.13 ? 188 GLY A N 1 ATOM 1458 C CA . GLY A 1 188 ? 35.268 -4.593 2.479 1.00 36.45 ? 188 GLY A CA 1 ATOM 1459 C C . GLY A 1 188 ? 35.873 -5.275 3.688 1.00 42.96 ? 188 GLY A C 1 ATOM 1460 O O . GLY A 1 188 ? 37.054 -5.090 3.985 1.00 42.81 ? 188 GLY A O 1 ATOM 1461 N N . SER A 1 189 ? 35.073 -6.106 4.372 1.00 40.92 ? 189 SER A N 1 ATOM 1462 C CA . SER A 1 189 ? 35.506 -6.819 5.565 1.00 40.86 ? 189 SER A CA 1 ATOM 1463 C C . SER A 1 189 ? 36.590 -7.893 5.284 1.00 46.21 ? 189 SER A C 1 ATOM 1464 O O . SER A 1 189 ? 37.224 -8.374 6.232 1.00 46.01 ? 189 SER A O 1 ATOM 1465 C CB . SER A 1 189 ? 34.312 -7.386 6.327 1.00 43.70 ? 189 SER A CB 1 ATOM 1466 O OG . SER A 1 189 ? 33.591 -8.353 5.583 1.00 54.95 ? 189 SER A OG 1 ATOM 1467 N N . SER A 1 190 ? 36.836 -8.241 3.994 1.00 43.30 ? 190 SER A N 1 ATOM 1468 C CA . SER A 1 190 ? 37.894 -9.194 3.608 1.00 43.17 ? 190 SER A CA 1 ATOM 1469 C C . SER A 1 190 ? 39.272 -8.553 3.775 1.00 48.33 ? 190 SER A C 1 ATOM 1470 O O . SER A 1 190 ? 40.250 -9.267 4.013 1.00 48.55 ? 190 SER A O 1 ATOM 1471 C CB . SER A 1 190 ? 37.703 -9.712 2.187 1.00 45.33 ? 190 SER A CB 1 ATOM 1472 O OG . SER A 1 190 ? 36.598 -10.598 2.123 1.00 51.36 ? 190 SER A OG 1 ATOM 1473 N N . TYR A 1 191 ? 39.343 -7.201 3.710 1.00 44.71 ? 191 TYR A N 1 ATOM 1474 C CA . TYR A 1 191 ? 40.598 -6.482 3.899 1.00 44.06 ? 191 TYR A CA 1 ATOM 1475 C C . TYR A 1 191 ? 41.003 -6.528 5.358 1.00 48.87 ? 191 TYR A C 1 ATOM 1476 O O . TYR A 1 191 ? 40.317 -5.949 6.206 1.00 50.72 ? 191 TYR A O 1 ATOM 1477 C CB . TYR A 1 191 ? 40.524 -5.038 3.391 1.00 44.68 ? 191 TYR A CB 1 ATOM 1478 C CG . TYR A 1 191 ? 41.884 -4.383 3.376 1.00 45.80 ? 191 TYR A CG 1 ATOM 1479 C CD1 . TYR A 1 191 ? 42.962 -4.982 2.724 1.00 47.53 ? 191 TYR A CD1 1 ATOM 1480 C CD2 . TYR A 1 191 ? 42.105 -3.179 4.036 1.00 46.23 ? 191 TYR A CD2 1 ATOM 1481 C CE1 . TYR A 1 191 ? 44.226 -4.401 2.735 1.00 47.65 ? 191 TYR A CE1 1 ATOM 1482 C CE2 . TYR A 1 191 ? 43.360 -2.573 4.027 1.00 47.03 ? 191 TYR A CE2 1 ATOM 1483 C CZ . TYR A 1 191 ? 44.411 -3.182 3.362 1.00 53.61 ? 191 TYR A CZ 1 ATOM 1484 O OH . TYR A 1 191 ? 45.647 -2.603 3.360 1.00 54.70 ? 191 TYR A OH 1 ATOM 1485 N N . GLY A 1 192 ? 42.073 -7.264 5.639 1.00 43.15 ? 192 GLY A N 1 ATOM 1486 C CA . GLY A 1 192 ? 42.585 -7.460 6.990 1.00 41.79 ? 192 GLY A CA 1 ATOM 1487 C C . GLY A 1 192 ? 43.417 -6.349 7.598 1.00 43.06 ? 192 GLY A C 1 ATOM 1488 O O . GLY A 1 192 ? 43.381 -6.157 8.815 1.00 42.91 ? 192 GLY A O 1 ATOM 1489 N N . PHE A 1 193 ? 44.190 -5.621 6.780 1.00 37.63 ? 193 PHE A N 1 ATOM 1490 C CA . PHE A 1 193 ? 45.081 -4.572 7.277 1.00 36.60 ? 193 PHE A CA 1 ATOM 1491 C C . PHE A 1 193 ? 44.357 -3.370 7.920 1.00 41.42 ? 193 PHE A C 1 ATOM 1492 O O . PHE A 1 193 ? 45.021 -2.469 8.428 1.00 42.58 ? 193 PHE A O 1 ATOM 1493 C CB . PHE A 1 193 ? 46.052 -4.113 6.182 1.00 37.87 ? 193 PHE A CB 1 ATOM 1494 C CG . PHE A 1 193 ? 47.175 -5.059 5.799 1.00 39.48 ? 193 PHE A CG 1 ATOM 1495 C CD1 . PHE A 1 193 ? 47.956 -5.678 6.776 1.00 43.09 ? 193 PHE A CD1 1 ATOM 1496 C CD2 . PHE A 1 193 ? 47.511 -5.260 4.466 1.00 41.73 ? 193 PHE A CD2 1 ATOM 1497 C CE1 . PHE A 1 193 ? 49.018 -6.522 6.417 1.00 43.52 ? 193 PHE A CE1 1 ATOM 1498 C CE2 . PHE A 1 193 ? 48.567 -6.115 4.108 1.00 44.23 ? 193 PHE A CE2 1 ATOM 1499 C CZ . PHE A 1 193 ? 49.316 -6.728 5.085 1.00 42.14 ? 193 PHE A CZ 1 ATOM 1500 N N . GLN A 1 194 ? 43.016 -3.375 7.945 1.00 36.76 ? 194 GLN A N 1 ATOM 1501 C CA . GLN A 1 194 ? 42.195 -2.327 8.540 1.00 36.05 ? 194 GLN A CA 1 ATOM 1502 C C . GLN A 1 194 ? 41.882 -2.664 10.013 1.00 44.03 ? 194 GLN A C 1 ATOM 1503 O O . GLN A 1 194 ? 41.389 -1.808 10.756 1.00 45.74 ? 194 GLN A O 1 ATOM 1504 C CB . GLN A 1 194 ? 40.887 -2.202 7.748 1.00 36.80 ? 194 GLN A CB 1 ATOM 1505 C CG . GLN A 1 194 ? 39.837 -3.271 8.100 1.00 39.98 ? 194 GLN A CG 1 ATOM 1506 C CD . GLN A 1 194 ? 38.518 -3.091 7.395 1.00 60.48 ? 194 GLN A CD 1 ATOM 1507 O OE1 . GLN A 1 194 ? 37.810 -2.077 7.548 1.00 53.57 ? 194 GLN A OE1 1 ATOM 1508 N NE2 . GLN A 1 194 ? 38.126 -4.121 6.660 1.00 54.88 ? 194 GLN A NE2 1 ATOM 1509 N N . TYR A 1 195 ? 42.098 -3.930 10.411 1.00 40.35 ? 195 TYR A N 1 ATOM 1510 C CA . TYR A 1 195 ? 41.786 -4.405 11.753 1.00 39.32 ? 195 TYR A CA 1 ATOM 1511 C C . TYR A 1 195 ? 42.958 -4.376 12.671 1.00 43.44 ? 195 TYR A C 1 ATOM 1512 O O . TYR A 1 195 ? 44.087 -4.636 12.254 1.00 44.43 ? 195 TYR A O 1 ATOM 1513 C CB . TYR A 1 195 ? 41.296 -5.870 11.725 1.00 39.71 ? 195 TYR A CB 1 ATOM 1514 C CG . TYR A 1 195 ? 40.118 -6.144 10.822 1.00 39.60 ? 195 TYR A CG 1 ATOM 1515 C CD1 . TYR A 1 195 ? 38.883 -5.545 11.055 1.00 41.11 ? 195 TYR A CD1 1 ATOM 1516 C CD2 . TYR A 1 195 ? 40.217 -7.055 9.774 1.00 38.98 ? 195 TYR A CD2 1 ATOM 1517 C CE1 . TYR A 1 195 ? 37.796 -5.792 10.225 1.00 40.50 ? 195 TYR A CE1 1 ATOM 1518 C CE2 . TYR A 1 195 ? 39.129 -7.328 8.952 1.00 39.08 ? 195 TYR A CE2 1 ATOM 1519 C CZ . TYR A 1 195 ? 37.922 -6.691 9.179 1.00 42.21 ? 195 TYR A CZ 1 ATOM 1520 O OH . TYR A 1 195 ? 36.845 -6.940 8.379 1.00 36.98 ? 195 TYR A OH 1 ATOM 1521 N N . SER A 1 196 ? 42.658 -4.198 13.960 1.00 38.43 ? 196 SER A N 1 ATOM 1522 C CA . SER A 1 196 ? 43.588 -4.331 15.062 1.00 37.27 ? 196 SER A CA 1 ATOM 1523 C C . SER A 1 196 ? 43.606 -5.857 15.303 1.00 40.05 ? 196 SER A C 1 ATOM 1524 O O . SER A 1 196 ? 42.698 -6.525 14.803 1.00 36.55 ? 196 SER A O 1 ATOM 1525 C CB . SER A 1 196 ? 43.023 -3.629 16.291 1.00 40.28 ? 196 SER A CB 1 ATOM 1526 O OG . SER A 1 196 ? 41.949 -4.378 16.837 1.00 47.83 ? 196 SER A OG 1 ATOM 1527 N N . PRO A 1 197 ? 44.560 -6.456 16.063 1.00 39.34 ? 197 PRO A N 1 ATOM 1528 C CA . PRO A 1 197 ? 44.488 -7.914 16.282 1.00 39.11 ? 197 PRO A CA 1 ATOM 1529 C C . PRO A 1 197 ? 43.196 -8.316 16.994 1.00 41.84 ? 197 PRO A C 1 ATOM 1530 O O . PRO A 1 197 ? 42.628 -9.366 16.685 1.00 40.76 ? 197 PRO A O 1 ATOM 1531 C CB . PRO A 1 197 ? 45.750 -8.220 17.100 1.00 41.14 ? 197 PRO A CB 1 ATOM 1532 C CG . PRO A 1 197 ? 46.671 -7.060 16.835 1.00 46.20 ? 197 PRO A CG 1 ATOM 1533 C CD . PRO A 1 197 ? 45.744 -5.879 16.734 1.00 41.65 ? 197 PRO A CD 1 ATOM 1534 N N . GLY A 1 198 ? 42.703 -7.429 17.865 1.00 38.31 ? 198 GLY A N 1 ATOM 1535 C CA . GLY A 1 198 ? 41.463 -7.627 18.606 1.00 37.81 ? 198 GLY A CA 1 ATOM 1536 C C . GLY A 1 198 ? 40.238 -7.700 17.716 1.00 41.34 ? 198 GLY A C 1 ATOM 1537 O O . GLY A 1 198 ? 39.356 -8.532 17.948 1.00 42.21 ? 198 GLY A O 1 ATOM 1538 N N . GLN A 1 199 ? 40.180 -6.832 16.686 1.00 36.08 ? 199 GLN A N 1 ATOM 1539 C CA . GLN A 1 199 ? 39.092 -6.775 15.707 1.00 35.59 ? 199 GLN A CA 1 ATOM 1540 C C . GLN A 1 199 ? 39.254 -7.888 14.660 1.00 40.06 ? 199 GLN A C 1 ATOM 1541 O O . GLN A 1 199 ? 38.280 -8.272 14.005 1.00 39.72 ? 199 GLN A O 1 ATOM 1542 C CB . GLN A 1 199 ? 39.078 -5.411 15.006 1.00 36.94 ? 199 GLN A CB 1 ATOM 1543 C CG . GLN A 1 199 ? 38.694 -4.239 15.910 1.00 39.46 ? 199 GLN A CG 1 ATOM 1544 C CD . GLN A 1 199 ? 38.949 -2.877 15.311 1.00 49.09 ? 199 GLN A CD 1 ATOM 1545 O OE1 . GLN A 1 199 ? 39.851 -2.675 14.484 1.00 41.56 ? 199 GLN A OE1 1 ATOM 1546 N NE2 . GLN A 1 199 ? 38.223 -1.885 15.807 1.00 46.33 ? 199 GLN A NE2 1 ATOM 1547 N N . ARG A 1 200 ? 40.494 -8.395 14.496 1.00 36.44 ? 200 ARG A N 1 ATOM 1548 C CA . ARG A 1 200 ? 40.811 -9.470 13.568 1.00 35.68 ? 200 ARG A CA 1 ATOM 1549 C C . ARG A 1 200 ? 40.196 -10.742 14.111 1.00 39.33 ? 200 ARG A C 1 ATOM 1550 O O . ARG A 1 200 ? 39.602 -11.496 13.338 1.00 38.51 ? 200 ARG A O 1 ATOM 1551 C CB . ARG A 1 200 ? 42.327 -9.628 13.402 1.00 35.92 ? 200 ARG A CB 1 ATOM 1552 C CG . ARG A 1 200 ? 42.700 -10.395 12.155 1.00 48.30 ? 200 ARG A CG 1 ATOM 1553 C CD . ARG A 1 200 ? 44.102 -10.971 12.212 1.00 62.13 ? 200 ARG A CD 1 ATOM 1554 N NE . ARG A 1 200 ? 44.235 -12.143 11.343 1.00 66.80 ? 200 ARG A NE 1 ATOM 1555 C CZ . ARG A 1 200 ? 44.467 -12.081 10.038 1.00 81.74 ? 200 ARG A CZ 1 ATOM 1556 N NH1 . ARG A 1 200 ? 44.612 -10.906 9.437 1.00 73.09 ? 200 ARG A NH1 1 ATOM 1557 N NH2 . ARG A 1 200 ? 44.539 -13.190 9.319 1.00 69.00 ? 200 ARG A NH2 1 ATOM 1558 N N . VAL A 1 201 ? 40.301 -10.944 15.459 1.00 35.84 ? 201 VAL A N 1 ATOM 1559 C CA . VAL A 1 201 ? 39.730 -12.074 16.212 1.00 34.84 ? 201 VAL A CA 1 ATOM 1560 C C . VAL A 1 201 ? 38.225 -12.034 16.117 1.00 36.09 ? 201 VAL A C 1 ATOM 1561 O O . VAL A 1 201 ? 37.638 -13.022 15.672 1.00 35.18 ? 201 VAL A O 1 ATOM 1562 C CB . VAL A 1 201 ? 40.196 -12.107 17.692 1.00 39.00 ? 201 VAL A CB 1 ATOM 1563 C CG1 . VAL A 1 201 ? 39.236 -12.911 18.572 1.00 38.64 ? 201 VAL A CG1 1 ATOM 1564 C CG2 . VAL A 1 201 ? 41.601 -12.666 17.801 1.00 39.04 ? 201 VAL A CG2 1 ATOM 1565 N N . GLU A 1 202 ? 37.604 -10.889 16.519 1.00 32.28 ? 202 GLU A N 1 ATOM 1566 C CA . GLU A 1 202 ? 36.155 -10.702 16.490 1.00 33.33 ? 202 GLU A CA 1 ATOM 1567 C C . GLU A 1 202 ? 35.578 -11.115 15.144 1.00 41.21 ? 202 GLU A C 1 ATOM 1568 O O . GLU A 1 202 ? 34.660 -11.940 15.106 1.00 42.50 ? 202 GLU A O 1 ATOM 1569 C CB . GLU A 1 202 ? 35.767 -9.269 16.839 1.00 34.85 ? 202 GLU A CB 1 ATOM 1570 C CG . GLU A 1 202 ? 34.987 -9.182 18.137 1.00 48.10 ? 202 GLU A CG 1 ATOM 1571 C CD . GLU A 1 202 ? 33.631 -8.528 17.990 1.00 77.86 ? 202 GLU A CD 1 ATOM 1572 O OE1 . GLU A 1 202 ? 33.586 -7.342 17.589 1.00 83.27 ? 202 GLU A OE1 1 ATOM 1573 O OE2 . GLU A 1 202 ? 32.612 -9.201 18.273 1.00 69.69 ? 202 GLU A OE2 1 ATOM 1574 N N . PHE A 1 203 ? 36.197 -10.630 14.039 1.00 37.67 ? 203 PHE A N 1 ATOM 1575 C CA . PHE A 1 203 ? 35.820 -10.960 12.667 1.00 36.38 ? 203 PHE A CA 1 ATOM 1576 C C . PHE A 1 203 ? 35.832 -12.472 12.418 1.00 38.30 ? 203 PHE A C 1 ATOM 1577 O O . PHE A 1 203 ? 34.806 -13.009 12.046 1.00 37.82 ? 203 PHE A O 1 ATOM 1578 C CB . PHE A 1 203 ? 36.723 -10.211 11.670 1.00 37.91 ? 203 PHE A CB 1 ATOM 1579 C CG . PHE A 1 203 ? 36.476 -10.577 10.228 1.00 38.90 ? 203 PHE A CG 1 ATOM 1580 C CD1 . PHE A 1 203 ? 35.376 -10.070 9.544 1.00 41.67 ? 203 PHE A CD1 1 ATOM 1581 C CD2 . PHE A 1 203 ? 37.330 -11.447 9.560 1.00 39.60 ? 203 PHE A CD2 1 ATOM 1582 C CE1 . PHE A 1 203 ? 35.139 -10.426 8.217 1.00 42.10 ? 203 PHE A CE1 1 ATOM 1583 C CE2 . PHE A 1 203 ? 37.083 -11.814 8.240 1.00 41.81 ? 203 PHE A CE2 1 ATOM 1584 C CZ . PHE A 1 203 ? 36.005 -11.281 7.570 1.00 40.30 ? 203 PHE A CZ 1 ATOM 1585 N N . LEU A 1 204 ? 36.964 -13.147 12.680 1.00 34.87 ? 204 LEU A N 1 ATOM 1586 C CA . LEU A 1 204 ? 37.183 -14.586 12.490 1.00 34.98 ? 204 LEU A CA 1 ATOM 1587 C C . LEU A 1 204 ? 36.198 -15.465 13.248 1.00 40.87 ? 204 LEU A C 1 ATOM 1588 O O . LEU A 1 204 ? 35.647 -16.422 12.678 1.00 37.96 ? 204 LEU A O 1 ATOM 1589 C CB . LEU A 1 204 ? 38.609 -14.961 12.910 1.00 34.69 ? 204 LEU A CB 1 ATOM 1590 C CG . LEU A 1 204 ? 39.744 -14.511 12.001 1.00 38.70 ? 204 LEU A CG 1 ATOM 1591 C CD1 . LEU A 1 204 ? 41.059 -14.559 12.750 1.00 38.53 ? 204 LEU A CD1 1 ATOM 1592 C CD2 . LEU A 1 204 ? 39.789 -15.323 10.709 1.00 39.87 ? 204 LEU A CD2 1 ATOM 1593 N N . VAL A 1 205 ? 36.000 -15.144 14.549 1.00 41.17 ? 205 VAL A N 1 ATOM 1594 C CA . VAL A 1 205 ? 35.082 -15.839 15.463 1.00 41.80 ? 205 VAL A CA 1 ATOM 1595 C C . VAL A 1 205 ? 33.631 -15.697 14.955 1.00 45.31 ? 205 VAL A C 1 ATOM 1596 O O . VAL A 1 205 ? 32.949 -16.708 14.781 1.00 46.37 ? 205 VAL A O 1 ATOM 1597 C CB . VAL A 1 205 ? 35.266 -15.371 16.929 1.00 46.14 ? 205 VAL A CB 1 ATOM 1598 C CG1 . VAL A 1 205 ? 34.183 -15.947 17.844 1.00 46.24 ? 205 VAL A CG1 1 ATOM 1599 C CG2 . VAL A 1 205 ? 36.650 -15.738 17.442 1.00 46.04 ? 205 VAL A CG2 1 ATOM 1600 N N . ASN A 1 206 ? 33.196 -14.469 14.638 1.00 39.14 ? 206 ASN A N 1 ATOM 1601 C CA . ASN A 1 206 ? 31.869 -14.226 14.105 1.00 38.28 ? 206 ASN A CA 1 ATOM 1602 C C . ASN A 1 206 ? 31.645 -14.934 12.779 1.00 43.72 ? 206 ASN A C 1 ATOM 1603 O O . ASN A 1 206 ? 30.534 -15.396 12.539 1.00 43.57 ? 206 ASN A O 1 ATOM 1604 C CB . ASN A 1 206 ? 31.603 -12.734 14.002 1.00 37.83 ? 206 ASN A CB 1 ATOM 1605 C CG . ASN A 1 206 ? 31.462 -12.075 15.343 1.00 48.55 ? 206 ASN A CG 1 ATOM 1606 O OD1 . ASN A 1 206 ? 30.849 -12.613 16.269 1.00 48.90 ? 206 ASN A OD1 1 ATOM 1607 N ND2 . ASN A 1 206 ? 32.042 -10.902 15.483 1.00 32.99 ? 206 ASN A ND2 1 ATOM 1608 N N . THR A 1 207 ? 32.709 -15.052 11.944 1.00 42.02 ? 207 THR A N 1 ATOM 1609 C CA . THR A 1 207 ? 32.714 -15.752 10.648 1.00 42.32 ? 207 THR A CA 1 ATOM 1610 C C . THR A 1 207 ? 32.539 -17.270 10.867 1.00 47.66 ? 207 THR A C 1 ATOM 1611 O O . THR A 1 207 ? 31.713 -17.892 10.209 1.00 46.81 ? 207 THR A O 1 ATOM 1612 C CB . THR A 1 207 ? 34.027 -15.470 9.863 1.00 41.94 ? 207 THR A CB 1 ATOM 1613 O OG1 . THR A 1 207 ? 34.185 -14.076 9.657 1.00 37.85 ? 207 THR A OG1 1 ATOM 1614 C CG2 . THR A 1 207 ? 34.059 -16.145 8.526 1.00 35.66 ? 207 THR A CG2 1 ATOM 1615 N N . TRP A 1 208 ? 33.352 -17.856 11.759 1.00 45.64 ? 208 TRP A N 1 ATOM 1616 C CA . TRP A 1 208 ? 33.318 -19.285 12.075 1.00 45.67 ? 208 TRP A CA 1 ATOM 1617 C C . TRP A 1 208 ? 31.945 -19.669 12.638 1.00 48.16 ? 208 TRP A C 1 ATOM 1618 O O . TRP A 1 208 ? 31.377 -20.677 12.215 1.00 47.55 ? 208 TRP A O 1 ATOM 1619 C CB . TRP A 1 208 ? 34.439 -19.618 13.066 1.00 44.72 ? 208 TRP A CB 1 ATOM 1620 C CG . TRP A 1 208 ? 34.768 -21.071 13.149 1.00 46.00 ? 208 TRP A CG 1 ATOM 1621 C CD1 . TRP A 1 208 ? 34.293 -21.971 14.057 1.00 48.87 ? 208 TRP A CD1 1 ATOM 1622 C CD2 . TRP A 1 208 ? 35.660 -21.794 12.294 1.00 46.11 ? 208 TRP A CD2 1 ATOM 1623 N NE1 . TRP A 1 208 ? 34.845 -23.207 13.832 1.00 48.24 ? 208 TRP A NE1 1 ATOM 1624 C CE2 . TRP A 1 208 ? 35.686 -23.130 12.752 1.00 50.00 ? 208 TRP A CE2 1 ATOM 1625 C CE3 . TRP A 1 208 ? 36.438 -21.445 11.174 1.00 47.40 ? 208 TRP A CE3 1 ATOM 1626 C CZ2 . TRP A 1 208 ? 36.443 -24.121 12.119 1.00 49.45 ? 208 TRP A CZ2 1 ATOM 1627 C CZ3 . TRP A 1 208 ? 37.197 -22.425 10.558 1.00 48.89 ? 208 TRP A CZ3 1 ATOM 1628 C CH2 . TRP A 1 208 ? 37.207 -23.742 11.038 1.00 49.65 ? 208 TRP A CH2 1 ATOM 1629 N N . LYS A 1 209 ? 31.390 -18.814 13.531 1.00 43.74 ? 209 LYS A N 1 ATOM 1630 C CA . LYS A 1 209 ? 30.067 -18.975 14.153 1.00 42.78 ? 209 LYS A CA 1 ATOM 1631 C C . LYS A 1 209 ? 28.923 -18.807 13.129 1.00 47.57 ? 209 LYS A C 1 ATOM 1632 O O . LYS A 1 209 ? 27.837 -19.357 13.341 1.00 47.98 ? 209 LYS A O 1 ATOM 1633 C CB . LYS A 1 209 ? 29.887 -17.986 15.324 1.00 43.59 ? 209 LYS A CB 1 ATOM 1634 C CG . LYS A 1 209 ? 30.640 -18.368 16.591 1.00 48.79 ? 209 LYS A CG 1 ATOM 1635 C CD . LYS A 1 209 ? 30.571 -17.284 17.656 1.00 58.16 ? 209 LYS A CD 1 ATOM 1636 C CE . LYS A 1 209 ? 31.039 -17.793 19.003 1.00 76.60 ? 209 LYS A CE 1 ATOM 1637 N NZ . LYS A 1 209 ? 30.808 -16.799 20.093 1.00 89.37 ? 209 LYS A NZ 1 ATOM 1638 N N . SER A 1 210 ? 29.170 -18.060 12.022 1.00 43.01 ? 210 SER A N 1 ATOM 1639 C CA . SER A 1 210 ? 28.177 -17.802 10.983 1.00 42.61 ? 210 SER A CA 1 ATOM 1640 C C . SER A 1 210 ? 27.948 -19.002 10.060 1.00 50.63 ? 210 SER A C 1 ATOM 1641 O O . SER A 1 210 ? 26.918 -19.053 9.370 1.00 52.15 ? 210 SER A O 1 ATOM 1642 C CB . SER A 1 210 ? 28.549 -16.563 10.179 1.00 43.69 ? 210 SER A CB 1 ATOM 1643 O OG . SER A 1 210 ? 29.461 -16.855 9.134 1.00 49.70 ? 210 SER A OG 1 ATOM 1644 N N . LYS A 1 211 ? 28.902 -19.955 10.034 1.00 47.52 ? 211 LYS A N 1 ATOM 1645 C CA . LYS A 1 211 ? 28.814 -21.141 9.184 1.00 47.63 ? 211 LYS A CA 1 ATOM 1646 C C . LYS A 1 211 ? 28.142 -22.268 9.942 1.00 54.08 ? 211 LYS A C 1 ATOM 1647 O O . LYS A 1 211 ? 28.397 -22.421 11.141 1.00 55.17 ? 211 LYS A O 1 ATOM 1648 C CB . LYS A 1 211 ? 30.201 -21.596 8.671 1.00 48.97 ? 211 LYS A CB 1 ATOM 1649 C CG . LYS A 1 211 ? 31.102 -20.507 8.071 1.00 51.75 ? 211 LYS A CG 1 ATOM 1650 C CD . LYS A 1 211 ? 30.470 -19.722 6.915 1.00 48.31 ? 211 LYS A CD 1 ATOM 1651 C CE . LYS A 1 211 ? 31.166 -18.409 6.689 1.00 40.69 ? 211 LYS A CE 1 ATOM 1652 N NZ . LYS A 1 211 ? 30.350 -17.517 5.838 1.00 50.12 ? 211 LYS A NZ 1 ATOM 1653 N N . LYS A 1 212 ? 27.284 -23.059 9.242 1.00 49.82 ? 212 LYS A N 1 ATOM 1654 C CA . LYS A 1 212 ? 26.574 -24.223 9.796 1.00 49.03 ? 212 LYS A CA 1 ATOM 1655 C C . LYS A 1 212 ? 27.619 -25.277 10.143 1.00 52.65 ? 212 LYS A C 1 ATOM 1656 O O . LYS A 1 212 ? 27.805 -25.585 11.317 1.00 50.58 ? 212 LYS A O 1 ATOM 1657 C CB . LYS A 1 212 ? 25.523 -24.759 8.803 1.00 50.90 ? 212 LYS A CB 1 ATOM 1658 C CG . LYS A 1 212 ? 24.370 -23.788 8.535 1.00 61.41 ? 212 LYS A CG 1 ATOM 1659 C CD . LYS A 1 212 ? 23.763 -23.986 7.151 1.00 70.02 ? 212 LYS A CD 1 ATOM 1660 C CE . LYS A 1 212 ? 22.658 -23.000 6.865 1.00 82.13 ? 212 LYS A CE 1 ATOM 1661 N NZ . LYS A 1 212 ? 22.085 -23.201 5.506 1.00 88.90 ? 212 LYS A NZ 1 ATOM 1662 N N . ASN A 1 213 ? 28.361 -25.757 9.138 1.00 51.71 ? 213 ASN A N 1 ATOM 1663 C CA . ASN A 1 213 ? 29.463 -26.693 9.344 1.00 53.12 ? 213 ASN A CA 1 ATOM 1664 C C . ASN A 1 213 ? 30.730 -25.968 8.857 1.00 58.47 ? 213 ASN A C 1 ATOM 1665 O O . ASN A 1 213 ? 31.021 -25.980 7.655 1.00 59.44 ? 213 ASN A O 1 ATOM 1666 C CB . ASN A 1 213 ? 29.233 -28.023 8.619 1.00 57.19 ? 213 ASN A CB 1 ATOM 1667 C CG . ASN A 1 213 ? 27.970 -28.722 9.034 1.00 93.32 ? 213 ASN A CG 1 ATOM 1668 O OD1 . ASN A 1 213 ? 26.899 -28.472 8.490 1.00 93.25 ? 213 ASN A OD1 1 ATOM 1669 N ND2 . ASN A 1 213 ? 28.070 -29.622 10.003 1.00 88.31 ? 213 ASN A ND2 1 ATOM 1670 N N . PRO A 1 214 ? 31.432 -25.235 9.758 1.00 53.58 ? 214 PRO A N 1 ATOM 1671 C CA . PRO A 1 214 ? 32.586 -24.450 9.312 1.00 52.59 ? 214 PRO A CA 1 ATOM 1672 C C . PRO A 1 214 ? 33.796 -25.251 8.871 1.00 55.23 ? 214 PRO A C 1 ATOM 1673 O O . PRO A 1 214 ? 34.053 -26.362 9.348 1.00 55.86 ? 214 PRO A O 1 ATOM 1674 C CB . PRO A 1 214 ? 32.897 -23.569 10.519 1.00 54.53 ? 214 PRO A CB 1 ATOM 1675 C CG . PRO A 1 214 ? 32.428 -24.355 11.678 1.00 59.07 ? 214 PRO A CG 1 ATOM 1676 C CD . PRO A 1 214 ? 31.191 -25.051 11.205 1.00 54.95 ? 214 PRO A CD 1 ATOM 1677 N N . MET A 1 215 ? 34.521 -24.663 7.925 1.00 49.85 ? 215 MET A N 1 ATOM 1678 C CA . MET A 1 215 ? 35.758 -25.166 7.351 1.00 48.58 ? 215 MET A CA 1 ATOM 1679 C C . MET A 1 215 ? 36.577 -23.941 7.044 1.00 50.41 ? 215 MET A C 1 ATOM 1680 O O . MET A 1 215 ? 36.054 -22.947 6.537 1.00 48.10 ? 215 MET A O 1 ATOM 1681 C CB . MET A 1 215 ? 35.500 -25.973 6.069 1.00 50.62 ? 215 MET A CB 1 ATOM 1682 C CG . MET A 1 215 ? 36.666 -26.838 5.667 1.00 53.88 ? 215 MET A CG 1 ATOM 1683 S SD . MET A 1 215 ? 37.887 -25.954 4.688 1.00 57.69 ? 215 MET A SD 1 ATOM 1684 C CE . MET A 1 215 ? 37.265 -26.291 3.043 1.00 54.14 ? 215 MET A CE 1 ATOM 1685 N N . GLY A 1 216 ? 37.852 -24.024 7.369 1.00 47.43 ? 216 GLY A N 1 ATOM 1686 C CA . GLY A 1 216 ? 38.793 -22.944 7.128 1.00 47.04 ? 216 GLY A CA 1 ATOM 1687 C C . GLY A 1 216 ? 40.133 -23.453 6.647 1.00 48.93 ? 216 GLY A C 1 ATOM 1688 O O . GLY A 1 216 ? 40.520 -24.583 6.957 1.00 49.70 ? 216 GLY A O 1 ATOM 1689 N N . PHE A 1 217 ? 40.836 -22.633 5.864 1.00 41.58 ? 217 PHE A N 1 ATOM 1690 C CA . PHE A 1 217 ? 42.170 -22.950 5.365 1.00 39.82 ? 217 PHE A CA 1 ATOM 1691 C C . PHE A 1 217 ? 42.910 -21.659 5.136 1.00 43.42 ? 217 PHE A C 1 ATOM 1692 O O . PHE A 1 217 ? 42.296 -20.592 5.121 1.00 44.00 ? 217 PHE A O 1 ATOM 1693 C CB . PHE A 1 217 ? 42.122 -23.803 4.080 1.00 41.22 ? 217 PHE A CB 1 ATOM 1694 C CG . PHE A 1 217 ? 41.538 -23.123 2.857 1.00 42.28 ? 217 PHE A CG 1 ATOM 1695 C CD1 . PHE A 1 217 ? 40.157 -23.026 2.683 1.00 45.00 ? 217 PHE A CD1 1 ATOM 1696 C CD2 . PHE A 1 217 ? 42.366 -22.619 1.860 1.00 42.87 ? 217 PHE A CD2 1 ATOM 1697 C CE1 . PHE A 1 217 ? 39.620 -22.419 1.547 1.00 45.62 ? 217 PHE A CE1 1 ATOM 1698 C CE2 . PHE A 1 217 ? 41.829 -22.000 0.733 1.00 45.49 ? 217 PHE A CE2 1 ATOM 1699 C CZ . PHE A 1 217 ? 40.460 -21.902 0.584 1.00 44.34 ? 217 PHE A CZ 1 ATOM 1700 N N . SER A 1 218 ? 44.225 -21.745 4.987 1.00 39.20 ? 218 SER A N 1 ATOM 1701 C CA . SER A 1 218 ? 45.086 -20.612 4.688 1.00 38.36 ? 218 SER A CA 1 ATOM 1702 C C . SER A 1 218 ? 45.834 -20.956 3.406 1.00 42.50 ? 218 SER A C 1 ATOM 1703 O O . SER A 1 218 ? 45.992 -22.134 3.108 1.00 42.33 ? 218 SER A O 1 ATOM 1704 C CB . SER A 1 218 ? 46.037 -20.329 5.847 1.00 40.72 ? 218 SER A CB 1 ATOM 1705 O OG . SER A 1 218 ? 46.900 -21.420 6.107 1.00 49.97 ? 218 SER A OG 1 ATOM 1706 N N . TYR A 1 219 ? 46.237 -19.971 2.614 1.00 40.41 ? 219 TYR A N 1 ATOM 1707 C CA . TYR A 1 219 ? 46.946 -20.282 1.376 1.00 41.44 ? 219 TYR A CA 1 ATOM 1708 C C . TYR A 1 219 ? 48.273 -19.545 1.312 1.00 47.55 ? 219 TYR A C 1 ATOM 1709 O O . TYR A 1 219 ? 48.302 -18.312 1.343 1.00 47.20 ? 219 TYR A O 1 ATOM 1710 C CB . TYR A 1 219 ? 46.062 -20.028 0.138 1.00 43.12 ? 219 TYR A CB 1 ATOM 1711 C CG . TYR A 1 219 ? 46.642 -20.548 -1.158 1.00 45.94 ? 219 TYR A CG 1 ATOM 1712 C CD1 . TYR A 1 219 ? 46.538 -21.894 -1.499 1.00 48.29 ? 219 TYR A CD1 1 ATOM 1713 C CD2 . TYR A 1 219 ? 47.265 -19.690 -2.063 1.00 46.69 ? 219 TYR A CD2 1 ATOM 1714 C CE1 . TYR A 1 219 ? 47.062 -22.381 -2.696 1.00 49.44 ? 219 TYR A CE1 1 ATOM 1715 C CE2 . TYR A 1 219 ? 47.789 -20.165 -3.266 1.00 47.62 ? 219 TYR A CE2 1 ATOM 1716 C CZ . TYR A 1 219 ? 47.688 -21.515 -3.576 1.00 55.11 ? 219 TYR A CZ 1 ATOM 1717 O OH . TYR A 1 219 ? 48.202 -22.008 -4.751 1.00 54.08 ? 219 TYR A OH 1 ATOM 1718 N N . ASP A 1 220 ? 49.373 -20.315 1.282 1.00 45.85 ? 220 ASP A N 1 ATOM 1719 C CA . ASP A 1 220 ? 50.725 -19.776 1.227 1.00 47.11 ? 220 ASP A CA 1 ATOM 1720 C C . ASP A 1 220 ? 51.281 -19.846 -0.200 1.00 53.82 ? 220 ASP A C 1 ATOM 1721 O O . ASP A 1 220 ? 51.496 -20.947 -0.725 1.00 53.47 ? 220 ASP A O 1 ATOM 1722 C CB . ASP A 1 220 ? 51.651 -20.502 2.231 1.00 49.21 ? 220 ASP A CB 1 ATOM 1723 C CG . ASP A 1 220 ? 53.136 -20.223 2.012 1.00 63.67 ? 220 ASP A CG 1 ATOM 1724 O OD1 . ASP A 1 220 ? 53.541 -19.030 2.109 1.00 66.33 ? 220 ASP A OD1 1 ATOM 1725 O OD2 . ASP A 1 220 ? 53.884 -21.185 1.698 1.00 65.57 ? 220 ASP A OD2 1 ATOM 1726 N N . THR A 1 221 ? 51.516 -18.677 -0.829 1.00 52.13 ? 221 THR A N 1 ATOM 1727 C CA . THR A 1 221 ? 52.070 -18.672 -2.185 1.00 52.90 ? 221 THR A CA 1 ATOM 1728 C C . THR A 1 221 ? 53.574 -18.818 -2.092 1.00 58.57 ? 221 THR A C 1 ATOM 1729 O O . THR A 1 221 ? 54.230 -18.136 -1.277 1.00 58.72 ? 221 THR A O 1 ATOM 1730 C CB . THR A 1 221 ? 51.656 -17.434 -2.992 1.00 64.82 ? 221 THR A CB 1 ATOM 1731 O OG1 . THR A 1 221 ? 50.253 -17.203 -2.837 1.00 70.85 ? 221 THR A OG1 1 ATOM 1732 C CG2 . THR A 1 221 ? 51.997 -17.561 -4.480 1.00 61.14 ? 221 THR A CG2 1 ATOM 1733 N N . ARG A 1 222 ? 54.115 -19.746 -2.907 1.00 54.81 ? 222 ARG A N 1 ATOM 1734 C CA . ARG A 1 222 ? 55.549 -19.980 -2.977 1.00 54.23 ? 222 ARG A CA 1 ATOM 1735 C C . ARG A 1 222 ? 56.070 -18.704 -3.641 1.00 56.58 ? 222 ARG A C 1 ATOM 1736 O O . ARG A 1 222 ? 55.838 -18.508 -4.849 1.00 58.05 ? 222 ARG A O 1 ATOM 1737 C CB . ARG A 1 222 ? 55.855 -21.232 -3.819 1.00 54.91 ? 222 ARG A CB 1 ATOM 1738 C CG . ARG A 1 222 ? 57.295 -21.715 -3.695 1.00 70.34 ? 222 ARG A CG 1 ATOM 1739 C CD . ARG A 1 222 ? 57.643 -22.699 -4.800 1.00 91.34 ? 222 ARG A CD 1 ATOM 1740 N NE . ARG A 1 222 ? 57.942 -22.046 -6.084 1.00 105.35 ? 222 ARG A NE 1 ATOM 1741 C CZ . ARG A 1 222 ? 57.119 -22.010 -7.132 1.00 114.58 ? 222 ARG A CZ 1 ATOM 1742 N NH1 . ARG A 1 222 ? 55.917 -22.570 -7.062 1.00 102.50 ? 222 ARG A NH1 1 ATOM 1743 N NH2 . ARG A 1 222 ? 57.493 -21.411 -8.256 1.00 92.20 ? 222 ARG A NH2 1 ATOM 1744 N N A CYS A 1 223 ? 56.732 -17.826 -2.846 0.50 49.99 ? 223 CYS A N 1 ATOM 1745 N N B CYS A 1 223 ? 56.700 -17.809 -2.829 0.50 51.45 ? 223 CYS A N 1 ATOM 1746 C CA A CYS A 1 223 ? 57.280 -16.528 -3.261 0.50 48.09 ? 223 CYS A CA 1 ATOM 1747 C CA B CYS A 1 223 ? 57.261 -16.511 -3.227 0.50 50.28 ? 223 CYS A CA 1 ATOM 1748 C C A CYS A 1 223 ? 56.301 -15.733 -4.165 0.50 48.98 ? 223 CYS A C 1 ATOM 1749 C C B CYS A 1 223 ? 56.307 -15.718 -4.146 0.50 49.92 ? 223 CYS A C 1 ATOM 1750 O O A CYS A 1 223 ? 56.519 -15.646 -5.375 0.50 49.02 ? 223 CYS A O 1 ATOM 1751 O O B CYS A 1 223 ? 56.545 -15.627 -5.353 0.50 49.93 ? 223 CYS A O 1 ATOM 1752 C CB A CYS A 1 223 ? 58.683 -16.642 -3.874 0.50 48.07 ? 223 CYS A CB 1 ATOM 1753 C CB B CYS A 1 223 ? 58.657 -16.673 -3.835 0.50 51.04 ? 223 CYS A CB 1 ATOM 1754 S SG A CYS A 1 223 ? 59.111 -18.271 -4.562 0.50 51.56 ? 223 CYS A SG 1 ATOM 1755 S SG B CYS A 1 223 ? 60.012 -16.093 -2.772 0.50 55.08 ? 223 CYS A SG 1 ATOM 1756 N N . PHE A 1 224 ? 55.207 -15.190 -3.563 1.00 42.89 ? 224 PHE A N 1 ATOM 1757 C CA . PHE A 1 224 ? 54.126 -14.436 -4.244 1.00 40.58 ? 224 PHE A CA 1 ATOM 1758 C C . PHE A 1 224 ? 54.579 -13.361 -5.207 1.00 44.08 ? 224 PHE A C 1 ATOM 1759 O O . PHE A 1 224 ? 54.058 -13.296 -6.326 1.00 42.92 ? 224 PHE A O 1 ATOM 1760 C CB . PHE A 1 224 ? 53.139 -13.815 -3.233 1.00 41.35 ? 224 PHE A CB 1 ATOM 1761 C CG . PHE A 1 224 ? 51.863 -13.221 -3.819 1.00 41.25 ? 224 PHE A CG 1 ATOM 1762 C CD1 . PHE A 1 224 ? 51.801 -11.881 -4.187 1.00 41.83 ? 224 PHE A CD1 1 ATOM 1763 C CD2 . PHE A 1 224 ? 50.714 -13.993 -3.958 1.00 41.91 ? 224 PHE A CD2 1 ATOM 1764 C CE1 . PHE A 1 224 ? 50.627 -11.336 -4.710 1.00 41.38 ? 224 PHE A CE1 1 ATOM 1765 C CE2 . PHE A 1 224 ? 49.539 -13.442 -4.478 1.00 43.33 ? 224 PHE A CE2 1 ATOM 1766 C CZ . PHE A 1 224 ? 49.507 -12.119 -4.853 1.00 40.55 ? 224 PHE A CZ 1 ATOM 1767 N N . ASP A 1 225 ? 55.519 -12.501 -4.756 1.00 40.55 ? 225 ASP A N 1 ATOM 1768 C CA . ASP A 1 225 ? 56.069 -11.389 -5.532 1.00 39.74 ? 225 ASP A CA 1 ATOM 1769 C C . ASP A 1 225 ? 56.574 -11.882 -6.872 1.00 43.92 ? 225 ASP A C 1 ATOM 1770 O O . ASP A 1 225 ? 56.228 -11.290 -7.897 1.00 45.95 ? 225 ASP A O 1 ATOM 1771 C CB . ASP A 1 225 ? 57.186 -10.673 -4.753 1.00 41.24 ? 225 ASP A CB 1 ATOM 1772 C CG . ASP A 1 225 ? 56.736 -9.673 -3.698 1.00 51.39 ? 225 ASP A CG 1 ATOM 1773 O OD1 . ASP A 1 225 ? 55.514 -9.596 -3.423 1.00 51.87 ? 225 ASP A OD1 1 ATOM 1774 O OD2 . ASP A 1 225 ? 57.600 -8.942 -3.173 1.00 60.24 ? 225 ASP A OD2 1 ATOM 1775 N N . SER A 1 226 ? 57.311 -13.015 -6.874 1.00 37.51 ? 226 SER A N 1 ATOM 1776 C CA . SER A 1 226 ? 57.881 -13.648 -8.069 1.00 36.21 ? 226 SER A CA 1 ATOM 1777 C C . SER A 1 226 ? 56.836 -14.256 -9.010 1.00 36.57 ? 226 SER A C 1 ATOM 1778 O O . SER A 1 226 ? 57.155 -14.548 -10.166 1.00 34.64 ? 226 SER A O 1 ATOM 1779 C CB . SER A 1 226 ? 58.901 -14.709 -7.669 1.00 40.80 ? 226 SER A CB 1 ATOM 1780 O OG . SER A 1 226 ? 59.944 -14.127 -6.909 1.00 54.23 ? 226 SER A OG 1 ATOM 1781 N N . THR A 1 227 ? 55.601 -14.467 -8.516 1.00 32.24 ? 227 THR A N 1 ATOM 1782 C CA . THR A 1 227 ? 54.517 -15.020 -9.327 1.00 31.54 ? 227 THR A CA 1 ATOM 1783 C C . THR A 1 227 ? 53.679 -13.901 -9.981 1.00 37.65 ? 227 THR A C 1 ATOM 1784 O O . THR A 1 227 ? 52.925 -14.174 -10.914 1.00 38.75 ? 227 THR A O 1 ATOM 1785 C CB . THR A 1 227 ? 53.671 -16.035 -8.557 1.00 29.22 ? 227 THR A CB 1 ATOM 1786 O OG1 . THR A 1 227 ? 52.606 -15.346 -7.895 1.00 28.29 ? 227 THR A OG1 1 ATOM 1787 C CG2 . THR A 1 227 ? 54.500 -16.956 -7.604 1.00 19.10 ? 227 THR A CG2 1 ATOM 1788 N N . VAL A 1 228 ? 53.825 -12.650 -9.505 1.00 34.51 ? 228 VAL A N 1 ATOM 1789 C CA . VAL A 1 228 ? 53.125 -11.483 -10.041 1.00 34.36 ? 228 VAL A CA 1 ATOM 1790 C C . VAL A 1 228 ? 53.712 -11.183 -11.433 1.00 37.86 ? 228 VAL A C 1 ATOM 1791 O O . VAL A 1 228 ? 54.921 -11.039 -11.580 1.00 36.97 ? 228 VAL A O 1 ATOM 1792 C CB . VAL A 1 228 ? 53.148 -10.277 -9.061 1.00 37.94 ? 228 VAL A CB 1 ATOM 1793 C CG1 . VAL A 1 228 ? 52.426 -9.067 -9.642 1.00 37.88 ? 228 VAL A CG1 1 ATOM 1794 C CG2 . VAL A 1 228 ? 52.540 -10.654 -7.716 1.00 37.35 ? 228 VAL A CG2 1 ATOM 1795 N N . THR A 1 229 ? 52.839 -11.181 -12.450 1.00 33.76 ? 229 THR A N 1 ATOM 1796 C CA . THR A 1 229 ? 53.159 -11.013 -13.868 1.00 32.37 ? 229 THR A CA 1 ATOM 1797 C C . THR A 1 229 ? 52.808 -9.610 -14.335 1.00 36.45 ? 229 THR A C 1 ATOM 1798 O O . THR A 1 229 ? 52.069 -8.923 -13.646 1.00 37.35 ? 229 THR A O 1 ATOM 1799 C CB . THR A 1 229 ? 52.331 -12.024 -14.679 1.00 31.18 ? 229 THR A CB 1 ATOM 1800 O OG1 . THR A 1 229 ? 50.966 -11.667 -14.558 1.00 26.79 ? 229 THR A OG1 1 ATOM 1801 C CG2 . THR A 1 229 ? 52.503 -13.464 -14.207 1.00 26.80 ? 229 THR A CG2 1 ATOM 1802 N N . GLU A 1 230 ? 53.283 -9.202 -15.538 1.00 32.78 ? 230 GLU A N 1 ATOM 1803 C CA . GLU A 1 230 ? 52.951 -7.904 -16.161 1.00 31.69 ? 230 GLU A CA 1 ATOM 1804 C C . GLU A 1 230 ? 51.441 -7.689 -16.151 1.00 36.09 ? 230 GLU A C 1 ATOM 1805 O O . GLU A 1 230 ? 50.985 -6.612 -15.790 1.00 36.85 ? 230 GLU A O 1 ATOM 1806 C CB . GLU A 1 230 ? 53.457 -7.835 -17.617 1.00 32.33 ? 230 GLU A CB 1 ATOM 1807 C CG . GLU A 1 230 ? 53.304 -6.461 -18.251 1.00 35.58 ? 230 GLU A CG 1 ATOM 1808 C CD . GLU A 1 230 ? 53.952 -6.261 -19.606 1.00 47.53 ? 230 GLU A CD 1 ATOM 1809 O OE1 . GLU A 1 230 ? 54.996 -6.895 -19.878 1.00 37.30 ? 230 GLU A OE1 1 ATOM 1810 O OE2 . GLU A 1 230 ? 53.434 -5.433 -20.388 1.00 41.30 ? 230 GLU A OE2 1 ATOM 1811 N N . ASN A 1 231 ? 50.674 -8.734 -16.518 1.00 31.83 ? 231 ASN A N 1 ATOM 1812 C CA . ASN A 1 231 ? 49.224 -8.706 -16.536 1.00 30.98 ? 231 ASN A CA 1 ATOM 1813 C C . ASN A 1 231 ? 48.686 -8.205 -15.207 1.00 35.66 ? 231 ASN A C 1 ATOM 1814 O O . ASN A 1 231 ? 47.951 -7.219 -15.193 1.00 35.48 ? 231 ASN A O 1 ATOM 1815 C CB . ASN A 1 231 ? 48.638 -10.081 -16.875 1.00 27.97 ? 231 ASN A CB 1 ATOM 1816 C CG . ASN A 1 231 ? 47.136 -10.065 -16.762 1.00 46.25 ? 231 ASN A CG 1 ATOM 1817 O OD1 . ASN A 1 231 ? 46.447 -9.379 -17.541 1.00 35.56 ? 231 ASN A OD1 1 ATOM 1818 N ND2 . ASN A 1 231 ? 46.620 -10.681 -15.691 1.00 35.29 ? 231 ASN A ND2 1 ATOM 1819 N N . ASP A 1 232 ? 49.094 -8.866 -14.097 1.00 32.08 ? 232 ASP A N 1 ATOM 1820 C CA . ASP A 1 232 ? 48.688 -8.549 -12.725 1.00 31.02 ? 232 ASP A CA 1 ATOM 1821 C C . ASP A 1 232 ? 48.958 -7.105 -12.352 1.00 33.07 ? 232 ASP A C 1 ATOM 1822 O O . ASP A 1 232 ? 48.105 -6.475 -11.733 1.00 33.68 ? 232 ASP A O 1 ATOM 1823 C CB . ASP A 1 232 ? 49.361 -9.492 -11.712 1.00 32.12 ? 232 ASP A CB 1 ATOM 1824 C CG . ASP A 1 232 ? 49.143 -10.977 -11.942 1.00 35.84 ? 232 ASP A CG 1 ATOM 1825 O OD1 . ASP A 1 232 ? 48.019 -11.364 -12.347 1.00 34.50 ? 232 ASP A OD1 1 ATOM 1826 O OD2 . ASP A 1 232 ? 50.062 -11.756 -11.641 1.00 40.49 ? 232 ASP A OD2 1 ATOM 1827 N N . ILE A 1 233 ? 50.108 -6.570 -12.757 1.00 29.02 ? 233 ILE A N 1 ATOM 1828 C CA . ILE A 1 233 ? 50.491 -5.185 -12.442 1.00 29.78 ? 233 ILE A CA 1 ATOM 1829 C C . ILE A 1 233 ? 49.660 -4.156 -13.274 1.00 34.24 ? 233 ILE A C 1 ATOM 1830 O O . ILE A 1 233 ? 49.295 -3.101 -12.743 1.00 33.52 ? 233 ILE A O 1 ATOM 1831 C CB . ILE A 1 233 ? 52.032 -4.986 -12.532 1.00 32.33 ? 233 ILE A CB 1 ATOM 1832 C CG1 . ILE A 1 233 ? 52.746 -5.879 -11.470 1.00 31.77 ? 233 ILE A CG1 1 ATOM 1833 C CG2 . ILE A 1 233 ? 52.411 -3.516 -12.325 1.00 32.41 ? 233 ILE A CG2 1 ATOM 1834 C CD1 . ILE A 1 233 ? 54.033 -6.575 -11.945 1.00 35.53 ? 233 ILE A CD1 1 ATOM 1835 N N . ARG A 1 234 ? 49.319 -4.499 -14.539 1.00 30.82 ? 234 ARG A N 1 ATOM 1836 C CA . ARG A 1 234 ? 48.495 -3.667 -15.427 1.00 30.24 ? 234 ARG A CA 1 ATOM 1837 C C . ARG A 1 234 ? 47.040 -3.704 -14.941 1.00 36.53 ? 234 ARG A C 1 ATOM 1838 O O . ARG A 1 234 ? 46.351 -2.683 -14.977 1.00 38.63 ? 234 ARG A O 1 ATOM 1839 C CB . ARG A 1 234 ? 48.574 -4.162 -16.870 1.00 26.83 ? 234 ARG A CB 1 ATOM 1840 C CG . ARG A 1 234 ? 49.968 -4.156 -17.457 1.00 26.14 ? 234 ARG A CG 1 ATOM 1841 C CD . ARG A 1 234 ? 49.923 -4.164 -18.967 1.00 28.21 ? 234 ARG A CD 1 ATOM 1842 N NE . ARG A 1 234 ? 51.244 -3.951 -19.553 1.00 31.11 ? 234 ARG A NE 1 ATOM 1843 C CZ . ARG A 1 234 ? 51.785 -2.757 -19.779 1.00 44.42 ? 234 ARG A CZ 1 ATOM 1844 N NH1 . ARG A 1 234 ? 51.133 -1.650 -19.441 1.00 27.72 ? 234 ARG A NH1 1 ATOM 1845 N NH2 . ARG A 1 234 ? 53.001 -2.661 -20.298 1.00 33.07 ? 234 ARG A NH2 1 ATOM 1846 N N . VAL A 1 235 ? 46.589 -4.881 -14.462 1.00 30.89 ? 235 VAL A N 1 ATOM 1847 C CA . VAL A 1 235 ? 45.263 -5.093 -13.904 1.00 29.19 ? 235 VAL A CA 1 ATOM 1848 C C . VAL A 1 235 ? 45.101 -4.158 -12.708 1.00 32.44 ? 235 VAL A C 1 ATOM 1849 O O . VAL A 1 235 ? 44.122 -3.410 -12.663 1.00 33.07 ? 235 VAL A O 1 ATOM 1850 C CB . VAL A 1 235 ? 45.002 -6.601 -13.591 1.00 32.34 ? 235 VAL A CB 1 ATOM 1851 C CG1 . VAL A 1 235 ? 43.885 -6.788 -12.574 1.00 32.01 ? 235 VAL A CG1 1 ATOM 1852 C CG2 . VAL A 1 235 ? 44.683 -7.373 -14.870 1.00 31.69 ? 235 VAL A CG2 1 ATOM 1853 N N . GLU A 1 236 ? 46.094 -4.157 -11.782 1.00 28.35 ? 236 GLU A N 1 ATOM 1854 C CA . GLU A 1 236 ? 46.170 -3.297 -10.597 1.00 27.46 ? 236 GLU A CA 1 ATOM 1855 C C . GLU A 1 236 ? 46.029 -1.828 -10.991 1.00 31.76 ? 236 GLU A C 1 ATOM 1856 O O . GLU A 1 236 ? 45.237 -1.114 -10.370 1.00 30.81 ? 236 GLU A O 1 ATOM 1857 C CB . GLU A 1 236 ? 47.526 -3.469 -9.919 1.00 28.98 ? 236 GLU A CB 1 ATOM 1858 C CG . GLU A 1 236 ? 47.645 -4.683 -9.022 1.00 40.34 ? 236 GLU A CG 1 ATOM 1859 C CD . GLU A 1 236 ? 49.071 -5.124 -8.758 1.00 53.96 ? 236 GLU A CD 1 ATOM 1860 O OE1 . GLU A 1 236 ? 49.954 -4.260 -8.543 1.00 49.53 ? 236 GLU A OE1 1 ATOM 1861 O OE2 . GLU A 1 236 ? 49.298 -6.354 -8.739 1.00 32.26 ? 236 GLU A OE2 1 ATOM 1862 N N . GLU A 1 237 ? 46.797 -1.378 -12.034 1.00 28.74 ? 237 GLU A N 1 ATOM 1863 C CA . GLU A 1 237 ? 46.777 -0.008 -12.544 1.00 29.11 ? 237 GLU A CA 1 ATOM 1864 C C . GLU A 1 237 ? 45.382 0.350 -13.000 1.00 33.80 ? 237 GLU A C 1 ATOM 1865 O O . GLU A 1 237 ? 44.863 1.390 -12.588 1.00 33.33 ? 237 GLU A O 1 ATOM 1866 C CB . GLU A 1 237 ? 47.774 0.171 -13.693 1.00 31.06 ? 237 GLU A CB 1 ATOM 1867 C CG . GLU A 1 237 ? 48.057 1.630 -14.058 1.00 39.62 ? 237 GLU A CG 1 ATOM 1868 C CD . GLU A 1 237 ? 47.431 2.120 -15.348 1.00 61.13 ? 237 GLU A CD 1 ATOM 1869 O OE1 . GLU A 1 237 ? 46.856 1.293 -16.095 1.00 58.87 ? 237 GLU A OE1 1 ATOM 1870 O OE2 . GLU A 1 237 ? 47.525 3.340 -15.614 1.00 56.51 ? 237 GLU A OE2 1 ATOM 1871 N N . SER A 1 238 ? 44.753 -0.538 -13.802 1.00 30.92 ? 238 SER A N 1 ATOM 1872 C CA . SER A 1 238 ? 43.382 -0.353 -14.282 1.00 31.15 ? 238 SER A CA 1 ATOM 1873 C C . SER A 1 238 ? 42.394 -0.195 -13.115 1.00 35.45 ? 238 SER A C 1 ATOM 1874 O O . SER A 1 238 ? 41.449 0.600 -13.229 1.00 36.07 ? 238 SER A O 1 ATOM 1875 C CB . SER A 1 238 ? 42.967 -1.473 -15.236 1.00 34.16 ? 238 SER A CB 1 ATOM 1876 O OG . SER A 1 238 ? 42.410 -2.592 -14.570 1.00 43.84 ? 238 SER A OG 1 ATOM 1877 N N . ILE A 1 239 ? 42.640 -0.917 -11.985 1.00 30.53 ? 239 ILE A N 1 ATOM 1878 C CA . ILE A 1 239 ? 41.824 -0.813 -10.767 1.00 29.62 ? 239 ILE A CA 1 ATOM 1879 C C . ILE A 1 239 ? 42.016 0.592 -10.189 1.00 33.49 ? 239 ILE A C 1 ATOM 1880 O O . ILE A 1 239 ? 41.034 1.309 -10.008 1.00 32.27 ? 239 ILE A O 1 ATOM 1881 C CB . ILE A 1 239 ? 42.112 -1.947 -9.731 1.00 31.81 ? 239 ILE A CB 1 ATOM 1882 C CG1 . ILE A 1 239 ? 41.713 -3.331 -10.278 1.00 31.31 ? 239 ILE A CG1 1 ATOM 1883 C CG2 . ILE A 1 239 ? 41.430 -1.659 -8.376 1.00 31.88 ? 239 ILE A CG2 1 ATOM 1884 C CD1 . ILE A 1 239 ? 42.436 -4.554 -9.612 1.00 30.73 ? 239 ILE A CD1 1 ATOM 1885 N N . TYR A 1 240 ? 43.286 1.004 -9.963 1.00 32.40 ? 240 TYR A N 1 ATOM 1886 C CA . TYR A 1 240 ? 43.630 2.346 -9.445 1.00 33.36 ? 240 TYR A CA 1 ATOM 1887 C C . TYR A 1 240 ? 42.978 3.435 -10.313 1.00 38.68 ? 240 TYR A C 1 ATOM 1888 O O . TYR A 1 240 ? 42.342 4.338 -9.787 1.00 37.86 ? 240 TYR A O 1 ATOM 1889 C CB . TYR A 1 240 ? 45.157 2.579 -9.415 1.00 34.43 ? 240 TYR A CB 1 ATOM 1890 C CG . TYR A 1 240 ? 46.001 1.536 -8.702 1.00 35.38 ? 240 TYR A CG 1 ATOM 1891 C CD1 . TYR A 1 240 ? 45.517 0.858 -7.586 1.00 36.64 ? 240 TYR A CD1 1 ATOM 1892 C CD2 . TYR A 1 240 ? 47.323 1.314 -9.074 1.00 36.28 ? 240 TYR A CD2 1 ATOM 1893 C CE1 . TYR A 1 240 ? 46.300 -0.074 -6.908 1.00 37.62 ? 240 TYR A CE1 1 ATOM 1894 C CE2 . TYR A 1 240 ? 48.117 0.386 -8.405 1.00 37.68 ? 240 TYR A CE2 1 ATOM 1895 C CZ . TYR A 1 240 ? 47.600 -0.312 -7.323 1.00 48.69 ? 240 TYR A CZ 1 ATOM 1896 O OH . TYR A 1 240 ? 48.383 -1.237 -6.664 1.00 52.27 ? 240 TYR A OH 1 ATOM 1897 N N . GLN A 1 241 ? 43.067 3.278 -11.645 1.00 36.89 ? 241 GLN A N 1 ATOM 1898 C CA . GLN A 1 241 ? 42.522 4.190 -12.654 1.00 36.64 ? 241 GLN A CA 1 ATOM 1899 C C . GLN A 1 241 ? 41.007 4.339 -12.603 1.00 41.42 ? 241 GLN A C 1 ATOM 1900 O O . GLN A 1 241 ? 40.500 5.300 -13.180 1.00 42.16 ? 241 GLN A O 1 ATOM 1901 C CB . GLN A 1 241 ? 42.995 3.814 -14.070 1.00 37.58 ? 241 GLN A CB 1 ATOM 1902 C CG . GLN A 1 241 ? 44.487 4.098 -14.304 1.00 38.09 ? 241 GLN A CG 1 ATOM 1903 C CD . GLN A 1 241 ? 44.865 5.569 -14.295 1.00 51.99 ? 241 GLN A CD 1 ATOM 1904 O OE1 . GLN A 1 241 ? 44.046 6.463 -14.528 1.00 52.51 ? 241 GLN A OE1 1 ATOM 1905 N NE2 . GLN A 1 241 ? 46.134 5.853 -14.063 1.00 38.10 ? 241 GLN A NE2 1 ATOM 1906 N N . CYS A 1 242 ? 40.282 3.442 -11.889 1.00 37.23 ? 242 CYS A N 1 ATOM 1907 C CA . CYS A 1 242 ? 38.829 3.578 -11.742 1.00 36.40 ? 242 CYS A CA 1 ATOM 1908 C C . CYS A 1 242 ? 38.484 4.712 -10.794 1.00 39.13 ? 242 CYS A C 1 ATOM 1909 O O . CYS A 1 242 ? 37.408 5.285 -10.934 1.00 39.14 ? 242 CYS A O 1 ATOM 1910 C CB . CYS A 1 242 ? 38.181 2.272 -11.297 1.00 36.69 ? 242 CYS A CB 1 ATOM 1911 S SG . CYS A 1 242 ? 38.303 0.941 -12.508 1.00 40.67 ? 242 CYS A SG 1 ATOM 1912 N N . CYS A 1 243 ? 39.389 5.029 -9.828 1.00 34.29 ? 243 CYS A N 1 ATOM 1913 C CA . CYS A 1 243 ? 39.225 6.091 -8.821 1.00 33.47 ? 243 CYS A CA 1 ATOM 1914 C C . CYS A 1 243 ? 39.016 7.447 -9.453 1.00 37.53 ? 243 CYS A C 1 ATOM 1915 O O . CYS A 1 243 ? 39.479 7.678 -10.576 1.00 38.06 ? 243 CYS A O 1 ATOM 1916 C CB . CYS A 1 243 ? 40.434 6.147 -7.892 1.00 33.56 ? 243 CYS A CB 1 ATOM 1917 S SG . CYS A 1 243 ? 40.687 4.674 -6.888 1.00 37.48 ? 243 CYS A SG 1 ATOM 1918 N N . ASP A 1 244 ? 38.405 8.377 -8.689 1.00 32.85 ? 244 ASP A N 1 ATOM 1919 C CA . ASP A 1 244 ? 38.289 9.784 -9.064 1.00 32.50 ? 244 ASP A CA 1 ATOM 1920 C C . ASP A 1 244 ? 39.673 10.302 -8.669 1.00 34.26 ? 244 ASP A C 1 ATOM 1921 O O . ASP A 1 244 ? 40.028 10.314 -7.485 1.00 32.61 ? 244 ASP A O 1 ATOM 1922 C CB . ASP A 1 244 ? 37.172 10.489 -8.255 1.00 35.23 ? 244 ASP A CB 1 ATOM 1923 C CG . ASP A 1 244 ? 36.896 11.956 -8.562 1.00 47.10 ? 244 ASP A CG 1 ATOM 1924 O OD1 . ASP A 1 244 ? 37.842 12.679 -8.933 1.00 47.69 ? 244 ASP A OD1 1 ATOM 1925 O OD2 . ASP A 1 244 ? 35.743 12.394 -8.368 1.00 56.92 ? 244 ASP A OD2 1 ATOM 1926 N N . LEU A 1 245 ? 40.489 10.604 -9.681 1.00 31.01 ? 245 LEU A N 1 ATOM 1927 C CA . LEU A 1 245 ? 41.871 11.032 -9.514 1.00 30.72 ? 245 LEU A CA 1 ATOM 1928 C C . LEU A 1 245 ? 42.161 12.339 -10.226 1.00 35.95 ? 245 LEU A C 1 ATOM 1929 O O . LEU A 1 245 ? 41.516 12.671 -11.218 1.00 36.72 ? 245 LEU A O 1 ATOM 1930 C CB . LEU A 1 245 ? 42.809 9.958 -10.086 1.00 30.59 ? 245 LEU A CB 1 ATOM 1931 C CG . LEU A 1 245 ? 42.916 8.637 -9.343 1.00 35.18 ? 245 LEU A CG 1 ATOM 1932 C CD1 . LEU A 1 245 ? 43.416 7.547 -10.277 1.00 35.26 ? 245 LEU A CD1 1 ATOM 1933 C CD2 . LEU A 1 245 ? 43.823 8.762 -8.099 1.00 36.71 ? 245 LEU A CD2 1 ATOM 1934 N N . ALA A 1 246 ? 43.183 13.053 -9.745 1.00 32.60 ? 246 ALA A N 1 ATOM 1935 C CA . ALA A 1 246 ? 43.652 14.285 -10.350 1.00 32.41 ? 246 ALA A CA 1 ATOM 1936 C C . ALA A 1 246 ? 44.346 13.873 -11.666 1.00 36.98 ? 246 ALA A C 1 ATOM 1937 O O . ALA A 1 246 ? 44.952 12.804 -11.699 1.00 37.00 ? 246 ALA A O 1 ATOM 1938 C CB . ALA A 1 246 ? 44.649 14.952 -9.413 1.00 33.27 ? 246 ALA A CB 1 ATOM 1939 N N . PRO A 1 247 ? 44.252 14.654 -12.764 1.00 33.76 ? 247 PRO A N 1 ATOM 1940 C CA . PRO A 1 247 ? 44.917 14.246 -14.026 1.00 33.60 ? 247 PRO A CA 1 ATOM 1941 C C . PRO A 1 247 ? 46.419 13.972 -13.892 1.00 37.52 ? 247 PRO A C 1 ATOM 1942 O O . PRO A 1 247 ? 46.948 13.072 -14.552 1.00 37.70 ? 247 PRO A O 1 ATOM 1943 C CB . PRO A 1 247 ? 44.662 15.432 -14.952 1.00 35.27 ? 247 PRO A CB 1 ATOM 1944 C CG . PRO A 1 247 ? 43.460 16.103 -14.387 1.00 39.53 ? 247 PRO A CG 1 ATOM 1945 C CD . PRO A 1 247 ? 43.574 15.954 -12.912 1.00 35.03 ? 247 PRO A CD 1 ATOM 1946 N N . GLU A 1 248 ? 47.095 14.740 -13.017 1.00 33.88 ? 248 GLU A N 1 ATOM 1947 C CA . GLU A 1 248 ? 48.516 14.599 -12.721 1.00 33.71 ? 248 GLU A CA 1 ATOM 1948 C C . GLU A 1 248 ? 48.737 13.208 -12.113 1.00 38.52 ? 248 GLU A C 1 ATOM 1949 O O . GLU A 1 248 ? 49.608 12.466 -12.590 1.00 40.27 ? 248 GLU A O 1 ATOM 1950 C CB . GLU A 1 248 ? 48.974 15.703 -11.751 1.00 34.95 ? 248 GLU A CB 1 ATOM 1951 C CG . GLU A 1 248 ? 49.458 16.957 -12.457 1.00 48.96 ? 248 GLU A CG 1 ATOM 1952 C CD . GLU A 1 248 ? 50.592 17.734 -11.799 1.00 78.53 ? 248 GLU A CD 1 ATOM 1953 O OE1 . GLU A 1 248 ? 51.082 17.306 -10.728 1.00 71.96 ? 248 GLU A OE1 1 ATOM 1954 O OE2 . GLU A 1 248 ? 51.002 18.772 -12.370 1.00 72.05 ? 248 GLU A OE2 1 ATOM 1955 N N . ALA A 1 249 ? 47.876 12.831 -11.124 1.00 31.63 ? 249 ALA A N 1 ATOM 1956 C CA . ALA A 1 249 ? 47.891 11.539 -10.446 1.00 29.91 ? 249 ALA A CA 1 ATOM 1957 C C . ALA A 1 249 ? 47.723 10.371 -11.407 1.00 33.11 ? 249 ALA A C 1 ATOM 1958 O O . ALA A 1 249 ? 48.536 9.461 -11.339 1.00 33.81 ? 249 ALA A O 1 ATOM 1959 C CB . ALA A 1 249 ? 46.828 11.492 -9.371 1.00 30.52 ? 249 ALA A CB 1 ATOM 1960 N N . ARG A 1 250 ? 46.715 10.403 -12.321 1.00 28.54 ? 250 ARG A N 1 ATOM 1961 C CA . ARG A 1 250 ? 46.481 9.365 -13.336 1.00 28.87 ? 250 ARG A CA 1 ATOM 1962 C C . ARG A 1 250 ? 47.747 9.124 -14.134 1.00 36.25 ? 250 ARG A C 1 ATOM 1963 O O . ARG A 1 250 ? 48.204 7.982 -14.248 1.00 35.98 ? 250 ARG A O 1 ATOM 1964 C CB . ARG A 1 250 ? 45.396 9.781 -14.336 1.00 28.39 ? 250 ARG A CB 1 ATOM 1965 C CG . ARG A 1 250 ? 44.058 10.050 -13.732 1.00 36.45 ? 250 ARG A CG 1 ATOM 1966 C CD . ARG A 1 250 ? 42.961 9.883 -14.746 1.00 29.54 ? 250 ARG A CD 1 ATOM 1967 N NE . ARG A 1 250 ? 41.665 10.022 -14.084 1.00 39.39 ? 250 ARG A NE 1 ATOM 1968 C CZ . ARG A 1 250 ? 41.034 9.033 -13.454 1.00 52.37 ? 250 ARG A CZ 1 ATOM 1969 N NH1 . ARG A 1 250 ? 41.564 7.815 -13.414 1.00 28.28 ? 250 ARG A NH1 1 ATOM 1970 N NH2 . ARG A 1 250 ? 39.867 9.254 -12.860 1.00 43.76 ? 250 ARG A NH2 1 ATOM 1971 N N . GLN A 1 251 ? 48.310 10.225 -14.682 1.00 35.21 ? 251 GLN A N 1 ATOM 1972 C CA . GLN A 1 251 ? 49.533 10.229 -15.477 1.00 35.13 ? 251 GLN A CA 1 ATOM 1973 C C . GLN A 1 251 ? 50.680 9.639 -14.686 1.00 37.29 ? 251 GLN A C 1 ATOM 1974 O O . GLN A 1 251 ? 51.382 8.777 -15.211 1.00 36.69 ? 251 GLN A O 1 ATOM 1975 C CB . GLN A 1 251 ? 49.874 11.652 -15.964 1.00 36.42 ? 251 GLN A CB 1 ATOM 1976 C CG . GLN A 1 251 ? 51.175 11.744 -16.784 1.00 37.05 ? 251 GLN A CG 1 ATOM 1977 C CD . GLN A 1 251 ? 51.067 11.243 -18.197 1.00 42.01 ? 251 GLN A CD 1 ATOM 1978 O OE1 . GLN A 1 251 ? 50.245 10.391 -18.532 1.00 34.82 ? 251 GLN A OE1 1 ATOM 1979 N NE2 . GLN A 1 251 ? 51.906 11.777 -19.064 1.00 39.61 ? 251 GLN A NE2 1 ATOM 1980 N N . ALA A 1 252 ? 50.851 10.091 -13.425 1.00 32.90 ? 252 ALA A N 1 ATOM 1981 C CA . ALA A 1 252 ? 51.894 9.600 -12.537 1.00 32.32 ? 252 ALA A CA 1 ATOM 1982 C C . ALA A 1 252 ? 51.724 8.093 -12.278 1.00 37.22 ? 252 ALA A C 1 ATOM 1983 O O . ALA A 1 252 ? 52.726 7.370 -12.306 1.00 37.28 ? 252 ALA A O 1 ATOM 1984 C CB . ALA A 1 252 ? 51.883 10.375 -11.239 1.00 32.68 ? 252 ALA A CB 1 ATOM 1985 N N . ILE A 1 253 ? 50.461 7.612 -12.101 1.00 33.47 ? 253 ILE A N 1 ATOM 1986 C CA . ILE A 1 253 ? 50.167 6.190 -11.865 1.00 33.49 ? 253 ILE A CA 1 ATOM 1987 C C . ILE A 1 253 ? 50.571 5.375 -13.095 1.00 37.03 ? 253 ILE A C 1 ATOM 1988 O O . ILE A 1 253 ? 51.278 4.374 -12.947 1.00 36.80 ? 253 ILE A O 1 ATOM 1989 C CB . ILE A 1 253 ? 48.708 5.930 -11.365 1.00 36.75 ? 253 ILE A CB 1 ATOM 1990 C CG1 . ILE A 1 253 ? 48.520 6.530 -9.951 1.00 37.51 ? 253 ILE A CG1 1 ATOM 1991 C CG2 . ILE A 1 253 ? 48.371 4.431 -11.327 1.00 37.61 ? 253 ILE A CG2 1 ATOM 1992 C CD1 . ILE A 1 253 ? 47.085 6.909 -9.538 1.00 44.40 ? 253 ILE A CD1 1 ATOM 1993 N N . LYS A 1 254 ? 50.199 5.859 -14.301 1.00 32.93 ? 254 LYS A N 1 ATOM 1994 C CA . LYS A 1 254 ? 50.511 5.223 -15.587 1.00 32.36 ? 254 LYS A CA 1 ATOM 1995 C C . LYS A 1 254 ? 52.024 5.085 -15.803 1.00 36.32 ? 254 LYS A C 1 ATOM 1996 O O . LYS A 1 254 ? 52.475 4.010 -16.219 1.00 36.87 ? 254 LYS A O 1 ATOM 1997 C CB . LYS A 1 254 ? 49.863 5.981 -16.757 1.00 34.36 ? 254 LYS A CB 1 ATOM 1998 C CG . LYS A 1 254 ? 49.676 5.097 -17.974 1.00 51.79 ? 254 LYS A CG 1 ATOM 1999 C CD . LYS A 1 254 ? 49.945 5.834 -19.271 1.00 63.00 ? 254 LYS A CD 1 ATOM 2000 C CE . LYS A 1 254 ? 49.820 4.917 -20.474 1.00 77.20 ? 254 LYS A CE 1 ATOM 2001 N NZ . LYS A 1 254 ? 50.915 3.904 -20.548 1.00 85.87 ? 254 LYS A NZ 1 ATOM 2002 N N . SER A 1 255 ? 52.800 6.172 -15.529 1.00 30.19 ? 255 SER A N 1 ATOM 2003 C CA . SER A 1 255 ? 54.258 6.192 -15.641 1.00 28.55 ? 255 SER A CA 1 ATOM 2004 C C . SER A 1 255 ? 54.892 5.293 -14.562 1.00 31.57 ? 255 SER A C 1 ATOM 2005 O O . SER A 1 255 ? 55.712 4.458 -14.905 1.00 31.63 ? 255 SER A O 1 ATOM 2006 C CB . SER A 1 255 ? 54.791 7.611 -15.518 1.00 30.92 ? 255 SER A CB 1 ATOM 2007 O OG . SER A 1 255 ? 54.063 8.488 -16.355 1.00 40.92 ? 255 SER A OG 1 ATOM 2008 N N . LEU A 1 256 ? 54.477 5.408 -13.288 1.00 26.64 ? 256 LEU A N 1 ATOM 2009 C CA . LEU A 1 256 ? 55.019 4.540 -12.241 1.00 26.49 ? 256 LEU A CA 1 ATOM 2010 C C . LEU A 1 256 ? 54.744 3.075 -12.544 1.00 29.29 ? 256 LEU A C 1 ATOM 2011 O O . LEU A 1 256 ? 55.603 2.243 -12.296 1.00 30.32 ? 256 LEU A O 1 ATOM 2012 C CB . LEU A 1 256 ? 54.507 4.920 -10.831 1.00 26.50 ? 256 LEU A CB 1 ATOM 2013 C CG . LEU A 1 256 ? 55.099 6.193 -10.234 1.00 30.04 ? 256 LEU A CG 1 ATOM 2014 C CD1 . LEU A 1 256 ? 54.174 6.778 -9.199 1.00 29.66 ? 256 LEU A CD1 1 ATOM 2015 C CD2 . LEU A 1 256 ? 56.497 5.954 -9.692 1.00 30.99 ? 256 LEU A CD2 1 ATOM 2016 N N . THR A 1 257 ? 53.586 2.758 -13.120 1.00 24.56 ? 257 THR A N 1 ATOM 2017 C CA . THR A 1 257 ? 53.278 1.378 -13.487 1.00 24.85 ? 257 THR A CA 1 ATOM 2018 C C . THR A 1 257 ? 54.207 0.880 -14.612 1.00 32.63 ? 257 THR A C 1 ATOM 2019 O O . THR A 1 257 ? 54.947 -0.086 -14.407 1.00 33.46 ? 257 THR A O 1 ATOM 2020 C CB . THR A 1 257 ? 51.797 1.230 -13.809 1.00 23.42 ? 257 THR A CB 1 ATOM 2021 O OG1 . THR A 1 257 ? 51.078 1.497 -12.615 1.00 20.09 ? 257 THR A OG1 1 ATOM 2022 C CG2 . THR A 1 257 ? 51.445 -0.152 -14.350 1.00 18.05 ? 257 THR A CG2 1 ATOM 2023 N N . GLU A 1 258 ? 54.165 1.558 -15.777 1.00 29.36 ? 258 GLU A N 1 ATOM 2024 C CA . GLU A 1 258 ? 54.940 1.248 -16.965 1.00 29.06 ? 258 GLU A CA 1 ATOM 2025 C C . GLU A 1 258 ? 56.428 1.188 -16.716 1.00 33.26 ? 258 GLU A C 1 ATOM 2026 O O . GLU A 1 258 ? 57.077 0.211 -17.097 1.00 34.58 ? 258 GLU A O 1 ATOM 2027 C CB . GLU A 1 258 ? 54.647 2.268 -18.082 1.00 30.35 ? 258 GLU A CB 1 ATOM 2028 C CG . GLU A 1 258 ? 53.332 2.054 -18.815 1.00 36.84 ? 258 GLU A CG 1 ATOM 2029 C CD . GLU A 1 258 ? 53.250 0.899 -19.792 1.00 55.46 ? 258 GLU A CD 1 ATOM 2030 O OE1 . GLU A 1 258 ? 54.237 0.138 -19.926 1.00 56.08 ? 258 GLU A OE1 1 ATOM 2031 O OE2 . GLU A 1 258 ? 52.186 0.760 -20.435 1.00 54.36 ? 258 GLU A OE2 1 ATOM 2032 N N . ARG A 1 259 ? 56.964 2.222 -16.071 1.00 27.92 ? 259 ARG A N 1 ATOM 2033 C CA . ARG A 1 259 ? 58.393 2.380 -15.824 1.00 26.81 ? 259 ARG A CA 1 ATOM 2034 C C . ARG A 1 259 ? 58.937 1.681 -14.593 1.00 31.02 ? 259 ARG A C 1 ATOM 2035 O O . ARG A 1 259 ? 60.058 1.198 -14.627 1.00 30.89 ? 259 ARG A O 1 ATOM 2036 C CB . ARG A 1 259 ? 58.744 3.856 -15.763 1.00 23.88 ? 259 ARG A CB 1 ATOM 2037 C CG . ARG A 1 259 ? 58.127 4.692 -16.878 1.00 24.27 ? 259 ARG A CG 1 ATOM 2038 C CD . ARG A 1 259 ? 58.322 6.159 -16.606 1.00 16.79 ? 259 ARG A CD 1 ATOM 2039 N NE . ARG A 1 259 ? 59.729 6.428 -16.317 1.00 19.14 ? 259 ARG A NE 1 ATOM 2040 C CZ . ARG A 1 259 ? 60.240 7.626 -16.090 1.00 34.51 ? 259 ARG A CZ 1 ATOM 2041 N NH1 . ARG A 1 259 ? 59.466 8.700 -16.119 1.00 27.35 ? 259 ARG A NH1 1 ATOM 2042 N NH2 . ARG A 1 259 ? 61.533 7.762 -15.831 1.00 23.79 ? 259 ARG A NH2 1 ATOM 2043 N N . LEU A 1 260 ? 58.181 1.633 -13.514 1.00 29.16 ? 260 LEU A N 1 ATOM 2044 C CA . LEU A 1 260 ? 58.671 1.026 -12.285 1.00 30.10 ? 260 LEU A CA 1 ATOM 2045 C C . LEU A 1 260 ? 57.979 -0.278 -11.873 1.00 36.98 ? 260 LEU A C 1 ATOM 2046 O O . LEU A 1 260 ? 58.672 -1.276 -11.695 1.00 37.35 ? 260 LEU A O 1 ATOM 2047 C CB . LEU A 1 260 ? 58.598 2.063 -11.146 1.00 30.28 ? 260 LEU A CB 1 ATOM 2048 C CG . LEU A 1 260 ? 58.949 1.606 -9.737 1.00 35.63 ? 260 LEU A CG 1 ATOM 2049 C CD1 . LEU A 1 260 ? 60.445 1.221 -9.624 1.00 35.39 ? 260 LEU A CD1 1 ATOM 2050 C CD2 . LEU A 1 260 ? 58.560 2.676 -8.723 1.00 38.26 ? 260 LEU A CD2 1 ATOM 2051 N N . TYR A 1 261 ? 56.641 -0.267 -11.678 1.00 34.81 ? 261 TYR A N 1 ATOM 2052 C CA . TYR A 1 261 ? 55.885 -1.400 -11.140 1.00 34.58 ? 261 TYR A CA 1 ATOM 2053 C C . TYR A 1 261 ? 55.871 -2.654 -12.007 1.00 41.36 ? 261 TYR A C 1 ATOM 2054 O O . TYR A 1 261 ? 55.906 -3.740 -11.433 1.00 43.34 ? 261 TYR A O 1 ATOM 2055 C CB . TYR A 1 261 ? 54.455 -1.002 -10.756 1.00 34.48 ? 261 TYR A CB 1 ATOM 2056 C CG . TYR A 1 261 ? 54.348 0.183 -9.820 1.00 34.97 ? 261 TYR A CG 1 ATOM 2057 C CD1 . TYR A 1 261 ? 55.282 0.384 -8.802 1.00 36.67 ? 261 TYR A CD1 1 ATOM 2058 C CD2 . TYR A 1 261 ? 53.276 1.068 -9.905 1.00 35.48 ? 261 TYR A CD2 1 ATOM 2059 C CE1 . TYR A 1 261 ? 55.185 1.470 -7.935 1.00 36.36 ? 261 TYR A CE1 1 ATOM 2060 C CE2 . TYR A 1 261 ? 53.161 2.150 -9.033 1.00 36.37 ? 261 TYR A CE2 1 ATOM 2061 C CZ . TYR A 1 261 ? 54.126 2.355 -8.058 1.00 41.95 ? 261 TYR A CZ 1 ATOM 2062 O OH . TYR A 1 261 ? 54.036 3.433 -7.216 1.00 39.86 ? 261 TYR A OH 1 ATOM 2063 N N . ILE A 1 262 ? 55.806 -2.541 -13.347 1.00 37.41 ? 262 ILE A N 1 ATOM 2064 C CA . ILE A 1 262 ? 55.802 -3.727 -14.233 1.00 36.64 ? 262 ILE A CA 1 ATOM 2065 C C . ILE A 1 262 ? 57.148 -4.510 -14.126 1.00 41.09 ? 262 ILE A C 1 ATOM 2066 O O . ILE A 1 262 ? 57.168 -5.741 -14.047 1.00 41.80 ? 262 ILE A O 1 ATOM 2067 C CB . ILE A 1 262 ? 55.411 -3.334 -15.701 1.00 38.19 ? 262 ILE A CB 1 ATOM 2068 C CG1 . ILE A 1 262 ? 53.891 -3.305 -15.857 1.00 37.34 ? 262 ILE A CG1 1 ATOM 2069 C CG2 . ILE A 1 262 ? 56.061 -4.234 -16.780 1.00 37.56 ? 262 ILE A CG2 1 ATOM 2070 C CD1 . ILE A 1 262 ? 53.433 -2.302 -16.811 1.00 38.06 ? 262 ILE A CD1 1 ATOM 2071 N N . GLY A 1 263 ? 58.232 -3.759 -14.103 1.00 35.94 ? 263 GLY A N 1 ATOM 2072 C CA . GLY A 1 263 ? 59.584 -4.273 -14.048 1.00 35.51 ? 263 GLY A CA 1 ATOM 2073 C C . GLY A 1 263 ? 60.586 -3.176 -14.319 1.00 40.67 ? 263 GLY A C 1 ATOM 2074 O O . GLY A 1 263 ? 60.215 -2.009 -14.507 1.00 39.55 ? 263 GLY A O 1 ATOM 2075 N N . GLY A 1 264 ? 61.853 -3.564 -14.343 1.00 39.41 ? 264 GLY A N 1 ATOM 2076 C CA . GLY A 1 264 ? 62.960 -2.645 -14.562 1.00 39.85 ? 264 GLY A CA 1 ATOM 2077 C C . GLY A 1 264 ? 64.302 -3.256 -14.224 1.00 43.30 ? 264 GLY A C 1 ATOM 2078 O O . GLY A 1 264 ? 64.354 -4.374 -13.700 1.00 42.52 ? 264 GLY A O 1 ATOM 2079 N N . PRO A 1 265 ? 65.408 -2.545 -14.542 1.00 39.87 ? 265 PRO A N 1 ATOM 2080 C CA . PRO A 1 265 ? 66.740 -3.108 -14.280 1.00 39.54 ? 265 PRO A CA 1 ATOM 2081 C C . PRO A 1 265 ? 67.077 -3.112 -12.805 1.00 42.07 ? 265 PRO A C 1 ATOM 2082 O O . PRO A 1 265 ? 66.625 -2.231 -12.080 1.00 42.06 ? 265 PRO A O 1 ATOM 2083 C CB . PRO A 1 265 ? 67.673 -2.200 -15.081 1.00 41.38 ? 265 PRO A CB 1 ATOM 2084 C CG . PRO A 1 265 ? 66.972 -0.902 -15.121 1.00 45.85 ? 265 PRO A CG 1 ATOM 2085 C CD . PRO A 1 265 ? 65.504 -1.213 -15.179 1.00 41.51 ? 265 PRO A CD 1 ATOM 2086 N N . LEU A 1 266 ? 67.868 -4.103 -12.378 1.00 37.65 ? 266 LEU A N 1 ATOM 2087 C CA . LEU A 1 266 ? 68.275 -4.317 -10.995 1.00 37.29 ? 266 LEU A CA 1 ATOM 2088 C C . LEU A 1 266 ? 69.724 -3.937 -10.802 1.00 44.08 ? 266 LEU A C 1 ATOM 2089 O O . LEU A 1 266 ? 70.587 -4.480 -11.485 1.00 45.80 ? 266 LEU A O 1 ATOM 2090 C CB . LEU A 1 266 ? 68.044 -5.785 -10.616 1.00 36.89 ? 266 LEU A CB 1 ATOM 2091 C CG . LEU A 1 266 ? 66.606 -6.276 -10.727 1.00 40.67 ? 266 LEU A CG 1 ATOM 2092 C CD1 . LEU A 1 266 ? 66.552 -7.772 -10.943 1.00 40.17 ? 266 LEU A CD1 1 ATOM 2093 C CD2 . LEU A 1 266 ? 65.812 -5.876 -9.521 1.00 43.05 ? 266 LEU A CD2 1 ATOM 2094 N N . THR A 1 267 ? 69.993 -2.991 -9.892 1.00 41.34 ? 267 THR A N 1 ATOM 2095 C CA . THR A 1 267 ? 71.345 -2.491 -9.604 1.00 41.97 ? 267 THR A CA 1 ATOM 2096 C C . THR A 1 267 ? 71.793 -2.828 -8.171 1.00 47.57 ? 267 THR A C 1 ATOM 2097 O O . THR A 1 267 ? 71.015 -2.660 -7.239 1.00 48.55 ? 267 THR A O 1 ATOM 2098 C CB . THR A 1 267 ? 71.410 -0.986 -9.930 1.00 50.09 ? 267 THR A CB 1 ATOM 2099 O OG1 . THR A 1 267 ? 71.078 -0.807 -11.307 1.00 51.06 ? 267 THR A OG1 1 ATOM 2100 C CG2 . THR A 1 267 ? 72.769 -0.361 -9.649 1.00 48.45 ? 267 THR A CG2 1 ATOM 2101 N N . ASN A 1 268 ? 73.038 -3.295 -7.990 1.00 43.41 ? 268 ASN A N 1 ATOM 2102 C CA . ASN A 1 268 ? 73.552 -3.580 -6.651 1.00 43.17 ? 268 ASN A CA 1 ATOM 2103 C C . ASN A 1 268 ? 74.025 -2.284 -5.974 1.00 49.36 ? 268 ASN A C 1 ATOM 2104 O O . ASN A 1 268 ? 74.076 -1.238 -6.626 1.00 49.12 ? 268 ASN A O 1 ATOM 2105 C CB . ASN A 1 268 ? 74.666 -4.646 -6.680 1.00 42.50 ? 268 ASN A CB 1 ATOM 2106 C CG . ASN A 1 268 ? 75.893 -4.349 -7.518 1.00 55.18 ? 268 ASN A CG 1 ATOM 2107 O OD1 . ASN A 1 268 ? 76.299 -3.197 -7.742 1.00 41.20 ? 268 ASN A OD1 1 ATOM 2108 N ND2 . ASN A 1 268 ? 76.554 -5.411 -7.945 1.00 44.45 ? 268 ASN A ND2 1 ATOM 2109 N N . SER A 1 269 ? 74.393 -2.345 -4.678 1.00 47.05 ? 269 SER A N 1 ATOM 2110 C CA . SER A 1 269 ? 74.881 -1.167 -3.955 1.00 46.67 ? 269 SER A CA 1 ATOM 2111 C C . SER A 1 269 ? 76.153 -0.584 -4.592 1.00 49.13 ? 269 SER A C 1 ATOM 2112 O O . SER A 1 269 ? 76.337 0.632 -4.582 1.00 49.75 ? 269 SER A O 1 ATOM 2113 C CB . SER A 1 269 ? 75.113 -1.493 -2.484 1.00 50.63 ? 269 SER A CB 1 ATOM 2114 O OG . SER A 1 269 ? 76.022 -2.568 -2.317 1.00 59.59 ? 269 SER A OG 1 ATOM 2115 N N . LYS A 1 270 ? 76.991 -1.446 -5.187 1.00 43.36 ? 270 LYS A N 1 ATOM 2116 C CA . LYS A 1 270 ? 78.244 -1.076 -5.838 1.00 42.42 ? 270 LYS A CA 1 ATOM 2117 C C . LYS A 1 270 ? 78.072 -0.490 -7.288 1.00 46.52 ? 270 LYS A C 1 ATOM 2118 O O . LYS A 1 270 ? 79.068 -0.183 -7.946 1.00 45.99 ? 270 LYS A O 1 ATOM 2119 C CB . LYS A 1 270 ? 79.215 -2.262 -5.800 1.00 44.13 ? 270 LYS A CB 1 ATOM 2120 C CG . LYS A 1 270 ? 79.799 -2.501 -4.413 1.00 60.09 ? 270 LYS A CG 1 ATOM 2121 C CD . LYS A 1 270 ? 80.724 -3.713 -4.372 1.00 71.62 ? 270 LYS A CD 1 ATOM 2122 C CE . LYS A 1 270 ? 81.022 -4.165 -2.961 1.00 80.02 ? 270 LYS A CE 1 ATOM 2123 N NZ . LYS A 1 270 ? 81.902 -5.363 -2.928 1.00 90.12 ? 270 LYS A NZ 1 ATOM 2124 N N . GLY A 1 271 ? 76.825 -0.303 -7.733 1.00 42.82 ? 271 GLY A N 1 ATOM 2125 C CA . GLY A 1 271 ? 76.481 0.318 -9.010 1.00 42.65 ? 271 GLY A CA 1 ATOM 2126 C C . GLY A 1 271 ? 76.494 -0.515 -10.281 1.00 47.68 ? 271 GLY A C 1 ATOM 2127 O O . GLY A 1 271 ? 76.433 0.050 -11.376 1.00 46.82 ? 271 GLY A O 1 ATOM 2128 N N . GLN A 1 272 ? 76.560 -1.845 -10.166 1.00 46.00 ? 272 GLN A N 1 ATOM 2129 C CA . GLN A 1 272 ? 76.572 -2.752 -11.327 1.00 46.53 ? 272 GLN A CA 1 ATOM 2130 C C . GLN A 1 272 ? 75.168 -3.161 -11.738 1.00 51.02 ? 272 GLN A C 1 ATOM 2131 O O . GLN A 1 272 ? 74.240 -3.046 -10.935 1.00 51.92 ? 272 GLN A O 1 ATOM 2132 C CB . GLN A 1 272 ? 77.341 -4.037 -10.982 1.00 47.91 ? 272 GLN A CB 1 ATOM 2133 C CG . GLN A 1 272 ? 78.837 -3.921 -11.137 1.00 68.95 ? 272 GLN A CG 1 ATOM 2134 C CD . GLN A 1 272 ? 79.572 -5.005 -10.393 1.00 87.55 ? 272 GLN A CD 1 ATOM 2135 O OE1 . GLN A 1 272 ? 79.293 -5.296 -9.223 1.00 81.75 ? 272 GLN A OE1 1 ATOM 2136 N NE2 . GLN A 1 272 ? 80.615 -5.537 -11.015 1.00 83.35 ? 272 GLN A NE2 1 ATOM 2137 N N . ASN A 1 273 ? 75.017 -3.725 -12.942 1.00 45.61 ? 273 ASN A N 1 ATOM 2138 C CA . ASN A 1 273 ? 73.723 -4.261 -13.328 1.00 45.08 ? 273 ASN A CA 1 ATOM 2139 C C . ASN A 1 273 ? 73.709 -5.742 -12.946 1.00 48.01 ? 273 ASN A C 1 ATOM 2140 O O . ASN A 1 273 ? 74.590 -6.485 -13.378 1.00 47.61 ? 273 ASN A O 1 ATOM 2141 C CB . ASN A 1 273 ? 73.448 -4.076 -14.820 1.00 46.34 ? 273 ASN A CB 1 ATOM 2142 C CG . ASN A 1 273 ? 71.991 -4.267 -15.171 1.00 65.82 ? 273 ASN A CG 1 ATOM 2143 O OD1 . ASN A 1 273 ? 71.087 -3.654 -14.577 1.00 63.17 ? 273 ASN A OD1 1 ATOM 2144 N ND2 . ASN A 1 273 ? 71.733 -5.124 -16.141 1.00 52.75 ? 273 ASN A ND2 1 ATOM 2145 N N . CYS A 1 274 ? 72.746 -6.155 -12.102 1.00 43.81 ? 274 CYS A N 1 ATOM 2146 C CA . CYS A 1 274 ? 72.571 -7.537 -11.654 1.00 43.61 ? 274 CYS A CA 1 ATOM 2147 C C . CYS A 1 274 ? 71.670 -8.281 -12.612 1.00 45.64 ? 274 CYS A C 1 ATOM 2148 O O . CYS A 1 274 ? 71.780 -9.501 -12.750 1.00 45.95 ? 274 CYS A O 1 ATOM 2149 C CB . CYS A 1 274 ? 72.012 -7.586 -10.236 1.00 44.69 ? 274 CYS A CB 1 ATOM 2150 S SG . CYS A 1 274 ? 73.187 -7.080 -8.962 1.00 49.28 ? 274 CYS A SG 1 ATOM 2151 N N . GLY A 1 275 ? 70.749 -7.545 -13.217 1.00 40.29 ? 275 GLY A N 1 ATOM 2152 C CA . GLY A 1 275 ? 69.796 -8.104 -14.158 1.00 39.47 ? 275 GLY A CA 1 ATOM 2153 C C . GLY A 1 275 ? 68.569 -7.248 -14.369 1.00 40.73 ? 275 GLY A C 1 ATOM 2154 O O . GLY A 1 275 ? 68.632 -6.018 -14.256 1.00 39.98 ? 275 GLY A O 1 ATOM 2155 N N . TYR A 1 276 ? 67.451 -7.917 -14.693 1.00 35.46 ? 276 TYR A N 1 ATOM 2156 C CA . TYR A 1 276 ? 66.154 -7.312 -14.998 1.00 34.52 ? 276 TYR A CA 1 ATOM 2157 C C . TYR A 1 276 ? 65.029 -8.068 -14.304 1.00 37.10 ? 276 TYR A C 1 ATOM 2158 O O . TYR A 1 276 ? 64.972 -9.299 -14.381 1.00 36.47 ? 276 TYR A O 1 ATOM 2159 C CB . TYR A 1 276 ? 65.918 -7.298 -16.525 1.00 35.46 ? 276 TYR A CB 1 ATOM 2160 C CG . TYR A 1 276 ? 64.890 -6.287 -16.975 1.00 37.11 ? 276 TYR A CG 1 ATOM 2161 C CD1 . TYR A 1 276 ? 65.237 -4.956 -17.184 1.00 38.72 ? 276 TYR A CD1 1 ATOM 2162 C CD2 . TYR A 1 276 ? 63.564 -6.656 -17.184 1.00 38.39 ? 276 TYR A CD2 1 ATOM 2163 C CE1 . TYR A 1 276 ? 64.286 -4.014 -17.578 1.00 39.00 ? 276 TYR A CE1 1 ATOM 2164 C CE2 . TYR A 1 276 ? 62.603 -5.721 -17.571 1.00 39.21 ? 276 TYR A CE2 1 ATOM 2165 C CZ . TYR A 1 276 ? 62.966 -4.398 -17.752 1.00 45.82 ? 276 TYR A CZ 1 ATOM 2166 O OH . TYR A 1 276 ? 62.019 -3.483 -18.135 1.00 47.59 ? 276 TYR A OH 1 ATOM 2167 N N . ARG A 1 277 ? 64.148 -7.314 -13.617 1.00 32.50 ? 277 ARG A N 1 ATOM 2168 C CA . ARG A 1 277 ? 62.956 -7.765 -12.898 1.00 31.23 ? 277 ARG A CA 1 ATOM 2169 C C . ARG A 1 277 ? 61.746 -7.690 -13.850 1.00 36.21 ? 277 ARG A C 1 ATOM 2170 O O . ARG A 1 277 ? 61.639 -6.776 -14.665 1.00 36.07 ? 277 ARG A O 1 ATOM 2171 C CB . ARG A 1 277 ? 62.731 -6.839 -11.692 1.00 28.46 ? 277 ARG A CB 1 ATOM 2172 C CG . ARG A 1 277 ? 61.554 -7.227 -10.798 1.00 34.26 ? 277 ARG A CG 1 ATOM 2173 C CD . ARG A 1 277 ? 61.345 -6.279 -9.636 1.00 34.68 ? 277 ARG A CD 1 ATOM 2174 N NE . ARG A 1 277 ? 61.507 -4.896 -10.067 1.00 42.59 ? 277 ARG A NE 1 ATOM 2175 C CZ . ARG A 1 277 ? 60.518 -4.074 -10.399 1.00 58.51 ? 277 ARG A CZ 1 ATOM 2176 N NH1 . ARG A 1 277 ? 59.252 -4.465 -10.289 1.00 46.81 ? 277 ARG A NH1 1 ATOM 2177 N NH2 . ARG A 1 277 ? 60.784 -2.842 -10.810 1.00 40.03 ? 277 ARG A NH2 1 ATOM 2178 N N . ARG A 1 278 ? 60.843 -8.654 -13.757 1.00 32.99 ? 278 ARG A N 1 ATOM 2179 C CA . ARG A 1 278 ? 59.642 -8.683 -14.592 1.00 32.27 ? 278 ARG A CA 1 ATOM 2180 C C . ARG A 1 278 ? 58.453 -9.092 -13.735 1.00 34.50 ? 278 ARG A C 1 ATOM 2181 O O . ARG A 1 278 ? 57.476 -9.635 -14.237 1.00 33.41 ? 278 ARG A O 1 ATOM 2182 C CB . ARG A 1 278 ? 59.834 -9.635 -15.785 1.00 33.65 ? 278 ARG A CB 1 ATOM 2183 C CG . ARG A 1 278 ? 60.705 -9.058 -16.889 1.00 45.49 ? 278 ARG A CG 1 ATOM 2184 C CD . ARG A 1 278 ? 60.631 -9.858 -18.165 1.00 53.98 ? 278 ARG A CD 1 ATOM 2185 N NE . ARG A 1 278 ? 61.841 -9.667 -18.960 1.00 62.99 ? 278 ARG A NE 1 ATOM 2186 C CZ . ARG A 1 278 ? 62.907 -10.459 -18.897 1.00 78.97 ? 278 ARG A CZ 1 ATOM 2187 N NH1 . ARG A 1 278 ? 62.912 -11.515 -18.088 1.00 63.47 ? 278 ARG A NH1 1 ATOM 2188 N NH2 . ARG A 1 278 ? 63.976 -10.202 -19.640 1.00 67.53 ? 278 ARG A NH2 1 ATOM 2189 N N . CYS A 1 279 ? 58.551 -8.813 -12.424 1.00 30.96 ? 279 CYS A N 1 ATOM 2190 C CA . CYS A 1 279 ? 57.562 -9.144 -11.408 1.00 30.62 ? 279 CYS A CA 1 ATOM 2191 C C . CYS A 1 279 ? 57.506 -8.013 -10.385 1.00 36.96 ? 279 CYS A C 1 ATOM 2192 O O . CYS A 1 279 ? 58.095 -6.953 -10.629 1.00 38.22 ? 279 CYS A O 1 ATOM 2193 C CB . CYS A 1 279 ? 57.903 -10.481 -10.752 1.00 30.41 ? 279 CYS A CB 1 ATOM 2194 S SG . CYS A 1 279 ? 59.491 -10.496 -9.880 1.00 33.75 ? 279 CYS A SG 1 ATOM 2195 N N . ARG A 1 280 ? 56.802 -8.241 -9.247 1.00 32.21 ? 280 ARG A N 1 ATOM 2196 C CA . ARG A 1 280 ? 56.628 -7.284 -8.163 1.00 31.64 ? 280 ARG A CA 1 ATOM 2197 C C . ARG A 1 280 ? 57.952 -6.871 -7.487 1.00 37.98 ? 280 ARG A C 1 ATOM 2198 O O . ARG A 1 280 ? 58.761 -7.741 -7.126 1.00 38.87 ? 280 ARG A O 1 ATOM 2199 C CB . ARG A 1 280 ? 55.661 -7.857 -7.108 1.00 28.66 ? 280 ARG A CB 1 ATOM 2200 C CG . ARG A 1 280 ? 55.605 -7.074 -5.779 1.00 29.89 ? 280 ARG A CG 1 ATOM 2201 C CD . ARG A 1 280 ? 54.562 -5.973 -5.764 1.00 39.42 ? 280 ARG A CD 1 ATOM 2202 N NE . ARG A 1 280 ? 53.232 -6.559 -5.899 1.00 49.30 ? 280 ARG A NE 1 ATOM 2203 C CZ . ARG A 1 280 ? 52.296 -6.152 -6.746 1.00 52.00 ? 280 ARG A CZ 1 ATOM 2204 N NH1 . ARG A 1 280 ? 52.502 -5.088 -7.515 1.00 29.97 ? 280 ARG A NH1 1 ATOM 2205 N NH2 . ARG A 1 280 ? 51.140 -6.793 -6.820 1.00 29.89 ? 280 ARG A NH2 1 ATOM 2206 N N . ALA A 1 281 ? 58.140 -5.538 -7.277 1.00 32.82 ? 281 ALA A N 1 ATOM 2207 C CA . ALA A 1 281 ? 59.274 -4.987 -6.543 1.00 30.85 ? 281 ALA A CA 1 ATOM 2208 C C . ALA A 1 281 ? 58.864 -5.054 -5.082 1.00 37.43 ? 281 ALA A C 1 ATOM 2209 O O . ALA A 1 281 ? 57.776 -4.601 -4.741 1.00 39.16 ? 281 ALA A O 1 ATOM 2210 C CB . ALA A 1 281 ? 59.517 -3.545 -6.948 1.00 30.46 ? 281 ALA A CB 1 ATOM 2211 N N . SER A 1 282 ? 59.690 -5.655 -4.227 1.00 34.26 ? 282 SER A N 1 ATOM 2212 C CA . SER A 1 282 ? 59.407 -5.793 -2.791 1.00 33.96 ? 282 SER A CA 1 ATOM 2213 C C . SER A 1 282 ? 59.389 -4.454 -2.003 1.00 37.03 ? 282 SER A C 1 ATOM 2214 O O . SER A 1 282 ? 58.689 -4.343 -0.992 1.00 37.14 ? 282 SER A O 1 ATOM 2215 C CB . SER A 1 282 ? 60.372 -6.786 -2.150 1.00 37.74 ? 282 SER A CB 1 ATOM 2216 O OG . SER A 1 282 ? 61.630 -6.831 -2.807 1.00 47.00 ? 282 SER A OG 1 ATOM 2217 N N . GLY A 1 283 ? 60.123 -3.457 -2.493 1.00 31.86 ? 283 GLY A N 1 ATOM 2218 C CA . GLY A 1 283 ? 60.225 -2.148 -1.860 1.00 31.21 ? 283 GLY A CA 1 ATOM 2219 C C . GLY A 1 283 ? 59.576 -0.977 -2.570 1.00 33.82 ? 283 GLY A C 1 ATOM 2220 O O . GLY A 1 283 ? 60.192 0.091 -2.645 1.00 33.83 ? 283 GLY A O 1 ATOM 2221 N N . VAL A 1 284 ? 58.311 -1.149 -3.059 1.00 28.37 ? 284 VAL A N 1 ATOM 2222 C CA . VAL A 1 284 ? 57.507 -0.078 -3.680 1.00 27.13 ? 284 VAL A CA 1 ATOM 2223 C C . VAL A 1 284 ? 56.263 0.202 -2.833 1.00 31.96 ? 284 VAL A C 1 ATOM 2224 O O . VAL A 1 284 ? 55.821 -0.683 -2.089 1.00 31.79 ? 284 VAL A O 1 ATOM 2225 C CB . VAL A 1 284 ? 57.175 -0.236 -5.192 1.00 30.46 ? 284 VAL A CB 1 ATOM 2226 C CG1 . VAL A 1 284 ? 58.425 -0.107 -6.061 1.00 29.94 ? 284 VAL A CG1 1 ATOM 2227 C CG2 . VAL A 1 284 ? 56.412 -1.525 -5.497 1.00 30.24 ? 284 VAL A CG2 1 ATOM 2228 N N . LEU A 1 285 ? 55.713 1.443 -2.922 1.00 29.28 ? 285 LEU A N 1 ATOM 2229 C CA . LEU A 1 285 ? 54.523 1.875 -2.170 1.00 28.99 ? 285 LEU A CA 1 ATOM 2230 C C . LEU A 1 285 ? 53.319 0.954 -2.346 1.00 32.09 ? 285 LEU A C 1 ATOM 2231 O O . LEU A 1 285 ? 52.639 0.643 -1.358 1.00 32.64 ? 285 LEU A O 1 ATOM 2232 C CB . LEU A 1 285 ? 54.139 3.336 -2.473 1.00 28.99 ? 285 LEU A CB 1 ATOM 2233 C CG . LEU A 1 285 ? 52.991 3.928 -1.609 1.00 32.95 ? 285 LEU A CG 1 ATOM 2234 C CD1 . LEU A 1 285 ? 53.412 4.163 -0.183 1.00 31.92 ? 285 LEU A CD1 1 ATOM 2235 C CD2 . LEU A 1 285 ? 52.476 5.198 -2.185 1.00 35.65 ? 285 LEU A CD2 1 ATOM 2236 N N . THR A 1 286 ? 53.084 0.501 -3.595 1.00 26.11 ? 286 THR A N 1 ATOM 2237 C CA . THR A 1 286 ? 51.989 -0.383 -3.989 1.00 24.64 ? 286 THR A CA 1 ATOM 2238 C C . THR A 1 286 ? 52.243 -1.886 -3.760 1.00 31.14 ? 286 THR A C 1 ATOM 2239 O O . THR A 1 286 ? 51.413 -2.680 -4.198 1.00 31.49 ? 286 THR A O 1 ATOM 2240 C CB . THR A 1 286 ? 51.611 -0.123 -5.445 1.00 24.78 ? 286 THR A CB 1 ATOM 2241 O OG1 . THR A 1 286 ? 52.755 -0.328 -6.254 1.00 23.37 ? 286 THR A OG1 1 ATOM 2242 C CG2 . THR A 1 286 ? 51.041 1.247 -5.672 1.00 19.59 ? 286 THR A CG2 1 ATOM 2243 N N . THR A 1 287 ? 53.345 -2.298 -3.065 1.00 29.51 ? 287 THR A N 1 ATOM 2244 C CA . THR A 1 287 ? 53.632 -3.727 -2.805 1.00 29.52 ? 287 THR A CA 1 ATOM 2245 C C . THR A 1 287 ? 52.530 -4.386 -1.972 1.00 32.09 ? 287 THR A C 1 ATOM 2246 O O . THR A 1 287 ? 52.019 -5.425 -2.369 1.00 32.44 ? 287 THR A O 1 ATOM 2247 C CB . THR A 1 287 ? 55.034 -3.934 -2.196 1.00 44.20 ? 287 THR A CB 1 ATOM 2248 O OG1 . THR A 1 287 ? 56.007 -3.441 -3.111 1.00 47.02 ? 287 THR A OG1 1 ATOM 2249 C CG2 . THR A 1 287 ? 55.346 -5.413 -1.868 1.00 43.42 ? 287 THR A CG2 1 ATOM 2250 N N . SER A 1 288 ? 52.161 -3.779 -0.841 1.00 27.28 ? 288 SER A N 1 ATOM 2251 C CA . SER A 1 288 ? 51.125 -4.297 0.036 1.00 26.56 ? 288 SER A CA 1 ATOM 2252 C C . SER A 1 288 ? 49.782 -4.317 -0.655 1.00 32.12 ? 288 SER A C 1 ATOM 2253 O O . SER A 1 288 ? 49.222 -5.395 -0.811 1.00 32.04 ? 288 SER A O 1 ATOM 2254 C CB . SER A 1 288 ? 51.056 -3.492 1.322 1.00 29.85 ? 288 SER A CB 1 ATOM 2255 O OG . SER A 1 288 ? 50.753 -4.353 2.406 1.00 46.09 ? 288 SER A OG 1 ATOM 2256 N N . CYS A 1 289 ? 49.304 -3.144 -1.129 1.00 30.19 ? 289 CYS A N 1 ATOM 2257 C CA . CYS A 1 289 ? 48.028 -2.926 -1.813 1.00 30.30 ? 289 CYS A CA 1 ATOM 2258 C C . CYS A 1 289 ? 47.886 -3.805 -3.063 1.00 30.62 ? 289 CYS A C 1 ATOM 2259 O O . CYS A 1 289 ? 46.918 -4.560 -3.166 1.00 29.98 ? 289 CYS A O 1 ATOM 2260 C CB . CYS A 1 289 ? 47.853 -1.443 -2.126 1.00 32.28 ? 289 CYS A CB 1 ATOM 2261 S SG . CYS A 1 289 ? 46.303 -1.009 -2.966 1.00 37.47 ? 289 CYS A SG 1 ATOM 2262 N N . GLY A 1 290 ? 48.870 -3.740 -3.956 1.00 25.17 ? 290 GLY A N 1 ATOM 2263 C CA . GLY A 1 290 ? 48.922 -4.551 -5.163 1.00 24.83 ? 290 GLY A CA 1 ATOM 2264 C C . GLY A 1 290 ? 48.790 -6.031 -4.860 1.00 27.88 ? 290 GLY A C 1 ATOM 2265 O O . GLY A 1 290 ? 47.939 -6.712 -5.440 1.00 27.76 ? 290 GLY A O 1 ATOM 2266 N N . ASN A 1 291 ? 49.609 -6.528 -3.925 1.00 24.59 ? 291 ASN A N 1 ATOM 2267 C CA . ASN A 1 291 ? 49.584 -7.925 -3.499 1.00 24.80 ? 291 ASN A CA 1 ATOM 2268 C C . ASN A 1 291 ? 48.226 -8.328 -2.943 1.00 29.84 ? 291 ASN A C 1 ATOM 2269 O O . ASN A 1 291 ? 47.781 -9.418 -3.271 1.00 29.40 ? 291 ASN A O 1 ATOM 2270 C CB . ASN A 1 291 ? 50.697 -8.242 -2.485 1.00 25.00 ? 291 ASN A CB 1 ATOM 2271 C CG . ASN A 1 291 ? 52.071 -8.501 -3.088 1.00 45.64 ? 291 ASN A CG 1 ATOM 2272 O OD1 . ASN A 1 291 ? 52.258 -8.603 -4.307 1.00 34.50 ? 291 ASN A OD1 1 ATOM 2273 N ND2 . ASN A 1 291 ? 53.069 -8.669 -2.239 1.00 37.18 ? 291 ASN A ND2 1 ATOM 2274 N N . THR A 1 292 ? 47.559 -7.453 -2.135 1.00 26.87 ? 292 THR A N 1 ATOM 2275 C CA . THR A 1 292 ? 46.247 -7.714 -1.526 1.00 27.20 ? 292 THR A CA 1 ATOM 2276 C C . THR A 1 292 ? 45.185 -7.801 -2.613 1.00 32.97 ? 292 THR A C 1 ATOM 2277 O O . THR A 1 292 ? 44.348 -8.706 -2.590 1.00 34.28 ? 292 THR A O 1 ATOM 2278 C CB . THR A 1 292 ? 45.864 -6.649 -0.475 1.00 42.04 ? 292 THR A CB 1 ATOM 2279 O OG1 . THR A 1 292 ? 46.982 -6.279 0.323 1.00 47.69 ? 292 THR A OG1 1 ATOM 2280 C CG2 . THR A 1 292 ? 44.795 -7.131 0.460 1.00 42.19 ? 292 THR A CG2 1 ATOM 2281 N N . LEU A 1 293 ? 45.218 -6.868 -3.571 1.00 28.85 ? 293 LEU A N 1 ATOM 2282 C CA . LEU A 1 293 ? 44.267 -6.875 -4.677 1.00 28.45 ? 293 LEU A CA 1 ATOM 2283 C C . LEU A 1 293 ? 44.454 -8.129 -5.535 1.00 34.01 ? 293 LEU A C 1 ATOM 2284 O O . LEU A 1 293 ? 43.488 -8.859 -5.742 1.00 34.55 ? 293 LEU A O 1 ATOM 2285 C CB . LEU A 1 293 ? 44.382 -5.601 -5.542 1.00 27.78 ? 293 LEU A CB 1 ATOM 2286 C CG . LEU A 1 293 ? 44.088 -4.249 -4.888 1.00 30.78 ? 293 LEU A CG 1 ATOM 2287 C CD1 . LEU A 1 293 ? 44.523 -3.133 -5.809 1.00 30.24 ? 293 LEU A CD1 1 ATOM 2288 C CD2 . LEU A 1 293 ? 42.605 -4.107 -4.539 1.00 31.90 ? 293 LEU A CD2 1 ATOM 2289 N N . THR A 1 294 ? 45.693 -8.404 -5.987 1.00 30.29 ? 294 THR A N 1 ATOM 2290 C CA . THR A 1 294 ? 45.993 -9.556 -6.833 1.00 30.76 ? 294 THR A CA 1 ATOM 2291 C C . THR A 1 294 ? 45.710 -10.902 -6.090 1.00 36.88 ? 294 THR A C 1 ATOM 2292 O O . THR A 1 294 ? 45.227 -11.840 -6.725 1.00 36.49 ? 294 THR A O 1 ATOM 2293 C CB . THR A 1 294 ? 47.405 -9.407 -7.428 1.00 37.10 ? 294 THR A CB 1 ATOM 2294 O OG1 . THR A 1 294 ? 47.427 -8.214 -8.210 1.00 33.78 ? 294 THR A OG1 1 ATOM 2295 C CG2 . THR A 1 294 ? 47.809 -10.563 -8.331 1.00 33.41 ? 294 THR A CG2 1 ATOM 2296 N N . CYS A 1 295 ? 45.937 -10.981 -4.765 1.00 34.94 ? 295 CYS A N 1 ATOM 2297 C CA . CYS A 1 295 ? 45.640 -12.214 -4.023 1.00 35.00 ? 295 CYS A CA 1 ATOM 2298 C C . CYS A 1 295 ? 44.138 -12.426 -3.923 1.00 37.46 ? 295 CYS A C 1 ATOM 2299 O O . CYS A 1 295 ? 43.669 -13.512 -4.260 1.00 36.50 ? 295 CYS A O 1 ATOM 2300 C CB . CYS A 1 295 ? 46.312 -12.249 -2.651 1.00 35.58 ? 295 CYS A CB 1 ATOM 2301 S SG . CYS A 1 295 ? 46.011 -13.774 -1.716 1.00 39.56 ? 295 CYS A SG 1 ATOM 2302 N N . TYR A 1 296 ? 43.387 -11.389 -3.501 1.00 33.88 ? 296 TYR A N 1 ATOM 2303 C CA . TYR A 1 296 ? 41.922 -11.415 -3.415 1.00 34.30 ? 296 TYR A CA 1 ATOM 2304 C C . TYR A 1 296 ? 41.279 -11.694 -4.783 1.00 38.27 ? 296 TYR A C 1 ATOM 2305 O O . TYR A 1 296 ? 40.345 -12.480 -4.844 1.00 38.56 ? 296 TYR A O 1 ATOM 2306 C CB . TYR A 1 296 ? 41.405 -10.100 -2.844 1.00 35.93 ? 296 TYR A CB 1 ATOM 2307 C CG . TYR A 1 296 ? 39.906 -9.902 -2.905 1.00 38.01 ? 296 TYR A CG 1 ATOM 2308 C CD1 . TYR A 1 296 ? 39.092 -10.255 -1.829 1.00 39.15 ? 296 TYR A CD1 1 ATOM 2309 C CD2 . TYR A 1 296 ? 39.318 -9.218 -3.967 1.00 39.29 ? 296 TYR A CD2 1 ATOM 2310 C CE1 . TYR A 1 296 ? 37.726 -9.987 -1.838 1.00 38.55 ? 296 TYR A CE1 1 ATOM 2311 C CE2 . TYR A 1 296 ? 37.954 -8.941 -3.985 1.00 40.12 ? 296 TYR A CE2 1 ATOM 2312 C CZ . TYR A 1 296 ? 37.161 -9.333 -2.920 1.00 46.14 ? 296 TYR A CZ 1 ATOM 2313 O OH . TYR A 1 296 ? 35.815 -9.075 -2.945 1.00 47.33 ? 296 TYR A OH 1 ATOM 2314 N N . LEU A 1 297 ? 41.774 -11.059 -5.867 1.00 34.27 ? 297 LEU A N 1 ATOM 2315 C CA . LEU A 1 297 ? 41.273 -11.284 -7.224 1.00 33.83 ? 297 LEU A CA 1 ATOM 2316 C C . LEU A 1 297 ? 41.444 -12.764 -7.652 1.00 39.25 ? 297 LEU A C 1 ATOM 2317 O O . LEU A 1 297 ? 40.504 -13.357 -8.177 1.00 39.74 ? 297 LEU A O 1 ATOM 2318 C CB . LEU A 1 297 ? 41.928 -10.313 -8.243 1.00 33.16 ? 297 LEU A CB 1 ATOM 2319 C CG . LEU A 1 297 ? 41.684 -10.539 -9.757 1.00 37.07 ? 297 LEU A CG 1 ATOM 2320 C CD1 . LEU A 1 297 ? 40.193 -10.613 -10.111 1.00 36.55 ? 297 LEU A CD1 1 ATOM 2321 C CD2 . LEU A 1 297 ? 42.338 -9.454 -10.579 1.00 38.65 ? 297 LEU A CD2 1 ATOM 2322 N N . LYS A 1 298 ? 42.616 -13.357 -7.401 1.00 35.11 ? 298 LYS A N 1 ATOM 2323 C CA . LYS A 1 298 ? 42.869 -14.748 -7.771 1.00 34.53 ? 298 LYS A CA 1 ATOM 2324 C C . LYS A 1 298 ? 42.108 -15.739 -6.885 1.00 40.00 ? 298 LYS A C 1 ATOM 2325 O O . LYS A 1 298 ? 41.570 -16.715 -7.400 1.00 40.00 ? 298 LYS A O 1 ATOM 2326 C CB . LYS A 1 298 ? 44.377 -15.046 -7.793 1.00 35.50 ? 298 LYS A CB 1 ATOM 2327 C CG . LYS A 1 298 ? 45.119 -14.274 -8.869 1.00 29.38 ? 298 LYS A CG 1 ATOM 2328 C CD . LYS A 1 298 ? 46.605 -14.530 -8.872 1.00 28.97 ? 298 LYS A CD 1 ATOM 2329 C CE . LYS A 1 298 ? 47.254 -13.731 -9.971 1.00 41.20 ? 298 LYS A CE 1 ATOM 2330 N NZ . LYS A 1 298 ? 48.707 -14.004 -10.068 1.00 42.52 ? 298 LYS A NZ 1 ATOM 2331 N N . ALA A 1 299 ? 42.048 -15.479 -5.564 1.00 37.03 ? 299 ALA A N 1 ATOM 2332 C CA . ALA A 1 299 ? 41.388 -16.354 -4.593 1.00 36.41 ? 299 ALA A CA 1 ATOM 2333 C C . ALA A 1 299 ? 39.870 -16.348 -4.672 1.00 38.82 ? 299 ALA A C 1 ATOM 2334 O O . ALA A 1 299 ? 39.278 -17.404 -4.498 1.00 38.39 ? 299 ALA A O 1 ATOM 2335 C CB . ALA A 1 299 ? 41.852 -16.034 -3.192 1.00 37.06 ? 299 ALA A CB 1 ATOM 2336 N N . SER A 1 300 ? 39.239 -15.177 -4.919 1.00 35.29 ? 300 SER A N 1 ATOM 2337 C CA . SER A 1 300 ? 37.788 -15.046 -5.083 1.00 35.24 ? 300 SER A CA 1 ATOM 2338 C C . SER A 1 300 ? 37.362 -15.833 -6.332 1.00 40.81 ? 300 SER A C 1 ATOM 2339 O O . SER A 1 300 ? 36.371 -16.558 -6.286 1.00 40.79 ? 300 SER A O 1 ATOM 2340 C CB . SER A 1 300 ? 37.393 -13.583 -5.257 1.00 39.15 ? 300 SER A CB 1 ATOM 2341 O OG . SER A 1 300 ? 37.769 -12.778 -4.153 1.00 50.49 ? 300 SER A OG 1 ATOM 2342 N N . ALA A 1 301 ? 38.127 -15.690 -7.439 1.00 37.93 ? 301 ALA A N 1 ATOM 2343 C CA . ALA A 1 301 ? 37.927 -16.376 -8.709 1.00 38.05 ? 301 ALA A CA 1 ATOM 2344 C C . ALA A 1 301 ? 38.125 -17.894 -8.543 1.00 43.99 ? 301 ALA A C 1 ATOM 2345 O O . ALA A 1 301 ? 37.344 -18.678 -9.099 1.00 43.71 ? 301 ALA A O 1 ATOM 2346 C CB . ALA A 1 301 ? 38.895 -15.831 -9.741 1.00 38.76 ? 301 ALA A CB 1 ATOM 2347 N N . ALA A 1 302 ? 39.156 -18.300 -7.756 1.00 41.76 ? 302 ALA A N 1 ATOM 2348 C CA . ALA A 1 302 ? 39.479 -19.696 -7.428 1.00 41.95 ? 302 ALA A CA 1 ATOM 2349 C C . ALA A 1 302 ? 38.445 -20.309 -6.462 1.00 49.31 ? 302 ALA A C 1 ATOM 2350 O O . ALA A 1 302 ? 38.270 -21.530 -6.465 1.00 49.70 ? 302 ALA A O 1 ATOM 2351 C CB . ALA A 1 302 ? 40.873 -19.790 -6.839 1.00 42.26 ? 302 ALA A CB 1 ATOM 2352 N N . CYS A 1 303 ? 37.756 -19.467 -5.649 1.00 47.62 ? 303 CYS A N 1 ATOM 2353 C CA . CYS A 1 303 ? 36.706 -19.908 -4.725 1.00 48.68 ? 303 CYS A CA 1 ATOM 2354 C C . CYS A 1 303 ? 35.523 -20.365 -5.565 1.00 50.39 ? 303 CYS A C 1 ATOM 2355 O O . CYS A 1 303 ? 34.943 -21.412 -5.283 1.00 50.22 ? 303 CYS A O 1 ATOM 2356 C CB . CYS A 1 303 ? 36.304 -18.790 -3.763 1.00 50.58 ? 303 CYS A CB 1 ATOM 2357 S SG . CYS A 1 303 ? 36.822 -19.051 -2.039 1.00 55.68 ? 303 CYS A SG 1 ATOM 2358 N N . ARG A 1 304 ? 35.190 -19.580 -6.615 1.00 45.64 ? 304 ARG A N 1 ATOM 2359 C CA . ARG A 1 304 ? 34.106 -19.816 -7.576 1.00 44.43 ? 304 ARG A CA 1 ATOM 2360 C C . ARG A 1 304 ? 34.420 -21.016 -8.440 1.00 48.91 ? 304 ARG A C 1 ATOM 2361 O O . ARG A 1 304 ? 33.528 -21.817 -8.693 1.00 49.40 ? 304 ARG A O 1 ATOM 2362 C CB . ARG A 1 304 ? 33.868 -18.586 -8.451 1.00 40.95 ? 304 ARG A CB 1 ATOM 2363 C CG . ARG A 1 304 ? 33.552 -17.342 -7.643 1.00 44.70 ? 304 ARG A CG 1 ATOM 2364 C CD . ARG A 1 304 ? 33.189 -16.155 -8.517 1.00 44.44 ? 304 ARG A CD 1 ATOM 2365 N NE . ARG A 1 304 ? 32.840 -14.991 -7.702 1.00 44.80 ? 304 ARG A NE 1 ATOM 2366 C CZ . ARG A 1 304 ? 32.239 -13.899 -8.163 1.00 52.63 ? 304 ARG A CZ 1 ATOM 2367 N NH1 . ARG A 1 304 ? 31.906 -13.807 -9.447 1.00 41.46 ? 304 ARG A NH1 1 ATOM 2368 N NH2 . ARG A 1 304 ? 31.954 -12.894 -7.341 1.00 23.90 ? 304 ARG A NH2 1 ATOM 2369 N N . ALA A 1 305 ? 35.687 -21.163 -8.866 1.00 45.12 ? 305 ALA A N 1 ATOM 2370 C CA . ALA A 1 305 ? 36.162 -22.306 -9.646 1.00 45.15 ? 305 ALA A CA 1 ATOM 2371 C C . ALA A 1 305 ? 35.999 -23.620 -8.848 1.00 48.62 ? 305 ALA A C 1 ATOM 2372 O O . ALA A 1 305 ? 35.657 -24.642 -9.434 1.00 48.26 ? 305 ALA A O 1 ATOM 2373 C CB . ALA A 1 305 ? 37.622 -22.104 -10.020 1.00 46.09 ? 305 ALA A CB 1 ATOM 2374 N N . ALA A 1 306 ? 36.203 -23.565 -7.507 1.00 45.31 ? 306 ALA A N 1 ATOM 2375 C CA . ALA A 1 306 ? 36.078 -24.680 -6.554 1.00 45.21 ? 306 ALA A CA 1 ATOM 2376 C C . ALA A 1 306 ? 34.641 -24.943 -6.058 1.00 49.27 ? 306 ALA A C 1 ATOM 2377 O O . ALA A 1 306 ? 34.410 -25.945 -5.367 1.00 49.18 ? 306 ALA A O 1 ATOM 2378 C CB . ALA A 1 306 ? 36.995 -24.443 -5.362 1.00 45.98 ? 306 ALA A CB 1 ATOM 2379 N N . LYS A 1 307 ? 33.679 -24.061 -6.421 1.00 45.25 ? 307 LYS A N 1 ATOM 2380 C CA . LYS A 1 307 ? 32.262 -24.111 -6.003 1.00 44.45 ? 307 LYS A CA 1 ATOM 2381 C C . LYS A 1 307 ? 32.146 -24.163 -4.450 1.00 48.16 ? 307 LYS A C 1 ATOM 2382 O O . LYS A 1 307 ? 31.336 -24.894 -3.877 1.00 47.89 ? 307 LYS A O 1 ATOM 2383 C CB . LYS A 1 307 ? 31.471 -25.223 -6.719 1.00 45.48 ? 307 LYS A CB 1 ATOM 2384 C CG . LYS A 1 307 ? 31.357 -25.030 -8.220 1.00 56.64 ? 307 LYS A CG 1 ATOM 2385 C CD . LYS A 1 307 ? 30.210 -25.851 -8.793 1.00 64.90 ? 307 LYS A CD 1 ATOM 2386 C CE . LYS A 1 307 ? 30.397 -26.007 -10.266 1.00 67.08 ? 307 LYS A CE 1 ATOM 2387 N NZ . LYS A 1 307 ? 29.205 -26.632 -10.884 1.00 69.51 ? 307 LYS A NZ 1 ATOM 2388 N N . LEU A 1 308 ? 32.988 -23.368 -3.797 1.00 44.31 ? 308 LEU A N 1 ATOM 2389 C CA . LEU A 1 308 ? 33.122 -23.261 -2.354 1.00 44.64 ? 308 LEU A CA 1 ATOM 2390 C C . LEU A 1 308 ? 31.974 -22.455 -1.734 1.00 50.10 ? 308 LEU A C 1 ATOM 2391 O O . LEU A 1 308 ? 31.884 -21.233 -1.914 1.00 50.38 ? 308 LEU A O 1 ATOM 2392 C CB . LEU A 1 308 ? 34.490 -22.627 -2.063 1.00 44.67 ? 308 LEU A CB 1 ATOM 2393 C CG . LEU A 1 308 ? 35.492 -23.392 -1.216 1.00 48.96 ? 308 LEU A CG 1 ATOM 2394 C CD1 . LEU A 1 308 ? 35.644 -24.800 -1.664 1.00 48.60 ? 308 LEU A CD1 1 ATOM 2395 C CD2 . LEU A 1 308 ? 36.838 -22.728 -1.268 1.00 51.83 ? 308 LEU A CD2 1 ATOM 2396 N N . GLN A 1 309 ? 31.097 -23.160 -0.996 1.00 46.69 ? 309 GLN A N 1 ATOM 2397 C CA . GLN A 1 309 ? 29.906 -22.593 -0.373 1.00 46.50 ? 309 GLN A CA 1 ATOM 2398 C C . GLN A 1 309 ? 30.216 -21.624 0.734 1.00 53.01 ? 309 GLN A C 1 ATOM 2399 O O . GLN A 1 309 ? 30.868 -21.997 1.708 1.00 52.91 ? 309 GLN A O 1 ATOM 2400 C CB . GLN A 1 309 ? 28.935 -23.691 0.094 1.00 47.42 ? 309 GLN A CB 1 ATOM 2401 C CG . GLN A 1 309 ? 28.253 -24.444 -1.061 1.00 53.55 ? 309 GLN A CG 1 ATOM 2402 C CD . GLN A 1 309 ? 27.576 -23.523 -2.058 1.00 68.51 ? 309 GLN A CD 1 ATOM 2403 O OE1 . GLN A 1 309 ? 26.678 -22.748 -1.712 1.00 65.28 ? 309 GLN A OE1 1 ATOM 2404 N NE2 . GLN A 1 309 ? 28.020 -23.563 -3.314 1.00 56.92 ? 309 GLN A NE2 1 ATOM 2405 N N . ASP A 1 310 ? 29.743 -20.364 0.565 1.00 51.29 ? 310 ASP A N 1 ATOM 2406 C CA . ASP A 1 310 ? 29.881 -19.214 1.472 1.00 52.18 ? 310 ASP A CA 1 ATOM 2407 C C . ASP A 1 310 ? 31.328 -18.837 1.797 1.00 56.82 ? 310 ASP A C 1 ATOM 2408 O O . ASP A 1 310 ? 31.688 -18.770 2.975 1.00 57.61 ? 310 ASP A O 1 ATOM 2409 C CB . ASP A 1 310 ? 29.069 -19.410 2.761 1.00 54.94 ? 310 ASP A CB 1 ATOM 2410 C CG . ASP A 1 310 ? 27.591 -19.209 2.571 1.00 72.18 ? 310 ASP A CG 1 ATOM 2411 O OD1 . ASP A 1 310 ? 26.964 -20.034 1.861 1.00 73.56 ? 310 ASP A OD1 1 ATOM 2412 O OD2 . ASP A 1 310 ? 27.049 -18.248 3.153 1.00 80.25 ? 310 ASP A OD2 1 ATOM 2413 N N . CYS A 1 311 ? 32.146 -18.562 0.757 1.00 52.34 ? 311 CYS A N 1 ATOM 2414 C CA . CYS A 1 311 ? 33.538 -18.150 0.907 1.00 51.42 ? 311 CYS A CA 1 ATOM 2415 C C . CYS A 1 311 ? 33.614 -16.804 1.638 1.00 53.22 ? 311 CYS A C 1 ATOM 2416 O O . CYS A 1 311 ? 33.097 -15.798 1.137 1.00 52.64 ? 311 CYS A O 1 ATOM 2417 C CB . CYS A 1 311 ? 34.229 -18.069 -0.453 1.00 51.93 ? 311 CYS A CB 1 ATOM 2418 S SG . CYS A 1 311 ? 35.123 -19.569 -0.942 1.00 56.12 ? 311 CYS A SG 1 ATOM 2419 N N . THR A 1 312 ? 34.228 -16.795 2.833 1.00 48.14 ? 312 THR A N 1 ATOM 2420 C CA . THR A 1 312 ? 34.506 -15.566 3.567 1.00 47.36 ? 312 THR A CA 1 ATOM 2421 C C . THR A 1 312 ? 36.009 -15.435 3.604 1.00 50.56 ? 312 THR A C 1 ATOM 2422 O O . THR A 1 312 ? 36.679 -16.268 4.219 1.00 51.34 ? 312 THR A O 1 ATOM 2423 C CB . THR A 1 312 ? 33.878 -15.501 4.959 1.00 51.74 ? 312 THR A CB 1 ATOM 2424 O OG1 . THR A 1 312 ? 32.477 -15.791 4.882 1.00 53.33 ? 312 THR A OG1 1 ATOM 2425 C CG2 . THR A 1 312 ? 34.072 -14.130 5.594 1.00 46.98 ? 312 THR A CG2 1 ATOM 2426 N N . MET A 1 313 ? 36.537 -14.421 2.921 1.00 45.74 ? 313 MET A N 1 ATOM 2427 C CA . MET A 1 313 ? 37.979 -14.193 2.825 1.00 45.61 ? 313 MET A CA 1 ATOM 2428 C C . MET A 1 313 ? 38.491 -13.198 3.864 1.00 47.27 ? 313 MET A C 1 ATOM 2429 O O . MET A 1 313 ? 37.721 -12.408 4.415 1.00 45.61 ? 313 MET A O 1 ATOM 2430 C CB . MET A 1 313 ? 38.375 -13.689 1.414 1.00 48.38 ? 313 MET A CB 1 ATOM 2431 C CG . MET A 1 313 ? 37.543 -14.270 0.276 1.00 52.94 ? 313 MET A CG 1 ATOM 2432 S SD . MET A 1 313 ? 38.521 -15.143 -0.968 1.00 57.81 ? 313 MET A SD 1 ATOM 2433 C CE . MET A 1 313 ? 39.553 -13.817 -1.538 1.00 54.66 ? 313 MET A CE 1 ATOM 2434 N N . LEU A 1 314 ? 39.817 -13.234 4.091 1.00 42.92 ? 314 LEU A N 1 ATOM 2435 C CA . LEU A 1 314 ? 40.583 -12.327 4.924 1.00 41.79 ? 314 LEU A CA 1 ATOM 2436 C C . LEU A 1 314 ? 41.966 -12.289 4.307 1.00 44.46 ? 314 LEU A C 1 ATOM 2437 O O . LEU A 1 314 ? 42.764 -13.212 4.514 1.00 44.21 ? 314 LEU A O 1 ATOM 2438 C CB . LEU A 1 314 ? 40.598 -12.752 6.398 1.00 41.76 ? 314 LEU A CB 1 ATOM 2439 C CG . LEU A 1 314 ? 41.207 -11.751 7.399 1.00 46.02 ? 314 LEU A CG 1 ATOM 2440 C CD1 . LEU A 1 314 ? 40.631 -10.352 7.227 1.00 45.68 ? 314 LEU A CD1 1 ATOM 2441 C CD2 . LEU A 1 314 ? 41.004 -12.228 8.829 1.00 48.48 ? 314 LEU A CD2 1 ATOM 2442 N N . VAL A 1 315 ? 42.199 -11.263 3.450 1.00 39.75 ? 315 VAL A N 1 ATOM 2443 C CA . VAL A 1 315 ? 43.434 -11.067 2.675 1.00 38.61 ? 315 VAL A CA 1 ATOM 2444 C C . VAL A 1 315 ? 44.309 -9.953 3.238 1.00 39.62 ? 315 VAL A C 1 ATOM 2445 O O . VAL A 1 315 ? 43.842 -8.845 3.480 1.00 38.51 ? 315 VAL A O 1 ATOM 2446 C CB . VAL A 1 315 ? 43.163 -10.865 1.152 1.00 43.21 ? 315 VAL A CB 1 ATOM 2447 C CG1 . VAL A 1 315 ? 44.455 -10.955 0.340 1.00 43.50 ? 315 VAL A CG1 1 ATOM 2448 C CG2 . VAL A 1 315 ? 42.139 -11.862 0.617 1.00 43.02 ? 315 VAL A CG2 1 ATOM 2449 N N . ASN A 1 316 ? 45.586 -10.253 3.422 1.00 36.68 ? 316 ASN A N 1 ATOM 2450 C CA . ASN A 1 316 ? 46.587 -9.308 3.902 1.00 37.63 ? 316 ASN A CA 1 ATOM 2451 C C . ASN A 1 316 ? 47.781 -9.529 3.002 1.00 43.79 ? 316 ASN A C 1 ATOM 2452 O O . ASN A 1 316 ? 48.492 -10.518 3.192 1.00 44.75 ? 316 ASN A O 1 ATOM 2453 C CB . ASN A 1 316 ? 46.990 -9.630 5.345 1.00 39.29 ? 316 ASN A CB 1 ATOM 2454 C CG . ASN A 1 316 ? 45.846 -9.734 6.301 1.00 59.86 ? 316 ASN A CG 1 ATOM 2455 O OD1 . ASN A 1 316 ? 45.170 -10.751 6.381 1.00 56.44 ? 316 ASN A OD1 1 ATOM 2456 N ND2 . ASN A 1 316 ? 45.627 -8.694 7.063 1.00 51.07 ? 316 ASN A ND2 1 ATOM 2457 N N . GLY A 1 317 ? 47.966 -8.671 1.999 1.00 39.81 ? 317 GLY A N 1 ATOM 2458 C CA . GLY A 1 317 ? 49.078 -8.792 1.059 1.00 39.36 ? 317 GLY A CA 1 ATOM 2459 C C . GLY A 1 317 ? 49.124 -10.131 0.350 1.00 42.97 ? 317 GLY A C 1 ATOM 2460 O O . GLY A 1 317 ? 48.354 -10.368 -0.574 1.00 44.31 ? 317 GLY A O 1 ATOM 2461 N N . ASP A 1 318 ? 49.988 -11.029 0.797 1.00 38.70 ? 318 ASP A N 1 ATOM 2462 C CA . ASP A 1 318 ? 50.093 -12.343 0.177 1.00 39.08 ? 318 ASP A CA 1 ATOM 2463 C C . ASP A 1 318 ? 49.483 -13.453 1.027 1.00 44.39 ? 318 ASP A C 1 ATOM 2464 O O . ASP A 1 318 ? 49.413 -14.591 0.558 1.00 44.52 ? 318 ASP A O 1 ATOM 2465 C CB . ASP A 1 318 ? 51.546 -12.663 -0.227 1.00 41.26 ? 318 ASP A CB 1 ATOM 2466 C CG . ASP A 1 318 ? 52.583 -12.761 0.888 1.00 53.49 ? 318 ASP A CG 1 ATOM 2467 O OD1 . ASP A 1 318 ? 52.334 -12.217 1.991 1.00 53.89 ? 318 ASP A OD1 1 ATOM 2468 O OD2 . ASP A 1 318 ? 53.670 -13.332 0.636 1.00 59.57 ? 318 ASP A OD2 1 ATOM 2469 N N . ASP A 1 319 ? 49.028 -13.128 2.263 1.00 41.04 ? 319 ASP A N 1 ATOM 2470 C CA . ASP A 1 319 ? 48.390 -14.096 3.149 1.00 40.93 ? 319 ASP A CA 1 ATOM 2471 C C . ASP A 1 319 ? 46.888 -14.105 2.963 1.00 43.55 ? 319 ASP A C 1 ATOM 2472 O O . ASP A 1 319 ? 46.246 -13.057 3.008 1.00 43.83 ? 319 ASP A O 1 ATOM 2473 C CB . ASP A 1 319 ? 48.772 -13.894 4.620 1.00 43.82 ? 319 ASP A CB 1 ATOM 2474 C CG . ASP A 1 319 ? 48.121 -14.913 5.552 1.00 65.86 ? 319 ASP A CG 1 ATOM 2475 O OD1 . ASP A 1 319 ? 48.572 -16.086 5.568 1.00 69.64 ? 319 ASP A OD1 1 ATOM 2476 O OD2 . ASP A 1 319 ? 47.138 -14.551 6.236 1.00 73.10 ? 319 ASP A OD2 1 ATOM 2477 N N . LEU A 1 320 ? 46.335 -15.304 2.754 1.00 39.20 ? 320 LEU A N 1 ATOM 2478 C CA . LEU A 1 320 ? 44.916 -15.530 2.537 1.00 38.58 ? 320 LEU A CA 1 ATOM 2479 C C . LEU A 1 320 ? 44.354 -16.531 3.539 1.00 43.40 ? 320 LEU A C 1 ATOM 2480 O O . LEU A 1 320 ? 44.935 -17.591 3.723 1.00 43.55 ? 320 LEU A O 1 ATOM 2481 C CB . LEU A 1 320 ? 44.705 -16.062 1.102 1.00 38.26 ? 320 LEU A CB 1 ATOM 2482 C CG . LEU A 1 320 ? 43.329 -16.642 0.776 1.00 42.67 ? 320 LEU A CG 1 ATOM 2483 C CD1 . LEU A 1 320 ? 42.341 -15.557 0.456 1.00 43.95 ? 320 LEU A CD1 1 ATOM 2484 C CD2 . LEU A 1 320 ? 43.400 -17.605 -0.338 1.00 42.72 ? 320 LEU A CD2 1 ATOM 2485 N N . VAL A 1 321 ? 43.209 -16.204 4.152 1.00 40.02 ? 321 VAL A N 1 ATOM 2486 C CA . VAL A 1 321 ? 42.442 -17.093 5.024 1.00 39.45 ? 321 VAL A CA 1 ATOM 2487 C C . VAL A 1 321 ? 41.016 -17.070 4.515 1.00 42.65 ? 321 VAL A C 1 ATOM 2488 O O . VAL A 1 321 ? 40.427 -15.986 4.408 1.00 43.36 ? 321 VAL A O 1 ATOM 2489 C CB . VAL A 1 321 ? 42.541 -16.764 6.540 1.00 43.51 ? 321 VAL A CB 1 ATOM 2490 C CG1 . VAL A 1 321 ? 41.335 -17.289 7.321 1.00 43.30 ? 321 VAL A CG1 1 ATOM 2491 C CG2 . VAL A 1 321 ? 43.814 -17.342 7.117 1.00 43.63 ? 321 VAL A CG2 1 ATOM 2492 N N . VAL A 1 322 ? 40.483 -18.255 4.170 1.00 37.85 ? 322 VAL A N 1 ATOM 2493 C CA . VAL A 1 322 ? 39.104 -18.441 3.714 1.00 37.94 ? 322 VAL A CA 1 ATOM 2494 C C . VAL A 1 322 ? 38.361 -19.312 4.737 1.00 43.38 ? 322 VAL A C 1 ATOM 2495 O O . VAL A 1 322 ? 38.911 -20.306 5.228 1.00 43.10 ? 322 VAL A O 1 ATOM 2496 C CB . VAL A 1 322 ? 39.009 -19.053 2.293 1.00 42.20 ? 322 VAL A CB 1 ATOM 2497 C CG1 . VAL A 1 322 ? 37.556 -19.186 1.827 1.00 42.12 ? 322 VAL A CG1 1 ATOM 2498 C CG2 . VAL A 1 322 ? 39.829 -18.260 1.277 1.00 42.22 ? 322 VAL A CG2 1 ATOM 2499 N N . ILE A 1 323 ? 37.132 -18.907 5.086 1.00 40.16 ? 323 ILE A N 1 ATOM 2500 C CA . ILE A 1 323 ? 36.234 -19.669 5.955 1.00 39.91 ? 323 ILE A CA 1 ATOM 2501 C C . ILE A 1 323 ? 34.944 -19.865 5.148 1.00 46.13 ? 323 ILE A C 1 ATOM 2502 O O . ILE A 1 323 ? 34.347 -18.890 4.680 1.00 46.01 ? 323 ILE A O 1 ATOM 2503 C CB . ILE A 1 323 ? 35.994 -19.059 7.362 1.00 42.43 ? 323 ILE A CB 1 ATOM 2504 C CG1 . ILE A 1 323 ? 37.314 -18.963 8.183 1.00 43.22 ? 323 ILE A CG1 1 ATOM 2505 C CG2 . ILE A 1 323 ? 34.921 -19.857 8.126 1.00 42.03 ? 323 ILE A CG2 1 ATOM 2506 C CD1 . ILE A 1 323 ? 37.279 -17.994 9.415 1.00 49.62 ? 323 ILE A CD1 1 ATOM 2507 N N . CYS A 1 324 ? 34.532 -21.131 4.976 1.00 43.48 ? 324 CYS A N 1 ATOM 2508 C CA . CYS A 1 324 ? 33.344 -21.499 4.201 1.00 43.01 ? 324 CYS A CA 1 ATOM 2509 C C . CYS A 1 324 ? 32.523 -22.653 4.834 1.00 48.85 ? 324 CYS A C 1 ATOM 2510 O O . CYS A 1 324 ? 32.716 -23.010 6.001 1.00 47.12 ? 324 CYS A O 1 ATOM 2511 C CB . CYS A 1 324 ? 33.747 -21.821 2.766 1.00 42.09 ? 324 CYS A CB 1 ATOM 2512 S SG . CYS A 1 324 ? 34.879 -23.223 2.620 1.00 45.23 ? 324 CYS A SG 1 ATOM 2513 N N . GLU A 1 325 ? 31.596 -23.217 4.042 1.00 47.66 ? 325 GLU A N 1 ATOM 2514 C CA . GLU A 1 325 ? 30.732 -24.325 4.442 1.00 47.53 ? 325 GLU A CA 1 ATOM 2515 C C . GLU A 1 325 ? 31.357 -25.646 4.005 1.00 52.62 ? 325 GLU A C 1 ATOM 2516 O O . GLU A 1 325 ? 31.600 -25.867 2.806 1.00 52.75 ? 325 GLU A O 1 ATOM 2517 C CB . GLU A 1 325 ? 29.310 -24.156 3.876 1.00 48.26 ? 325 GLU A CB 1 ATOM 2518 C CG . GLU A 1 325 ? 28.501 -23.067 4.558 1.00 51.75 ? 325 GLU A CG 1 ATOM 2519 C CD . GLU A 1 325 ? 27.906 -23.393 5.917 1.00 62.25 ? 325 GLU A CD 1 ATOM 2520 O OE1 . GLU A 1 325 ? 27.246 -22.493 6.485 1.00 55.17 ? 325 GLU A OE1 1 ATOM 2521 O OE2 . GLU A 1 325 ? 28.081 -24.533 6.411 1.00 50.31 ? 325 GLU A OE2 1 ATOM 2522 N N . SER A 1 326 ? 31.646 -26.502 5.000 1.00 48.64 ? 326 SER A N 1 ATOM 2523 C CA . SER A 1 326 ? 32.256 -27.825 4.844 1.00 48.43 ? 326 SER A CA 1 ATOM 2524 C C . SER A 1 326 ? 31.310 -28.773 4.102 1.00 52.17 ? 326 SER A C 1 ATOM 2525 O O . SER A 1 326 ? 30.093 -28.611 4.191 1.00 53.81 ? 326 SER A O 1 ATOM 2526 C CB . SER A 1 326 ? 32.583 -28.392 6.223 1.00 52.07 ? 326 SER A CB 1 ATOM 2527 O OG . SER A 1 326 ? 33.213 -29.659 6.175 1.00 61.43 ? 326 SER A OG 1 ATOM 2528 N N . ALA A 1 327 ? 31.864 -29.749 3.377 1.00 46.75 ? 327 ALA A N 1 ATOM 2529 C CA . ALA A 1 327 ? 31.121 -30.787 2.646 1.00 45.88 ? 327 ALA A CA 1 ATOM 2530 C C . ALA A 1 327 ? 31.749 -32.176 2.953 1.00 50.78 ? 327 ALA A C 1 ATOM 2531 O O . ALA A 1 327 ? 31.722 -33.097 2.125 1.00 51.20 ? 327 ALA A O 1 ATOM 2532 C CB . ALA A 1 327 ? 31.143 -30.497 1.153 1.00 45.97 ? 327 ALA A CB 1 ATOM 2533 N N . GLY A 1 328 ? 32.307 -32.298 4.159 1.00 46.29 ? 328 GLY A N 1 ATOM 2534 C CA . GLY A 1 328 ? 33.006 -33.491 4.613 1.00 45.85 ? 328 GLY A CA 1 ATOM 2535 C C . GLY A 1 328 ? 34.465 -33.411 4.218 1.00 48.96 ? 328 GLY A C 1 ATOM 2536 O O . GLY A 1 328 ? 34.790 -32.825 3.179 1.00 50.40 ? 328 GLY A O 1 ATOM 2537 N N . THR A 1 329 ? 35.354 -34.004 5.029 1.00 42.17 ? 329 THR A N 1 ATOM 2538 C CA . THR A 1 329 ? 36.809 -33.963 4.830 1.00 40.81 ? 329 THR A CA 1 ATOM 2539 C C . THR A 1 329 ? 37.314 -34.325 3.415 1.00 42.27 ? 329 THR A C 1 ATOM 2540 O O . THR A 1 329 ? 38.321 -33.756 2.997 1.00 42.38 ? 329 THR A O 1 ATOM 2541 C CB . THR A 1 329 ? 37.540 -34.814 5.864 1.00 48.19 ? 329 THR A CB 1 ATOM 2542 O OG1 . THR A 1 329 ? 37.095 -36.162 5.753 1.00 54.71 ? 329 THR A OG1 1 ATOM 2543 C CG2 . THR A 1 329 ? 37.349 -34.320 7.279 1.00 43.91 ? 329 THR A CG2 1 ATOM 2544 N N . GLN A 1 330 ? 36.640 -35.253 2.690 1.00 36.31 ? 330 GLN A N 1 ATOM 2545 C CA . GLN A 1 330 ? 37.074 -35.713 1.355 1.00 34.32 ? 330 GLN A CA 1 ATOM 2546 C C . GLN A 1 330 ? 36.685 -34.755 0.240 1.00 37.84 ? 330 GLN A C 1 ATOM 2547 O O . GLN A 1 330 ? 37.510 -34.488 -0.642 1.00 38.59 ? 330 GLN A O 1 ATOM 2548 C CB . GLN A 1 330 ? 36.618 -37.156 1.049 1.00 34.59 ? 330 GLN A CB 1 ATOM 2549 C CG . GLN A 1 330 ? 37.064 -38.226 2.054 1.00 43.23 ? 330 GLN A CG 1 ATOM 2550 C CD . GLN A 1 330 ? 38.542 -38.225 2.392 1.00 70.18 ? 330 GLN A CD 1 ATOM 2551 O OE1 . GLN A 1 330 ? 38.969 -37.635 3.396 1.00 67.50 ? 330 GLN A OE1 1 ATOM 2552 N NE2 . GLN A 1 330 ? 39.347 -38.954 1.621 1.00 61.22 ? 330 GLN A NE2 1 ATOM 2553 N N . GLU A 1 331 ? 35.450 -34.214 0.281 1.00 33.20 ? 331 GLU A N 1 ATOM 2554 C CA . GLU A 1 331 ? 34.986 -33.238 -0.705 1.00 33.17 ? 331 GLU A CA 1 ATOM 2555 C C . GLU A 1 331 ? 35.724 -31.911 -0.491 1.00 37.29 ? 331 GLU A C 1 ATOM 2556 O O . GLU A 1 331 ? 36.059 -31.232 -1.457 1.00 35.49 ? 331 GLU A O 1 ATOM 2557 C CB . GLU A 1 331 ? 33.449 -33.053 -0.650 1.00 34.40 ? 331 GLU A CB 1 ATOM 2558 C CG . GLU A 1 331 ? 32.852 -32.277 -1.821 1.00 41.14 ? 331 GLU A CG 1 ATOM 2559 C CD . GLU A 1 331 ? 33.174 -32.814 -3.209 1.00 55.82 ? 331 GLU A CD 1 ATOM 2560 O OE1 . GLU A 1 331 ? 33.189 -34.056 -3.371 1.00 35.39 ? 331 GLU A OE1 1 ATOM 2561 O OE2 . GLU A 1 331 ? 33.434 -32.001 -4.127 1.00 48.55 ? 331 GLU A OE2 1 ATOM 2562 N N . ASP A 1 332 ? 36.000 -31.567 0.779 1.00 35.66 ? 332 ASP A N 1 ATOM 2563 C CA . ASP A 1 332 ? 36.762 -30.377 1.140 1.00 35.82 ? 332 ASP A CA 1 ATOM 2564 C C . ASP A 1 332 ? 38.189 -30.500 0.635 1.00 40.44 ? 332 ASP A C 1 ATOM 2565 O O . ASP A 1 332 ? 38.713 -29.527 0.107 1.00 41.21 ? 332 ASP A O 1 ATOM 2566 C CB . ASP A 1 332 ? 36.749 -30.136 2.653 1.00 37.49 ? 332 ASP A CB 1 ATOM 2567 C CG . ASP A 1 332 ? 35.415 -29.679 3.195 1.00 48.18 ? 332 ASP A CG 1 ATOM 2568 O OD1 . ASP A 1 332 ? 34.510 -29.384 2.380 1.00 49.31 ? 332 ASP A OD1 1 ATOM 2569 O OD2 . ASP A 1 332 ? 35.275 -29.610 4.432 1.00 53.87 ? 332 ASP A OD2 1 ATOM 2570 N N . ALA A 1 333 ? 38.805 -31.696 0.753 1.00 36.64 ? 333 ALA A N 1 ATOM 2571 C CA . ALA A 1 333 ? 40.166 -31.942 0.273 1.00 35.95 ? 333 ALA A CA 1 ATOM 2572 C C . ALA A 1 333 ? 40.188 -31.852 -1.242 1.00 39.61 ? 333 ALA A C 1 ATOM 2573 O O . ALA A 1 333 ? 41.161 -31.360 -1.813 1.00 39.52 ? 333 ALA A O 1 ATOM 2574 C CB . ALA A 1 333 ? 40.650 -33.306 0.731 1.00 36.47 ? 333 ALA A CB 1 ATOM 2575 N N . ALA A 1 334 ? 39.086 -32.286 -1.884 1.00 36.30 ? 334 ALA A N 1 ATOM 2576 C CA . ALA A 1 334 ? 38.895 -32.254 -3.334 1.00 35.61 ? 334 ALA A CA 1 ATOM 2577 C C . ALA A 1 334 ? 38.803 -30.793 -3.812 1.00 40.17 ? 334 ALA A C 1 ATOM 2578 O O . ALA A 1 334 ? 39.572 -30.379 -4.677 1.00 39.32 ? 334 ALA A O 1 ATOM 2579 C CB . ALA A 1 334 ? 37.638 -33.021 -3.696 1.00 36.09 ? 334 ALA A CB 1 ATOM 2580 N N . SER A 1 335 ? 37.912 -30.002 -3.176 1.00 38.19 ? 335 SER A N 1 ATOM 2581 C CA . SER A 1 335 ? 37.677 -28.581 -3.435 1.00 38.17 ? 335 SER A CA 1 ATOM 2582 C C . SER A 1 335 ? 38.978 -27.783 -3.382 1.00 43.60 ? 335 SER A C 1 ATOM 2583 O O . SER A 1 335 ? 39.202 -26.952 -4.263 1.00 43.07 ? 335 SER A O 1 ATOM 2584 C CB . SER A 1 335 ? 36.696 -28.017 -2.413 1.00 40.90 ? 335 SER A CB 1 ATOM 2585 O OG . SER A 1 335 ? 35.466 -28.720 -2.419 1.00 51.31 ? 335 SER A OG 1 ATOM 2586 N N . LEU A 1 336 ? 39.822 -28.018 -2.338 1.00 41.07 ? 336 LEU A N 1 ATOM 2587 C CA . LEU A 1 336 ? 41.102 -27.335 -2.151 1.00 41.24 ? 336 LEU A CA 1 ATOM 2588 C C . LEU A 1 336 ? 42.075 -27.672 -3.269 1.00 47.77 ? 336 LEU A C 1 ATOM 2589 O O . LEU A 1 336 ? 42.866 -26.797 -3.637 1.00 48.77 ? 336 LEU A O 1 ATOM 2590 C CB . LEU A 1 336 ? 41.739 -27.580 -0.761 1.00 41.05 ? 336 LEU A CB 1 ATOM 2591 C CG . LEU A 1 336 ? 40.992 -27.119 0.502 1.00 45.11 ? 336 LEU A CG 1 ATOM 2592 C CD1 . LEU A 1 336 ? 41.938 -26.983 1.674 1.00 44.14 ? 336 LEU A CD1 1 ATOM 2593 C CD2 . LEU A 1 336 ? 40.278 -25.804 0.290 1.00 49.33 ? 336 LEU A CD2 1 ATOM 2594 N N . ARG A 1 337 ? 42.012 -28.911 -3.837 1.00 43.14 ? 337 ARG A N 1 ATOM 2595 C CA . ARG A 1 337 ? 42.873 -29.276 -4.970 1.00 42.27 ? 337 ARG A CA 1 ATOM 2596 C C . ARG A 1 337 ? 42.454 -28.456 -6.153 1.00 45.03 ? 337 ARG A C 1 ATOM 2597 O O . ARG A 1 337 ? 43.327 -27.918 -6.820 1.00 45.99 ? 337 ARG A O 1 ATOM 2598 C CB . ARG A 1 337 ? 42.826 -30.767 -5.324 1.00 42.82 ? 337 ARG A CB 1 ATOM 2599 C CG . ARG A 1 337 ? 43.439 -31.658 -4.242 1.00 54.83 ? 337 ARG A CG 1 ATOM 2600 C CD . ARG A 1 337 ? 43.846 -33.038 -4.731 1.00 63.30 ? 337 ARG A CD 1 ATOM 2601 N NE . ARG A 1 337 ? 42.882 -34.108 -4.437 1.00 77.35 ? 337 ARG A NE 1 ATOM 2602 C CZ . ARG A 1 337 ? 42.929 -34.904 -3.370 1.00 96.09 ? 337 ARG A CZ 1 ATOM 2603 N NH1 . ARG A 1 337 ? 43.900 -34.768 -2.471 1.00 84.44 ? 337 ARG A NH1 1 ATOM 2604 N NH2 . ARG A 1 337 ? 42.007 -35.838 -3.193 1.00 85.40 ? 337 ARG A NH2 1 ATOM 2605 N N . VAL A 1 338 ? 41.117 -28.289 -6.362 1.00 38.80 ? 338 VAL A N 1 ATOM 2606 C CA . VAL A 1 338 ? 40.517 -27.485 -7.441 1.00 37.09 ? 338 VAL A CA 1 ATOM 2607 C C . VAL A 1 338 ? 40.955 -26.022 -7.261 1.00 39.16 ? 338 VAL A C 1 ATOM 2608 O O . VAL A 1 338 ? 41.350 -25.369 -8.230 1.00 40.40 ? 338 VAL A O 1 ATOM 2609 C CB . VAL A 1 338 ? 38.967 -27.634 -7.490 1.00 40.15 ? 338 VAL A CB 1 ATOM 2610 C CG1 . VAL A 1 338 ? 38.350 -26.799 -8.609 1.00 39.46 ? 338 VAL A CG1 1 ATOM 2611 C CG2 . VAL A 1 338 ? 38.552 -29.100 -7.610 1.00 39.83 ? 338 VAL A CG2 1 ATOM 2612 N N . PHE A 1 339 ? 40.940 -25.541 -6.014 1.00 33.05 ? 339 PHE A N 1 ATOM 2613 C CA . PHE A 1 339 ? 41.355 -24.189 -5.655 1.00 32.49 ? 339 PHE A CA 1 ATOM 2614 C C . PHE A 1 339 ? 42.847 -23.964 -5.985 1.00 37.50 ? 339 PHE A C 1 ATOM 2615 O O . PHE A 1 339 ? 43.191 -22.972 -6.637 1.00 38.08 ? 339 PHE A O 1 ATOM 2616 C CB . PHE A 1 339 ? 41.053 -23.944 -4.176 1.00 33.81 ? 339 PHE A CB 1 ATOM 2617 C CG . PHE A 1 339 ? 41.469 -22.603 -3.637 1.00 34.60 ? 339 PHE A CG 1 ATOM 2618 C CD1 . PHE A 1 339 ? 40.625 -21.503 -3.738 1.00 36.54 ? 339 PHE A CD1 1 ATOM 2619 C CD2 . PHE A 1 339 ? 42.678 -22.452 -2.967 1.00 35.46 ? 339 PHE A CD2 1 ATOM 2620 C CE1 . PHE A 1 339 ? 41.012 -20.263 -3.240 1.00 36.85 ? 339 PHE A CE1 1 ATOM 2621 C CE2 . PHE A 1 339 ? 43.055 -21.215 -2.453 1.00 37.92 ? 339 PHE A CE2 1 ATOM 2622 C CZ . PHE A 1 339 ? 42.218 -20.129 -2.594 1.00 36.01 ? 339 PHE A CZ 1 ATOM 2623 N N . THR A 1 340 ? 43.712 -24.917 -5.584 1.00 33.40 ? 340 THR A N 1 ATOM 2624 C CA . THR A 1 340 ? 45.163 -24.910 -5.826 1.00 32.65 ? 340 THR A CA 1 ATOM 2625 C C . THR A 1 340 ? 45.450 -25.002 -7.334 1.00 36.78 ? 340 THR A C 1 ATOM 2626 O O . THR A 1 340 ? 46.433 -24.426 -7.791 1.00 36.00 ? 340 THR A O 1 ATOM 2627 C CB . THR A 1 340 ? 45.806 -26.035 -5.005 1.00 40.45 ? 340 THR A CB 1 ATOM 2628 O OG1 . THR A 1 340 ? 45.437 -25.883 -3.634 1.00 43.79 ? 340 THR A OG1 1 ATOM 2629 C CG2 . THR A 1 340 ? 47.303 -26.085 -5.124 1.00 37.56 ? 340 THR A CG2 1 ATOM 2630 N N . GLU A 1 341 ? 44.583 -25.718 -8.103 1.00 34.20 ? 341 GLU A N 1 ATOM 2631 C CA . GLU A 1 341 ? 44.692 -25.859 -9.560 1.00 34.68 ? 341 GLU A CA 1 ATOM 2632 C C . GLU A 1 341 ? 44.409 -24.499 -10.196 1.00 36.19 ? 341 GLU A C 1 ATOM 2633 O O . GLU A 1 341 ? 45.194 -24.038 -11.016 1.00 35.21 ? 341 GLU A O 1 ATOM 2634 C CB . GLU A 1 341 ? 43.699 -26.912 -10.095 1.00 37.01 ? 341 GLU A CB 1 ATOM 2635 C CG . GLU A 1 341 ? 44.135 -28.360 -9.908 1.00 53.54 ? 341 GLU A CG 1 ATOM 2636 C CD . GLU A 1 341 ? 43.132 -29.429 -10.318 1.00 69.71 ? 341 GLU A CD 1 ATOM 2637 O OE1 . GLU A 1 341 ? 42.730 -30.223 -9.438 1.00 46.69 ? 341 GLU A OE1 1 ATOM 2638 O OE2 . GLU A 1 341 ? 42.775 -29.498 -11.518 1.00 62.49 ? 341 GLU A OE2 1 ATOM 2639 N N . ALA A 1 342 ? 43.303 -23.842 -9.770 1.00 31.77 ? 342 ALA A N 1 ATOM 2640 C CA . ALA A 1 342 ? 42.887 -22.523 -10.233 1.00 31.08 ? 342 ALA A CA 1 ATOM 2641 C C . ALA A 1 342 ? 43.957 -21.473 -9.933 1.00 35.96 ? 342 ALA A C 1 ATOM 2642 O O . ALA A 1 342 ? 44.358 -20.743 -10.847 1.00 34.50 ? 342 ALA A O 1 ATOM 2643 C CB . ALA A 1 342 ? 41.576 -22.140 -9.583 1.00 31.44 ? 342 ALA A CB 1 ATOM 2644 N N . MET A 1 343 ? 44.465 -21.439 -8.664 1.00 33.66 ? 343 MET A N 1 ATOM 2645 C CA . MET A 1 343 ? 45.501 -20.497 -8.206 1.00 33.04 ? 343 MET A CA 1 ATOM 2646 C C . MET A 1 343 ? 46.783 -20.599 -9.044 1.00 37.76 ? 343 MET A C 1 ATOM 2647 O O . MET A 1 343 ? 47.336 -19.569 -9.429 1.00 38.30 ? 343 MET A O 1 ATOM 2648 C CB . MET A 1 343 ? 45.796 -20.675 -6.712 1.00 34.88 ? 343 MET A CB 1 ATOM 2649 C CG . MET A 1 343 ? 44.685 -20.182 -5.795 1.00 37.85 ? 343 MET A CG 1 ATOM 2650 S SD . MET A 1 343 ? 44.292 -18.423 -5.923 1.00 41.20 ? 343 MET A SD 1 ATOM 2651 C CE . MET A 1 343 ? 45.492 -17.749 -4.843 1.00 37.47 ? 343 MET A CE 1 ATOM 2652 N N . THR A 1 344 ? 47.212 -21.840 -9.368 1.00 33.11 ? 344 THR A N 1 ATOM 2653 C CA . THR A 1 344 ? 48.380 -22.165 -10.199 1.00 32.16 ? 344 THR A CA 1 ATOM 2654 C C . THR A 1 344 ? 48.159 -21.682 -11.637 1.00 36.59 ? 344 THR A C 1 ATOM 2655 O O . THR A 1 344 ? 49.113 -21.211 -12.265 1.00 37.04 ? 344 THR A O 1 ATOM 2656 C CB . THR A 1 344 ? 48.677 -23.672 -10.116 1.00 33.13 ? 344 THR A CB 1 ATOM 2657 O OG1 . THR A 1 344 ? 48.935 -24.020 -8.757 1.00 31.96 ? 344 THR A OG1 1 ATOM 2658 C CG2 . THR A 1 344 ? 49.841 -24.103 -10.986 1.00 28.63 ? 344 THR A CG2 1 ATOM 2659 N N . ARG A 1 345 ? 46.907 -21.796 -12.160 1.00 32.80 ? 345 ARG A N 1 ATOM 2660 C CA . ARG A 1 345 ? 46.546 -21.332 -13.513 1.00 32.44 ? 345 ARG A CA 1 ATOM 2661 C C . ARG A 1 345 ? 46.639 -19.819 -13.591 1.00 35.69 ? 345 ARG A C 1 ATOM 2662 O O . ARG A 1 345 ? 47.061 -19.268 -14.608 1.00 33.27 ? 345 ARG A O 1 ATOM 2663 C CB . ARG A 1 345 ? 45.139 -21.778 -13.915 1.00 32.04 ? 345 ARG A CB 1 ATOM 2664 C CG . ARG A 1 345 ? 45.064 -23.244 -14.325 1.00 41.33 ? 345 ARG A CG 1 ATOM 2665 C CD . ARG A 1 345 ? 43.782 -23.534 -15.082 1.00 49.03 ? 345 ARG A CD 1 ATOM 2666 N NE . ARG A 1 345 ? 42.605 -23.518 -14.214 1.00 57.79 ? 345 ARG A NE 1 ATOM 2667 C CZ . ARG A 1 345 ? 42.095 -24.597 -13.625 1.00 75.89 ? 345 ARG A CZ 1 ATOM 2668 N NH1 . ARG A 1 345 ? 42.660 -25.786 -13.798 1.00 71.08 ? 345 ARG A NH1 1 ATOM 2669 N NH2 . ARG A 1 345 ? 41.016 -24.496 -12.859 1.00 59.45 ? 345 ARG A NH2 1 ATOM 2670 N N . TYR A 1 346 ? 46.297 -19.155 -12.476 1.00 33.90 ? 346 TYR A N 1 ATOM 2671 C CA . TYR A 1 346 ? 46.328 -17.705 -12.339 1.00 33.15 ? 346 TYR A CA 1 ATOM 2672 C C . TYR A 1 346 ? 47.724 -17.189 -12.075 1.00 40.13 ? 346 TYR A C 1 ATOM 2673 O O . TYR A 1 346 ? 47.883 -15.981 -11.960 1.00 41.91 ? 346 TYR A O 1 ATOM 2674 C CB . TYR A 1 346 ? 45.389 -17.259 -11.207 1.00 32.34 ? 346 TYR A CB 1 ATOM 2675 C CG . TYR A 1 346 ? 43.919 -17.563 -11.407 1.00 31.10 ? 346 TYR A CG 1 ATOM 2676 C CD1 . TYR A 1 346 ? 43.335 -17.490 -12.671 1.00 32.25 ? 346 TYR A CD1 1 ATOM 2677 C CD2 . TYR A 1 346 ? 43.084 -17.789 -10.319 1.00 31.14 ? 346 TYR A CD2 1 ATOM 2678 C CE1 . TYR A 1 346 ? 41.976 -17.724 -12.854 1.00 32.44 ? 346 TYR A CE1 1 ATOM 2679 C CE2 . TYR A 1 346 ? 41.723 -18.016 -10.487 1.00 31.77 ? 346 TYR A CE2 1 ATOM 2680 C CZ . TYR A 1 346 ? 41.172 -17.981 -11.756 1.00 40.16 ? 346 TYR A CZ 1 ATOM 2681 O OH . TYR A 1 346 ? 39.834 -18.227 -11.916 1.00 43.24 ? 346 TYR A OH 1 ATOM 2682 N N . SER A 1 347 ? 48.740 -18.086 -11.991 1.00 36.90 ? 347 SER A N 1 ATOM 2683 C CA . SER A 1 347 ? 50.147 -17.771 -11.706 1.00 36.61 ? 347 SER A CA 1 ATOM 2684 C C . SER A 1 347 ? 50.313 -17.328 -10.266 1.00 42.63 ? 347 SER A C 1 ATOM 2685 O O . SER A 1 347 ? 50.776 -16.219 -9.995 1.00 43.26 ? 347 SER A O 1 ATOM 2686 C CB . SER A 1 347 ? 50.719 -16.755 -12.688 1.00 39.87 ? 347 SER A CB 1 ATOM 2687 O OG . SER A 1 347 ? 52.034 -16.374 -12.320 1.00 50.92 ? 347 SER A OG 1 ATOM 2688 N N . ALA A 1 348 ? 49.862 -18.194 -9.343 1.00 39.79 ? 348 ALA A N 1 ATOM 2689 C CA . ALA A 1 348 ? 49.960 -18.060 -7.890 1.00 40.26 ? 348 ALA A CA 1 ATOM 2690 C C . ALA A 1 348 ? 49.982 -19.484 -7.283 1.00 46.57 ? 348 ALA A C 1 ATOM 2691 O O . ALA A 1 348 ? 49.077 -19.832 -6.520 1.00 46.14 ? 348 ALA A O 1 ATOM 2692 C CB . ALA A 1 348 ? 48.790 -17.249 -7.342 1.00 40.94 ? 348 ALA A CB 1 ATOM 2693 N N . PRO A 1 349 ? 50.982 -20.342 -7.626 1.00 45.25 ? 349 PRO A N 1 ATOM 2694 C CA . PRO A 1 349 ? 50.998 -21.701 -7.055 1.00 46.51 ? 349 PRO A CA 1 ATOM 2695 C C . PRO A 1 349 ? 51.452 -21.705 -5.588 1.00 55.13 ? 349 PRO A C 1 ATOM 2696 O O . PRO A 1 349 ? 52.003 -20.699 -5.140 1.00 54.11 ? 349 PRO A O 1 ATOM 2697 C CB . PRO A 1 349 ? 51.973 -22.448 -7.965 1.00 47.84 ? 349 PRO A CB 1 ATOM 2698 C CG . PRO A 1 349 ? 52.913 -21.406 -8.434 1.00 51.17 ? 349 PRO A CG 1 ATOM 2699 C CD . PRO A 1 349 ? 52.147 -20.123 -8.513 1.00 46.39 ? 349 PRO A CD 1 ATOM 2700 N N . PRO A 1 350 ? 51.286 -22.810 -4.815 1.00 56.43 ? 350 PRO A N 1 ATOM 2701 C CA . PRO A 1 350 ? 51.688 -22.764 -3.399 1.00 57.14 ? 350 PRO A CA 1 ATOM 2702 C C . PRO A 1 350 ? 53.037 -23.400 -3.079 1.00 60.61 ? 350 PRO A C 1 ATOM 2703 O O . PRO A 1 350 ? 53.616 -24.098 -3.914 1.00 60.05 ? 350 PRO A O 1 ATOM 2704 C CB . PRO A 1 350 ? 50.569 -23.552 -2.719 1.00 59.26 ? 350 PRO A CB 1 ATOM 2705 C CG . PRO A 1 350 ? 50.230 -24.637 -3.752 1.00 63.68 ? 350 PRO A CG 1 ATOM 2706 C CD . PRO A 1 350 ? 50.631 -24.104 -5.128 1.00 58.93 ? 350 PRO A CD 1 ATOM 2707 N N . GLY A 1 351 ? 53.492 -23.170 -1.851 1.00 57.07 ? 351 GLY A N 1 ATOM 2708 C CA . GLY A 1 351 ? 54.704 -23.772 -1.313 1.00 57.42 ? 351 GLY A CA 1 ATOM 2709 C C . GLY A 1 351 ? 54.288 -25.103 -0.735 1.00 62.07 ? 351 GLY A C 1 ATOM 2710 O O . GLY A 1 351 ? 54.736 -26.159 -1.187 1.00 61.22 ? 351 GLY A O 1 ATOM 2711 N N . ASP A 1 352 ? 53.379 -25.034 0.253 1.00 59.76 ? 352 ASP A N 1 ATOM 2712 C CA . ASP A 1 352 ? 52.709 -26.162 0.888 1.00 59.78 ? 352 ASP A CA 1 ATOM 2713 C C . ASP A 1 352 ? 51.211 -26.016 0.526 1.00 62.76 ? 352 ASP A C 1 ATOM 2714 O O . ASP A 1 352 ? 50.624 -24.944 0.765 1.00 61.57 ? 352 ASP A O 1 ATOM 2715 C CB . ASP A 1 352 ? 52.936 -26.181 2.419 1.00 61.84 ? 352 ASP A CB 1 ATOM 2716 C CG . ASP A 1 352 ? 54.129 -27.012 2.873 1.00 70.37 ? 352 ASP A CG 1 ATOM 2717 O OD1 . ASP A 1 352 ? 54.217 -28.201 2.473 1.00 71.23 ? 352 ASP A OD1 1 ATOM 2718 O OD2 . ASP A 1 352 ? 54.953 -26.490 3.657 1.00 72.23 ? 352 ASP A OD2 1 ATOM 2719 N N . PRO A 1 353 ? 50.597 -27.039 -0.129 1.00 58.57 ? 353 PRO A N 1 ATOM 2720 C CA . PRO A 1 353 ? 49.181 -26.905 -0.510 1.00 57.71 ? 353 PRO A CA 1 ATOM 2721 C C . PRO A 1 353 ? 48.243 -26.832 0.709 1.00 59.13 ? 353 PRO A C 1 ATOM 2722 O O . PRO A 1 353 ? 48.560 -27.428 1.748 1.00 57.60 ? 353 PRO A O 1 ATOM 2723 C CB . PRO A 1 353 ? 48.934 -28.107 -1.423 1.00 59.73 ? 353 PRO A CB 1 ATOM 2724 C CG . PRO A 1 353 ? 49.959 -29.102 -1.036 1.00 64.42 ? 353 PRO A CG 1 ATOM 2725 C CD . PRO A 1 353 ? 51.145 -28.358 -0.511 1.00 59.98 ? 353 PRO A CD 1 ATOM 2726 N N . PRO A 1 354 ? 47.139 -26.037 0.635 1.00 54.68 ? 354 PRO A N 1 ATOM 2727 C CA . PRO A 1 354 ? 46.259 -25.872 1.808 1.00 53.84 ? 354 PRO A CA 1 ATOM 2728 C C . PRO A 1 354 ? 45.578 -27.143 2.304 1.00 58.33 ? 354 PRO A C 1 ATOM 2729 O O . PRO A 1 354 ? 45.218 -28.016 1.503 1.00 59.15 ? 354 PRO A O 1 ATOM 2730 C CB . PRO A 1 354 ? 45.237 -24.830 1.343 1.00 55.12 ? 354 PRO A CB 1 ATOM 2731 C CG . PRO A 1 354 ? 45.228 -24.950 -0.138 1.00 59.60 ? 354 PRO A CG 1 ATOM 2732 C CD . PRO A 1 354 ? 46.649 -25.240 -0.508 1.00 55.62 ? 354 PRO A CD 1 ATOM 2733 N N . GLN A 1 355 ? 45.387 -27.220 3.630 1.00 53.36 ? 355 GLN A N 1 ATOM 2734 C CA . GLN A 1 355 ? 44.724 -28.322 4.321 1.00 52.41 ? 355 GLN A CA 1 ATOM 2735 C C . GLN A 1 355 ? 43.453 -27.836 5.022 1.00 52.76 ? 355 GLN A C 1 ATOM 2736 O O . GLN A 1 355 ? 43.490 -26.790 5.677 1.00 52.21 ? 355 GLN A O 1 ATOM 2737 C CB . GLN A 1 355 ? 45.672 -28.975 5.338 1.00 54.09 ? 355 GLN A CB 1 ATOM 2738 C CG . GLN A 1 355 ? 46.562 -30.068 4.743 1.00 75.90 ? 355 GLN A CG 1 ATOM 2739 C CD . GLN A 1 355 ? 47.504 -30.650 5.773 1.00 105.32 ? 355 GLN A CD 1 ATOM 2740 O OE1 . GLN A 1 355 ? 47.114 -31.013 6.898 1.00 102.14 ? 355 GLN A OE1 1 ATOM 2741 N NE2 . GLN A 1 355 ? 48.773 -30.766 5.403 1.00 99.65 ? 355 GLN A NE2 1 ATOM 2742 N N . PRO A 1 356 ? 42.322 -28.575 4.901 1.00 47.05 ? 356 PRO A N 1 ATOM 2743 C CA . PRO A 1 356 ? 41.093 -28.145 5.584 1.00 45.78 ? 356 PRO A CA 1 ATOM 2744 C C . PRO A 1 356 ? 41.199 -28.289 7.097 1.00 46.44 ? 356 PRO A C 1 ATOM 2745 O O . PRO A 1 356 ? 41.672 -29.306 7.612 1.00 44.86 ? 356 PRO A O 1 ATOM 2746 C CB . PRO A 1 356 ? 40.003 -29.051 4.998 1.00 47.92 ? 356 PRO A CB 1 ATOM 2747 C CG . PRO A 1 356 ? 40.651 -29.828 3.892 1.00 52.89 ? 356 PRO A CG 1 ATOM 2748 C CD . PRO A 1 356 ? 42.115 -29.843 4.175 1.00 48.47 ? 356 PRO A CD 1 ATOM 2749 N N . GLU A 1 357 ? 40.808 -27.226 7.796 1.00 42.13 ? 357 GLU A N 1 ATOM 2750 C CA . GLU A 1 357 ? 40.820 -27.145 9.248 1.00 41.63 ? 357 GLU A CA 1 ATOM 2751 C C . GLU A 1 357 ? 39.397 -26.985 9.748 1.00 44.43 ? 357 GLU A C 1 ATOM 2752 O O . GLU A 1 357 ? 38.604 -26.245 9.148 1.00 43.40 ? 357 GLU A O 1 ATOM 2753 C CB . GLU A 1 357 ? 41.744 -26.028 9.747 1.00 42.86 ? 357 GLU A CB 1 ATOM 2754 C CG . GLU A 1 357 ? 43.219 -26.242 9.419 1.00 51.73 ? 357 GLU A CG 1 ATOM 2755 C CD . GLU A 1 357 ? 43.916 -27.460 10.010 1.00 74.71 ? 357 GLU A CD 1 ATOM 2756 O OE1 . GLU A 1 357 ? 43.460 -27.971 11.059 1.00 64.73 ? 357 GLU A OE1 1 ATOM 2757 O OE2 . GLU A 1 357 ? 44.934 -27.896 9.425 1.00 74.52 ? 357 GLU A OE2 1 ATOM 2758 N N . TYR A 1 358 ? 39.060 -27.744 10.805 1.00 40.13 ? 358 TYR A N 1 ATOM 2759 C CA . TYR A 1 358 ? 37.715 -27.812 11.370 1.00 39.56 ? 358 TYR A CA 1 ATOM 2760 C C . TYR A 1 358 ? 37.653 -27.206 12.766 1.00 44.66 ? 358 TYR A C 1 ATOM 2761 O O . TYR A 1 358 ? 36.634 -27.272 13.460 1.00 42.49 ? 358 TYR A O 1 ATOM 2762 C CB . TYR A 1 358 ? 37.208 -29.266 11.301 1.00 39.60 ? 358 TYR A CB 1 ATOM 2763 C CG . TYR A 1 358 ? 37.183 -29.762 9.875 1.00 40.14 ? 358 TYR A CG 1 ATOM 2764 C CD1 . TYR A 1 358 ? 36.116 -29.464 9.033 1.00 41.95 ? 358 TYR A CD1 1 ATOM 2765 C CD2 . TYR A 1 358 ? 38.274 -30.437 9.334 1.00 40.71 ? 358 TYR A CD2 1 ATOM 2766 C CE1 . TYR A 1 358 ? 36.120 -29.855 7.700 1.00 42.91 ? 358 TYR A CE1 1 ATOM 2767 C CE2 . TYR A 1 358 ? 38.299 -30.813 7.996 1.00 41.31 ? 358 TYR A CE2 1 ATOM 2768 C CZ . TYR A 1 358 ? 37.217 -30.522 7.184 1.00 48.30 ? 358 TYR A CZ 1 ATOM 2769 O OH . TYR A 1 358 ? 37.226 -30.894 5.866 1.00 47.98 ? 358 TYR A OH 1 ATOM 2770 N N . ASP A 1 359 ? 38.737 -26.526 13.121 1.00 43.97 ? 359 ASP A N 1 ATOM 2771 C CA . ASP A 1 359 ? 38.915 -25.837 14.386 1.00 44.78 ? 359 ASP A CA 1 ATOM 2772 C C . ASP A 1 359 ? 39.645 -24.550 14.065 1.00 47.92 ? 359 ASP A C 1 ATOM 2773 O O . ASP A 1 359 ? 40.732 -24.590 13.479 1.00 47.08 ? 359 ASP A O 1 ATOM 2774 C CB . ASP A 1 359 ? 39.724 -26.718 15.367 1.00 47.59 ? 359 ASP A CB 1 ATOM 2775 C CG . ASP A 1 359 ? 40.071 -26.080 16.695 1.00 64.91 ? 359 ASP A CG 1 ATOM 2776 O OD1 . ASP A 1 359 ? 39.228 -25.317 17.232 1.00 68.58 ? 359 ASP A OD1 1 ATOM 2777 O OD2 . ASP A 1 359 ? 41.156 -26.382 17.227 1.00 70.22 ? 359 ASP A OD2 1 ATOM 2778 N N . LEU A 1 360 ? 39.020 -23.406 14.407 1.00 44.99 ? 360 LEU A N 1 ATOM 2779 C CA . LEU A 1 360 ? 39.536 -22.045 14.175 1.00 44.62 ? 360 LEU A CA 1 ATOM 2780 C C . LEU A 1 360 ? 40.952 -21.896 14.676 1.00 49.13 ? 360 LEU A C 1 ATOM 2781 O O . LEU A 1 360 ? 41.801 -21.396 13.948 1.00 48.34 ? 360 LEU A O 1 ATOM 2782 C CB . LEU A 1 360 ? 38.624 -20.997 14.844 1.00 44.09 ? 360 LEU A CB 1 ATOM 2783 C CG . LEU A 1 360 ? 38.923 -19.539 14.566 1.00 47.51 ? 360 LEU A CG 1 ATOM 2784 C CD1 . LEU A 1 360 ? 38.797 -19.225 13.081 1.00 47.41 ? 360 LEU A CD1 1 ATOM 2785 C CD2 . LEU A 1 360 ? 38.009 -18.637 15.397 1.00 48.78 ? 360 LEU A CD2 1 ATOM 2786 N N . GLU A 1 361 ? 41.206 -22.398 15.896 1.00 46.33 ? 361 GLU A N 1 ATOM 2787 C CA . GLU A 1 361 ? 42.495 -22.381 16.580 1.00 46.31 ? 361 GLU A CA 1 ATOM 2788 C C . GLU A 1 361 ? 43.594 -23.139 15.817 1.00 49.85 ? 361 GLU A C 1 ATOM 2789 O O . GLU A 1 361 ? 44.748 -23.066 16.228 1.00 50.58 ? 361 GLU A O 1 ATOM 2790 C CB . GLU A 1 361 ? 42.355 -22.944 18.013 1.00 47.69 ? 361 GLU A CB 1 ATOM 2791 C CG . GLU A 1 361 ? 41.371 -22.190 18.904 1.00 60.39 ? 361 GLU A CG 1 ATOM 2792 C CD . GLU A 1 361 ? 41.456 -22.511 20.384 1.00 86.41 ? 361 GLU A CD 1 ATOM 2793 O OE1 . GLU A 1 361 ? 42.591 -22.670 20.890 1.00 87.25 ? 361 GLU A OE1 1 ATOM 2794 O OE2 . GLU A 1 361 ? 40.395 -22.562 21.049 1.00 78.83 ? 361 GLU A OE2 1 ATOM 2795 N N . LEU A 1 362 ? 43.251 -23.863 14.729 1.00 44.36 ? 362 LEU A N 1 ATOM 2796 C CA . LEU A 1 362 ? 44.228 -24.633 13.948 1.00 43.43 ? 362 LEU A CA 1 ATOM 2797 C C . LEU A 1 362 ? 44.651 -23.957 12.624 1.00 46.72 ? 362 LEU A C 1 ATOM 2798 O O . LEU A 1 362 ? 45.668 -24.352 12.052 1.00 44.37 ? 362 LEU A O 1 ATOM 2799 C CB . LEU A 1 362 ? 43.750 -26.081 13.710 1.00 43.15 ? 362 LEU A CB 1 ATOM 2800 C CG . LEU A 1 362 ? 43.662 -27.007 14.945 1.00 47.34 ? 362 LEU A CG 1 ATOM 2801 C CD1 . LEU A 1 362 ? 43.096 -28.358 14.565 1.00 47.16 ? 362 LEU A CD1 1 ATOM 2802 C CD2 . LEU A 1 362 ? 45.030 -27.191 15.631 1.00 48.20 ? 362 LEU A CD2 1 ATOM 2803 N N . ILE A 1 363 ? 43.906 -22.919 12.165 1.00 44.90 ? 363 ILE A N 1 ATOM 2804 C CA . ILE A 1 363 ? 44.244 -22.147 10.961 1.00 45.22 ? 363 ILE A CA 1 ATOM 2805 C C . ILE A 1 363 ? 45.393 -21.159 11.266 1.00 50.88 ? 363 ILE A C 1 ATOM 2806 O O . ILE A 1 363 ? 45.256 -20.335 12.171 1.00 48.05 ? 363 ILE A O 1 ATOM 2807 C CB . ILE A 1 363 ? 43.017 -21.424 10.336 1.00 48.12 ? 363 ILE A CB 1 ATOM 2808 C CG1 . ILE A 1 363 ? 41.868 -22.399 10.098 1.00 48.46 ? 363 ILE A CG1 1 ATOM 2809 C CG2 . ILE A 1 363 ? 43.408 -20.685 9.021 1.00 49.09 ? 363 ILE A CG2 1 ATOM 2810 C CD1 . ILE A 1 363 ? 40.586 -21.791 10.137 1.00 55.43 ? 363 ILE A CD1 1 ATOM 2811 N N . THR A 1 364 ? 46.498 -21.230 10.475 1.00 51.77 ? 364 THR A N 1 ATOM 2812 C CA . THR A 1 364 ? 47.681 -20.364 10.581 1.00 53.39 ? 364 THR A CA 1 ATOM 2813 C C . THR A 1 364 ? 47.572 -19.168 9.615 1.00 60.56 ? 364 THR A C 1 ATOM 2814 O O . THR A 1 364 ? 47.897 -19.263 8.432 1.00 60.84 ? 364 THR A O 1 ATOM 2815 C CB . THR A 1 364 ? 48.979 -21.173 10.449 1.00 64.14 ? 364 THR A CB 1 ATOM 2816 O OG1 . THR A 1 364 ? 48.905 -22.304 11.321 1.00 67.60 ? 364 THR A OG1 1 ATOM 2817 C CG2 . THR A 1 364 ? 50.219 -20.349 10.785 1.00 60.54 ? 364 THR A CG2 1 ATOM 2818 N N . SER A 1 365 ? 47.091 -18.048 10.157 1.00 58.81 ? 365 SER A N 1 ATOM 2819 C CA . SER A 1 365 ? 46.834 -16.778 9.484 1.00 58.69 ? 365 SER A CA 1 ATOM 2820 C C . SER A 1 365 ? 47.931 -15.763 9.853 1.00 63.86 ? 365 SER A C 1 ATOM 2821 O O . SER A 1 365 ? 48.010 -15.377 11.026 1.00 64.04 ? 365 SER A O 1 ATOM 2822 C CB . SER A 1 365 ? 45.458 -16.247 9.913 1.00 60.53 ? 365 SER A CB 1 ATOM 2823 O OG . SER A 1 365 ? 45.172 -16.336 11.304 1.00 58.93 ? 365 SER A OG 1 ATOM 2824 N N . CYS A 1 366 ? 48.765 -15.322 8.861 1.00 59.48 ? 366 CYS A N 1 ATOM 2825 C CA . CYS A 1 366 ? 49.857 -14.343 9.046 1.00 58.52 ? 366 CYS A CA 1 ATOM 2826 C C . CYS A 1 366 ? 50.843 -14.809 10.136 1.00 60.68 ? 366 CYS A C 1 ATOM 2827 O O . CYS A 1 366 ? 51.162 -14.032 11.041 1.00 60.08 ? 366 CYS A O 1 ATOM 2828 C CB . CYS A 1 366 ? 49.308 -12.948 9.357 1.00 58.93 ? 366 CYS A CB 1 ATOM 2829 S SG . CYS A 1 366 ? 48.675 -12.039 7.921 1.00 63.15 ? 366 CYS A SG 1 ATOM 2830 N N . SER A 1 367 ? 51.288 -16.093 10.063 1.00 55.66 ? 367 SER A N 1 ATOM 2831 C CA . SER A 1 367 ? 52.183 -16.776 11.019 1.00 54.27 ? 367 SER A CA 1 ATOM 2832 C C . SER A 1 367 ? 51.581 -16.893 12.443 1.00 56.61 ? 367 SER A C 1 ATOM 2833 O O . SER A 1 367 ? 52.205 -17.491 13.327 1.00 56.86 ? 367 SER A O 1 ATOM 2834 C CB . SER A 1 367 ? 53.571 -16.142 11.039 1.00 56.76 ? 367 SER A CB 1 ATOM 2835 O OG . SER A 1 367 ? 54.154 -16.204 9.747 1.00 64.50 ? 367 SER A OG 1 ATOM 2836 N N . SER A 1 368 ? 50.355 -16.355 12.635 1.00 51.03 ? 368 SER A N 1 ATOM 2837 C CA . SER A 1 368 ? 49.565 -16.341 13.871 1.00 50.08 ? 368 SER A CA 1 ATOM 2838 C C . SER A 1 368 ? 48.398 -17.336 13.785 1.00 52.02 ? 368 SER A C 1 ATOM 2839 O O . SER A 1 368 ? 48.182 -17.940 12.733 1.00 51.65 ? 368 SER A O 1 ATOM 2840 C CB . SER A 1 368 ? 48.961 -14.953 14.097 1.00 53.77 ? 368 SER A CB 1 ATOM 2841 O OG . SER A 1 368 ? 49.911 -13.906 14.068 1.00 63.18 ? 368 SER A OG 1 ATOM 2842 N N . ASN A 1 369 ? 47.619 -17.452 14.892 1.00 46.11 ? 369 ASN A N 1 ATOM 2843 C CA . ASN A 1 369 ? 46.421 -18.273 15.057 1.00 44.42 ? 369 ASN A CA 1 ATOM 2844 C C . ASN A 1 369 ? 45.605 -17.814 16.279 1.00 47.90 ? 369 ASN A C 1 ATOM 2845 O O . ASN A 1 369 ? 46.148 -17.179 17.190 1.00 47.75 ? 369 ASN A O 1 ATOM 2846 C CB . ASN A 1 369 ? 46.775 -19.750 15.171 1.00 40.35 ? 369 ASN A CB 1 ATOM 2847 C CG . ASN A 1 369 ? 47.657 -20.079 16.338 1.00 67.04 ? 369 ASN A CG 1 ATOM 2848 O OD1 . ASN A 1 369 ? 48.883 -20.057 16.235 1.00 61.46 ? 369 ASN A OD1 1 ATOM 2849 N ND2 . ASN A 1 369 ? 47.055 -20.350 17.493 1.00 60.94 ? 369 ASN A ND2 1 ATOM 2850 N N . VAL A 1 370 ? 44.306 -18.157 16.299 1.00 43.08 ? 370 VAL A N 1 ATOM 2851 C CA . VAL A 1 370 ? 43.396 -17.875 17.409 1.00 41.99 ? 370 VAL A CA 1 ATOM 2852 C C . VAL A 1 370 ? 43.686 -18.867 18.552 1.00 46.75 ? 370 VAL A C 1 ATOM 2853 O O . VAL A 1 370 ? 44.102 -20.007 18.318 1.00 46.76 ? 370 VAL A O 1 ATOM 2854 C CB . VAL A 1 370 ? 41.908 -17.945 16.983 1.00 45.21 ? 370 VAL A CB 1 ATOM 2855 C CG1 . VAL A 1 370 ? 40.988 -17.514 18.122 1.00 45.01 ? 370 VAL A CG1 1 ATOM 2856 C CG2 . VAL A 1 370 ? 41.642 -17.096 15.743 1.00 44.94 ? 370 VAL A CG2 1 ATOM 2857 N N . SER A 1 371 ? 43.485 -18.415 19.789 1.00 42.71 ? 371 SER A N 1 ATOM 2858 C CA . SER A 1 371 ? 43.637 -19.233 20.984 1.00 41.66 ? 371 SER A CA 1 ATOM 2859 C C . SER A 1 371 ? 42.719 -18.671 22.055 1.00 42.88 ? 371 SER A C 1 ATOM 2860 O O . SER A 1 371 ? 42.200 -17.567 21.904 1.00 39.02 ? 371 SER A O 1 ATOM 2861 C CB . SER A 1 371 ? 45.093 -19.291 21.449 1.00 45.60 ? 371 SER A CB 1 ATOM 2862 O OG . SER A 1 371 ? 45.436 -20.600 21.875 1.00 51.78 ? 371 SER A OG 1 ATOM 2863 N N . VAL A 1 372 ? 42.463 -19.457 23.100 1.00 42.71 ? 372 VAL A N 1 ATOM 2864 C CA . VAL A 1 372 ? 41.555 -19.053 24.158 1.00 43.96 ? 372 VAL A CA 1 ATOM 2865 C C . VAL A 1 372 ? 42.265 -19.091 25.526 1.00 50.61 ? 372 VAL A C 1 ATOM 2866 O O . VAL A 1 372 ? 43.197 -19.879 25.755 1.00 50.28 ? 372 VAL A O 1 ATOM 2867 C CB . VAL A 1 372 ? 40.208 -19.850 24.093 1.00 48.20 ? 372 VAL A CB 1 ATOM 2868 C CG1 . VAL A 1 372 ? 40.314 -21.240 24.705 1.00 48.08 ? 372 VAL A CG1 1 ATOM 2869 C CG2 . VAL A 1 372 ? 39.045 -19.069 24.703 1.00 48.18 ? 372 VAL A CG2 1 ATOM 2870 N N . ALA A 1 373 ? 41.861 -18.150 26.383 1.00 48.49 ? 373 ALA A N 1 ATOM 2871 C CA . ALA A 1 373 ? 42.289 -17.955 27.764 1.00 48.71 ? 373 ALA A CA 1 ATOM 2872 C C . ALA A 1 373 ? 41.056 -17.374 28.486 1.00 54.04 ? 373 ALA A C 1 ATOM 2873 O O . ALA A 1 373 ? 39.963 -17.382 27.906 1.00 53.36 ? 373 ALA A O 1 ATOM 2874 C CB . ALA A 1 373 ? 43.465 -16.990 27.817 1.00 49.19 ? 373 ALA A CB 1 ATOM 2875 N N . HIS A 1 374 ? 41.204 -16.901 29.730 1.00 52.51 ? 374 HIS A N 1 ATOM 2876 C CA . HIS A 1 374 ? 40.079 -16.346 30.487 1.00 53.60 ? 374 HIS A CA 1 ATOM 2877 C C . HIS A 1 374 ? 40.400 -14.984 31.089 1.00 59.44 ? 374 HIS A C 1 ATOM 2878 O O . HIS A 1 374 ? 41.540 -14.749 31.481 1.00 59.35 ? 374 HIS A O 1 ATOM 2879 C CB . HIS A 1 374 ? 39.622 -17.328 31.566 1.00 54.52 ? 374 HIS A CB 1 ATOM 2880 C CG . HIS A 1 374 ? 39.307 -18.674 31.015 1.00 58.03 ? 374 HIS A CG 1 ATOM 2881 N ND1 . HIS A 1 374 ? 40.302 -19.607 30.795 1.00 60.00 ? 374 HIS A ND1 1 ATOM 2882 C CD2 . HIS A 1 374 ? 38.133 -19.172 30.571 1.00 60.16 ? 374 HIS A CD2 1 ATOM 2883 C CE1 . HIS A 1 374 ? 39.699 -20.658 30.266 1.00 59.67 ? 374 HIS A CE1 1 ATOM 2884 N NE2 . HIS A 1 374 ? 38.393 -20.445 30.113 1.00 60.06 ? 374 HIS A NE2 1 ATOM 2885 N N . ASP A 1 375 ? 39.399 -14.096 31.171 1.00 57.18 ? 375 ASP A N 1 ATOM 2886 C CA . ASP A 1 375 ? 39.560 -12.754 31.739 1.00 58.03 ? 375 ASP A CA 1 ATOM 2887 C C . ASP A 1 375 ? 39.505 -12.795 33.279 1.00 62.50 ? 375 ASP A C 1 ATOM 2888 O O . ASP A 1 375 ? 39.613 -13.876 33.855 1.00 61.50 ? 375 ASP A O 1 ATOM 2889 C CB . ASP A 1 375 ? 38.505 -11.774 31.154 1.00 60.20 ? 375 ASP A CB 1 ATOM 2890 C CG . ASP A 1 375 ? 37.040 -12.061 31.460 1.00 71.83 ? 375 ASP A CG 1 ATOM 2891 O OD1 . ASP A 1 375 ? 36.765 -12.937 32.303 1.00 75.01 ? 375 ASP A OD1 1 ATOM 2892 O OD2 . ASP A 1 375 ? 36.169 -11.397 30.862 1.00 76.41 ? 375 ASP A OD2 1 ATOM 2893 N N . ALA A 1 376 ? 39.314 -11.626 33.940 1.00 60.04 ? 376 ALA A N 1 ATOM 2894 C CA . ALA A 1 376 ? 39.192 -11.526 35.404 1.00 59.78 ? 376 ALA A CA 1 ATOM 2895 C C . ALA A 1 376 ? 37.918 -12.259 35.877 1.00 63.74 ? 376 ALA A C 1 ATOM 2896 O O . ALA A 1 376 ? 37.984 -13.046 36.821 1.00 63.79 ? 376 ALA A O 1 ATOM 2897 C CB . ALA A 1 376 ? 39.163 -10.065 35.835 1.00 60.24 ? 376 ALA A CB 1 ATOM 2898 N N . SER A 1 377 ? 36.792 -12.070 35.152 1.00 58.64 ? 377 SER A N 1 ATOM 2899 C CA . SER A 1 377 ? 35.505 -12.697 35.444 1.00 57.39 ? 377 SER A CA 1 ATOM 2900 C C . SER A 1 377 ? 35.436 -14.202 35.113 1.00 57.41 ? 377 SER A C 1 ATOM 2901 O O . SER A 1 377 ? 34.459 -14.862 35.473 1.00 56.57 ? 377 SER A O 1 ATOM 2902 C CB . SER A 1 377 ? 34.380 -11.934 34.754 1.00 62.92 ? 377 SER A CB 1 ATOM 2903 O OG . SER A 1 377 ? 34.398 -12.120 33.348 1.00 76.70 ? 377 SER A OG 1 ATOM 2904 N N . GLY A 1 378 ? 36.468 -14.730 34.461 1.00 52.78 ? 378 GLY A N 1 ATOM 2905 C CA . GLY A 1 378 ? 36.551 -16.143 34.094 1.00 51.98 ? 378 GLY A CA 1 ATOM 2906 C C . GLY A 1 378 ? 35.961 -16.481 32.739 1.00 54.23 ? 378 GLY A C 1 ATOM 2907 O O . GLY A 1 378 ? 35.973 -17.647 32.339 1.00 53.00 ? 378 GLY A O 1 ATOM 2908 N N . LYS A 1 379 ? 35.436 -15.457 32.034 1.00 50.75 ? 379 LYS A N 1 ATOM 2909 C CA . LYS A 1 379 ? 34.834 -15.518 30.699 1.00 51.02 ? 379 LYS A CA 1 ATOM 2910 C C . LYS A 1 379 ? 35.858 -15.971 29.641 1.00 56.29 ? 379 LYS A C 1 ATOM 2911 O O . LYS A 1 379 ? 36.950 -15.405 29.576 1.00 56.73 ? 379 LYS A O 1 ATOM 2912 C CB . LYS A 1 379 ? 34.263 -14.126 30.352 1.00 53.72 ? 379 LYS A CB 1 ATOM 2913 C CG . LYS A 1 379 ? 33.703 -13.931 28.940 1.00 62.25 ? 379 LYS A CG 1 ATOM 2914 C CD . LYS A 1 379 ? 33.204 -12.490 28.737 1.00 66.83 ? 379 LYS A CD 1 ATOM 2915 C CE . LYS A 1 379 ? 34.215 -11.578 28.072 1.00 76.30 ? 379 LYS A CE 1 ATOM 2916 N NZ . LYS A 1 379 ? 33.718 -10.172 27.946 1.00 80.62 ? 379 LYS A NZ 1 ATOM 2917 N N . ARG A 1 380 ? 35.504 -16.992 28.826 1.00 52.46 ? 380 ARG A N 1 ATOM 2918 C CA . ARG A 1 380 ? 36.358 -17.503 27.753 1.00 52.16 ? 380 ARG A CA 1 ATOM 2919 C C . ARG A 1 380 ? 36.569 -16.384 26.731 1.00 56.05 ? 380 ARG A C 1 ATOM 2920 O O . ARG A 1 380 ? 35.592 -15.845 26.192 1.00 55.50 ? 380 ARG A O 1 ATOM 2921 C CB . ARG A 1 380 ? 35.720 -18.726 27.086 1.00 52.84 ? 380 ARG A CB 1 ATOM 2922 C CG . ARG A 1 380 ? 36.380 -20.041 27.481 1.00 65.60 ? 380 ARG A CG 1 ATOM 2923 C CD . ARG A 1 380 ? 35.612 -21.270 27.004 1.00 71.38 ? 380 ARG A CD 1 ATOM 2924 N NE . ARG A 1 380 ? 35.590 -21.403 25.543 1.00 73.13 ? 380 ARG A NE 1 ATOM 2925 C CZ . ARG A 1 380 ? 36.417 -22.166 24.836 1.00 82.85 ? 380 ARG A CZ 1 ATOM 2926 N NH1 . ARG A 1 380 ? 37.356 -22.883 25.443 1.00 73.30 ? 380 ARG A NH1 1 ATOM 2927 N NH2 . ARG A 1 380 ? 36.310 -22.222 23.514 1.00 62.95 ? 380 ARG A NH2 1 ATOM 2928 N N . VAL A 1 381 ? 37.848 -15.999 26.525 1.00 51.88 ? 381 VAL A N 1 ATOM 2929 C CA . VAL A 1 381 ? 38.257 -14.917 25.620 1.00 50.67 ? 381 VAL A CA 1 ATOM 2930 C C . VAL A 1 381 ? 39.206 -15.413 24.502 1.00 54.22 ? 381 VAL A C 1 ATOM 2931 O O . VAL A 1 381 ? 40.254 -16.006 24.791 1.00 54.82 ? 381 VAL A O 1 ATOM 2932 C CB . VAL A 1 381 ? 38.829 -13.692 26.399 1.00 53.23 ? 381 VAL A CB 1 ATOM 2933 C CG1 . VAL A 1 381 ? 39.401 -14.103 27.725 1.00 53.08 ? 381 VAL A CG1 1 ATOM 2934 C CG2 . VAL A 1 381 ? 39.848 -12.904 25.579 1.00 52.54 ? 381 VAL A CG2 1 ATOM 2935 N N . TYR A 1 382 ? 38.832 -15.135 23.229 1.00 48.00 ? 382 TYR A N 1 ATOM 2936 C CA . TYR A 1 382 ? 39.632 -15.449 22.044 1.00 46.03 ? 382 TYR A CA 1 ATOM 2937 C C . TYR A 1 382 ? 40.600 -14.300 21.791 1.00 47.73 ? 382 TYR A C 1 ATOM 2938 O O . TYR A 1 382 ? 40.225 -13.131 21.891 1.00 47.97 ? 382 TYR A O 1 ATOM 2939 C CB . TYR A 1 382 ? 38.743 -15.711 20.800 1.00 46.86 ? 382 TYR A CB 1 ATOM 2940 C CG . TYR A 1 382 ? 37.902 -16.958 20.929 1.00 48.44 ? 382 TYR A CG 1 ATOM 2941 C CD1 . TYR A 1 382 ? 38.410 -18.206 20.578 1.00 49.99 ? 382 TYR A CD1 1 ATOM 2942 C CD2 . TYR A 1 382 ? 36.627 -16.905 21.484 1.00 49.95 ? 382 TYR A CD2 1 ATOM 2943 C CE1 . TYR A 1 382 ? 37.667 -19.370 20.770 1.00 51.65 ? 382 TYR A CE1 1 ATOM 2944 C CE2 . TYR A 1 382 ? 35.883 -18.062 21.704 1.00 51.40 ? 382 TYR A CE2 1 ATOM 2945 C CZ . TYR A 1 382 ? 36.397 -19.293 21.328 1.00 60.45 ? 382 TYR A CZ 1 ATOM 2946 O OH . TYR A 1 382 ? 35.622 -20.417 21.502 1.00 62.41 ? 382 TYR A OH 1 ATOM 2947 N N . TYR A 1 383 ? 41.854 -14.634 21.502 1.00 42.85 ? 383 TYR A N 1 ATOM 2948 C CA . TYR A 1 383 ? 42.931 -13.676 21.219 1.00 41.88 ? 383 TYR A CA 1 ATOM 2949 C C . TYR A 1 383 ? 43.852 -14.287 20.161 1.00 45.18 ? 383 TYR A C 1 ATOM 2950 O O . TYR A 1 383 ? 43.779 -15.496 19.918 1.00 43.78 ? 383 TYR A O 1 ATOM 2951 C CB . TYR A 1 383 ? 43.723 -13.328 22.514 1.00 42.09 ? 383 TYR A CB 1 ATOM 2952 C CG . TYR A 1 383 ? 44.613 -14.455 22.996 1.00 42.99 ? 383 TYR A CG 1 ATOM 2953 C CD1 . TYR A 1 383 ? 44.105 -15.481 23.792 1.00 44.27 ? 383 TYR A CD1 1 ATOM 2954 C CD2 . TYR A 1 383 ? 45.953 -14.524 22.619 1.00 43.53 ? 383 TYR A CD2 1 ATOM 2955 C CE1 . TYR A 1 383 ? 44.906 -16.555 24.185 1.00 43.71 ? 383 TYR A CE1 1 ATOM 2956 C CE2 . TYR A 1 383 ? 46.761 -15.591 23.009 1.00 43.86 ? 383 TYR A CE2 1 ATOM 2957 C CZ . TYR A 1 383 ? 46.234 -16.602 23.791 1.00 49.17 ? 383 TYR A CZ 1 ATOM 2958 O OH . TYR A 1 383 ? 47.034 -17.646 24.169 1.00 50.39 ? 383 TYR A OH 1 ATOM 2959 N N . LEU A 1 384 ? 44.748 -13.464 19.575 1.00 42.48 ? 384 LEU A N 1 ATOM 2960 C CA . LEU A 1 384 ? 45.722 -13.915 18.577 1.00 42.12 ? 384 LEU A CA 1 ATOM 2961 C C . LEU A 1 384 ? 47.109 -14.121 19.173 1.00 44.92 ? 384 LEU A C 1 ATOM 2962 O O . LEU A 1 384 ? 47.640 -13.249 19.872 1.00 44.61 ? 384 LEU A O 1 ATOM 2963 C CB . LEU A 1 384 ? 45.789 -12.975 17.366 1.00 42.01 ? 384 LEU A CB 1 ATOM 2964 C CG . LEU A 1 384 ? 44.807 -13.276 16.260 1.00 46.86 ? 384 LEU A CG 1 ATOM 2965 C CD1 . LEU A 1 384 ? 44.379 -12.023 15.599 1.00 46.90 ? 384 LEU A CD1 1 ATOM 2966 C CD2 . LEU A 1 384 ? 45.400 -14.221 15.222 1.00 51.33 ? 384 LEU A CD2 1 ATOM 2967 N N . THR A 1 385 ? 47.685 -15.283 18.877 1.00 39.74 ? 385 THR A N 1 ATOM 2968 C CA . THR A 1 385 ? 49.013 -15.699 19.319 1.00 39.70 ? 385 THR A CA 1 ATOM 2969 C C . THR A 1 385 ? 49.793 -16.229 18.122 1.00 43.82 ? 385 THR A C 1 ATOM 2970 O O . THR A 1 385 ? 49.262 -16.243 17.022 1.00 44.21 ? 385 THR A O 1 ATOM 2971 C CB . THR A 1 385 ? 48.901 -16.729 20.468 1.00 50.50 ? 385 THR A CB 1 ATOM 2972 O OG1 . THR A 1 385 ? 50.204 -17.034 20.959 1.00 52.27 ? 385 THR A OG1 1 ATOM 2973 C CG2 . THR A 1 385 ? 48.185 -18.012 20.064 1.00 49.65 ? 385 THR A CG2 1 ATOM 2974 N N . ARG A 1 386 ? 51.020 -16.703 18.331 1.00 39.50 ? 386 ARG A N 1 ATOM 2975 C CA . ARG A 1 386 ? 51.850 -17.292 17.281 1.00 39.05 ? 386 ARG A CA 1 ATOM 2976 C C . ARG A 1 386 ? 52.945 -18.113 17.927 1.00 45.11 ? 386 ARG A C 1 ATOM 2977 O O . ARG A 1 386 ? 53.087 -18.079 19.158 1.00 44.85 ? 386 ARG A O 1 ATOM 2978 C CB . ARG A 1 386 ? 52.471 -16.197 16.400 1.00 36.86 ? 386 ARG A CB 1 ATOM 2979 C CG . ARG A 1 386 ? 53.486 -15.325 17.123 1.00 34.51 ? 386 ARG A CG 1 ATOM 2980 C CD . ARG A 1 386 ? 54.358 -14.638 16.139 1.00 37.21 ? 386 ARG A CD 1 ATOM 2981 N NE . ARG A 1 386 ? 55.217 -15.588 15.439 1.00 40.41 ? 386 ARG A NE 1 ATOM 2982 C CZ . ARG A 1 386 ? 55.789 -15.336 14.269 1.00 54.51 ? 386 ARG A CZ 1 ATOM 2983 N NH1 . ARG A 1 386 ? 55.588 -14.174 13.659 1.00 43.42 ? 386 ARG A NH1 1 ATOM 2984 N NH2 . ARG A 1 386 ? 56.568 -16.243 13.697 1.00 41.72 ? 386 ARG A NH2 1 ATOM 2985 N N . ASP A 1 387 ? 53.748 -18.823 17.105 1.00 43.29 ? 387 ASP A N 1 ATOM 2986 C CA . ASP A 1 387 ? 54.886 -19.573 17.631 1.00 43.47 ? 387 ASP A CA 1 ATOM 2987 C C . ASP A 1 387 ? 55.914 -18.547 18.119 1.00 47.82 ? 387 ASP A C 1 ATOM 2988 O O . ASP A 1 387 ? 56.241 -17.620 17.368 1.00 48.04 ? 387 ASP A O 1 ATOM 2989 C CB . ASP A 1 387 ? 55.492 -20.518 16.588 1.00 45.09 ? 387 ASP A CB 1 ATOM 2990 C CG . ASP A 1 387 ? 56.266 -21.647 17.240 1.00 56.21 ? 387 ASP A CG 1 ATOM 2991 O OD1 . ASP A 1 387 ? 57.336 -21.373 17.823 1.00 57.10 ? 387 ASP A OD1 1 ATOM 2992 O OD2 . ASP A 1 387 ? 55.774 -22.796 17.216 1.00 59.93 ? 387 ASP A OD2 1 ATOM 2993 N N . PRO A 1 388 ? 56.360 -18.615 19.390 1.00 44.62 ? 388 PRO A N 1 ATOM 2994 C CA . PRO A 1 388 ? 57.294 -17.581 19.874 1.00 44.62 ? 388 PRO A CA 1 ATOM 2995 C C . PRO A 1 388 ? 58.736 -17.721 19.378 1.00 47.42 ? 388 PRO A C 1 ATOM 2996 O O . PRO A 1 388 ? 59.534 -16.831 19.656 1.00 46.96 ? 388 PRO A O 1 ATOM 2997 C CB . PRO A 1 388 ? 57.176 -17.678 21.400 1.00 46.36 ? 388 PRO A CB 1 ATOM 2998 C CG . PRO A 1 388 ? 56.753 -19.078 21.666 1.00 50.56 ? 388 PRO A CG 1 ATOM 2999 C CD . PRO A 1 388 ? 56.054 -19.612 20.439 1.00 46.09 ? 388 PRO A CD 1 ATOM 3000 N N . THR A 1 389 ? 59.063 -18.793 18.617 1.00 43.35 ? 389 THR A N 1 ATOM 3001 C CA . THR A 1 389 ? 60.417 -19.063 18.120 1.00 42.99 ? 389 THR A CA 1 ATOM 3002 C C . THR A 1 389 ? 61.054 -17.854 17.444 1.00 46.99 ? 389 THR A C 1 ATOM 3003 O O . THR A 1 389 ? 62.059 -17.354 17.965 1.00 47.14 ? 389 THR A O 1 ATOM 3004 C CB . THR A 1 389 ? 60.459 -20.308 17.232 1.00 49.87 ? 389 THR A CB 1 ATOM 3005 O OG1 . THR A 1 389 ? 60.007 -21.431 17.982 1.00 48.77 ? 389 THR A OG1 1 ATOM 3006 C CG2 . THR A 1 389 ? 61.841 -20.594 16.713 1.00 48.16 ? 389 THR A CG2 1 ATOM 3007 N N . THR A 1 390 ? 60.472 -17.372 16.314 1.00 42.39 ? 390 THR A N 1 ATOM 3008 C CA . THR A 1 390 ? 61.031 -16.237 15.573 1.00 42.42 ? 390 THR A CA 1 ATOM 3009 C C . THR A 1 390 ? 61.042 -14.967 16.453 1.00 46.23 ? 390 THR A C 1 ATOM 3010 O O . THR A 1 390 ? 62.143 -14.421 16.617 1.00 45.45 ? 390 THR A O 1 ATOM 3011 C CB . THR A 1 390 ? 60.390 -16.074 14.188 1.00 48.42 ? 390 THR A CB 1 ATOM 3012 O OG1 . THR A 1 390 ? 60.905 -17.114 13.352 1.00 47.20 ? 390 THR A OG1 1 ATOM 3013 C CG2 . THR A 1 390 ? 60.702 -14.724 13.546 1.00 43.21 ? 390 THR A CG2 1 ATOM 3014 N N . PRO A 1 391 ? 59.916 -14.519 17.094 1.00 41.95 ? 391 PRO A N 1 ATOM 3015 C CA . PRO A 1 391 ? 60.002 -13.336 17.967 1.00 41.22 ? 391 PRO A CA 1 ATOM 3016 C C . PRO A 1 391 ? 61.095 -13.428 19.031 1.00 44.79 ? 391 PRO A C 1 ATOM 3017 O O . PRO A 1 391 ? 61.814 -12.442 19.215 1.00 44.90 ? 391 PRO A O 1 ATOM 3018 C CB . PRO A 1 391 ? 58.604 -13.248 18.581 1.00 42.32 ? 391 PRO A CB 1 ATOM 3019 C CG . PRO A 1 391 ? 57.736 -13.831 17.570 1.00 46.52 ? 391 PRO A CG 1 ATOM 3020 C CD . PRO A 1 391 ? 58.522 -15.003 17.038 1.00 42.80 ? 391 PRO A CD 1 ATOM 3021 N N . LEU A 1 392 ? 61.266 -14.611 19.671 1.00 40.62 ? 392 LEU A N 1 ATOM 3022 C CA . LEU A 1 392 ? 62.276 -14.792 20.721 1.00 40.93 ? 392 LEU A CA 1 ATOM 3023 C C . LEU A 1 392 ? 63.702 -14.776 20.194 1.00 45.47 ? 392 LEU A C 1 ATOM 3024 O O . LEU A 1 392 ? 64.585 -14.265 20.876 1.00 45.47 ? 392 LEU A O 1 ATOM 3025 C CB . LEU A 1 392 ? 62.016 -16.041 21.586 1.00 41.03 ? 392 LEU A CB 1 ATOM 3026 C CG . LEU A 1 392 ? 60.775 -16.017 22.513 1.00 44.39 ? 392 LEU A CG 1 ATOM 3027 C CD1 . LEU A 1 392 ? 60.609 -17.355 23.244 1.00 44.05 ? 392 LEU A CD1 1 ATOM 3028 C CD2 . LEU A 1 392 ? 60.801 -14.837 23.470 1.00 43.30 ? 392 LEU A CD2 1 ATOM 3029 N N . ALA A 1 393 ? 63.924 -15.309 18.979 1.00 42.19 ? 393 ALA A N 1 ATOM 3030 C CA . ALA A 1 393 ? 65.223 -15.310 18.309 1.00 41.43 ? 393 ALA A CA 1 ATOM 3031 C C . ALA A 1 393 ? 65.657 -13.869 17.968 1.00 46.38 ? 393 ALA A C 1 ATOM 3032 O O . ALA A 1 393 ? 66.826 -13.532 18.125 1.00 46.13 ? 393 ALA A O 1 ATOM 3033 C CB . ALA A 1 393 ? 65.145 -16.149 17.044 1.00 41.93 ? 393 ALA A CB 1 ATOM 3034 N N . ARG A 1 394 ? 64.705 -13.021 17.525 1.00 44.07 ? 394 ARG A N 1 ATOM 3035 C CA . ARG A 1 394 ? 64.953 -11.618 17.164 1.00 44.07 ? 394 ARG A CA 1 ATOM 3036 C C . ARG A 1 394 ? 65.157 -10.780 18.409 1.00 47.82 ? 394 ARG A C 1 ATOM 3037 O O . ARG A 1 394 ? 65.975 -9.854 18.404 1.00 47.55 ? 394 ARG A O 1 ATOM 3038 C CB . ARG A 1 394 ? 63.815 -11.059 16.293 1.00 45.03 ? 394 ARG A CB 1 ATOM 3039 C CG . ARG A 1 394 ? 63.681 -11.815 14.981 1.00 56.70 ? 394 ARG A CG 1 ATOM 3040 C CD . ARG A 1 394 ? 62.792 -11.152 13.965 1.00 62.65 ? 394 ARG A CD 1 ATOM 3041 N NE . ARG A 1 394 ? 62.681 -11.994 12.774 1.00 64.40 ? 394 ARG A NE 1 ATOM 3042 C CZ . ARG A 1 394 ? 61.823 -11.790 11.779 1.00 66.35 ? 394 ARG A CZ 1 ATOM 3043 N NH1 . ARG A 1 394 ? 60.981 -10.764 11.819 1.00 53.11 ? 394 ARG A NH1 1 ATOM 3044 N NH2 . ARG A 1 394 ? 61.785 -12.623 10.747 1.00 37.20 ? 394 ARG A NH2 1 ATOM 3045 N N . ALA A 1 395 ? 64.434 -11.134 19.489 1.00 44.28 ? 395 ALA A N 1 ATOM 3046 C CA . ALA A 1 395 ? 64.535 -10.494 20.803 1.00 44.03 ? 395 ALA A CA 1 ATOM 3047 C C . ALA A 1 395 ? 65.964 -10.659 21.309 1.00 46.80 ? 395 ALA A C 1 ATOM 3048 O O . ALA A 1 395 ? 66.520 -9.706 21.854 1.00 45.61 ? 395 ALA A O 1 ATOM 3049 C CB . ALA A 1 395 ? 63.575 -11.155 21.774 1.00 44.70 ? 395 ALA A CB 1 ATOM 3050 N N . ALA A 1 396 ? 66.565 -11.857 21.064 1.00 42.21 ? 396 ALA A N 1 ATOM 3051 C CA . ALA A 1 396 ? 67.938 -12.193 21.407 1.00 41.79 ? 396 ALA A CA 1 ATOM 3052 C C . ALA A 1 396 ? 68.907 -11.312 20.620 1.00 46.29 ? 396 ALA A C 1 ATOM 3053 O O . ALA A 1 396 ? 69.904 -10.865 21.197 1.00 47.62 ? 396 ALA A O 1 ATOM 3054 C CB . ALA A 1 396 ? 68.210 -13.661 21.134 1.00 42.46 ? 396 ALA A CB 1 ATOM 3055 N N . TRP A 1 397 ? 68.596 -11.006 19.334 1.00 40.37 ? 397 TRP A N 1 ATOM 3056 C CA . TRP A 1 397 ? 69.448 -10.120 18.535 1.00 39.26 ? 397 TRP A CA 1 ATOM 3057 C C . TRP A 1 397 ? 69.402 -8.682 19.079 1.00 41.12 ? 397 TRP A C 1 ATOM 3058 O O . TRP A 1 397 ? 70.438 -8.004 19.151 1.00 40.01 ? 397 TRP A O 1 ATOM 3059 C CB . TRP A 1 397 ? 69.078 -10.147 17.037 1.00 37.69 ? 397 TRP A CB 1 ATOM 3060 C CG . TRP A 1 397 ? 70.162 -9.598 16.155 1.00 38.14 ? 397 TRP A CG 1 ATOM 3061 C CD1 . TRP A 1 397 ? 70.476 -8.284 15.958 1.00 40.99 ? 397 TRP A CD1 1 ATOM 3062 C CD2 . TRP A 1 397 ? 71.123 -10.355 15.413 1.00 37.95 ? 397 TRP A CD2 1 ATOM 3063 N NE1 . TRP A 1 397 ? 71.579 -8.174 15.144 1.00 40.39 ? 397 TRP A NE1 1 ATOM 3064 C CE2 . TRP A 1 397 ? 71.999 -9.431 14.794 1.00 41.73 ? 397 TRP A CE2 1 ATOM 3065 C CE3 . TRP A 1 397 ? 71.343 -11.732 15.222 1.00 39.02 ? 397 TRP A CE3 1 ATOM 3066 C CZ2 . TRP A 1 397 ? 73.064 -9.835 13.985 1.00 40.67 ? 397 TRP A CZ2 1 ATOM 3067 C CZ3 . TRP A 1 397 ? 72.405 -12.129 14.426 1.00 40.26 ? 397 TRP A CZ3 1 ATOM 3068 C CH2 . TRP A 1 397 ? 73.245 -11.185 13.810 1.00 40.81 ? 397 TRP A CH2 1 ATOM 3069 N N . GLU A 1 398 ? 68.202 -8.245 19.487 1.00 36.17 ? 398 GLU A N 1 ATOM 3070 C CA . GLU A 1 398 ? 67.943 -6.907 20.015 1.00 34.93 ? 398 GLU A CA 1 ATOM 3071 C C . GLU A 1 398 ? 68.365 -6.741 21.484 1.00 37.13 ? 398 GLU A C 1 ATOM 3072 O O . GLU A 1 398 ? 68.145 -5.672 22.065 1.00 37.00 ? 398 GLU A O 1 ATOM 3073 C CB . GLU A 1 398 ? 66.472 -6.522 19.788 1.00 36.27 ? 398 GLU A CB 1 ATOM 3074 C CG . GLU A 1 398 ? 66.171 -6.197 18.335 1.00 46.60 ? 398 GLU A CG 1 ATOM 3075 C CD . GLU A 1 398 ? 64.741 -6.391 17.875 1.00 60.87 ? 398 GLU A CD 1 ATOM 3076 O OE1 . GLU A 1 398 ? 63.935 -6.960 18.643 1.00 37.78 ? 398 GLU A OE1 1 ATOM 3077 O OE2 . GLU A 1 398 ? 64.430 -5.983 16.733 1.00 55.75 ? 398 GLU A OE2 1 ATOM 3078 N N . THR A 1 399 ? 68.977 -7.785 22.078 1.00 32.19 ? 399 THR A N 1 ATOM 3079 C CA . THR A 1 399 ? 69.487 -7.747 23.449 1.00 32.01 ? 399 THR A CA 1 ATOM 3080 C C . THR A 1 399 ? 70.928 -7.217 23.416 1.00 36.30 ? 399 THR A C 1 ATOM 3081 O O . THR A 1 399 ? 71.377 -6.594 24.380 1.00 35.20 ? 399 THR A O 1 ATOM 3082 C CB . THR A 1 399 ? 69.422 -9.162 24.094 1.00 40.51 ? 399 THR A CB 1 ATOM 3083 O OG1 . THR A 1 399 ? 68.122 -9.730 23.905 1.00 38.68 ? 399 THR A OG1 1 ATOM 3084 C CG2 . THR A 1 399 ? 69.746 -9.151 25.580 1.00 35.59 ? 399 THR A CG2 1 ATOM 3085 N N . ALA A 1 400 ? 71.648 -7.479 22.306 1.00 33.78 ? 400 ALA A N 1 ATOM 3086 C CA . ALA A 1 400 ? 73.041 -7.098 22.122 1.00 34.37 ? 400 ALA A CA 1 ATOM 3087 C C . ALA A 1 400 ? 73.285 -6.075 21.003 1.00 41.41 ? 400 ALA A C 1 ATOM 3088 O O . ALA A 1 400 ? 74.383 -5.517 20.918 1.00 39.64 ? 400 ALA A O 1 ATOM 3089 C CB . ALA A 1 400 ? 73.878 -8.342 21.880 1.00 34.96 ? 400 ALA A CB 1 ATOM 3090 N N . ARG A 1 401 ? 72.285 -5.860 20.118 1.00 41.47 ? 401 ARG A N 1 ATOM 3091 C CA . ARG A 1 401 ? 72.402 -4.954 18.973 1.00 41.97 ? 401 ARG A CA 1 ATOM 3092 C C . ARG A 1 401 ? 71.205 -4.055 18.845 1.00 50.38 ? 401 ARG A C 1 ATOM 3093 O O . ARG A 1 401 ? 70.071 -4.512 18.966 1.00 48.56 ? 401 ARG A O 1 ATOM 3094 C CB . ARG A 1 401 ? 72.585 -5.729 17.648 1.00 39.10 ? 401 ARG A CB 1 ATOM 3095 C CG . ARG A 1 401 ? 73.863 -6.524 17.527 1.00 46.23 ? 401 ARG A CG 1 ATOM 3096 C CD . ARG A 1 401 ? 75.063 -5.727 17.062 1.00 59.85 ? 401 ARG A CD 1 ATOM 3097 N NE . ARG A 1 401 ? 76.257 -6.578 17.012 1.00 73.65 ? 401 ARG A NE 1 ATOM 3098 C CZ . ARG A 1 401 ? 77.340 -6.423 17.770 1.00 91.78 ? 401 ARG A CZ 1 ATOM 3099 N NH1 . ARG A 1 401 ? 77.416 -5.421 18.639 1.00 82.40 ? 401 ARG A NH1 1 ATOM 3100 N NH2 . ARG A 1 401 ? 78.362 -7.258 17.651 1.00 77.98 ? 401 ARG A NH2 1 ATOM 3101 N N . HIS A 1 402 ? 71.464 -2.773 18.544 1.00 53.57 ? 402 HIS A N 1 ATOM 3102 C CA . HIS A 1 402 ? 70.427 -1.765 18.297 1.00 56.01 ? 402 HIS A CA 1 ATOM 3103 C C . HIS A 1 402 ? 70.036 -1.835 16.823 1.00 61.63 ? 402 HIS A C 1 ATOM 3104 O O . HIS A 1 402 ? 70.882 -1.629 15.950 1.00 61.57 ? 402 HIS A O 1 ATOM 3105 C CB . HIS A 1 402 ? 70.916 -0.349 18.653 1.00 57.51 ? 402 HIS A CB 1 ATOM 3106 C CG . HIS A 1 402 ? 70.984 -0.093 20.120 1.00 61.50 ? 402 HIS A CG 1 ATOM 3107 N ND1 . HIS A 1 402 ? 72.113 -0.404 20.853 1.00 63.63 ? 402 HIS A ND1 1 ATOM 3108 C CD2 . HIS A 1 402 ? 70.051 0.427 20.948 1.00 63.98 ? 402 HIS A CD2 1 ATOM 3109 C CE1 . HIS A 1 402 ? 71.838 -0.052 22.100 1.00 63.44 ? 402 HIS A CE1 1 ATOM 3110 N NE2 . HIS A 1 402 ? 70.608 0.449 22.209 1.00 63.83 ? 402 HIS A NE2 1 ATOM 3111 N N . THR A 1 403 ? 68.771 -2.177 16.553 1.00 59.30 ? 403 THR A N 1 ATOM 3112 C CA . THR A 1 403 ? 68.230 -2.288 15.196 1.00 59.54 ? 403 THR A CA 1 ATOM 3113 C C . THR A 1 403 ? 67.326 -1.080 14.891 1.00 63.19 ? 403 THR A C 1 ATOM 3114 O O . THR A 1 403 ? 66.835 -0.448 15.833 1.00 61.51 ? 403 THR A O 1 ATOM 3115 C CB . THR A 1 403 ? 67.504 -3.632 15.001 1.00 72.21 ? 403 THR A CB 1 ATOM 3116 O OG1 . THR A 1 403 ? 66.433 -3.745 15.940 1.00 75.27 ? 403 THR A OG1 1 ATOM 3117 C CG2 . THR A 1 403 ? 68.441 -4.828 15.104 1.00 71.63 ? 403 THR A CG2 1 ATOM 3118 N N . PRO A 1 404 ? 67.083 -0.720 13.602 1.00 61.35 ? 404 PRO A N 1 ATOM 3119 C CA . PRO A 1 404 ? 66.202 0.431 13.339 1.00 61.41 ? 404 PRO A CA 1 ATOM 3120 C C . PRO A 1 404 ? 64.738 0.081 13.608 1.00 65.73 ? 404 PRO A C 1 ATOM 3121 O O . PRO A 1 404 ? 63.921 0.976 13.829 1.00 66.29 ? 404 PRO A O 1 ATOM 3122 C CB . PRO A 1 404 ? 66.476 0.762 11.872 1.00 63.15 ? 404 PRO A CB 1 ATOM 3123 C CG . PRO A 1 404 ? 66.923 -0.519 11.264 1.00 67.67 ? 404 PRO A CG 1 ATOM 3124 C CD . PRO A 1 404 ? 67.572 -1.331 12.342 1.00 63.17 ? 404 PRO A CD 1 ATOM 3125 N N . VAL A 1 405 ? 64.426 -1.239 13.617 1.00 60.68 ? 405 VAL A N 1 ATOM 3126 C CA . VAL A 1 405 ? 63.105 -1.808 13.871 1.00 59.51 ? 405 VAL A CA 1 ATOM 3127 C C . VAL A 1 405 ? 63.156 -2.657 15.140 1.00 61.85 ? 405 VAL A C 1 ATOM 3128 O O . VAL A 1 405 ? 63.844 -3.676 15.169 1.00 63.00 ? 405 VAL A O 1 ATOM 3129 C CB . VAL A 1 405 ? 62.598 -2.595 12.649 1.00 63.46 ? 405 VAL A CB 1 ATOM 3130 C CG1 . VAL A 1 405 ? 61.266 -3.238 12.948 1.00 63.31 ? 405 VAL A CG1 1 ATOM 3131 C CG2 . VAL A 1 405 ? 62.485 -1.669 11.446 1.00 63.53 ? 405 VAL A CG2 1 ATOM 3132 N N . ASN A 1 406 ? 62.450 -2.235 16.191 1.00 54.80 ? 406 ASN A N 1 ATOM 3133 C CA . ASN A 1 406 ? 62.469 -3.006 17.423 1.00 52.72 ? 406 ASN A CA 1 ATOM 3134 C C . ASN A 1 406 ? 61.342 -4.011 17.397 1.00 53.08 ? 406 ASN A C 1 ATOM 3135 O O . ASN A 1 406 ? 60.204 -3.689 17.737 1.00 51.81 ? 406 ASN A O 1 ATOM 3136 C CB . ASN A 1 406 ? 62.471 -2.108 18.652 1.00 51.44 ? 406 ASN A CB 1 ATOM 3137 C CG . ASN A 1 406 ? 63.686 -1.219 18.689 1.00 71.97 ? 406 ASN A CG 1 ATOM 3138 O OD1 . ASN A 1 406 ? 64.770 -1.626 19.115 1.00 68.96 ? 406 ASN A OD1 1 ATOM 3139 N ND2 . ASN A 1 406 ? 63.551 -0.007 18.168 1.00 61.59 ? 406 ASN A ND2 1 ATOM 3140 N N . SER A 1 407 ? 61.667 -5.234 16.925 1.00 47.60 ? 407 SER A N 1 ATOM 3141 C CA . SER A 1 407 ? 60.724 -6.344 16.786 1.00 45.82 ? 407 SER A CA 1 ATOM 3142 C C . SER A 1 407 ? 60.074 -6.699 18.111 1.00 48.82 ? 407 SER A C 1 ATOM 3143 O O . SER A 1 407 ? 58.868 -6.910 18.137 1.00 48.27 ? 407 SER A O 1 ATOM 3144 C CB . SER A 1 407 ? 61.393 -7.558 16.157 1.00 47.22 ? 407 SER A CB 1 ATOM 3145 O OG . SER A 1 407 ? 62.162 -8.287 17.094 1.00 55.37 ? 407 SER A OG 1 ATOM 3146 N N . TRP A 1 408 ? 60.860 -6.701 19.219 1.00 44.07 ? 408 TRP A N 1 ATOM 3147 C CA . TRP A 1 408 ? 60.372 -6.971 20.574 1.00 42.47 ? 408 TRP A CA 1 ATOM 3148 C C . TRP A 1 408 ? 59.297 -5.957 20.974 1.00 46.32 ? 408 TRP A C 1 ATOM 3149 O O . TRP A 1 408 ? 58.454 -6.268 21.810 1.00 45.83 ? 408 TRP A O 1 ATOM 3150 C CB . TRP A 1 408 ? 61.525 -6.944 21.597 1.00 40.18 ? 408 TRP A CB 1 ATOM 3151 C CG . TRP A 1 408 ? 62.214 -5.611 21.738 1.00 40.10 ? 408 TRP A CG 1 ATOM 3152 C CD1 . TRP A 1 408 ? 63.307 -5.179 21.049 1.00 42.72 ? 408 TRP A CD1 1 ATOM 3153 C CD2 . TRP A 1 408 ? 61.822 -4.524 22.590 1.00 39.54 ? 408 TRP A CD2 1 ATOM 3154 N NE1 . TRP A 1 408 ? 63.615 -3.888 21.407 1.00 41.75 ? 408 TRP A NE1 1 ATOM 3155 C CE2 . TRP A 1 408 ? 62.715 -3.458 22.346 1.00 42.92 ? 408 TRP A CE2 1 ATOM 3156 C CE3 . TRP A 1 408 ? 60.762 -4.323 23.493 1.00 40.43 ? 408 TRP A CE3 1 ATOM 3157 C CZ2 . TRP A 1 408 ? 62.609 -2.231 23.003 1.00 41.81 ? 408 TRP A CZ2 1 ATOM 3158 C CZ3 . TRP A 1 408 ? 60.662 -3.107 24.147 1.00 41.49 ? 408 TRP A CZ3 1 ATOM 3159 C CH2 . TRP A 1 408 ? 61.581 -2.080 23.905 1.00 41.94 ? 408 TRP A CH2 1 ATOM 3160 N N . LEU A 1 409 ? 59.361 -4.724 20.423 1.00 42.18 ? 409 LEU A N 1 ATOM 3161 C CA . LEU A 1 409 ? 58.380 -3.693 20.759 1.00 41.49 ? 409 LEU A CA 1 ATOM 3162 C C . LEU A 1 409 ? 57.091 -3.926 19.980 1.00 43.73 ? 409 LEU A C 1 ATOM 3163 O O . LEU A 1 409 ? 56.019 -3.815 20.555 1.00 44.38 ? 409 LEU A O 1 ATOM 3164 C CB . LEU A 1 409 ? 58.958 -2.270 20.573 1.00 41.44 ? 409 LEU A CB 1 ATOM 3165 C CG . LEU A 1 409 ? 58.070 -1.065 20.939 1.00 45.76 ? 409 LEU A CG 1 ATOM 3166 C CD1 . LEU A 1 409 ? 57.472 -1.188 22.333 1.00 45.39 ? 409 LEU A CD1 1 ATOM 3167 C CD2 . LEU A 1 409 ? 58.837 0.224 20.805 1.00 47.44 ? 409 LEU A CD2 1 ATOM 3168 N N . GLY A 1 410 ? 57.211 -4.306 18.712 1.00 37.91 ? 410 GLY A N 1 ATOM 3169 C CA . GLY A 1 410 ? 56.073 -4.636 17.867 1.00 36.98 ? 410 GLY A CA 1 ATOM 3170 C C . GLY A 1 410 ? 55.385 -5.901 18.336 1.00 39.56 ? 410 GLY A C 1 ATOM 3171 O O . GLY A 1 410 ? 54.156 -5.981 18.307 1.00 39.31 ? 410 GLY A O 1 ATOM 3172 N N . ASN A 1 411 ? 56.175 -6.885 18.802 1.00 35.24 ? 411 ASN A N 1 ATOM 3173 C CA . ASN A 1 411 ? 55.671 -8.158 19.305 1.00 35.41 ? 411 ASN A CA 1 ATOM 3174 C C . ASN A 1 411 ? 54.902 -7.984 20.602 1.00 40.90 ? 411 ASN A C 1 ATOM 3175 O O . ASN A 1 411 ? 53.907 -8.677 20.799 1.00 40.33 ? 411 ASN A O 1 ATOM 3176 C CB . ASN A 1 411 ? 56.781 -9.205 19.429 1.00 36.46 ? 411 ASN A CB 1 ATOM 3177 C CG . ASN A 1 411 ? 57.235 -9.792 18.107 1.00 61.80 ? 411 ASN A CG 1 ATOM 3178 O OD1 . ASN A 1 411 ? 56.437 -10.151 17.230 1.00 59.93 ? 411 ASN A OD1 1 ATOM 3179 N ND2 . ASN A 1 411 ? 58.536 -9.927 17.942 1.00 54.26 ? 411 ASN A ND2 1 ATOM 3180 N N . ILE A 1 412 ? 55.347 -7.045 21.476 1.00 38.75 ? 412 ILE A N 1 ATOM 3181 C CA . ILE A 1 412 ? 54.683 -6.675 22.730 1.00 38.40 ? 412 ILE A CA 1 ATOM 3182 C C . ILE A 1 412 ? 53.336 -6.028 22.369 1.00 41.52 ? 412 ILE A C 1 ATOM 3183 O O . ILE A 1 412 ? 52.333 -6.337 22.993 1.00 41.40 ? 412 ILE A O 1 ATOM 3184 C CB . ILE A 1 412 ? 55.582 -5.730 23.587 1.00 42.09 ? 412 ILE A CB 1 ATOM 3185 C CG1 . ILE A 1 412 ? 56.553 -6.532 24.469 1.00 42.82 ? 412 ILE A CG1 1 ATOM 3186 C CG2 . ILE A 1 412 ? 54.746 -4.776 24.461 1.00 43.72 ? 412 ILE A CG2 1 ATOM 3187 C CD1 . ILE A 1 412 ? 57.747 -5.728 25.044 1.00 49.15 ? 412 ILE A CD1 1 ATOM 3188 N N . ILE A 1 413 ? 53.321 -5.147 21.357 1.00 37.86 ? 413 ILE A N 1 ATOM 3189 C CA . ILE A 1 413 ? 52.134 -4.431 20.891 1.00 37.61 ? 413 ILE A CA 1 ATOM 3190 C C . ILE A 1 413 ? 51.092 -5.381 20.244 1.00 41.40 ? 413 ILE A C 1 ATOM 3191 O O . ILE A 1 413 ? 49.947 -5.436 20.676 1.00 40.92 ? 413 ILE A O 1 ATOM 3192 C CB . ILE A 1 413 ? 52.555 -3.249 19.946 1.00 40.39 ? 413 ILE A CB 1 ATOM 3193 C CG1 . ILE A 1 413 ? 53.281 -2.136 20.729 1.00 39.90 ? 413 ILE A CG1 1 ATOM 3194 C CG2 . ILE A 1 413 ? 51.348 -2.676 19.166 1.00 40.81 ? 413 ILE A CG2 1 ATOM 3195 C CD1 . ILE A 1 413 ? 54.235 -1.304 19.919 1.00 40.47 ? 413 ILE A CD1 1 ATOM 3196 N N . MET A 1 414 ? 51.501 -6.113 19.218 1.00 37.89 ? 414 MET A N 1 ATOM 3197 C CA . MET A 1 414 ? 50.619 -6.977 18.446 1.00 37.19 ? 414 MET A CA 1 ATOM 3198 C C . MET A 1 414 ? 50.198 -8.257 19.178 1.00 40.75 ? 414 MET A C 1 ATOM 3199 O O . MET A 1 414 ? 49.110 -8.775 18.905 1.00 40.55 ? 414 MET A O 1 ATOM 3200 C CB . MET A 1 414 ? 51.262 -7.282 17.077 1.00 38.85 ? 414 MET A CB 1 ATOM 3201 C CG . MET A 1 414 ? 51.638 -6.024 16.303 1.00 41.62 ? 414 MET A CG 1 ATOM 3202 S SD . MET A 1 414 ? 50.300 -4.809 16.162 1.00 45.43 ? 414 MET A SD 1 ATOM 3203 C CE . MET A 1 414 ? 49.519 -5.383 14.656 1.00 42.37 ? 414 MET A CE 1 ATOM 3204 N N . TYR A 1 415 ? 51.039 -8.743 20.118 1.00 35.82 ? 415 TYR A N 1 ATOM 3205 C CA . TYR A 1 415 ? 50.783 -9.969 20.869 1.00 34.91 ? 415 TYR A CA 1 ATOM 3206 C C . TYR A 1 415 ? 50.740 -9.752 22.370 1.00 37.66 ? 415 TYR A C 1 ATOM 3207 O O . TYR A 1 415 ? 51.079 -10.658 23.135 1.00 37.73 ? 415 TYR A O 1 ATOM 3208 C CB . TYR A 1 415 ? 51.789 -11.072 20.492 1.00 36.25 ? 415 TYR A CB 1 ATOM 3209 C CG . TYR A 1 415 ? 51.794 -11.421 19.024 1.00 38.28 ? 415 TYR A CG 1 ATOM 3210 C CD1 . TYR A 1 415 ? 50.798 -12.220 18.475 1.00 39.59 ? 415 TYR A CD1 1 ATOM 3211 C CD2 . TYR A 1 415 ? 52.790 -10.943 18.179 1.00 39.87 ? 415 TYR A CD2 1 ATOM 3212 C CE1 . TYR A 1 415 ? 50.783 -12.522 17.114 1.00 40.18 ? 415 TYR A CE1 1 ATOM 3213 C CE2 . TYR A 1 415 ? 52.803 -11.260 16.823 1.00 41.13 ? 415 TYR A CE2 1 ATOM 3214 C CZ . TYR A 1 415 ? 51.789 -12.039 16.291 1.00 48.30 ? 415 TYR A CZ 1 ATOM 3215 O OH . TYR A 1 415 ? 51.811 -12.340 14.950 1.00 49.35 ? 415 TYR A OH 1 ATOM 3216 N N . ALA A 1 416 ? 50.272 -8.572 22.796 1.00 33.45 ? 416 ALA A N 1 ATOM 3217 C CA . ALA A 1 416 ? 50.129 -8.214 24.206 1.00 32.90 ? 416 ALA A CA 1 ATOM 3218 C C . ALA A 1 416 ? 49.334 -9.213 25.052 1.00 39.67 ? 416 ALA A C 1 ATOM 3219 O O . ALA A 1 416 ? 49.780 -9.459 26.166 1.00 40.00 ? 416 ALA A O 1 ATOM 3220 C CB . ALA A 1 416 ? 49.525 -6.841 24.334 1.00 33.19 ? 416 ALA A CB 1 ATOM 3221 N N . PRO A 1 417 ? 48.206 -9.833 24.615 1.00 38.16 ? 417 PRO A N 1 ATOM 3222 C CA . PRO A 1 417 ? 47.503 -10.748 25.533 1.00 38.98 ? 417 PRO A CA 1 ATOM 3223 C C . PRO A 1 417 ? 48.052 -12.177 25.589 1.00 42.96 ? 417 PRO A C 1 ATOM 3224 O O . PRO A 1 417 ? 47.479 -13.024 26.288 1.00 42.39 ? 417 PRO A O 1 ATOM 3225 C CB . PRO A 1 417 ? 46.052 -10.696 25.046 1.00 41.15 ? 417 PRO A CB 1 ATOM 3226 C CG . PRO A 1 417 ? 46.150 -10.363 23.592 1.00 45.69 ? 417 PRO A CG 1 ATOM 3227 C CD . PRO A 1 417 ? 47.477 -9.705 23.332 1.00 40.56 ? 417 PRO A CD 1 ATOM 3228 N N . THR A 1 418 ? 49.161 -12.447 24.871 1.00 38.99 ? 418 THR A N 1 ATOM 3229 C CA . THR A 1 418 ? 49.769 -13.776 24.840 1.00 37.90 ? 418 THR A CA 1 ATOM 3230 C C . THR A 1 418 ? 50.577 -14.026 26.087 1.00 42.89 ? 418 THR A C 1 ATOM 3231 O O . THR A 1 418 ? 51.061 -13.086 26.714 1.00 42.69 ? 418 THR A O 1 ATOM 3232 C CB . THR A 1 418 ? 50.598 -14.023 23.568 1.00 37.27 ? 418 THR A CB 1 ATOM 3233 O OG1 . THR A 1 418 ? 51.806 -13.267 23.617 1.00 38.94 ? 418 THR A OG1 1 ATOM 3234 C CG2 . THR A 1 418 ? 49.840 -13.726 22.302 1.00 30.15 ? 418 THR A CG2 1 ATOM 3235 N N . LEU A 1 419 ? 50.730 -15.305 26.430 1.00 40.25 ? 419 LEU A N 1 ATOM 3236 C CA . LEU A 1 419 ? 51.481 -15.817 27.564 1.00 39.76 ? 419 LEU A CA 1 ATOM 3237 C C . LEU A 1 419 ? 52.960 -15.356 27.438 1.00 42.31 ? 419 LEU A C 1 ATOM 3238 O O . LEU A 1 419 ? 53.446 -14.635 28.310 1.00 41.06 ? 419 LEU A O 1 ATOM 3239 C CB . LEU A 1 419 ? 51.325 -17.358 27.536 1.00 40.14 ? 419 LEU A CB 1 ATOM 3240 C CG . LEU A 1 419 ? 52.136 -18.198 28.514 1.00 46.33 ? 419 LEU A CG 1 ATOM 3241 C CD1 . LEU A 1 419 ? 51.368 -18.421 29.800 1.00 47.57 ? 419 LEU A CD1 1 ATOM 3242 C CD2 . LEU A 1 419 ? 52.492 -19.538 27.900 1.00 48.01 ? 419 LEU A CD2 1 ATOM 3243 N N . TRP A 1 420 ? 53.611 -15.684 26.299 1.00 38.41 ? 420 TRP A N 1 ATOM 3244 C CA . TRP A 1 420 ? 55.015 -15.412 25.964 1.00 37.89 ? 420 TRP A CA 1 ATOM 3245 C C . TRP A 1 420 ? 55.421 -13.918 25.888 1.00 39.76 ? 420 TRP A C 1 ATOM 3246 O O . TRP A 1 420 ? 56.494 -13.572 26.395 1.00 39.45 ? 420 TRP A O 1 ATOM 3247 C CB . TRP A 1 420 ? 55.402 -16.127 24.655 1.00 37.18 ? 420 TRP A CB 1 ATOM 3248 C CG . TRP A 1 420 ? 54.521 -15.816 23.474 1.00 38.52 ? 420 TRP A CG 1 ATOM 3249 C CD1 . TRP A 1 420 ? 53.341 -16.420 23.146 1.00 41.47 ? 420 TRP A CD1 1 ATOM 3250 C CD2 . TRP A 1 420 ? 54.779 -14.853 22.439 1.00 38.50 ? 420 TRP A CD2 1 ATOM 3251 N NE1 . TRP A 1 420 ? 52.835 -15.875 21.986 1.00 40.78 ? 420 TRP A NE1 1 ATOM 3252 C CE2 . TRP A 1 420 ? 53.698 -14.914 21.530 1.00 42.22 ? 420 TRP A CE2 1 ATOM 3253 C CE3 . TRP A 1 420 ? 55.819 -13.936 22.194 1.00 39.63 ? 420 TRP A CE3 1 ATOM 3254 C CZ2 . TRP A 1 420 ? 53.634 -14.108 20.391 1.00 41.41 ? 420 TRP A CZ2 1 ATOM 3255 C CZ3 . TRP A 1 420 ? 55.750 -13.137 21.064 1.00 40.98 ? 420 TRP A CZ3 1 ATOM 3256 C CH2 . TRP A 1 420 ? 54.672 -13.233 20.174 1.00 41.61 ? 420 TRP A CH2 1 ATOM 3257 N N . ALA A 1 421 ? 54.606 -13.048 25.237 1.00 33.65 ? 421 ALA A N 1 ATOM 3258 C CA . ALA A 1 421 ? 54.937 -11.626 25.102 1.00 31.79 ? 421 ALA A CA 1 ATOM 3259 C C . ALA A 1 421 ? 54.881 -10.922 26.433 1.00 36.46 ? 421 ALA A C 1 ATOM 3260 O O . ALA A 1 421 ? 55.659 -9.999 26.674 1.00 36.73 ? 421 ALA A O 1 ATOM 3261 C CB . ALA A 1 421 ? 54.013 -10.942 24.105 1.00 31.84 ? 421 ALA A CB 1 ATOM 3262 N N . ARG A 1 422 ? 53.961 -11.361 27.301 1.00 33.83 ? 422 ARG A N 1 ATOM 3263 C CA . ARG A 1 422 ? 53.743 -10.798 28.625 1.00 33.57 ? 422 ARG A CA 1 ATOM 3264 C C . ARG A 1 422 ? 54.806 -11.277 29.581 1.00 39.59 ? 422 ARG A C 1 ATOM 3265 O O . ARG A 1 422 ? 55.400 -10.461 30.284 1.00 39.89 ? 422 ARG A O 1 ATOM 3266 C CB . ARG A 1 422 ? 52.382 -11.224 29.161 1.00 31.97 ? 422 ARG A CB 1 ATOM 3267 C CG . ARG A 1 422 ? 51.223 -10.458 28.594 1.00 41.13 ? 422 ARG A CG 1 ATOM 3268 C CD . ARG A 1 422 ? 49.908 -11.059 29.066 1.00 53.76 ? 422 ARG A CD 1 ATOM 3269 N NE . ARG A 1 422 ? 49.471 -10.510 30.350 1.00 58.83 ? 422 ARG A NE 1 ATOM 3270 C CZ . ARG A 1 422 ? 48.522 -11.047 31.107 1.00 69.21 ? 422 ARG A CZ 1 ATOM 3271 N NH1 . ARG A 1 422 ? 47.921 -12.168 30.734 1.00 48.46 ? 422 ARG A NH1 1 ATOM 3272 N NH2 . ARG A 1 422 ? 48.172 -10.472 32.250 1.00 61.51 ? 422 ARG A NH2 1 ATOM 3273 N N . MET A 1 423 ? 55.037 -12.598 29.628 1.00 37.01 ? 423 MET A N 1 ATOM 3274 C CA . MET A 1 423 ? 55.967 -13.186 30.584 1.00 37.46 ? 423 MET A CA 1 ATOM 3275 C C . MET A 1 423 ? 57.422 -12.972 30.252 1.00 41.32 ? 423 MET A C 1 ATOM 3276 O O . MET A 1 423 ? 58.176 -12.580 31.141 1.00 41.08 ? 423 MET A O 1 ATOM 3277 C CB . MET A 1 423 ? 55.673 -14.669 30.821 1.00 40.01 ? 423 MET A CB 1 ATOM 3278 C CG . MET A 1 423 ? 54.384 -14.892 31.577 1.00 43.98 ? 423 MET A CG 1 ATOM 3279 S SD . MET A 1 423 ? 54.207 -16.589 32.146 1.00 49.37 ? 423 MET A SD 1 ATOM 3280 C CE . MET A 1 423 ? 55.081 -16.499 33.717 1.00 46.41 ? 423 MET A CE 1 ATOM 3281 N N . ILE A 1 424 ? 57.824 -13.227 29.001 1.00 37.71 ? 424 ILE A N 1 ATOM 3282 C CA . ILE A 1 424 ? 59.216 -13.113 28.593 1.00 37.23 ? 424 ILE A CA 1 ATOM 3283 C C . ILE A 1 424 ? 59.563 -11.753 28.032 1.00 42.50 ? 424 ILE A C 1 ATOM 3284 O O . ILE A 1 424 ? 60.447 -11.098 28.562 1.00 43.55 ? 424 ILE A O 1 ATOM 3285 C CB . ILE A 1 424 ? 59.615 -14.251 27.624 1.00 40.24 ? 424 ILE A CB 1 ATOM 3286 C CG1 . ILE A 1 424 ? 59.435 -15.634 28.295 1.00 40.76 ? 424 ILE A CG1 1 ATOM 3287 C CG2 . ILE A 1 424 ? 61.054 -14.061 27.145 1.00 40.86 ? 424 ILE A CG2 1 ATOM 3288 C CD1 . ILE A 1 424 ? 58.808 -16.668 27.472 1.00 46.61 ? 424 ILE A CD1 1 ATOM 3289 N N . LEU A 1 425 ? 58.911 -11.340 26.946 1.00 39.26 ? 425 LEU A N 1 ATOM 3290 C CA . LEU A 1 425 ? 59.281 -10.123 26.234 1.00 38.85 ? 425 LEU A CA 1 ATOM 3291 C C . LEU A 1 425 ? 59.146 -8.850 27.055 1.00 43.56 ? 425 LEU A C 1 ATOM 3292 O O . LEU A 1 425 ? 60.137 -8.118 27.151 1.00 44.01 ? 425 LEU A O 1 ATOM 3293 C CB . LEU A 1 425 ? 58.559 -10.020 24.891 1.00 38.62 ? 425 LEU A CB 1 ATOM 3294 C CG . LEU A 1 425 ? 59.073 -11.020 23.826 1.00 42.68 ? 425 LEU A CG 1 ATOM 3295 C CD1 . LEU A 1 425 ? 58.191 -11.045 22.612 1.00 42.56 ? 425 LEU A CD1 1 ATOM 3296 C CD2 . LEU A 1 425 ? 60.491 -10.723 23.416 1.00 43.06 ? 425 LEU A CD2 1 ATOM 3297 N N . MET A 1 426 ? 57.970 -8.610 27.681 1.00 39.35 ? 426 MET A N 1 ATOM 3298 C CA . MET A 1 426 ? 57.722 -7.432 28.512 1.00 39.22 ? 426 MET A CA 1 ATOM 3299 C C . MET A 1 426 ? 58.712 -7.350 29.654 1.00 44.47 ? 426 MET A C 1 ATOM 3300 O O . MET A 1 426 ? 59.312 -6.299 29.850 1.00 44.67 ? 426 MET A O 1 ATOM 3301 C CB . MET A 1 426 ? 56.283 -7.412 29.049 1.00 41.54 ? 426 MET A CB 1 ATOM 3302 C CG . MET A 1 426 ? 55.286 -6.897 28.052 1.00 45.35 ? 426 MET A CG 1 ATOM 3303 S SD . MET A 1 426 ? 53.622 -6.793 28.728 1.00 49.25 ? 426 MET A SD 1 ATOM 3304 C CE . MET A 1 426 ? 52.687 -6.683 27.233 1.00 45.58 ? 426 MET A CE 1 ATOM 3305 N N . THR A 1 427 ? 58.914 -8.468 30.373 1.00 41.62 ? 427 THR A N 1 ATOM 3306 C CA . THR A 1 427 ? 59.819 -8.597 31.523 1.00 41.59 ? 427 THR A CA 1 ATOM 3307 C C . THR A 1 427 ? 61.263 -8.274 31.162 1.00 44.24 ? 427 THR A C 1 ATOM 3308 O O . THR A 1 427 ? 61.846 -7.359 31.746 1.00 44.32 ? 427 THR A O 1 ATOM 3309 C CB . THR A 1 427 ? 59.668 -9.991 32.131 1.00 49.70 ? 427 THR A CB 1 ATOM 3310 O OG1 . THR A 1 427 ? 58.296 -10.182 32.471 1.00 47.88 ? 427 THR A OG1 1 ATOM 3311 C CG2 . THR A 1 427 ? 60.544 -10.206 33.350 1.00 48.35 ? 427 THR A CG2 1 ATOM 3312 N N . HIS A 1 428 ? 61.824 -9.024 30.203 1.00 38.84 ? 428 HIS A N 1 ATOM 3313 C CA . HIS A 1 428 ? 63.191 -8.892 29.725 1.00 38.17 ? 428 HIS A CA 1 ATOM 3314 C C . HIS A 1 428 ? 63.524 -7.470 29.319 1.00 41.90 ? 428 HIS A C 1 ATOM 3315 O O . HIS A 1 428 ? 64.449 -6.865 29.865 1.00 42.03 ? 428 HIS A O 1 ATOM 3316 C CB . HIS A 1 428 ? 63.421 -9.860 28.549 1.00 38.90 ? 428 HIS A CB 1 ATOM 3317 C CG . HIS A 1 428 ? 64.799 -9.830 27.972 1.00 42.54 ? 428 HIS A CG 1 ATOM 3318 N ND1 . HIS A 1 428 ? 65.902 -10.270 28.698 1.00 44.43 ? 428 HIS A ND1 1 ATOM 3319 C CD2 . HIS A 1 428 ? 65.205 -9.471 26.732 1.00 44.66 ? 428 HIS A CD2 1 ATOM 3320 C CE1 . HIS A 1 428 ? 66.939 -10.135 27.887 1.00 44.19 ? 428 HIS A CE1 1 ATOM 3321 N NE2 . HIS A 1 428 ? 66.568 -9.666 26.686 1.00 44.55 ? 428 HIS A NE2 1 ATOM 3322 N N . PHE A 1 429 ? 62.747 -6.926 28.386 1.00 37.90 ? 429 PHE A N 1 ATOM 3323 C CA . PHE A 1 429 ? 63.013 -5.615 27.834 1.00 36.50 ? 429 PHE A CA 1 ATOM 3324 C C . PHE A 1 429 ? 62.733 -4.499 28.811 1.00 41.79 ? 429 PHE A C 1 ATOM 3325 O O . PHE A 1 429 ? 63.492 -3.533 28.806 1.00 41.57 ? 429 PHE A O 1 ATOM 3326 C CB . PHE A 1 429 ? 62.319 -5.434 26.486 1.00 36.82 ? 429 PHE A CB 1 ATOM 3327 C CG . PHE A 1 429 ? 63.057 -6.230 25.435 1.00 36.77 ? 429 PHE A CG 1 ATOM 3328 C CD1 . PHE A 1 429 ? 64.248 -5.759 24.892 1.00 38.07 ? 429 PHE A CD1 1 ATOM 3329 C CD2 . PHE A 1 429 ? 62.622 -7.499 25.067 1.00 38.05 ? 429 PHE A CD2 1 ATOM 3330 C CE1 . PHE A 1 429 ? 64.960 -6.517 23.956 1.00 38.21 ? 429 PHE A CE1 1 ATOM 3331 C CE2 . PHE A 1 429 ? 63.348 -8.268 24.147 1.00 39.95 ? 429 PHE A CE2 1 ATOM 3332 C CZ . PHE A 1 429 ? 64.505 -7.766 23.589 1.00 37.37 ? 429 PHE A CZ 1 ATOM 3333 N N . PHE A 1 430 ? 61.752 -4.658 29.716 1.00 39.88 ? 430 PHE A N 1 ATOM 3334 C CA . PHE A 1 430 ? 61.516 -3.616 30.713 1.00 40.95 ? 430 PHE A CA 1 ATOM 3335 C C . PHE A 1 430 ? 62.659 -3.541 31.734 1.00 44.56 ? 430 PHE A C 1 ATOM 3336 O O . PHE A 1 430 ? 63.037 -2.432 32.121 1.00 44.91 ? 430 PHE A O 1 ATOM 3337 C CB . PHE A 1 430 ? 60.132 -3.711 31.369 1.00 43.83 ? 430 PHE A CB 1 ATOM 3338 C CG . PHE A 1 430 ? 59.141 -2.786 30.693 1.00 46.99 ? 430 PHE A CG 1 ATOM 3339 C CD1 . PHE A 1 430 ? 58.341 -3.238 29.646 1.00 50.87 ? 430 PHE A CD1 1 ATOM 3340 C CD2 . PHE A 1 430 ? 59.050 -1.446 31.060 1.00 50.02 ? 430 PHE A CD2 1 ATOM 3341 C CE1 . PHE A 1 430 ? 57.463 -2.372 28.989 1.00 51.72 ? 430 PHE A CE1 1 ATOM 3342 C CE2 . PHE A 1 430 ? 58.167 -0.583 30.403 1.00 53.14 ? 430 PHE A CE2 1 ATOM 3343 C CZ . PHE A 1 430 ? 57.379 -1.053 29.373 1.00 50.98 ? 430 PHE A CZ 1 ATOM 3344 N N . SER A 1 431 ? 63.288 -4.682 32.075 1.00 39.91 ? 431 SER A N 1 ATOM 3345 C CA . SER A 1 431 ? 64.432 -4.662 32.985 1.00 39.94 ? 431 SER A CA 1 ATOM 3346 C C . SER A 1 431 ? 65.618 -3.964 32.320 1.00 44.67 ? 431 SER A C 1 ATOM 3347 O O . SER A 1 431 ? 66.321 -3.211 32.988 1.00 44.35 ? 431 SER A O 1 ATOM 3348 C CB . SER A 1 431 ? 64.799 -6.062 33.464 1.00 43.43 ? 431 SER A CB 1 ATOM 3349 O OG . SER A 1 431 ? 65.480 -6.816 32.476 1.00 54.94 ? 431 SER A OG 1 ATOM 3350 N N . ILE A 1 432 ? 65.796 -4.175 31.001 1.00 42.11 ? 432 ILE A N 1 ATOM 3351 C CA . ILE A 1 432 ? 66.834 -3.537 30.185 1.00 42.97 ? 432 ILE A CA 1 ATOM 3352 C C . ILE A 1 432 ? 66.591 -2.010 30.174 1.00 48.99 ? 432 ILE A C 1 ATOM 3353 O O . ILE A 1 432 ? 67.513 -1.258 30.476 1.00 48.49 ? 432 ILE A O 1 ATOM 3354 C CB . ILE A 1 432 ? 66.877 -4.157 28.741 1.00 45.94 ? 432 ILE A CB 1 ATOM 3355 C CG1 . ILE A 1 432 ? 67.615 -5.519 28.729 1.00 45.37 ? 432 ILE A CG1 1 ATOM 3356 C CG2 . ILE A 1 432 ? 67.452 -3.167 27.686 1.00 47.29 ? 432 ILE A CG2 1 ATOM 3357 C CD1 . ILE A 1 432 ? 67.545 -6.344 27.422 1.00 45.34 ? 432 ILE A CD1 1 ATOM 3358 N N . LEU A 1 433 ? 65.346 -1.567 29.851 1.00 46.67 ? 433 LEU A N 1 ATOM 3359 C CA . LEU A 1 433 ? 64.954 -0.149 29.815 1.00 46.75 ? 433 LEU A CA 1 ATOM 3360 C C . LEU A 1 433 ? 65.105 0.533 31.172 1.00 51.17 ? 433 LEU A C 1 ATOM 3361 O O . LEU A 1 433 ? 65.391 1.727 31.212 1.00 51.10 ? 433 LEU A O 1 ATOM 3362 C CB . LEU A 1 433 ? 63.510 0.045 29.324 1.00 46.46 ? 433 LEU A CB 1 ATOM 3363 C CG . LEU A 1 433 ? 63.122 -0.435 27.935 1.00 50.29 ? 433 LEU A CG 1 ATOM 3364 C CD1 . LEU A 1 433 ? 61.680 -0.122 27.669 1.00 50.19 ? 433 LEU A CD1 1 ATOM 3365 C CD2 . LEU A 1 433 ? 64.014 0.154 26.848 1.00 50.97 ? 433 LEU A CD2 1 ATOM 3366 N N . LEU A 1 434 ? 64.872 -0.208 32.275 1.00 47.61 ? 434 LEU A N 1 ATOM 3367 C CA . LEU A 1 434 ? 65.033 0.326 33.627 1.00 47.59 ? 434 LEU A CA 1 ATOM 3368 C C . LEU A 1 434 ? 66.535 0.563 33.903 1.00 52.74 ? 434 LEU A C 1 ATOM 3369 O O . LEU A 1 434 ? 66.914 1.672 34.297 1.00 52.12 ? 434 LEU A O 1 ATOM 3370 C CB . LEU A 1 434 ? 64.444 -0.643 34.679 1.00 47.37 ? 434 LEU A CB 1 ATOM 3371 C CG . LEU A 1 434 ? 62.935 -0.649 34.892 1.00 51.49 ? 434 LEU A CG 1 ATOM 3372 C CD1 . LEU A 1 434 ? 62.514 -1.910 35.601 1.00 51.53 ? 434 LEU A CD1 1 ATOM 3373 C CD2 . LEU A 1 434 ? 62.469 0.568 35.676 1.00 53.46 ? 434 LEU A CD2 1 ATOM 3374 N N . ALA A 1 435 ? 67.373 -0.485 33.648 1.00 49.54 ? 435 ALA A N 1 ATOM 3375 C CA . ALA A 1 435 ? 68.827 -0.538 33.830 1.00 49.52 ? 435 ALA A CA 1 ATOM 3376 C C . ALA A 1 435 ? 69.576 0.547 33.084 1.00 56.02 ? 435 ALA A C 1 ATOM 3377 O O . ALA A 1 435 ? 70.570 1.052 33.596 1.00 56.30 ? 435 ALA A O 1 ATOM 3378 C CB . ALA A 1 435 ? 69.356 -1.901 33.410 1.00 49.98 ? 435 ALA A CB 1 ATOM 3379 N N . GLN A 1 436 ? 69.115 0.883 31.871 1.00 54.69 ? 436 GLN A N 1 ATOM 3380 C CA . GLN A 1 436 ? 69.709 1.888 30.986 1.00 55.58 ? 436 GLN A CA 1 ATOM 3381 C C . GLN A 1 436 ? 69.032 3.249 31.130 1.00 62.84 ? 436 GLN A C 1 ATOM 3382 O O . GLN A 1 436 ? 69.561 4.244 30.638 1.00 62.77 ? 436 GLN A O 1 ATOM 3383 C CB . GLN A 1 436 ? 69.625 1.424 29.514 1.00 56.74 ? 436 GLN A CB 1 ATOM 3384 C CG . GLN A 1 436 ? 70.325 0.102 29.197 1.00 61.43 ? 436 GLN A CG 1 ATOM 3385 C CD . GLN A 1 436 ? 71.786 0.151 29.521 1.00 79.24 ? 436 GLN A CD 1 ATOM 3386 O OE1 . GLN A 1 436 ? 72.561 0.831 28.852 1.00 80.56 ? 436 GLN A OE1 1 ATOM 3387 N NE2 . GLN A 1 436 ? 72.188 -0.537 30.579 1.00 66.38 ? 436 GLN A NE2 1 ATOM 3388 N N . GLU A 1 437 ? 67.859 3.286 31.799 1.00 62.17 ? 437 GLU A N 1 ATOM 3389 C CA . GLU A 1 437 ? 67.003 4.467 31.998 1.00 62.93 ? 437 GLU A CA 1 ATOM 3390 C C . GLU A 1 437 ? 66.586 5.072 30.635 1.00 66.89 ? 437 GLU A C 1 ATOM 3391 O O . GLU A 1 437 ? 66.449 6.288 30.487 1.00 67.42 ? 437 GLU A O 1 ATOM 3392 C CB . GLU A 1 437 ? 67.631 5.480 32.975 1.00 64.70 ? 437 GLU A CB 1 ATOM 3393 C CG . GLU A 1 437 ? 67.604 4.989 34.418 1.00 79.87 ? 437 GLU A CG 1 ATOM 3394 C CD . GLU A 1 437 ? 68.568 5.647 35.391 1.00 104.48 ? 437 GLU A CD 1 ATOM 3395 O OE1 . GLU A 1 437 ? 68.647 6.899 35.410 1.00 102.29 ? 437 GLU A OE1 1 ATOM 3396 O OE2 . GLU A 1 437 ? 69.221 4.907 36.164 1.00 93.88 ? 437 GLU A OE2 1 ATOM 3397 N N . GLN A 1 438 ? 66.378 4.181 29.644 1.00 62.31 ? 438 GLN A N 1 ATOM 3398 C CA . GLN A 1 438 ? 65.971 4.483 28.272 1.00 61.88 ? 438 GLN A CA 1 ATOM 3399 C C . GLN A 1 438 ? 64.444 4.298 28.130 1.00 65.68 ? 438 GLN A C 1 ATOM 3400 O O . GLN A 1 438 ? 63.921 4.144 27.013 1.00 65.62 ? 438 GLN A O 1 ATOM 3401 C CB . GLN A 1 438 ? 66.724 3.570 27.280 1.00 63.07 ? 438 GLN A CB 1 ATOM 3402 C CG . GLN A 1 438 ? 68.179 3.957 27.023 1.00 72.40 ? 438 GLN A CG 1 ATOM 3403 C CD . GLN A 1 438 ? 68.766 3.235 25.826 1.00 82.73 ? 438 GLN A CD 1 ATOM 3404 O OE1 . GLN A 1 438 ? 68.773 1.999 25.745 1.00 73.74 ? 438 GLN A OE1 1 ATOM 3405 N NE2 . GLN A 1 438 ? 69.301 4.000 24.879 1.00 72.51 ? 438 GLN A NE2 1 ATOM 3406 N N . LEU A 1 439 ? 63.748 4.329 29.277 1.00 61.07 ? 439 LEU A N 1 ATOM 3407 C CA . LEU A 1 439 ? 62.307 4.158 29.426 1.00 60.69 ? 439 LEU A CA 1 ATOM 3408 C C . LEU A 1 439 ? 61.492 5.313 28.776 1.00 64.67 ? 439 LEU A C 1 ATOM 3409 O O . LEU A 1 439 ? 60.463 5.052 28.145 1.00 63.30 ? 439 LEU A O 1 ATOM 3410 C CB . LEU A 1 439 ? 62.013 4.014 30.936 1.00 60.70 ? 439 LEU A CB 1 ATOM 3411 C CG . LEU A 1 439 ? 60.901 3.065 31.390 1.00 65.20 ? 439 LEU A CG 1 ATOM 3412 C CD1 . LEU A 1 439 ? 61.137 1.654 30.946 1.00 65.11 ? 439 LEU A CD1 1 ATOM 3413 C CD2 . LEU A 1 439 ? 60.781 3.064 32.889 1.00 67.89 ? 439 LEU A CD2 1 ATOM 3414 N N . GLU A 1 440 ? 61.964 6.578 28.919 1.00 62.18 ? 440 GLU A N 1 ATOM 3415 C CA . GLU A 1 440 ? 61.328 7.777 28.349 1.00 61.64 ? 440 GLU A CA 1 ATOM 3416 C C . GLU A 1 440 ? 61.725 7.984 26.872 1.00 63.80 ? 440 GLU A C 1 ATOM 3417 O O . GLU A 1 440 ? 61.041 8.729 26.164 1.00 63.89 ? 440 GLU A O 1 ATOM 3418 C CB . GLU A 1 440 ? 61.664 9.034 29.184 1.00 63.08 ? 440 GLU A CB 1 ATOM 3419 C CG . GLU A 1 440 ? 61.246 8.975 30.644 1.00 75.30 ? 440 GLU A CG 1 ATOM 3420 C CD . GLU A 1 440 ? 60.346 10.103 31.116 1.00 102.92 ? 440 GLU A CD 1 ATOM 3421 O OE1 . GLU A 1 440 ? 59.182 9.817 31.481 1.00 98.66 ? 440 GLU A OE1 1 ATOM 3422 O OE2 . GLU A 1 440 ? 60.799 11.271 31.122 1.00 101.22 ? 440 GLU A OE2 1 ATOM 3423 N N . LYS A 1 441 ? 62.832 7.340 26.421 1.00 58.09 ? 441 LYS A N 1 ATOM 3424 C CA . LYS A 1 441 ? 63.340 7.416 25.045 1.00 57.38 ? 441 LYS A CA 1 ATOM 3425 C C . LYS A 1 441 ? 62.397 6.674 24.088 1.00 60.28 ? 441 LYS A C 1 ATOM 3426 O O . LYS A 1 441 ? 62.182 5.475 24.264 1.00 61.14 ? 441 LYS A O 1 ATOM 3427 C CB . LYS A 1 441 ? 64.760 6.814 24.970 1.00 59.94 ? 441 LYS A CB 1 ATOM 3428 C CG . LYS A 1 441 ? 65.432 6.900 23.595 1.00 71.35 ? 441 LYS A CG 1 ATOM 3429 C CD . LYS A 1 441 ? 66.681 6.008 23.511 1.00 77.83 ? 441 LYS A CD 1 ATOM 3430 C CE . LYS A 1 441 ? 67.260 5.935 22.111 1.00 77.82 ? 441 LYS A CE 1 ATOM 3431 N NZ . LYS A 1 441 ? 68.299 4.873 21.991 1.00 75.41 ? 441 LYS A NZ 1 ATOM 3432 N N . ALA A 1 442 ? 61.850 7.381 23.078 1.00 54.67 ? 442 ALA A N 1 ATOM 3433 C CA . ALA A 1 442 ? 60.958 6.804 22.069 1.00 53.67 ? 442 ALA A CA 1 ATOM 3434 C C . ALA A 1 442 ? 61.738 5.881 21.155 1.00 56.75 ? 442 ALA A C 1 ATOM 3435 O O . ALA A 1 442 ? 62.883 6.176 20.798 1.00 56.88 ? 442 ALA A O 1 ATOM 3436 C CB . ALA A 1 442 ? 60.296 7.898 21.254 1.00 54.42 ? 442 ALA A CB 1 ATOM 3437 N N . LEU A 1 443 ? 61.126 4.753 20.791 1.00 52.41 ? 443 LEU A N 1 ATOM 3438 C CA . LEU A 1 443 ? 61.763 3.753 19.940 1.00 51.40 ? 443 LEU A CA 1 ATOM 3439 C C . LEU A 1 443 ? 61.025 3.521 18.631 1.00 55.02 ? 443 LEU A C 1 ATOM 3440 O O . LEU A 1 443 ? 59.794 3.547 18.595 1.00 53.33 ? 443 LEU A O 1 ATOM 3441 C CB . LEU A 1 443 ? 61.983 2.434 20.703 1.00 50.81 ? 443 LEU A CB 1 ATOM 3442 C CG . LEU A 1 443 ? 63.030 2.475 21.816 1.00 54.16 ? 443 LEU A CG 1 ATOM 3443 C CD1 . LEU A 1 443 ? 62.794 1.386 22.812 1.00 53.76 ? 443 LEU A CD1 1 ATOM 3444 C CD2 . LEU A 1 443 ? 64.445 2.416 21.262 1.00 54.31 ? 443 LEU A CD2 1 ATOM 3445 N N . ASP A 1 444 ? 61.793 3.305 17.558 1.00 53.34 ? 444 ASP A N 1 ATOM 3446 C CA . ASP A 1 444 ? 61.269 3.062 16.220 1.00 54.20 ? 444 ASP A CA 1 ATOM 3447 C C . ASP A 1 444 ? 60.978 1.577 16.007 1.00 58.32 ? 444 ASP A C 1 ATOM 3448 O O . ASP A 1 444 ? 61.902 0.761 16.048 1.00 58.66 ? 444 ASP A O 1 ATOM 3449 C CB . ASP A 1 444 ? 62.265 3.566 15.148 1.00 56.77 ? 444 ASP A CB 1 ATOM 3450 C CG . ASP A 1 444 ? 62.162 5.031 14.741 1.00 74.28 ? 444 ASP A CG 1 ATOM 3451 O OD1 . ASP A 1 444 ? 61.335 5.766 15.341 1.00 77.18 ? 444 ASP A OD1 1 ATOM 3452 O OD2 . ASP A 1 444 ? 62.899 5.440 13.809 1.00 79.50 ? 444 ASP A OD2 1 ATOM 3453 N N . CYS A 1 445 ? 59.708 1.221 15.782 1.00 54.17 ? 445 CYS A N 1 ATOM 3454 C CA . CYS A 1 445 ? 59.337 -0.161 15.487 1.00 54.39 ? 445 CYS A CA 1 ATOM 3455 C C . CYS A 1 445 ? 58.489 -0.266 14.212 1.00 57.97 ? 445 CYS A C 1 ATOM 3456 O O . CYS A 1 445 ? 58.292 0.743 13.539 1.00 56.80 ? 445 CYS A O 1 ATOM 3457 C CB . CYS A 1 445 ? 58.685 -0.842 16.689 1.00 55.06 ? 445 CYS A CB 1 ATOM 3458 S SG . CYS A 1 445 ? 57.013 -0.265 17.073 1.00 58.86 ? 445 CYS A SG 1 ATOM 3459 N N . GLN A 1 446 ? 58.047 -1.482 13.844 1.00 56.11 ? 446 GLN A N 1 ATOM 3460 C CA . GLN A 1 446 ? 57.244 -1.708 12.639 1.00 56.65 ? 446 GLN A CA 1 ATOM 3461 C C . GLN A 1 446 ? 55.985 -2.495 12.905 1.00 61.59 ? 446 GLN A C 1 ATOM 3462 O O . GLN A 1 446 ? 56.030 -3.544 13.544 1.00 61.02 ? 446 GLN A O 1 ATOM 3463 C CB . GLN A 1 446 ? 58.060 -2.368 11.517 1.00 58.14 ? 446 GLN A CB 1 ATOM 3464 C CG . GLN A 1 446 ? 58.801 -1.370 10.635 1.00 71.21 ? 446 GLN A CG 1 ATOM 3465 C CD . GLN A 1 446 ? 59.107 -1.935 9.268 1.00 86.51 ? 446 GLN A CD 1 ATOM 3466 O OE1 . GLN A 1 446 ? 58.241 -2.514 8.593 1.00 80.41 ? 446 GLN A OE1 1 ATOM 3467 N NE2 . GLN A 1 446 ? 60.333 -1.731 8.804 1.00 78.19 ? 446 GLN A NE2 1 ATOM 3468 N N . ILE A 1 447 ? 54.860 -1.984 12.408 1.00 60.06 ? 447 ILE A N 1 ATOM 3469 C CA . ILE A 1 447 ? 53.545 -2.598 12.548 1.00 61.37 ? 447 ILE A CA 1 ATOM 3470 C C . ILE A 1 447 ? 52.888 -2.597 11.168 1.00 69.17 ? 447 ILE A C 1 ATOM 3471 O O . ILE A 1 447 ? 52.815 -1.536 10.539 1.00 70.30 ? 447 ILE A O 1 ATOM 3472 C CB . ILE A 1 447 ? 52.706 -1.870 13.642 1.00 64.51 ? 447 ILE A CB 1 ATOM 3473 C CG1 . ILE A 1 447 ? 53.206 -2.237 15.059 1.00 64.74 ? 447 ILE A CG1 1 ATOM 3474 C CG2 . ILE A 1 447 ? 51.193 -2.143 13.503 1.00 65.53 ? 447 ILE A CG2 1 ATOM 3475 C CD1 . ILE A 1 447 ? 53.647 -1.082 15.867 1.00 69.02 ? 447 ILE A CD1 1 ATOM 3476 N N . TYR A 1 448 ? 52.436 -3.789 10.687 1.00 66.04 ? 448 TYR A N 1 ATOM 3477 C CA . TYR A 1 448 ? 51.805 -4.006 9.364 1.00 65.54 ? 448 TYR A CA 1 ATOM 3478 C C . TYR A 1 448 ? 52.705 -3.504 8.193 1.00 69.05 ? 448 TYR A C 1 ATOM 3479 O O . TYR A 1 448 ? 52.206 -3.176 7.111 1.00 68.79 ? 448 TYR A O 1 ATOM 3480 C CB . TYR A 1 448 ? 50.372 -3.394 9.295 1.00 66.17 ? 448 TYR A CB 1 ATOM 3481 C CG . TYR A 1 448 ? 49.262 -4.164 9.992 1.00 66.92 ? 448 TYR A CG 1 ATOM 3482 C CD1 . TYR A 1 448 ? 49.528 -5.339 10.694 1.00 68.74 ? 448 TYR A CD1 1 ATOM 3483 C CD2 . TYR A 1 448 ? 47.944 -3.718 9.948 1.00 66.91 ? 448 TYR A CD2 1 ATOM 3484 C CE1 . TYR A 1 448 ? 48.514 -6.038 11.349 1.00 68.40 ? 448 TYR A CE1 1 ATOM 3485 C CE2 . TYR A 1 448 ? 46.919 -4.421 10.582 1.00 67.34 ? 448 TYR A CE2 1 ATOM 3486 C CZ . TYR A 1 448 ? 47.209 -5.578 11.290 1.00 72.26 ? 448 TYR A CZ 1 ATOM 3487 O OH . TYR A 1 448 ? 46.203 -6.281 11.913 1.00 67.97 ? 448 TYR A OH 1 ATOM 3488 N N . GLY A 1 449 ? 54.018 -3.456 8.444 1.00 64.47 ? 449 GLY A N 1 ATOM 3489 C CA . GLY A 1 449 ? 55.016 -2.982 7.495 1.00 63.51 ? 449 GLY A CA 1 ATOM 3490 C C . GLY A 1 449 ? 55.263 -1.487 7.560 1.00 65.57 ? 449 GLY A C 1 ATOM 3491 O O . GLY A 1 449 ? 56.155 -0.988 6.866 1.00 65.31 ? 449 GLY A O 1 ATOM 3492 N N . ALA A 1 450 ? 54.462 -0.758 8.383 1.00 60.70 ? 450 ALA A N 1 ATOM 3493 C CA . ALA A 1 450 ? 54.543 0.698 8.597 1.00 59.59 ? 450 ALA A CA 1 ATOM 3494 C C . ALA A 1 450 ? 55.443 1.025 9.795 1.00 61.19 ? 450 ALA A C 1 ATOM 3495 O O . ALA A 1 450 ? 55.363 0.346 10.823 1.00 60.11 ? 450 ALA A O 1 ATOM 3496 C CB . ALA A 1 450 ? 53.149 1.284 8.818 1.00 60.11 ? 450 ALA A CB 1 ATOM 3497 N N A CYS A 1 451 ? 56.289 2.060 9.659 0.50 57.51 ? 451 CYS A N 1 ATOM 3498 N N B CYS A 1 451 ? 56.306 2.049 9.656 0.50 57.05 ? 451 CYS A N 1 ATOM 3499 C CA A CYS A 1 451 ? 57.207 2.485 10.714 0.50 57.26 ? 451 CYS A CA 1 ATOM 3500 C CA B CYS A 1 451 ? 57.204 2.456 10.735 0.50 56.59 ? 451 CYS A CA 1 ATOM 3501 C C A CYS A 1 451 ? 56.537 3.388 11.756 0.50 60.65 ? 451 CYS A C 1 ATOM 3502 C C B CYS A 1 451 ? 56.502 3.349 11.759 0.50 60.35 ? 451 CYS A C 1 ATOM 3503 O O A CYS A 1 451 ? 55.829 4.329 11.397 0.50 60.35 ? 451 CYS A O 1 ATOM 3504 O O B CYS A 1 451 ? 55.755 4.256 11.390 0.50 60.04 ? 451 CYS A O 1 ATOM 3505 C CB A CYS A 1 451 ? 58.458 3.127 10.126 0.50 57.54 ? 451 CYS A CB 1 ATOM 3506 C CB B CYS A 1 451 ? 58.475 3.106 10.198 0.50 56.63 ? 451 CYS A CB 1 ATOM 3507 S SG A CYS A 1 451 ? 59.985 2.222 10.482 0.50 61.54 ? 451 CYS A SG 1 ATOM 3508 S SG B CYS A 1 451 ? 59.683 3.532 11.484 0.50 60.45 ? 451 CYS A SG 1 ATOM 3509 N N . TYR A 1 452 ? 56.762 3.091 13.047 1.00 56.49 ? 452 TYR A N 1 ATOM 3510 C CA . TYR A 1 452 ? 56.184 3.836 14.167 1.00 55.48 ? 452 TYR A CA 1 ATOM 3511 C C . TYR A 1 452 ? 57.227 4.221 15.180 1.00 57.46 ? 452 TYR A C 1 ATOM 3512 O O . TYR A 1 452 ? 58.137 3.440 15.447 1.00 56.92 ? 452 TYR A O 1 ATOM 3513 C CB . TYR A 1 452 ? 55.116 2.982 14.876 1.00 56.06 ? 452 TYR A CB 1 ATOM 3514 C CG . TYR A 1 452 ? 53.756 3.066 14.231 1.00 57.88 ? 452 TYR A CG 1 ATOM 3515 C CD1 . TYR A 1 452 ? 53.391 2.192 13.209 1.00 59.73 ? 452 TYR A CD1 1 ATOM 3516 C CD2 . TYR A 1 452 ? 52.840 4.041 14.617 1.00 58.74 ? 452 TYR A CD2 1 ATOM 3517 C CE1 . TYR A 1 452 ? 52.144 2.281 12.595 1.00 60.50 ? 452 TYR A CE1 1 ATOM 3518 C CE2 . TYR A 1 452 ? 51.585 4.130 14.019 1.00 59.60 ? 452 TYR A CE2 1 ATOM 3519 C CZ . TYR A 1 452 ? 51.246 3.255 13.002 1.00 68.55 ? 452 TYR A CZ 1 ATOM 3520 O OH . TYR A 1 452 ? 50.021 3.362 12.395 1.00 73.29 ? 452 TYR A OH 1 ATOM 3521 N N . SER A 1 453 ? 57.073 5.403 15.780 1.00 52.20 ? 453 SER A N 1 ATOM 3522 C CA . SER A 1 453 ? 57.921 5.814 16.890 1.00 50.92 ? 453 SER A CA 1 ATOM 3523 C C . SER A 1 453 ? 57.008 5.721 18.125 1.00 52.62 ? 453 SER A C 1 ATOM 3524 O O . SER A 1 453 ? 55.982 6.409 18.198 1.00 50.97 ? 453 SER A O 1 ATOM 3525 C CB . SER A 1 453 ? 58.472 7.221 16.690 1.00 53.75 ? 453 SER A CB 1 ATOM 3526 O OG . SER A 1 453 ? 59.626 7.426 17.489 1.00 63.29 ? 453 SER A OG 1 ATOM 3527 N N . ILE A 1 454 ? 57.324 4.785 19.035 1.00 48.64 ? 454 ILE A N 1 ATOM 3528 C CA . ILE A 1 454 ? 56.524 4.549 20.233 1.00 47.87 ? 454 ILE A CA 1 ATOM 3529 C C . ILE A 1 454 ? 57.308 4.835 21.499 1.00 52.60 ? 454 ILE A C 1 ATOM 3530 O O . ILE A 1 454 ? 58.464 4.433 21.617 1.00 51.90 ? 454 ILE A O 1 ATOM 3531 C CB . ILE A 1 454 ? 55.898 3.122 20.202 1.00 50.12 ? 454 ILE A CB 1 ATOM 3532 C CG1 . ILE A 1 454 ? 54.584 3.146 19.409 1.00 49.95 ? 454 ILE A CG1 1 ATOM 3533 C CG2 . ILE A 1 454 ? 55.671 2.525 21.604 1.00 49.67 ? 454 ILE A CG2 1 ATOM 3534 C CD1 . ILE A 1 454 ? 54.444 2.085 18.427 1.00 48.75 ? 454 ILE A CD1 1 ATOM 3535 N N . GLU A 1 455 ? 56.668 5.537 22.444 1.00 50.42 ? 455 GLU A N 1 ATOM 3536 C CA . GLU A 1 455 ? 57.241 5.810 23.751 1.00 50.61 ? 455 GLU A CA 1 ATOM 3537 C C . GLU A 1 455 ? 56.925 4.564 24.594 1.00 54.28 ? 455 GLU A C 1 ATOM 3538 O O . GLU A 1 455 ? 55.743 4.288 24.823 1.00 53.17 ? 455 GLU A O 1 ATOM 3539 C CB . GLU A 1 455 ? 56.616 7.071 24.369 1.00 52.19 ? 455 GLU A CB 1 ATOM 3540 C CG . GLU A 1 455 ? 57.132 8.385 23.799 1.00 61.81 ? 455 GLU A CG 1 ATOM 3541 C CD . GLU A 1 455 ? 57.828 9.287 24.803 1.00 82.80 ? 455 GLU A CD 1 ATOM 3542 O OE1 . GLU A 1 455 ? 57.328 9.428 25.942 1.00 71.26 ? 455 GLU A OE1 1 ATOM 3543 O OE2 . GLU A 1 455 ? 58.874 9.868 24.443 1.00 83.26 ? 455 GLU A OE2 1 ATOM 3544 N N . PRO A 1 456 ? 57.945 3.751 24.994 1.00 51.24 ? 456 PRO A N 1 ATOM 3545 C CA . PRO A 1 456 ? 57.659 2.511 25.755 1.00 50.99 ? 456 PRO A CA 1 ATOM 3546 C C . PRO A 1 456 ? 56.795 2.664 27.020 1.00 55.99 ? 456 PRO A C 1 ATOM 3547 O O . PRO A 1 456 ? 56.140 1.700 27.414 1.00 55.94 ? 456 PRO A O 1 ATOM 3548 C CB . PRO A 1 456 ? 59.053 1.969 26.074 1.00 52.25 ? 456 PRO A CB 1 ATOM 3549 C CG . PRO A 1 456 ? 59.912 2.496 24.968 1.00 56.20 ? 456 PRO A CG 1 ATOM 3550 C CD . PRO A 1 456 ? 59.396 3.889 24.745 1.00 51.98 ? 456 PRO A CD 1 ATOM 3551 N N . LEU A 1 457 ? 56.751 3.863 27.627 1.00 53.05 ? 457 LEU A N 1 ATOM 3552 C CA . LEU A 1 457 ? 55.931 4.116 28.814 1.00 52.96 ? 457 LEU A CA 1 ATOM 3553 C C . LEU A 1 457 ? 54.441 4.221 28.495 1.00 57.58 ? 457 LEU A C 1 ATOM 3554 O O . LEU A 1 457 ? 53.607 4.042 29.391 1.00 57.94 ? 457 LEU A O 1 ATOM 3555 C CB . LEU A 1 457 ? 56.438 5.340 29.589 1.00 53.02 ? 457 LEU A CB 1 ATOM 3556 C CG . LEU A 1 457 ? 57.738 5.116 30.376 1.00 57.54 ? 457 LEU A CG 1 ATOM 3557 C CD1 . LEU A 1 457 ? 58.478 6.415 30.616 1.00 57.28 ? 457 LEU A CD1 1 ATOM 3558 C CD2 . LEU A 1 457 ? 57.471 4.381 31.676 1.00 59.93 ? 457 LEU A CD2 1 ATOM 3559 N N . ASP A 1 458 ? 54.107 4.468 27.211 1.00 54.12 ? 458 ASP A N 1 ATOM 3560 C CA . ASP A 1 458 ? 52.733 4.568 26.708 1.00 53.74 ? 458 ASP A CA 1 ATOM 3561 C C . ASP A 1 458 ? 52.138 3.200 26.346 1.00 57.24 ? 458 ASP A C 1 ATOM 3562 O O . ASP A 1 458 ? 50.980 3.131 25.927 1.00 57.54 ? 458 ASP A O 1 ATOM 3563 C CB . ASP A 1 458 ? 52.656 5.527 25.502 1.00 55.28 ? 458 ASP A CB 1 ATOM 3564 C CG . ASP A 1 458 ? 52.850 6.987 25.842 1.00 63.46 ? 458 ASP A CG 1 ATOM 3565 O OD1 . ASP A 1 458 ? 52.223 7.460 26.813 1.00 65.81 ? 458 ASP A OD1 1 ATOM 3566 O OD2 . ASP A 1 458 ? 53.574 7.672 25.101 1.00 66.83 ? 458 ASP A OD2 1 ATOM 3567 N N . LEU A 1 459 ? 52.913 2.119 26.531 1.00 52.75 ? 459 LEU A N 1 ATOM 3568 C CA . LEU A 1 459 ? 52.483 0.761 26.224 1.00 52.84 ? 459 LEU A CA 1 ATOM 3569 C C . LEU A 1 459 ? 51.142 0.353 26.864 1.00 57.94 ? 459 LEU A C 1 ATOM 3570 O O . LEU A 1 459 ? 50.331 -0.177 26.109 1.00 57.48 ? 459 LEU A O 1 ATOM 3571 C CB . LEU A 1 459 ? 53.574 -0.272 26.526 1.00 52.86 ? 459 LEU A CB 1 ATOM 3572 C CG . LEU A 1 459 ? 54.554 -0.495 25.379 1.00 57.50 ? 459 LEU A CG 1 ATOM 3573 C CD1 . LEU A 1 459 ? 55.754 -1.293 25.836 1.00 57.94 ? 459 LEU A CD1 1 ATOM 3574 C CD2 . LEU A 1 459 ? 53.880 -1.172 24.209 1.00 58.96 ? 459 LEU A CD2 1 ATOM 3575 N N . PRO A 1 460 ? 50.818 0.620 28.167 1.00 55.61 ? 460 PRO A N 1 ATOM 3576 C CA . PRO A 1 460 ? 49.491 0.214 28.677 1.00 55.78 ? 460 PRO A CA 1 ATOM 3577 C C . PRO A 1 460 ? 48.327 0.909 27.966 1.00 61.43 ? 460 PRO A C 1 ATOM 3578 O O . PRO A 1 460 ? 47.273 0.297 27.786 1.00 61.76 ? 460 PRO A O 1 ATOM 3579 C CB . PRO A 1 460 ? 49.550 0.570 30.167 1.00 57.27 ? 460 PRO A CB 1 ATOM 3580 C CG . PRO A 1 460 ? 50.997 0.701 30.479 1.00 61.54 ? 460 PRO A CG 1 ATOM 3581 C CD . PRO A 1 460 ? 51.615 1.249 29.242 1.00 57.07 ? 460 PRO A CD 1 ATOM 3582 N N . GLN A 1 461 ? 48.533 2.172 27.527 1.00 58.47 ? 461 GLN A N 1 ATOM 3583 C CA . GLN A 1 461 ? 47.538 2.966 26.788 1.00 58.08 ? 461 GLN A CA 1 ATOM 3584 C C . GLN A 1 461 ? 47.312 2.321 25.416 1.00 58.89 ? 461 GLN A C 1 ATOM 3585 O O . GLN A 1 461 ? 46.169 1.984 25.099 1.00 58.78 ? 461 GLN A O 1 ATOM 3586 C CB . GLN A 1 461 ? 47.982 4.443 26.634 1.00 59.84 ? 461 GLN A CB 1 ATOM 3587 C CG . GLN A 1 461 ? 48.039 5.243 27.948 1.00 78.68 ? 461 GLN A CG 1 ATOM 3588 C CD . GLN A 1 461 ? 49.400 5.232 28.610 1.00 94.67 ? 461 GLN A CD 1 ATOM 3589 O OE1 . GLN A 1 461 ? 49.749 4.320 29.373 1.00 87.32 ? 461 GLN A OE1 1 ATOM 3590 N NE2 . GLN A 1 461 ? 50.173 6.288 28.385 1.00 86.70 ? 461 GLN A NE2 1 ATOM 3591 N N . ILE A 1 462 ? 48.423 2.078 24.654 1.00 52.21 ? 462 ILE A N 1 ATOM 3592 C CA . ILE A 1 462 ? 48.445 1.450 23.324 1.00 50.60 ? 462 ILE A CA 1 ATOM 3593 C C . ILE A 1 462 ? 47.814 0.055 23.345 1.00 52.41 ? 462 ILE A C 1 ATOM 3594 O O . ILE A 1 462 ? 47.019 -0.264 22.456 1.00 51.38 ? 462 ILE A O 1 ATOM 3595 C CB . ILE A 1 462 ? 49.867 1.433 22.682 1.00 53.37 ? 462 ILE A CB 1 ATOM 3596 C CG1 . ILE A 1 462 ? 50.508 2.832 22.682 1.00 53.66 ? 462 ILE A CG1 1 ATOM 3597 C CG2 . ILE A 1 462 ? 49.836 0.846 21.251 1.00 53.84 ? 462 ILE A CG2 1 ATOM 3598 C CD1 . ILE A 1 462 ? 52.004 2.852 22.425 1.00 60.19 ? 462 ILE A CD1 1 ATOM 3599 N N . ILE A 1 463 ? 48.160 -0.767 24.357 1.00 48.00 ? 463 ILE A N 1 ATOM 3600 C CA . ILE A 1 463 ? 47.654 -2.143 24.474 1.00 47.18 ? 463 ILE A CA 1 ATOM 3601 C C . ILE A 1 463 ? 46.147 -2.146 24.701 1.00 51.99 ? 463 ILE A C 1 ATOM 3602 O O . ILE A 1 463 ? 45.444 -2.890 24.007 1.00 50.96 ? 463 ILE A O 1 ATOM 3603 C CB . ILE A 1 463 ? 48.445 -3.008 25.497 1.00 48.97 ? 463 ILE A CB 1 ATOM 3604 C CG1 . ILE A 1 463 ? 49.853 -3.305 24.942 1.00 48.15 ? 463 ILE A CG1 1 ATOM 3605 C CG2 . ILE A 1 463 ? 47.700 -4.312 25.821 1.00 48.54 ? 463 ILE A CG2 1 ATOM 3606 C CD1 . ILE A 1 463 ? 50.904 -3.558 25.924 1.00 51.11 ? 463 ILE A CD1 1 ATOM 3607 N N . GLU A 1 464 ? 45.652 -1.278 25.616 1.00 49.52 ? 464 GLU A N 1 ATOM 3608 C CA . GLU A 1 464 ? 44.225 -1.147 25.902 1.00 49.91 ? 464 GLU A CA 1 ATOM 3609 C C . GLU A 1 464 ? 43.494 -0.806 24.609 1.00 55.19 ? 464 GLU A C 1 ATOM 3610 O O . GLU A 1 464 ? 42.507 -1.457 24.295 1.00 55.76 ? 464 GLU A O 1 ATOM 3611 C CB . GLU A 1 464 ? 43.982 -0.067 26.967 1.00 51.52 ? 464 GLU A CB 1 ATOM 3612 C CG . GLU A 1 464 ? 42.519 0.135 27.345 1.00 63.25 ? 464 GLU A CG 1 ATOM 3613 C CD . GLU A 1 464 ? 42.189 1.095 28.483 1.00 82.64 ? 464 GLU A CD 1 ATOM 3614 O OE1 . GLU A 1 464 ? 43.039 1.937 28.860 1.00 64.59 ? 464 GLU A OE1 1 ATOM 3615 O OE2 . GLU A 1 464 ? 41.051 1.003 28.995 1.00 79.71 ? 464 GLU A OE2 1 ATOM 3616 N N . ARG A 1 465 ? 44.034 0.139 23.816 1.00 51.63 ? 465 ARG A N 1 ATOM 3617 C CA . ARG A 1 465 ? 43.432 0.564 22.550 1.00 51.36 ? 465 ARG A CA 1 ATOM 3618 C C . ARG A 1 465 ? 43.489 -0.493 21.403 1.00 54.70 ? 465 ARG A C 1 ATOM 3619 O O . ARG A 1 465 ? 42.807 -0.303 20.398 1.00 54.39 ? 465 ARG A O 1 ATOM 3620 C CB . ARG A 1 465 ? 44.031 1.910 22.082 1.00 52.57 ? 465 ARG A CB 1 ATOM 3621 C CG . ARG A 1 465 ? 43.862 3.107 23.048 1.00 67.29 ? 465 ARG A CG 1 ATOM 3622 C CD . ARG A 1 465 ? 42.468 3.722 23.199 1.00 87.29 ? 465 ARG A CD 1 ATOM 3623 N NE . ARG A 1 465 ? 42.319 4.969 22.442 1.00 104.41 ? 465 ARG A NE 1 ATOM 3624 C CZ . ARG A 1 465 ? 41.233 5.739 22.463 1.00 117.69 ? 465 ARG A CZ 1 ATOM 3625 N NH1 . ARG A 1 465 ? 40.185 5.403 23.204 1.00 104.36 ? 465 ARG A NH1 1 ATOM 3626 N NH2 . ARG A 1 465 ? 41.189 6.853 21.744 1.00 101.31 ? 465 ARG A NH2 1 ATOM 3627 N N . LEU A 1 466 ? 44.292 -1.574 21.541 1.00 50.88 ? 466 LEU A N 1 ATOM 3628 C CA . LEU A 1 466 ? 44.412 -2.624 20.513 1.00 50.57 ? 466 LEU A CA 1 ATOM 3629 C C . LEU A 1 466 ? 43.746 -3.965 20.909 1.00 55.86 ? 466 LEU A C 1 ATOM 3630 O O . LEU A 1 466 ? 43.436 -4.773 20.018 1.00 55.76 ? 466 LEU A O 1 ATOM 3631 C CB . LEU A 1 466 ? 45.898 -2.928 20.193 1.00 50.46 ? 466 LEU A CB 1 ATOM 3632 C CG . LEU A 1 466 ? 46.851 -1.893 19.558 1.00 54.98 ? 466 LEU A CG 1 ATOM 3633 C CD1 . LEU A 1 466 ? 47.767 -2.563 18.562 1.00 54.15 ? 466 LEU A CD1 1 ATOM 3634 C CD2 . LEU A 1 466 ? 46.122 -0.720 18.891 1.00 58.41 ? 466 LEU A CD2 1 ATOM 3635 N N . HIS A 1 467 ? 43.601 -4.230 22.242 1.00 51.82 ? 467 HIS A N 1 ATOM 3636 C CA . HIS A 1 467 ? 43.116 -5.499 22.801 1.00 50.82 ? 467 HIS A CA 1 ATOM 3637 C C . HIS A 1 467 ? 42.072 -5.368 23.919 1.00 54.96 ? 467 HIS A C 1 ATOM 3638 O O . HIS A 1 467 ? 41.342 -6.324 24.175 1.00 54.80 ? 467 HIS A O 1 ATOM 3639 C CB . HIS A 1 467 ? 44.313 -6.307 23.355 1.00 50.98 ? 467 HIS A CB 1 ATOM 3640 C CG . HIS A 1 467 ? 45.469 -6.442 22.411 1.00 53.94 ? 467 HIS A CG 1 ATOM 3641 N ND1 . HIS A 1 467 ? 45.493 -7.422 21.434 1.00 55.67 ? 467 HIS A ND1 1 ATOM 3642 C CD2 . HIS A 1 467 ? 46.607 -5.718 22.331 1.00 54.90 ? 467 HIS A CD2 1 ATOM 3643 C CE1 . HIS A 1 467 ? 46.636 -7.257 20.790 1.00 54.56 ? 467 HIS A CE1 1 ATOM 3644 N NE2 . HIS A 1 467 ? 47.339 -6.246 21.298 1.00 54.64 ? 467 HIS A NE2 1 ATOM 3645 N N . GLY A 1 468 ? 42.059 -4.229 24.606 1.00 51.38 ? 468 GLY A N 1 ATOM 3646 C CA . GLY A 1 468 ? 41.193 -3.985 25.752 1.00 51.29 ? 468 GLY A CA 1 ATOM 3647 C C . GLY A 1 468 ? 41.946 -4.192 27.054 1.00 55.93 ? 468 GLY A C 1 ATOM 3648 O O . GLY A 1 468 ? 43.133 -4.547 27.036 1.00 55.69 ? 468 GLY A O 1 ATOM 3649 N N . LEU A 1 469 ? 41.255 -3.990 28.198 1.00 52.24 ? 469 LEU A N 1 ATOM 3650 C CA . LEU A 1 469 ? 41.822 -4.160 29.539 1.00 51.95 ? 469 LEU A CA 1 ATOM 3651 C C . LEU A 1 469 ? 42.048 -5.637 29.830 1.00 56.53 ? 469 LEU A C 1 ATOM 3652 O O . LEU A 1 469 ? 42.877 -5.979 30.682 1.00 57.25 ? 469 LEU A O 1 ATOM 3653 C CB . LEU A 1 469 ? 40.910 -3.548 30.628 1.00 51.99 ? 469 LEU A CB 1 ATOM 3654 C CG . LEU A 1 469 ? 40.801 -2.010 30.725 1.00 56.90 ? 469 LEU A CG 1 ATOM 3655 C CD1 . LEU A 1 469 ? 39.689 -1.603 31.697 1.00 56.80 ? 469 LEU A CD1 1 ATOM 3656 C CD2 . LEU A 1 469 ? 42.123 -1.375 31.170 1.00 59.47 ? 469 LEU A CD2 1 ATOM 3657 N N . SER A 1 470 ? 41.331 -6.509 29.096 1.00 52.09 ? 470 SER A N 1 ATOM 3658 C CA . SER A 1 470 ? 41.391 -7.968 29.228 1.00 51.73 ? 470 SER A CA 1 ATOM 3659 C C . SER A 1 470 ? 42.788 -8.529 29.032 1.00 54.86 ? 470 SER A C 1 ATOM 3660 O O . SER A 1 470 ? 43.142 -9.496 29.701 1.00 55.04 ? 470 SER A O 1 ATOM 3661 C CB . SER A 1 470 ? 40.406 -8.639 28.277 1.00 55.42 ? 470 SER A CB 1 ATOM 3662 O OG . SER A 1 470 ? 40.262 -7.919 27.061 1.00 65.09 ? 470 SER A OG 1 ATOM 3663 N N . ALA A 1 471 ? 43.593 -7.896 28.149 1.00 50.02 ? 471 ALA A N 1 ATOM 3664 C CA . ALA A 1 471 ? 44.971 -8.279 27.830 1.00 48.74 ? 471 ALA A CA 1 ATOM 3665 C C . ALA A 1 471 ? 45.851 -8.293 29.077 1.00 51.34 ? 471 ALA A C 1 ATOM 3666 O O . ALA A 1 471 ? 46.763 -9.117 29.180 1.00 49.43 ? 471 ALA A O 1 ATOM 3667 C CB . ALA A 1 471 ? 45.547 -7.322 26.801 1.00 49.29 ? 471 ALA A CB 1 ATOM 3668 N N . PHE A 1 472 ? 45.554 -7.388 30.030 1.00 48.70 ? 472 PHE A N 1 ATOM 3669 C CA . PHE A 1 472 ? 46.281 -7.245 31.294 1.00 48.56 ? 472 PHE A CA 1 ATOM 3670 C C . PHE A 1 472 ? 45.733 -8.174 32.368 1.00 54.07 ? 472 PHE A C 1 ATOM 3671 O O . PHE A 1 472 ? 46.314 -8.236 33.449 1.00 55.40 ? 472 PHE A O 1 ATOM 3672 C CB . PHE A 1 472 ? 46.227 -5.783 31.797 1.00 49.89 ? 472 PHE A CB 1 ATOM 3673 C CG . PHE A 1 472 ? 46.588 -4.711 30.793 1.00 50.77 ? 472 PHE A CG 1 ATOM 3674 C CD1 . PHE A 1 472 ? 47.906 -4.536 30.376 1.00 53.10 ? 472 PHE A CD1 1 ATOM 3675 C CD2 . PHE A 1 472 ? 45.613 -3.868 30.272 1.00 52.07 ? 472 PHE A CD2 1 ATOM 3676 C CE1 . PHE A 1 472 ? 48.235 -3.551 29.439 1.00 53.63 ? 472 PHE A CE1 1 ATOM 3677 C CE2 . PHE A 1 472 ? 45.946 -2.878 29.344 1.00 54.68 ? 472 PHE A CE2 1 ATOM 3678 C CZ . PHE A 1 472 ? 47.257 -2.719 28.943 1.00 52.39 ? 472 PHE A CZ 1 ATOM 3679 N N . SER A 1 473 ? 44.612 -8.877 32.085 1.00 49.72 ? 473 SER A N 1 ATOM 3680 C CA . SER A 1 473 ? 43.937 -9.770 33.032 1.00 48.72 ? 473 SER A CA 1 ATOM 3681 C C . SER A 1 473 ? 43.828 -11.227 32.565 1.00 50.56 ? 473 SER A C 1 ATOM 3682 O O . SER A 1 473 ? 43.254 -12.046 33.291 1.00 50.92 ? 473 SER A O 1 ATOM 3683 C CB . SER A 1 473 ? 42.546 -9.231 33.368 1.00 52.57 ? 473 SER A CB 1 ATOM 3684 O OG . SER A 1 473 ? 42.571 -7.879 33.799 1.00 62.41 ? 473 SER A OG 1 ATOM 3685 N N . LEU A 1 474 ? 44.359 -11.562 31.376 1.00 44.71 ? 474 LEU A N 1 ATOM 3686 C CA . LEU A 1 474 ? 44.276 -12.924 30.845 1.00 43.31 ? 474 LEU A CA 1 ATOM 3687 C C . LEU A 1 474 ? 44.995 -13.933 31.706 1.00 46.91 ? 474 LEU A C 1 ATOM 3688 O O . LEU A 1 474 ? 46.047 -13.623 32.266 1.00 46.46 ? 474 LEU A O 1 ATOM 3689 C CB . LEU A 1 474 ? 44.795 -13.030 29.405 1.00 43.04 ? 474 LEU A CB 1 ATOM 3690 C CG . LEU A 1 474 ? 43.957 -12.509 28.235 1.00 47.83 ? 474 LEU A CG 1 ATOM 3691 C CD1 . LEU A 1 474 ? 44.232 -13.328 26.995 1.00 47.89 ? 474 LEU A CD1 1 ATOM 3692 C CD2 . LEU A 1 474 ? 42.454 -12.547 28.517 1.00 50.37 ? 474 LEU A CD2 1 ATOM 3693 N N . HIS A 1 475 ? 44.420 -15.145 31.802 1.00 43.70 ? 475 HIS A N 1 ATOM 3694 C CA . HIS A 1 475 ? 44.948 -16.298 32.546 1.00 43.35 ? 475 HIS A CA 1 ATOM 3695 C C . HIS A 1 475 ? 44.386 -17.615 31.971 1.00 48.15 ? 475 HIS A C 1 ATOM 3696 O O . HIS A 1 475 ? 43.570 -17.574 31.048 1.00 48.40 ? 475 HIS A O 1 ATOM 3697 C CB . HIS A 1 475 ? 44.637 -16.173 34.057 1.00 43.51 ? 475 HIS A CB 1 ATOM 3698 C CG . HIS A 1 475 ? 43.186 -16.308 34.394 1.00 46.53 ? 475 HIS A CG 1 ATOM 3699 N ND1 . HIS A 1 475 ? 42.610 -17.545 34.612 1.00 47.95 ? 475 HIS A ND1 1 ATOM 3700 C CD2 . HIS A 1 475 ? 42.237 -15.353 34.531 1.00 47.88 ? 475 HIS A CD2 1 ATOM 3701 C CE1 . HIS A 1 475 ? 41.335 -17.305 34.862 1.00 47.20 ? 475 HIS A CE1 1 ATOM 3702 N NE2 . HIS A 1 475 ? 41.065 -16.001 34.831 1.00 47.45 ? 475 HIS A NE2 1 ATOM 3703 N N . SER A 1 476 ? 44.794 -18.768 32.546 1.00 44.62 ? 476 SER A N 1 ATOM 3704 C CA . SER A 1 476 ? 44.347 -20.114 32.172 1.00 44.64 ? 476 SER A CA 1 ATOM 3705 C C . SER A 1 476 ? 44.360 -20.334 30.645 1.00 48.13 ? 476 SER A C 1 ATOM 3706 O O . SER A 1 476 ? 43.322 -20.505 29.997 1.00 46.45 ? 476 SER A O 1 ATOM 3707 C CB . SER A 1 476 ? 42.991 -20.437 32.804 1.00 46.99 ? 476 SER A CB 1 ATOM 3708 O OG . SER A 1 476 ? 43.042 -20.274 34.210 1.00 49.93 ? 476 SER A OG 1 ATOM 3709 N N . TYR A 1 477 ? 45.572 -20.279 30.093 1.00 45.97 ? 477 TYR A N 1 ATOM 3710 C CA . TYR A 1 477 ? 45.872 -20.438 28.670 1.00 45.83 ? 477 TYR A CA 1 ATOM 3711 C C . TYR A 1 477 ? 45.667 -21.890 28.213 1.00 49.64 ? 477 TYR A C 1 ATOM 3712 O O . TYR A 1 477 ? 45.813 -22.804 29.021 1.00 48.56 ? 477 TYR A O 1 ATOM 3713 C CB . TYR A 1 477 ? 47.307 -19.935 28.390 1.00 46.13 ? 477 TYR A CB 1 ATOM 3714 C CG . TYR A 1 477 ? 47.429 -18.427 28.470 1.00 47.19 ? 477 TYR A CG 1 ATOM 3715 C CD1 . TYR A 1 477 ? 47.185 -17.631 27.358 1.00 49.15 ? 477 TYR A CD1 1 ATOM 3716 C CD2 . TYR A 1 477 ? 47.746 -17.793 29.668 1.00 48.28 ? 477 TYR A CD2 1 ATOM 3717 C CE1 . TYR A 1 477 ? 47.268 -16.239 27.428 1.00 50.08 ? 477 TYR A CE1 1 ATOM 3718 C CE2 . TYR A 1 477 ? 47.832 -16.401 29.753 1.00 49.24 ? 477 TYR A CE2 1 ATOM 3719 C CZ . TYR A 1 477 ? 47.590 -15.626 28.628 1.00 55.61 ? 477 TYR A CZ 1 ATOM 3720 O OH . TYR A 1 477 ? 47.688 -14.255 28.685 1.00 53.12 ? 477 TYR A OH 1 ATOM 3721 N N . SER A 1 478 ? 45.319 -22.109 26.931 1.00 46.95 ? 478 SER A N 1 ATOM 3722 C CA . SER A 1 478 ? 45.093 -23.474 26.436 1.00 46.82 ? 478 SER A CA 1 ATOM 3723 C C . SER A 1 478 ? 46.348 -24.344 26.554 1.00 50.71 ? 478 SER A C 1 ATOM 3724 O O . SER A 1 478 ? 47.439 -23.847 26.299 1.00 49.68 ? 478 SER A O 1 ATOM 3725 C CB . SER A 1 478 ? 44.536 -23.472 25.018 1.00 49.94 ? 478 SER A CB 1 ATOM 3726 O OG . SER A 1 478 ? 45.478 -23.023 24.060 1.00 61.65 ? 478 SER A OG 1 ATOM 3727 N N . PRO A 1 479 ? 46.237 -25.623 26.988 1.00 49.02 ? 479 PRO A N 1 ATOM 3728 C CA . PRO A 1 479 ? 47.448 -26.458 27.123 1.00 48.73 ? 479 PRO A CA 1 ATOM 3729 C C . PRO A 1 479 ? 48.244 -26.622 25.834 1.00 51.34 ? 479 PRO A C 1 ATOM 3730 O O . PRO A 1 479 ? 49.450 -26.803 25.900 1.00 51.61 ? 479 PRO A O 1 ATOM 3731 C CB . PRO A 1 479 ? 46.918 -27.789 27.673 1.00 50.71 ? 479 PRO A CB 1 ATOM 3732 C CG . PRO A 1 479 ? 45.588 -27.449 28.293 1.00 55.49 ? 479 PRO A CG 1 ATOM 3733 C CD . PRO A 1 479 ? 45.030 -26.380 27.383 1.00 51.16 ? 479 PRO A CD 1 ATOM 3734 N N . GLY A 1 480 ? 47.582 -26.505 24.688 1.00 47.07 ? 480 GLY A N 1 ATOM 3735 C CA . GLY A 1 480 ? 48.230 -26.562 23.382 1.00 46.49 ? 480 GLY A CA 1 ATOM 3736 C C . GLY A 1 480 ? 49.175 -25.390 23.195 1.00 49.18 ? 480 GLY A C 1 ATOM 3737 O O . GLY A 1 480 ? 50.301 -25.559 22.713 1.00 48.48 ? 480 GLY A O 1 ATOM 3738 N N . GLU A 1 481 ? 48.727 -24.197 23.643 1.00 45.08 ? 481 GLU A N 1 ATOM 3739 C CA . GLU A 1 481 ? 49.495 -22.953 23.621 1.00 44.55 ? 481 GLU A CA 1 ATOM 3740 C C . GLU A 1 481 ? 50.643 -23.046 24.615 1.00 48.88 ? 481 GLU A C 1 ATOM 3741 O O . GLU A 1 481 ? 51.801 -22.872 24.219 1.00 49.59 ? 481 GLU A O 1 ATOM 3742 C CB . GLU A 1 481 ? 48.594 -21.729 23.905 1.00 45.54 ? 481 GLU A CB 1 ATOM 3743 C CG . GLU A 1 481 ? 49.248 -20.368 23.695 1.00 52.78 ? 481 GLU A CG 1 ATOM 3744 C CD . GLU A 1 481 ? 49.961 -20.117 22.376 1.00 72.12 ? 481 GLU A CD 1 ATOM 3745 O OE1 . GLU A 1 481 ? 49.568 -20.728 21.354 1.00 70.68 ? 481 GLU A OE1 1 ATOM 3746 O OE2 . GLU A 1 481 ? 50.906 -19.294 22.361 1.00 59.58 ? 481 GLU A OE2 1 ATOM 3747 N N . ILE A 1 482 ? 50.332 -23.377 25.889 1.00 43.72 ? 482 ILE A N 1 ATOM 3748 C CA . ILE A 1 482 ? 51.328 -23.552 26.950 1.00 42.52 ? 482 ILE A CA 1 ATOM 3749 C C . ILE A 1 482 ? 52.475 -24.461 26.479 1.00 47.55 ? 482 ILE A C 1 ATOM 3750 O O . ILE A 1 482 ? 53.638 -24.096 26.645 1.00 47.24 ? 482 ILE A O 1 ATOM 3751 C CB . ILE A 1 482 ? 50.692 -24.044 28.282 1.00 44.31 ? 482 ILE A CB 1 ATOM 3752 C CG1 . ILE A 1 482 ? 49.631 -23.023 28.801 1.00 44.03 ? 482 ILE A CG1 1 ATOM 3753 C CG2 . ILE A 1 482 ? 51.788 -24.319 29.335 1.00 43.93 ? 482 ILE A CG2 1 ATOM 3754 C CD1 . ILE A 1 482 ? 48.891 -23.384 30.070 1.00 45.33 ? 482 ILE A CD1 1 ATOM 3755 N N . ASN A 1 483 ? 52.139 -25.607 25.850 1.00 44.89 ? 483 ASN A N 1 ATOM 3756 C CA . ASN A 1 483 ? 53.110 -26.593 25.375 1.00 45.01 ? 483 ASN A CA 1 ATOM 3757 C C . ASN A 1 483 ? 53.959 -26.107 24.198 1.00 48.45 ? 483 ASN A C 1 ATOM 3758 O O . ASN A 1 483 ? 55.135 -26.461 24.133 1.00 49.31 ? 483 ASN A O 1 ATOM 3759 C CB . ASN A 1 483 ? 52.430 -27.924 25.066 1.00 49.19 ? 483 ASN A CB 1 ATOM 3760 C CG . ASN A 1 483 ? 51.773 -28.596 26.263 1.00 83.47 ? 483 ASN A CG 1 ATOM 3761 O OD1 . ASN A 1 483 ? 51.983 -28.243 27.439 1.00 76.11 ? 483 ASN A OD1 1 ATOM 3762 N ND2 . ASN A 1 483 ? 50.916 -29.567 25.977 1.00 80.50 ? 483 ASN A ND2 1 ATOM 3763 N N . ARG A 1 484 ? 53.394 -25.281 23.295 1.00 43.28 ? 484 ARG A N 1 ATOM 3764 C CA . ARG A 1 484 ? 54.148 -24.716 22.171 1.00 42.07 ? 484 ARG A CA 1 ATOM 3765 C C . ARG A 1 484 ? 55.242 -23.795 22.742 1.00 46.31 ? 484 ARG A C 1 ATOM 3766 O O . ARG A 1 484 ? 56.414 -23.935 22.384 1.00 45.77 ? 484 ARG A O 1 ATOM 3767 C CB . ARG A 1 484 ? 53.208 -23.965 21.204 1.00 39.62 ? 484 ARG A CB 1 ATOM 3768 C CG . ARG A 1 484 ? 53.905 -23.382 19.969 1.00 39.83 ? 484 ARG A CG 1 ATOM 3769 C CD . ARG A 1 484 ? 52.957 -23.056 18.820 1.00 32.94 ? 484 ARG A CD 1 ATOM 3770 N NE . ARG A 1 484 ? 52.088 -21.919 19.105 1.00 36.74 ? 484 ARG A NE 1 ATOM 3771 C CZ . ARG A 1 484 ? 51.337 -21.307 18.197 1.00 56.48 ? 484 ARG A CZ 1 ATOM 3772 N NH1 . ARG A 1 484 ? 51.358 -21.705 16.929 1.00 46.79 ? 484 ARG A NH1 1 ATOM 3773 N NH2 . ARG A 1 484 ? 50.562 -20.291 18.546 1.00 47.69 ? 484 ARG A NH2 1 ATOM 3774 N N . VAL A 1 485 ? 54.857 -22.915 23.688 1.00 43.46 ? 485 VAL A N 1 ATOM 3775 C CA . VAL A 1 485 ? 55.754 -21.981 24.377 1.00 43.26 ? 485 VAL A CA 1 ATOM 3776 C C . VAL A 1 485 ? 56.829 -22.768 25.124 1.00 48.84 ? 485 VAL A C 1 ATOM 3777 O O . VAL A 1 485 ? 58.005 -22.584 24.830 1.00 48.55 ? 485 VAL A O 1 ATOM 3778 C CB . VAL A 1 485 ? 54.993 -20.956 25.278 1.00 46.81 ? 485 VAL A CB 1 ATOM 3779 C CG1 . VAL A 1 485 ? 55.954 -19.975 25.950 1.00 46.23 ? 485 VAL A CG1 1 ATOM 3780 C CG2 . VAL A 1 485 ? 53.930 -20.196 24.479 1.00 46.58 ? 485 VAL A CG2 1 ATOM 3781 N N . ALA A 1 486 ? 56.422 -23.696 26.017 1.00 48.07 ? 486 ALA A N 1 ATOM 3782 C CA . ALA A 1 486 ? 57.316 -24.548 26.812 1.00 49.38 ? 486 ALA A CA 1 ATOM 3783 C C . ALA A 1 486 ? 58.377 -25.247 25.954 1.00 56.05 ? 486 ALA A C 1 ATOM 3784 O O . ALA A 1 486 ? 59.564 -25.108 26.246 1.00 56.44 ? 486 ALA A O 1 ATOM 3785 C CB . ALA A 1 486 ? 56.514 -25.568 27.600 1.00 50.19 ? 486 ALA A CB 1 ATOM 3786 N N . SER A 1 487 ? 57.955 -25.927 24.865 1.00 53.81 ? 487 SER A N 1 ATOM 3787 C CA . SER A 1 487 ? 58.831 -26.637 23.924 1.00 54.54 ? 487 SER A CA 1 ATOM 3788 C C . SER A 1 487 ? 59.801 -25.695 23.198 1.00 60.35 ? 487 SER A C 1 ATOM 3789 O O . SER A 1 487 ? 60.927 -26.104 22.915 1.00 60.97 ? 487 SER A O 1 ATOM 3790 C CB . SER A 1 487 ? 58.006 -27.430 22.912 1.00 58.51 ? 487 SER A CB 1 ATOM 3791 O OG . SER A 1 487 ? 58.564 -28.714 22.685 1.00 67.68 ? 487 SER A OG 1 ATOM 3792 N N . CYS A 1 488 ? 59.355 -24.449 22.885 1.00 56.87 ? 488 CYS A N 1 ATOM 3793 C CA . CYS A 1 488 ? 60.150 -23.390 22.253 1.00 56.41 ? 488 CYS A CA 1 ATOM 3794 C C . CYS A 1 488 ? 61.235 -22.918 23.223 1.00 55.37 ? 488 CYS A C 1 ATOM 3795 O O . CYS A 1 488 ? 62.392 -22.778 22.820 1.00 54.89 ? 488 CYS A O 1 ATOM 3796 C CB . CYS A 1 488 ? 59.251 -22.238 21.815 1.00 57.99 ? 488 CYS A CB 1 ATOM 3797 S SG . CYS A 1 488 ? 60.130 -20.701 21.415 1.00 62.71 ? 488 CYS A SG 1 ATOM 3798 N N . LEU A 1 489 ? 60.859 -22.714 24.510 1.00 48.59 ? 489 LEU A N 1 ATOM 3799 C CA . LEU A 1 489 ? 61.760 -22.304 25.594 1.00 47.04 ? 489 LEU A CA 1 ATOM 3800 C C . LEU A 1 489 ? 62.850 -23.345 25.773 1.00 51.15 ? 489 LEU A C 1 ATOM 3801 O O . LEU A 1 489 ? 63.987 -23.004 26.106 1.00 51.25 ? 489 LEU A O 1 ATOM 3802 C CB . LEU A 1 489 ? 61.008 -22.106 26.928 1.00 46.37 ? 489 LEU A CB 1 ATOM 3803 C CG . LEU A 1 489 ? 59.849 -21.102 27.010 1.00 49.75 ? 489 LEU A CG 1 ATOM 3804 C CD1 . LEU A 1 489 ? 59.625 -20.668 28.427 1.00 49.34 ? 489 LEU A CD1 1 ATOM 3805 C CD2 . LEU A 1 489 ? 60.096 -19.875 26.168 1.00 53.02 ? 489 LEU A CD2 1 ATOM 3806 N N . ARG A 1 490 ? 62.493 -24.622 25.541 1.00 47.16 ? 490 ARG A N 1 ATOM 3807 C CA . ARG A 1 490 ? 63.399 -25.769 25.601 1.00 46.48 ? 490 ARG A CA 1 ATOM 3808 C C . ARG A 1 490 ? 64.366 -25.753 24.399 1.00 49.01 ? 490 ARG A C 1 ATOM 3809 O O . ARG A 1 490 ? 65.572 -25.947 24.574 1.00 48.83 ? 490 ARG A O 1 ATOM 3810 C CB . ARG A 1 490 ? 62.606 -27.091 25.658 1.00 45.05 ? 490 ARG A CB 1 ATOM 3811 C CG . ARG A 1 490 ? 61.860 -27.318 26.975 1.00 51.29 ? 490 ARG A CG 1 ATOM 3812 C CD . ARG A 1 490 ? 61.236 -28.702 27.058 1.00 57.38 ? 490 ARG A CD 1 ATOM 3813 N NE . ARG A 1 490 ? 59.802 -28.650 27.341 1.00 61.70 ? 490 ARG A NE 1 ATOM 3814 C CZ . ARG A 1 490 ? 58.869 -29.294 26.645 1.00 75.30 ? 490 ARG A CZ 1 ATOM 3815 N NH1 . ARG A 1 490 ? 57.589 -29.181 26.978 1.00 66.22 ? 490 ARG A NH1 1 ATOM 3816 N NH2 . ARG A 1 490 ? 59.207 -30.055 25.608 1.00 56.32 ? 490 ARG A NH2 1 ATOM 3817 N N . LYS A 1 491 ? 63.829 -25.500 23.196 1.00 44.66 ? 491 LYS A N 1 ATOM 3818 C CA . LYS A 1 491 ? 64.549 -25.454 21.922 1.00 44.49 ? 491 LYS A CA 1 ATOM 3819 C C . LYS A 1 491 ? 65.672 -24.411 21.933 1.00 50.37 ? 491 LYS A C 1 ATOM 3820 O O . LYS A 1 491 ? 66.837 -24.770 21.754 1.00 50.07 ? 491 LYS A O 1 ATOM 3821 C CB . LYS A 1 491 ? 63.562 -25.226 20.758 1.00 45.05 ? 491 LYS A CB 1 ATOM 3822 C CG . LYS A 1 491 ? 64.220 -25.119 19.387 1.00 43.27 ? 491 LYS A CG 1 ATOM 3823 C CD . LYS A 1 491 ? 63.231 -25.251 18.225 1.00 46.23 ? 491 LYS A CD 1 ATOM 3824 C CE . LYS A 1 491 ? 62.412 -24.013 17.933 1.00 39.76 ? 491 LYS A CE 1 ATOM 3825 N NZ . LYS A 1 491 ? 61.031 -24.118 18.474 1.00 40.81 ? 491 LYS A NZ 1 ATOM 3826 N N . LEU A 1 492 ? 65.318 -23.143 22.205 1.00 47.39 ? 492 LEU A N 1 ATOM 3827 C CA . LEU A 1 492 ? 66.242 -22.003 22.247 1.00 46.76 ? 492 LEU A CA 1 ATOM 3828 C C . LEU A 1 492 ? 67.106 -21.913 23.523 1.00 51.08 ? 492 LEU A C 1 ATOM 3829 O O . LEU A 1 492 ? 68.179 -21.314 23.494 1.00 49.95 ? 492 LEU A O 1 ATOM 3830 C CB . LEU A 1 492 ? 65.462 -20.696 22.028 1.00 46.20 ? 492 LEU A CB 1 ATOM 3831 C CG . LEU A 1 492 ? 64.803 -20.517 20.659 1.00 49.30 ? 492 LEU A CG 1 ATOM 3832 C CD1 . LEU A 1 492 ? 63.629 -19.579 20.753 1.00 49.55 ? 492 LEU A CD1 1 ATOM 3833 C CD2 . LEU A 1 492 ? 65.796 -20.030 19.626 1.00 49.62 ? 492 LEU A CD2 1 ATOM 3834 N N . GLY A 1 493 ? 66.636 -22.509 24.614 1.00 48.99 ? 493 GLY A N 1 ATOM 3835 C CA . GLY A 1 493 ? 67.345 -22.493 25.889 1.00 48.72 ? 493 GLY A CA 1 ATOM 3836 C C . GLY A 1 493 ? 66.983 -21.275 26.704 1.00 52.35 ? 493 GLY A C 1 ATOM 3837 O O . GLY A 1 493 ? 67.844 -20.664 27.339 1.00 52.84 ? 493 GLY A O 1 ATOM 3838 N N . VAL A 1 494 ? 65.704 -20.899 26.643 1.00 47.86 ? 494 VAL A N 1 ATOM 3839 C CA . VAL A 1 494 ? 65.132 -19.759 27.345 1.00 47.41 ? 494 VAL A CA 1 ATOM 3840 C C . VAL A 1 494 ? 64.792 -20.211 28.772 1.00 50.98 ? 494 VAL A C 1 ATOM 3841 O O . VAL A 1 494 ? 64.216 -21.299 28.937 1.00 50.61 ? 494 VAL A O 1 ATOM 3842 C CB . VAL A 1 494 ? 63.883 -19.201 26.582 1.00 51.24 ? 494 VAL A CB 1 ATOM 3843 C CG1 . VAL A 1 494 ? 63.248 -18.013 27.308 1.00 51.36 ? 494 VAL A CG1 1 ATOM 3844 C CG2 . VAL A 1 494 ? 64.229 -18.815 25.147 1.00 51.00 ? 494 VAL A CG2 1 ATOM 3845 N N . PRO A 1 495 ? 65.119 -19.409 29.820 1.00 47.50 ? 495 PRO A N 1 ATOM 3846 C CA . PRO A 1 495 ? 64.748 -19.816 31.192 1.00 46.86 ? 495 PRO A CA 1 ATOM 3847 C C . PRO A 1 495 ? 63.246 -20.115 31.306 1.00 48.87 ? 495 PRO A C 1 ATOM 3848 O O . PRO A 1 495 ? 62.461 -19.489 30.589 1.00 47.41 ? 495 PRO A O 1 ATOM 3849 C CB . PRO A 1 495 ? 65.165 -18.614 32.042 1.00 48.47 ? 495 PRO A CB 1 ATOM 3850 C CG . PRO A 1 495 ? 66.242 -17.951 31.248 1.00 53.23 ? 495 PRO A CG 1 ATOM 3851 C CD . PRO A 1 495 ? 65.809 -18.101 29.825 1.00 48.89 ? 495 PRO A CD 1 ATOM 3852 N N . PRO A 1 496 ? 62.822 -21.113 32.116 1.00 45.41 ? 496 PRO A N 1 ATOM 3853 C CA . PRO A 1 496 ? 61.383 -21.438 32.183 1.00 45.21 ? 496 PRO A CA 1 ATOM 3854 C C . PRO A 1 496 ? 60.509 -20.304 32.722 1.00 50.48 ? 496 PRO A C 1 ATOM 3855 O O . PRO A 1 496 ? 61.008 -19.422 33.418 1.00 50.91 ? 496 PRO A O 1 ATOM 3856 C CB . PRO A 1 496 ? 61.335 -22.686 33.077 1.00 46.58 ? 496 PRO A CB 1 ATOM 3857 C CG . PRO A 1 496 ? 62.568 -22.633 33.881 1.00 51.00 ? 496 PRO A CG 1 ATOM 3858 C CD . PRO A 1 496 ? 63.610 -21.992 33.003 1.00 46.81 ? 496 PRO A CD 1 ATOM 3859 N N . LEU A 1 497 ? 59.201 -20.338 32.394 1.00 47.03 ? 497 LEU A N 1 ATOM 3860 C CA . LEU A 1 497 ? 58.182 -19.360 32.782 1.00 46.66 ? 497 LEU A CA 1 ATOM 3861 C C . LEU A 1 497 ? 58.201 -19.008 34.270 1.00 50.78 ? 497 LEU A C 1 ATOM 3862 O O . LEU A 1 497 ? 58.014 -17.836 34.601 1.00 51.56 ? 497 LEU A O 1 ATOM 3863 C CB . LEU A 1 497 ? 56.774 -19.812 32.333 1.00 46.87 ? 497 LEU A CB 1 ATOM 3864 C CG . LEU A 1 497 ? 56.568 -20.032 30.807 1.00 51.91 ? 497 LEU A CG 1 ATOM 3865 C CD1 . LEU A 1 497 ? 55.388 -20.952 30.532 1.00 52.02 ? 497 LEU A CD1 1 ATOM 3866 C CD2 . LEU A 1 497 ? 56.391 -18.708 30.043 1.00 54.03 ? 497 LEU A CD2 1 ATOM 3867 N N . ARG A 1 498 ? 58.478 -19.986 35.164 1.00 46.54 ? 498 ARG A N 1 ATOM 3868 C CA . ARG A 1 498 ? 58.566 -19.708 36.607 1.00 46.21 ? 498 ARG A CA 1 ATOM 3869 C C . ARG A 1 498 ? 59.688 -18.699 36.901 1.00 49.54 ? 498 ARG A C 1 ATOM 3870 O O . ARG A 1 498 ? 59.509 -17.831 37.761 1.00 49.65 ? 498 ARG A O 1 ATOM 3871 C CB . ARG A 1 498 ? 58.703 -20.989 37.465 1.00 46.66 ? 498 ARG A CB 1 ATOM 3872 C CG . ARG A 1 498 ? 59.900 -21.863 37.126 1.00 56.30 ? 498 ARG A CG 1 ATOM 3873 C CD . ARG A 1 498 ? 60.343 -22.741 38.275 1.00 65.98 ? 498 ARG A CD 1 ATOM 3874 N NE . ARG A 1 498 ? 61.515 -23.526 37.887 1.00 78.12 ? 498 ARG A NE 1 ATOM 3875 C CZ . ARG A 1 498 ? 62.767 -23.220 38.215 1.00 90.74 ? 498 ARG A CZ 1 ATOM 3876 N NH1 . ARG A 1 498 ? 63.022 -22.158 38.973 1.00 70.67 ? 498 ARG A NH1 1 ATOM 3877 N NH2 . ARG A 1 498 ? 63.771 -23.984 37.803 1.00 79.24 ? 498 ARG A NH2 1 ATOM 3878 N N . VAL A 1 499 ? 60.814 -18.780 36.140 1.00 44.64 ? 499 VAL A N 1 ATOM 3879 C CA . VAL A 1 499 ? 61.957 -17.860 36.253 1.00 43.63 ? 499 VAL A CA 1 ATOM 3880 C C . VAL A 1 499 ? 61.490 -16.431 35.840 1.00 47.08 ? 499 VAL A C 1 ATOM 3881 O O . VAL A 1 499 ? 61.806 -15.453 36.533 1.00 46.34 ? 499 VAL A O 1 ATOM 3882 C CB . VAL A 1 499 ? 63.189 -18.349 35.435 1.00 45.86 ? 499 VAL A CB 1 ATOM 3883 C CG1 . VAL A 1 499 ? 64.320 -17.330 35.453 1.00 45.29 ? 499 VAL A CG1 1 ATOM 3884 C CG2 . VAL A 1 499 ? 63.682 -19.684 35.940 1.00 45.22 ? 499 VAL A CG2 1 ATOM 3885 N N . TRP A 1 500 ? 60.697 -16.341 34.745 1.00 41.32 ? 500 TRP A N 1 ATOM 3886 C CA . TRP A 1 500 ? 60.172 -15.085 34.235 1.00 40.33 ? 500 TRP A CA 1 ATOM 3887 C C . TRP A 1 500 ? 59.151 -14.443 35.169 1.00 47.39 ? 500 TRP A C 1 ATOM 3888 O O . TRP A 1 500 ? 59.150 -13.214 35.275 1.00 48.87 ? 500 TRP A O 1 ATOM 3889 C CB . TRP A 1 500 ? 59.635 -15.241 32.813 1.00 38.18 ? 500 TRP A CB 1 ATOM 3890 C CG . TRP A 1 500 ? 60.719 -15.563 31.823 1.00 38.46 ? 500 TRP A CG 1 ATOM 3891 C CD1 . TRP A 1 500 ? 61.001 -16.785 31.285 1.00 41.16 ? 500 TRP A CD1 1 ATOM 3892 C CD2 . TRP A 1 500 ? 61.724 -14.663 31.326 1.00 37.89 ? 500 TRP A CD2 1 ATOM 3893 N NE1 . TRP A 1 500 ? 62.098 -16.696 30.454 1.00 40.37 ? 500 TRP A NE1 1 ATOM 3894 C CE2 . TRP A 1 500 ? 62.560 -15.404 30.460 1.00 41.62 ? 500 TRP A CE2 1 ATOM 3895 C CE3 . TRP A 1 500 ? 61.989 -13.296 31.517 1.00 38.72 ? 500 TRP A CE3 1 ATOM 3896 C CZ2 . TRP A 1 500 ? 63.637 -14.823 29.784 1.00 40.79 ? 500 TRP A CZ2 1 ATOM 3897 C CZ3 . TRP A 1 500 ? 63.055 -12.726 30.848 1.00 40.07 ? 500 TRP A CZ3 1 ATOM 3898 C CH2 . TRP A 1 500 ? 63.862 -13.482 29.990 1.00 40.73 ? 500 TRP A CH2 1 ATOM 3899 N N . ARG A 1 501 ? 58.318 -15.247 35.876 1.00 43.44 ? 501 ARG A N 1 ATOM 3900 C CA . ARG A 1 501 ? 57.350 -14.733 36.867 1.00 43.15 ? 501 ARG A CA 1 ATOM 3901 C C . ARG A 1 501 ? 58.120 -14.101 38.052 1.00 48.82 ? 501 ARG A C 1 ATOM 3902 O O . ARG A 1 501 ? 57.720 -13.053 38.565 1.00 48.84 ? 501 ARG A O 1 ATOM 3903 C CB . ARG A 1 501 ? 56.407 -15.859 37.353 1.00 41.29 ? 501 ARG A CB 1 ATOM 3904 C CG . ARG A 1 501 ? 55.450 -15.474 38.492 1.00 45.08 ? 501 ARG A CG 1 ATOM 3905 C CD . ARG A 1 501 ? 54.484 -16.591 38.897 1.00 53.39 ? 501 ARG A CD 1 ATOM 3906 N NE . ARG A 1 501 ? 53.701 -17.134 37.771 1.00 71.71 ? 501 ARG A NE 1 ATOM 3907 C CZ . ARG A 1 501 ? 52.665 -16.530 37.183 1.00 89.66 ? 501 ARG A CZ 1 ATOM 3908 N NH1 . ARG A 1 501 ? 52.247 -15.344 37.610 1.00 78.35 ? 501 ARG A NH1 1 ATOM 3909 N NH2 . ARG A 1 501 ? 52.039 -17.110 36.167 1.00 73.79 ? 501 ARG A NH2 1 ATOM 3910 N N . HIS A 1 502 ? 59.236 -14.737 38.462 1.00 45.84 ? 502 HIS A N 1 ATOM 3911 C CA . HIS A 1 502 ? 60.088 -14.262 39.547 1.00 45.48 ? 502 HIS A CA 1 ATOM 3912 C C . HIS A 1 502 ? 60.767 -12.950 39.133 1.00 48.72 ? 502 HIS A C 1 ATOM 3913 O O . HIS A 1 502 ? 60.817 -11.993 39.918 1.00 48.76 ? 502 HIS A O 1 ATOM 3914 C CB . HIS A 1 502 ? 61.115 -15.339 39.924 1.00 46.59 ? 502 HIS A CB 1 ATOM 3915 C CG . HIS A 1 502 ? 61.991 -14.930 41.054 1.00 50.95 ? 502 HIS A CG 1 ATOM 3916 N ND1 . HIS A 1 502 ? 61.512 -14.871 42.353 1.00 53.56 ? 502 HIS A ND1 1 ATOM 3917 C CD2 . HIS A 1 502 ? 63.271 -14.502 41.036 1.00 53.63 ? 502 HIS A CD2 1 ATOM 3918 C CE1 . HIS A 1 502 ? 62.520 -14.428 43.085 1.00 53.41 ? 502 HIS A CE1 1 ATOM 3919 N NE2 . HIS A 1 502 ? 63.603 -14.196 42.337 1.00 53.81 ? 502 HIS A NE2 1 ATOM 3920 N N . ARG A 1 503 ? 61.235 -12.896 37.877 1.00 43.95 ? 503 ARG A N 1 ATOM 3921 C CA . ARG A 1 503 ? 61.874 -11.726 37.287 1.00 42.98 ? 503 ARG A CA 1 ATOM 3922 C C . ARG A 1 503 ? 60.873 -10.564 37.096 1.00 46.86 ? 503 ARG A C 1 ATOM 3923 O O . ARG A 1 503 ? 61.245 -9.415 37.304 1.00 46.25 ? 503 ARG A O 1 ATOM 3924 C CB . ARG A 1 503 ? 62.548 -12.100 35.955 1.00 40.60 ? 503 ARG A CB 1 ATOM 3925 C CG . ARG A 1 503 ? 63.814 -12.919 36.111 1.00 41.46 ? 503 ARG A CG 1 ATOM 3926 C CD . ARG A 1 503 ? 64.414 -13.205 34.761 1.00 45.30 ? 503 ARG A CD 1 ATOM 3927 N NE . ARG A 1 503 ? 65.729 -13.844 34.857 1.00 45.01 ? 503 ARG A NE 1 ATOM 3928 C CZ . ARG A 1 503 ? 66.228 -14.657 33.932 1.00 54.48 ? 503 ARG A CZ 1 ATOM 3929 N NH1 . ARG A 1 503 ? 65.520 -14.960 32.855 1.00 41.78 ? 503 ARG A NH1 1 ATOM 3930 N NH2 . ARG A 1 503 ? 67.429 -15.195 34.091 1.00 44.27 ? 503 ARG A NH2 1 ATOM 3931 N N . ALA A 1 504 ? 59.612 -10.865 36.724 1.00 44.09 ? 504 ALA A N 1 ATOM 3932 C CA . ALA A 1 504 ? 58.561 -9.857 36.523 1.00 44.34 ? 504 ALA A CA 1 ATOM 3933 C C . ALA A 1 504 ? 58.144 -9.146 37.816 1.00 48.22 ? 504 ALA A C 1 ATOM 3934 O O . ALA A 1 504 ? 57.746 -7.979 37.769 1.00 47.19 ? 504 ALA A O 1 ATOM 3935 C CB . ALA A 1 504 ? 57.353 -10.477 35.850 1.00 44.90 ? 504 ALA A CB 1 ATOM 3936 N N . ARG A 1 505 ? 58.232 -9.857 38.961 1.00 44.92 ? 505 ARG A N 1 ATOM 3937 C CA . ARG A 1 505 ? 57.935 -9.325 40.292 1.00 44.27 ? 505 ARG A CA 1 ATOM 3938 C C . ARG A 1 505 ? 58.943 -8.207 40.591 1.00 46.22 ? 505 ARG A C 1 ATOM 3939 O O . ARG A 1 505 ? 58.545 -7.131 41.025 1.00 46.14 ? 505 ARG A O 1 ATOM 3940 C CB . ARG A 1 505 ? 58.030 -10.433 41.348 1.00 45.26 ? 505 ARG A CB 1 ATOM 3941 C CG . ARG A 1 505 ? 56.861 -11.398 41.369 1.00 51.59 ? 505 ARG A CG 1 ATOM 3942 C CD . ARG A 1 505 ? 57.078 -12.487 42.400 1.00 60.28 ? 505 ARG A CD 1 ATOM 3943 N NE . ARG A 1 505 ? 55.865 -13.284 42.574 1.00 75.70 ? 505 ARG A NE 1 ATOM 3944 C CZ . ARG A 1 505 ? 55.749 -14.567 42.245 1.00 97.93 ? 505 ARG A CZ 1 ATOM 3945 N NH1 . ARG A 1 505 ? 56.790 -15.232 41.751 1.00 88.55 ? 505 ARG A NH1 1 ATOM 3946 N NH2 . ARG A 1 505 ? 54.598 -15.202 42.425 1.00 87.15 ? 505 ARG A NH2 1 ATOM 3947 N N . SER A 1 506 ? 60.234 -8.452 40.282 1.00 41.40 ? 506 SER A N 1 ATOM 3948 C CA . SER A 1 506 ? 61.339 -7.504 40.419 1.00 40.37 ? 506 SER A CA 1 ATOM 3949 C C . SER A 1 506 ? 61.139 -6.308 39.491 1.00 46.36 ? 506 SER A C 1 ATOM 3950 O O . SER A 1 506 ? 61.204 -5.173 39.956 1.00 46.77 ? 506 SER A O 1 ATOM 3951 C CB . SER A 1 506 ? 62.668 -8.186 40.119 1.00 40.36 ? 506 SER A CB 1 ATOM 3952 O OG . SER A 1 506 ? 63.685 -7.228 39.895 1.00 45.54 ? 506 SER A OG 1 ATOM 3953 N N . VAL A 1 507 ? 60.887 -6.558 38.188 1.00 43.78 ? 507 VAL A N 1 ATOM 3954 C CA . VAL A 1 507 ? 60.642 -5.509 37.188 1.00 43.62 ? 507 VAL A CA 1 ATOM 3955 C C . VAL A 1 507 ? 59.487 -4.605 37.673 1.00 48.16 ? 507 VAL A C 1 ATOM 3956 O O . VAL A 1 507 ? 59.653 -3.388 37.747 1.00 47.33 ? 507 VAL A O 1 ATOM 3957 C CB . VAL A 1 507 ? 60.393 -6.091 35.772 1.00 46.81 ? 507 VAL A CB 1 ATOM 3958 C CG1 . VAL A 1 507 ? 60.122 -4.982 34.763 1.00 46.64 ? 507 VAL A CG1 1 ATOM 3959 C CG2 . VAL A 1 507 ? 61.569 -6.948 35.316 1.00 46.31 ? 507 VAL A CG2 1 ATOM 3960 N N . ARG A 1 508 ? 58.363 -5.226 38.081 1.00 45.21 ? 508 ARG A N 1 ATOM 3961 C CA . ARG A 1 508 ? 57.187 -4.559 38.622 1.00 44.60 ? 508 ARG A CA 1 ATOM 3962 C C . ARG A 1 508 ? 57.520 -3.758 39.867 1.00 48.03 ? 508 ARG A C 1 ATOM 3963 O O . ARG A 1 508 ? 57.032 -2.641 39.992 1.00 48.99 ? 508 ARG A O 1 ATOM 3964 C CB . ARG A 1 508 ? 56.080 -5.574 38.945 1.00 44.33 ? 508 ARG A CB 1 ATOM 3965 C CG . ARG A 1 508 ? 54.758 -4.899 39.245 1.00 53.28 ? 508 ARG A CG 1 ATOM 3966 C CD . ARG A 1 508 ? 53.789 -5.833 39.907 1.00 60.94 ? 508 ARG A CD 1 ATOM 3967 N NE . ARG A 1 508 ? 52.712 -5.094 40.557 1.00 68.70 ? 508 ARG A NE 1 ATOM 3968 C CZ . ARG A 1 508 ? 52.732 -4.694 41.824 1.00 84.23 ? 508 ARG A CZ 1 ATOM 3969 N NH1 . ARG A 1 508 ? 53.782 -4.957 42.596 1.00 67.58 ? 508 ARG A NH1 1 ATOM 3970 N NH2 . ARG A 1 508 ? 51.708 -4.018 42.327 1.00 73.96 ? 508 ARG A NH2 1 ATOM 3971 N N . ALA A 1 509 ? 58.315 -4.320 40.794 1.00 43.75 ? 509 ALA A N 1 ATOM 3972 C CA . ALA A 1 509 ? 58.674 -3.613 42.024 1.00 44.03 ? 509 ALA A CA 1 ATOM 3973 C C . ALA A 1 509 ? 59.528 -2.375 41.715 1.00 49.08 ? 509 ALA A C 1 ATOM 3974 O O . ALA A 1 509 ? 59.272 -1.308 42.283 1.00 48.25 ? 509 ALA A O 1 ATOM 3975 C CB . ALA A 1 509 ? 59.397 -4.544 42.983 1.00 44.87 ? 509 ALA A CB 1 ATOM 3976 N N . ARG A 1 510 ? 60.501 -2.519 40.774 1.00 46.74 ? 510 ARG A N 1 ATOM 3977 C CA . ARG A 1 510 ? 61.395 -1.468 40.280 1.00 46.74 ? 510 ARG A CA 1 ATOM 3978 C C . ARG A 1 510 ? 60.591 -0.373 39.589 1.00 53.69 ? 510 ARG A C 1 ATOM 3979 O O . ARG A 1 510 ? 60.928 0.801 39.737 1.00 54.53 ? 510 ARG A O 1 ATOM 3980 C CB . ARG A 1 510 ? 62.402 -2.045 39.267 1.00 45.36 ? 510 ARG A CB 1 ATOM 3981 C CG . ARG A 1 510 ? 63.595 -2.755 39.872 1.00 48.71 ? 510 ARG A CG 1 ATOM 3982 C CD . ARG A 1 510 ? 64.115 -3.844 38.965 1.00 49.41 ? 510 ARG A CD 1 ATOM 3983 N NE . ARG A 1 510 ? 65.111 -3.371 38.000 1.00 46.94 ? 510 ARG A NE 1 ATOM 3984 C CZ . ARG A 1 510 ? 65.731 -4.164 37.127 1.00 63.14 ? 510 ARG A CZ 1 ATOM 3985 N NH1 . ARG A 1 510 ? 65.455 -5.464 37.085 1.00 53.16 ? 510 ARG A NH1 1 ATOM 3986 N NH2 . ARG A 1 510 ? 66.629 -3.664 36.289 1.00 51.28 ? 510 ARG A NH2 1 ATOM 3987 N N . LEU A 1 511 ? 59.550 -0.763 38.813 1.00 52.05 ? 511 LEU A N 1 ATOM 3988 C CA . LEU A 1 511 ? 58.679 0.145 38.055 1.00 52.72 ? 511 LEU A CA 1 ATOM 3989 C C . LEU A 1 511 ? 57.762 0.978 38.938 1.00 58.42 ? 511 LEU A C 1 ATOM 3990 O O . LEU A 1 511 ? 57.527 2.143 38.628 1.00 58.75 ? 511 LEU A O 1 ATOM 3991 C CB . LEU A 1 511 ? 57.870 -0.594 36.962 1.00 52.78 ? 511 LEU A CB 1 ATOM 3992 C CG . LEU A 1 511 ? 58.590 -0.886 35.628 1.00 57.40 ? 511 LEU A CG 1 ATOM 3993 C CD1 . LEU A 1 511 ? 57.838 -1.903 34.810 1.00 57.09 ? 511 LEU A CD1 1 ATOM 3994 C CD2 . LEU A 1 511 ? 58.768 0.364 34.796 1.00 61.29 ? 511 LEU A CD2 1 ATOM 3995 N N . LEU A 1 512 ? 57.248 0.406 40.034 1.00 56.42 ? 512 LEU A N 1 ATOM 3996 C CA . LEU A 1 512 ? 56.383 1.171 40.935 1.00 56.96 ? 512 LEU A CA 1 ATOM 3997 C C . LEU A 1 512 ? 57.187 2.283 41.618 1.00 62.38 ? 512 LEU A C 1 ATOM 3998 O O . LEU A 1 512 ? 56.733 3.432 41.635 1.00 62.45 ? 512 LEU A O 1 ATOM 3999 C CB . LEU A 1 512 ? 55.676 0.278 41.971 1.00 56.82 ? 512 LEU A CB 1 ATOM 4000 C CG . LEU A 1 512 ? 54.707 -0.793 41.453 1.00 61.07 ? 512 LEU A CG 1 ATOM 4001 C CD1 . LEU A 1 512 ? 54.223 -1.637 42.588 1.00 60.98 ? 512 LEU A CD1 1 ATOM 4002 C CD2 . LEU A 1 512 ? 53.506 -0.181 40.709 1.00 63.14 ? 512 LEU A CD2 1 ATOM 4003 N N . SER A 1 513 ? 58.418 1.944 42.089 1.00 59.21 ? 513 SER A N 1 ATOM 4004 C CA . SER A 1 513 ? 59.386 2.830 42.753 1.00 59.45 ? 513 SER A CA 1 ATOM 4005 C C . SER A 1 513 ? 59.711 4.082 41.923 1.00 68.39 ? 513 SER A C 1 ATOM 4006 O O . SER A 1 513 ? 59.902 5.153 42.502 1.00 69.03 ? 513 SER A O 1 ATOM 4007 C CB . SER A 1 513 ? 60.670 2.071 43.081 1.00 60.24 ? 513 SER A CB 1 ATOM 4008 O OG . SER A 1 513 ? 60.435 0.959 43.931 1.00 61.25 ? 513 SER A OG 1 ATOM 4009 N N . GLN A 1 514 ? 59.746 3.954 40.571 1.00 67.33 ? 514 GLN A N 1 ATOM 4010 C CA . GLN A 1 514 ? 60.021 5.052 39.621 1.00 67.73 ? 514 GLN A CA 1 ATOM 4011 C C . GLN A 1 514 ? 58.872 6.073 39.539 1.00 71.76 ? 514 GLN A C 1 ATOM 4012 O O . GLN A 1 514 ? 59.111 7.238 39.201 1.00 71.46 ? 514 GLN A O 1 ATOM 4013 C CB . GLN A 1 514 ? 60.334 4.503 38.213 1.00 69.10 ? 514 GLN A CB 1 ATOM 4014 C CG . GLN A 1 514 ? 61.605 3.652 38.120 1.00 88.17 ? 514 GLN A CG 1 ATOM 4015 C CD . GLN A 1 514 ? 62.807 4.406 37.592 1.00 112.86 ? 514 GLN A CD 1 ATOM 4016 O OE1 . GLN A 1 514 ? 62.737 5.123 36.590 1.00 109.91 ? 514 GLN A OE1 1 ATOM 4017 N NE2 . GLN A 1 514 ? 63.956 4.215 38.223 1.00 106.33 ? 514 GLN A NE2 1 ATOM 4018 N N . GLY A 1 515 ? 57.646 5.617 39.816 1.00 68.02 ? 515 GLY A N 1 ATOM 4019 C CA . GLY A 1 515 ? 56.438 6.436 39.785 1.00 67.71 ? 515 GLY A CA 1 ATOM 4020 C C . GLY A 1 515 ? 56.039 6.885 38.397 1.00 72.27 ? 515 GLY A C 1 ATOM 4021 O O . GLY A 1 515 ? 56.744 6.613 37.417 1.00 71.89 ? 515 GLY A O 1 ATOM 4022 N N . GLY A 1 516 ? 54.899 7.567 38.325 1.00 69.50 ? 516 GLY A N 1 ATOM 4023 C CA . GLY A 1 516 ? 54.342 8.096 37.082 1.00 69.51 ? 516 GLY A CA 1 ATOM 4024 C C . GLY A 1 516 ? 53.853 7.037 36.116 1.00 73.28 ? 516 GLY A C 1 ATOM 4025 O O . GLY A 1 516 ? 53.090 6.147 36.508 1.00 72.99 ? 516 GLY A O 1 ATOM 4026 N N . ARG A 1 517 ? 54.288 7.139 34.837 1.00 69.30 ? 517 ARG A N 1 ATOM 4027 C CA . ARG A 1 517 ? 53.927 6.193 33.772 1.00 68.35 ? 517 ARG A CA 1 ATOM 4028 C C . ARG A 1 517 ? 54.569 4.827 34.026 1.00 71.95 ? 517 ARG A C 1 ATOM 4029 O O . ARG A 1 517 ? 53.968 3.816 33.687 1.00 71.67 ? 517 ARG A O 1 ATOM 4030 C CB . ARG A 1 517 ? 54.290 6.733 32.376 1.00 66.28 ? 517 ARG A CB 1 ATOM 4031 C CG . ARG A 1 517 ? 53.412 7.899 31.900 1.00 71.53 ? 517 ARG A CG 1 ATOM 4032 C CD . ARG A 1 517 ? 53.661 8.283 30.445 1.00 75.66 ? 517 ARG A CD 1 ATOM 4033 N NE . ARG A 1 517 ? 55.020 8.786 30.225 1.00 77.19 ? 517 ARG A NE 1 ATOM 4034 C CZ . ARG A 1 517 ? 55.648 8.784 29.052 1.00 80.38 ? 517 ARG A CZ 1 ATOM 4035 N NH1 . ARG A 1 517 ? 55.052 8.295 27.971 1.00 60.86 ? 517 ARG A NH1 1 ATOM 4036 N NH2 . ARG A 1 517 ? 56.884 9.254 28.954 1.00 60.66 ? 517 ARG A NH2 1 ATOM 4037 N N . ALA A 1 518 ? 55.764 4.799 34.657 1.00 68.38 ? 518 ALA A N 1 ATOM 4038 C CA . ALA A 1 518 ? 56.478 3.571 35.025 1.00 68.05 ? 518 ALA A CA 1 ATOM 4039 C C . ALA A 1 518 ? 55.658 2.758 36.037 1.00 72.72 ? 518 ALA A C 1 ATOM 4040 O O . ALA A 1 518 ? 55.609 1.531 35.931 1.00 72.78 ? 518 ALA A O 1 ATOM 4041 C CB . ALA A 1 518 ? 57.846 3.908 35.595 1.00 68.50 ? 518 ALA A CB 1 ATOM 4042 N N . ALA A 1 519 ? 54.983 3.450 36.990 1.00 68.89 ? 519 ALA A N 1 ATOM 4043 C CA . ALA A 1 519 ? 54.111 2.841 37.994 1.00 68.50 ? 519 ALA A CA 1 ATOM 4044 C C . ALA A 1 519 ? 52.910 2.217 37.296 1.00 72.33 ? 519 ALA A C 1 ATOM 4045 O O . ALA A 1 519 ? 52.512 1.121 37.666 1.00 71.97 ? 519 ALA A O 1 ATOM 4046 C CB . ALA A 1 519 ? 53.648 3.883 38.998 1.00 69.24 ? 519 ALA A CB 1 ATOM 4047 N N . THR A 1 520 ? 52.363 2.899 36.261 1.00 69.04 ? 520 THR A N 1 ATOM 4048 C CA . THR A 1 520 ? 51.238 2.433 35.434 1.00 68.39 ? 520 THR A CA 1 ATOM 4049 C C . THR A 1 520 ? 51.713 1.224 34.611 1.00 69.08 ? 520 THR A C 1 ATOM 4050 O O . THR A 1 520 ? 50.977 0.247 34.506 1.00 67.67 ? 520 THR A O 1 ATOM 4051 C CB . THR A 1 520 ? 50.684 3.595 34.576 1.00 81.12 ? 520 THR A CB 1 ATOM 4052 O OG1 . THR A 1 520 ? 50.356 4.702 35.419 1.00 82.00 ? 520 THR A OG1 1 ATOM 4053 C CG2 . THR A 1 520 ? 49.457 3.203 33.764 1.00 81.02 ? 520 THR A CG2 1 ATOM 4054 N N . CYS A 1 521 ? 52.961 1.287 34.067 1.00 64.23 ? 521 CYS A N 1 ATOM 4055 C CA . CYS A 1 521 ? 53.625 0.206 33.324 1.00 63.34 ? 521 CYS A CA 1 ATOM 4056 C C . CYS A 1 521 ? 53.686 -1.039 34.223 1.00 66.11 ? 521 CYS A C 1 ATOM 4057 O O . CYS A 1 521 ? 53.162 -2.075 33.831 1.00 66.11 ? 521 CYS A O 1 ATOM 4058 C CB . CYS A 1 521 ? 55.018 0.622 32.849 1.00 63.43 ? 521 CYS A CB 1 ATOM 4059 S SG . CYS A 1 521 ? 55.066 1.338 31.184 1.00 67.27 ? 521 CYS A SG 1 ATOM 4060 N N . GLY A 1 522 ? 54.245 -0.896 35.435 1.00 60.69 ? 522 GLY A N 1 ATOM 4061 C CA . GLY A 1 522 ? 54.343 -1.965 36.423 1.00 59.92 ? 522 GLY A CA 1 ATOM 4062 C C . GLY A 1 522 ? 52.995 -2.487 36.887 1.00 64.50 ? 522 GLY A C 1 ATOM 4063 O O . GLY A 1 522 ? 52.803 -3.704 36.994 1.00 64.43 ? 522 GLY A O 1 ATOM 4064 N N . LYS A 1 523 ? 52.030 -1.567 37.121 1.00 60.93 ? 523 LYS A N 1 ATOM 4065 C CA . LYS A 1 523 ? 50.677 -1.899 37.579 1.00 60.34 ? 523 LYS A CA 1 ATOM 4066 C C . LYS A 1 523 ? 49.852 -2.632 36.527 1.00 63.38 ? 523 LYS A C 1 ATOM 4067 O O . LYS A 1 523 ? 49.148 -3.566 36.887 1.00 63.95 ? 523 LYS A O 1 ATOM 4068 C CB . LYS A 1 523 ? 49.915 -0.659 38.108 1.00 62.73 ? 523 LYS A CB 1 ATOM 4069 C CG . LYS A 1 523 ? 48.599 -0.992 38.819 1.00 80.53 ? 523 LYS A CG 1 ATOM 4070 C CD . LYS A 1 523 ? 47.527 0.093 38.684 1.00 91.58 ? 523 LYS A CD 1 ATOM 4071 C CE . LYS A 1 523 ? 46.248 -0.274 39.410 1.00 97.80 ? 523 LYS A CE 1 ATOM 4072 N NZ . LYS A 1 523 ? 45.143 0.676 39.106 1.00 103.18 ? 523 LYS A NZ 1 ATOM 4073 N N . TYR A 1 524 ? 49.911 -2.209 35.252 1.00 58.36 ? 524 TYR A N 1 ATOM 4074 C CA . TYR A 1 524 ? 49.109 -2.820 34.187 1.00 57.99 ? 524 TYR A CA 1 ATOM 4075 C C . TYR A 1 524 ? 49.801 -3.972 33.474 1.00 60.71 ? 524 TYR A C 1 ATOM 4076 O O . TYR A 1 524 ? 49.184 -5.023 33.283 1.00 60.71 ? 524 TYR A O 1 ATOM 4077 C CB . TYR A 1 524 ? 48.603 -1.765 33.172 1.00 59.42 ? 524 TYR A CB 1 ATOM 4078 C CG . TYR A 1 524 ? 47.484 -0.923 33.739 1.00 61.41 ? 524 TYR A CG 1 ATOM 4079 C CD1 . TYR A 1 524 ? 47.752 0.155 34.570 1.00 64.39 ? 524 TYR A CD1 1 ATOM 4080 C CD2 . TYR A 1 524 ? 46.154 -1.263 33.525 1.00 61.75 ? 524 TYR A CD2 1 ATOM 4081 C CE1 . TYR A 1 524 ? 46.728 0.889 35.157 1.00 67.07 ? 524 TYR A CE1 1 ATOM 4082 C CE2 . TYR A 1 524 ? 45.121 -0.539 34.111 1.00 62.46 ? 524 TYR A CE2 1 ATOM 4083 C CZ . TYR A 1 524 ? 45.412 0.544 34.920 1.00 71.98 ? 524 TYR A CZ 1 ATOM 4084 O OH . TYR A 1 524 ? 44.414 1.290 35.503 1.00 74.95 ? 524 TYR A OH 1 ATOM 4085 N N . LEU A 1 525 ? 51.069 -3.785 33.079 1.00 55.37 ? 525 LEU A N 1 ATOM 4086 C CA . LEU A 1 525 ? 51.801 -4.806 32.346 1.00 53.59 ? 525 LEU A CA 1 ATOM 4087 C C . LEU A 1 525 ? 52.217 -5.986 33.189 1.00 56.01 ? 525 LEU A C 1 ATOM 4088 O O . LEU A 1 525 ? 52.241 -7.095 32.662 1.00 54.98 ? 525 LEU A O 1 ATOM 4089 C CB . LEU A 1 525 ? 53.015 -4.215 31.602 1.00 53.07 ? 525 LEU A CB 1 ATOM 4090 C CG . LEU A 1 525 ? 52.723 -3.089 30.595 1.00 57.08 ? 525 LEU A CG 1 ATOM 4091 C CD1 . LEU A 1 525 ? 53.988 -2.456 30.098 1.00 56.75 ? 525 LEU A CD1 1 ATOM 4092 C CD2 . LEU A 1 525 ? 51.928 -3.586 29.422 1.00 59.52 ? 525 LEU A CD2 1 ATOM 4093 N N . PHE A 1 526 ? 52.499 -5.780 34.492 1.00 52.78 ? 526 PHE A N 1 ATOM 4094 C CA . PHE A 1 526 ? 53.033 -6.865 35.325 1.00 52.27 ? 526 PHE A CA 1 ATOM 4095 C C . PHE A 1 526 ? 52.153 -7.341 36.503 1.00 55.48 ? 526 PHE A C 1 ATOM 4096 O O . PHE A 1 526 ? 52.609 -8.173 37.288 1.00 52.98 ? 526 PHE A O 1 ATOM 4097 C CB . PHE A 1 526 ? 54.439 -6.487 35.802 1.00 53.67 ? 526 PHE A CB 1 ATOM 4098 C CG . PHE A 1 526 ? 55.375 -6.294 34.625 1.00 55.20 ? 526 PHE A CG 1 ATOM 4099 C CD1 . PHE A 1 526 ? 55.844 -7.384 33.901 1.00 57.97 ? 526 PHE A CD1 1 ATOM 4100 C CD2 . PHE A 1 526 ? 55.739 -5.019 34.206 1.00 57.35 ? 526 PHE A CD2 1 ATOM 4101 C CE1 . PHE A 1 526 ? 56.679 -7.203 32.794 1.00 58.67 ? 526 PHE A CE1 1 ATOM 4102 C CE2 . PHE A 1 526 ? 56.587 -4.842 33.108 1.00 59.93 ? 526 PHE A CE2 1 ATOM 4103 C CZ . PHE A 1 526 ? 57.056 -5.934 32.415 1.00 57.79 ? 526 PHE A CZ 1 ATOM 4104 N N . ASN A 1 527 ? 50.867 -6.939 36.530 1.00 54.41 ? 527 ASN A N 1 ATOM 4105 C CA . ASN A 1 527 ? 49.849 -7.335 37.524 1.00 54.93 ? 527 ASN A CA 1 ATOM 4106 C C . ASN A 1 527 ? 49.670 -8.857 37.660 1.00 58.79 ? 527 ASN A C 1 ATOM 4107 O O . ASN A 1 527 ? 49.252 -9.338 38.720 1.00 59.19 ? 527 ASN A O 1 ATOM 4108 C CB . ASN A 1 527 ? 48.499 -6.722 37.154 1.00 58.11 ? 527 ASN A CB 1 ATOM 4109 C CG . ASN A 1 527 ? 47.487 -6.792 38.259 1.00 87.90 ? 527 ASN A CG 1 ATOM 4110 O OD1 . ASN A 1 527 ? 47.640 -6.162 39.309 1.00 84.35 ? 527 ASN A OD1 1 ATOM 4111 N ND2 . ASN A 1 527 ? 46.455 -7.591 38.056 1.00 81.33 ? 527 ASN A ND2 1 ATOM 4112 N N . TRP A 1 528 ? 49.939 -9.598 36.566 1.00 53.18 ? 528 TRP A N 1 ATOM 4113 C CA . TRP A 1 528 ? 49.851 -11.052 36.494 1.00 51.43 ? 528 TRP A CA 1 ATOM 4114 C C . TRP A 1 528 ? 50.852 -11.768 37.415 1.00 60.13 ? 528 TRP A C 1 ATOM 4115 O O . TRP A 1 528 ? 50.570 -12.887 37.850 1.00 59.97 ? 528 TRP A O 1 ATOM 4116 C CB . TRP A 1 528 ? 50.041 -11.513 35.045 1.00 48.13 ? 528 TRP A CB 1 ATOM 4117 C CG . TRP A 1 528 ? 51.326 -11.070 34.409 1.00 47.55 ? 528 TRP A CG 1 ATOM 4118 C CD1 . TRP A 1 528 ? 51.514 -9.968 33.632 1.00 50.07 ? 528 TRP A CD1 1 ATOM 4119 C CD2 . TRP A 1 528 ? 52.589 -11.756 34.447 1.00 46.73 ? 528 TRP A CD2 1 ATOM 4120 N NE1 . TRP A 1 528 ? 52.817 -9.916 33.187 1.00 48.78 ? 528 TRP A NE1 1 ATOM 4121 C CE2 . TRP A 1 528 ? 53.498 -11.000 33.672 1.00 49.82 ? 528 TRP A CE2 1 ATOM 4122 C CE3 . TRP A 1 528 ? 53.040 -12.946 35.056 1.00 47.27 ? 528 TRP A CE3 1 ATOM 4123 C CZ2 . TRP A 1 528 ? 54.830 -11.378 33.505 1.00 48.62 ? 528 TRP A CZ2 1 ATOM 4124 C CZ3 . TRP A 1 528 ? 54.365 -13.306 34.910 1.00 48.36 ? 528 TRP A CZ3 1 ATOM 4125 C CH2 . TRP A 1 528 ? 55.241 -12.541 34.124 1.00 48.95 ? 528 TRP A CH2 1 ATOM 4126 N N . ALA A 1 529 ? 52.023 -11.129 37.694 1.00 60.07 ? 529 ALA A N 1 ATOM 4127 C CA . ALA A 1 529 ? 53.130 -11.674 38.494 1.00 60.75 ? 529 ALA A CA 1 ATOM 4128 C C . ALA A 1 529 ? 52.931 -11.631 39.999 1.00 67.89 ? 529 ALA A C 1 ATOM 4129 O O . ALA A 1 529 ? 53.441 -12.510 40.693 1.00 68.03 ? 529 ALA A O 1 ATOM 4130 C CB . ALA A 1 529 ? 54.433 -10.984 38.128 1.00 61.21 ? 529 ALA A CB 1 ATOM 4131 N N . VAL A 1 530 ? 52.221 -10.620 40.511 1.00 67.19 ? 530 VAL A N 1 ATOM 4132 C CA . VAL A 1 530 ? 52.019 -10.461 41.954 1.00 68.72 ? 530 VAL A CA 1 ATOM 4133 C C . VAL A 1 530 ? 50.932 -11.365 42.526 1.00 77.65 ? 530 VAL A C 1 ATOM 4134 O O . VAL A 1 530 ? 49.938 -11.655 41.852 1.00 77.82 ? 530 VAL A O 1 ATOM 4135 C CB . VAL A 1 530 ? 51.811 -8.997 42.413 1.00 72.22 ? 530 VAL A CB 1 ATOM 4136 C CG1 . VAL A 1 530 ? 53.132 -8.251 42.436 1.00 72.24 ? 530 VAL A CG1 1 ATOM 4137 C CG2 . VAL A 1 530 ? 50.765 -8.260 41.579 1.00 71.75 ? 530 VAL A CG2 1 ATOM 4138 N N . LYS A 1 531 ? 51.129 -11.791 43.793 1.00 76.90 ? 531 LYS A N 1 ATOM 4139 C CA . LYS A 1 531 ? 50.171 -12.620 44.527 1.00 77.80 ? 531 LYS A CA 1 ATOM 4140 C C . LYS A 1 531 ? 48.964 -11.786 45.005 1.00 84.85 ? 531 LYS A C 1 ATOM 4141 O O . LYS A 1 531 ? 47.869 -12.325 45.162 1.00 84.49 ? 531 LYS A O 1 ATOM 4142 C CB . LYS A 1 531 ? 50.842 -13.430 45.662 1.00 79.92 ? 531 LYS A CB 1 ATOM 4143 C CG . LYS A 1 531 ? 51.916 -12.695 46.469 1.00 92.35 ? 531 LYS A CG 1 ATOM 4144 C CD . LYS A 1 531 ? 52.469 -13.574 47.587 1.00 100.74 ? 531 LYS A CD 1 ATOM 4145 C CE . LYS A 1 531 ? 53.349 -12.820 48.555 1.00 105.98 ? 531 LYS A CE 1 ATOM 4146 N NZ . LYS A 1 531 ? 53.754 -13.671 49.708 1.00 110.66 ? 531 LYS A NZ 1 ATOM 4147 N N . THR A 1 532 ? 49.157 -10.468 45.184 1.00 84.18 ? 532 THR A N 1 ATOM 4148 C CA . THR A 1 532 ? 48.104 -9.533 45.587 1.00 85.55 ? 532 THR A CA 1 ATOM 4149 C C . THR A 1 532 ? 47.720 -8.671 44.363 1.00 92.36 ? 532 THR A C 1 ATOM 4150 O O . THR A 1 532 ? 48.320 -7.614 44.131 1.00 92.72 ? 532 THR A O 1 ATOM 4151 C CB . THR A 1 532 ? 48.528 -8.732 46.850 1.00 93.03 ? 532 THR A CB 1 ATOM 4152 O OG1 . THR A 1 532 ? 48.921 -9.639 47.889 1.00 90.76 ? 532 THR A OG1 1 ATOM 4153 C CG2 . THR A 1 532 ? 47.424 -7.795 47.355 1.00 90.70 ? 532 THR A CG2 1 ATOM 4154 N N . LYS A 1 533 ? 46.740 -9.147 43.570 1.00 89.94 ? 533 LYS A N 1 ATOM 4155 C CA . LYS A 1 533 ? 46.281 -8.465 42.358 1.00 90.42 ? 533 LYS A CA 1 ATOM 4156 C C . LYS A 1 533 ? 45.648 -7.091 42.626 1.00 96.87 ? 533 LYS A C 1 ATOM 4157 O O . LYS A 1 533 ? 45.144 -6.825 43.723 1.00 96.24 ? 533 LYS A O 1 ATOM 4158 C CB . LYS A 1 533 ? 45.347 -9.364 41.528 1.00 92.29 ? 533 LYS A CB 1 ATOM 4159 C CG . LYS A 1 533 ? 46.044 -10.100 40.387 1.00 95.79 ? 533 LYS A CG 1 ATOM 4160 C CD . LYS A 1 533 ? 46.723 -11.386 40.830 1.00 101.13 ? 533 LYS A CD 1 ATOM 4161 C CE . LYS A 1 533 ? 47.409 -12.059 39.669 1.00 109.91 ? 533 LYS A CE 1 ATOM 4162 N NZ . LYS A 1 533 ? 48.310 -13.153 40.119 1.00 117.01 ? 533 LYS A NZ 1 ATOM 4163 N N . LEU A 1 534 ? 45.723 -6.214 41.611 1.00 95.48 ? 534 LEU A N 1 ATOM 4164 C CA . LEU A 1 534 ? 45.217 -4.838 41.630 1.00 95.91 ? 534 LEU A CA 1 ATOM 4165 C C . LEU A 1 534 ? 44.111 -4.649 40.583 1.00 101.20 ? 534 LEU A C 1 ATOM 4166 O O . LEU A 1 534 ? 44.191 -5.238 39.494 1.00 100.83 ? 534 LEU A O 1 ATOM 4167 C CB . LEU A 1 534 ? 46.371 -3.840 41.357 1.00 95.74 ? 534 LEU A CB 1 ATOM 4168 C CG . LEU A 1 534 ? 47.262 -3.441 42.539 1.00 99.76 ? 534 LEU A CG 1 ATOM 4169 C CD1 . LEU A 1 534 ? 48.286 -4.517 42.864 1.00 99.52 ? 534 LEU A CD1 1 ATOM 4170 C CD2 . LEU A 1 534 ? 48.003 -2.167 42.236 1.00 101.46 ? 534 LEU A CD2 1 ATOM 4171 N N . LYS A 1 535 ? 43.091 -3.812 40.905 1.00 98.27 ? 535 LYS A N 1 ATOM 4172 C CA . LYS A 1 535 ? 41.984 -3.523 39.981 1.00 98.08 ? 535 LYS A CA 1 ATOM 4173 C C . LYS A 1 535 ? 42.441 -2.590 38.859 1.00 102.45 ? 535 LYS A C 1 ATOM 4174 O O . LYS A 1 535 ? 42.609 -1.387 39.063 1.00 101.78 ? 535 LYS A O 1 ATOM 4175 C CB . LYS A 1 535 ? 40.706 -3.016 40.707 1.00 100.13 ? 535 LYS A CB 1 ATOM 4176 C CG . LYS A 1 535 ? 39.532 -2.618 39.795 1.00 106.47 ? 535 LYS A CG 1 ATOM 4177 C CD . LYS A 1 535 ? 38.351 -3.609 39.787 1.00 109.25 ? 535 LYS A CD 1 ATOM 4178 C CE . LYS A 1 535 ? 37.243 -3.160 38.864 1.00 109.48 ? 535 LYS A CE 1 ATOM 4179 N NZ . LYS A 1 535 ? 36.267 -4.249 38.621 1.00 110.04 ? 535 LYS A NZ 1 ATOM 4180 N N . LEU A 1 536 ? 42.625 -3.182 37.675 1.00 99.65 ? 536 LEU A N 1 ATOM 4181 C CA . LEU A 1 536 ? 43.061 -2.514 36.454 1.00 99.73 ? 536 LEU A CA 1 ATOM 4182 C C . LEU A 1 536 ? 41.889 -1.725 35.853 1.00 104.74 ? 536 LEU A C 1 ATOM 4183 O O . LEU A 1 536 ? 40.817 -2.286 35.608 1.00 104.21 ? 536 LEU A O 1 ATOM 4184 C CB . LEU A 1 536 ? 43.644 -3.550 35.466 1.00 99.52 ? 536 LEU A CB 1 ATOM 4185 C CG . LEU A 1 536 ? 44.695 -4.511 36.052 1.00 103.52 ? 536 LEU A CG 1 ATOM 4186 C CD1 . LEU A 1 536 ? 44.838 -5.742 35.216 1.00 103.45 ? 536 LEU A CD1 1 ATOM 4187 C CD2 . LEU A 1 536 ? 46.028 -3.838 36.226 1.00 105.48 ? 536 LEU A CD2 1 ATOM 4188 N N . THR A 1 537 ? 42.092 -0.405 35.683 1.00 102.07 ? 537 THR A N 1 ATOM 4189 C CA . THR A 1 537 ? 41.108 0.578 35.198 1.00 102.16 ? 537 THR A CA 1 ATOM 4190 C C . THR A 1 537 ? 41.563 1.254 33.877 1.00 106.53 ? 537 THR A C 1 ATOM 4191 O O . THR A 1 537 ? 42.701 1.041 33.480 1.00 106.60 ? 537 THR A O 1 ATOM 4192 C CB . THR A 1 537 ? 40.865 1.611 36.314 1.00 110.88 ? 537 THR A CB 1 ATOM 4193 O OG1 . THR A 1 537 ? 42.126 2.057 36.820 1.00 110.35 ? 537 THR A OG1 1 ATOM 4194 C CG2 . THR A 1 537 ? 40.007 1.056 37.452 1.00 110.13 ? 537 THR A CG2 1 ATOM 4195 N N . PRO A 1 538 ? 40.743 2.071 33.168 1.00 103.06 ? 538 PRO A N 1 ATOM 4196 C CA . PRO A 1 538 ? 41.234 2.688 31.914 1.00 102.93 ? 538 PRO A CA 1 ATOM 4197 C C . PRO A 1 538 ? 42.292 3.779 32.113 1.00 106.32 ? 538 PRO A C 1 ATOM 4198 O O . PRO A 1 538 ? 42.323 4.422 33.164 1.00 106.08 ? 538 PRO A O 1 ATOM 4199 C CB . PRO A 1 538 ? 39.969 3.264 31.272 1.00 104.70 ? 538 PRO A CB 1 ATOM 4200 C CG . PRO A 1 538 ? 38.838 2.726 32.068 1.00 109.15 ? 538 PRO A CG 1 ATOM 4201 C CD . PRO A 1 538 ? 39.345 2.454 33.427 1.00 104.63 ? 538 PRO A CD 1 ATOM 4202 N N . ILE A 1 539 ? 43.147 4.001 31.090 1.00 102.03 ? 539 ILE A N 1 ATOM 4203 C CA . ILE A 1 539 ? 44.220 5.004 31.132 1.00 121.39 ? 539 ILE A CA 1 ATOM 4204 C C . ILE A 1 539 ? 43.974 6.106 30.080 1.00 112.54 ? 539 ILE A C 1 ATOM 4205 O O . ILE A 1 539 ? 44.273 7.284 30.303 1.00 54.88 ? 539 ILE A O 1 ATOM 4206 C CB . ILE A 1 539 ? 45.640 4.361 30.995 1.00 124.60 ? 539 ILE A CB 1 ATOM 4207 C CG1 . ILE A 1 539 ? 45.735 2.957 31.645 1.00 124.77 ? 539 ILE A CG1 1 ATOM 4208 C CG2 . ILE A 1 539 ? 46.725 5.288 31.552 1.00 125.70 ? 539 ILE A CG2 1 ATOM 4209 C CD1 . ILE A 1 539 ? 45.885 1.828 30.673 1.00 129.51 ? 539 ILE A CD1 1 ATOM 4210 N N . PHE A 1 551 ? 43.788 1.988 12.954 1.00 70.22 ? 551 PHE A N 1 ATOM 4211 C CA . PHE A 1 551 ? 44.132 1.023 11.913 1.00 70.00 ? 551 PHE A CA 1 ATOM 4212 C C . PHE A 1 551 ? 43.378 1.306 10.610 1.00 73.68 ? 551 PHE A C 1 ATOM 4213 O O . PHE A 1 551 ? 42.139 1.325 10.588 1.00 72.75 ? 551 PHE A O 1 ATOM 4214 C CB . PHE A 1 551 ? 43.893 -0.421 12.385 1.00 71.86 ? 551 PHE A CB 1 ATOM 4215 C CG . PHE A 1 551 ? 45.004 -1.035 13.205 1.00 73.86 ? 551 PHE A CG 1 ATOM 4216 C CD1 . PHE A 1 551 ? 46.064 -1.691 12.590 1.00 77.51 ? 551 PHE A CD1 1 ATOM 4217 C CD2 . PHE A 1 551 ? 44.972 -0.991 14.593 1.00 76.20 ? 551 PHE A CD2 1 ATOM 4218 C CE1 . PHE A 1 551 ? 47.087 -2.279 13.352 1.00 78.34 ? 551 PHE A CE1 1 ATOM 4219 C CE2 . PHE A 1 551 ? 45.986 -1.591 15.353 1.00 79.08 ? 551 PHE A CE2 1 ATOM 4220 C CZ . PHE A 1 551 ? 47.037 -2.230 14.726 1.00 77.13 ? 551 PHE A CZ 1 ATOM 4221 N N . VAL A 1 552 ? 44.141 1.548 9.525 1.00 70.24 ? 552 VAL A N 1 ATOM 4222 C CA . VAL A 1 552 ? 43.603 1.846 8.194 1.00 69.87 ? 552 VAL A CA 1 ATOM 4223 C C . VAL A 1 552 ? 44.140 0.865 7.141 1.00 71.72 ? 552 VAL A C 1 ATOM 4224 O O . VAL A 1 552 ? 43.331 0.259 6.430 1.00 71.41 ? 552 VAL A O 1 ATOM 4225 C CB . VAL A 1 552 ? 43.802 3.343 7.802 1.00 74.22 ? 552 VAL A CB 1 ATOM 4226 C CG1 . VAL A 1 552 ? 43.590 3.585 6.305 1.00 74.11 ? 552 VAL A CG1 1 ATOM 4227 C CG2 . VAL A 1 552 ? 42.887 4.248 8.623 1.00 74.13 ? 552 VAL A CG2 1 ATOM 4228 N N . ALA A 1 553 ? 45.487 0.713 7.040 1.00 66.53 ? 553 ALA A N 1 ATOM 4229 C CA . ALA A 1 553 ? 46.135 -0.161 6.049 1.00 65.68 ? 553 ALA A CA 1 ATOM 4230 C C . ALA A 1 553 ? 47.570 -0.612 6.415 1.00 68.59 ? 553 ALA A C 1 ATOM 4231 O O . ALA A 1 553 ? 48.197 -0.057 7.324 1.00 68.27 ? 553 ALA A O 1 ATOM 4232 C CB . ALA A 1 553 ? 46.134 0.521 4.677 1.00 66.40 ? 553 ALA A CB 1 ATOM 4233 N N . GLY A 1 554 ? 48.057 -1.613 5.681 1.00 64.31 ? 554 GLY A N 1 ATOM 4234 C CA . GLY A 1 554 ? 49.397 -2.171 5.803 1.00 64.28 ? 554 GLY A CA 1 ATOM 4235 C C . GLY A 1 554 ? 50.291 -1.588 4.728 1.00 69.66 ? 554 GLY A C 1 ATOM 4236 O O . GLY A 1 554 ? 49.852 -1.426 3.583 1.00 69.30 ? 554 GLY A O 1 ATOM 4237 N N . TYR A 1 555 ? 51.535 -1.221 5.092 1.00 66.70 ? 555 TYR A N 1 ATOM 4238 C CA . TYR A 1 555 ? 52.475 -0.580 4.165 1.00 66.48 ? 555 TYR A CA 1 ATOM 4239 C C . TYR A 1 555 ? 53.829 -1.313 4.066 1.00 72.97 ? 555 TYR A C 1 ATOM 4240 O O . TYR A 1 555 ? 54.892 -0.677 4.060 1.00 72.80 ? 555 TYR A O 1 ATOM 4241 C CB . TYR A 1 555 ? 52.648 0.916 4.522 1.00 66.55 ? 555 TYR A CB 1 ATOM 4242 C CG . TYR A 1 555 ? 51.348 1.690 4.551 1.00 66.54 ? 555 TYR A CG 1 ATOM 4243 C CD1 . TYR A 1 555 ? 50.787 2.198 3.381 1.00 68.21 ? 555 TYR A CD1 1 ATOM 4244 C CD2 . TYR A 1 555 ? 50.667 1.901 5.747 1.00 66.46 ? 555 TYR A CD2 1 ATOM 4245 C CE1 . TYR A 1 555 ? 49.578 2.896 3.401 1.00 68.37 ? 555 TYR A CE1 1 ATOM 4246 C CE2 . TYR A 1 555 ? 49.456 2.592 5.778 1.00 66.82 ? 555 TYR A CE2 1 ATOM 4247 C CZ . TYR A 1 555 ? 48.915 3.090 4.602 1.00 70.51 ? 555 TYR A CZ 1 ATOM 4248 O OH . TYR A 1 555 ? 47.728 3.782 4.630 1.00 65.73 ? 555 TYR A OH 1 ATOM 4249 N N . SER A 1 556 ? 53.777 -2.661 3.968 1.00 70.92 ? 556 SER A N 1 ATOM 4250 C CA . SER A 1 556 ? 54.946 -3.542 3.855 1.00 70.77 ? 556 SER A CA 1 ATOM 4251 C C . SER A 1 556 ? 55.702 -3.293 2.543 1.00 74.00 ? 556 SER A C 1 ATOM 4252 O O . SER A 1 556 ? 55.191 -3.581 1.452 1.00 72.79 ? 556 SER A O 1 ATOM 4253 C CB . SER A 1 556 ? 54.540 -5.006 4.020 1.00 74.29 ? 556 SER A CB 1 ATOM 4254 O OG . SER A 1 556 ? 55.637 -5.891 3.862 1.00 81.73 ? 556 SER A OG 1 ATOM 4255 N N . GLY A 1 557 ? 56.890 -2.698 2.687 1.00 71.06 ? 557 GLY A N 1 ATOM 4256 C CA . GLY A 1 557 ? 57.776 -2.303 1.593 1.00 70.66 ? 557 GLY A CA 1 ATOM 4257 C C . GLY A 1 557 ? 57.516 -0.889 1.108 1.00 74.07 ? 557 GLY A C 1 ATOM 4258 O O . GLY A 1 557 ? 58.365 -0.289 0.448 1.00 73.21 ? 557 GLY A O 1 ATOM 4259 N N . GLY A 1 558 ? 56.345 -0.365 1.476 1.00 71.08 ? 558 GLY A N 1 ATOM 4260 C CA . GLY A 1 558 ? 55.834 0.949 1.111 1.00 70.85 ? 558 GLY A CA 1 ATOM 4261 C C . GLY A 1 558 ? 56.602 2.181 1.539 1.00 74.84 ? 558 GLY A C 1 ATOM 4262 O O . GLY A 1 558 ? 56.348 3.252 0.990 1.00 74.93 ? 558 GLY A O 1 ATOM 4263 N N . ASP A 1 559 ? 57.528 2.068 2.517 1.00 71.17 ? 559 ASP A N 1 ATOM 4264 C CA . ASP A 1 559 ? 58.326 3.198 3.015 1.00 70.86 ? 559 ASP A CA 1 ATOM 4265 C C . ASP A 1 559 ? 57.376 4.253 3.619 1.00 76.11 ? 559 ASP A C 1 ATOM 4266 O O . ASP A 1 559 ? 57.246 5.332 3.059 1.00 75.49 ? 559 ASP A O 1 ATOM 4267 C CB . ASP A 1 559 ? 59.211 3.776 1.868 1.00 72.18 ? 559 ASP A CB 1 ATOM 4268 C CG . ASP A 1 559 ? 60.311 4.737 2.263 1.00 78.48 ? 559 ASP A CG 1 ATOM 4269 O OD1 . ASP A 1 559 ? 61.187 4.338 3.053 1.00 81.33 ? 559 ASP A OD1 1 ATOM 4270 O OD2 . ASP A 1 559 ? 60.352 5.854 1.701 1.00 75.57 ? 559 ASP A OD2 1 ATOM 4271 N N . ILE A 1 560 ? 56.664 3.913 4.724 1.00 74.34 ? 560 ILE A N 1 ATOM 4272 C CA . ILE A 1 560 ? 55.694 4.802 5.396 1.00 74.40 ? 560 ILE A CA 1 ATOM 4273 C C . ILE A 1 560 ? 55.978 4.943 6.900 1.00 80.77 ? 560 ILE A C 1 ATOM 4274 O O . ILE A 1 560 ? 56.239 3.950 7.580 1.00 79.87 ? 560 ILE A O 1 ATOM 4275 C CB . ILE A 1 560 ? 54.218 4.378 5.100 1.00 76.99 ? 560 ILE A CB 1 ATOM 4276 C CG1 . ILE A 1 560 ? 53.856 4.501 3.591 1.00 77.43 ? 560 ILE A CG1 1 ATOM 4277 C CG2 . ILE A 1 560 ? 53.183 5.098 5.977 1.00 77.03 ? 560 ILE A CG2 1 ATOM 4278 C CD1 . ILE A 1 560 ? 54.101 5.877 2.915 1.00 84.19 ? 560 ILE A CD1 1 ATOM 4279 N N . TYR A 1 561 ? 55.913 6.191 7.408 1.00 80.05 ? 561 TYR A N 1 ATOM 4280 C CA . TYR A 1 561 ? 56.117 6.512 8.820 1.00 80.81 ? 561 TYR A CA 1 ATOM 4281 C C . TYR A 1 561 ? 54.970 7.348 9.404 1.00 84.99 ? 561 TYR A C 1 ATOM 4282 O O . TYR A 1 561 ? 54.634 8.405 8.862 1.00 84.24 ? 561 TYR A O 1 ATOM 4283 C CB . TYR A 1 561 ? 57.476 7.192 9.042 1.00 82.89 ? 561 TYR A CB 1 ATOM 4284 C CG . TYR A 1 561 ? 57.678 7.729 10.444 1.00 86.24 ? 561 TYR A CG 1 ATOM 4285 C CD1 . TYR A 1 561 ? 58.217 6.930 11.448 1.00 88.40 ? 561 TYR A CD1 1 ATOM 4286 C CD2 . TYR A 1 561 ? 57.324 9.035 10.768 1.00 87.64 ? 561 TYR A CD2 1 ATOM 4287 C CE1 . TYR A 1 561 ? 58.392 7.418 12.744 1.00 89.96 ? 561 TYR A CE1 1 ATOM 4288 C CE2 . TYR A 1 561 ? 57.486 9.530 12.060 1.00 88.92 ? 561 TYR A CE2 1 ATOM 4289 C CZ . TYR A 1 561 ? 58.029 8.721 13.042 1.00 97.63 ? 561 TYR A CZ 1 ATOM 4290 O OH . TYR A 1 561 ? 58.208 9.232 14.303 1.00 100.22 ? 561 TYR A OH 1 ATOM 4291 N N . HIS A 1 562 ? 54.419 6.889 10.547 1.00 81.94 ? 562 HIS A N 1 ATOM 4292 C CA . HIS A 1 562 ? 53.347 7.557 11.288 1.00 108.45 ? 562 HIS A CA 1 ATOM 4293 C C . HIS A 1 562 ? 53.858 8.083 12.636 1.00 125.71 ? 562 HIS A C 1 ATOM 4294 O O . HIS A 1 562 ? 54.676 7.440 13.297 1.00 80.44 ? 562 HIS A O 1 ATOM 4295 C CB . HIS A 1 562 ? 52.163 6.608 11.508 1.00 109.18 ? 562 HIS A CB 1 ATOM 4296 C CG . HIS A 1 562 ? 51.527 6.118 10.247 1.00 112.58 ? 562 HIS A CG 1 ATOM 4297 N ND1 . HIS A 1 562 ? 50.678 6.921 9.508 1.00 114.43 ? 562 HIS A ND1 1 ATOM 4298 C CD2 . HIS A 1 562 ? 51.616 4.908 9.648 1.00 114.28 ? 562 HIS A CD2 1 ATOM 4299 C CE1 . HIS A 1 562 ? 50.288 6.182 8.483 1.00 113.77 ? 562 HIS A CE1 1 ATOM 4300 N NE2 . HIS A 1 562 ? 50.824 4.963 8.525 1.00 114.04 ? 562 HIS A NE2 1 ATOM 4301 N N . HIS B 1 1 ? 15.959 15.299 43.495 1.00 44.34 ? 1 HIS B N 1 ATOM 4302 C CA . HIS B 1 1 ? 15.238 14.776 42.319 1.00 43.90 ? 1 HIS B CA 1 ATOM 4303 C C . HIS B 1 1 ? 15.960 15.033 40.989 1.00 44.48 ? 1 HIS B C 1 ATOM 4304 O O . HIS B 1 1 ? 15.300 15.249 39.974 1.00 43.67 ? 1 HIS B O 1 ATOM 4305 C CB . HIS B 1 1 ? 13.796 15.327 42.248 1.00 44.80 ? 1 HIS B CB 1 ATOM 4306 C CG . HIS B 1 1 ? 12.948 14.974 43.422 1.00 47.96 ? 1 HIS B CG 1 ATOM 4307 N ND1 . HIS B 1 1 ? 12.502 15.945 44.302 1.00 49.72 ? 1 HIS B ND1 1 ATOM 4308 C CD2 . HIS B 1 1 ? 12.505 13.765 43.834 1.00 49.63 ? 1 HIS B CD2 1 ATOM 4309 C CE1 . HIS B 1 1 ? 11.805 15.298 45.221 1.00 49.44 ? 1 HIS B CE1 1 ATOM 4310 N NE2 . HIS B 1 1 ? 11.783 13.982 44.982 1.00 49.75 ? 1 HIS B NE2 1 ATOM 4311 N N . MET B 1 2 ? 17.303 14.973 40.987 1.00 39.89 ? 2 MET B N 1 ATOM 4312 C CA . MET B 1 2 ? 18.128 15.215 39.794 1.00 39.44 ? 2 MET B CA 1 ATOM 4313 C C . MET B 1 2 ? 17.961 14.139 38.735 1.00 39.58 ? 2 MET B C 1 ATOM 4314 O O . MET B 1 2 ? 18.146 12.949 39.032 1.00 38.68 ? 2 MET B O 1 ATOM 4315 C CB . MET B 1 2 ? 19.631 15.342 40.156 1.00 42.11 ? 2 MET B CB 1 ATOM 4316 C CG . MET B 1 2 ? 19.962 16.508 41.089 1.00 46.11 ? 2 MET B CG 1 ATOM 4317 S SD . MET B 1 2 ? 19.325 18.098 40.513 1.00 50.59 ? 2 MET B SD 1 ATOM 4318 C CE . MET B 1 2 ? 20.385 18.369 39.090 1.00 47.58 ? 2 MET B CE 1 ATOM 4319 N N . SER B 1 3 ? 17.676 14.556 37.483 1.00 33.01 ? 3 SER B N 1 ATOM 4320 C CA . SER B 1 3 ? 17.576 13.615 36.366 1.00 31.47 ? 3 SER B CA 1 ATOM 4321 C C . SER B 1 3 ? 18.822 12.703 36.297 1.00 34.98 ? 3 SER B C 1 ATOM 4322 O O . SER B 1 3 ? 18.689 11.504 36.041 1.00 35.43 ? 3 SER B O 1 ATOM 4323 C CB . SER B 1 3 ? 17.368 14.352 35.049 1.00 31.56 ? 3 SER B CB 1 ATOM 4324 O OG . SER B 1 3 ? 18.350 15.359 34.910 1.00 31.60 ? 3 SER B OG 1 ATOM 4325 N N . TYR B 1 4 ? 20.015 13.261 36.577 1.00 30.58 ? 4 TYR B N 1 ATOM 4326 C CA . TYR B 1 4 ? 21.281 12.529 36.574 1.00 30.62 ? 4 TYR B CA 1 ATOM 4327 C C . TYR B 1 4 ? 22.237 13.069 37.611 1.00 37.94 ? 4 TYR B C 1 ATOM 4328 O O . TYR B 1 4 ? 22.296 14.280 37.795 1.00 38.92 ? 4 TYR B O 1 ATOM 4329 C CB . TYR B 1 4 ? 21.989 12.655 35.214 1.00 30.65 ? 4 TYR B CB 1 ATOM 4330 C CG . TYR B 1 4 ? 21.217 12.131 34.025 1.00 31.45 ? 4 TYR B CG 1 ATOM 4331 C CD1 . TYR B 1 4 ? 21.364 10.818 33.600 1.00 33.30 ? 4 TYR B CD1 1 ATOM 4332 C CD2 . TYR B 1 4 ? 20.390 12.973 33.277 1.00 31.93 ? 4 TYR B CD2 1 ATOM 4333 C CE1 . TYR B 1 4 ? 20.668 10.336 32.492 1.00 35.01 ? 4 TYR B CE1 1 ATOM 4334 C CE2 . TYR B 1 4 ? 19.690 12.504 32.169 1.00 32.40 ? 4 TYR B CE2 1 ATOM 4335 C CZ . TYR B 1 4 ? 19.842 11.187 31.771 1.00 42.04 ? 4 TYR B CZ 1 ATOM 4336 O OH . TYR B 1 4 ? 19.118 10.710 30.703 1.00 45.10 ? 4 TYR B OH 1 ATOM 4337 N N . THR B 1 5 ? 23.008 12.185 38.266 1.00 35.90 ? 5 THR B N 1 ATOM 4338 C CA . THR B 1 5 ? 24.112 12.572 39.148 1.00 37.16 ? 5 THR B CA 1 ATOM 4339 C C . THR B 1 5 ? 25.356 11.995 38.497 1.00 44.99 ? 5 THR B C 1 ATOM 4340 O O . THR B 1 5 ? 25.281 10.894 37.936 1.00 45.05 ? 5 THR B O 1 ATOM 4341 C CB . THR B 1 5 ? 23.944 12.217 40.636 1.00 44.85 ? 5 THR B CB 1 ATOM 4342 O OG1 . THR B 1 5 ? 23.323 10.946 40.799 1.00 48.22 ? 5 THR B OG1 1 ATOM 4343 C CG2 . THR B 1 5 ? 23.218 13.296 41.413 1.00 43.04 ? 5 THR B CG2 1 ATOM 4344 N N . TRP B 1 6 ? 26.469 12.767 38.480 1.00 42.63 ? 6 TRP B N 1 ATOM 4345 C CA . TRP B 1 6 ? 27.700 12.347 37.807 1.00 42.58 ? 6 TRP B CA 1 ATOM 4346 C C . TRP B 1 6 ? 28.907 12.216 38.735 1.00 47.25 ? 6 TRP B C 1 ATOM 4347 O O . TRP B 1 6 ? 28.934 12.802 39.818 1.00 47.56 ? 6 TRP B O 1 ATOM 4348 C CB . TRP B 1 6 ? 28.010 13.272 36.629 1.00 40.95 ? 6 TRP B CB 1 ATOM 4349 C CG . TRP B 1 6 ? 26.856 13.454 35.690 1.00 41.90 ? 6 TRP B CG 1 ATOM 4350 C CD1 . TRP B 1 6 ? 26.001 14.511 35.648 1.00 44.87 ? 6 TRP B CD1 1 ATOM 4351 C CD2 . TRP B 1 6 ? 26.431 12.551 34.653 1.00 41.87 ? 6 TRP B CD2 1 ATOM 4352 N NE1 . TRP B 1 6 ? 25.081 14.339 34.634 1.00 44.63 ? 6 TRP B NE1 1 ATOM 4353 C CE2 . TRP B 1 6 ? 25.336 13.155 33.994 1.00 45.69 ? 6 TRP B CE2 1 ATOM 4354 C CE3 . TRP B 1 6 ? 26.881 11.294 34.204 1.00 43.15 ? 6 TRP B CE3 1 ATOM 4355 C CZ2 . TRP B 1 6 ? 24.680 12.548 32.918 1.00 44.80 ? 6 TRP B CZ2 1 ATOM 4356 C CZ3 . TRP B 1 6 ? 26.228 10.693 33.138 1.00 44.51 ? 6 TRP B CZ3 1 ATOM 4357 C CH2 . TRP B 1 6 ? 25.141 11.317 32.509 1.00 45.10 ? 6 TRP B CH2 1 ATOM 4358 N N . THR B 1 7 ? 29.892 11.420 38.309 1.00 42.42 ? 7 THR B N 1 ATOM 4359 C CA . THR B 1 7 ? 31.104 11.162 39.072 1.00 41.50 ? 7 THR B CA 1 ATOM 4360 C C . THR B 1 7 ? 32.262 12.011 38.536 1.00 45.60 ? 7 THR B C 1 ATOM 4361 O O . THR B 1 7 ? 33.043 12.555 39.315 1.00 47.31 ? 7 THR B O 1 ATOM 4362 C CB . THR B 1 7 ? 31.445 9.663 39.030 1.00 45.08 ? 7 THR B CB 1 ATOM 4363 O OG1 . THR B 1 7 ? 31.735 9.308 37.679 1.00 42.56 ? 7 THR B OG1 1 ATOM 4364 C CG2 . THR B 1 7 ? 30.325 8.773 39.574 1.00 40.50 ? 7 THR B CG2 1 ATOM 4365 N N . GLY B 1 8 ? 32.361 12.108 37.220 1.00 39.80 ? 8 GLY B N 1 ATOM 4366 C CA . GLY B 1 8 ? 33.430 12.832 36.550 1.00 38.67 ? 8 GLY B CA 1 ATOM 4367 C C . GLY B 1 8 ? 34.081 11.990 35.474 1.00 42.63 ? 8 GLY B C 1 ATOM 4368 O O . GLY B 1 8 ? 34.867 12.507 34.682 1.00 43.75 ? 8 GLY B O 1 ATOM 4369 N N . ALA B 1 9 ? 33.770 10.679 35.444 1.00 38.22 ? 9 ALA B N 1 ATOM 4370 C CA . ALA B 1 9 ? 34.252 9.753 34.431 1.00 38.17 ? 9 ALA B CA 1 ATOM 4371 C C . ALA B 1 9 ? 33.551 10.093 33.109 1.00 46.11 ? 9 ALA B C 1 ATOM 4372 O O . ALA B 1 9 ? 32.334 10.333 33.074 1.00 45.54 ? 9 ALA B O 1 ATOM 4373 C CB . ALA B 1 9 ? 33.960 8.321 34.833 1.00 38.47 ? 9 ALA B CB 1 ATOM 4374 N N . LEU B 1 10 ? 34.345 10.185 32.040 1.00 44.83 ? 10 LEU B N 1 ATOM 4375 C CA . LEU B 1 10 ? 33.857 10.540 30.716 1.00 45.21 ? 10 LEU B CA 1 ATOM 4376 C C . LEU B 1 10 ? 33.114 9.397 30.053 1.00 51.73 ? 10 LEU B C 1 ATOM 4377 O O . LEU B 1 10 ? 33.378 8.228 30.343 1.00 52.67 ? 10 LEU B O 1 ATOM 4378 C CB . LEU B 1 10 ? 35.024 11.000 29.806 1.00 44.63 ? 10 LEU B CB 1 ATOM 4379 C CG . LEU B 1 10 ? 35.813 12.225 30.263 1.00 47.78 ? 10 LEU B CG 1 ATOM 4380 C CD1 . LEU B 1 10 ? 36.980 12.476 29.356 1.00 47.02 ? 10 LEU B CD1 1 ATOM 4381 C CD2 . LEU B 1 10 ? 34.923 13.462 30.382 1.00 49.20 ? 10 LEU B CD2 1 ATOM 4382 N N . ILE B 1 11 ? 32.177 9.750 29.156 1.00 47.95 ? 11 ILE B N 1 ATOM 4383 C CA . ILE B 1 11 ? 31.443 8.812 28.323 1.00 47.08 ? 11 ILE B CA 1 ATOM 4384 C C . ILE B 1 11 ? 32.447 8.529 27.184 1.00 51.69 ? 11 ILE B C 1 ATOM 4385 O O . ILE B 1 11 ? 32.833 9.444 26.454 1.00 50.44 ? 11 ILE B O 1 ATOM 4386 C CB . ILE B 1 11 ? 30.094 9.426 27.851 1.00 49.51 ? 11 ILE B CB 1 ATOM 4387 C CG1 . ILE B 1 11 ? 29.194 9.753 29.055 1.00 49.38 ? 11 ILE B CG1 1 ATOM 4388 C CG2 . ILE B 1 11 ? 29.378 8.492 26.867 1.00 50.74 ? 11 ILE B CG2 1 ATOM 4389 C CD1 . ILE B 1 11 ? 28.058 10.695 28.781 1.00 56.47 ? 11 ILE B CD1 1 ATOM 4390 N N . THR B 1 12 ? 32.944 7.291 27.121 1.00 50.35 ? 12 THR B N 1 ATOM 4391 C CA . THR B 1 12 ? 33.962 6.848 26.164 1.00 51.60 ? 12 THR B CA 1 ATOM 4392 C C . THR B 1 12 ? 33.391 6.050 24.960 1.00 59.81 ? 12 THR B C 1 ATOM 4393 O O . THR B 1 12 ? 32.436 5.284 25.139 1.00 59.72 ? 12 THR B O 1 ATOM 4394 C CB . THR B 1 12 ? 35.052 6.054 26.907 1.00 56.43 ? 12 THR B CB 1 ATOM 4395 O OG1 . THR B 1 12 ? 34.490 4.849 27.415 1.00 54.75 ? 12 THR B OG1 1 ATOM 4396 C CG2 . THR B 1 12 ? 35.674 6.842 28.061 1.00 54.35 ? 12 THR B CG2 1 ATOM 4397 N N . PRO B 1 13 ? 33.967 6.169 23.734 1.00 58.92 ? 13 PRO B N 1 ATOM 4398 C CA . PRO B 1 13 ? 33.432 5.379 22.609 1.00 59.69 ? 13 PRO B CA 1 ATOM 4399 C C . PRO B 1 13 ? 33.957 3.940 22.590 1.00 65.78 ? 13 PRO B C 1 ATOM 4400 O O . PRO B 1 13 ? 34.740 3.557 23.462 1.00 65.96 ? 13 PRO B O 1 ATOM 4401 C CB . PRO B 1 13 ? 33.912 6.159 21.382 1.00 61.25 ? 13 PRO B CB 1 ATOM 4402 C CG . PRO B 1 13 ? 35.190 6.790 21.816 1.00 64.94 ? 13 PRO B CG 1 ATOM 4403 C CD . PRO B 1 13 ? 35.105 7.016 23.306 1.00 60.28 ? 13 PRO B CD 1 ATOM 4404 N N . CYS B 1 14 ? 33.546 3.151 21.579 1.00 63.16 ? 14 CYS B N 1 ATOM 4405 C CA . CYS B 1 14 ? 34.015 1.776 21.404 1.00 63.16 ? 14 CYS B CA 1 ATOM 4406 C C . CYS B 1 14 ? 35.091 1.747 20.332 1.00 64.75 ? 14 CYS B C 1 ATOM 4407 O O . CYS B 1 14 ? 36.216 1.317 20.594 1.00 64.09 ? 14 CYS B O 1 ATOM 4408 C CB . CYS B 1 14 ? 32.858 0.846 21.061 1.00 64.16 ? 14 CYS B CB 1 ATOM 4409 S SG . CYS B 1 14 ? 31.576 0.785 22.327 1.00 68.67 ? 14 CYS B SG 1 ATOM 4410 N N . ALA B 1 15 ? 34.746 2.241 19.130 1.00 60.00 ? 15 ALA B N 1 ATOM 4411 C CA . ALA B 1 15 ? 35.636 2.301 17.979 1.00 58.85 ? 15 ALA B CA 1 ATOM 4412 C C . ALA B 1 15 ? 35.981 3.746 17.608 1.00 61.54 ? 15 ALA B C 1 ATOM 4413 O O . ALA B 1 15 ? 35.785 4.671 18.410 1.00 59.86 ? 15 ALA B O 1 ATOM 4414 C CB . ALA B 1 15 ? 35.007 1.577 16.794 1.00 59.27 ? 15 ALA B CB 1 ATOM 4415 N N . ALA B 1 16 ? 36.549 3.918 16.395 1.00 58.21 ? 16 ALA B N 1 ATOM 4416 C CA . ALA B 1 16 ? 36.945 5.199 15.819 1.00 57.11 ? 16 ALA B CA 1 ATOM 4417 C C . ALA B 1 16 ? 35.697 6.035 15.599 1.00 57.16 ? 16 ALA B C 1 ATOM 4418 O O . ALA B 1 16 ? 34.630 5.496 15.293 1.00 57.01 ? 16 ALA B O 1 ATOM 4419 C CB . ALA B 1 16 ? 37.656 4.969 14.492 1.00 57.89 ? 16 ALA B CB 1 ATOM 4420 N N . GLU B 1 17 ? 35.822 7.338 15.795 1.00 50.39 ? 17 GLU B N 1 ATOM 4421 C CA . GLU B 1 17 ? 34.710 8.247 15.616 1.00 48.98 ? 17 GLU B CA 1 ATOM 4422 C C . GLU B 1 17 ? 35.052 9.251 14.528 1.00 52.54 ? 17 GLU B C 1 ATOM 4423 O O . GLU B 1 17 ? 36.168 9.773 14.504 1.00 52.30 ? 17 GLU B O 1 ATOM 4424 C CB . GLU B 1 17 ? 34.338 8.921 16.950 1.00 49.77 ? 17 GLU B CB 1 ATOM 4425 C CG . GLU B 1 17 ? 33.673 7.965 17.933 1.00 51.72 ? 17 GLU B CG 1 ATOM 4426 C CD . GLU B 1 17 ? 32.905 8.606 19.071 1.00 59.77 ? 17 GLU B CD 1 ATOM 4427 O OE1 . GLU B 1 17 ? 33.537 9.287 19.910 1.00 33.86 ? 17 GLU B OE1 1 ATOM 4428 O OE2 . GLU B 1 17 ? 31.676 8.380 19.155 1.00 52.90 ? 17 GLU B OE2 1 ATOM 4429 N N . GLU B 1 18 ? 34.108 9.485 13.605 1.00 48.36 ? 18 GLU B N 1 ATOM 4430 C CA . GLU B 1 18 ? 34.275 10.426 12.501 1.00 47.64 ? 18 GLU B CA 1 ATOM 4431 C C . GLU B 1 18 ? 33.282 11.586 12.637 1.00 51.86 ? 18 GLU B C 1 ATOM 4432 O O . GLU B 1 18 ? 32.070 11.365 12.643 1.00 51.77 ? 18 GLU B O 1 ATOM 4433 C CB . GLU B 1 18 ? 34.077 9.716 11.153 1.00 48.64 ? 18 GLU B CB 1 ATOM 4434 C CG . GLU B 1 18 ? 35.223 8.808 10.730 1.00 55.83 ? 18 GLU B CG 1 ATOM 4435 C CD . GLU B 1 18 ? 35.060 8.241 9.327 1.00 70.39 ? 18 GLU B CD 1 ATOM 4436 O OE1 . GLU B 1 18 ? 34.060 7.526 9.083 1.00 65.09 ? 18 GLU B OE1 1 ATOM 4437 O OE2 . GLU B 1 18 ? 35.926 8.521 8.468 1.00 50.94 ? 18 GLU B OE2 1 ATOM 4438 N N . SER B 1 19 ? 33.787 12.816 12.754 1.00 48.48 ? 19 SER B N 1 ATOM 4439 C CA . SER B 1 19 ? 32.921 13.991 12.844 1.00 49.05 ? 19 SER B CA 1 ATOM 4440 C C . SER B 1 19 ? 32.706 14.626 11.458 1.00 53.12 ? 19 SER B C 1 ATOM 4441 O O . SER B 1 19 ? 31.585 15.024 11.135 1.00 52.36 ? 19 SER B O 1 ATOM 4442 C CB . SER B 1 19 ? 33.468 15.006 13.846 1.00 53.87 ? 19 SER B CB 1 ATOM 4443 O OG . SER B 1 19 ? 34.821 15.350 13.594 1.00 67.67 ? 19 SER B OG 1 ATOM 4444 N N . LYS B 1 20 ? 33.780 14.687 10.638 1.00 49.55 ? 20 LYS B N 1 ATOM 4445 C CA . LYS B 1 20 ? 33.774 15.252 9.286 1.00 48.83 ? 20 LYS B CA 1 ATOM 4446 C C . LYS B 1 20 ? 33.181 14.283 8.264 1.00 49.99 ? 20 LYS B C 1 ATOM 4447 O O . LYS B 1 20 ? 33.455 13.083 8.334 1.00 49.63 ? 20 LYS B O 1 ATOM 4448 C CB . LYS B 1 20 ? 35.191 15.688 8.879 1.00 51.60 ? 20 LYS B CB 1 ATOM 4449 C CG . LYS B 1 20 ? 35.676 16.900 9.669 1.00 76.29 ? 20 LYS B CG 1 ATOM 4450 C CD . LYS B 1 20 ? 37.112 17.237 9.387 1.00 92.85 ? 20 LYS B CD 1 ATOM 4451 C CE . LYS B 1 20 ? 37.398 18.699 9.675 1.00 105.04 ? 20 LYS B CE 1 ATOM 4452 N NZ . LYS B 1 20 ? 38.684 19.151 9.074 1.00 113.60 ? 20 LYS B NZ 1 ATOM 4453 N N . LEU B 1 21 ? 32.384 14.816 7.312 1.00 44.46 ? 21 LEU B N 1 ATOM 4454 C CA . LEU B 1 21 ? 31.731 14.060 6.236 1.00 43.71 ? 21 LEU B CA 1 ATOM 4455 C C . LEU B 1 21 ? 32.740 13.321 5.319 1.00 47.90 ? 21 LEU B C 1 ATOM 4456 O O . LEU B 1 21 ? 33.504 13.978 4.607 1.00 47.16 ? 21 LEU B O 1 ATOM 4457 C CB . LEU B 1 21 ? 30.792 14.975 5.404 1.00 43.04 ? 21 LEU B CB 1 ATOM 4458 C CG . LEU B 1 21 ? 30.115 14.375 4.159 1.00 45.43 ? 21 LEU B CG 1 ATOM 4459 C CD1 . LEU B 1 21 ? 29.058 13.347 4.528 1.00 44.71 ? 21 LEU B CD1 1 ATOM 4460 C CD2 . LEU B 1 21 ? 29.495 15.454 3.318 1.00 46.05 ? 21 LEU B CD2 1 ATOM 4461 N N . PRO B 1 22 ? 32.729 11.960 5.310 1.00 44.73 ? 22 PRO B N 1 ATOM 4462 C CA . PRO B 1 22 ? 33.666 11.213 4.457 1.00 43.96 ? 22 PRO B CA 1 ATOM 4463 C C . PRO B 1 22 ? 33.298 11.371 2.991 1.00 46.57 ? 22 PRO B C 1 ATOM 4464 O O . PRO B 1 22 ? 32.135 11.204 2.609 1.00 45.69 ? 22 PRO B O 1 ATOM 4465 C CB . PRO B 1 22 ? 33.503 9.766 4.939 1.00 45.95 ? 22 PRO B CB 1 ATOM 4466 C CG . PRO B 1 22 ? 32.797 9.876 6.267 1.00 50.90 ? 22 PRO B CG 1 ATOM 4467 C CD . PRO B 1 22 ? 31.886 11.028 6.081 1.00 46.47 ? 22 PRO B CD 1 ATOM 4468 N N . ILE B 1 23 ? 34.290 11.759 2.187 1.00 42.48 ? 23 ILE B N 1 ATOM 4469 C CA . ILE B 1 23 ? 34.133 12.023 0.757 1.00 41.84 ? 23 ILE B CA 1 ATOM 4470 C C . ILE B 1 23 ? 34.657 10.852 -0.084 1.00 48.24 ? 23 ILE B C 1 ATOM 4471 O O . ILE B 1 23 ? 35.735 10.303 0.192 1.00 49.37 ? 23 ILE B O 1 ATOM 4472 C CB . ILE B 1 23 ? 34.788 13.395 0.388 1.00 43.87 ? 23 ILE B CB 1 ATOM 4473 C CG1 . ILE B 1 23 ? 34.215 14.582 1.222 1.00 43.19 ? 23 ILE B CG1 1 ATOM 4474 C CG2 . ILE B 1 23 ? 34.752 13.701 -1.101 1.00 44.68 ? 23 ILE B CG2 1 ATOM 4475 C CD1 . ILE B 1 23 ? 32.702 14.679 1.378 1.00 41.79 ? 23 ILE B CD1 1 ATOM 4476 N N . ASN B 1 24 ? 33.857 10.461 -1.091 1.00 44.00 ? 24 ASN B N 1 ATOM 4477 C CA . ASN B 1 24 ? 34.156 9.414 -2.065 1.00 43.19 ? 24 ASN B CA 1 ATOM 4478 C C . ASN B 1 24 ? 33.841 9.965 -3.481 1.00 45.50 ? 24 ASN B C 1 ATOM 4479 O O . ASN B 1 24 ? 33.660 11.177 -3.594 1.00 45.21 ? 24 ASN B O 1 ATOM 4480 C CB . ASN B 1 24 ? 33.449 8.090 -1.702 1.00 41.60 ? 24 ASN B CB 1 ATOM 4481 C CG . ASN B 1 24 ? 32.031 7.889 -2.181 1.00 59.49 ? 24 ASN B CG 1 ATOM 4482 O OD1 . ASN B 1 24 ? 31.361 8.795 -2.699 1.00 53.92 ? 24 ASN B OD1 1 ATOM 4483 N ND2 . ASN B 1 24 ? 31.551 6.665 -2.024 1.00 45.97 ? 24 ASN B ND2 1 ATOM 4484 N N . ALA B 1 25 ? 33.837 9.125 -4.549 1.00 39.96 ? 25 ALA B N 1 ATOM 4485 C CA . ALA B 1 25 ? 33.559 9.592 -5.919 1.00 38.78 ? 25 ALA B CA 1 ATOM 4486 C C . ALA B 1 25 ? 32.098 10.068 -6.131 1.00 42.11 ? 25 ALA B C 1 ATOM 4487 O O . ALA B 1 25 ? 31.857 11.036 -6.870 1.00 41.38 ? 25 ALA B O 1 ATOM 4488 C CB . ALA B 1 25 ? 33.917 8.515 -6.930 1.00 39.04 ? 25 ALA B CB 1 ATOM 4489 N N . LEU B 1 26 ? 31.142 9.406 -5.441 1.00 37.08 ? 26 LEU B N 1 ATOM 4490 C CA . LEU B 1 26 ? 29.702 9.659 -5.531 1.00 36.04 ? 26 LEU B CA 1 ATOM 4491 C C . LEU B 1 26 ? 29.219 10.867 -4.713 1.00 38.42 ? 26 LEU B C 1 ATOM 4492 O O . LEU B 1 26 ? 28.087 11.322 -4.907 1.00 37.43 ? 26 LEU B O 1 ATOM 4493 C CB . LEU B 1 26 ? 28.939 8.394 -5.097 1.00 35.98 ? 26 LEU B CB 1 ATOM 4494 C CG . LEU B 1 26 ? 29.350 7.087 -5.748 1.00 39.61 ? 26 LEU B CG 1 ATOM 4495 C CD1 . LEU B 1 26 ? 28.899 5.904 -4.938 1.00 38.81 ? 26 LEU B CD1 1 ATOM 4496 C CD2 . LEU B 1 26 ? 28.838 7.004 -7.151 1.00 42.83 ? 26 LEU B CD2 1 ATOM 4497 N N . SER B 1 27 ? 30.070 11.378 -3.806 1.00 34.46 ? 27 SER B N 1 ATOM 4498 C CA . SER B 1 27 ? 29.770 12.492 -2.901 1.00 33.65 ? 27 SER B CA 1 ATOM 4499 C C . SER B 1 27 ? 29.292 13.751 -3.599 1.00 37.90 ? 27 SER B C 1 ATOM 4500 O O . SER B 1 27 ? 28.224 14.251 -3.255 1.00 38.09 ? 27 SER B O 1 ATOM 4501 C CB . SER B 1 27 ? 30.967 12.806 -2.009 1.00 36.32 ? 27 SER B CB 1 ATOM 4502 O OG . SER B 1 27 ? 31.372 11.664 -1.276 1.00 43.29 ? 27 SER B OG 1 ATOM 4503 N N . ASN B 1 28 ? 30.062 14.238 -4.592 1.00 35.02 ? 28 ASN B N 1 ATOM 4504 C CA . ASN B 1 28 ? 29.789 15.461 -5.338 1.00 35.59 ? 28 ASN B CA 1 ATOM 4505 C C . ASN B 1 28 ? 28.550 15.412 -6.229 1.00 42.45 ? 28 ASN B C 1 ATOM 4506 O O . ASN B 1 28 ? 28.003 16.476 -6.540 1.00 43.96 ? 28 ASN B O 1 ATOM 4507 C CB . ASN B 1 28 ? 31.010 15.884 -6.135 1.00 36.93 ? 28 ASN B CB 1 ATOM 4508 C CG . ASN B 1 28 ? 32.155 16.358 -5.274 1.00 48.51 ? 28 ASN B CG 1 ATOM 4509 O OD1 . ASN B 1 28 ? 31.986 16.703 -4.106 1.00 35.30 ? 28 ASN B OD1 1 ATOM 4510 N ND2 . ASN B 1 28 ? 33.349 16.383 -5.839 1.00 44.03 ? 28 ASN B ND2 1 ATOM 4511 N N . SER B 1 29 ? 28.071 14.212 -6.602 1.00 39.33 ? 29 SER B N 1 ATOM 4512 C CA . SER B 1 29 ? 26.858 14.087 -7.420 1.00 39.68 ? 29 SER B CA 1 ATOM 4513 C C . SER B 1 29 ? 25.598 14.343 -6.586 1.00 45.49 ? 29 SER B C 1 ATOM 4514 O O . SER B 1 29 ? 24.496 14.435 -7.131 1.00 45.45 ? 29 SER B O 1 ATOM 4515 C CB . SER B 1 29 ? 26.801 12.731 -8.124 1.00 43.20 ? 29 SER B CB 1 ATOM 4516 O OG . SER B 1 29 ? 26.721 11.653 -7.208 1.00 53.73 ? 29 SER B OG 1 ATOM 4517 N N . LEU B 1 30 ? 25.777 14.468 -5.254 1.00 42.55 ? 30 LEU B N 1 ATOM 4518 C CA . LEU B 1 30 ? 24.721 14.719 -4.280 1.00 41.50 ? 30 LEU B CA 1 ATOM 4519 C C . LEU B 1 30 ? 24.968 16.029 -3.511 1.00 46.93 ? 30 LEU B C 1 ATOM 4520 O O . LEU B 1 30 ? 24.084 16.869 -3.425 1.00 47.57 ? 30 LEU B O 1 ATOM 4521 C CB . LEU B 1 30 ? 24.596 13.506 -3.303 1.00 40.67 ? 30 LEU B CB 1 ATOM 4522 C CG . LEU B 1 30 ? 23.541 13.582 -2.160 1.00 43.80 ? 30 LEU B CG 1 ATOM 4523 C CD1 . LEU B 1 30 ? 22.129 13.762 -2.685 1.00 43.02 ? 30 LEU B CD1 1 ATOM 4524 C CD2 . LEU B 1 30 ? 23.578 12.360 -1.291 1.00 44.13 ? 30 LEU B CD2 1 ATOM 4525 N N . LEU B 1 31 ? 26.147 16.196 -2.938 1.00 43.82 ? 31 LEU B N 1 ATOM 4526 C CA . LEU B 1 31 ? 26.415 17.337 -2.078 1.00 44.07 ? 31 LEU B CA 1 ATOM 4527 C C . LEU B 1 31 ? 27.743 17.985 -2.412 1.00 48.16 ? 31 LEU B C 1 ATOM 4528 O O . LEU B 1 31 ? 28.734 17.289 -2.636 1.00 48.08 ? 31 LEU B O 1 ATOM 4529 C CB . LEU B 1 31 ? 26.422 16.814 -0.624 1.00 44.11 ? 31 LEU B CB 1 ATOM 4530 C CG . LEU B 1 31 ? 26.149 17.803 0.487 1.00 49.06 ? 31 LEU B CG 1 ATOM 4531 C CD1 . LEU B 1 31 ? 24.952 17.379 1.310 1.00 49.39 ? 31 LEU B CD1 1 ATOM 4532 C CD2 . LEU B 1 31 ? 27.330 17.900 1.387 1.00 50.96 ? 31 LEU B CD2 1 ATOM 4533 N N . ARG B 1 32 ? 27.771 19.316 -2.422 1.00 44.52 ? 32 ARG B N 1 ATOM 4534 C CA . ARG B 1 32 ? 29.013 20.038 -2.680 1.00 44.88 ? 32 ARG B CA 1 ATOM 4535 C C . ARG B 1 32 ? 29.537 20.722 -1.414 1.00 46.61 ? 32 ARG B C 1 ATOM 4536 O O . ARG B 1 32 ? 30.735 20.623 -1.132 1.00 45.27 ? 32 ARG B O 1 ATOM 4537 C CB . ARG B 1 32 ? 28.891 21.002 -3.871 1.00 48.53 ? 32 ARG B CB 1 ATOM 4538 C CG . ARG B 1 32 ? 28.699 20.276 -5.207 1.00 64.58 ? 32 ARG B CG 1 ATOM 4539 C CD . ARG B 1 32 ? 29.154 21.112 -6.388 1.00 80.24 ? 32 ARG B CD 1 ATOM 4540 N NE . ARG B 1 32 ? 29.480 20.277 -7.551 1.00 93.44 ? 32 ARG B NE 1 ATOM 4541 C CZ . ARG B 1 32 ? 30.715 19.935 -7.913 1.00 100.79 ? 32 ARG B CZ 1 ATOM 4542 N NH1 . ARG B 1 32 ? 31.762 20.358 -7.214 1.00 88.38 ? 32 ARG B NH1 1 ATOM 4543 N NH2 . ARG B 1 32 ? 30.912 19.173 -8.983 1.00 75.68 ? 32 ARG B NH2 1 ATOM 4544 N N . HIS B 1 33 ? 28.632 21.331 -0.609 1.00 41.92 ? 33 HIS B N 1 ATOM 4545 C CA . HIS B 1 33 ? 28.997 22.011 0.645 1.00 40.75 ? 33 HIS B CA 1 ATOM 4546 C C . HIS B 1 33 ? 29.152 21.012 1.772 1.00 40.85 ? 33 HIS B C 1 ATOM 4547 O O . HIS B 1 33 ? 28.284 20.896 2.636 1.00 39.58 ? 33 HIS B O 1 ATOM 4548 C CB . HIS B 1 33 ? 28.020 23.156 0.984 1.00 41.76 ? 33 HIS B CB 1 ATOM 4549 C CG . HIS B 1 33 ? 27.691 24.046 -0.178 1.00 45.28 ? 33 HIS B CG 1 ATOM 4550 N ND1 . HIS B 1 33 ? 26.448 24.614 -0.310 1.00 46.89 ? 33 HIS B ND1 1 ATOM 4551 C CD2 . HIS B 1 33 ? 28.449 24.405 -1.243 1.00 47.58 ? 33 HIS B CD2 1 ATOM 4552 C CE1 . HIS B 1 33 ? 26.490 25.317 -1.430 1.00 46.77 ? 33 HIS B CE1 1 ATOM 4553 N NE2 . HIS B 1 33 ? 27.669 25.207 -2.034 1.00 47.31 ? 33 HIS B NE2 1 ATOM 4554 N N . HIS B 1 34 ? 30.264 20.254 1.716 1.00 36.56 ? 34 HIS B N 1 ATOM 4555 C CA . HIS B 1 34 ? 30.645 19.170 2.631 1.00 35.77 ? 34 HIS B CA 1 ATOM 4556 C C . HIS B 1 34 ? 30.853 19.597 4.074 1.00 40.31 ? 34 HIS B C 1 ATOM 4557 O O . HIS B 1 34 ? 30.575 18.816 4.978 1.00 38.42 ? 34 HIS B O 1 ATOM 4558 C CB . HIS B 1 34 ? 31.882 18.429 2.120 1.00 35.73 ? 34 HIS B CB 1 ATOM 4559 C CG . HIS B 1 34 ? 31.750 17.904 0.725 1.00 39.30 ? 34 HIS B CG 1 ATOM 4560 N ND1 . HIS B 1 34 ? 32.835 17.877 -0.138 1.00 41.26 ? 34 HIS B ND1 1 ATOM 4561 C CD2 . HIS B 1 34 ? 30.679 17.368 0.091 1.00 40.90 ? 34 HIS B CD2 1 ATOM 4562 C CE1 . HIS B 1 34 ? 32.386 17.344 -1.264 1.00 40.39 ? 34 HIS B CE1 1 ATOM 4563 N NE2 . HIS B 1 34 ? 31.097 17.018 -1.175 1.00 40.53 ? 34 HIS B NE2 1 ATOM 4564 N N . ASN B 1 35 ? 31.341 20.833 4.285 1.00 39.23 ? 35 ASN B N 1 ATOM 4565 C CA . ASN B 1 35 ? 31.619 21.418 5.602 1.00 39.64 ? 35 ASN B CA 1 ATOM 4566 C C . ASN B 1 35 ? 30.340 21.657 6.411 1.00 45.19 ? 35 ASN B C 1 ATOM 4567 O O . ASN B 1 35 ? 30.406 21.805 7.638 1.00 47.71 ? 35 ASN B O 1 ATOM 4568 C CB . ASN B 1 35 ? 32.445 22.706 5.455 1.00 42.51 ? 35 ASN B CB 1 ATOM 4569 C CG . ASN B 1 35 ? 33.627 22.561 4.511 1.00 86.65 ? 35 ASN B CG 1 ATOM 4570 O OD1 . ASN B 1 35 ? 34.471 21.660 4.649 1.00 84.78 ? 35 ASN B OD1 1 ATOM 4571 N ND2 . ASN B 1 35 ? 33.690 23.420 3.498 1.00 83.82 ? 35 ASN B ND2 1 ATOM 4572 N N A MET B 1 36 ? 29.181 21.670 5.728 0.50 40.80 ? 36 MET B N 1 ATOM 4573 N N B MET B 1 36 ? 29.186 21.670 5.735 0.50 40.77 ? 36 MET B N 1 ATOM 4574 C CA A MET B 1 36 ? 27.860 21.856 6.325 0.50 40.17 ? 36 MET B CA 1 ATOM 4575 C CA B MET B 1 36 ? 27.883 21.869 6.358 0.50 40.13 ? 36 MET B CA 1 ATOM 4576 C C A MET B 1 36 ? 27.428 20.613 7.097 0.50 43.22 ? 36 MET B C 1 ATOM 4577 C C B MET B 1 36 ? 27.419 20.612 7.097 0.50 43.19 ? 36 MET B C 1 ATOM 4578 O O A MET B 1 36 ? 26.761 20.735 8.122 0.50 43.12 ? 36 MET B O 1 ATOM 4579 O O B MET B 1 36 ? 26.739 20.727 8.113 0.50 43.07 ? 36 MET B O 1 ATOM 4580 C CB A MET B 1 36 ? 26.819 22.161 5.236 0.50 42.51 ? 36 MET B CB 1 ATOM 4581 C CB B MET B 1 36 ? 26.855 22.291 5.308 0.50 42.47 ? 36 MET B CB 1 ATOM 4582 C CG A MET B 1 36 ? 27.004 23.499 4.561 0.50 46.24 ? 36 MET B CG 1 ATOM 4583 C CG B MET B 1 36 ? 27.137 23.647 4.714 0.50 46.22 ? 36 MET B CG 1 ATOM 4584 S SD A MET B 1 36 ? 26.817 24.898 5.688 0.50 50.87 ? 36 MET B SD 1 ATOM 4585 S SD B MET B 1 36 ? 25.639 24.504 4.210 0.50 50.85 ? 36 MET B SD 1 ATOM 4586 C CE A MET B 1 36 ? 25.023 24.944 5.878 0.50 47.71 ? 36 MET B CE 1 ATOM 4587 C CE B MET B 1 36 ? 24.967 24.986 5.824 0.50 47.70 ? 36 MET B CE 1 ATOM 4588 N N . VAL B 1 37 ? 27.790 19.423 6.586 1.00 38.89 ? 37 VAL B N 1 ATOM 4589 C CA . VAL B 1 37 ? 27.439 18.118 7.150 1.00 38.09 ? 37 VAL B CA 1 ATOM 4590 C C . VAL B 1 37 ? 28.486 17.642 8.137 1.00 43.64 ? 37 VAL B C 1 ATOM 4591 O O . VAL B 1 37 ? 29.678 17.651 7.840 1.00 43.66 ? 37 VAL B O 1 ATOM 4592 C CB . VAL B 1 37 ? 27.153 17.076 6.032 1.00 41.30 ? 37 VAL B CB 1 ATOM 4593 C CG1 . VAL B 1 37 ? 26.959 15.668 6.597 1.00 40.49 ? 37 VAL B CG1 1 ATOM 4594 C CG2 . VAL B 1 37 ? 25.945 17.498 5.188 1.00 41.05 ? 37 VAL B CG2 1 ATOM 4595 N N . TYR B 1 38 ? 28.018 17.209 9.313 1.00 42.00 ? 38 TYR B N 1 ATOM 4596 C CA . TYR B 1 38 ? 28.833 16.692 10.411 1.00 42.07 ? 38 TYR B CA 1 ATOM 4597 C C . TYR B 1 38 ? 28.114 15.542 11.099 1.00 45.18 ? 38 TYR B C 1 ATOM 4598 O O . TYR B 1 38 ? 26.887 15.426 10.980 1.00 45.04 ? 38 TYR B O 1 ATOM 4599 C CB . TYR B 1 38 ? 29.125 17.819 11.434 1.00 43.19 ? 38 TYR B CB 1 ATOM 4600 C CG . TYR B 1 38 ? 27.932 18.237 12.273 1.00 44.16 ? 38 TYR B CG 1 ATOM 4601 C CD1 . TYR B 1 38 ? 26.979 19.121 11.775 1.00 45.94 ? 38 TYR B CD1 1 ATOM 4602 C CD2 . TYR B 1 38 ? 27.769 17.766 13.575 1.00 44.48 ? 38 TYR B CD2 1 ATOM 4603 C CE1 . TYR B 1 38 ? 25.878 19.502 12.542 1.00 46.89 ? 38 TYR B CE1 1 ATOM 4604 C CE2 . TYR B 1 38 ? 26.683 18.156 14.358 1.00 45.00 ? 38 TYR B CE2 1 ATOM 4605 C CZ . TYR B 1 38 ? 25.742 19.026 13.838 1.00 52.59 ? 38 TYR B CZ 1 ATOM 4606 O OH . TYR B 1 38 ? 24.673 19.410 14.603 1.00 52.87 ? 38 TYR B OH 1 ATOM 4607 N N . ALA B 1 39 ? 28.874 14.734 11.857 1.00 40.15 ? 39 ALA B N 1 ATOM 4608 C CA . ALA B 1 39 ? 28.349 13.656 12.680 1.00 39.96 ? 39 ALA B CA 1 ATOM 4609 C C . ALA B 1 39 ? 28.778 13.893 14.137 1.00 43.24 ? 39 ALA B C 1 ATOM 4610 O O . ALA B 1 39 ? 29.888 14.383 14.375 1.00 42.63 ? 39 ALA B O 1 ATOM 4611 C CB . ALA B 1 39 ? 28.849 12.312 12.187 1.00 40.57 ? 39 ALA B CB 1 ATOM 4612 N N . THR B 1 40 ? 27.898 13.571 15.104 1.00 38.92 ? 40 THR B N 1 ATOM 4613 C CA . THR B 1 40 ? 28.204 13.768 16.523 1.00 39.03 ? 40 THR B CA 1 ATOM 4614 C C . THR B 1 40 ? 29.071 12.620 17.081 1.00 46.50 ? 40 THR B C 1 ATOM 4615 O O . THR B 1 40 ? 28.936 11.474 16.640 1.00 46.72 ? 40 THR B O 1 ATOM 4616 C CB . THR B 1 40 ? 26.942 14.038 17.330 1.00 36.84 ? 40 THR B CB 1 ATOM 4617 O OG1 . THR B 1 40 ? 26.042 12.941 17.203 1.00 34.11 ? 40 THR B OG1 1 ATOM 4618 C CG2 . THR B 1 40 ? 26.260 15.316 16.914 1.00 32.96 ? 40 THR B CG2 1 ATOM 4619 N N . THR B 1 41 ? 30.030 12.975 17.982 1.00 43.91 ? 41 THR B N 1 ATOM 4620 C CA . THR B 1 41 ? 30.993 12.061 18.639 1.00 43.76 ? 41 THR B CA 1 ATOM 4621 C C . THR B 1 41 ? 30.852 12.085 20.172 1.00 48.49 ? 41 THR B C 1 ATOM 4622 O O . THR B 1 41 ? 29.975 12.772 20.697 1.00 47.68 ? 41 THR B O 1 ATOM 4623 C CB . THR B 1 41 ? 32.447 12.430 18.263 1.00 44.97 ? 41 THR B CB 1 ATOM 4624 O OG1 . THR B 1 41 ? 32.728 13.764 18.692 1.00 39.67 ? 41 THR B OG1 1 ATOM 4625 C CG2 . THR B 1 41 ? 32.742 12.246 16.792 1.00 41.50 ? 41 THR B CG2 1 ATOM 4626 N N . SER B 1 42 ? 31.743 11.366 20.888 1.00 46.78 ? 42 SER B N 1 ATOM 4627 C CA . SER B 1 42 ? 31.764 11.362 22.361 1.00 47.59 ? 42 SER B CA 1 ATOM 4628 C C . SER B 1 42 ? 32.390 12.654 22.937 1.00 51.36 ? 42 SER B C 1 ATOM 4629 O O . SER B 1 42 ? 32.238 12.926 24.125 1.00 52.09 ? 42 SER B O 1 ATOM 4630 C CB . SER B 1 42 ? 32.485 10.128 22.895 1.00 52.56 ? 42 SER B CB 1 ATOM 4631 O OG . SER B 1 42 ? 33.832 10.075 22.449 1.00 63.83 ? 42 SER B OG 1 ATOM 4632 N N . ARG B 1 43 ? 33.069 13.451 22.079 1.00 46.09 ? 43 ARG B N 1 ATOM 4633 C CA . ARG B 1 43 ? 33.737 14.709 22.410 1.00 44.52 ? 43 ARG B CA 1 ATOM 4634 C C . ARG B 1 43 ? 32.763 15.799 22.855 1.00 46.13 ? 43 ARG B C 1 ATOM 4635 O O . ARG B 1 43 ? 33.177 16.765 23.502 1.00 45.15 ? 43 ARG B O 1 ATOM 4636 C CB . ARG B 1 43 ? 34.551 15.199 21.200 1.00 44.71 ? 43 ARG B CB 1 ATOM 4637 C CG . ARG B 1 43 ? 35.857 14.452 20.994 1.00 53.12 ? 43 ARG B CG 1 ATOM 4638 C CD . ARG B 1 43 ? 36.640 14.957 19.792 1.00 58.93 ? 43 ARG B CD 1 ATOM 4639 N NE . ARG B 1 43 ? 36.171 14.386 18.523 1.00 62.99 ? 43 ARG B NE 1 ATOM 4640 C CZ . ARG B 1 43 ? 36.513 13.186 18.059 1.00 71.29 ? 43 ARG B CZ 1 ATOM 4641 N NH1 . ARG B 1 43 ? 37.314 12.396 18.764 1.00 59.13 ? 43 ARG B NH1 1 ATOM 4642 N NH2 . ARG B 1 43 ? 36.053 12.765 16.889 1.00 52.76 ? 43 ARG B NH2 1 ATOM 4643 N N . SER B 1 44 ? 31.482 15.664 22.495 1.00 42.58 ? 44 SER B N 1 ATOM 4644 C CA . SER B 1 44 ? 30.464 16.655 22.859 1.00 42.37 ? 44 SER B CA 1 ATOM 4645 C C . SER B 1 44 ? 29.557 16.193 24.000 1.00 46.00 ? 44 SER B C 1 ATOM 4646 O O . SER B 1 44 ? 28.682 16.966 24.405 1.00 45.46 ? 44 SER B O 1 ATOM 4647 C CB . SER B 1 44 ? 29.630 17.042 21.640 1.00 44.66 ? 44 SER B CB 1 ATOM 4648 O OG . SER B 1 44 ? 29.001 15.911 21.062 1.00 52.11 ? 44 SER B OG 1 ATOM 4649 N N . ALA B 1 45 ? 29.780 14.944 24.525 1.00 41.85 ? 45 ALA B N 1 ATOM 4650 C CA . ALA B 1 45 ? 28.978 14.289 25.579 1.00 41.66 ? 45 ALA B CA 1 ATOM 4651 C C . ALA B 1 45 ? 28.769 15.103 26.872 1.00 45.79 ? 45 ALA B C 1 ATOM 4652 O O . ALA B 1 45 ? 27.655 15.111 27.388 1.00 43.68 ? 45 ALA B O 1 ATOM 4653 C CB . ALA B 1 45 ? 29.544 12.922 25.913 1.00 42.20 ? 45 ALA B CB 1 ATOM 4654 N N . GLY B 1 46 ? 29.824 15.770 27.360 1.00 44.54 ? 46 GLY B N 1 ATOM 4655 C CA . GLY B 1 46 ? 29.801 16.599 28.565 1.00 45.13 ? 46 GLY B CA 1 ATOM 4656 C C . GLY B 1 46 ? 28.893 17.810 28.449 1.00 50.75 ? 46 GLY B C 1 ATOM 4657 O O . GLY B 1 46 ? 28.374 18.309 29.459 1.00 49.74 ? 46 GLY B O 1 ATOM 4658 N N . LEU B 1 47 ? 28.707 18.287 27.199 1.00 48.80 ? 47 LEU B N 1 ATOM 4659 C CA . LEU B 1 47 ? 27.823 19.392 26.843 1.00 49.12 ? 47 LEU B CA 1 ATOM 4660 C C . LEU B 1 47 ? 26.375 18.910 26.876 1.00 52.19 ? 47 LEU B C 1 ATOM 4661 O O . LEU B 1 47 ? 25.485 19.700 27.189 1.00 53.26 ? 47 LEU B O 1 ATOM 4662 C CB . LEU B 1 47 ? 28.177 19.947 25.465 1.00 49.45 ? 47 LEU B CB 1 ATOM 4663 C CG . LEU B 1 47 ? 29.106 21.134 25.515 1.00 54.71 ? 47 LEU B CG 1 ATOM 4664 C CD1 . LEU B 1 47 ? 30.319 20.932 24.621 1.00 54.54 ? 47 LEU B CD1 1 ATOM 4665 C CD2 . LEU B 1 47 ? 28.358 22.407 25.190 1.00 59.16 ? 47 LEU B CD2 1 ATOM 4666 N N . ARG B 1 48 ? 26.147 17.615 26.558 1.00 45.13 ? 48 ARG B N 1 ATOM 4667 C CA . ARG B 1 48 ? 24.848 16.968 26.616 1.00 43.26 ? 48 ARG B CA 1 ATOM 4668 C C . ARG B 1 48 ? 24.531 16.706 28.074 1.00 43.64 ? 48 ARG B C 1 ATOM 4669 O O . ARG B 1 48 ? 23.413 16.986 28.501 1.00 42.01 ? 48 ARG B O 1 ATOM 4670 C CB . ARG B 1 48 ? 24.848 15.664 25.799 1.00 43.84 ? 48 ARG B CB 1 ATOM 4671 C CG . ARG B 1 48 ? 23.523 14.880 25.814 1.00 53.52 ? 48 ARG B CG 1 ATOM 4672 C CD . ARG B 1 48 ? 22.311 15.678 25.344 1.00 58.16 ? 48 ARG B CD 1 ATOM 4673 N NE . ARG B 1 48 ? 22.386 16.087 23.942 1.00 63.57 ? 48 ARG B NE 1 ATOM 4674 C CZ . ARG B 1 48 ? 21.490 16.870 23.349 1.00 73.87 ? 48 ARG B CZ 1 ATOM 4675 N NH1 . ARG B 1 48 ? 20.449 17.332 24.029 1.00 61.84 ? 48 ARG B NH1 1 ATOM 4676 N NH2 . ARG B 1 48 ? 21.626 17.196 22.071 1.00 56.22 ? 48 ARG B NH2 1 ATOM 4677 N N . GLN B 1 49 ? 25.539 16.215 28.840 1.00 39.79 ? 49 GLN B N 1 ATOM 4678 C CA . GLN B 1 49 ? 25.500 15.918 30.280 1.00 39.19 ? 49 GLN B CA 1 ATOM 4679 C C . GLN B 1 49 ? 24.988 17.128 31.068 1.00 43.83 ? 49 GLN B C 1 ATOM 4680 O O . GLN B 1 49 ? 24.096 16.983 31.896 1.00 42.65 ? 49 GLN B O 1 ATOM 4681 C CB . GLN B 1 49 ? 26.890 15.529 30.794 1.00 39.95 ? 49 GLN B CB 1 ATOM 4682 C CG . GLN B 1 49 ? 27.249 14.057 30.648 1.00 51.14 ? 49 GLN B CG 1 ATOM 4683 C CD . GLN B 1 49 ? 28.465 13.691 31.495 1.00 73.39 ? 49 GLN B CD 1 ATOM 4684 O OE1 . GLN B 1 49 ? 29.228 14.546 31.978 1.00 73.15 ? 49 GLN B OE1 1 ATOM 4685 N NE2 . GLN B 1 49 ? 28.679 12.405 31.707 1.00 57.83 ? 49 GLN B NE2 1 ATOM 4686 N N . LYS B 1 50 ? 25.522 18.322 30.770 1.00 42.05 ? 50 LYS B N 1 ATOM 4687 C CA . LYS B 1 50 ? 25.094 19.569 31.394 1.00 42.59 ? 50 LYS B CA 1 ATOM 4688 C C . LYS B 1 50 ? 23.595 19.843 31.124 1.00 47.70 ? 50 LYS B C 1 ATOM 4689 O O . LYS B 1 50 ? 22.824 20.012 32.082 1.00 47.31 ? 50 LYS B O 1 ATOM 4690 C CB . LYS B 1 50 ? 26.000 20.733 30.948 1.00 44.96 ? 50 LYS B CB 1 ATOM 4691 C CG . LYS B 1 50 ? 27.229 20.859 31.839 1.00 60.36 ? 50 LYS B CG 1 ATOM 4692 C CD . LYS B 1 50 ? 28.473 21.286 31.077 1.00 71.90 ? 50 LYS B CD 1 ATOM 4693 C CE . LYS B 1 50 ? 29.736 21.003 31.862 1.00 83.66 ? 50 LYS B CE 1 ATOM 4694 N NZ . LYS B 1 50 ? 30.035 19.542 31.955 1.00 92.21 ? 50 LYS B NZ 1 ATOM 4695 N N . LYS B 1 51 ? 23.191 19.792 29.829 1.00 44.23 ? 51 LYS B N 1 ATOM 4696 C CA . LYS B 1 51 ? 21.827 20.001 29.318 1.00 44.52 ? 51 LYS B CA 1 ATOM 4697 C C . LYS B 1 51 ? 20.755 19.063 29.917 1.00 48.23 ? 51 LYS B C 1 ATOM 4698 O O . LYS B 1 51 ? 19.719 19.543 30.375 1.00 47.51 ? 51 LYS B O 1 ATOM 4699 C CB . LYS B 1 51 ? 21.800 19.894 27.778 1.00 47.74 ? 51 LYS B CB 1 ATOM 4700 C CG . LYS B 1 51 ? 22.590 20.981 27.059 1.00 71.66 ? 51 LYS B CG 1 ATOM 4701 C CD . LYS B 1 51 ? 22.436 20.908 25.544 1.00 84.16 ? 51 LYS B CD 1 ATOM 4702 C CE . LYS B 1 51 ? 23.146 22.041 24.834 1.00 96.88 ? 51 LYS B CE 1 ATOM 4703 N NZ . LYS B 1 51 ? 22.563 23.373 25.161 1.00 105.45 ? 51 LYS B NZ 1 ATOM 4704 N N . VAL B 1 52 ? 20.993 17.735 29.889 1.00 44.27 ? 52 VAL B N 1 ATOM 4705 C CA . VAL B 1 52 ? 20.056 16.714 30.378 1.00 43.49 ? 52 VAL B CA 1 ATOM 4706 C C . VAL B 1 52 ? 19.926 16.700 31.900 1.00 48.21 ? 52 VAL B C 1 ATOM 4707 O O . VAL B 1 52 ? 18.960 16.116 32.397 1.00 49.12 ? 52 VAL B O 1 ATOM 4708 C CB . VAL B 1 52 ? 20.359 15.284 29.834 1.00 47.20 ? 52 VAL B CB 1 ATOM 4709 C CG1 . VAL B 1 52 ? 20.219 15.212 28.322 1.00 46.87 ? 52 VAL B CG1 1 ATOM 4710 C CG2 . VAL B 1 52 ? 21.724 14.767 30.286 1.00 47.07 ? 52 VAL B CG2 1 ATOM 4711 N N . THR B 1 53 ? 20.907 17.302 32.639 1.00 43.19 ? 53 THR B N 1 ATOM 4712 C CA . THR B 1 53 ? 20.945 17.327 34.108 1.00 41.54 ? 53 THR B CA 1 ATOM 4713 C C . THR B 1 53 ? 20.217 18.524 34.716 1.00 42.87 ? 53 THR B C 1 ATOM 4714 O O . THR B 1 53 ? 20.683 19.655 34.631 1.00 43.58 ? 53 THR B O 1 ATOM 4715 C CB . THR B 1 53 ? 22.385 17.207 34.618 1.00 48.29 ? 53 THR B CB 1 ATOM 4716 O OG1 . THR B 1 53 ? 22.946 15.998 34.101 1.00 47.67 ? 53 THR B OG1 1 ATOM 4717 C CG2 . THR B 1 53 ? 22.471 17.199 36.141 1.00 44.71 ? 53 THR B CG2 1 ATOM 4718 N N . PHE B 1 54 ? 19.084 18.252 35.357 1.00 37.58 ? 54 PHE B N 1 ATOM 4719 C CA . PHE B 1 54 ? 18.257 19.240 36.048 1.00 36.78 ? 54 PHE B CA 1 ATOM 4720 C C . PHE B 1 54 ? 17.368 18.580 37.084 1.00 40.97 ? 54 PHE B C 1 ATOM 4721 O O . PHE B 1 54 ? 17.149 17.365 37.033 1.00 41.07 ? 54 PHE B O 1 ATOM 4722 C CB . PHE B 1 54 ? 17.435 20.108 35.079 1.00 38.30 ? 54 PHE B CB 1 ATOM 4723 C CG . PHE B 1 54 ? 16.596 19.374 34.062 1.00 39.11 ? 54 PHE B CG 1 ATOM 4724 C CD1 . PHE B 1 54 ? 15.288 19.008 34.350 1.00 41.26 ? 54 PHE B CD1 1 ATOM 4725 C CD2 . PHE B 1 54 ? 17.094 19.100 32.794 1.00 40.81 ? 54 PHE B CD2 1 ATOM 4726 C CE1 . PHE B 1 54 ? 14.497 18.365 33.395 1.00 42.11 ? 54 PHE B CE1 1 ATOM 4727 C CE2 . PHE B 1 54 ? 16.305 18.449 31.842 1.00 43.52 ? 54 PHE B CE2 1 ATOM 4728 C CZ . PHE B 1 54 ? 15.008 18.095 32.144 1.00 41.43 ? 54 PHE B CZ 1 ATOM 4729 N N . ASP B 1 55 ? 16.908 19.376 38.062 1.00 37.07 ? 55 ASP B N 1 ATOM 4730 C CA . ASP B 1 55 ? 16.033 18.927 39.142 1.00 36.01 ? 55 ASP B CA 1 ATOM 4731 C C . ASP B 1 55 ? 14.587 18.992 38.640 1.00 37.65 ? 55 ASP B C 1 ATOM 4732 O O . ASP B 1 55 ? 14.237 19.947 37.944 1.00 37.49 ? 55 ASP B O 1 ATOM 4733 C CB . ASP B 1 55 ? 16.259 19.797 40.394 1.00 37.66 ? 55 ASP B CB 1 ATOM 4734 C CG . ASP B 1 55 ? 15.557 19.330 41.655 1.00 53.31 ? 55 ASP B CG 1 ATOM 4735 O OD1 . ASP B 1 55 ? 15.849 18.195 42.123 1.00 52.45 ? 55 ASP B OD1 1 ATOM 4736 O OD2 . ASP B 1 55 ? 14.771 20.122 42.218 1.00 65.35 ? 55 ASP B OD2 1 ATOM 4737 N N . ARG B 1 56 ? 13.767 17.961 38.942 1.00 32.33 ? 56 ARG B N 1 ATOM 4738 C CA . ARG B 1 56 ? 12.372 17.913 38.497 1.00 31.84 ? 56 ARG B CA 1 ATOM 4739 C C . ARG B 1 56 ? 11.386 18.117 39.642 1.00 37.83 ? 56 ARG B C 1 ATOM 4740 O O . ARG B 1 56 ? 11.434 17.399 40.647 1.00 37.60 ? 56 ARG B O 1 ATOM 4741 C CB . ARG B 1 56 ? 12.050 16.613 37.725 1.00 29.41 ? 56 ARG B CB 1 ATOM 4742 C CG . ARG B 1 56 ? 12.661 16.497 36.315 1.00 31.92 ? 56 ARG B CG 1 ATOM 4743 C CD . ARG B 1 56 ? 14.084 15.919 36.274 1.00 34.58 ? 56 ARG B CD 1 ATOM 4744 N NE . ARG B 1 56 ? 14.364 14.953 37.349 1.00 39.83 ? 56 ARG B NE 1 ATOM 4745 C CZ . ARG B 1 56 ? 14.086 13.652 37.304 1.00 53.49 ? 56 ARG B CZ 1 ATOM 4746 N NH1 . ARG B 1 56 ? 13.528 13.123 36.224 1.00 39.58 ? 56 ARG B NH1 1 ATOM 4747 N NH2 . ARG B 1 56 ? 14.374 12.871 38.334 1.00 44.66 ? 56 ARG B NH2 1 ATOM 4748 N N . LEU B 1 57 ? 10.469 19.084 39.474 1.00 35.71 ? 57 LEU B N 1 ATOM 4749 C CA . LEU B 1 57 ? 9.439 19.386 40.465 1.00 35.74 ? 57 LEU B CA 1 ATOM 4750 C C . LEU B 1 57 ? 8.062 19.103 39.881 1.00 40.85 ? 57 LEU B C 1 ATOM 4751 O O . LEU B 1 57 ? 7.699 19.675 38.849 1.00 42.25 ? 57 LEU B O 1 ATOM 4752 C CB . LEU B 1 57 ? 9.572 20.832 41.025 1.00 35.75 ? 57 LEU B CB 1 ATOM 4753 C CG . LEU B 1 57 ? 10.851 21.198 41.866 1.00 39.42 ? 57 LEU B CG 1 ATOM 4754 C CD1 . LEU B 1 57 ? 11.324 20.033 42.777 1.00 38.86 ? 57 LEU B CD1 1 ATOM 4755 C CD2 . LEU B 1 57 ? 11.998 21.726 40.977 1.00 40.37 ? 57 LEU B CD2 1 ATOM 4756 N N . GLN B 1 58 ? 7.325 18.165 40.514 1.00 36.71 ? 58 GLN B N 1 ATOM 4757 C CA . GLN B 1 58 ? 6.008 17.694 40.075 1.00 36.05 ? 58 GLN B CA 1 ATOM 4758 C C . GLN B 1 58 ? 4.851 18.048 41.016 1.00 38.82 ? 58 GLN B C 1 ATOM 4759 O O . GLN B 1 58 ? 4.965 17.926 42.245 1.00 38.00 ? 58 GLN B O 1 ATOM 4760 C CB . GLN B 1 58 ? 6.045 16.185 39.850 1.00 37.24 ? 58 GLN B CB 1 ATOM 4761 C CG . GLN B 1 58 ? 5.464 15.768 38.509 1.00 40.64 ? 58 GLN B CG 1 ATOM 4762 C CD . GLN B 1 58 ? 5.738 14.323 38.171 1.00 43.69 ? 58 GLN B CD 1 ATOM 4763 O OE1 . GLN B 1 58 ? 6.203 13.518 38.995 1.00 36.18 ? 58 GLN B OE1 1 ATOM 4764 N NE2 . GLN B 1 58 ? 5.462 13.964 36.933 1.00 32.40 ? 58 GLN B NE2 1 ATOM 4765 N N . VAL B 1 59 ? 3.731 18.488 40.415 1.00 33.81 ? 59 VAL B N 1 ATOM 4766 C CA . VAL B 1 59 ? 2.513 18.886 41.115 1.00 33.20 ? 59 VAL B CA 1 ATOM 4767 C C . VAL B 1 59 ? 1.330 18.199 40.400 1.00 39.42 ? 59 VAL B C 1 ATOM 4768 O O . VAL B 1 59 ? 0.879 18.647 39.341 1.00 40.52 ? 59 VAL B O 1 ATOM 4769 C CB . VAL B 1 59 ? 2.387 20.432 41.232 1.00 36.05 ? 59 VAL B CB 1 ATOM 4770 C CG1 . VAL B 1 59 ? 1.047 20.829 41.801 1.00 36.08 ? 59 VAL B CG1 1 ATOM 4771 C CG2 . VAL B 1 59 ? 3.506 21.033 42.088 1.00 35.53 ? 59 VAL B CG2 1 ATOM 4772 N N . LEU B 1 60 ? 0.881 17.060 40.958 1.00 34.72 ? 60 LEU B N 1 ATOM 4773 C CA . LEU B 1 60 ? -0.182 16.242 40.384 1.00 33.04 ? 60 LEU B CA 1 ATOM 4774 C C . LEU B 1 60 ? -1.549 16.587 40.975 1.00 37.26 ? 60 LEU B C 1 ATOM 4775 O O . LEU B 1 60 ? -1.749 16.471 42.183 1.00 37.20 ? 60 LEU B O 1 ATOM 4776 C CB . LEU B 1 60 ? 0.137 14.745 40.527 1.00 32.35 ? 60 LEU B CB 1 ATOM 4777 C CG . LEU B 1 60 ? 1.521 14.254 40.081 1.00 36.03 ? 60 LEU B CG 1 ATOM 4778 C CD1 . LEU B 1 60 ? 1.693 12.800 40.410 1.00 35.98 ? 60 LEU B CD1 1 ATOM 4779 C CD2 . LEU B 1 60 ? 1.749 14.465 38.589 1.00 39.22 ? 60 LEU B CD2 1 ATOM 4780 N N . ASP B 1 61 ? -2.479 17.025 40.105 1.00 33.38 ? 61 ASP B N 1 ATOM 4781 C CA . ASP B 1 61 ? -3.830 17.445 40.458 1.00 33.26 ? 61 ASP B CA 1 ATOM 4782 C C . ASP B 1 61 ? -4.895 16.399 40.081 1.00 37.76 ? 61 ASP B C 1 ATOM 4783 O O . ASP B 1 61 ? -4.556 15.351 39.546 1.00 38.06 ? 61 ASP B O 1 ATOM 4784 C CB . ASP B 1 61 ? -4.127 18.806 39.800 1.00 34.89 ? 61 ASP B CB 1 ATOM 4785 C CG . ASP B 1 61 ? -4.377 18.738 38.313 1.00 42.01 ? 61 ASP B CG 1 ATOM 4786 O OD1 . ASP B 1 61 ? -3.777 17.870 37.649 1.00 41.20 ? 61 ASP B OD1 1 ATOM 4787 O OD2 . ASP B 1 61 ? -5.203 19.526 37.819 1.00 51.67 ? 61 ASP B OD2 1 ATOM 4788 N N . ASP B 1 62 ? -6.175 16.688 40.363 1.00 35.25 ? 62 ASP B N 1 ATOM 4789 C CA . ASP B 1 62 ? -7.297 15.785 40.097 1.00 35.58 ? 62 ASP B CA 1 ATOM 4790 C C . ASP B 1 62 ? -7.467 15.391 38.624 1.00 37.14 ? 62 ASP B C 1 ATOM 4791 O O . ASP B 1 62 ? -7.736 14.219 38.375 1.00 33.96 ? 62 ASP B O 1 ATOM 4792 C CB . ASP B 1 62 ? -8.606 16.336 40.671 1.00 37.90 ? 62 ASP B CB 1 ATOM 4793 C CG . ASP B 1 62 ? -8.651 16.380 42.189 1.00 53.40 ? 62 ASP B CG 1 ATOM 4794 O OD1 . ASP B 1 62 ? -7.872 15.636 42.837 1.00 53.97 ? 62 ASP B OD1 1 ATOM 4795 O OD2 . ASP B 1 62 ? -9.504 17.107 42.730 1.00 64.96 ? 62 ASP B OD2 1 ATOM 4796 N N . HIS B 1 63 ? -7.248 16.325 37.659 1.00 34.02 ? 63 HIS B N 1 ATOM 4797 C CA . HIS B 1 63 ? -7.344 16.013 36.222 1.00 33.11 ? 63 HIS B CA 1 ATOM 4798 C C . HIS B 1 63 ? -6.411 14.882 35.847 1.00 37.40 ? 63 HIS B C 1 ATOM 4799 O O . HIS B 1 63 ? -6.808 14.008 35.069 1.00 37.96 ? 63 HIS B O 1 ATOM 4800 C CB . HIS B 1 63 ? -7.028 17.223 35.345 1.00 33.16 ? 63 HIS B CB 1 ATOM 4801 C CG . HIS B 1 63 ? -8.087 18.279 35.350 1.00 36.42 ? 63 HIS B CG 1 ATOM 4802 N ND1 . HIS B 1 63 ? -9.406 17.994 35.007 1.00 37.89 ? 63 HIS B ND1 1 ATOM 4803 C CD2 . HIS B 1 63 ? -7.974 19.605 35.588 1.00 37.87 ? 63 HIS B CD2 1 ATOM 4804 C CE1 . HIS B 1 63 ? -10.045 19.145 35.073 1.00 37.18 ? 63 HIS B CE1 1 ATOM 4805 N NE2 . HIS B 1 63 ? -9.229 20.142 35.427 1.00 37.52 ? 63 HIS B NE2 1 ATOM 4806 N N . TYR B 1 64 ? -5.180 14.902 36.418 1.00 32.77 ? 64 TYR B N 1 ATOM 4807 C CA . TYR B 1 64 ? -4.109 13.918 36.237 1.00 32.88 ? 64 TYR B CA 1 ATOM 4808 C C . TYR B 1 64 ? -4.592 12.529 36.652 1.00 36.98 ? 64 TYR B C 1 ATOM 4809 O O . TYR B 1 64 ? -4.529 11.608 35.842 1.00 35.99 ? 64 TYR B O 1 ATOM 4810 C CB . TYR B 1 64 ? -2.842 14.332 37.037 1.00 34.02 ? 64 TYR B CB 1 ATOM 4811 C CG . TYR B 1 64 ? -1.709 13.335 36.961 1.00 35.94 ? 64 TYR B CG 1 ATOM 4812 C CD1 . TYR B 1 64 ? -0.762 13.402 35.939 1.00 37.99 ? 64 TYR B CD1 1 ATOM 4813 C CD2 . TYR B 1 64 ? -1.593 12.306 37.894 1.00 36.33 ? 64 TYR B CD2 1 ATOM 4814 C CE1 . TYR B 1 64 ? 0.277 12.476 35.852 1.00 37.99 ? 64 TYR B CE1 1 ATOM 4815 C CE2 . TYR B 1 64 ? -0.574 11.356 37.800 1.00 37.18 ? 64 TYR B CE2 1 ATOM 4816 C CZ . TYR B 1 64 ? 0.365 11.451 36.781 1.00 44.37 ? 64 TYR B CZ 1 ATOM 4817 O OH . TYR B 1 64 ? 1.386 10.539 36.686 1.00 44.51 ? 64 TYR B OH 1 ATOM 4818 N N . ARG B 1 65 ? -5.073 12.384 37.906 1.00 34.23 ? 65 ARG B N 1 ATOM 4819 C CA . ARG B 1 65 ? -5.588 11.118 38.456 1.00 33.60 ? 65 ARG B CA 1 ATOM 4820 C C . ARG B 1 65 ? -6.883 10.684 37.766 1.00 38.71 ? 65 ARG B C 1 ATOM 4821 O O . ARG B 1 65 ? -7.135 9.487 37.674 1.00 37.60 ? 65 ARG B O 1 ATOM 4822 C CB . ARG B 1 65 ? -5.790 11.215 39.976 1.00 30.08 ? 65 ARG B CB 1 ATOM 4823 C CG . ARG B 1 65 ? -4.494 11.369 40.749 1.00 26.02 ? 65 ARG B CG 1 ATOM 4824 C CD . ARG B 1 65 ? -4.735 11.599 42.219 1.00 22.98 ? 65 ARG B CD 1 ATOM 4825 N NE . ARG B 1 65 ? -5.160 12.964 42.538 1.00 32.08 ? 65 ARG B NE 1 ATOM 4826 C CZ . ARG B 1 65 ? -4.338 14.002 42.672 1.00 45.95 ? 65 ARG B CZ 1 ATOM 4827 N NH1 . ARG B 1 65 ? -3.032 13.859 42.462 1.00 34.89 ? 65 ARG B NH1 1 ATOM 4828 N NH2 . ARG B 1 65 ? -4.816 15.193 42.990 1.00 27.26 ? 65 ARG B NH2 1 ATOM 4829 N N . ASP B 1 66 ? -7.697 11.660 37.282 1.00 37.43 ? 66 ASP B N 1 ATOM 4830 C CA . ASP B 1 66 ? -8.950 11.430 36.545 1.00 38.22 ? 66 ASP B CA 1 ATOM 4831 C C . ASP B 1 66 ? -8.610 10.739 35.253 1.00 42.68 ? 66 ASP B C 1 ATOM 4832 O O . ASP B 1 66 ? -9.126 9.656 35.008 1.00 43.67 ? 66 ASP B O 1 ATOM 4833 C CB . ASP B 1 66 ? -9.705 12.744 36.238 1.00 40.61 ? 66 ASP B CB 1 ATOM 4834 C CG . ASP B 1 66 ? -10.477 13.403 37.378 1.00 51.67 ? 66 ASP B CG 1 ATOM 4835 O OD1 . ASP B 1 66 ? -10.556 12.803 38.486 1.00 50.28 ? 66 ASP B OD1 1 ATOM 4836 O OD2 . ASP B 1 66 ? -10.994 14.519 37.168 1.00 60.07 ? 66 ASP B OD2 1 ATOM 4837 N N . VAL B 1 67 ? -7.707 11.339 34.449 1.00 39.20 ? 67 VAL B N 1 ATOM 4838 C CA . VAL B 1 67 ? -7.229 10.774 33.179 1.00 39.20 ? 67 VAL B CA 1 ATOM 4839 C C . VAL B 1 67 ? -6.582 9.395 33.449 1.00 41.24 ? 67 VAL B C 1 ATOM 4840 O O . VAL B 1 67 ? -6.905 8.428 32.757 1.00 41.35 ? 67 VAL B O 1 ATOM 4841 C CB . VAL B 1 67 ? -6.271 11.751 32.428 1.00 43.94 ? 67 VAL B CB 1 ATOM 4842 C CG1 . VAL B 1 67 ? -5.608 11.085 31.219 1.00 43.88 ? 67 VAL B CG1 1 ATOM 4843 C CG2 . VAL B 1 67 ? -7.013 13.011 31.994 1.00 43.88 ? 67 VAL B CG2 1 ATOM 4844 N N . LEU B 1 68 ? -5.712 9.308 34.488 1.00 35.28 ? 68 LEU B N 1 ATOM 4845 C CA . LEU B 1 68 ? -5.027 8.079 34.872 1.00 33.76 ? 68 LEU B CA 1 ATOM 4846 C C . LEU B 1 68 ? -6.006 6.965 35.178 1.00 40.60 ? 68 LEU B C 1 ATOM 4847 O O . LEU B 1 68 ? -5.794 5.855 34.695 1.00 42.64 ? 68 LEU B O 1 ATOM 4848 C CB . LEU B 1 68 ? -4.053 8.305 36.041 1.00 32.57 ? 68 LEU B CB 1 ATOM 4849 C CG . LEU B 1 68 ? -3.287 7.091 36.589 1.00 34.88 ? 68 LEU B CG 1 ATOM 4850 C CD1 . LEU B 1 68 ? -2.491 6.373 35.494 1.00 35.07 ? 68 LEU B CD1 1 ATOM 4851 C CD2 . LEU B 1 68 ? -2.372 7.502 37.711 1.00 32.54 ? 68 LEU B CD2 1 ATOM 4852 N N . LYS B 1 69 ? -7.094 7.263 35.929 1.00 36.31 ? 69 LYS B N 1 ATOM 4853 C CA . LYS B 1 69 ? -8.134 6.292 36.297 1.00 35.45 ? 69 LYS B CA 1 ATOM 4854 C C . LYS B 1 69 ? -8.804 5.725 35.036 1.00 40.04 ? 69 LYS B C 1 ATOM 4855 O O . LYS B 1 69 ? -9.077 4.525 34.985 1.00 41.25 ? 69 LYS B O 1 ATOM 4856 C CB . LYS B 1 69 ? -9.180 6.932 37.224 1.00 36.53 ? 69 LYS B CB 1 ATOM 4857 C CG . LYS B 1 69 ? -9.965 5.898 38.012 1.00 39.61 ? 69 LYS B CG 1 ATOM 4858 C CD . LYS B 1 69 ? -11.202 6.446 38.673 1.00 38.66 ? 69 LYS B CD 1 ATOM 4859 C CE . LYS B 1 69 ? -11.948 5.315 39.333 1.00 48.06 ? 69 LYS B CE 1 ATOM 4860 N NZ . LYS B 1 69 ? -13.045 5.800 40.215 1.00 58.46 ? 69 LYS B NZ 1 ATOM 4861 N N . GLU B 1 70 ? -9.009 6.577 34.009 1.00 34.07 ? 70 GLU B N 1 ATOM 4862 C CA . GLU B 1 70 ? -9.588 6.198 32.724 1.00 33.40 ? 70 GLU B CA 1 ATOM 4863 C C . GLU B 1 70 ? -8.637 5.275 31.967 1.00 33.36 ? 70 GLU B C 1 ATOM 4864 O O . GLU B 1 70 ? -9.060 4.222 31.499 1.00 33.54 ? 70 GLU B O 1 ATOM 4865 C CB . GLU B 1 70 ? -9.874 7.443 31.863 1.00 35.30 ? 70 GLU B CB 1 ATOM 4866 C CG . GLU B 1 70 ? -10.820 8.449 32.498 1.00 45.82 ? 70 GLU B CG 1 ATOM 4867 C CD . GLU B 1 70 ? -11.182 9.638 31.638 1.00 60.88 ? 70 GLU B CD 1 ATOM 4868 O OE1 . GLU B 1 70 ? -10.676 9.729 30.496 1.00 56.94 ? 70 GLU B OE1 1 ATOM 4869 O OE2 . GLU B 1 70 ? -11.969 10.487 32.113 1.00 52.88 ? 70 GLU B OE2 1 ATOM 4870 N N . MET B 1 71 ? -7.361 5.680 31.841 1.00 26.29 ? 71 MET B N 1 ATOM 4871 C CA . MET B 1 71 ? -6.314 4.919 31.167 1.00 25.72 ? 71 MET B CA 1 ATOM 4872 C C . MET B 1 71 ? -6.175 3.519 31.787 1.00 28.31 ? 71 MET B C 1 ATOM 4873 O O . MET B 1 71 ? -6.155 2.534 31.044 1.00 26.16 ? 71 MET B O 1 ATOM 4874 C CB . MET B 1 71 ? -4.979 5.666 31.239 1.00 28.17 ? 71 MET B CB 1 ATOM 4875 C CG . MET B 1 71 ? -4.945 6.952 30.440 1.00 31.20 ? 71 MET B CG 1 ATOM 4876 S SD . MET B 1 71 ? -3.388 7.850 30.632 1.00 33.89 ? 71 MET B SD 1 ATOM 4877 C CE . MET B 1 71 ? -2.274 6.797 29.726 1.00 30.46 ? 71 MET B CE 1 ATOM 4878 N N . LYS B 1 72 ? -6.125 3.436 33.154 1.00 25.32 ? 72 LYS B N 1 ATOM 4879 C CA . LYS B 1 72 ? -6.066 2.185 33.943 1.00 24.44 ? 72 LYS B CA 1 ATOM 4880 C C . LYS B 1 72 ? -7.322 1.304 33.724 1.00 32.09 ? 72 LYS B C 1 ATOM 4881 O O . LYS B 1 72 ? -7.214 0.079 33.785 1.00 32.82 ? 72 LYS B O 1 ATOM 4882 C CB . LYS B 1 72 ? -5.892 2.476 35.429 1.00 23.83 ? 72 LYS B CB 1 ATOM 4883 C CG . LYS B 1 72 ? -4.479 2.801 35.848 1.00 22.08 ? 72 LYS B CG 1 ATOM 4884 C CD . LYS B 1 72 ? -4.279 2.524 37.332 1.00 29.04 ? 72 LYS B CD 1 ATOM 4885 C CE . LYS B 1 72 ? -3.479 3.630 37.993 1.00 46.89 ? 72 LYS B CE 1 ATOM 4886 N NZ . LYS B 1 72 ? -2.640 3.156 39.128 1.00 52.62 ? 72 LYS B NZ 1 ATOM 4887 N N . ALA B 1 73 ? -8.499 1.926 33.454 1.00 30.35 ? 73 ALA B N 1 ATOM 4888 C CA . ALA B 1 73 ? -9.747 1.200 33.174 1.00 31.21 ? 73 ALA B CA 1 ATOM 4889 C C . ALA B 1 73 ? -9.679 0.519 31.805 1.00 37.36 ? 73 ALA B C 1 ATOM 4890 O O . ALA B 1 73 ? -10.159 -0.608 31.665 1.00 37.87 ? 73 ALA B O 1 ATOM 4891 C CB . ALA B 1 73 ? -10.952 2.135 33.247 1.00 31.95 ? 73 ALA B CB 1 ATOM 4892 N N . LYS B 1 74 ? -9.075 1.193 30.806 1.00 34.80 ? 74 LYS B N 1 ATOM 4893 C CA . LYS B 1 74 ? -8.900 0.640 29.464 1.00 35.30 ? 74 LYS B CA 1 ATOM 4894 C C . LYS B 1 74 ? -7.783 -0.423 29.478 1.00 40.53 ? 74 LYS B C 1 ATOM 4895 O O . LYS B 1 74 ? -7.950 -1.490 28.885 1.00 40.11 ? 74 LYS B O 1 ATOM 4896 C CB . LYS B 1 74 ? -8.611 1.742 28.435 1.00 38.10 ? 74 LYS B CB 1 ATOM 4897 C CG . LYS B 1 74 ? -9.709 2.786 28.336 1.00 50.24 ? 74 LYS B CG 1 ATOM 4898 C CD . LYS B 1 74 ? -9.528 3.673 27.116 1.00 61.63 ? 74 LYS B CD 1 ATOM 4899 C CE . LYS B 1 74 ? -9.874 5.121 27.394 1.00 72.21 ? 74 LYS B CE 1 ATOM 4900 N NZ . LYS B 1 74 ? -8.719 5.879 27.951 1.00 75.71 ? 74 LYS B NZ 1 ATOM 4901 N N . ALA B 1 75 ? -6.681 -0.154 30.216 1.00 37.96 ? 75 ALA B N 1 ATOM 4902 C CA . ALA B 1 75 ? -5.531 -1.054 30.390 1.00 38.11 ? 75 ALA B CA 1 ATOM 4903 C C . ALA B 1 75 ? -5.928 -2.397 30.997 1.00 42.59 ? 75 ALA B C 1 ATOM 4904 O O . ALA B 1 75 ? -5.304 -3.400 30.684 1.00 43.69 ? 75 ALA B O 1 ATOM 4905 C CB . ALA B 1 75 ? -4.475 -0.390 31.270 1.00 39.01 ? 75 ALA B CB 1 ATOM 4906 N N . SER B 1 76 ? -6.959 -2.422 31.854 1.00 38.51 ? 76 SER B N 1 ATOM 4907 C CA . SER B 1 76 ? -7.423 -3.641 32.503 1.00 37.82 ? 76 SER B CA 1 ATOM 4908 C C . SER B 1 76 ? -8.169 -4.586 31.549 1.00 42.03 ? 76 SER B C 1 ATOM 4909 O O . SER B 1 76 ? -8.403 -5.736 31.921 1.00 43.71 ? 76 SER B O 1 ATOM 4910 C CB . SER B 1 76 ? -8.242 -3.323 33.753 1.00 40.13 ? 76 SER B CB 1 ATOM 4911 O OG . SER B 1 76 ? -9.472 -2.692 33.449 1.00 45.99 ? 76 SER B OG 1 ATOM 4912 N N . THR B 1 77 ? -8.495 -4.129 30.315 1.00 36.56 ? 77 THR B N 1 ATOM 4913 C CA . THR B 1 77 ? -9.148 -4.956 29.281 1.00 35.92 ? 77 THR B CA 1 ATOM 4914 C C . THR B 1 77 ? -8.101 -5.615 28.348 1.00 38.34 ? 77 THR B C 1 ATOM 4915 O O . THR B 1 77 ? -8.468 -6.399 27.463 1.00 35.97 ? 77 THR B O 1 ATOM 4916 C CB . THR B 1 77 ? -10.176 -4.163 28.456 1.00 41.10 ? 77 THR B CB 1 ATOM 4917 O OG1 . THR B 1 77 ? -9.513 -3.433 27.410 1.00 35.25 ? 77 THR B OG1 1 ATOM 4918 C CG2 . THR B 1 77 ? -11.076 -3.274 29.318 1.00 40.05 ? 77 THR B CG2 1 ATOM 4919 N N . VAL B 1 78 ? -6.810 -5.278 28.550 1.00 34.26 ? 78 VAL B N 1 ATOM 4920 C CA . VAL B 1 78 ? -5.698 -5.822 27.776 1.00 33.65 ? 78 VAL B CA 1 ATOM 4921 C C . VAL B 1 78 ? -5.272 -7.165 28.382 1.00 38.11 ? 78 VAL B C 1 ATOM 4922 O O . VAL B 1 78 ? -5.187 -7.282 29.606 1.00 37.40 ? 78 VAL B O 1 ATOM 4923 C CB . VAL B 1 78 ? -4.482 -4.839 27.706 1.00 36.53 ? 78 VAL B CB 1 ATOM 4924 C CG1 . VAL B 1 78 ? -3.398 -5.339 26.750 1.00 36.21 ? 78 VAL B CG1 1 ATOM 4925 C CG2 . VAL B 1 78 ? -4.906 -3.432 27.331 1.00 36.11 ? 78 VAL B CG2 1 ATOM 4926 N N . LYS B 1 79 ? -4.983 -8.161 27.520 1.00 35.24 ? 79 LYS B N 1 ATOM 4927 C CA . LYS B 1 79 ? -4.418 -9.454 27.928 1.00 35.64 ? 79 LYS B CA 1 ATOM 4928 C C . LYS B 1 79 ? -3.067 -9.550 27.221 1.00 39.51 ? 79 LYS B C 1 ATOM 4929 O O . LYS B 1 79 ? -2.992 -9.304 26.016 1.00 39.51 ? 79 LYS B O 1 ATOM 4930 C CB . LYS B 1 79 ? -5.310 -10.638 27.525 1.00 38.23 ? 79 LYS B CB 1 ATOM 4931 C CG . LYS B 1 79 ? -4.871 -11.942 28.158 1.00 49.10 ? 79 LYS B CG 1 ATOM 4932 C CD . LYS B 1 79 ? -5.534 -13.144 27.528 1.00 54.68 ? 79 LYS B CD 1 ATOM 4933 C CE . LYS B 1 79 ? -5.422 -14.363 28.407 1.00 59.90 ? 79 LYS B CE 1 ATOM 4934 N NZ . LYS B 1 79 ? -6.306 -14.270 29.594 1.00 70.85 ? 79 LYS B NZ 1 ATOM 4935 N N . ALA B 1 80 ? -2.003 -9.865 27.959 1.00 35.00 ? 80 ALA B N 1 ATOM 4936 C CA . ALA B 1 80 ? -0.681 -9.944 27.346 1.00 34.50 ? 80 ALA B CA 1 ATOM 4937 C C . ALA B 1 80 ? 0.004 -11.291 27.571 1.00 40.43 ? 80 ALA B C 1 ATOM 4938 O O . ALA B 1 80 ? -0.090 -11.870 28.661 1.00 39.22 ? 80 ALA B O 1 ATOM 4939 C CB . ALA B 1 80 ? 0.193 -8.806 27.828 1.00 34.81 ? 80 ALA B CB 1 ATOM 4940 N N . LYS B 1 81 ? 0.691 -11.783 26.526 1.00 39.17 ? 81 LYS B N 1 ATOM 4941 C CA . LYS B 1 81 ? 1.380 -13.062 26.570 1.00 40.08 ? 81 LYS B CA 1 ATOM 4942 C C . LYS B 1 81 ? 2.853 -12.910 26.868 1.00 46.45 ? 81 LYS B C 1 ATOM 4943 O O . LYS B 1 81 ? 3.503 -11.968 26.402 1.00 45.78 ? 81 LYS B O 1 ATOM 4944 C CB . LYS B 1 81 ? 1.135 -13.918 25.292 1.00 42.70 ? 81 LYS B CB 1 ATOM 4945 C CG . LYS B 1 81 ? 1.871 -13.470 24.026 1.00 58.00 ? 81 LYS B CG 1 ATOM 4946 C CD . LYS B 1 81 ? 1.606 -14.378 22.828 1.00 72.22 ? 81 LYS B CD 1 ATOM 4947 C CE . LYS B 1 81 ? 2.270 -13.850 21.568 1.00 86.13 ? 81 LYS B CE 1 ATOM 4948 N NZ . LYS B 1 81 ? 1.974 -14.693 20.374 1.00 93.33 ? 81 LYS B NZ 1 ATOM 4949 N N . LEU B 1 82 ? 3.375 -13.864 27.646 1.00 45.23 ? 82 LEU B N 1 ATOM 4950 C CA . LEU B 1 82 ? 4.785 -13.939 27.985 1.00 45.74 ? 82 LEU B CA 1 ATOM 4951 C C . LEU B 1 82 ? 5.460 -14.599 26.784 1.00 51.39 ? 82 LEU B C 1 ATOM 4952 O O . LEU B 1 82 ? 5.010 -15.643 26.300 1.00 51.96 ? 82 LEU B O 1 ATOM 4953 C CB . LEU B 1 82 ? 4.976 -14.780 29.252 1.00 45.87 ? 82 LEU B CB 1 ATOM 4954 C CG . LEU B 1 82 ? 6.310 -14.624 29.951 1.00 51.50 ? 82 LEU B CG 1 ATOM 4955 C CD1 . LEU B 1 82 ? 6.115 -14.280 31.396 1.00 51.68 ? 82 LEU B CD1 1 ATOM 4956 C CD2 . LEU B 1 82 ? 7.142 -15.897 29.827 1.00 55.29 ? 82 LEU B CD2 1 ATOM 4957 N N . LEU B 1 83 ? 6.482 -13.956 26.252 1.00 47.96 ? 83 LEU B N 1 ATOM 4958 C CA . LEU B 1 83 ? 7.197 -14.524 25.122 1.00 47.81 ? 83 LEU B CA 1 ATOM 4959 C C . LEU B 1 83 ? 8.193 -15.576 25.617 1.00 52.51 ? 83 LEU B C 1 ATOM 4960 O O . LEU B 1 83 ? 8.641 -15.513 26.764 1.00 52.13 ? 83 LEU B O 1 ATOM 4961 C CB . LEU B 1 83 ? 7.916 -13.405 24.368 1.00 47.80 ? 83 LEU B CB 1 ATOM 4962 C CG . LEU B 1 83 ? 7.308 -12.944 23.045 1.00 52.12 ? 83 LEU B CG 1 ATOM 4963 C CD1 . LEU B 1 83 ? 5.886 -12.352 23.221 1.00 52.02 ? 83 LEU B CD1 1 ATOM 4964 C CD2 . LEU B 1 83 ? 8.216 -11.938 22.397 1.00 54.00 ? 83 LEU B CD2 1 ATOM 4965 N N . SER B 1 84 ? 8.501 -16.568 24.774 1.00 49.66 ? 84 SER B N 1 ATOM 4966 C CA . SER B 1 84 ? 9.466 -17.610 25.125 1.00 49.31 ? 84 SER B CA 1 ATOM 4967 C C . SER B 1 84 ? 10.860 -17.088 24.805 1.00 51.18 ? 84 SER B C 1 ATOM 4968 O O . SER B 1 84 ? 10.988 -16.143 24.018 1.00 49.84 ? 84 SER B O 1 ATOM 4969 C CB . SER B 1 84 ? 9.182 -18.901 24.358 1.00 54.06 ? 84 SER B CB 1 ATOM 4970 O OG . SER B 1 84 ? 9.313 -18.757 22.951 1.00 64.24 ? 84 SER B OG 1 ATOM 4971 N N . VAL B 1 85 ? 11.906 -17.697 25.414 1.00 46.57 ? 85 VAL B N 1 ATOM 4972 C CA . VAL B 1 85 ? 13.305 -17.315 25.188 1.00 44.89 ? 85 VAL B CA 1 ATOM 4973 C C . VAL B 1 85 ? 13.531 -17.245 23.681 1.00 46.87 ? 85 VAL B C 1 ATOM 4974 O O . VAL B 1 85 ? 13.958 -16.207 23.192 1.00 46.68 ? 85 VAL B O 1 ATOM 4975 C CB . VAL B 1 85 ? 14.323 -18.242 25.911 1.00 47.77 ? 85 VAL B CB 1 ATOM 4976 C CG1 . VAL B 1 85 ? 15.761 -17.846 25.577 1.00 47.51 ? 85 VAL B CG1 1 ATOM 4977 C CG2 . VAL B 1 85 ? 14.111 -18.231 27.425 1.00 47.13 ? 85 VAL B CG2 1 ATOM 4978 N N . GLU B 1 86 ? 13.129 -18.305 22.952 1.00 42.55 ? 86 GLU B N 1 ATOM 4979 C CA . GLU B 1 86 ? 13.193 -18.426 21.494 1.00 42.15 ? 86 GLU B CA 1 ATOM 4980 C C . GLU B 1 86 ? 12.487 -17.249 20.802 1.00 44.21 ? 86 GLU B C 1 ATOM 4981 O O . GLU B 1 86 ? 13.098 -16.609 19.944 1.00 43.50 ? 86 GLU B O 1 ATOM 4982 C CB . GLU B 1 86 ? 12.583 -19.768 21.043 1.00 44.02 ? 86 GLU B CB 1 ATOM 4983 C CG . GLU B 1 86 ? 12.630 -19.992 19.538 1.00 62.85 ? 86 GLU B CG 1 ATOM 4984 C CD . GLU B 1 86 ? 12.307 -21.375 18.990 1.00 89.99 ? 86 GLU B CD 1 ATOM 4985 O OE1 . GLU B 1 86 ? 11.576 -22.144 19.656 1.00 95.70 ? 86 GLU B OE1 1 ATOM 4986 O OE2 . GLU B 1 86 ? 12.746 -21.660 17.853 1.00 77.12 ? 86 GLU B OE2 1 ATOM 4987 N N . GLU B 1 87 ? 11.213 -16.966 21.182 1.00 39.26 ? 87 GLU B N 1 ATOM 4988 C CA . GLU B 1 87 ? 10.421 -15.876 20.606 1.00 38.58 ? 87 GLU B CA 1 ATOM 4989 C C . GLU B 1 87 ? 11.105 -14.534 20.807 1.00 43.71 ? 87 GLU B C 1 ATOM 4990 O O . GLU B 1 87 ? 11.222 -13.765 19.856 1.00 44.43 ? 87 GLU B O 1 ATOM 4991 C CB . GLU B 1 87 ? 9.006 -15.844 21.188 1.00 39.75 ? 87 GLU B CB 1 ATOM 4992 C CG . GLU B 1 87 ? 8.031 -16.802 20.529 1.00 48.40 ? 87 GLU B CG 1 ATOM 4993 C CD . GLU B 1 87 ? 6.691 -16.869 21.237 1.00 69.04 ? 87 GLU B CD 1 ATOM 4994 O OE1 . GLU B 1 87 ? 6.672 -17.212 22.443 1.00 69.01 ? 87 GLU B OE1 1 ATOM 4995 O OE2 . GLU B 1 87 ? 5.662 -16.564 20.591 1.00 55.06 ? 87 GLU B OE2 1 ATOM 4996 N N . ALA B 1 88 ? 11.603 -14.276 22.032 1.00 40.41 ? 88 ALA B N 1 ATOM 4997 C CA . ALA B 1 88 ? 12.319 -13.055 22.391 1.00 39.50 ? 88 ALA B CA 1 ATOM 4998 C C . ALA B 1 88 ? 13.654 -12.933 21.634 1.00 43.67 ? 88 ALA B C 1 ATOM 4999 O O . ALA B 1 88 ? 13.974 -11.846 21.162 1.00 42.59 ? 88 ALA B O 1 ATOM 5000 C CB . ALA B 1 88 ? 12.539 -13.009 23.886 1.00 39.69 ? 88 ALA B CB 1 ATOM 5001 N N . CYS B 1 89 ? 14.394 -14.058 21.473 1.00 41.77 ? 89 CYS B N 1 ATOM 5002 C CA . CYS B 1 89 ? 15.674 -14.160 20.754 1.00 42.52 ? 89 CYS B CA 1 ATOM 5003 C C . CYS B 1 89 ? 15.529 -13.803 19.260 1.00 46.59 ? 89 CYS B C 1 ATOM 5004 O O . CYS B 1 89 ? 16.458 -13.267 18.660 1.00 45.71 ? 89 CYS B O 1 ATOM 5005 C CB . CYS B 1 89 ? 16.271 -15.557 20.913 1.00 43.20 ? 89 CYS B CB 1 ATOM 5006 S SG . CYS B 1 89 ? 17.144 -15.847 22.475 1.00 47.41 ? 89 CYS B SG 1 ATOM 5007 N N . LYS B 1 90 ? 14.389 -14.165 18.659 1.00 43.60 ? 90 LYS B N 1 ATOM 5008 C CA . LYS B 1 90 ? 14.104 -13.928 17.243 1.00 43.58 ? 90 LYS B CA 1 ATOM 5009 C C . LYS B 1 90 ? 13.740 -12.466 16.938 1.00 48.40 ? 90 LYS B C 1 ATOM 5010 O O . LYS B 1 90 ? 13.849 -12.031 15.793 1.00 47.48 ? 90 LYS B O 1 ATOM 5011 C CB . LYS B 1 90 ? 13.031 -14.910 16.731 1.00 45.55 ? 90 LYS B CB 1 ATOM 5012 C CG . LYS B 1 90 ? 13.480 -16.378 16.743 1.00 54.98 ? 90 LYS B CG 1 ATOM 5013 C CD . LYS B 1 90 ? 14.642 -16.648 15.794 1.00 63.37 ? 90 LYS B CD 1 ATOM 5014 C CE . LYS B 1 90 ? 15.159 -18.056 15.901 1.00 74.56 ? 90 LYS B CE 1 ATOM 5015 N NZ . LYS B 1 90 ? 16.193 -18.324 14.866 1.00 83.80 ? 90 LYS B NZ 1 ATOM 5016 N N . LEU B 1 91 ? 13.339 -11.706 17.958 1.00 45.72 ? 91 LEU B N 1 ATOM 5017 C CA . LEU B 1 91 ? 13.003 -10.296 17.809 1.00 45.68 ? 91 LEU B CA 1 ATOM 5018 C C . LEU B 1 91 ? 14.232 -9.396 18.045 1.00 49.50 ? 91 LEU B C 1 ATOM 5019 O O . LEU B 1 91 ? 14.111 -8.170 18.005 1.00 49.85 ? 91 LEU B O 1 ATOM 5020 C CB . LEU B 1 91 ? 11.858 -9.920 18.770 1.00 45.70 ? 91 LEU B CB 1 ATOM 5021 C CG . LEU B 1 91 ? 10.441 -10.280 18.351 1.00 49.91 ? 91 LEU B CG 1 ATOM 5022 C CD1 . LEU B 1 91 ? 9.555 -10.327 19.547 1.00 50.07 ? 91 LEU B CD1 1 ATOM 5023 C CD2 . LEU B 1 91 ? 9.879 -9.276 17.347 1.00 50.60 ? 91 LEU B CD2 1 ATOM 5024 N N . THR B 1 92 ? 15.405 -9.995 18.266 1.00 45.28 ? 92 THR B N 1 ATOM 5025 C CA . THR B 1 92 ? 16.641 -9.254 18.527 1.00 45.41 ? 92 THR B CA 1 ATOM 5026 C C . THR B 1 92 ? 17.308 -8.755 17.234 1.00 49.70 ? 92 THR B C 1 ATOM 5027 O O . THR B 1 92 ? 17.643 -9.583 16.383 1.00 48.47 ? 92 THR B O 1 ATOM 5028 C CB . THR B 1 92 ? 17.604 -10.098 19.410 1.00 48.98 ? 92 THR B CB 1 ATOM 5029 O OG1 . THR B 1 92 ? 16.902 -10.558 20.570 1.00 49.15 ? 92 THR B OG1 1 ATOM 5030 C CG2 . THR B 1 92 ? 18.859 -9.327 19.839 1.00 42.64 ? 92 THR B CG2 1 ATOM 5031 N N . PRO B 1 93 ? 17.581 -7.424 17.100 1.00 47.92 ? 93 PRO B N 1 ATOM 5032 C CA . PRO B 1 93 ? 18.291 -6.921 15.894 1.00 48.09 ? 93 PRO B CA 1 ATOM 5033 C C . PRO B 1 93 ? 19.601 -7.676 15.611 1.00 53.02 ? 93 PRO B C 1 ATOM 5034 O O . PRO B 1 93 ? 20.246 -8.105 16.561 1.00 52.00 ? 93 PRO B O 1 ATOM 5035 C CB . PRO B 1 93 ? 18.533 -5.445 16.210 1.00 49.52 ? 93 PRO B CB 1 ATOM 5036 C CG . PRO B 1 93 ? 17.463 -5.098 17.180 1.00 54.06 ? 93 PRO B CG 1 ATOM 5037 C CD . PRO B 1 93 ? 17.258 -6.319 18.025 1.00 49.49 ? 93 PRO B CD 1 ATOM 5038 N N . PRO B 1 94 ? 19.976 -7.934 14.334 1.00 50.97 ? 94 PRO B N 1 ATOM 5039 C CA . PRO B 1 94 ? 21.198 -8.724 14.082 1.00 49.97 ? 94 PRO B CA 1 ATOM 5040 C C . PRO B 1 94 ? 22.489 -8.010 14.458 1.00 53.59 ? 94 PRO B C 1 ATOM 5041 O O . PRO B 1 94 ? 23.472 -8.672 14.791 1.00 53.74 ? 94 PRO B O 1 ATOM 5042 C CB . PRO B 1 94 ? 21.133 -9.048 12.581 1.00 51.65 ? 94 PRO B CB 1 ATOM 5043 C CG . PRO B 1 94 ? 19.831 -8.513 12.082 1.00 56.75 ? 94 PRO B CG 1 ATOM 5044 C CD . PRO B 1 94 ? 19.327 -7.512 13.071 1.00 52.95 ? 94 PRO B CD 1 ATOM 5045 N N . HIS B 1 95 ? 22.485 -6.669 14.408 1.00 49.67 ? 95 HIS B N 1 ATOM 5046 C CA . HIS B 1 95 ? 23.653 -5.853 14.724 1.00 49.50 ? 95 HIS B CA 1 ATOM 5047 C C . HIS B 1 95 ? 23.447 -5.088 16.053 1.00 50.31 ? 95 HIS B C 1 ATOM 5048 O O . HIS B 1 95 ? 23.941 -3.968 16.241 1.00 49.96 ? 95 HIS B O 1 ATOM 5049 C CB . HIS B 1 95 ? 24.027 -4.964 13.518 1.00 51.35 ? 95 HIS B CB 1 ATOM 5050 C CG . HIS B 1 95 ? 24.363 -5.771 12.286 1.00 55.72 ? 95 HIS B CG 1 ATOM 5051 N ND1 . HIS B 1 95 ? 23.409 -6.043 11.315 1.00 57.48 ? 95 HIS B ND1 1 ATOM 5052 C CD2 . HIS B 1 95 ? 25.517 -6.400 11.947 1.00 58.18 ? 95 HIS B CD2 1 ATOM 5053 C CE1 . HIS B 1 95 ? 24.017 -6.802 10.414 1.00 57.23 ? 95 HIS B CE1 1 ATOM 5054 N NE2 . HIS B 1 95 ? 25.285 -7.045 10.749 1.00 57.82 ? 95 HIS B NE2 1 ATOM 5055 N N . SER B 1 96 ? 22.738 -5.752 16.994 1.00 43.66 ? 96 SER B N 1 ATOM 5056 C CA . SER B 1 96 ? 22.444 -5.260 18.331 1.00 42.00 ? 96 SER B CA 1 ATOM 5057 C C . SER B 1 96 ? 23.709 -5.416 19.168 1.00 43.55 ? 96 SER B C 1 ATOM 5058 O O . SER B 1 96 ? 24.494 -6.320 18.896 1.00 43.52 ? 96 SER B O 1 ATOM 5059 C CB . SER B 1 96 ? 21.288 -6.056 18.928 1.00 44.67 ? 96 SER B CB 1 ATOM 5060 O OG . SER B 1 96 ? 21.064 -5.775 20.298 1.00 52.05 ? 96 SER B OG 1 ATOM 5061 N N . ALA B 1 97 ? 23.914 -4.530 20.167 1.00 38.22 ? 97 ALA B N 1 ATOM 5062 C CA . ALA B 1 97 ? 25.074 -4.516 21.066 1.00 37.12 ? 97 ALA B CA 1 ATOM 5063 C C . ALA B 1 97 ? 25.309 -5.869 21.750 1.00 42.69 ? 97 ALA B C 1 ATOM 5064 O O . ALA B 1 97 ? 24.387 -6.443 22.338 1.00 42.13 ? 97 ALA B O 1 ATOM 5065 C CB . ALA B 1 97 ? 24.924 -3.410 22.107 1.00 37.29 ? 97 ALA B CB 1 ATOM 5066 N N . LYS B 1 98 ? 26.542 -6.390 21.627 1.00 41.27 ? 98 LYS B N 1 ATOM 5067 C CA . LYS B 1 98 ? 26.978 -7.663 22.222 1.00 42.28 ? 98 LYS B CA 1 ATOM 5068 C C . LYS B 1 98 ? 26.922 -7.628 23.756 1.00 47.29 ? 98 LYS B C 1 ATOM 5069 O O . LYS B 1 98 ? 27.141 -6.585 24.361 1.00 46.91 ? 98 LYS B O 1 ATOM 5070 C CB . LYS B 1 98 ? 28.400 -8.063 21.736 1.00 45.27 ? 98 LYS B CB 1 ATOM 5071 C CG . LYS B 1 98 ? 29.522 -7.131 22.214 1.00 59.72 ? 98 LYS B CG 1 ATOM 5072 C CD . LYS B 1 98 ? 30.830 -7.326 21.463 1.00 71.40 ? 98 LYS B CD 1 ATOM 5073 C CE . LYS B 1 98 ? 31.790 -6.163 21.653 1.00 82.04 ? 98 LYS B CE 1 ATOM 5074 N NZ . LYS B 1 98 ? 32.354 -6.086 23.035 1.00 88.08 ? 98 LYS B NZ 1 ATOM 5075 N N . SER B 1 99 ? 26.630 -8.772 24.368 1.00 44.95 ? 99 SER B N 1 ATOM 5076 C CA . SER B 1 99 ? 26.579 -8.933 25.817 1.00 44.62 ? 99 SER B CA 1 ATOM 5077 C C . SER B 1 99 ? 28.006 -8.927 26.416 1.00 50.25 ? 99 SER B C 1 ATOM 5078 O O . SER B 1 99 ? 28.957 -9.406 25.785 1.00 51.17 ? 99 SER B O 1 ATOM 5079 C CB . SER B 1 99 ? 25.862 -10.232 26.168 1.00 45.35 ? 99 SER B CB 1 ATOM 5080 O OG . SER B 1 99 ? 25.969 -10.564 27.540 1.00 46.38 ? 99 SER B OG 1 ATOM 5081 N N . LYS B 1 100 ? 28.137 -8.400 27.645 1.00 46.33 ? 100 LYS B N 1 ATOM 5082 C CA . LYS B 1 100 ? 29.387 -8.346 28.408 1.00 46.24 ? 100 LYS B CA 1 ATOM 5083 C C . LYS B 1 100 ? 29.785 -9.757 28.845 1.00 52.67 ? 100 LYS B C 1 ATOM 5084 O O . LYS B 1 100 ? 30.910 -9.970 29.284 1.00 52.66 ? 100 LYS B O 1 ATOM 5085 C CB . LYS B 1 100 ? 29.212 -7.456 29.661 1.00 48.05 ? 100 LYS B CB 1 ATOM 5086 C CG . LYS B 1 100 ? 29.168 -5.951 29.377 1.00 60.16 ? 100 LYS B CG 1 ATOM 5087 C CD . LYS B 1 100 ? 28.955 -5.095 30.643 1.00 65.23 ? 100 LYS B CD 1 ATOM 5088 C CE . LYS B 1 100 ? 29.155 -3.609 30.390 1.00 59.94 ? 100 LYS B CE 1 ATOM 5089 N NZ . LYS B 1 100 ? 28.624 -2.759 31.492 1.00 54.70 ? 100 LYS B NZ 1 ATOM 5090 N N . PHE B 1 101 ? 28.851 -10.717 28.719 1.00 51.19 ? 101 PHE B N 1 ATOM 5091 C CA . PHE B 1 101 ? 28.955 -12.119 29.136 1.00 50.87 ? 101 PHE B CA 1 ATOM 5092 C C . PHE B 1 101 ? 29.359 -13.060 27.994 1.00 55.90 ? 101 PHE B C 1 ATOM 5093 O O . PHE B 1 101 ? 29.006 -14.243 27.990 1.00 56.47 ? 101 PHE B O 1 ATOM 5094 C CB . PHE B 1 101 ? 27.653 -12.549 29.832 1.00 52.26 ? 101 PHE B CB 1 ATOM 5095 C CG . PHE B 1 101 ? 27.418 -11.754 31.099 1.00 54.02 ? 101 PHE B CG 1 ATOM 5096 C CD1 . PHE B 1 101 ? 26.796 -10.510 31.055 1.00 56.55 ? 101 PHE B CD1 1 ATOM 5097 C CD2 . PHE B 1 101 ? 27.841 -12.239 32.335 1.00 56.71 ? 101 PHE B CD2 1 ATOM 5098 C CE1 . PHE B 1 101 ? 26.601 -9.767 32.220 1.00 57.86 ? 101 PHE B CE1 1 ATOM 5099 C CE2 . PHE B 1 101 ? 27.633 -11.498 33.504 1.00 59.24 ? 101 PHE B CE2 1 ATOM 5100 C CZ . PHE B 1 101 ? 27.025 -10.262 33.436 1.00 57.23 ? 101 PHE B CZ 1 ATOM 5101 N N . GLY B 1 102 ? 30.148 -12.504 27.077 1.00 52.16 ? 102 GLY B N 1 ATOM 5102 C CA . GLY B 1 102 ? 30.758 -13.192 25.950 1.00 52.14 ? 102 GLY B CA 1 ATOM 5103 C C . GLY B 1 102 ? 29.849 -13.838 24.936 1.00 56.70 ? 102 GLY B C 1 ATOM 5104 O O . GLY B 1 102 ? 29.951 -15.044 24.707 1.00 56.28 ? 102 GLY B O 1 ATOM 5105 N N . TYR B 1 103 ? 29.001 -13.032 24.281 1.00 53.81 ? 103 TYR B N 1 ATOM 5106 C CA . TYR B 1 103 ? 28.100 -13.442 23.191 1.00 53.57 ? 103 TYR B CA 1 ATOM 5107 C C . TYR B 1 103 ? 27.434 -12.206 22.613 1.00 57.77 ? 103 TYR B C 1 ATOM 5108 O O . TYR B 1 103 ? 27.502 -11.143 23.232 1.00 56.53 ? 103 TYR B O 1 ATOM 5109 C CB . TYR B 1 103 ? 27.088 -14.561 23.585 1.00 54.30 ? 103 TYR B CB 1 ATOM 5110 C CG . TYR B 1 103 ? 25.978 -14.129 24.512 1.00 55.21 ? 103 TYR B CG 1 ATOM 5111 C CD1 . TYR B 1 103 ? 24.814 -13.547 24.016 1.00 57.19 ? 103 TYR B CD1 1 ATOM 5112 C CD2 . TYR B 1 103 ? 26.071 -14.333 25.885 1.00 55.65 ? 103 TYR B CD2 1 ATOM 5113 C CE1 . TYR B 1 103 ? 23.788 -13.140 24.866 1.00 57.67 ? 103 TYR B CE1 1 ATOM 5114 C CE2 . TYR B 1 103 ? 25.052 -13.925 26.746 1.00 56.55 ? 103 TYR B CE2 1 ATOM 5115 C CZ . TYR B 1 103 ? 23.909 -13.333 26.228 1.00 62.09 ? 103 TYR B CZ 1 ATOM 5116 O OH . TYR B 1 103 ? 22.892 -12.913 27.043 1.00 60.07 ? 103 TYR B OH 1 ATOM 5117 N N . GLY B 1 104 ? 26.818 -12.351 21.438 1.00 55.54 ? 104 GLY B N 1 ATOM 5118 C CA . GLY B 1 104 ? 26.168 -11.250 20.733 1.00 55.13 ? 104 GLY B CA 1 ATOM 5119 C C . GLY B 1 104 ? 24.799 -11.556 20.170 1.00 57.13 ? 104 GLY B C 1 ATOM 5120 O O . GLY B 1 104 ? 24.223 -12.618 20.441 1.00 55.16 ? 104 GLY B O 1 ATOM 5121 N N . ALA B 1 105 ? 24.267 -10.584 19.400 1.00 53.81 ? 105 ALA B N 1 ATOM 5122 C CA . ALA B 1 105 ? 22.957 -10.629 18.740 1.00 53.53 ? 105 ALA B CA 1 ATOM 5123 C C . ALA B 1 105 ? 22.802 -11.830 17.820 1.00 57.73 ? 105 ALA B C 1 ATOM 5124 O O . ALA B 1 105 ? 21.741 -12.439 17.829 1.00 57.49 ? 105 ALA B O 1 ATOM 5125 C CB . ALA B 1 105 ? 22.711 -9.346 17.976 1.00 54.11 ? 105 ALA B CB 1 ATOM 5126 N N . LYS B 1 106 ? 23.872 -12.202 17.075 1.00 54.70 ? 106 LYS B N 1 ATOM 5127 C CA . LYS B 1 106 ? 23.913 -13.371 16.186 1.00 54.40 ? 106 LYS B CA 1 ATOM 5128 C C . LYS B 1 106 ? 23.779 -14.658 17.018 1.00 57.59 ? 106 LYS B C 1 ATOM 5129 O O . LYS B 1 106 ? 22.918 -15.488 16.715 1.00 56.61 ? 106 LYS B O 1 ATOM 5130 C CB . LYS B 1 106 ? 25.203 -13.377 15.338 1.00 57.20 ? 106 LYS B CB 1 ATOM 5131 C CG . LYS B 1 106 ? 25.280 -12.249 14.290 1.00 68.04 ? 106 LYS B CG 1 ATOM 5132 C CD . LYS B 1 106 ? 24.672 -12.631 12.933 1.00 71.83 ? 106 LYS B CD 1 ATOM 5133 C CE . LYS B 1 106 ? 24.987 -11.627 11.847 1.00 72.18 ? 106 LYS B CE 1 ATOM 5134 N NZ . LYS B 1 106 ? 24.483 -12.070 10.515 1.00 73.09 ? 106 LYS B NZ 1 ATOM 5135 N N . ASP B 1 107 ? 24.573 -14.772 18.114 1.00 54.31 ? 107 ASP B N 1 ATOM 5136 C CA . ASP B 1 107 ? 24.546 -15.875 19.090 1.00 53.99 ? 107 ASP B CA 1 ATOM 5137 C C . ASP B 1 107 ? 23.135 -16.016 19.693 1.00 57.35 ? 107 ASP B C 1 ATOM 5138 O O . ASP B 1 107 ? 22.656 -17.132 19.855 1.00 57.82 ? 107 ASP B O 1 ATOM 5139 C CB . ASP B 1 107 ? 25.587 -15.653 20.212 1.00 56.13 ? 107 ASP B CB 1 ATOM 5140 C CG . ASP B 1 107 ? 27.049 -15.521 19.779 1.00 70.45 ? 107 ASP B CG 1 ATOM 5141 O OD1 . ASP B 1 107 ? 27.313 -14.866 18.742 1.00 71.51 ? 107 ASP B OD1 1 ATOM 5142 O OD2 . ASP B 1 107 ? 27.935 -15.976 20.535 1.00 78.08 ? 107 ASP B OD2 1 ATOM 5143 N N . VAL B 1 108 ? 22.456 -14.880 19.972 1.00 52.66 ? 108 VAL B N 1 ATOM 5144 C CA . VAL B 1 108 ? 21.075 -14.804 20.487 1.00 50.87 ? 108 VAL B CA 1 ATOM 5145 C C . VAL B 1 108 ? 20.099 -15.345 19.421 1.00 53.74 ? 108 VAL B C 1 ATOM 5146 O O . VAL B 1 108 ? 19.422 -16.338 19.673 1.00 53.29 ? 108 VAL B O 1 ATOM 5147 C CB . VAL B 1 108 ? 20.725 -13.359 20.977 1.00 52.82 ? 108 VAL B CB 1 ATOM 5148 C CG1 . VAL B 1 108 ? 19.224 -13.132 21.083 1.00 52.32 ? 108 VAL B CG1 1 ATOM 5149 C CG2 . VAL B 1 108 ? 21.388 -13.067 22.304 1.00 52.05 ? 108 VAL B CG2 1 ATOM 5150 N N . ARG B 1 109 ? 20.079 -14.721 18.223 1.00 49.69 ? 109 ARG B N 1 ATOM 5151 C CA . ARG B 1 109 ? 19.228 -15.082 17.083 1.00 49.23 ? 109 ARG B CA 1 ATOM 5152 C C . ARG B 1 109 ? 19.318 -16.581 16.701 1.00 54.74 ? 109 ARG B C 1 ATOM 5153 O O . ARG B 1 109 ? 18.322 -17.148 16.254 1.00 55.13 ? 109 ARG B O 1 ATOM 5154 C CB . ARG B 1 109 ? 19.556 -14.198 15.868 1.00 46.51 ? 109 ARG B CB 1 ATOM 5155 C CG . ARG B 1 109 ? 19.145 -12.730 16.015 1.00 48.55 ? 109 ARG B CG 1 ATOM 5156 C CD . ARG B 1 109 ? 19.057 -12.018 14.674 1.00 51.56 ? 109 ARG B CD 1 ATOM 5157 N NE . ARG B 1 109 ? 18.025 -12.600 13.810 1.00 58.24 ? 109 ARG B NE 1 ATOM 5158 C CZ . ARG B 1 109 ? 16.735 -12.281 13.851 1.00 77.22 ? 109 ARG B CZ 1 ATOM 5159 N NH1 . ARG B 1 109 ? 16.296 -11.370 14.711 1.00 71.95 ? 109 ARG B NH1 1 ATOM 5160 N NH2 . ARG B 1 109 ? 15.874 -12.869 13.031 1.00 63.86 ? 109 ARG B NH2 1 ATOM 5161 N N . ASN B 1 110 ? 20.506 -17.212 16.883 1.00 50.57 ? 110 ASN B N 1 ATOM 5162 C CA . ASN B 1 110 ? 20.762 -18.624 16.581 1.00 49.82 ? 110 ASN B CA 1 ATOM 5163 C C . ASN B 1 110 ? 20.359 -19.563 17.722 1.00 52.85 ? 110 ASN B C 1 ATOM 5164 O O . ASN B 1 110 ? 20.484 -20.783 17.597 1.00 52.82 ? 110 ASN B O 1 ATOM 5165 C CB . ASN B 1 110 ? 22.232 -18.831 16.207 1.00 51.18 ? 110 ASN B CB 1 ATOM 5166 C CG . ASN B 1 110 ? 22.572 -18.313 14.834 1.00 78.57 ? 110 ASN B CG 1 ATOM 5167 O OD1 . ASN B 1 110 ? 21.996 -18.728 13.816 1.00 69.85 ? 110 ASN B OD1 1 ATOM 5168 N ND2 . ASN B 1 110 ? 23.523 -17.392 14.777 1.00 74.07 ? 110 ASN B ND2 1 ATOM 5169 N N . LEU B 1 111 ? 19.868 -18.990 18.829 1.00 48.34 ? 111 LEU B N 1 ATOM 5170 C CA . LEU B 1 111 ? 19.423 -19.691 20.039 1.00 47.10 ? 111 LEU B CA 1 ATOM 5171 C C . LEU B 1 111 ? 20.574 -20.480 20.707 1.00 50.89 ? 111 LEU B C 1 ATOM 5172 O O . LEU B 1 111 ? 20.330 -21.459 21.422 1.00 50.69 ? 111 LEU B O 1 ATOM 5173 C CB . LEU B 1 111 ? 18.165 -20.562 19.779 1.00 46.44 ? 111 LEU B CB 1 ATOM 5174 C CG . LEU B 1 111 ? 17.028 -19.921 18.955 1.00 50.03 ? 111 LEU B CG 1 ATOM 5175 C CD1 . LEU B 1 111 ? 16.010 -20.937 18.547 1.00 49.18 ? 111 LEU B CD1 1 ATOM 5176 C CD2 . LEU B 1 111 ? 16.345 -18.820 19.697 1.00 51.92 ? 111 LEU B CD2 1 ATOM 5177 N N . SER B 1 112 ? 21.825 -19.997 20.517 1.00 46.93 ? 112 SER B N 1 ATOM 5178 C CA . SER B 1 112 ? 23.047 -20.603 21.047 1.00 46.80 ? 112 SER B CA 1 ATOM 5179 C C . SER B 1 112 ? 22.958 -20.828 22.544 1.00 51.41 ? 112 SER B C 1 ATOM 5180 O O . SER B 1 112 ? 22.533 -19.932 23.269 1.00 51.18 ? 112 SER B O 1 ATOM 5181 C CB . SER B 1 112 ? 24.273 -19.760 20.697 1.00 50.62 ? 112 SER B CB 1 ATOM 5182 O OG . SER B 1 112 ? 24.560 -18.763 21.667 1.00 61.58 ? 112 SER B OG 1 ATOM 5183 N N . SER B 1 113 ? 23.342 -22.034 22.992 1.00 48.89 ? 113 SER B N 1 ATOM 5184 C CA . SER B 1 113 ? 23.292 -22.475 24.389 1.00 48.84 ? 113 SER B CA 1 ATOM 5185 C C . SER B 1 113 ? 23.869 -21.462 25.361 1.00 51.60 ? 113 SER B C 1 ATOM 5186 O O . SER B 1 113 ? 23.204 -21.160 26.342 1.00 50.21 ? 113 SER B O 1 ATOM 5187 C CB . SER B 1 113 ? 23.958 -23.837 24.559 1.00 53.23 ? 113 SER B CB 1 ATOM 5188 O OG . SER B 1 113 ? 25.343 -23.747 24.275 1.00 67.52 ? 113 SER B OG 1 ATOM 5189 N N . LYS B 1 114 ? 25.066 -20.900 25.066 1.00 48.20 ? 114 LYS B N 1 ATOM 5190 C CA . LYS B 1 114 ? 25.709 -19.894 25.922 1.00 47.86 ? 114 LYS B CA 1 ATOM 5191 C C . LYS B 1 114 ? 24.741 -18.744 26.229 1.00 51.60 ? 114 LYS B C 1 ATOM 5192 O O . LYS B 1 114 ? 24.534 -18.417 27.401 1.00 50.58 ? 114 LYS B O 1 ATOM 5193 C CB . LYS B 1 114 ? 26.999 -19.348 25.278 1.00 49.72 ? 114 LYS B CB 1 ATOM 5194 C CG . LYS B 1 114 ? 27.859 -18.533 26.257 1.00 55.45 ? 114 LYS B CG 1 ATOM 5195 C CD . LYS B 1 114 ? 29.156 -18.089 25.646 1.00 67.83 ? 114 LYS B CD 1 ATOM 5196 C CE . LYS B 1 114 ? 30.105 -17.519 26.682 1.00 88.04 ? 114 LYS B CE 1 ATOM 5197 N NZ . LYS B 1 114 ? 31.489 -17.365 26.141 1.00 99.11 ? 114 LYS B NZ 1 ATOM 5198 N N . ALA B 1 115 ? 24.126 -18.175 25.162 1.00 48.42 ? 115 ALA B N 1 ATOM 5199 C CA . ALA B 1 115 ? 23.173 -17.065 25.211 1.00 47.69 ? 115 ALA B CA 1 ATOM 5200 C C . ALA B 1 115 ? 21.901 -17.452 25.943 1.00 50.74 ? 115 ALA B C 1 ATOM 5201 O O . ALA B 1 115 ? 21.570 -16.800 26.935 1.00 51.13 ? 115 ALA B O 1 ATOM 5202 C CB . ALA B 1 115 ? 22.854 -16.584 23.804 1.00 48.39 ? 115 ALA B CB 1 ATOM 5203 N N . VAL B 1 116 ? 21.215 -18.534 25.492 1.00 45.79 ? 116 VAL B N 1 ATOM 5204 C CA . VAL B 1 116 ? 19.966 -19.041 26.085 1.00 44.70 ? 116 VAL B CA 1 ATOM 5205 C C . VAL B 1 116 ? 20.141 -19.375 27.576 1.00 49.49 ? 116 VAL B C 1 ATOM 5206 O O . VAL B 1 116 ? 19.247 -19.058 28.356 1.00 49.53 ? 116 VAL B O 1 ATOM 5207 C CB . VAL B 1 116 ? 19.351 -20.203 25.271 1.00 47.35 ? 116 VAL B CB 1 ATOM 5208 C CG1 . VAL B 1 116 ? 18.141 -20.799 25.973 1.00 47.08 ? 116 VAL B CG1 1 ATOM 5209 C CG2 . VAL B 1 116 ? 18.955 -19.735 23.882 1.00 46.90 ? 116 VAL B CG2 1 ATOM 5210 N N . ASN B 1 117 ? 21.309 -19.944 27.972 1.00 46.64 ? 117 ASN B N 1 ATOM 5211 C CA . ASN B 1 117 ? 21.648 -20.274 29.368 1.00 46.18 ? 117 ASN B CA 1 ATOM 5212 C C . ASN B 1 117 ? 21.819 -19.001 30.178 1.00 47.39 ? 117 ASN B C 1 ATOM 5213 O O . ASN B 1 117 ? 21.346 -18.938 31.322 1.00 46.77 ? 117 ASN B O 1 ATOM 5214 C CB . ASN B 1 117 ? 22.918 -21.140 29.471 1.00 49.91 ? 117 ASN B CB 1 ATOM 5215 C CG . ASN B 1 117 ? 22.769 -22.598 29.054 1.00 69.70 ? 117 ASN B CG 1 ATOM 5216 O OD1 . ASN B 1 117 ? 21.743 -23.037 28.510 1.00 57.34 ? 117 ASN B OD1 1 ATOM 5217 N ND2 . ASN B 1 117 ? 23.825 -23.373 29.263 1.00 63.48 ? 117 ASN B ND2 1 ATOM 5218 N N . HIS B 1 118 ? 22.444 -17.968 29.571 1.00 42.50 ? 118 HIS B N 1 ATOM 5219 C CA . HIS B 1 118 ? 22.603 -16.674 30.233 1.00 42.02 ? 118 HIS B CA 1 ATOM 5220 C C . HIS B 1 118 ? 21.256 -15.962 30.413 1.00 46.27 ? 118 HIS B C 1 ATOM 5221 O O . HIS B 1 118 ? 20.966 -15.487 31.515 1.00 46.47 ? 118 HIS B O 1 ATOM 5222 C CB . HIS B 1 118 ? 23.611 -15.774 29.524 1.00 42.50 ? 118 HIS B CB 1 ATOM 5223 C CG . HIS B 1 118 ? 23.861 -14.507 30.276 1.00 45.92 ? 118 HIS B CG 1 ATOM 5224 N ND1 . HIS B 1 118 ? 23.631 -13.273 29.704 1.00 47.59 ? 118 HIS B ND1 1 ATOM 5225 C CD2 . HIS B 1 118 ? 24.238 -14.329 31.564 1.00 47.88 ? 118 HIS B CD2 1 ATOM 5226 C CE1 . HIS B 1 118 ? 23.910 -12.386 30.642 1.00 47.33 ? 118 HIS B CE1 1 ATOM 5227 N NE2 . HIS B 1 118 ? 24.279 -12.975 31.780 1.00 47.76 ? 118 HIS B NE2 1 ATOM 5228 N N . ILE B 1 119 ? 20.422 -15.932 29.345 1.00 41.47 ? 119 ILE B N 1 ATOM 5229 C CA . ILE B 1 119 ? 19.080 -15.326 29.341 1.00 39.98 ? 119 ILE B CA 1 ATOM 5230 C C . ILE B 1 119 ? 18.204 -15.959 30.438 1.00 44.77 ? 119 ILE B C 1 ATOM 5231 O O . ILE B 1 119 ? 17.478 -15.243 31.131 1.00 44.63 ? 119 ILE B O 1 ATOM 5232 C CB . ILE B 1 119 ? 18.457 -15.402 27.917 1.00 41.35 ? 119 ILE B CB 1 ATOM 5233 C CG1 . ILE B 1 119 ? 19.240 -14.491 26.937 1.00 39.91 ? 119 ILE B CG1 1 ATOM 5234 C CG2 . ILE B 1 119 ? 16.953 -15.054 27.933 1.00 41.43 ? 119 ILE B CG2 1 ATOM 5235 C CD1 . ILE B 1 119 ? 19.199 -14.913 25.469 1.00 32.50 ? 119 ILE B CD1 1 ATOM 5236 N N . HIS B 1 120 ? 18.320 -17.287 30.610 1.00 42.25 ? 120 HIS B N 1 ATOM 5237 C CA . HIS B 1 120 ? 17.613 -18.042 31.628 1.00 43.72 ? 120 HIS B CA 1 ATOM 5238 C C . HIS B 1 120 ? 18.060 -17.658 33.049 1.00 49.40 ? 120 HIS B C 1 ATOM 5239 O O . HIS B 1 120 ? 17.215 -17.633 33.945 1.00 50.69 ? 120 HIS B O 1 ATOM 5240 C CB . HIS B 1 120 ? 17.744 -19.547 31.396 1.00 45.38 ? 120 HIS B CB 1 ATOM 5241 C CG . HIS B 1 120 ? 16.706 -20.098 30.475 1.00 49.59 ? 120 HIS B CG 1 ATOM 5242 N ND1 . HIS B 1 120 ? 15.396 -20.275 30.888 1.00 51.96 ? 120 HIS B ND1 1 ATOM 5243 C CD2 . HIS B 1 120 ? 16.822 -20.527 29.201 1.00 51.74 ? 120 HIS B CD2 1 ATOM 5244 C CE1 . HIS B 1 120 ? 14.756 -20.781 29.845 1.00 51.48 ? 120 HIS B CE1 1 ATOM 5245 N NE2 . HIS B 1 120 ? 15.577 -20.958 28.810 1.00 51.79 ? 120 HIS B NE2 1 ATOM 5246 N N . SER B 1 121 ? 19.358 -17.327 33.257 1.00 44.43 ? 121 SER B N 1 ATOM 5247 C CA . SER B 1 121 ? 19.854 -16.916 34.574 1.00 43.72 ? 121 SER B CA 1 ATOM 5248 C C . SER B 1 121 ? 19.422 -15.473 34.943 1.00 47.89 ? 121 SER B C 1 ATOM 5249 O O . SER B 1 121 ? 19.162 -15.202 36.126 1.00 48.65 ? 121 SER B O 1 ATOM 5250 C CB . SER B 1 121 ? 21.369 -17.083 34.671 1.00 46.47 ? 121 SER B CB 1 ATOM 5251 O OG . SER B 1 121 ? 22.084 -15.969 34.163 1.00 54.67 ? 121 SER B OG 1 ATOM 5252 N N . VAL B 1 122 ? 19.350 -14.556 33.931 1.00 41.32 ? 122 VAL B N 1 ATOM 5253 C CA . VAL B 1 122 ? 18.927 -13.161 34.106 1.00 39.45 ? 122 VAL B CA 1 ATOM 5254 C C . VAL B 1 122 ? 17.445 -13.135 34.501 1.00 40.16 ? 122 VAL B C 1 ATOM 5255 O O . VAL B 1 122 ? 17.076 -12.453 35.461 1.00 38.94 ? 122 VAL B O 1 ATOM 5256 C CB . VAL B 1 122 ? 19.230 -12.290 32.858 1.00 43.67 ? 122 VAL B CB 1 ATOM 5257 C CG1 . VAL B 1 122 ? 18.694 -10.871 33.029 1.00 43.63 ? 122 VAL B CG1 1 ATOM 5258 C CG2 . VAL B 1 122 ? 20.728 -12.256 32.559 1.00 43.57 ? 122 VAL B CG2 1 ATOM 5259 N N . TRP B 1 123 ? 16.613 -13.931 33.792 1.00 35.79 ? 123 TRP B N 1 ATOM 5260 C CA . TRP B 1 123 ? 15.183 -14.080 34.050 1.00 35.00 ? 123 TRP B CA 1 ATOM 5261 C C . TRP B 1 123 ? 14.934 -14.562 35.502 1.00 37.73 ? 123 TRP B C 1 ATOM 5262 O O . TRP B 1 123 ? 14.111 -13.974 36.208 1.00 37.26 ? 123 TRP B O 1 ATOM 5263 C CB . TRP B 1 123 ? 14.556 -15.023 33.014 1.00 33.87 ? 123 TRP B CB 1 ATOM 5264 C CG . TRP B 1 123 ? 13.061 -15.121 33.117 1.00 35.47 ? 123 TRP B CG 1 ATOM 5265 C CD1 . TRP B 1 123 ? 12.339 -16.140 33.670 1.00 38.27 ? 123 TRP B CD1 1 ATOM 5266 C CD2 . TRP B 1 123 ? 12.109 -14.124 32.718 1.00 35.89 ? 123 TRP B CD2 1 ATOM 5267 N NE1 . TRP B 1 123 ? 10.997 -15.847 33.628 1.00 37.82 ? 123 TRP B NE1 1 ATOM 5268 C CE2 . TRP B 1 123 ? 10.825 -14.615 33.048 1.00 39.65 ? 123 TRP B CE2 1 ATOM 5269 C CE3 . TRP B 1 123 ? 12.218 -12.839 32.149 1.00 37.65 ? 123 TRP B CE3 1 ATOM 5270 C CZ2 . TRP B 1 123 ? 9.656 -13.879 32.803 1.00 39.21 ? 123 TRP B CZ2 1 ATOM 5271 C CZ3 . TRP B 1 123 ? 11.056 -12.121 31.889 1.00 39.19 ? 123 TRP B CZ3 1 ATOM 5272 C CH2 . TRP B 1 123 ? 9.794 -12.645 32.205 1.00 39.66 ? 123 TRP B CH2 1 ATOM 5273 N N . LYS B 1 124 ? 15.693 -15.589 35.952 1.00 33.29 ? 124 LYS B N 1 ATOM 5274 C CA . LYS B 1 124 ? 15.627 -16.167 37.296 1.00 32.76 ? 124 LYS B CA 1 ATOM 5275 C C . LYS B 1 124 ? 15.956 -15.079 38.300 1.00 37.00 ? 124 LYS B C 1 ATOM 5276 O O . LYS B 1 124 ? 15.245 -14.914 39.283 1.00 36.54 ? 124 LYS B O 1 ATOM 5277 C CB . LYS B 1 124 ? 16.626 -17.330 37.422 1.00 35.01 ? 124 LYS B CB 1 ATOM 5278 C CG . LYS B 1 124 ? 16.385 -18.237 38.619 1.00 46.96 ? 124 LYS B CG 1 ATOM 5279 C CD . LYS B 1 124 ? 17.180 -19.534 38.525 1.00 58.07 ? 124 LYS B CD 1 ATOM 5280 C CE . LYS B 1 124 ? 16.588 -20.672 39.346 1.00 62.32 ? 124 LYS B CE 1 ATOM 5281 N NZ . LYS B 1 124 ? 17.018 -20.628 40.765 1.00 61.34 ? 124 LYS B NZ 1 ATOM 5282 N N . ASP B 1 125 ? 17.013 -14.306 38.015 1.00 34.48 ? 125 ASP B N 1 ATOM 5283 C CA . ASP B 1 125 ? 17.464 -13.184 38.840 1.00 34.36 ? 125 ASP B CA 1 ATOM 5284 C C . ASP B 1 125 ? 16.345 -12.119 38.945 1.00 39.02 ? 125 ASP B C 1 ATOM 5285 O O . ASP B 1 125 ? 16.041 -11.667 40.050 1.00 37.05 ? 125 ASP B O 1 ATOM 5286 C CB . ASP B 1 125 ? 18.774 -12.600 38.270 1.00 35.01 ? 125 ASP B CB 1 ATOM 5287 C CG . ASP B 1 125 ? 19.340 -11.442 39.050 1.00 35.66 ? 125 ASP B CG 1 ATOM 5288 O OD1 . ASP B 1 125 ? 18.858 -10.318 38.862 1.00 34.74 ? 125 ASP B OD1 1 ATOM 5289 O OD2 . ASP B 1 125 ? 20.294 -11.658 39.821 1.00 38.22 ? 125 ASP B OD2 1 ATOM 5290 N N . LEU B 1 126 ? 15.698 -11.765 37.813 1.00 36.98 ? 126 LEU B N 1 ATOM 5291 C CA . LEU B 1 126 ? 14.598 -10.797 37.853 1.00 37.49 ? 126 LEU B CA 1 ATOM 5292 C C . LEU B 1 126 ? 13.458 -11.312 38.765 1.00 43.30 ? 126 LEU B C 1 ATOM 5293 O O . LEU B 1 126 ? 12.981 -10.567 39.616 1.00 42.60 ? 126 LEU B O 1 ATOM 5294 C CB . LEU B 1 126 ? 14.090 -10.456 36.437 1.00 37.28 ? 126 LEU B CB 1 ATOM 5295 C CG . LEU B 1 126 ? 15.077 -9.700 35.523 1.00 41.57 ? 126 LEU B CG 1 ATOM 5296 C CD1 . LEU B 1 126 ? 14.597 -9.677 34.093 1.00 41.37 ? 126 LEU B CD1 1 ATOM 5297 C CD2 . LEU B 1 126 ? 15.356 -8.291 36.030 1.00 42.84 ? 126 LEU B CD2 1 ATOM 5298 N N . LEU B 1 127 ? 13.113 -12.614 38.660 1.00 40.28 ? 127 LEU B N 1 ATOM 5299 C CA . LEU B 1 127 ? 12.061 -13.239 39.461 1.00 39.68 ? 127 LEU B CA 1 ATOM 5300 C C . LEU B 1 127 ? 12.381 -13.345 40.946 1.00 44.85 ? 127 LEU B C 1 ATOM 5301 O O . LEU B 1 127 ? 11.466 -13.296 41.769 1.00 45.15 ? 127 LEU B O 1 ATOM 5302 C CB . LEU B 1 127 ? 11.683 -14.608 38.896 1.00 39.46 ? 127 LEU B CB 1 ATOM 5303 C CG . LEU B 1 127 ? 11.062 -14.643 37.498 1.00 43.94 ? 127 LEU B CG 1 ATOM 5304 C CD1 . LEU B 1 127 ? 10.800 -16.052 37.078 1.00 43.83 ? 127 LEU B CD1 1 ATOM 5305 C CD2 . LEU B 1 127 ? 9.763 -13.862 37.436 1.00 46.24 ? 127 LEU B CD2 1 ATOM 5306 N N . GLU B 1 128 ? 13.665 -13.452 41.297 1.00 42.24 ? 128 GLU B N 1 ATOM 5307 C CA . GLU B 1 128 ? 14.105 -13.587 42.692 1.00 41.58 ? 128 GLU B CA 1 ATOM 5308 C C . GLU B 1 128 ? 14.771 -12.336 43.289 1.00 43.02 ? 128 GLU B C 1 ATOM 5309 O O . GLU B 1 128 ? 15.187 -12.377 44.443 1.00 43.55 ? 128 GLU B O 1 ATOM 5310 C CB . GLU B 1 128 ? 15.030 -14.809 42.846 1.00 43.41 ? 128 GLU B CB 1 ATOM 5311 C CG . GLU B 1 128 ? 14.516 -16.135 42.275 1.00 60.88 ? 128 GLU B CG 1 ATOM 5312 C CD . GLU B 1 128 ? 13.085 -16.595 42.542 1.00 96.52 ? 128 GLU B CD 1 ATOM 5313 O OE1 . GLU B 1 128 ? 12.749 -16.856 43.721 1.00 100.08 ? 128 GLU B OE1 1 ATOM 5314 O OE2 . GLU B 1 128 ? 12.312 -16.733 41.565 1.00 93.94 ? 128 GLU B OE2 1 ATOM 5315 N N . ASP B 1 129 ? 14.861 -11.230 42.536 1.00 37.84 ? 129 ASP B N 1 ATOM 5316 C CA . ASP B 1 129 ? 15.497 -9.996 43.012 1.00 37.15 ? 129 ASP B CA 1 ATOM 5317 C C . ASP B 1 129 ? 14.755 -8.778 42.451 1.00 41.16 ? 129 ASP B C 1 ATOM 5318 O O . ASP B 1 129 ? 14.678 -8.619 41.234 1.00 40.75 ? 129 ASP B O 1 ATOM 5319 C CB . ASP B 1 129 ? 16.975 -10.000 42.574 1.00 38.32 ? 129 ASP B CB 1 ATOM 5320 C CG . ASP B 1 129 ? 17.927 -9.034 43.237 1.00 41.90 ? 129 ASP B CG 1 ATOM 5321 O OD1 . ASP B 1 129 ? 17.472 -7.963 43.697 1.00 41.77 ? 129 ASP B OD1 1 ATOM 5322 O OD2 . ASP B 1 129 ? 19.140 -9.298 43.205 1.00 48.24 ? 129 ASP B OD2 1 ATOM 5323 N N . THR B 1 130 ? 14.174 -7.943 43.333 1.00 37.78 ? 130 THR B N 1 ATOM 5324 C CA . THR B 1 130 ? 13.423 -6.743 42.901 1.00 37.71 ? 130 THR B CA 1 ATOM 5325 C C . THR B 1 130 ? 14.003 -5.414 43.467 1.00 39.86 ? 130 THR B C 1 ATOM 5326 O O . THR B 1 130 ? 13.327 -4.388 43.381 1.00 37.38 ? 130 THR B O 1 ATOM 5327 C CB . THR B 1 130 ? 11.900 -6.866 43.246 1.00 46.37 ? 130 THR B CB 1 ATOM 5328 O OG1 . THR B 1 130 ? 11.705 -6.682 44.646 1.00 50.28 ? 130 THR B OG1 1 ATOM 5329 C CG2 . THR B 1 130 ? 11.265 -8.191 42.806 1.00 43.31 ? 130 THR B CG2 1 ATOM 5330 N N A VAL B 1 131 ? 15.224 -5.454 44.046 0.50 37.49 ? 131 VAL B N 1 ATOM 5331 N N B VAL B 1 131 ? 15.232 -5.438 44.041 0.50 36.67 ? 131 VAL B N 1 ATOM 5332 C CA A VAL B 1 131 ? 15.863 -4.297 44.687 0.50 37.45 ? 131 VAL B CA 1 ATOM 5333 C CA B VAL B 1 131 ? 15.849 -4.253 44.666 0.50 36.23 ? 131 VAL B CA 1 ATOM 5334 C C A VAL B 1 131 ? 17.180 -3.867 44.011 0.50 42.13 ? 131 VAL B C 1 ATOM 5335 C C B VAL B 1 131 ? 17.219 -3.859 44.069 0.50 41.54 ? 131 VAL B C 1 ATOM 5336 O O A VAL B 1 131 ? 17.424 -2.667 43.892 0.50 42.47 ? 131 VAL B O 1 ATOM 5337 O O B VAL B 1 131 ? 17.535 -2.669 44.066 0.50 41.80 ? 131 VAL B O 1 ATOM 5338 C CB A VAL B 1 131 ? 16.071 -4.505 46.221 0.50 41.20 ? 131 VAL B CB 1 ATOM 5339 C CB B VAL B 1 131 ? 15.934 -4.355 46.215 0.50 39.29 ? 131 VAL B CB 1 ATOM 5340 C CG1 A VAL B 1 131 ? 16.239 -3.172 46.936 0.50 41.20 ? 131 VAL B CG1 1 ATOM 5341 C CG1 B VAL B 1 131 ? 14.555 -4.216 46.856 0.50 39.05 ? 131 VAL B CG1 1 ATOM 5342 C CG2 A VAL B 1 131 ? 14.932 -5.299 46.858 0.50 41.00 ? 131 VAL B CG2 1 ATOM 5343 C CG2 B VAL B 1 131 ? 16.623 -5.641 46.670 0.50 38.87 ? 131 VAL B CG2 1 ATOM 5344 N N . THR B 1 132 ? 18.037 -4.830 43.612 1.00 38.20 ? 132 THR B N 1 ATOM 5345 C CA . THR B 1 132 ? 19.371 -4.549 43.035 1.00 37.86 ? 132 THR B CA 1 ATOM 5346 C C . THR B 1 132 ? 19.353 -3.766 41.736 1.00 42.00 ? 132 THR B C 1 ATOM 5347 O O . THR B 1 132 ? 18.934 -4.350 40.735 1.00 43.44 ? 132 THR B O 1 ATOM 5348 C CB . THR B 1 132 ? 20.198 -5.825 42.838 1.00 43.58 ? 132 THR B CB 1 ATOM 5349 O OG1 . THR B 1 132 ? 19.893 -6.763 43.863 1.00 42.02 ? 132 THR B OG1 1 ATOM 5350 C CG2 . THR B 1 132 ? 21.695 -5.541 42.801 1.00 41.93 ? 132 THR B CG2 1 ATOM 5351 N N . PRO B 1 133 ? 19.871 -2.499 41.679 1.00 36.38 ? 133 PRO B N 1 ATOM 5352 C CA . PRO B 1 133 ? 19.883 -1.771 40.389 1.00 35.22 ? 133 PRO B CA 1 ATOM 5353 C C . PRO B 1 133 ? 20.674 -2.502 39.299 1.00 35.77 ? 133 PRO B C 1 ATOM 5354 O O . PRO B 1 133 ? 21.765 -3.030 39.566 1.00 34.97 ? 133 PRO B O 1 ATOM 5355 C CB . PRO B 1 133 ? 20.496 -0.411 40.749 1.00 36.18 ? 133 PRO B CB 1 ATOM 5356 C CG . PRO B 1 133 ? 20.285 -0.280 42.203 1.00 40.06 ? 133 PRO B CG 1 ATOM 5357 C CD . PRO B 1 133 ? 20.431 -1.656 42.750 1.00 36.29 ? 133 PRO B CD 1 ATOM 5358 N N . ILE B 1 134 ? 20.059 -2.616 38.111 1.00 29.07 ? 134 ILE B N 1 ATOM 5359 C CA . ILE B 1 134 ? 20.644 -3.277 36.953 1.00 28.51 ? 134 ILE B CA 1 ATOM 5360 C C . ILE B 1 134 ? 21.617 -2.308 36.281 1.00 36.16 ? 134 ILE B C 1 ATOM 5361 O O . ILE B 1 134 ? 21.274 -1.140 36.041 1.00 35.86 ? 134 ILE B O 1 ATOM 5362 C CB . ILE B 1 134 ? 19.542 -3.819 35.991 1.00 30.32 ? 134 ILE B CB 1 ATOM 5363 C CG1 . ILE B 1 134 ? 18.818 -5.018 36.627 1.00 30.19 ? 134 ILE B CG1 1 ATOM 5364 C CG2 . ILE B 1 134 ? 20.093 -4.175 34.594 1.00 29.41 ? 134 ILE B CG2 1 ATOM 5365 C CD1 . ILE B 1 134 ? 17.432 -5.250 36.148 1.00 34.24 ? 134 ILE B CD1 1 ATOM 5366 N N . ASP B 1 135 ? 22.841 -2.798 35.997 1.00 34.19 ? 135 ASP B N 1 ATOM 5367 C CA . ASP B 1 135 ? 23.879 -2.012 35.337 1.00 34.20 ? 135 ASP B CA 1 ATOM 5368 C C . ASP B 1 135 ? 23.473 -1.686 33.894 1.00 39.38 ? 135 ASP B C 1 ATOM 5369 O O . ASP B 1 135 ? 22.953 -2.554 33.164 1.00 38.44 ? 135 ASP B O 1 ATOM 5370 C CB . ASP B 1 135 ? 25.217 -2.758 35.339 1.00 35.90 ? 135 ASP B CB 1 ATOM 5371 C CG . ASP B 1 135 ? 26.292 -1.995 34.604 1.00 49.12 ? 135 ASP B CG 1 ATOM 5372 O OD1 . ASP B 1 135 ? 26.605 -0.855 35.030 1.00 49.98 ? 135 ASP B OD1 1 ATOM 5373 O OD2 . ASP B 1 135 ? 26.740 -2.480 33.540 1.00 55.41 ? 135 ASP B OD2 1 ATOM 5374 N N . THR B 1 136 ? 23.714 -0.423 33.497 1.00 36.31 ? 136 THR B N 1 ATOM 5375 C CA . THR B 1 136 ? 23.420 0.084 32.156 1.00 35.71 ? 136 THR B CA 1 ATOM 5376 C C . THR B 1 136 ? 24.696 0.655 31.534 1.00 39.14 ? 136 THR B C 1 ATOM 5377 O O . THR B 1 136 ? 25.668 0.914 32.240 1.00 38.57 ? 136 THR B O 1 ATOM 5378 C CB . THR B 1 136 ? 22.296 1.136 32.209 1.00 44.98 ? 136 THR B CB 1 ATOM 5379 O OG1 . THR B 1 136 ? 22.771 2.321 32.850 1.00 43.18 ? 136 THR B OG1 1 ATOM 5380 C CG2 . THR B 1 136 ? 21.058 0.649 32.939 1.00 45.85 ? 136 THR B CG2 1 ATOM 5381 N N . THR B 1 137 ? 24.681 0.892 30.223 1.00 35.74 ? 137 THR B N 1 ATOM 5382 C CA . THR B 1 137 ? 25.823 1.472 29.536 1.00 35.08 ? 137 THR B CA 1 ATOM 5383 C C . THR B 1 137 ? 25.454 2.841 28.983 1.00 40.78 ? 137 THR B C 1 ATOM 5384 O O . THR B 1 137 ? 24.437 2.975 28.309 1.00 40.70 ? 137 THR B O 1 ATOM 5385 C CB . THR B 1 137 ? 26.376 0.469 28.516 1.00 37.66 ? 137 THR B CB 1 ATOM 5386 O OG1 . THR B 1 137 ? 26.905 -0.630 29.262 1.00 40.27 ? 137 THR B OG1 1 ATOM 5387 C CG2 . THR B 1 137 ? 27.468 1.060 27.608 1.00 28.65 ? 137 THR B CG2 1 ATOM 5388 N N . ILE B 1 138 ? 26.249 3.864 29.317 1.00 39.42 ? 138 ILE B N 1 ATOM 5389 C CA . ILE B 1 138 ? 26.049 5.219 28.797 1.00 40.20 ? 138 ILE B CA 1 ATOM 5390 C C . ILE B 1 138 ? 26.981 5.411 27.603 1.00 48.69 ? 138 ILE B C 1 ATOM 5391 O O . ILE B 1 138 ? 28.180 5.096 27.683 1.00 48.57 ? 138 ILE B O 1 ATOM 5392 C CB . ILE B 1 138 ? 26.121 6.352 29.853 1.00 42.39 ? 138 ILE B CB 1 ATOM 5393 C CG1 . ILE B 1 138 ? 25.685 7.692 29.231 1.00 42.20 ? 138 ILE B CG1 1 ATOM 5394 C CG2 . ILE B 1 138 ? 27.504 6.435 30.559 1.00 42.06 ? 138 ILE B CG2 1 ATOM 5395 C CD1 . ILE B 1 138 ? 24.889 8.564 30.101 1.00 48.36 ? 138 ILE B CD1 1 ATOM 5396 N N . MET B 1 139 ? 26.400 5.843 26.465 1.00 47.23 ? 139 MET B N 1 ATOM 5397 C CA . MET B 1 139 ? 27.118 6.019 25.197 1.00 46.51 ? 139 MET B CA 1 ATOM 5398 C C . MET B 1 139 ? 26.626 7.214 24.422 1.00 47.50 ? 139 MET B C 1 ATOM 5399 O O . MET B 1 139 ? 25.425 7.476 24.390 1.00 48.24 ? 139 MET B O 1 ATOM 5400 C CB . MET B 1 139 ? 26.979 4.767 24.310 1.00 48.94 ? 139 MET B CB 1 ATOM 5401 C CG . MET B 1 139 ? 27.819 3.634 24.755 1.00 53.22 ? 139 MET B CG 1 ATOM 5402 S SD . MET B 1 139 ? 28.731 2.839 23.437 1.00 58.62 ? 139 MET B SD 1 ATOM 5403 C CE . MET B 1 139 ? 28.769 1.194 24.089 1.00 55.79 ? 139 MET B CE 1 ATOM 5404 N N . ALA B 1 140 ? 27.549 7.907 23.751 1.00 41.14 ? 140 ALA B N 1 ATOM 5405 C CA . ALA B 1 140 ? 27.198 9.016 22.890 1.00 40.17 ? 140 ALA B CA 1 ATOM 5406 C C . ALA B 1 140 ? 26.832 8.432 21.530 1.00 44.98 ? 140 ALA B C 1 ATOM 5407 O O . ALA B 1 140 ? 27.550 7.566 21.005 1.00 44.70 ? 140 ALA B O 1 ATOM 5408 C CB . ALA B 1 140 ? 28.359 9.981 22.761 1.00 40.59 ? 140 ALA B CB 1 ATOM 5409 N N . LYS B 1 141 ? 25.673 8.855 20.992 1.00 41.50 ? 141 LYS B N 1 ATOM 5410 C CA . LYS B 1 141 ? 25.185 8.411 19.691 1.00 40.51 ? 141 LYS B CA 1 ATOM 5411 C C . LYS B 1 141 ? 26.012 9.066 18.609 1.00 42.96 ? 141 LYS B C 1 ATOM 5412 O O . LYS B 1 141 ? 26.509 10.170 18.810 1.00 41.71 ? 141 LYS B O 1 ATOM 5413 C CB . LYS B 1 141 ? 23.709 8.794 19.504 1.00 42.56 ? 141 LYS B CB 1 ATOM 5414 C CG . LYS B 1 141 ? 22.722 7.891 20.226 1.00 49.37 ? 141 LYS B CG 1 ATOM 5415 C CD . LYS B 1 141 ? 21.302 8.180 19.764 1.00 59.92 ? 141 LYS B CD 1 ATOM 5416 C CE . LYS B 1 141 ? 20.255 7.502 20.611 1.00 81.51 ? 141 LYS B CE 1 ATOM 5417 N NZ . LYS B 1 141 ? 20.139 8.120 21.958 1.00 96.08 ? 141 LYS B NZ 1 ATOM 5418 N N . ASN B 1 142 ? 26.175 8.383 17.472 1.00 40.09 ? 142 ASN B N 1 ATOM 5419 C CA . ASN B 1 142 ? 26.868 8.948 16.316 1.00 39.90 ? 142 ASN B CA 1 ATOM 5420 C C . ASN B 1 142 ? 25.797 9.202 15.274 1.00 43.73 ? 142 ASN B C 1 ATOM 5421 O O . ASN B 1 142 ? 25.432 8.278 14.530 1.00 43.38 ? 142 ASN B O 1 ATOM 5422 C CB . ASN B 1 142 ? 27.965 8.022 15.775 1.00 39.98 ? 142 ASN B CB 1 ATOM 5423 C CG . ASN B 1 142 ? 29.148 7.813 16.688 1.00 58.34 ? 142 ASN B CG 1 ATOM 5424 O OD1 . ASN B 1 142 ? 29.622 6.690 16.849 1.00 59.28 ? 142 ASN B OD1 1 ATOM 5425 N ND2 . ASN B 1 142 ? 29.690 8.877 17.266 1.00 42.13 ? 142 ASN B ND2 1 ATOM 5426 N N . GLU B 1 143 ? 25.222 10.435 15.292 1.00 39.16 ? 143 GLU B N 1 ATOM 5427 C CA . GLU B 1 143 ? 24.163 10.870 14.379 1.00 38.04 ? 143 GLU B CA 1 ATOM 5428 C C . GLU B 1 143 ? 24.625 11.990 13.466 1.00 40.86 ? 143 GLU B C 1 ATOM 5429 O O . GLU B 1 143 ? 25.419 12.836 13.873 1.00 39.61 ? 143 GLU B O 1 ATOM 5430 C CB . GLU B 1 143 ? 22.906 11.277 15.146 1.00 39.45 ? 143 GLU B CB 1 ATOM 5431 C CG . GLU B 1 143 ? 22.175 10.092 15.747 1.00 50.27 ? 143 GLU B CG 1 ATOM 5432 C CD . GLU B 1 143 ? 21.074 10.425 16.732 1.00 74.46 ? 143 GLU B CD 1 ATOM 5433 O OE1 . GLU B 1 143 ? 21.258 11.355 17.553 1.00 57.94 ? 143 GLU B OE1 1 ATOM 5434 O OE2 . GLU B 1 143 ? 20.045 9.711 16.721 1.00 76.55 ? 143 GLU B OE2 1 ATOM 5435 N N . VAL B 1 144 ? 24.109 12.002 12.234 1.00 38.47 ? 144 VAL B N 1 ATOM 5436 C CA . VAL B 1 144 ? 24.470 12.977 11.202 1.00 38.49 ? 144 VAL B CA 1 ATOM 5437 C C . VAL B 1 144 ? 23.462 14.148 11.115 1.00 43.00 ? 144 VAL B C 1 ATOM 5438 O O . VAL B 1 144 ? 22.253 13.940 11.036 1.00 41.56 ? 144 VAL B O 1 ATOM 5439 C CB . VAL B 1 144 ? 24.690 12.269 9.832 1.00 42.16 ? 144 VAL B CB 1 ATOM 5440 C CG1 . VAL B 1 144 ? 25.165 13.238 8.762 1.00 42.08 ? 144 VAL B CG1 1 ATOM 5441 C CG2 . VAL B 1 144 ? 25.663 11.103 9.958 1.00 41.93 ? 144 VAL B CG2 1 ATOM 5442 N N . PHE B 1 145 ? 23.986 15.381 11.120 1.00 42.44 ? 145 PHE B N 1 ATOM 5443 C CA . PHE B 1 145 ? 23.203 16.619 10.971 1.00 43.17 ? 145 PHE B CA 1 ATOM 5444 C C . PHE B 1 145 ? 23.897 17.641 10.029 1.00 47.30 ? 145 PHE B C 1 ATOM 5445 O O . PHE B 1 145 ? 25.070 17.483 9.676 1.00 47.49 ? 145 PHE B O 1 ATOM 5446 C CB . PHE B 1 145 ? 22.926 17.283 12.341 1.00 44.99 ? 145 PHE B CB 1 ATOM 5447 C CG . PHE B 1 145 ? 22.369 16.383 13.406 1.00 46.75 ? 145 PHE B CG 1 ATOM 5448 C CD1 . PHE B 1 145 ? 21.019 16.057 13.428 1.00 50.11 ? 145 PHE B CD1 1 ATOM 5449 C CD2 . PHE B 1 145 ? 23.194 15.863 14.401 1.00 49.33 ? 145 PHE B CD2 1 ATOM 5450 C CE1 . PHE B 1 145 ? 20.506 15.201 14.414 1.00 51.16 ? 145 PHE B CE1 1 ATOM 5451 C CE2 . PHE B 1 145 ? 22.684 15.005 15.384 1.00 51.74 ? 145 PHE B CE2 1 ATOM 5452 C CZ . PHE B 1 145 ? 21.344 14.681 15.384 1.00 49.84 ? 145 PHE B CZ 1 ATOM 5453 N N . CYS B 1 146 ? 23.150 18.683 9.643 1.00 43.14 ? 146 CYS B N 1 ATOM 5454 C CA . CYS B 1 146 ? 23.607 19.840 8.879 1.00 43.08 ? 146 CYS B CA 1 ATOM 5455 C C . CYS B 1 146 ? 23.880 20.943 9.934 1.00 49.28 ? 146 CYS B C 1 ATOM 5456 O O . CYS B 1 146 ? 23.319 20.874 11.034 1.00 49.64 ? 146 CYS B O 1 ATOM 5457 C CB . CYS B 1 146 ? 22.525 20.261 7.886 1.00 43.02 ? 146 CYS B CB 1 ATOM 5458 S SG . CYS B 1 146 ? 22.959 21.680 6.842 1.00 46.83 ? 146 CYS B SG 1 ATOM 5459 N N . VAL B 1 147 ? 24.734 21.936 9.641 1.00 47.05 ? 147 VAL B N 1 ATOM 5460 C CA . VAL B 1 147 ? 24.992 22.971 10.657 1.00 47.63 ? 147 VAL B CA 1 ATOM 5461 C C . VAL B 1 147 ? 23.819 23.980 10.752 1.00 52.69 ? 147 VAL B C 1 ATOM 5462 O O . VAL B 1 147 ? 23.237 24.368 9.726 1.00 52.68 ? 147 VAL B O 1 ATOM 5463 C CB . VAL B 1 147 ? 26.374 23.675 10.566 1.00 51.70 ? 147 VAL B CB 1 ATOM 5464 C CG1 . VAL B 1 147 ? 27.518 22.682 10.730 1.00 51.46 ? 147 VAL B CG1 1 ATOM 5465 C CG2 . VAL B 1 147 ? 26.531 24.465 9.280 1.00 51.87 ? 147 VAL B CG2 1 ATOM 5466 N N . GLN B 1 148 ? 23.476 24.363 12.016 1.00 48.88 ? 148 GLN B N 1 ATOM 5467 C CA . GLN B 1 148 ? 22.409 25.286 12.428 1.00 68.23 ? 148 GLN B CA 1 ATOM 5468 C C . GLN B 1 148 ? 21.050 24.873 11.866 1.00 107.93 ? 148 GLN B C 1 ATOM 5469 O O . GLN B 1 148 ? 20.560 23.798 12.206 1.00 70.66 ? 148 GLN B O 1 ATOM 5470 C CB . GLN B 1 148 ? 22.758 26.756 12.118 1.00 69.34 ? 148 GLN B CB 1 ATOM 5471 C CG . GLN B 1 148 ? 21.759 27.783 12.695 1.00 79.48 ? 148 GLN B CG 1 ATOM 5472 C CD . GLN B 1 148 ? 22.389 28.830 13.593 1.00 91.88 ? 148 GLN B CD 1 ATOM 5473 O OE1 . GLN B 1 148 ? 23.339 29.522 13.216 1.00 86.46 ? 148 GLN B OE1 1 ATOM 5474 N NE2 . GLN B 1 148 ? 21.827 29.020 14.783 1.00 79.57 ? 148 GLN B NE2 1 ATOM 5475 N N . ARG B 1 154 ? 26.034 23.407 15.545 1.00 44.91 ? 154 ARG B N 1 ATOM 5476 C CA . ARG B 1 154 ? 26.473 22.049 15.882 1.00 44.31 ? 154 ARG B CA 1 ATOM 5477 C C . ARG B 1 154 ? 25.902 21.546 17.204 1.00 47.08 ? 154 ARG B C 1 ATOM 5478 O O . ARG B 1 154 ? 26.279 22.043 18.264 1.00 48.00 ? 154 ARG B O 1 ATOM 5479 C CB . ARG B 1 154 ? 28.010 21.942 15.845 1.00 44.65 ? 154 ARG B CB 1 ATOM 5480 C CG . ARG B 1 154 ? 28.541 21.243 14.609 1.00 54.22 ? 154 ARG B CG 1 ATOM 5481 C CD . ARG B 1 154 ? 30.005 21.537 14.349 1.00 68.60 ? 154 ARG B CD 1 ATOM 5482 N NE . ARG B 1 154 ? 30.218 21.839 12.933 1.00 76.72 ? 154 ARG B NE 1 ATOM 5483 C CZ . ARG B 1 154 ? 30.968 21.116 12.109 1.00 86.98 ? 154 ARG B CZ 1 ATOM 5484 N NH1 . ARG B 1 154 ? 31.615 20.047 12.554 1.00 73.17 ? 154 ARG B NH1 1 ATOM 5485 N NH2 . ARG B 1 154 ? 31.093 21.468 10.834 1.00 70.12 ? 154 ARG B NH2 1 ATOM 5486 N N . LYS B 1 155 ? 24.994 20.555 17.133 1.00 41.90 ? 155 LYS B N 1 ATOM 5487 C CA . LYS B 1 155 ? 24.330 19.900 18.271 1.00 40.80 ? 155 LYS B CA 1 ATOM 5488 C C . LYS B 1 155 ? 25.289 18.988 19.083 1.00 45.09 ? 155 LYS B C 1 ATOM 5489 O O . LYS B 1 155 ? 26.052 18.229 18.468 1.00 44.37 ? 155 LYS B O 1 ATOM 5490 C CB . LYS B 1 155 ? 23.164 19.020 17.771 1.00 42.30 ? 155 LYS B CB 1 ATOM 5491 C CG . LYS B 1 155 ? 22.046 19.776 17.075 1.00 60.42 ? 155 LYS B CG 1 ATOM 5492 C CD . LYS B 1 155 ? 20.975 18.847 16.502 1.00 70.06 ? 155 LYS B CD 1 ATOM 5493 C CE . LYS B 1 155 ? 19.833 19.644 15.906 1.00 78.48 ? 155 LYS B CE 1 ATOM 5494 N NZ . LYS B 1 155 ? 18.890 18.795 15.131 1.00 83.89 ? 155 LYS B NZ 1 ATOM 5495 N N . PRO B 1 156 ? 25.222 18.966 20.454 1.00 41.27 ? 156 PRO B N 1 ATOM 5496 C CA . PRO B 1 156 ? 26.038 17.985 21.198 1.00 39.59 ? 156 PRO B CA 1 ATOM 5497 C C . PRO B 1 156 ? 25.415 16.595 21.035 1.00 41.57 ? 156 PRO B C 1 ATOM 5498 O O . PRO B 1 156 ? 24.199 16.489 20.810 1.00 40.66 ? 156 PRO B O 1 ATOM 5499 C CB . PRO B 1 156 ? 25.977 18.480 22.650 1.00 40.94 ? 156 PRO B CB 1 ATOM 5500 C CG . PRO B 1 156 ? 24.775 19.314 22.738 1.00 45.57 ? 156 PRO B CG 1 ATOM 5501 C CD . PRO B 1 156 ? 24.346 19.742 21.365 1.00 41.95 ? 156 PRO B CD 1 ATOM 5502 N N . ALA B 1 157 ? 26.241 15.535 21.133 1.00 36.85 ? 157 ALA B N 1 ATOM 5503 C CA . ALA B 1 157 ? 25.804 14.140 20.994 1.00 35.69 ? 157 ALA B CA 1 ATOM 5504 C C . ALA B 1 157 ? 24.613 13.781 21.869 1.00 38.77 ? 157 ALA B C 1 ATOM 5505 O O . ALA B 1 157 ? 24.514 14.238 22.996 1.00 37.01 ? 157 ALA B O 1 ATOM 5506 C CB . ALA B 1 157 ? 26.954 13.201 21.300 1.00 36.15 ? 157 ALA B CB 1 ATOM 5507 N N . ARG B 1 158 ? 23.698 12.984 21.337 1.00 37.27 ? 158 ARG B N 1 ATOM 5508 C CA . ARG B 1 158 ? 22.563 12.473 22.106 1.00 37.55 ? 158 ARG B CA 1 ATOM 5509 C C . ARG B 1 158 ? 23.073 11.262 22.886 1.00 42.50 ? 158 ARG B C 1 ATOM 5510 O O . ARG B 1 158 ? 23.994 10.584 22.429 1.00 42.33 ? 158 ARG B O 1 ATOM 5511 C CB . ARG B 1 158 ? 21.407 12.050 21.191 1.00 37.14 ? 158 ARG B CB 1 ATOM 5512 C CG . ARG B 1 158 ? 20.483 13.184 20.804 1.00 49.28 ? 158 ARG B CG 1 ATOM 5513 C CD . ARG B 1 158 ? 19.037 12.716 20.813 1.00 67.02 ? 158 ARG B CD 1 ATOM 5514 N NE . ARG B 1 158 ? 18.690 11.898 19.645 1.00 81.90 ? 158 ARG B NE 1 ATOM 5515 C CZ . ARG B 1 158 ? 17.697 11.010 19.617 1.00 96.49 ? 158 ARG B CZ 1 ATOM 5516 N NH1 . ARG B 1 158 ? 16.954 10.799 20.697 1.00 78.82 ? 158 ARG B NH1 1 ATOM 5517 N NH2 . ARG B 1 158 ? 17.446 10.322 18.511 1.00 85.03 ? 158 ARG B NH2 1 ATOM 5518 N N . LEU B 1 159 ? 22.482 10.979 24.046 1.00 39.36 ? 159 LEU B N 1 ATOM 5519 C CA . LEU B 1 159 ? 22.929 9.858 24.867 1.00 38.97 ? 159 LEU B CA 1 ATOM 5520 C C . LEU B 1 159 ? 22.028 8.622 24.744 1.00 43.54 ? 159 LEU B C 1 ATOM 5521 O O . LEU B 1 159 ? 20.804 8.752 24.592 1.00 43.95 ? 159 LEU B O 1 ATOM 5522 C CB . LEU B 1 159 ? 23.038 10.318 26.322 1.00 39.11 ? 159 LEU B CB 1 ATOM 5523 C CG . LEU B 1 159 ? 24.392 10.861 26.854 1.00 44.04 ? 159 LEU B CG 1 ATOM 5524 C CD1 . LEU B 1 159 ? 25.250 11.523 25.792 1.00 43.90 ? 159 LEU B CD1 1 ATOM 5525 C CD2 . LEU B 1 159 ? 24.174 11.825 27.997 1.00 47.10 ? 159 LEU B CD2 1 ATOM 5526 N N . ILE B 1 160 ? 22.651 7.419 24.777 1.00 38.68 ? 160 ILE B N 1 ATOM 5527 C CA . ILE B 1 160 ? 21.974 6.120 24.737 1.00 37.21 ? 160 ILE B CA 1 ATOM 5528 C C . ILE B 1 160 ? 22.355 5.353 26.009 1.00 43.49 ? 160 ILE B C 1 ATOM 5529 O O . ILE B 1 160 ? 23.543 5.195 26.320 1.00 43.80 ? 160 ILE B O 1 ATOM 5530 C CB . ILE B 1 160 ? 22.138 5.328 23.392 1.00 39.10 ? 160 ILE B CB 1 ATOM 5531 C CG1 . ILE B 1 160 ? 21.253 4.046 23.327 1.00 38.66 ? 160 ILE B CG1 1 ATOM 5532 C CG2 . ILE B 1 160 ? 23.579 5.016 23.036 1.00 39.25 ? 160 ILE B CG2 1 ATOM 5533 C CD1 . ILE B 1 160 ? 19.816 4.240 22.826 1.00 41.53 ? 160 ILE B CD1 1 ATOM 5534 N N . VAL B 1 161 ? 21.330 4.988 26.799 1.00 40.29 ? 161 VAL B N 1 ATOM 5535 C CA . VAL B 1 161 ? 21.486 4.261 28.058 1.00 39.74 ? 161 VAL B CA 1 ATOM 5536 C C . VAL B 1 161 ? 20.768 2.931 27.863 1.00 43.63 ? 161 VAL B C 1 ATOM 5537 O O . VAL B 1 161 ? 19.550 2.914 27.676 1.00 43.48 ? 161 VAL B O 1 ATOM 5538 C CB . VAL B 1 161 ? 20.979 5.057 29.301 1.00 43.37 ? 161 VAL B CB 1 ATOM 5539 C CG1 . VAL B 1 161 ? 21.096 4.232 30.578 1.00 42.69 ? 161 VAL B CG1 1 ATOM 5540 C CG2 . VAL B 1 161 ? 21.713 6.386 29.459 1.00 43.18 ? 161 VAL B CG2 1 ATOM 5541 N N . PHE B 1 162 ? 21.530 1.818 27.895 1.00 38.68 ? 162 PHE B N 1 ATOM 5542 C CA . PHE B 1 162 ? 20.972 0.499 27.664 1.00 37.10 ? 162 PHE B CA 1 ATOM 5543 C C . PHE B 1 162 ? 21.469 -0.582 28.617 1.00 42.87 ? 162 PHE B C 1 ATOM 5544 O O . PHE B 1 162 ? 22.650 -0.589 28.957 1.00 42.71 ? 162 PHE B O 1 ATOM 5545 C CB . PHE B 1 162 ? 21.226 0.077 26.209 1.00 37.64 ? 162 PHE B CB 1 ATOM 5546 C CG . PHE B 1 162 ? 22.670 0.088 25.765 1.00 37.36 ? 162 PHE B CG 1 ATOM 5547 C CD1 . PHE B 1 162 ? 23.255 1.249 25.268 1.00 38.85 ? 162 PHE B CD1 1 ATOM 5548 C CD2 . PHE B 1 162 ? 23.424 -1.083 25.767 1.00 37.49 ? 162 PHE B CD2 1 ATOM 5549 C CE1 . PHE B 1 162 ? 24.572 1.242 24.806 1.00 39.22 ? 162 PHE B CE1 1 ATOM 5550 C CE2 . PHE B 1 162 ? 24.744 -1.087 25.316 1.00 38.76 ? 162 PHE B CE2 1 ATOM 5551 C CZ . PHE B 1 162 ? 25.303 0.068 24.825 1.00 37.12 ? 162 PHE B CZ 1 ATOM 5552 N N . PRO B 1 163 ? 20.604 -1.553 29.009 1.00 40.54 ? 163 PRO B N 1 ATOM 5553 C CA . PRO B 1 163 ? 21.091 -2.657 29.834 1.00 40.44 ? 163 PRO B CA 1 ATOM 5554 C C . PRO B 1 163 ? 21.751 -3.712 28.923 1.00 45.58 ? 163 PRO B C 1 ATOM 5555 O O . PRO B 1 163 ? 21.674 -3.595 27.689 1.00 46.42 ? 163 PRO B O 1 ATOM 5556 C CB . PRO B 1 163 ? 19.809 -3.183 30.480 1.00 41.90 ? 163 PRO B CB 1 ATOM 5557 C CG . PRO B 1 163 ? 18.766 -2.947 29.468 1.00 46.44 ? 163 PRO B CG 1 ATOM 5558 C CD . PRO B 1 163 ? 19.171 -1.734 28.676 1.00 42.32 ? 163 PRO B CD 1 ATOM 5559 N N . ASP B 1 164 ? 22.368 -4.752 29.525 1.00 40.13 ? 164 ASP B N 1 ATOM 5560 C CA . ASP B 1 164 ? 23.012 -5.841 28.791 1.00 38.75 ? 164 ASP B CA 1 ATOM 5561 C C . ASP B 1 164 ? 22.026 -6.585 27.903 1.00 42.87 ? 164 ASP B C 1 ATOM 5562 O O . ASP B 1 164 ? 20.858 -6.728 28.265 1.00 44.40 ? 164 ASP B O 1 ATOM 5563 C CB . ASP B 1 164 ? 23.660 -6.831 29.765 1.00 39.89 ? 164 ASP B CB 1 ATOM 5564 C CG . ASP B 1 164 ? 24.552 -7.825 29.079 1.00 42.17 ? 164 ASP B CG 1 ATOM 5565 O OD1 . ASP B 1 164 ? 25.640 -7.423 28.633 1.00 45.82 ? 164 ASP B OD1 1 ATOM 5566 O OD2 . ASP B 1 164 ? 24.119 -8.979 28.896 1.00 40.54 ? 164 ASP B OD2 1 ATOM 5567 N N . LEU B 1 165 ? 22.503 -7.075 26.758 1.00 37.61 ? 165 LEU B N 1 ATOM 5568 C CA . LEU B 1 165 ? 21.729 -7.836 25.784 1.00 37.55 ? 165 LEU B CA 1 ATOM 5569 C C . LEU B 1 165 ? 20.874 -8.939 26.422 1.00 42.34 ? 165 LEU B C 1 ATOM 5570 O O . LEU B 1 165 ? 19.725 -9.140 26.005 1.00 43.28 ? 165 LEU B O 1 ATOM 5571 C CB . LEU B 1 165 ? 22.689 -8.398 24.719 1.00 37.68 ? 165 LEU B CB 1 ATOM 5572 C CG . LEU B 1 165 ? 22.207 -9.461 23.723 1.00 40.75 ? 165 LEU B CG 1 ATOM 5573 C CD1 . LEU B 1 165 ? 21.185 -8.899 22.756 1.00 40.08 ? 165 LEU B CD1 1 ATOM 5574 C CD2 . LEU B 1 165 ? 23.379 -10.006 22.962 1.00 41.82 ? 165 LEU B CD2 1 ATOM 5575 N N . GLY B 1 166 ? 21.428 -9.608 27.437 1.00 37.91 ? 166 GLY B N 1 ATOM 5576 C CA . GLY B 1 166 ? 20.738 -10.663 28.176 1.00 37.68 ? 166 GLY B CA 1 ATOM 5577 C C . GLY B 1 166 ? 19.474 -10.176 28.854 1.00 40.79 ? 166 GLY B C 1 ATOM 5578 O O . GLY B 1 166 ? 18.454 -10.864 28.795 1.00 40.63 ? 166 GLY B O 1 ATOM 5579 N N . VAL B 1 167 ? 19.539 -8.965 29.478 1.00 36.44 ? 167 VAL B N 1 ATOM 5580 C CA . VAL B 1 167 ? 18.433 -8.266 30.163 1.00 36.11 ? 167 VAL B CA 1 ATOM 5581 C C . VAL B 1 167 ? 17.395 -7.859 29.121 1.00 40.70 ? 167 VAL B C 1 ATOM 5582 O O . VAL B 1 167 ? 16.188 -7.907 29.392 1.00 40.35 ? 167 VAL B O 1 ATOM 5583 C CB . VAL B 1 167 ? 18.939 -7.018 30.958 1.00 39.47 ? 167 VAL B CB 1 ATOM 5584 C CG1 . VAL B 1 167 ? 17.793 -6.258 31.617 1.00 38.54 ? 167 VAL B CG1 1 ATOM 5585 C CG2 . VAL B 1 167 ? 19.979 -7.410 32.002 1.00 39.64 ? 167 VAL B CG2 1 ATOM 5586 N N . ARG B 1 168 ? 17.882 -7.443 27.934 1.00 37.06 ? 168 ARG B N 1 ATOM 5587 C CA . ARG B 1 168 ? 17.058 -6.972 26.821 1.00 36.56 ? 168 ARG B CA 1 ATOM 5588 C C . ARG B 1 168 ? 16.151 -8.067 26.253 1.00 38.15 ? 168 ARG B C 1 ATOM 5589 O O . ARG B 1 168 ? 15.023 -7.765 25.874 1.00 37.54 ? 168 ARG B O 1 ATOM 5590 C CB . ARG B 1 168 ? 17.923 -6.317 25.731 1.00 37.25 ? 168 ARG B CB 1 ATOM 5591 C CG . ARG B 1 168 ? 18.804 -5.160 26.228 1.00 42.28 ? 168 ARG B CG 1 ATOM 5592 C CD . ARG B 1 168 ? 19.167 -4.171 25.130 1.00 42.23 ? 168 ARG B CD 1 ATOM 5593 N NE . ARG B 1 168 ? 19.941 -4.772 24.035 1.00 36.31 ? 168 ARG B NE 1 ATOM 5594 C CZ . ARG B 1 168 ? 21.270 -4.802 23.979 1.00 49.98 ? 168 ARG B CZ 1 ATOM 5595 N NH1 . ARG B 1 168 ? 21.997 -4.298 24.970 1.00 43.33 ? 168 ARG B NH1 1 ATOM 5596 N NH2 . ARG B 1 168 ? 21.881 -5.374 22.951 1.00 32.96 ? 168 ARG B NH2 1 ATOM 5597 N N . VAL B 1 169 ? 16.627 -9.334 26.225 1.00 32.98 ? 169 VAL B N 1 ATOM 5598 C CA . VAL B 1 169 ? 15.841 -10.485 25.752 1.00 32.88 ? 169 VAL B CA 1 ATOM 5599 C C . VAL B 1 169 ? 14.754 -10.780 26.826 1.00 38.71 ? 169 VAL B C 1 ATOM 5600 O O . VAL B 1 169 ? 13.632 -11.206 26.496 1.00 39.39 ? 169 VAL B O 1 ATOM 5601 C CB . VAL B 1 169 ? 16.742 -11.724 25.409 1.00 36.81 ? 169 VAL B CB 1 ATOM 5602 C CG1 . VAL B 1 169 ? 15.920 -12.922 24.934 1.00 36.42 ? 169 VAL B CG1 1 ATOM 5603 C CG2 . VAL B 1 169 ? 17.806 -11.380 24.361 1.00 36.52 ? 169 VAL B CG2 1 ATOM 5604 N N . CYS B 1 170 ? 15.076 -10.481 28.107 1.00 34.57 ? 170 CYS B N 1 ATOM 5605 C CA . CYS B 1 170 ? 14.153 -10.650 29.226 1.00 33.96 ? 170 CYS B CA 1 ATOM 5606 C C . CYS B 1 170 ? 13.040 -9.631 29.194 1.00 36.80 ? 170 CYS B C 1 ATOM 5607 O O . CYS B 1 170 ? 11.900 -9.983 29.498 1.00 36.96 ? 170 CYS B O 1 ATOM 5608 C CB . CYS B 1 170 ? 14.889 -10.655 30.561 1.00 34.36 ? 170 CYS B CB 1 ATOM 5609 S SG . CYS B 1 170 ? 15.890 -12.138 30.838 1.00 38.27 ? 170 CYS B SG 1 ATOM 5610 N N . GLU B 1 171 ? 13.366 -8.370 28.805 1.00 31.57 ? 171 GLU B N 1 ATOM 5611 C CA . GLU B 1 171 ? 12.408 -7.272 28.639 1.00 29.93 ? 171 GLU B CA 1 ATOM 5612 C C . GLU B 1 171 ? 11.405 -7.696 27.569 1.00 34.46 ? 171 GLU B C 1 ATOM 5613 O O . GLU B 1 171 ? 10.216 -7.482 27.745 1.00 35.30 ? 171 GLU B O 1 ATOM 5614 C CB . GLU B 1 171 ? 13.114 -5.999 28.161 1.00 30.92 ? 171 GLU B CB 1 ATOM 5615 C CG . GLU B 1 171 ? 13.940 -5.262 29.191 1.00 40.20 ? 171 GLU B CG 1 ATOM 5616 C CD . GLU B 1 171 ? 14.378 -3.903 28.681 1.00 52.96 ? 171 GLU B CD 1 ATOM 5617 O OE1 . GLU B 1 171 ? 13.553 -2.962 28.729 1.00 38.32 ? 171 GLU B OE1 1 ATOM 5618 O OE2 . GLU B 1 171 ? 15.511 -3.797 28.156 1.00 45.50 ? 171 GLU B OE2 1 ATOM 5619 N N . LYS B 1 172 ? 11.877 -8.315 26.458 1.00 30.92 ? 172 LYS B N 1 ATOM 5620 C CA . LYS B 1 172 ? 11.033 -8.827 25.374 1.00 29.84 ? 172 LYS B CA 1 ATOM 5621 C C . LYS B 1 172 ? 10.073 -9.883 25.911 1.00 34.20 ? 172 LYS B C 1 ATOM 5622 O O . LYS B 1 172 ? 8.881 -9.837 25.586 1.00 35.27 ? 172 LYS B O 1 ATOM 5623 C CB . LYS B 1 172 ? 11.873 -9.389 24.223 1.00 30.73 ? 172 LYS B CB 1 ATOM 5624 C CG . LYS B 1 172 ? 12.726 -8.347 23.538 1.00 37.71 ? 172 LYS B CG 1 ATOM 5625 C CD . LYS B 1 172 ? 13.128 -8.777 22.128 1.00 41.72 ? 172 LYS B CD 1 ATOM 5626 C CE . LYS B 1 172 ? 14.519 -8.339 21.702 1.00 46.29 ? 172 LYS B CE 1 ATOM 5627 N NZ . LYS B 1 172 ? 15.008 -7.112 22.409 1.00 43.01 ? 172 LYS B NZ 1 ATOM 5628 N N A MET B 1 173 ? 10.573 -10.803 26.754 0.50 29.92 ? 173 MET B N 1 ATOM 5629 N N B MET B 1 173 ? 10.578 -10.811 26.753 0.50 30.14 ? 173 MET B N 1 ATOM 5630 C CA A MET B 1 173 ? 9.742 -11.852 27.344 0.50 29.68 ? 173 MET B CA 1 ATOM 5631 C CA B MET B 1 173 ? 9.760 -11.867 27.356 0.50 30.00 ? 173 MET B CA 1 ATOM 5632 C C A MET B 1 173 ? 8.601 -11.273 28.182 0.50 36.12 ? 173 MET B C 1 ATOM 5633 C C B MET B 1 173 ? 8.607 -11.275 28.177 0.50 36.25 ? 173 MET B C 1 ATOM 5634 O O A MET B 1 173 ? 7.446 -11.652 27.982 0.50 37.41 ? 173 MET B O 1 ATOM 5635 O O B MET B 1 173 ? 7.453 -11.649 27.964 0.50 37.54 ? 173 MET B O 1 ATOM 5636 C CB A MET B 1 173 ? 10.583 -12.824 28.179 0.50 31.52 ? 173 MET B CB 1 ATOM 5637 C CB B MET B 1 173 ? 10.608 -12.792 28.245 0.50 31.95 ? 173 MET B CB 1 ATOM 5638 C CG A MET B 1 173 ? 11.384 -13.794 27.343 0.50 34.46 ? 173 MET B CG 1 ATOM 5639 C CG B MET B 1 173 ? 11.456 -13.784 27.484 0.50 35.03 ? 173 MET B CG 1 ATOM 5640 S SD A MET B 1 173 ? 12.297 -15.053 28.258 0.50 37.86 ? 173 MET B SD 1 ATOM 5641 S SD B MET B 1 173 ? 13.034 -14.101 28.317 0.50 38.61 ? 173 MET B SD 1 ATOM 5642 C CE A MET B 1 173 ? 13.326 -14.123 29.168 0.50 34.26 ? 173 MET B CE 1 ATOM 5643 C CE B MET B 1 173 ? 12.568 -15.341 29.448 0.50 35.18 ? 173 MET B CE 1 ATOM 5644 N N . ALA B 1 174 ? 8.918 -10.329 29.083 1.00 32.24 ? 174 ALA B N 1 ATOM 5645 C CA . ALA B 1 174 ? 7.959 -9.686 29.980 1.00 31.29 ? 174 ALA B CA 1 ATOM 5646 C C . ALA B 1 174 ? 7.032 -8.661 29.349 1.00 36.32 ? 174 ALA B C 1 ATOM 5647 O O . ALA B 1 174 ? 5.848 -8.586 29.722 1.00 35.27 ? 174 ALA B O 1 ATOM 5648 C CB . ALA B 1 174 ? 8.703 -9.041 31.139 1.00 31.44 ? 174 ALA B CB 1 ATOM 5649 N N . LEU B 1 175 ? 7.573 -7.832 28.433 1.00 33.89 ? 175 LEU B N 1 ATOM 5650 C CA . LEU B 1 175 ? 6.852 -6.668 27.917 1.00 33.00 ? 175 LEU B CA 1 ATOM 5651 C C . LEU B 1 175 ? 6.674 -6.533 26.391 1.00 36.17 ? 175 LEU B C 1 ATOM 5652 O O . LEU B 1 175 ? 5.975 -5.599 25.979 1.00 34.63 ? 175 LEU B O 1 ATOM 5653 C CB . LEU B 1 175 ? 7.545 -5.405 28.468 1.00 32.11 ? 175 LEU B CB 1 ATOM 5654 C CG . LEU B 1 175 ? 7.294 -5.170 29.947 1.00 34.89 ? 175 LEU B CG 1 ATOM 5655 C CD1 . LEU B 1 175 ? 8.496 -4.572 30.622 1.00 33.74 ? 175 LEU B CD1 1 ATOM 5656 C CD2 . LEU B 1 175 ? 6.005 -4.388 30.172 1.00 36.67 ? 175 LEU B CD2 1 ATOM 5657 N N . TYR B 1 176 ? 7.229 -7.438 25.561 1.00 33.24 ? 176 TYR B N 1 ATOM 5658 C CA . TYR B 1 176 ? 7.027 -7.267 24.124 1.00 33.69 ? 176 TYR B CA 1 ATOM 5659 C C . TYR B 1 176 ? 5.546 -7.203 23.742 1.00 40.39 ? 176 TYR B C 1 ATOM 5660 O O . TYR B 1 176 ? 5.154 -6.244 23.095 1.00 39.30 ? 176 TYR B O 1 ATOM 5661 C CB . TYR B 1 176 ? 7.783 -8.290 23.267 1.00 34.65 ? 176 TYR B CB 1 ATOM 5662 C CG . TYR B 1 176 ? 7.619 -8.026 21.785 1.00 36.49 ? 176 TYR B CG 1 ATOM 5663 C CD1 . TYR B 1 176 ? 8.453 -7.130 21.120 1.00 38.77 ? 176 TYR B CD1 1 ATOM 5664 C CD2 . TYR B 1 176 ? 6.584 -8.615 21.060 1.00 36.65 ? 176 TYR B CD2 1 ATOM 5665 C CE1 . TYR B 1 176 ? 8.285 -6.857 19.765 1.00 39.58 ? 176 TYR B CE1 1 ATOM 5666 C CE2 . TYR B 1 176 ? 6.390 -8.326 19.714 1.00 37.48 ? 176 TYR B CE2 1 ATOM 5667 C CZ . TYR B 1 176 ? 7.249 -7.454 19.070 1.00 46.74 ? 176 TYR B CZ 1 ATOM 5668 O OH . TYR B 1 176 ? 7.075 -7.194 17.740 1.00 51.13 ? 176 TYR B OH 1 ATOM 5669 N N . ASP B 1 177 ? 4.722 -8.193 24.158 1.00 40.21 ? 177 ASP B N 1 ATOM 5670 C CA . ASP B 1 177 ? 3.276 -8.207 23.858 1.00 40.35 ? 177 ASP B CA 1 ATOM 5671 C C . ASP B 1 177 ? 2.532 -7.024 24.492 1.00 44.07 ? 177 ASP B C 1 ATOM 5672 O O . ASP B 1 177 ? 1.522 -6.595 23.940 1.00 44.78 ? 177 ASP B O 1 ATOM 5673 C CB . ASP B 1 177 ? 2.625 -9.543 24.260 1.00 42.38 ? 177 ASP B CB 1 ATOM 5674 C CG . ASP B 1 177 ? 1.331 -9.853 23.518 1.00 56.37 ? 177 ASP B CG 1 ATOM 5675 O OD1 . ASP B 1 177 ? 1.313 -9.730 22.270 1.00 58.77 ? 177 ASP B OD1 1 ATOM 5676 O OD2 . ASP B 1 177 ? 0.356 -10.287 24.175 1.00 60.85 ? 177 ASP B OD2 1 ATOM 5677 N N . VAL B 1 178 ? 3.042 -6.490 25.630 1.00 39.19 ? 178 VAL B N 1 ATOM 5678 C CA . VAL B 1 178 ? 2.472 -5.334 26.333 1.00 38.34 ? 178 VAL B CA 1 ATOM 5679 C C . VAL B 1 178 ? 2.633 -4.055 25.491 1.00 40.73 ? 178 VAL B C 1 ATOM 5680 O O . VAL B 1 178 ? 1.627 -3.477 25.087 1.00 40.07 ? 178 VAL B O 1 ATOM 5681 C CB . VAL B 1 178 ? 3.023 -5.161 27.780 1.00 41.71 ? 178 VAL B CB 1 ATOM 5682 C CG1 . VAL B 1 178 ? 2.571 -3.834 28.396 1.00 41.08 ? 178 VAL B CG1 1 ATOM 5683 C CG2 . VAL B 1 178 ? 2.614 -6.326 28.664 1.00 41.30 ? 178 VAL B CG2 1 ATOM 5684 N N . VAL B 1 179 ? 3.892 -3.629 25.219 1.00 36.49 ? 179 VAL B N 1 ATOM 5685 C CA . VAL B 1 179 ? 4.221 -2.419 24.440 1.00 35.90 ? 179 VAL B CA 1 ATOM 5686 C C . VAL B 1 179 ? 3.583 -2.462 23.035 1.00 40.97 ? 179 VAL B C 1 ATOM 5687 O O . VAL B 1 179 ? 3.379 -1.423 22.404 1.00 42.19 ? 179 VAL B O 1 ATOM 5688 C CB . VAL B 1 179 ? 5.746 -2.106 24.398 1.00 39.03 ? 179 VAL B CB 1 ATOM 5689 C CG1 . VAL B 1 179 ? 6.344 -2.038 25.811 1.00 38.37 ? 179 VAL B CG1 1 ATOM 5690 C CG2 . VAL B 1 179 ? 6.518 -3.094 23.516 1.00 38.70 ? 179 VAL B CG2 1 ATOM 5691 N N . SER B 1 180 ? 3.226 -3.673 22.585 1.00 36.21 ? 180 SER B N 1 ATOM 5692 C CA . SER B 1 180 ? 2.603 -3.913 21.299 1.00 35.41 ? 180 SER B CA 1 ATOM 5693 C C . SER B 1 180 ? 1.082 -3.710 21.312 1.00 40.90 ? 180 SER B C 1 ATOM 5694 O O . SER B 1 180 ? 0.555 -3.134 20.358 1.00 41.34 ? 180 SER B O 1 ATOM 5695 C CB . SER B 1 180 ? 2.927 -5.320 20.813 1.00 35.74 ? 180 SER B CB 1 ATOM 5696 O OG . SER B 1 180 ? 4.324 -5.509 20.698 1.00 39.21 ? 180 SER B OG 1 ATOM 5697 N N A THR B 1 181 ? 0.390 -4.181 22.375 0.50 37.48 ? 181 THR B N 1 ATOM 5698 N N B THR B 1 181 ? 0.388 -4.183 22.371 0.50 36.74 ? 181 THR B N 1 ATOM 5699 C CA A THR B 1 181 ? -1.071 -4.143 22.488 0.50 37.53 ? 181 THR B CA 1 ATOM 5700 C CA B THR B 1 181 ? -1.073 -4.144 22.492 0.50 36.44 ? 181 THR B CA 1 ATOM 5701 C C A THR B 1 181 ? -1.647 -3.011 23.351 0.50 41.28 ? 181 THR B C 1 ATOM 5702 C C B THR B 1 181 ? -1.628 -2.982 23.333 0.50 40.79 ? 181 THR B C 1 ATOM 5703 O O A THR B 1 181 ? -2.693 -2.475 22.991 0.50 41.53 ? 181 THR B O 1 ATOM 5704 O O B THR B 1 181 ? -2.640 -2.402 22.942 0.50 41.04 ? 181 THR B O 1 ATOM 5705 C CB A THR B 1 181 ? -1.608 -5.497 22.976 0.50 49.88 ? 181 THR B CB 1 ATOM 5706 C CB B THR B 1 181 ? -1.593 -5.495 23.029 0.50 43.79 ? 181 THR B CB 1 ATOM 5707 O OG1 A THR B 1 181 ? -1.050 -5.805 24.255 0.50 51.76 ? 181 THR B OG1 1 ATOM 5708 O OG1 B THR B 1 181 ? -0.796 -6.560 22.509 0.50 42.93 ? 181 THR B OG1 1 ATOM 5709 C CG2 A THR B 1 181 ? -1.328 -6.630 21.996 0.50 49.51 ? 181 THR B CG2 1 ATOM 5710 C CG2 B THR B 1 181 ? -3.077 -5.738 22.714 0.50 40.95 ? 181 THR B CG2 1 ATOM 5711 N N . LEU B 1 182 ? -1.012 -2.682 24.494 1.00 37.12 ? 182 LEU B N 1 ATOM 5712 C CA . LEU B 1 182 ? -1.480 -1.650 25.434 1.00 36.60 ? 182 LEU B CA 1 ATOM 5713 C C . LEU B 1 182 ? -1.654 -0.211 24.883 1.00 43.58 ? 182 LEU B C 1 ATOM 5714 O O . LEU B 1 182 ? -2.699 0.377 25.197 1.00 44.77 ? 182 LEU B O 1 ATOM 5715 C CB . LEU B 1 182 ? -0.592 -1.602 26.677 1.00 36.07 ? 182 LEU B CB 1 ATOM 5716 C CG . LEU B 1 182 ? -1.046 -0.713 27.834 1.00 39.28 ? 182 LEU B CG 1 ATOM 5717 C CD1 . LEU B 1 182 ? -1.925 -1.462 28.749 1.00 39.09 ? 182 LEU B CD1 1 ATOM 5718 C CD2 . LEU B 1 182 ? 0.132 -0.259 28.630 1.00 42.36 ? 182 LEU B CD2 1 ATOM 5719 N N . PRO B 1 183 ? -0.693 0.420 24.146 1.00 39.95 ? 183 PRO B N 1 ATOM 5720 C CA . PRO B 1 183 ? -0.902 1.818 23.733 1.00 39.06 ? 183 PRO B CA 1 ATOM 5721 C C . PRO B 1 183 ? -2.158 2.060 22.900 1.00 42.67 ? 183 PRO B C 1 ATOM 5722 O O . PRO B 1 183 ? -2.802 3.090 23.079 1.00 41.12 ? 183 PRO B O 1 ATOM 5723 C CB . PRO B 1 183 ? 0.383 2.161 22.980 1.00 40.46 ? 183 PRO B CB 1 ATOM 5724 C CG . PRO B 1 183 ? 1.381 1.212 23.450 1.00 45.37 ? 183 PRO B CG 1 ATOM 5725 C CD . PRO B 1 183 ? 0.625 -0.060 23.681 1.00 41.55 ? 183 PRO B CD 1 ATOM 5726 N N . GLN B 1 184 ? -2.518 1.096 22.027 1.00 40.21 ? 184 GLN B N 1 ATOM 5727 C CA . GLN B 1 184 ? -3.697 1.166 21.172 1.00 40.22 ? 184 GLN B CA 1 ATOM 5728 C C . GLN B 1 184 ? -4.996 1.078 21.977 1.00 41.65 ? 184 GLN B C 1 ATOM 5729 O O . GLN B 1 184 ? -5.944 1.798 21.649 1.00 41.26 ? 184 GLN B O 1 ATOM 5730 C CB . GLN B 1 184 ? -3.658 0.078 20.090 1.00 42.21 ? 184 GLN B CB 1 ATOM 5731 C CG . GLN B 1 184 ? -4.243 0.517 18.747 1.00 71.62 ? 184 GLN B CG 1 ATOM 5732 C CD . GLN B 1 184 ? -5.764 0.626 18.733 1.00 97.67 ? 184 GLN B CD 1 ATOM 5733 O OE1 . GLN B 1 184 ? -6.499 -0.348 18.955 1.00 92.08 ? 184 GLN B OE1 1 ATOM 5734 N NE2 . GLN B 1 184 ? -6.272 1.828 18.490 1.00 92.94 ? 184 GLN B NE2 1 ATOM 5735 N N . VAL B 1 185 ? -5.051 0.214 23.009 1.00 35.74 ? 185 VAL B N 1 ATOM 5736 C CA . VAL B 1 185 ? -6.259 0.060 23.832 1.00 35.79 ? 185 VAL B CA 1 ATOM 5737 C C . VAL B 1 185 ? -6.520 1.328 24.675 1.00 43.73 ? 185 VAL B C 1 ATOM 5738 O O . VAL B 1 185 ? -7.609 1.911 24.616 1.00 44.27 ? 185 VAL B O 1 ATOM 5739 C CB . VAL B 1 185 ? -6.217 -1.218 24.715 1.00 38.41 ? 185 VAL B CB 1 ATOM 5740 C CG1 . VAL B 1 185 ? -7.479 -1.345 25.571 1.00 37.50 ? 185 VAL B CG1 1 ATOM 5741 C CG2 . VAL B 1 185 ? -6.000 -2.468 23.876 1.00 37.98 ? 185 VAL B CG2 1 ATOM 5742 N N . VAL B 1 186 ? -5.507 1.745 25.444 1.00 41.94 ? 186 VAL B N 1 ATOM 5743 C CA . VAL B 1 186 ? -5.557 2.898 26.344 1.00 42.27 ? 186 VAL B CA 1 ATOM 5744 C C . VAL B 1 186 ? -5.856 4.234 25.646 1.00 46.87 ? 186 VAL B C 1 ATOM 5745 O O . VAL B 1 186 ? -6.625 5.047 26.176 1.00 48.16 ? 186 VAL B O 1 ATOM 5746 C CB . VAL B 1 186 ? -4.239 2.970 27.134 1.00 45.82 ? 186 VAL B CB 1 ATOM 5747 C CG1 . VAL B 1 186 ? -4.069 4.319 27.816 1.00 45.54 ? 186 VAL B CG1 1 ATOM 5748 C CG2 . VAL B 1 186 ? -4.145 1.832 28.137 1.00 45.67 ? 186 VAL B CG2 1 ATOM 5749 N N . MET B 1 187 ? -5.232 4.455 24.473 1.00 40.71 ? 187 MET B N 1 ATOM 5750 C CA . MET B 1 187 ? -5.296 5.711 23.739 1.00 38.89 ? 187 MET B CA 1 ATOM 5751 C C . MET B 1 187 ? -6.134 5.707 22.467 1.00 40.95 ? 187 MET B C 1 ATOM 5752 O O . MET B 1 187 ? -6.466 6.780 21.978 1.00 40.58 ? 187 MET B O 1 ATOM 5753 C CB . MET B 1 187 ? -3.882 6.164 23.436 1.00 40.89 ? 187 MET B CB 1 ATOM 5754 C CG . MET B 1 187 ? -3.064 6.367 24.696 1.00 44.20 ? 187 MET B CG 1 ATOM 5755 S SD . MET B 1 187 ? -1.302 6.330 24.371 1.00 47.99 ? 187 MET B SD 1 ATOM 5756 C CE . MET B 1 187 ? -1.211 7.616 23.133 1.00 44.88 ? 187 MET B CE 1 ATOM 5757 N N . GLY B 1 188 ? -6.485 4.532 21.962 1.00 36.68 ? 188 GLY B N 1 ATOM 5758 C CA . GLY B 1 188 ? -7.300 4.400 20.767 1.00 37.20 ? 188 GLY B CA 1 ATOM 5759 C C . GLY B 1 188 ? -6.695 5.069 19.554 1.00 43.25 ? 188 GLY B C 1 ATOM 5760 O O . GLY B 1 188 ? -5.512 4.886 19.248 1.00 43.20 ? 188 GLY B O 1 ATOM 5761 N N . SER B 1 189 ? -7.501 5.899 18.900 1.00 40.00 ? 189 SER B N 1 ATOM 5762 C CA . SER B 1 189 ? -7.121 6.621 17.704 1.00 39.67 ? 189 SER B CA 1 ATOM 5763 C C . SER B 1 189 ? -5.989 7.632 17.945 1.00 44.13 ? 189 SER B C 1 ATOM 5764 O O . SER B 1 189 ? -5.298 8.002 16.993 1.00 44.56 ? 189 SER B O 1 ATOM 5765 C CB . SER B 1 189 ? -8.346 7.279 17.084 1.00 43.53 ? 189 SER B CB 1 ATOM 5766 O OG . SER B 1 189 ? -8.909 8.248 17.951 1.00 59.52 ? 189 SER B OG 1 ATOM 5767 N N . SER B 1 190 ? -5.770 8.045 19.221 1.00 39.45 ? 190 SER B N 1 ATOM 5768 C CA . SER B 1 190 ? -4.708 8.991 19.614 1.00 37.99 ? 190 SER B CA 1 ATOM 5769 C C . SER B 1 190 ? -3.329 8.371 19.467 1.00 41.52 ? 190 SER B C 1 ATOM 5770 O O . SER B 1 190 ? -2.362 9.096 19.239 1.00 41.25 ? 190 SER B O 1 ATOM 5771 C CB . SER B 1 190 ? -4.920 9.516 21.033 1.00 39.44 ? 190 SER B CB 1 ATOM 5772 O OG . SER B 1 190 ? -6.053 10.368 21.100 1.00 44.85 ? 190 SER B OG 1 ATOM 5773 N N . TYR B 1 191 ? -3.239 7.027 19.549 1.00 38.39 ? 191 TYR B N 1 ATOM 5774 C CA . TYR B 1 191 ? -1.977 6.316 19.361 1.00 38.10 ? 191 TYR B CA 1 ATOM 5775 C C . TYR B 1 191 ? -1.563 6.356 17.893 1.00 41.33 ? 191 TYR B C 1 ATOM 5776 O O . TYR B 1 191 ? -2.241 5.781 17.036 1.00 40.38 ? 191 TYR B O 1 ATOM 5777 C CB . TYR B 1 191 ? -2.041 4.877 19.869 1.00 39.03 ? 191 TYR B CB 1 ATOM 5778 C CG . TYR B 1 191 ? -0.671 4.242 19.888 1.00 41.32 ? 191 TYR B CG 1 ATOM 5779 C CD1 . TYR B 1 191 ? 0.397 4.857 20.538 1.00 43.50 ? 191 TYR B CD1 1 ATOM 5780 C CD2 . TYR B 1 191 ? -0.433 3.034 19.243 1.00 42.33 ? 191 TYR B CD2 1 ATOM 5781 C CE1 . TYR B 1 191 ? 1.668 4.288 20.540 1.00 44.08 ? 191 TYR B CE1 1 ATOM 5782 C CE2 . TYR B 1 191 ? 0.831 2.440 19.265 1.00 43.24 ? 191 TYR B CE2 1 ATOM 5783 C CZ . TYR B 1 191 ? 1.874 3.067 19.927 1.00 50.75 ? 191 TYR B CZ 1 ATOM 5784 O OH . TYR B 1 191 ? 3.126 2.509 19.946 1.00 55.19 ? 191 TYR B OH 1 ATOM 5785 N N . GLY B 1 192 ? -0.465 7.059 17.634 1.00 37.19 ? 192 GLY B N 1 ATOM 5786 C CA . GLY B 1 192 ? 0.044 7.313 16.293 1.00 36.59 ? 192 GLY B CA 1 ATOM 5787 C C . GLY B 1 192 ? 0.917 6.259 15.658 1.00 39.74 ? 192 GLY B C 1 ATOM 5788 O O . GLY B 1 192 ? 0.967 6.181 14.427 1.00 39.45 ? 192 GLY B O 1 ATOM 5789 N N . PHE B 1 193 ? 1.639 5.466 16.482 1.00 35.88 ? 193 PHE B N 1 ATOM 5790 C CA . PHE B 1 193 ? 2.552 4.427 15.998 1.00 35.34 ? 193 PHE B CA 1 ATOM 5791 C C . PHE B 1 193 ? 1.838 3.227 15.372 1.00 40.54 ? 193 PHE B C 1 ATOM 5792 O O . PHE B 1 193 ? 2.495 2.326 14.858 1.00 42.16 ? 193 PHE B O 1 ATOM 5793 C CB . PHE B 1 193 ? 3.520 3.986 17.098 1.00 37.24 ? 193 PHE B CB 1 ATOM 5794 C CG . PHE B 1 193 ? 4.628 4.948 17.479 1.00 39.46 ? 193 PHE B CG 1 ATOM 5795 C CD1 . PHE B 1 193 ? 5.406 5.569 16.501 1.00 42.32 ? 193 PHE B CD1 1 ATOM 5796 C CD2 . PHE B 1 193 ? 4.953 5.168 18.814 1.00 42.27 ? 193 PHE B CD2 1 ATOM 5797 C CE1 . PHE B 1 193 ? 6.448 6.433 16.856 1.00 43.02 ? 193 PHE B CE1 1 ATOM 5798 C CE2 . PHE B 1 193 ? 5.992 6.043 19.165 1.00 45.07 ? 193 PHE B CE2 1 ATOM 5799 C CZ . PHE B 1 193 ? 6.737 6.661 18.183 1.00 42.65 ? 193 PHE B CZ 1 ATOM 5800 N N . GLN B 1 194 ? 0.497 3.229 15.406 1.00 36.31 ? 194 GLN B N 1 ATOM 5801 C CA . GLN B 1 194 ? -0.377 2.216 14.834 1.00 35.69 ? 194 GLN B CA 1 ATOM 5802 C C . GLN B 1 194 ? -0.728 2.541 13.361 1.00 40.39 ? 194 GLN B C 1 ATOM 5803 O O . GLN B 1 194 ? -1.213 1.670 12.634 1.00 40.47 ? 194 GLN B O 1 ATOM 5804 C CB . GLN B 1 194 ? -1.663 2.139 15.668 1.00 36.53 ? 194 GLN B CB 1 ATOM 5805 C CG . GLN B 1 194 ? -2.759 3.126 15.254 1.00 26.54 ? 194 GLN B CG 1 ATOM 5806 C CD . GLN B 1 194 ? -3.988 2.907 16.082 1.00 37.12 ? 194 GLN B CD 1 ATOM 5807 O OE1 . GLN B 1 194 ? -4.817 2.026 15.800 1.00 25.46 ? 194 GLN B OE1 1 ATOM 5808 N NE2 . GLN B 1 194 ? -4.099 3.667 17.160 1.00 36.35 ? 194 GLN B NE2 1 ATOM 5809 N N . TYR B 1 195 ? -0.529 3.805 12.952 1.00 36.50 ? 195 TYR B N 1 ATOM 5810 C CA . TYR B 1 195 ? -0.866 4.288 11.619 1.00 35.68 ? 195 TYR B CA 1 ATOM 5811 C C . TYR B 1 195 ? 0.305 4.300 10.682 1.00 39.59 ? 195 TYR B C 1 ATOM 5812 O O . TYR B 1 195 ? 1.384 4.756 11.051 1.00 40.34 ? 195 TYR B O 1 ATOM 5813 C CB . TYR B 1 195 ? -1.376 5.742 11.696 1.00 36.11 ? 195 TYR B CB 1 ATOM 5814 C CG . TYR B 1 195 ? -2.593 5.969 12.560 1.00 35.80 ? 195 TYR B CG 1 ATOM 5815 C CD1 . TYR B 1 195 ? -3.813 5.384 12.240 1.00 37.47 ? 195 TYR B CD1 1 ATOM 5816 C CD2 . TYR B 1 195 ? -2.564 6.883 13.608 1.00 35.62 ? 195 TYR B CD2 1 ATOM 5817 C CE1 . TYR B 1 195 ? -4.951 5.625 12.999 1.00 38.15 ? 195 TYR B CE1 1 ATOM 5818 C CE2 . TYR B 1 195 ? -3.701 7.153 14.362 1.00 36.42 ? 195 TYR B CE2 1 ATOM 5819 C CZ . TYR B 1 195 ? -4.889 6.504 14.067 1.00 45.70 ? 195 TYR B CZ 1 ATOM 5820 O OH . TYR B 1 195 ? -6.022 6.717 14.811 1.00 46.57 ? 195 TYR B OH 1 ATOM 5821 N N . SER B 1 196 ? 0.053 3.955 9.422 1.00 35.66 ? 196 SER B N 1 ATOM 5822 C CA . SER B 1 196 ? 1.019 4.085 8.339 1.00 35.65 ? 196 SER B CA 1 ATOM 5823 C C . SER B 1 196 ? 1.137 5.610 8.044 1.00 38.78 ? 196 SER B C 1 ATOM 5824 O O . SER B 1 196 ? 0.283 6.353 8.545 1.00 37.42 ? 196 SER B O 1 ATOM 5825 C CB . SER B 1 196 ? 0.488 3.366 7.101 1.00 39.86 ? 196 SER B CB 1 ATOM 5826 O OG . SER B 1 196 ? -0.522 4.130 6.460 1.00 51.13 ? 196 SER B OG 1 ATOM 5827 N N . PRO B 1 197 ? 2.104 6.136 7.231 1.00 35.38 ? 197 PRO B N 1 ATOM 5828 C CA . PRO B 1 197 ? 2.083 7.591 6.952 1.00 34.68 ? 197 PRO B CA 1 ATOM 5829 C C . PRO B 1 197 ? 0.749 7.987 6.297 1.00 39.70 ? 197 PRO B C 1 ATOM 5830 O O . PRO B 1 197 ? 0.143 8.998 6.680 1.00 38.86 ? 197 PRO B O 1 ATOM 5831 C CB . PRO B 1 197 ? 3.284 7.799 6.022 1.00 35.77 ? 197 PRO B CB 1 ATOM 5832 C CG . PRO B 1 197 ? 4.133 6.601 6.199 1.00 40.29 ? 197 PRO B CG 1 ATOM 5833 C CD . PRO B 1 197 ? 3.216 5.472 6.514 1.00 36.25 ? 197 PRO B CD 1 ATOM 5834 N N . GLY B 1 198 ? 0.272 7.116 5.392 1.00 36.73 ? 198 GLY B N 1 ATOM 5835 C CA . GLY B 1 198 ? -0.977 7.261 4.669 1.00 36.54 ? 198 GLY B CA 1 ATOM 5836 C C . GLY B 1 198 ? -2.183 7.293 5.574 1.00 42.07 ? 198 GLY B C 1 ATOM 5837 O O . GLY B 1 198 ? -3.070 8.131 5.381 1.00 44.09 ? 198 GLY B O 1 ATOM 5838 N N . GLN B 1 199 ? -2.224 6.393 6.575 1.00 36.79 ? 199 GLN B N 1 ATOM 5839 C CA . GLN B 1 199 ? -3.326 6.324 7.541 1.00 36.56 ? 199 GLN B CA 1 ATOM 5840 C C . GLN B 1 199 ? -3.290 7.492 8.547 1.00 40.41 ? 199 GLN B C 1 ATOM 5841 O O . GLN B 1 199 ? -4.320 7.821 9.131 1.00 40.49 ? 199 GLN B O 1 ATOM 5842 C CB . GLN B 1 199 ? -3.292 4.985 8.301 1.00 38.00 ? 199 GLN B CB 1 ATOM 5843 C CG . GLN B 1 199 ? -3.739 3.772 7.491 1.00 38.74 ? 199 GLN B CG 1 ATOM 5844 C CD . GLN B 1 199 ? -3.539 2.454 8.199 1.00 44.17 ? 199 GLN B CD 1 ATOM 5845 O OE1 . GLN B 1 199 ? -2.842 2.337 9.212 1.00 37.95 ? 199 GLN B OE1 1 ATOM 5846 N NE2 . GLN B 1 199 ? -4.119 1.414 7.639 1.00 39.58 ? 199 GLN B NE2 1 ATOM 5847 N N . ARG B 1 200 ? -2.092 8.065 8.789 1.00 36.62 ? 200 ARG B N 1 ATOM 5848 C CA . ARG B 1 200 ? -1.860 9.180 9.703 1.00 36.04 ? 200 ARG B CA 1 ATOM 5849 C C . ARG B 1 200 ? -2.418 10.448 9.080 1.00 41.21 ? 200 ARG B C 1 ATOM 5850 O O . ARG B 1 200 ? -3.163 11.179 9.739 1.00 41.76 ? 200 ARG B O 1 ATOM 5851 C CB . ARG B 1 200 ? -0.358 9.338 10.003 1.00 34.51 ? 200 ARG B CB 1 ATOM 5852 C CG . ARG B 1 200 ? -0.037 10.532 10.896 1.00 38.31 ? 200 ARG B CG 1 ATOM 5853 C CD . ARG B 1 200 ? 1.430 10.667 11.236 1.00 43.68 ? 200 ARG B CD 1 ATOM 5854 N NE . ARG B 1 200 ? 1.651 11.782 12.158 1.00 51.08 ? 200 ARG B NE 1 ATOM 5855 C CZ . ARG B 1 200 ? 1.589 11.678 13.482 1.00 64.54 ? 200 ARG B CZ 1 ATOM 5856 N NH1 . ARG B 1 200 ? 1.320 10.508 14.052 1.00 50.96 ? 200 ARG B NH1 1 ATOM 5857 N NH2 . ARG B 1 200 ? 1.764 12.749 14.246 1.00 48.04 ? 200 ARG B NH2 1 ATOM 5858 N N . VAL B 1 201 ? -2.058 10.712 7.810 1.00 37.38 ? 201 VAL B N 1 ATOM 5859 C CA . VAL B 1 201 ? -2.555 11.872 7.074 1.00 36.65 ? 201 VAL B CA 1 ATOM 5860 C C . VAL B 1 201 ? -4.094 11.778 6.884 1.00 39.82 ? 201 VAL B C 1 ATOM 5861 O O . VAL B 1 201 ? -4.762 12.798 7.001 1.00 40.61 ? 201 VAL B O 1 ATOM 5862 C CB . VAL B 1 201 ? -1.765 12.129 5.769 1.00 40.10 ? 201 VAL B CB 1 ATOM 5863 C CG1 . VAL B 1 201 ? -2.011 11.037 4.727 1.00 39.55 ? 201 VAL B CG1 1 ATOM 5864 C CG2 . VAL B 1 201 ? -2.048 13.527 5.212 1.00 39.81 ? 201 VAL B CG2 1 ATOM 5865 N N . GLU B 1 202 ? -4.647 10.556 6.686 1.00 34.46 ? 202 GLU B N 1 ATOM 5866 C CA . GLU B 1 202 ? -6.085 10.320 6.588 1.00 33.91 ? 202 GLU B CA 1 ATOM 5867 C C . GLU B 1 202 ? -6.711 10.720 7.941 1.00 38.46 ? 202 GLU B C 1 ATOM 5868 O O . GLU B 1 202 ? -7.708 11.448 7.958 1.00 38.88 ? 202 GLU B O 1 ATOM 5869 C CB . GLU B 1 202 ? -6.365 8.832 6.269 1.00 35.25 ? 202 GLU B CB 1 ATOM 5870 C CG . GLU B 1 202 ? -7.836 8.432 6.206 1.00 43.85 ? 202 GLU B CG 1 ATOM 5871 C CD . GLU B 1 202 ? -8.519 8.567 4.855 1.00 67.89 ? 202 GLU B CD 1 ATOM 5872 O OE1 . GLU B 1 202 ? -8.178 7.783 3.941 1.00 72.64 ? 202 GLU B OE1 1 ATOM 5873 O OE2 . GLU B 1 202 ? -9.444 9.401 4.730 1.00 60.80 ? 202 GLU B OE2 1 ATOM 5874 N N . PHE B 1 203 ? -6.085 10.289 9.066 1.00 34.07 ? 203 PHE B N 1 ATOM 5875 C CA . PHE B 1 203 ? -6.548 10.581 10.421 1.00 33.83 ? 203 PHE B CA 1 ATOM 5876 C C . PHE B 1 203 ? -6.655 12.080 10.700 1.00 39.97 ? 203 PHE B C 1 ATOM 5877 O O . PHE B 1 203 ? -7.744 12.543 11.061 1.00 40.04 ? 203 PHE B O 1 ATOM 5878 C CB . PHE B 1 203 ? -5.670 9.885 11.475 1.00 35.00 ? 203 PHE B CB 1 ATOM 5879 C CG . PHE B 1 203 ? -6.093 10.165 12.897 1.00 35.94 ? 203 PHE B CG 1 ATOM 5880 C CD1 . PHE B 1 203 ? -7.126 9.438 13.490 1.00 38.39 ? 203 PHE B CD1 1 ATOM 5881 C CD2 . PHE B 1 203 ? -5.460 11.155 13.647 1.00 37.63 ? 203 PHE B CD2 1 ATOM 5882 C CE1 . PHE B 1 203 ? -7.521 9.697 14.805 1.00 39.39 ? 203 PHE B CE1 1 ATOM 5883 C CE2 . PHE B 1 203 ? -5.849 11.412 14.968 1.00 40.55 ? 203 PHE B CE2 1 ATOM 5884 C CZ . PHE B 1 203 ? -6.872 10.673 15.544 1.00 38.96 ? 203 PHE B CZ 1 ATOM 5885 N N . LEU B 1 204 ? -5.519 12.819 10.526 1.00 36.37 ? 204 LEU B N 1 ATOM 5886 C CA . LEU B 1 204 ? -5.365 14.258 10.730 1.00 36.35 ? 204 LEU B CA 1 ATOM 5887 C C . LEU B 1 204 ? -6.372 15.082 9.942 1.00 44.34 ? 204 LEU B C 1 ATOM 5888 O O . LEU B 1 204 ? -6.971 16.020 10.491 1.00 44.84 ? 204 LEU B O 1 ATOM 5889 C CB . LEU B 1 204 ? -3.957 14.683 10.321 1.00 36.14 ? 204 LEU B CB 1 ATOM 5890 C CG . LEU B 1 204 ? -2.817 14.301 11.256 1.00 39.58 ? 204 LEU B CG 1 ATOM 5891 C CD1 . LEU B 1 204 ? -1.493 14.401 10.537 1.00 38.71 ? 204 LEU B CD1 1 ATOM 5892 C CD2 . LEU B 1 204 ? -2.824 15.174 12.505 1.00 40.62 ? 204 LEU B CD2 1 ATOM 5893 N N . VAL B 1 205 ? -6.542 14.735 8.641 1.00 41.85 ? 205 VAL B N 1 ATOM 5894 C CA . VAL B 1 205 ? -7.474 15.386 7.711 1.00 40.81 ? 205 VAL B CA 1 ATOM 5895 C C . VAL B 1 205 ? -8.917 15.190 8.203 1.00 43.23 ? 205 VAL B C 1 ATOM 5896 O O . VAL B 1 205 ? -9.641 16.171 8.361 1.00 41.98 ? 205 VAL B O 1 ATOM 5897 C CB . VAL B 1 205 ? -7.235 14.933 6.243 1.00 43.77 ? 205 VAL B CB 1 ATOM 5898 C CG1 . VAL B 1 205 ? -8.324 15.444 5.308 1.00 43.68 ? 205 VAL B CG1 1 ATOM 5899 C CG2 . VAL B 1 205 ? -5.874 15.410 5.753 1.00 43.29 ? 205 VAL B CG2 1 ATOM 5900 N N . ASN B 1 206 ? -9.295 13.949 8.525 1.00 40.72 ? 206 ASN B N 1 ATOM 5901 C CA . ASN B 1 206 ? -10.632 13.654 9.041 1.00 41.33 ? 206 ASN B CA 1 ATOM 5902 C C . ASN B 1 206 ? -10.909 14.354 10.364 1.00 45.71 ? 206 ASN B C 1 ATOM 5903 O O . ASN B 1 206 ? -12.051 14.765 10.587 1.00 45.45 ? 206 ASN B O 1 ATOM 5904 C CB . ASN B 1 206 ? -10.883 12.162 9.141 1.00 42.18 ? 206 ASN B CB 1 ATOM 5905 C CG . ASN B 1 206 ? -10.940 11.487 7.803 1.00 65.89 ? 206 ASN B CG 1 ATOM 5906 O OD1 . ASN B 1 206 ? -11.531 11.990 6.844 1.00 66.05 ? 206 ASN B OD1 1 ATOM 5907 N ND2 . ASN B 1 206 ? -10.322 10.328 7.707 1.00 57.35 ? 206 ASN B ND2 1 ATOM 5908 N N . THR B 1 207 ? -9.856 14.536 11.204 1.00 41.76 ? 207 THR B N 1 ATOM 5909 C CA . THR B 1 207 ? -9.911 15.239 12.493 1.00 41.60 ? 207 THR B CA 1 ATOM 5910 C C . THR B 1 207 ? -10.148 16.742 12.263 1.00 45.86 ? 207 THR B C 1 ATOM 5911 O O . THR B 1 207 ? -11.012 17.337 12.906 1.00 45.72 ? 207 THR B O 1 ATOM 5912 C CB . THR B 1 207 ? -8.609 15.016 13.301 1.00 48.47 ? 207 THR B CB 1 ATOM 5913 O OG1 . THR B 1 207 ? -8.379 13.629 13.509 1.00 50.54 ? 207 THR B OG1 1 ATOM 5914 C CG2 . THR B 1 207 ? -8.629 15.708 14.632 1.00 45.65 ? 207 THR B CG2 1 ATOM 5915 N N . TRP B 1 208 ? -9.347 17.354 11.378 1.00 42.97 ? 208 TRP B N 1 ATOM 5916 C CA . TRP B 1 208 ? -9.432 18.779 11.049 1.00 43.09 ? 208 TRP B CA 1 ATOM 5917 C C . TRP B 1 208 ? -10.816 19.103 10.462 1.00 46.90 ? 208 TRP B C 1 ATOM 5918 O O . TRP B 1 208 ? -11.436 20.089 10.862 1.00 45.50 ? 208 TRP B O 1 ATOM 5919 C CB . TRP B 1 208 ? -8.299 19.154 10.079 1.00 41.38 ? 208 TRP B CB 1 ATOM 5920 C CG . TRP B 1 208 ? -8.030 20.620 9.988 1.00 41.74 ? 208 TRP B CG 1 ATOM 5921 C CD1 . TRP B 1 208 ? -8.525 21.489 9.062 1.00 44.61 ? 208 TRP B CD1 1 ATOM 5922 C CD2 . TRP B 1 208 ? -7.183 21.386 10.845 1.00 41.20 ? 208 TRP B CD2 1 ATOM 5923 N NE1 . TRP B 1 208 ? -8.030 22.752 9.286 1.00 43.84 ? 208 TRP B NE1 1 ATOM 5924 C CE2 . TRP B 1 208 ? -7.204 22.719 10.377 1.00 45.01 ? 208 TRP B CE2 1 ATOM 5925 C CE3 . TRP B 1 208 ? -6.415 21.081 11.975 1.00 42.25 ? 208 TRP B CE3 1 ATOM 5926 C CZ2 . TRP B 1 208 ? -6.500 23.747 11.010 1.00 44.21 ? 208 TRP B CZ2 1 ATOM 5927 C CZ3 . TRP B 1 208 ? -5.707 22.101 12.593 1.00 43.58 ? 208 TRP B CZ3 1 ATOM 5928 C CH2 . TRP B 1 208 ? -5.743 23.412 12.104 1.00 44.05 ? 208 TRP B CH2 1 ATOM 5929 N N . LYS B 1 209 ? -11.318 18.213 9.577 1.00 44.23 ? 209 LYS B N 1 ATOM 5930 C CA . LYS B 1 209 ? -12.632 18.309 8.931 1.00 44.61 ? 209 LYS B CA 1 ATOM 5931 C C . LYS B 1 209 ? -13.785 18.110 9.933 1.00 51.91 ? 209 LYS B C 1 ATOM 5932 O O . LYS B 1 209 ? -14.883 18.627 9.700 1.00 51.70 ? 209 LYS B O 1 ATOM 5933 C CB . LYS B 1 209 ? -12.746 17.305 7.761 1.00 45.25 ? 209 LYS B CB 1 ATOM 5934 C CG . LYS B 1 209 ? -11.990 17.730 6.503 1.00 45.93 ? 209 LYS B CG 1 ATOM 5935 C CD . LYS B 1 209 ? -11.986 16.647 5.438 1.00 56.75 ? 209 LYS B CD 1 ATOM 5936 C CE . LYS B 1 209 ? -11.514 17.172 4.100 1.00 68.91 ? 209 LYS B CE 1 ATOM 5937 N NZ . LYS B 1 209 ? -11.655 16.168 3.000 1.00 73.58 ? 209 LYS B NZ 1 ATOM 5938 N N . SER B 1 210 ? -13.529 17.381 11.050 1.00 49.72 ? 210 SER B N 1 ATOM 5939 C CA . SER B 1 210 ? -14.528 17.090 12.085 1.00 49.81 ? 210 SER B CA 1 ATOM 5940 C C . SER B 1 210 ? -14.828 18.288 12.990 1.00 56.29 ? 210 SER B C 1 ATOM 5941 O O . SER B 1 210 ? -15.866 18.306 13.662 1.00 56.55 ? 210 SER B O 1 ATOM 5942 C CB . SER B 1 210 ? -14.118 15.873 12.911 1.00 52.39 ? 210 SER B CB 1 ATOM 5943 O OG . SER B 1 210 ? -13.226 16.210 13.960 1.00 60.43 ? 210 SER B OG 1 ATOM 5944 N N . LYS B 1 211 ? -13.919 19.278 13.023 1.00 54.00 ? 211 LYS B N 1 ATOM 5945 C CA . LYS B 1 211 ? -14.084 20.476 13.852 1.00 54.02 ? 211 LYS B CA 1 ATOM 5946 C C . LYS B 1 211 ? -14.785 21.561 13.061 1.00 58.98 ? 211 LYS B C 1 ATOM 5947 O O . LYS B 1 211 ? -14.513 21.709 11.867 1.00 58.44 ? 211 LYS B O 1 ATOM 5948 C CB . LYS B 1 211 ? -12.723 20.998 14.381 1.00 56.57 ? 211 LYS B CB 1 ATOM 5949 C CG . LYS B 1 211 ? -11.774 19.952 15.005 1.00 67.87 ? 211 LYS B CG 1 ATOM 5950 C CD . LYS B 1 211 ? -12.381 19.167 16.163 1.00 67.01 ? 211 LYS B CD 1 ATOM 5951 C CE . LYS B 1 211 ? -11.640 17.884 16.408 1.00 66.42 ? 211 LYS B CE 1 ATOM 5952 N NZ . LYS B 1 211 ? -12.435 16.973 17.262 1.00 79.24 ? 211 LYS B NZ 1 ATOM 5953 N N . LYS B 1 212 ? -15.687 22.324 13.725 1.00 57.10 ? 212 LYS B N 1 ATOM 5954 C CA . LYS B 1 212 ? -16.429 23.448 13.130 1.00 57.56 ? 212 LYS B CA 1 ATOM 5955 C C . LYS B 1 212 ? -15.423 24.548 12.780 1.00 61.21 ? 212 LYS B C 1 ATOM 5956 O O . LYS B 1 212 ? -15.229 24.850 11.600 1.00 60.59 ? 212 LYS B O 1 ATOM 5957 C CB . LYS B 1 212 ? -17.522 23.960 14.086 1.00 60.91 ? 212 LYS B CB 1 ATOM 5958 C CG . LYS B 1 212 ? -18.659 22.966 14.298 1.00 83.12 ? 212 LYS B CG 1 ATOM 5959 C CD . LYS B 1 212 ? -19.372 23.194 15.618 1.00 96.37 ? 212 LYS B CD 1 ATOM 5960 C CE . LYS B 1 212 ? -20.453 22.163 15.849 1.00 112.96 ? 212 LYS B CE 1 ATOM 5961 N NZ . LYS B 1 212 ? -21.222 22.436 17.093 1.00 124.03 ? 212 LYS B NZ 1 ATOM 5962 N N . ASN B 1 213 ? -14.719 25.070 13.791 1.00 57.84 ? 213 ASN B N 1 ATOM 5963 C CA . ASN B 1 213 ? -13.650 26.042 13.587 1.00 57.87 ? 213 ASN B CA 1 ATOM 5964 C C . ASN B 1 213 ? -12.370 25.379 14.116 1.00 60.17 ? 213 ASN B C 1 ATOM 5965 O O . ASN B 1 213 ? -12.109 25.411 15.316 1.00 58.76 ? 213 ASN B O 1 ATOM 5966 C CB . ASN B 1 213 ? -13.949 27.381 14.266 1.00 63.04 ? 213 ASN B CB 1 ATOM 5967 C CG . ASN B 1 213 ? -15.283 27.995 13.894 1.00 100.59 ? 213 ASN B CG 1 ATOM 5968 O OD1 . ASN B 1 213 ? -15.811 27.841 12.785 1.00 99.23 ? 213 ASN B OD1 1 ATOM 5969 N ND2 . ASN B 1 213 ? -15.872 28.702 14.834 1.00 95.87 ? 213 ASN B ND2 1 ATOM 5970 N N . PRO B 1 214 ? -11.619 24.663 13.247 1.00 56.36 ? 214 PRO B N 1 ATOM 5971 C CA . PRO B 1 214 ? -10.442 23.929 13.730 1.00 55.35 ? 214 PRO B CA 1 ATOM 5972 C C . PRO B 1 214 ? -9.277 24.786 14.188 1.00 57.10 ? 214 PRO B C 1 ATOM 5973 O O . PRO B 1 214 ? -9.061 25.904 13.706 1.00 57.83 ? 214 PRO B O 1 ATOM 5974 C CB . PRO B 1 214 ? -10.067 23.046 12.548 1.00 57.29 ? 214 PRO B CB 1 ATOM 5975 C CG . PRO B 1 214 ? -10.538 23.808 11.367 1.00 62.46 ? 214 PRO B CG 1 ATOM 5976 C CD . PRO B 1 214 ? -11.821 24.450 11.801 1.00 58.18 ? 214 PRO B CD 1 ATOM 5977 N N . MET B 1 215 ? -8.546 24.238 15.159 1.00 49.83 ? 215 MET B N 1 ATOM 5978 C CA . MET B 1 215 ? -7.350 24.796 15.760 1.00 47.37 ? 215 MET B CA 1 ATOM 5979 C C . MET B 1 215 ? -6.481 23.615 16.087 1.00 49.53 ? 215 MET B C 1 ATOM 5980 O O . MET B 1 215 ? -6.969 22.604 16.591 1.00 48.70 ? 215 MET B O 1 ATOM 5981 C CB . MET B 1 215 ? -7.680 25.583 17.031 1.00 49.07 ? 215 MET B CB 1 ATOM 5982 C CG . MET B 1 215 ? -6.566 26.504 17.468 1.00 51.98 ? 215 MET B CG 1 ATOM 5983 S SD . MET B 1 215 ? -5.323 25.684 18.474 1.00 55.67 ? 215 MET B SD 1 ATOM 5984 C CE . MET B 1 215 ? -5.973 25.969 20.097 1.00 51.86 ? 215 MET B CE 1 ATOM 5985 N N . GLY B 1 216 ? -5.201 23.750 15.788 1.00 45.37 ? 216 GLY B N 1 ATOM 5986 C CA . GLY B 1 216 ? -4.222 22.710 16.050 1.00 44.75 ? 216 GLY B CA 1 ATOM 5987 C C . GLY B 1 216 ? -2.918 23.276 16.550 1.00 47.97 ? 216 GLY B C 1 ATOM 5988 O O . GLY B 1 216 ? -2.577 24.419 16.246 1.00 48.72 ? 216 GLY B O 1 ATOM 5989 N N . PHE B 1 217 ? -2.195 22.488 17.340 1.00 42.51 ? 217 PHE B N 1 ATOM 5990 C CA . PHE B 1 217 ? -0.882 22.854 17.855 1.00 41.75 ? 217 PHE B CA 1 ATOM 5991 C C . PHE B 1 217 ? -0.081 21.589 18.095 1.00 45.03 ? 217 PHE B C 1 ATOM 5992 O O . PHE B 1 217 ? -0.644 20.493 18.109 1.00 46.53 ? 217 PHE B O 1 ATOM 5993 C CB . PHE B 1 217 ? -0.986 23.704 19.131 1.00 43.49 ? 217 PHE B CB 1 ATOM 5994 C CG . PHE B 1 217 ? -1.546 23.006 20.344 1.00 44.90 ? 217 PHE B CG 1 ATOM 5995 C CD1 . PHE B 1 217 ? -2.915 22.862 20.511 1.00 48.18 ? 217 PHE B CD1 1 ATOM 5996 C CD2 . PHE B 1 217 ? -0.706 22.529 21.341 1.00 47.34 ? 217 PHE B CD2 1 ATOM 5997 C CE1 . PHE B 1 217 ? -3.436 22.234 21.642 1.00 49.24 ? 217 PHE B CE1 1 ATOM 5998 C CE2 . PHE B 1 217 ? -1.226 21.893 22.468 1.00 50.42 ? 217 PHE B CE2 1 ATOM 5999 C CZ . PHE B 1 217 ? -2.588 21.752 22.613 1.00 48.49 ? 217 PHE B CZ 1 ATOM 6000 N N . SER B 1 218 ? 1.223 21.733 18.253 1.00 39.63 ? 218 SER B N 1 ATOM 6001 C CA . SER B 1 218 ? 2.117 20.628 18.547 1.00 39.47 ? 218 SER B CA 1 ATOM 6002 C C . SER B 1 218 ? 2.848 20.969 19.839 1.00 43.81 ? 218 SER B C 1 ATOM 6003 O O . SER B 1 218 ? 2.953 22.142 20.177 1.00 42.96 ? 218 SER B O 1 ATOM 6004 C CB . SER B 1 218 ? 3.102 20.407 17.402 1.00 42.91 ? 218 SER B CB 1 ATOM 6005 O OG . SER B 1 218 ? 3.907 21.553 17.169 1.00 51.26 ? 218 SER B OG 1 ATOM 6006 N N . TYR B 1 219 ? 3.311 19.953 20.572 1.00 41.86 ? 219 TYR B N 1 ATOM 6007 C CA . TYR B 1 219 ? 4.039 20.161 21.808 1.00 43.10 ? 219 TYR B CA 1 ATOM 6008 C C . TYR B 1 219 ? 5.365 19.475 21.691 1.00 49.22 ? 219 TYR B C 1 ATOM 6009 O O . TYR B 1 219 ? 5.434 18.298 21.327 1.00 48.42 ? 219 TYR B O 1 ATOM 6010 C CB . TYR B 1 219 ? 3.253 19.671 23.041 1.00 45.30 ? 219 TYR B CB 1 ATOM 6011 C CG . TYR B 1 219 ? 3.719 20.279 24.349 1.00 48.68 ? 219 TYR B CG 1 ATOM 6012 C CD1 . TYR B 1 219 ? 3.351 21.575 24.710 1.00 51.01 ? 219 TYR B CD1 1 ATOM 6013 C CD2 . TYR B 1 219 ? 4.530 19.562 25.227 1.00 50.03 ? 219 TYR B CD2 1 ATOM 6014 C CE1 . TYR B 1 219 ? 3.786 22.147 25.908 1.00 52.87 ? 219 TYR B CE1 1 ATOM 6015 C CE2 . TYR B 1 219 ? 4.974 20.123 26.427 1.00 51.43 ? 219 TYR B CE2 1 ATOM 6016 C CZ . TYR B 1 219 ? 4.598 21.417 26.764 1.00 61.60 ? 219 TYR B CZ 1 ATOM 6017 O OH . TYR B 1 219 ? 5.026 21.980 27.944 1.00 62.10 ? 219 TYR B OH 1 ATOM 6018 N N . ASP B 1 220 ? 6.422 20.257 21.912 1.00 48.27 ? 220 ASP B N 1 ATOM 6019 C CA . ASP B 1 220 ? 7.810 19.828 21.887 1.00 49.30 ? 220 ASP B CA 1 ATOM 6020 C C . ASP B 1 220 ? 8.322 19.965 23.310 1.00 54.89 ? 220 ASP B C 1 ATOM 6021 O O . ASP B 1 220 ? 8.314 21.070 23.862 1.00 54.41 ? 220 ASP B O 1 ATOM 6022 C CB . ASP B 1 220 ? 8.642 20.699 20.915 1.00 51.60 ? 220 ASP B CB 1 ATOM 6023 C CG . ASP B 1 220 ? 10.143 20.688 21.183 1.00 67.29 ? 220 ASP B CG 1 ATOM 6024 O OD1 . ASP B 1 220 ? 10.750 19.586 21.138 1.00 70.98 ? 220 ASP B OD1 1 ATOM 6025 O OD2 . ASP B 1 220 ? 10.708 21.780 21.464 1.00 68.35 ? 220 ASP B OD2 1 ATOM 6026 N N . THR B 1 221 ? 8.725 18.844 23.916 1.00 52.29 ? 221 THR B N 1 ATOM 6027 C CA . THR B 1 221 ? 9.265 18.852 25.266 1.00 52.53 ? 221 THR B CA 1 ATOM 6028 C C . THR B 1 221 ? 10.773 18.902 25.165 1.00 57.64 ? 221 THR B C 1 ATOM 6029 O O . THR B 1 221 ? 11.381 18.202 24.338 1.00 57.37 ? 221 THR B O 1 ATOM 6030 C CB . THR B 1 221 ? 8.694 17.703 26.124 1.00 63.04 ? 221 THR B CB 1 ATOM 6031 O OG1 . THR B 1 221 ? 7.272 17.828 26.185 1.00 67.78 ? 221 THR B OG1 1 ATOM 6032 C CG2 . THR B 1 221 ? 9.244 17.684 27.549 1.00 58.51 ? 221 THR B CG2 1 ATOM 6033 N N . ARG B 1 222 ? 11.357 19.816 25.962 1.00 54.65 ? 222 ARG B N 1 ATOM 6034 C CA . ARG B 1 222 ? 12.791 20.021 26.131 1.00 54.13 ? 222 ARG B CA 1 ATOM 6035 C C . ARG B 1 222 ? 13.268 18.731 26.860 1.00 56.46 ? 222 ARG B C 1 ATOM 6036 O O . ARG B 1 222 ? 12.869 18.500 28.021 1.00 57.19 ? 222 ARG B O 1 ATOM 6037 C CB . ARG B 1 222 ? 13.032 21.326 26.946 1.00 53.98 ? 222 ARG B CB 1 ATOM 6038 C CG . ARG B 1 222 ? 14.334 21.415 27.751 1.00 66.78 ? 222 ARG B CG 1 ATOM 6039 C CD . ARG B 1 222 ? 14.047 21.433 29.248 1.00 77.39 ? 222 ARG B CD 1 ATOM 6040 N NE . ARG B 1 222 ? 15.256 21.661 30.043 1.00 83.03 ? 222 ARG B NE 1 ATOM 6041 C CZ . ARG B 1 222 ? 15.263 22.152 31.281 1.00 91.73 ? 222 ARG B CZ 1 ATOM 6042 N NH1 . ARG B 1 222 ? 14.124 22.478 31.882 1.00 70.26 ? 222 ARG B NH1 1 ATOM 6043 N NH2 . ARG B 1 222 ? 16.411 22.326 31.925 1.00 79.82 ? 222 ARG B NH2 1 ATOM 6044 N N A CYS B 1 223 ? 14.067 17.890 26.146 0.50 50.53 ? 223 CYS B N 1 ATOM 6045 N N B CYS B 1 223 ? 14.067 17.886 26.157 0.50 51.05 ? 223 CYS B N 1 ATOM 6046 C CA A CYS B 1 223 ? 14.617 16.596 26.580 0.50 48.98 ? 223 CYS B CA 1 ATOM 6047 C CA B CYS B 1 223 ? 14.643 16.624 26.646 0.50 49.76 ? 223 CYS B CA 1 ATOM 6048 C C A CYS B 1 223 ? 13.631 15.806 27.441 0.50 49.39 ? 223 CYS B C 1 ATOM 6049 C C B CYS B 1 223 ? 13.624 15.809 27.461 0.50 49.75 ? 223 CYS B C 1 ATOM 6050 O O A CYS B 1 223 ? 13.784 15.740 28.663 0.50 49.47 ? 223 CYS B O 1 ATOM 6051 O O B CYS B 1 223 ? 13.755 15.728 28.684 0.50 49.84 ? 223 CYS B O 1 ATOM 6052 C CB A CYS B 1 223 ? 15.991 16.737 27.243 0.50 49.25 ? 223 CYS B CB 1 ATOM 6053 C CB B CYS B 1 223 ? 15.928 16.885 27.437 0.50 50.32 ? 223 CYS B CB 1 ATOM 6054 S SG A CYS B 1 223 ? 16.129 18.103 28.427 0.50 53.05 ? 223 CYS B SG 1 ATOM 6055 S SG B CYS B 1 223 ? 17.161 17.890 26.560 0.50 54.37 ? 223 CYS B SG 1 ATOM 6056 N N . PHE B 1 224 ? 12.585 15.258 26.788 1.00 42.92 ? 224 PHE B N 1 ATOM 6057 C CA . PHE B 1 224 ? 11.475 14.504 27.413 1.00 40.29 ? 224 PHE B CA 1 ATOM 6058 C C . PHE B 1 224 ? 11.886 13.389 28.361 1.00 39.24 ? 224 PHE B C 1 ATOM 6059 O O . PHE B 1 224 ? 11.291 13.263 29.428 1.00 36.20 ? 224 PHE B O 1 ATOM 6060 C CB . PHE B 1 224 ? 10.504 13.945 26.360 1.00 41.84 ? 224 PHE B CB 1 ATOM 6061 C CG . PHE B 1 224 ? 9.225 13.344 26.924 1.00 42.18 ? 224 PHE B CG 1 ATOM 6062 C CD1 . PHE B 1 224 ? 9.157 11.995 27.262 1.00 43.67 ? 224 PHE B CD1 1 ATOM 6063 C CD2 . PHE B 1 224 ? 8.089 14.123 27.094 1.00 42.62 ? 224 PHE B CD2 1 ATOM 6064 C CE1 . PHE B 1 224 ? 7.998 11.453 27.809 1.00 43.86 ? 224 PHE B CE1 1 ATOM 6065 C CE2 . PHE B 1 224 ? 6.924 13.572 27.621 1.00 45.29 ? 224 PHE B CE2 1 ATOM 6066 C CZ . PHE B 1 224 ? 6.887 12.242 27.977 1.00 43.34 ? 224 PHE B CZ 1 ATOM 6067 N N . ASP B 1 225 ? 12.879 12.581 27.963 1.00 35.51 ? 225 ASP B N 1 ATOM 6068 C CA . ASP B 1 225 ? 13.416 11.475 28.756 1.00 34.45 ? 225 ASP B CA 1 ATOM 6069 C C . ASP B 1 225 ? 13.908 11.985 30.095 1.00 38.62 ? 225 ASP B C 1 ATOM 6070 O O . ASP B 1 225 ? 13.564 11.408 31.126 1.00 41.46 ? 225 ASP B O 1 ATOM 6071 C CB . ASP B 1 225 ? 14.549 10.761 27.994 1.00 35.62 ? 225 ASP B CB 1 ATOM 6072 C CG . ASP B 1 225 ? 14.116 9.741 26.945 1.00 40.34 ? 225 ASP B CG 1 ATOM 6073 O OD1 . ASP B 1 225 ? 12.895 9.646 26.665 1.00 38.29 ? 225 ASP B OD1 1 ATOM 6074 O OD2 . ASP B 1 225 ? 14.996 9.014 26.426 1.00 48.16 ? 225 ASP B OD2 1 ATOM 6075 N N . SER B 1 226 ? 14.624 13.113 30.091 1.00 32.56 ? 226 SER B N 1 ATOM 6076 C CA . SER B 1 226 ? 15.141 13.743 31.298 1.00 32.38 ? 226 SER B CA 1 ATOM 6077 C C . SER B 1 226 ? 14.063 14.343 32.226 1.00 35.98 ? 226 SER B C 1 ATOM 6078 O O . SER B 1 226 ? 14.351 14.552 33.404 1.00 36.82 ? 226 SER B O 1 ATOM 6079 C CB . SER B 1 226 ? 16.191 14.781 30.935 1.00 36.91 ? 226 SER B CB 1 ATOM 6080 O OG . SER B 1 226 ? 17.269 14.124 30.290 1.00 48.94 ? 226 SER B OG 1 ATOM 6081 N N . THR B 1 227 ? 12.829 14.586 31.717 1.00 30.75 ? 227 THR B N 1 ATOM 6082 C CA . THR B 1 227 ? 11.692 15.129 32.480 1.00 29.49 ? 227 THR B CA 1 ATOM 6083 C C . THR B 1 227 ? 10.917 14.003 33.196 1.00 33.29 ? 227 THR B C 1 ATOM 6084 O O . THR B 1 227 ? 10.134 14.257 34.130 1.00 32.29 ? 227 THR B O 1 ATOM 6085 C CB . THR B 1 227 ? 10.737 15.967 31.579 1.00 30.58 ? 227 THR B CB 1 ATOM 6086 O OG1 . THR B 1 227 ? 9.887 15.098 30.822 1.00 29.35 ? 227 THR B OG1 1 ATOM 6087 C CG2 . THR B 1 227 ? 11.461 17.006 30.683 1.00 22.50 ? 227 THR B CG2 1 ATOM 6088 N N . VAL B 1 228 ? 11.100 12.762 32.709 1.00 30.13 ? 228 VAL B N 1 ATOM 6089 C CA . VAL B 1 228 ? 10.418 11.592 33.254 1.00 29.75 ? 228 VAL B CA 1 ATOM 6090 C C . VAL B 1 228 ? 10.997 11.318 34.651 1.00 34.74 ? 228 VAL B C 1 ATOM 6091 O O . VAL B 1 228 ? 12.211 11.178 34.814 1.00 34.46 ? 228 VAL B O 1 ATOM 6092 C CB . VAL B 1 228 ? 10.481 10.380 32.291 1.00 33.26 ? 228 VAL B CB 1 ATOM 6093 C CG1 . VAL B 1 228 ? 9.760 9.170 32.877 1.00 32.95 ? 228 VAL B CG1 1 ATOM 6094 C CG2 . VAL B 1 228 ? 9.890 10.734 30.936 1.00 33.05 ? 228 VAL B CG2 1 ATOM 6095 N N . THR B 1 229 ? 10.116 11.331 35.655 1.00 30.96 ? 229 THR B N 1 ATOM 6096 C CA . THR B 1 229 ? 10.430 11.180 37.079 1.00 29.88 ? 229 THR B CA 1 ATOM 6097 C C . THR B 1 229 ? 10.094 9.770 37.555 1.00 35.84 ? 229 THR B C 1 ATOM 6098 O O . THR B 1 229 ? 9.372 9.060 36.861 1.00 34.72 ? 229 THR B O 1 ATOM 6099 C CB . THR B 1 229 ? 9.589 12.190 37.883 1.00 22.23 ? 229 THR B CB 1 ATOM 6100 O OG1 . THR B 1 229 ? 8.232 11.806 37.771 1.00 20.26 ? 229 THR B OG1 1 ATOM 6101 C CG2 . THR B 1 229 ? 9.742 13.623 37.396 1.00 13.01 ? 229 THR B CG2 1 ATOM 6102 N N . GLU B 1 230 ? 10.567 9.384 38.769 1.00 34.77 ? 230 GLU B N 1 ATOM 6103 C CA . GLU B 1 230 ? 10.265 8.083 39.391 1.00 34.27 ? 230 GLU B CA 1 ATOM 6104 C C . GLU B 1 230 ? 8.757 7.853 39.380 1.00 37.74 ? 230 GLU B C 1 ATOM 6105 O O . GLU B 1 230 ? 8.317 6.766 39.033 1.00 37.34 ? 230 GLU B O 1 ATOM 6106 C CB . GLU B 1 230 ? 10.786 8.029 40.839 1.00 35.17 ? 230 GLU B CB 1 ATOM 6107 C CG . GLU B 1 230 ? 10.643 6.659 41.485 1.00 41.55 ? 230 GLU B CG 1 ATOM 6108 C CD . GLU B 1 230 ? 11.287 6.482 42.844 1.00 57.28 ? 230 GLU B CD 1 ATOM 6109 O OE1 . GLU B 1 230 ? 12.325 7.129 43.108 1.00 50.42 ? 230 GLU B OE1 1 ATOM 6110 O OE2 . GLU B 1 230 ? 10.775 5.658 43.634 1.00 55.77 ? 230 GLU B OE2 1 ATOM 6111 N N . ASN B 1 231 ? 7.980 8.891 39.732 1.00 34.93 ? 231 ASN B N 1 ATOM 6112 C CA . ASN B 1 231 ? 6.527 8.839 39.753 1.00 35.53 ? 231 ASN B CA 1 ATOM 6113 C C . ASN B 1 231 ? 5.990 8.321 38.420 1.00 40.52 ? 231 ASN B C 1 ATOM 6114 O O . ASN B 1 231 ? 5.263 7.327 38.409 1.00 39.61 ? 231 ASN B O 1 ATOM 6115 C CB . ASN B 1 231 ? 5.916 10.206 40.084 1.00 34.88 ? 231 ASN B CB 1 ATOM 6116 C CG . ASN B 1 231 ? 4.414 10.165 39.968 1.00 45.27 ? 231 ASN B CG 1 ATOM 6117 O OD1 . ASN B 1 231 ? 3.734 9.468 40.751 1.00 27.24 ? 231 ASN B OD1 1 ATOM 6118 N ND2 . ASN B 1 231 ? 3.895 10.769 38.885 1.00 31.92 ? 231 ASN B ND2 1 ATOM 6119 N N . ASP B 1 232 ? 6.390 8.980 37.304 1.00 37.03 ? 232 ASP B N 1 ATOM 6120 C CA . ASP B 1 232 ? 6.001 8.643 35.938 1.00 35.72 ? 232 ASP B CA 1 ATOM 6121 C C . ASP B 1 232 ? 6.299 7.190 35.579 1.00 38.72 ? 232 ASP B C 1 ATOM 6122 O O . ASP B 1 232 ? 5.464 6.543 34.961 1.00 38.77 ? 232 ASP B O 1 ATOM 6123 C CB . ASP B 1 232 ? 6.670 9.587 34.927 1.00 36.77 ? 232 ASP B CB 1 ATOM 6124 C CG . ASP B 1 232 ? 6.428 11.070 35.147 1.00 37.72 ? 232 ASP B CG 1 ATOM 6125 O OD1 . ASP B 1 232 ? 5.296 11.437 35.539 1.00 37.20 ? 232 ASP B OD1 1 ATOM 6126 O OD2 . ASP B 1 232 ? 7.341 11.868 34.849 1.00 40.34 ? 232 ASP B OD2 1 ATOM 6127 N N . ILE B 1 233 ? 7.455 6.672 35.994 1.00 35.28 ? 233 ILE B N 1 ATOM 6128 C CA . ILE B 1 233 ? 7.859 5.294 35.694 1.00 36.03 ? 233 ILE B CA 1 ATOM 6129 C C . ILE B 1 233 ? 7.039 4.266 36.526 1.00 40.57 ? 233 ILE B C 1 ATOM 6130 O O . ILE B 1 233 ? 6.700 3.197 35.999 1.00 40.62 ? 233 ILE B O 1 ATOM 6131 C CB . ILE B 1 233 ? 9.406 5.115 35.797 1.00 39.23 ? 233 ILE B CB 1 ATOM 6132 C CG1 . ILE B 1 233 ? 10.116 6.005 34.736 1.00 39.72 ? 233 ILE B CG1 1 ATOM 6133 C CG2 . ILE B 1 233 ? 9.811 3.646 35.594 1.00 39.95 ? 233 ILE B CG2 1 ATOM 6134 C CD1 . ILE B 1 233 ? 11.390 6.721 35.214 1.00 47.54 ? 233 ILE B CD1 1 ATOM 6135 N N . ARG B 1 234 ? 6.687 4.612 37.788 1.00 36.06 ? 234 ARG B N 1 ATOM 6136 C CA . ARG B 1 234 ? 5.867 3.783 38.687 1.00 34.51 ? 234 ARG B CA 1 ATOM 6137 C C . ARG B 1 234 ? 4.419 3.799 38.202 1.00 38.74 ? 234 ARG B C 1 ATOM 6138 O O . ARG B 1 234 ? 3.743 2.775 38.251 1.00 41.08 ? 234 ARG B O 1 ATOM 6139 C CB . ARG B 1 234 ? 5.931 4.301 40.126 1.00 31.56 ? 234 ARG B CB 1 ATOM 6140 C CG . ARG B 1 234 ? 7.324 4.315 40.713 1.00 36.18 ? 234 ARG B CG 1 ATOM 6141 C CD . ARG B 1 234 ? 7.277 4.344 42.219 1.00 44.50 ? 234 ARG B CD 1 ATOM 6142 N NE . ARG B 1 234 ? 8.602 4.143 42.801 1.00 39.89 ? 234 ARG B NE 1 ATOM 6143 C CZ . ARG B 1 234 ? 9.146 2.957 43.033 1.00 41.46 ? 234 ARG B CZ 1 ATOM 6144 N NH1 . ARG B 1 234 ? 8.503 1.845 42.694 1.00 32.69 ? 234 ARG B NH1 1 ATOM 6145 N NH2 . ARG B 1 234 ? 10.363 2.871 43.547 1.00 19.79 ? 234 ARG B NH2 1 ATOM 6146 N N . VAL B 1 235 ? 3.954 4.962 37.714 1.00 32.20 ? 235 VAL B N 1 ATOM 6147 C CA . VAL B 1 235 ? 2.627 5.148 37.152 1.00 30.32 ? 235 VAL B CA 1 ATOM 6148 C C . VAL B 1 235 ? 2.488 4.197 35.952 1.00 33.92 ? 235 VAL B C 1 ATOM 6149 O O . VAL B 1 235 ? 1.523 3.438 35.911 1.00 34.77 ? 235 VAL B O 1 ATOM 6150 C CB . VAL B 1 235 ? 2.341 6.647 36.820 1.00 32.72 ? 235 VAL B CB 1 ATOM 6151 C CG1 . VAL B 1 235 ? 1.224 6.803 35.792 1.00 32.38 ? 235 VAL B CG1 1 ATOM 6152 C CG2 . VAL B 1 235 ? 2.009 7.433 38.086 1.00 31.68 ? 235 VAL B CG2 1 ATOM 6153 N N . GLU B 1 236 ? 3.489 4.191 35.033 1.00 28.17 ? 236 GLU B N 1 ATOM 6154 C CA . GLU B 1 236 ? 3.575 3.331 33.858 1.00 27.06 ? 236 GLU B CA 1 ATOM 6155 C C . GLU B 1 236 ? 3.450 1.874 34.260 1.00 31.02 ? 236 GLU B C 1 ATOM 6156 O O . GLU B 1 236 ? 2.675 1.145 33.643 1.00 31.01 ? 236 GLU B O 1 ATOM 6157 C CB . GLU B 1 236 ? 4.930 3.513 33.178 1.00 28.74 ? 236 GLU B CB 1 ATOM 6158 C CG . GLU B 1 236 ? 5.047 4.716 32.267 1.00 42.83 ? 236 GLU B CG 1 ATOM 6159 C CD . GLU B 1 236 ? 6.474 5.172 32.005 1.00 58.21 ? 236 GLU B CD 1 ATOM 6160 O OE1 . GLU B 1 236 ? 7.366 4.312 31.803 1.00 45.11 ? 236 GLU B OE1 1 ATOM 6161 O OE2 . GLU B 1 236 ? 6.691 6.404 31.980 1.00 44.48 ? 236 GLU B OE2 1 ATOM 6162 N N . GLU B 1 237 ? 4.217 1.444 35.298 1.00 27.92 ? 237 GLU B N 1 ATOM 6163 C CA . GLU B 1 237 ? 4.215 0.074 35.825 1.00 27.86 ? 237 GLU B CA 1 ATOM 6164 C C . GLU B 1 237 ? 2.821 -0.295 36.283 1.00 33.07 ? 237 GLU B C 1 ATOM 6165 O O . GLU B 1 237 ? 2.313 -1.339 35.866 1.00 32.81 ? 237 GLU B O 1 ATOM 6166 C CB . GLU B 1 237 ? 5.219 -0.078 36.978 1.00 29.23 ? 237 GLU B CB 1 ATOM 6167 C CG . GLU B 1 237 ? 5.520 -1.519 37.359 1.00 37.82 ? 237 GLU B CG 1 ATOM 6168 C CD . GLU B 1 237 ? 4.889 -2.007 38.648 1.00 65.58 ? 237 GLU B CD 1 ATOM 6169 O OE1 . GLU B 1 237 ? 4.302 -1.181 39.387 1.00 68.69 ? 237 GLU B OE1 1 ATOM 6170 O OE2 . GLU B 1 237 ? 4.990 -3.225 38.922 1.00 60.98 ? 237 GLU B OE2 1 ATOM 6171 N N . SER B 1 238 ? 2.179 0.590 37.084 1.00 30.14 ? 238 SER B N 1 ATOM 6172 C CA . SER B 1 238 ? 0.815 0.397 37.559 1.00 30.90 ? 238 SER B CA 1 ATOM 6173 C C . SER B 1 238 ? -0.169 0.230 36.387 1.00 36.77 ? 238 SER B C 1 ATOM 6174 O O . SER B 1 238 ? -1.107 -0.571 36.505 1.00 39.56 ? 238 SER B O 1 ATOM 6175 C CB . SER B 1 238 ? 0.391 1.520 38.503 1.00 35.37 ? 238 SER B CB 1 ATOM 6176 O OG . SER B 1 238 ? -0.186 2.624 37.825 1.00 47.54 ? 238 SER B OG 1 ATOM 6177 N N . ILE B 1 239 ? 0.067 0.946 35.252 1.00 30.04 ? 239 ILE B N 1 ATOM 6178 C CA . ILE B 1 239 ? -0.744 0.826 34.036 1.00 28.93 ? 239 ILE B CA 1 ATOM 6179 C C . ILE B 1 239 ? -0.540 -0.587 33.463 1.00 33.21 ? 239 ILE B C 1 ATOM 6180 O O . ILE B 1 239 ? -1.517 -1.316 33.282 1.00 31.48 ? 239 ILE B O 1 ATOM 6181 C CB . ILE B 1 239 ? -0.472 1.952 32.993 1.00 30.79 ? 239 ILE B CB 1 ATOM 6182 C CG1 . ILE B 1 239 ? -0.895 3.330 33.531 1.00 29.07 ? 239 ILE B CG1 1 ATOM 6183 C CG2 . ILE B 1 239 ? -1.158 1.639 31.646 1.00 31.80 ? 239 ILE B CG2 1 ATOM 6184 C CD1 . ILE B 1 239 ? -0.190 4.526 32.868 1.00 28.12 ? 239 ILE B CD1 1 ATOM 6185 N N . TYR B 1 240 ? 0.735 -0.989 33.247 1.00 31.86 ? 240 TYR B N 1 ATOM 6186 C CA . TYR B 1 240 ? 1.087 -2.328 32.735 1.00 32.02 ? 240 TYR B CA 1 ATOM 6187 C C . TYR B 1 240 ? 0.435 -3.406 33.606 1.00 35.19 ? 240 TYR B C 1 ATOM 6188 O O . TYR B 1 240 ? -0.197 -4.318 33.086 1.00 32.90 ? 240 TYR B O 1 ATOM 6189 C CB . TYR B 1 240 ? 2.613 -2.550 32.707 1.00 33.16 ? 240 TYR B CB 1 ATOM 6190 C CG . TYR B 1 240 ? 3.450 -1.507 31.991 1.00 35.08 ? 240 TYR B CG 1 ATOM 6191 C CD1 . TYR B 1 240 ? 2.966 -0.842 30.869 1.00 37.23 ? 240 TYR B CD1 1 ATOM 6192 C CD2 . TYR B 1 240 ? 4.770 -1.273 32.364 1.00 36.02 ? 240 TYR B CD2 1 ATOM 6193 C CE1 . TYR B 1 240 ? 3.748 0.087 30.184 1.00 38.49 ? 240 TYR B CE1 1 ATOM 6194 C CE2 . TYR B 1 240 ? 5.561 -0.350 31.687 1.00 37.16 ? 240 TYR B CE2 1 ATOM 6195 C CZ . TYR B 1 240 ? 5.046 0.334 30.601 1.00 46.89 ? 240 TYR B CZ 1 ATOM 6196 O OH . TYR B 1 240 ? 5.834 1.253 29.947 1.00 51.61 ? 240 TYR B OH 1 ATOM 6197 N N . GLN B 1 241 ? 0.526 -3.235 34.938 1.00 33.42 ? 241 GLN B N 1 ATOM 6198 C CA . GLN B 1 241 ? -0.016 -4.144 35.958 1.00 33.14 ? 241 GLN B CA 1 ATOM 6199 C C . GLN B 1 241 ? -1.535 -4.301 35.908 1.00 36.35 ? 241 GLN B C 1 ATOM 6200 O O . GLN B 1 241 ? -2.038 -5.252 36.493 1.00 35.56 ? 241 GLN B O 1 ATOM 6201 C CB . GLN B 1 241 ? 0.460 -3.755 37.373 1.00 33.86 ? 241 GLN B CB 1 ATOM 6202 C CG . GLN B 1 241 ? 1.952 -4.013 37.612 1.00 26.85 ? 241 GLN B CG 1 ATOM 6203 C CD . GLN B 1 241 ? 2.337 -5.466 37.613 1.00 39.80 ? 241 GLN B CD 1 ATOM 6204 O OE1 . GLN B 1 241 ? 1.516 -6.353 37.876 1.00 42.10 ? 241 GLN B OE1 1 ATOM 6205 N NE2 . GLN B 1 241 ? 3.617 -5.736 37.374 1.00 22.77 ? 241 GLN B NE2 1 ATOM 6206 N N . CYS B 1 242 ? -2.261 -3.419 35.185 1.00 33.09 ? 242 CYS B N 1 ATOM 6207 C CA . CYS B 1 242 ? -3.714 -3.573 35.035 1.00 32.94 ? 242 CYS B CA 1 ATOM 6208 C C . CYS B 1 242 ? -4.047 -4.715 34.092 1.00 37.32 ? 242 CYS B C 1 ATOM 6209 O O . CYS B 1 242 ? -5.118 -5.291 34.225 1.00 38.84 ? 242 CYS B O 1 ATOM 6210 C CB . CYS B 1 242 ? -4.370 -2.278 34.576 1.00 33.01 ? 242 CYS B CB 1 ATOM 6211 S SG . CYS B 1 242 ? -4.246 -0.931 35.771 1.00 36.69 ? 242 CYS B SG 1 ATOM 6212 N N . CYS B 1 243 ? -3.141 -5.037 33.135 1.00 32.63 ? 243 CYS B N 1 ATOM 6213 C CA . CYS B 1 243 ? -3.299 -6.105 32.141 1.00 31.90 ? 243 CYS B CA 1 ATOM 6214 C C . CYS B 1 243 ? -3.507 -7.455 32.790 1.00 36.96 ? 243 CYS B C 1 ATOM 6215 O O . CYS B 1 243 ? -3.052 -7.670 33.918 1.00 37.42 ? 243 CYS B O 1 ATOM 6216 C CB . CYS B 1 243 ? -2.082 -6.163 31.219 1.00 31.80 ? 243 CYS B CB 1 ATOM 6217 S SG . CYS B 1 243 ? -1.829 -4.698 30.197 1.00 35.47 ? 243 CYS B SG 1 ATOM 6218 N N . ASP B 1 244 ? -4.112 -8.397 32.036 1.00 32.98 ? 244 ASP B N 1 ATOM 6219 C CA . ASP B 1 244 ? -4.219 -9.799 32.429 1.00 32.80 ? 244 ASP B CA 1 ATOM 6220 C C . ASP B 1 244 ? -2.818 -10.315 32.043 1.00 37.36 ? 244 ASP B C 1 ATOM 6221 O O . ASP B 1 244 ? -2.459 -10.347 30.857 1.00 37.05 ? 244 ASP B O 1 ATOM 6222 C CB . ASP B 1 244 ? -5.331 -10.517 31.627 1.00 34.52 ? 244 ASP B CB 1 ATOM 6223 C CG . ASP B 1 244 ? -5.591 -11.983 31.951 1.00 43.07 ? 244 ASP B CG 1 ATOM 6224 O OD1 . ASP B 1 244 ? -4.630 -12.695 32.334 1.00 43.48 ? 244 ASP B OD1 1 ATOM 6225 O OD2 . ASP B 1 244 ? -6.742 -12.435 31.760 1.00 49.41 ? 244 ASP B OD2 1 ATOM 6226 N N . LEU B 1 245 ? -2.004 -10.589 33.061 1.00 34.16 ? 245 LEU B N 1 ATOM 6227 C CA . LEU B 1 245 ? -0.620 -11.013 32.906 1.00 34.45 ? 245 LEU B CA 1 ATOM 6228 C C . LEU B 1 245 ? -0.324 -12.299 33.646 1.00 39.13 ? 245 LEU B C 1 ATOM 6229 O O . LEU B 1 245 ? -0.973 -12.609 34.645 1.00 39.38 ? 245 LEU B O 1 ATOM 6230 C CB . LEU B 1 245 ? 0.309 -9.923 33.466 1.00 34.67 ? 245 LEU B CB 1 ATOM 6231 C CG . LEU B 1 245 ? 0.405 -8.609 32.700 1.00 39.08 ? 245 LEU B CG 1 ATOM 6232 C CD1 . LEU B 1 245 ? 0.902 -7.510 33.615 1.00 38.84 ? 245 LEU B CD1 1 ATOM 6233 C CD2 . LEU B 1 245 ? 1.315 -8.746 31.459 1.00 41.02 ? 245 LEU B CD2 1 ATOM 6234 N N . ALA B 1 246 ? 0.705 -13.015 33.193 1.00 35.94 ? 246 ALA B N 1 ATOM 6235 C CA . ALA B 1 246 ? 1.175 -14.226 33.841 1.00 36.04 ? 246 ALA B CA 1 ATOM 6236 C C . ALA B 1 246 ? 1.853 -13.779 35.155 1.00 42.90 ? 246 ALA B C 1 ATOM 6237 O O . ALA B 1 246 ? 2.470 -12.712 35.160 1.00 42.60 ? 246 ALA B O 1 ATOM 6238 C CB . ALA B 1 246 ? 2.184 -14.922 32.942 1.00 36.32 ? 246 ALA B CB 1 ATOM 6239 N N . PRO B 1 247 ? 1.733 -14.517 36.283 1.00 41.14 ? 247 PRO B N 1 ATOM 6240 C CA . PRO B 1 247 ? 2.388 -14.064 37.535 1.00 41.56 ? 247 PRO B CA 1 ATOM 6241 C C . PRO B 1 247 ? 3.891 -13.816 37.409 1.00 45.67 ? 247 PRO B C 1 ATOM 6242 O O . PRO B 1 247 ? 4.423 -12.903 38.035 1.00 46.52 ? 247 PRO B O 1 ATOM 6243 C CB . PRO B 1 247 ? 2.062 -15.175 38.534 1.00 43.48 ? 247 PRO B CB 1 ATOM 6244 C CG . PRO B 1 247 ? 0.820 -15.808 37.982 1.00 47.69 ? 247 PRO B CG 1 ATOM 6245 C CD . PRO B 1 247 ? 1.004 -15.778 36.494 1.00 42.67 ? 247 PRO B CD 1 ATOM 6246 N N . GLU B 1 248 ? 4.556 -14.621 36.588 1.00 41.61 ? 248 GLU B N 1 ATOM 6247 C CA . GLU B 1 248 ? 5.971 -14.559 36.242 1.00 41.34 ? 248 GLU B CA 1 ATOM 6248 C C . GLU B 1 248 ? 6.237 -13.168 35.574 1.00 44.13 ? 248 GLU B C 1 ATOM 6249 O O . GLU B 1 248 ? 7.145 -12.455 36.009 1.00 45.24 ? 248 GLU B O 1 ATOM 6250 C CB . GLU B 1 248 ? 6.233 -15.736 35.279 1.00 43.13 ? 248 GLU B CB 1 ATOM 6251 C CG . GLU B 1 248 ? 7.680 -16.059 34.966 1.00 61.37 ? 248 GLU B CG 1 ATOM 6252 C CD . GLU B 1 248 ? 7.868 -17.097 33.866 1.00 100.68 ? 248 GLU B CD 1 ATOM 6253 O OE1 . GLU B 1 248 ? 6.966 -17.243 33.006 1.00 95.10 ? 248 GLU B OE1 1 ATOM 6254 O OE2 . GLU B 1 248 ? 8.937 -17.750 33.853 1.00 102.67 ? 248 GLU B OE2 1 ATOM 6255 N N . ALA B 1 249 ? 5.379 -12.763 34.586 1.00 36.62 ? 249 ALA B N 1 ATOM 6256 C CA . ALA B 1 249 ? 5.408 -11.481 33.878 1.00 34.68 ? 249 ALA B CA 1 ATOM 6257 C C . ALA B 1 249 ? 5.236 -10.292 34.816 1.00 36.65 ? 249 ALA B C 1 ATOM 6258 O O . ALA B 1 249 ? 6.043 -9.375 34.728 1.00 37.55 ? 249 ALA B O 1 ATOM 6259 C CB . ALA B 1 249 ? 4.348 -11.445 32.794 1.00 35.26 ? 249 ALA B CB 1 ATOM 6260 N N . ARG B 1 250 ? 4.216 -10.300 35.717 1.00 31.03 ? 250 ARG B N 1 ATOM 6261 C CA . ARG B 1 250 ? 3.977 -9.235 36.715 1.00 30.52 ? 250 ARG B CA 1 ATOM 6262 C C . ARG B 1 250 ? 5.246 -8.986 37.514 1.00 34.97 ? 250 ARG B C 1 ATOM 6263 O O . ARG B 1 250 ? 5.705 -7.847 37.597 1.00 34.82 ? 250 ARG B O 1 ATOM 6264 C CB . ARG B 1 250 ? 2.889 -9.621 37.724 1.00 28.02 ? 250 ARG B CB 1 ATOM 6265 C CG . ARG B 1 250 ? 1.553 -9.913 37.120 1.00 34.76 ? 250 ARG B CG 1 ATOM 6266 C CD . ARG B 1 250 ? 0.445 -9.743 38.133 1.00 28.53 ? 250 ARG B CD 1 ATOM 6267 N NE . ARG B 1 250 ? -0.846 -9.919 37.472 1.00 45.92 ? 250 ARG B NE 1 ATOM 6268 C CZ . ARG B 1 250 ? -1.478 -8.957 36.813 1.00 61.92 ? 250 ARG B CZ 1 ATOM 6269 N NH1 . ARG B 1 250 ? -0.958 -7.741 36.745 1.00 47.14 ? 250 ARG B NH1 1 ATOM 6270 N NH2 . ARG B 1 250 ? -2.640 -9.203 36.221 1.00 51.73 ? 250 ARG B NH2 1 ATOM 6271 N N . GLN B 1 251 ? 5.808 -10.070 38.085 1.00 31.46 ? 251 GLN B N 1 ATOM 6272 C CA . GLN B 1 251 ? 7.028 -10.060 38.875 1.00 31.92 ? 251 GLN B CA 1 ATOM 6273 C C . GLN B 1 251 ? 8.176 -9.488 38.076 1.00 37.57 ? 251 GLN B C 1 ATOM 6274 O O . GLN B 1 251 ? 8.879 -8.619 38.591 1.00 38.32 ? 251 GLN B O 1 ATOM 6275 C CB . GLN B 1 251 ? 7.366 -11.473 39.382 1.00 33.44 ? 251 GLN B CB 1 ATOM 6276 C CG . GLN B 1 251 ? 8.656 -11.564 40.203 1.00 36.73 ? 251 GLN B CG 1 ATOM 6277 C CD . GLN B 1 251 ? 8.538 -11.046 41.608 1.00 51.47 ? 251 GLN B CD 1 ATOM 6278 O OE1 . GLN B 1 251 ? 7.702 -10.193 41.933 1.00 38.49 ? 251 GLN B OE1 1 ATOM 6279 N NE2 . GLN B 1 251 ? 9.380 -11.571 42.484 1.00 57.57 ? 251 GLN B NE2 1 ATOM 6280 N N . ALA B 1 252 ? 8.355 -9.958 36.819 1.00 33.72 ? 252 ALA B N 1 ATOM 6281 C CA . ALA B 1 252 ? 9.400 -9.472 35.922 1.00 32.74 ? 252 ALA B CA 1 ATOM 6282 C C . ALA B 1 252 ? 9.227 -7.967 35.636 1.00 36.57 ? 252 ALA B C 1 ATOM 6283 O O . ALA B 1 252 ? 10.221 -7.236 35.646 1.00 36.55 ? 252 ALA B O 1 ATOM 6284 C CB . ALA B 1 252 ? 9.392 -10.264 34.638 1.00 33.16 ? 252 ALA B CB 1 ATOM 6285 N N . ILE B 1 253 ? 7.966 -7.498 35.460 1.00 31.93 ? 253 ILE B N 1 ATOM 6286 C CA . ILE B 1 253 ? 7.667 -6.083 35.207 1.00 31.27 ? 253 ILE B CA 1 ATOM 6287 C C . ILE B 1 253 ? 8.063 -5.253 36.428 1.00 34.20 ? 253 ILE B C 1 ATOM 6288 O O . ILE B 1 253 ? 8.763 -4.249 36.267 1.00 34.41 ? 253 ILE B O 1 ATOM 6289 C CB . ILE B 1 253 ? 6.200 -5.839 34.701 1.00 34.06 ? 253 ILE B CB 1 ATOM 6290 C CG1 . ILE B 1 253 ? 6.011 -6.466 33.298 1.00 34.30 ? 253 ILE B CG1 1 ATOM 6291 C CG2 . ILE B 1 253 ? 5.851 -4.341 34.650 1.00 34.18 ? 253 ILE B CG2 1 ATOM 6292 C CD1 . ILE B 1 253 ? 4.577 -6.862 32.884 1.00 40.11 ? 253 ILE B CD1 1 ATOM 6293 N N . LYS B 1 254 ? 7.689 -5.722 37.641 1.00 29.27 ? 254 LYS B N 1 ATOM 6294 C CA . LYS B 1 254 ? 7.991 -5.067 38.920 1.00 28.71 ? 254 LYS B CA 1 ATOM 6295 C C . LYS B 1 254 ? 9.500 -4.934 39.140 1.00 34.10 ? 254 LYS B C 1 ATOM 6296 O O . LYS B 1 254 ? 9.960 -3.864 39.559 1.00 33.05 ? 254 LYS B O 1 ATOM 6297 C CB . LYS B 1 254 ? 7.349 -5.813 40.095 1.00 30.25 ? 254 LYS B CB 1 ATOM 6298 C CG . LYS B 1 254 ? 7.149 -4.920 41.301 1.00 40.32 ? 254 LYS B CG 1 ATOM 6299 C CD . LYS B 1 254 ? 7.389 -5.644 42.607 1.00 50.69 ? 254 LYS B CD 1 ATOM 6300 C CE . LYS B 1 254 ? 7.248 -4.721 43.797 1.00 67.96 ? 254 LYS B CE 1 ATOM 6301 N NZ . LYS B 1 254 ? 8.341 -3.707 43.879 1.00 74.53 ? 254 LYS B NZ 1 ATOM 6302 N N . SER B 1 255 ? 10.261 -6.021 38.824 1.00 31.00 ? 255 SER B N 1 ATOM 6303 C CA . SER B 1 255 ? 11.722 -6.096 38.913 1.00 30.51 ? 255 SER B CA 1 ATOM 6304 C C . SER B 1 255 ? 12.388 -5.180 37.886 1.00 33.93 ? 255 SER B C 1 ATOM 6305 O O . SER B 1 255 ? 13.277 -4.410 38.238 1.00 33.52 ? 255 SER B O 1 ATOM 6306 C CB . SER B 1 255 ? 12.194 -7.524 38.694 1.00 33.54 ? 255 SER B CB 1 ATOM 6307 O OG . SER B 1 255 ? 11.729 -8.336 39.750 1.00 45.49 ? 255 SER B OG 1 ATOM 6308 N N . LEU B 1 256 ? 11.960 -5.257 36.622 1.00 29.51 ? 256 LEU B N 1 ATOM 6309 C CA . LEU B 1 256 ? 12.515 -4.400 35.584 1.00 28.75 ? 256 LEU B CA 1 ATOM 6310 C C . LEU B 1 256 ? 12.229 -2.932 35.881 1.00 33.64 ? 256 LEU B C 1 ATOM 6311 O O . LEU B 1 256 ? 13.088 -2.097 35.635 1.00 32.67 ? 256 LEU B O 1 ATOM 6312 C CB . LEU B 1 256 ? 12.017 -4.798 34.184 1.00 28.17 ? 256 LEU B CB 1 ATOM 6313 C CG . LEU B 1 256 ? 12.615 -6.068 33.600 1.00 31.71 ? 256 LEU B CG 1 ATOM 6314 C CD1 . LEU B 1 256 ? 11.705 -6.663 32.560 1.00 31.39 ? 256 LEU B CD1 1 ATOM 6315 C CD2 . LEU B 1 256 ? 14.016 -5.833 33.062 1.00 31.95 ? 256 LEU B CD2 1 ATOM 6316 N N . THR B 1 257 ? 11.053 -2.615 36.448 1.00 31.21 ? 257 THR B N 1 ATOM 6317 C CA . THR B 1 257 ? 10.731 -1.233 36.802 1.00 31.31 ? 257 THR B CA 1 ATOM 6318 C C . THR B 1 257 ? 11.638 -0.719 37.927 1.00 36.64 ? 257 THR B C 1 ATOM 6319 O O . THR B 1 257 ? 12.361 0.254 37.720 1.00 37.21 ? 257 THR B O 1 ATOM 6320 C CB . THR B 1 257 ? 9.248 -1.098 37.100 1.00 33.89 ? 257 THR B CB 1 ATOM 6321 O OG1 . THR B 1 257 ? 8.536 -1.390 35.899 1.00 31.40 ? 257 THR B OG1 1 ATOM 6322 C CG2 . THR B 1 257 ? 8.881 0.286 37.626 1.00 30.19 ? 257 THR B CG2 1 ATOM 6323 N N . GLU B 1 258 ? 11.598 -1.389 39.096 1.00 32.58 ? 258 GLU B N 1 ATOM 6324 C CA . GLU B 1 258 ? 12.361 -1.056 40.292 1.00 32.20 ? 258 GLU B CA 1 ATOM 6325 C C . GLU B 1 258 ? 13.846 -0.991 40.059 1.00 34.73 ? 258 GLU B C 1 ATOM 6326 O O . GLU B 1 258 ? 14.485 -0.013 40.435 1.00 35.16 ? 258 GLU B O 1 ATOM 6327 C CB . GLU B 1 258 ? 12.065 -2.067 41.418 1.00 33.90 ? 258 GLU B CB 1 ATOM 6328 C CG . GLU B 1 258 ? 10.737 -1.853 42.133 1.00 45.81 ? 258 GLU B CG 1 ATOM 6329 C CD . GLU B 1 258 ? 10.636 -0.683 43.098 1.00 69.54 ? 258 GLU B CD 1 ATOM 6330 O OE1 . GLU B 1 258 ? 11.614 0.092 43.231 1.00 61.02 ? 258 GLU B OE1 1 ATOM 6331 O OE2 . GLU B 1 258 ? 9.565 -0.553 43.735 1.00 61.70 ? 258 GLU B OE2 1 ATOM 6332 N N . ARG B 1 259 ? 14.394 -2.028 39.436 1.00 30.69 ? 259 ARG B N 1 ATOM 6333 C CA . ARG B 1 259 ? 15.829 -2.185 39.203 1.00 29.78 ? 259 ARG B CA 1 ATOM 6334 C C . ARG B 1 259 ? 16.377 -1.488 37.970 1.00 33.80 ? 259 ARG B C 1 ATOM 6335 O O . ARG B 1 259 ? 17.495 -1.001 38.017 1.00 34.21 ? 259 ARG B O 1 ATOM 6336 C CB . ARG B 1 259 ? 16.188 -3.663 39.156 1.00 24.70 ? 259 ARG B CB 1 ATOM 6337 C CG . ARG B 1 259 ? 15.560 -4.488 40.267 1.00 27.57 ? 259 ARG B CG 1 ATOM 6338 C CD . ARG B 1 259 ? 15.766 -5.958 40.013 1.00 32.50 ? 259 ARG B CD 1 ATOM 6339 N NE . ARG B 1 259 ? 17.176 -6.228 39.741 1.00 29.81 ? 259 ARG B NE 1 ATOM 6340 C CZ . ARG B 1 259 ? 17.695 -7.424 39.532 1.00 37.53 ? 259 ARG B CZ 1 ATOM 6341 N NH1 . ARG B 1 259 ? 16.927 -8.504 39.575 1.00 28.23 ? 259 ARG B NH1 1 ATOM 6342 N NH2 . ARG B 1 259 ? 18.986 -7.554 39.277 1.00 26.21 ? 259 ARG B NH2 1 ATOM 6343 N N . LEU B 1 260 ? 15.629 -1.456 36.874 1.00 29.84 ? 260 LEU B N 1 ATOM 6344 C CA . LEU B 1 260 ? 16.125 -0.854 35.647 1.00 30.20 ? 260 LEU B CA 1 ATOM 6345 C C . LEU B 1 260 ? 15.423 0.445 35.217 1.00 36.54 ? 260 LEU B C 1 ATOM 6346 O O . LEU B 1 260 ? 16.106 1.444 35.038 1.00 37.75 ? 260 LEU B O 1 ATOM 6347 C CB . LEU B 1 260 ? 16.075 -1.904 34.512 1.00 29.94 ? 260 LEU B CB 1 ATOM 6348 C CG . LEU B 1 260 ? 16.435 -1.465 33.093 1.00 33.34 ? 260 LEU B CG 1 ATOM 6349 C CD1 . LEU B 1 260 ? 17.910 -1.087 32.978 1.00 32.29 ? 260 LEU B CD1 1 ATOM 6350 C CD2 . LEU B 1 260 ? 16.066 -2.543 32.091 1.00 34.98 ? 260 LEU B CD2 1 ATOM 6351 N N . TYR B 1 261 ? 14.095 0.424 35.005 1.00 33.51 ? 261 TYR B N 1 ATOM 6352 C CA . TYR B 1 261 ? 13.334 1.550 34.449 1.00 33.77 ? 261 TYR B CA 1 ATOM 6353 C C . TYR B 1 261 ? 13.293 2.813 35.310 1.00 39.87 ? 261 TYR B C 1 ATOM 6354 O O . TYR B 1 261 ? 13.317 3.895 34.738 1.00 40.15 ? 261 TYR B O 1 ATOM 6355 C CB . TYR B 1 261 ? 11.906 1.134 34.051 1.00 34.27 ? 261 TYR B CB 1 ATOM 6356 C CG . TYR B 1 261 ? 11.816 -0.068 33.129 1.00 34.65 ? 261 TYR B CG 1 ATOM 6357 C CD1 . TYR B 1 261 ? 12.764 -0.278 32.124 1.00 36.34 ? 261 TYR B CD1 1 ATOM 6358 C CD2 . TYR B 1 261 ? 10.747 -0.958 33.213 1.00 34.47 ? 261 TYR B CD2 1 ATOM 6359 C CE1 . TYR B 1 261 ? 12.681 -1.375 31.269 1.00 35.67 ? 261 TYR B CE1 1 ATOM 6360 C CE2 . TYR B 1 261 ? 10.647 -2.052 32.353 1.00 34.89 ? 261 TYR B CE2 1 ATOM 6361 C CZ . TYR B 1 261 ? 11.624 -2.264 31.392 1.00 40.82 ? 261 TYR B CZ 1 ATOM 6362 O OH . TYR B 1 261 ? 11.547 -3.353 30.560 1.00 39.70 ? 261 TYR B OH 1 ATOM 6363 N N . ILE B 1 262 ? 13.215 2.707 36.646 1.00 37.62 ? 262 ILE B N 1 ATOM 6364 C CA . ILE B 1 262 ? 13.189 3.900 37.521 1.00 37.84 ? 262 ILE B CA 1 ATOM 6365 C C . ILE B 1 262 ? 14.522 4.683 37.436 1.00 41.50 ? 262 ILE B C 1 ATOM 6366 O O . ILE B 1 262 ? 14.530 5.916 37.361 1.00 41.85 ? 262 ILE B O 1 ATOM 6367 C CB . ILE B 1 262 ? 12.781 3.520 38.982 1.00 40.78 ? 262 ILE B CB 1 ATOM 6368 C CG1 . ILE B 1 262 ? 11.257 3.477 39.127 1.00 40.33 ? 262 ILE B CG1 1 ATOM 6369 C CG2 . ILE B 1 262 ? 13.417 4.434 40.060 1.00 42.05 ? 262 ILE B CG2 1 ATOM 6370 C CD1 . ILE B 1 262 ? 10.808 2.478 40.085 1.00 47.13 ? 262 ILE B CD1 1 ATOM 6371 N N . GLY B 1 263 ? 15.613 3.937 37.452 1.00 37.04 ? 263 GLY B N 1 ATOM 6372 C CA . GLY B 1 263 ? 16.966 4.456 37.416 1.00 36.43 ? 263 GLY B CA 1 ATOM 6373 C C . GLY B 1 263 ? 17.975 3.364 37.683 1.00 40.35 ? 263 GLY B C 1 ATOM 6374 O O . GLY B 1 263 ? 17.617 2.199 37.875 1.00 39.03 ? 263 GLY B O 1 ATOM 6375 N N . GLY B 1 264 ? 19.236 3.756 37.704 1.00 38.31 ? 264 GLY B N 1 ATOM 6376 C CA . GLY B 1 264 ? 20.344 2.842 37.931 1.00 38.09 ? 264 GLY B CA 1 ATOM 6377 C C . GLY B 1 264 ? 21.683 3.460 37.593 1.00 41.40 ? 264 GLY B C 1 ATOM 6378 O O . GLY B 1 264 ? 21.725 4.578 37.061 1.00 41.16 ? 264 GLY B O 1 ATOM 6379 N N . PRO B 1 265 ? 22.799 2.761 37.924 1.00 36.35 ? 265 PRO B N 1 ATOM 6380 C CA . PRO B 1 265 ? 24.122 3.332 37.672 1.00 35.40 ? 265 PRO B CA 1 ATOM 6381 C C . PRO B 1 265 ? 24.466 3.329 36.199 1.00 39.50 ? 265 PRO B C 1 ATOM 6382 O O . PRO B 1 265 ? 24.019 2.446 35.467 1.00 39.28 ? 265 PRO B O 1 ATOM 6383 C CB . PRO B 1 265 ? 25.047 2.434 38.484 1.00 36.52 ? 265 PRO B CB 1 ATOM 6384 C CG . PRO B 1 265 ? 24.376 1.140 38.509 1.00 40.84 ? 265 PRO B CG 1 ATOM 6385 C CD . PRO B 1 265 ? 22.912 1.442 38.575 1.00 37.18 ? 265 PRO B CD 1 ATOM 6386 N N . LEU B 1 266 ? 25.264 4.323 35.782 1.00 36.25 ? 266 LEU B N 1 ATOM 6387 C CA . LEU B 1 266 ? 25.686 4.532 34.402 1.00 35.68 ? 266 LEU B CA 1 ATOM 6388 C C . LEU B 1 266 ? 27.137 4.161 34.233 1.00 39.80 ? 266 LEU B C 1 ATOM 6389 O O . LEU B 1 266 ? 27.986 4.716 34.924 1.00 40.14 ? 266 LEU B O 1 ATOM 6390 C CB . LEU B 1 266 ? 25.443 5.998 34.010 1.00 35.38 ? 266 LEU B CB 1 ATOM 6391 C CG . LEU B 1 266 ? 23.993 6.475 34.096 1.00 39.51 ? 266 LEU B CG 1 ATOM 6392 C CD1 . LEU B 1 266 ? 23.915 7.968 34.306 1.00 39.29 ? 266 LEU B CD1 1 ATOM 6393 C CD2 . LEU B 1 266 ? 23.224 6.066 32.881 1.00 41.83 ? 266 LEU B CD2 1 ATOM 6394 N N . THR B 1 267 ? 27.424 3.214 33.329 1.00 37.00 ? 267 THR B N 1 ATOM 6395 C CA . THR B 1 267 ? 28.780 2.724 33.058 1.00 37.31 ? 267 THR B CA 1 ATOM 6396 C C . THR B 1 267 ? 29.242 3.063 31.634 1.00 44.84 ? 267 THR B C 1 ATOM 6397 O O . THR B 1 267 ? 28.477 2.879 30.689 1.00 44.69 ? 267 THR B O 1 ATOM 6398 C CB . THR B 1 267 ? 28.855 1.216 33.389 1.00 36.68 ? 267 THR B CB 1 ATOM 6399 O OG1 . THR B 1 267 ? 28.504 1.041 34.759 1.00 41.98 ? 267 THR B OG1 1 ATOM 6400 C CG2 . THR B 1 267 ? 30.223 0.605 33.142 1.00 26.46 ? 267 THR B CG2 1 ATOM 6401 N N . ASN B 1 268 ? 30.492 3.547 31.476 1.00 43.50 ? 268 ASN B N 1 ATOM 6402 C CA . ASN B 1 268 ? 31.030 3.835 30.144 1.00 44.02 ? 268 ASN B CA 1 ATOM 6403 C C . ASN B 1 268 ? 31.523 2.545 29.475 1.00 50.31 ? 268 ASN B C 1 ATOM 6404 O O . ASN B 1 268 ? 31.571 1.499 30.128 1.00 51.04 ? 268 ASN B O 1 ATOM 6405 C CB . ASN B 1 268 ? 32.133 4.911 30.196 1.00 42.84 ? 268 ASN B CB 1 ATOM 6406 C CG . ASN B 1 268 ? 33.341 4.625 31.060 1.00 62.88 ? 268 ASN B CG 1 ATOM 6407 O OD1 . ASN B 1 268 ? 33.751 3.477 31.286 1.00 60.04 ? 268 ASN B OD1 1 ATOM 6408 N ND2 . ASN B 1 268 ? 33.992 5.691 31.501 1.00 48.81 ? 268 ASN B ND2 1 ATOM 6409 N N . SER B 1 269 ? 31.908 2.608 28.187 1.00 47.25 ? 269 SER B N 1 ATOM 6410 C CA . SER B 1 269 ? 32.428 1.431 27.472 1.00 46.69 ? 269 SER B CA 1 ATOM 6411 C C . SER B 1 269 ? 33.691 0.861 28.135 1.00 48.91 ? 269 SER B C 1 ATOM 6412 O O . SER B 1 269 ? 33.884 -0.353 28.129 1.00 48.49 ? 269 SER B O 1 ATOM 6413 C CB . SER B 1 269 ? 32.702 1.754 26.004 1.00 50.04 ? 269 SER B CB 1 ATOM 6414 O OG . SER B 1 269 ? 33.599 2.839 25.850 1.00 55.04 ? 269 SER B OG 1 ATOM 6415 N N . LYS B 1 270 ? 34.510 1.735 28.748 1.00 44.17 ? 270 LYS B N 1 ATOM 6416 C CA . LYS B 1 270 ? 35.758 1.381 29.421 1.00 43.16 ? 270 LYS B CA 1 ATOM 6417 C C . LYS B 1 270 ? 35.568 0.791 30.860 1.00 46.24 ? 270 LYS B C 1 ATOM 6418 O O . LYS B 1 270 ? 36.557 0.489 31.527 1.00 45.77 ? 270 LYS B O 1 ATOM 6419 C CB . LYS B 1 270 ? 36.713 2.578 29.403 1.00 45.10 ? 270 LYS B CB 1 ATOM 6420 C CG . LYS B 1 270 ? 37.322 2.839 28.029 1.00 61.88 ? 270 LYS B CG 1 ATOM 6421 C CD . LYS B 1 270 ? 38.241 4.059 28.041 1.00 75.53 ? 270 LYS B CD 1 ATOM 6422 C CE . LYS B 1 270 ? 38.571 4.563 26.656 1.00 90.15 ? 270 LYS B CE 1 ATOM 6423 N NZ . LYS B 1 270 ? 39.473 5.746 26.706 1.00 97.26 ? 270 LYS B NZ 1 ATOM 6424 N N . GLY B 1 271 ? 34.313 0.588 31.286 1.00 41.58 ? 271 GLY B N 1 ATOM 6425 C CA . GLY B 1 271 ? 33.958 -0.042 32.558 1.00 39.99 ? 271 GLY B CA 1 ATOM 6426 C C . GLY B 1 271 ? 33.935 0.791 33.829 1.00 41.92 ? 271 GLY B C 1 ATOM 6427 O O . GLY B 1 271 ? 33.859 0.227 34.920 1.00 40.17 ? 271 GLY B O 1 ATOM 6428 N N . GLN B 1 272 ? 33.991 2.122 33.719 1.00 39.22 ? 272 GLN B N 1 ATOM 6429 C CA . GLN B 1 272 ? 33.973 3.031 34.876 1.00 39.37 ? 272 GLN B CA 1 ATOM 6430 C C . GLN B 1 272 ? 32.562 3.436 35.260 1.00 43.82 ? 272 GLN B C 1 ATOM 6431 O O . GLN B 1 272 ? 31.654 3.311 34.446 1.00 46.14 ? 272 GLN B O 1 ATOM 6432 C CB . GLN B 1 272 ? 34.745 4.318 34.542 1.00 40.74 ? 272 GLN B CB 1 ATOM 6433 C CG . GLN B 1 272 ? 36.242 4.206 34.729 1.00 60.53 ? 272 GLN B CG 1 ATOM 6434 C CD . GLN B 1 272 ? 36.991 5.280 33.988 1.00 81.71 ? 272 GLN B CD 1 ATOM 6435 O OE1 . GLN B 1 272 ? 36.701 5.605 32.832 1.00 75.73 ? 272 GLN B OE1 1 ATOM 6436 N NE2 . GLN B 1 272 ? 38.027 5.798 34.613 1.00 80.58 ? 272 GLN B NE2 1 ATOM 6437 N N . ASN B 1 273 ? 32.382 4.008 36.451 1.00 38.16 ? 273 ASN B N 1 ATOM 6438 C CA . ASN B 1 273 ? 31.080 4.537 36.816 1.00 37.45 ? 273 ASN B CA 1 ATOM 6439 C C . ASN B 1 273 ? 31.063 6.016 36.434 1.00 41.28 ? 273 ASN B C 1 ATOM 6440 O O . ASN B 1 273 ? 31.923 6.769 36.890 1.00 39.62 ? 273 ASN B O 1 ATOM 6441 C CB . ASN B 1 273 ? 30.784 4.356 38.304 1.00 37.46 ? 273 ASN B CB 1 ATOM 6442 C CG . ASN B 1 273 ? 29.325 4.534 38.629 1.00 64.11 ? 273 ASN B CG 1 ATOM 6443 O OD1 . ASN B 1 273 ? 28.445 3.907 38.022 1.00 58.03 ? 273 ASN B OD1 1 ATOM 6444 N ND2 . ASN B 1 273 ? 29.034 5.394 39.592 1.00 58.06 ? 273 ASN B ND2 1 ATOM 6445 N N . CYS B 1 274 ? 30.113 6.416 35.569 1.00 39.13 ? 274 CYS B N 1 ATOM 6446 C CA . CYS B 1 274 ? 29.936 7.797 35.112 1.00 40.39 ? 274 CYS B CA 1 ATOM 6447 C C . CYS B 1 274 ? 29.012 8.545 36.044 1.00 44.16 ? 274 CYS B C 1 ATOM 6448 O O . CYS B 1 274 ? 29.114 9.774 36.177 1.00 43.34 ? 274 CYS B O 1 ATOM 6449 C CB . CYS B 1 274 ? 29.402 7.835 33.685 1.00 41.93 ? 274 CYS B CB 1 ATOM 6450 S SG . CYS B 1 274 ? 30.607 7.339 32.438 1.00 46.65 ? 274 CYS B SG 1 ATOM 6451 N N . GLY B 1 275 ? 28.082 7.802 36.639 1.00 39.74 ? 275 GLY B N 1 ATOM 6452 C CA . GLY B 1 275 ? 27.111 8.360 37.562 1.00 38.09 ? 275 GLY B CA 1 ATOM 6453 C C . GLY B 1 275 ? 25.899 7.494 37.757 1.00 39.28 ? 275 GLY B C 1 ATOM 6454 O O . GLY B 1 275 ? 25.973 6.266 37.649 1.00 37.57 ? 275 GLY B O 1 ATOM 6455 N N . TYR B 1 276 ? 24.776 8.155 38.062 1.00 35.72 ? 276 TYR B N 1 ATOM 6456 C CA . TYR B 1 276 ? 23.484 7.541 38.353 1.00 34.87 ? 276 TYR B CA 1 ATOM 6457 C C . TYR B 1 276 ? 22.358 8.273 37.632 1.00 39.95 ? 276 TYR B C 1 ATOM 6458 O O . TYR B 1 276 ? 22.275 9.507 37.695 1.00 40.43 ? 276 TYR B O 1 ATOM 6459 C CB . TYR B 1 276 ? 23.232 7.547 39.874 1.00 34.80 ? 276 TYR B CB 1 ATOM 6460 C CG . TYR B 1 276 ? 22.219 6.523 40.325 1.00 35.98 ? 276 TYR B CG 1 ATOM 6461 C CD1 . TYR B 1 276 ? 22.586 5.196 40.545 1.00 36.40 ? 276 TYR B CD1 1 ATOM 6462 C CD2 . TYR B 1 276 ? 20.891 6.874 40.531 1.00 37.57 ? 276 TYR B CD2 1 ATOM 6463 C CE1 . TYR B 1 276 ? 21.651 4.244 40.942 1.00 34.43 ? 276 TYR B CE1 1 ATOM 6464 C CE2 . TYR B 1 276 ? 19.947 5.929 40.935 1.00 38.30 ? 276 TYR B CE2 1 ATOM 6465 C CZ . TYR B 1 276 ? 20.330 4.614 41.121 1.00 41.30 ? 276 TYR B CZ 1 ATOM 6466 O OH . TYR B 1 276 ? 19.388 3.697 41.498 1.00 43.38 ? 276 TYR B OH 1 ATOM 6467 N N . ARG B 1 277 ? 21.512 7.491 36.929 1.00 35.61 ? 277 ARG B N 1 ATOM 6468 C CA . ARG B 1 277 ? 20.316 7.922 36.202 1.00 34.61 ? 277 ARG B CA 1 ATOM 6469 C C . ARG B 1 277 ? 19.096 7.802 37.147 1.00 39.47 ? 277 ARG B C 1 ATOM 6470 O O . ARG B 1 277 ? 18.976 6.820 37.885 1.00 39.57 ? 277 ARG B O 1 ATOM 6471 C CB . ARG B 1 277 ? 20.129 7.028 34.957 1.00 30.14 ? 277 ARG B CB 1 ATOM 6472 C CG . ARG B 1 277 ? 18.755 7.091 34.290 1.00 26.90 ? 277 ARG B CG 1 ATOM 6473 C CD . ARG B 1 277 ? 18.666 6.312 32.983 1.00 20.28 ? 277 ARG B CD 1 ATOM 6474 N NE . ARG B 1 277 ? 18.856 4.878 33.180 1.00 29.25 ? 277 ARG B NE 1 ATOM 6475 C CZ . ARG B 1 277 ? 17.910 4.029 33.572 1.00 47.08 ? 277 ARG B CZ 1 ATOM 6476 N NH1 . ARG B 1 277 ? 16.675 4.456 33.795 1.00 36.73 ? 277 ARG B NH1 1 ATOM 6477 N NH2 . ARG B 1 277 ? 18.182 2.744 33.710 1.00 40.40 ? 277 ARG B NH2 1 ATOM 6478 N N . ARG B 1 278 ? 18.201 8.794 37.119 1.00 35.56 ? 278 ARG B N 1 ATOM 6479 C CA . ARG B 1 278 ? 16.961 8.790 37.919 1.00 35.02 ? 278 ARG B CA 1 ATOM 6480 C C . ARG B 1 278 ? 15.720 9.135 37.034 1.00 38.81 ? 278 ARG B C 1 ATOM 6481 O O . ARG B 1 278 ? 14.626 9.425 37.540 1.00 37.51 ? 278 ARG B O 1 ATOM 6482 C CB . ARG B 1 278 ? 17.088 9.718 39.143 1.00 31.74 ? 278 ARG B CB 1 ATOM 6483 C CG . ARG B 1 278 ? 18.124 9.253 40.142 1.00 33.37 ? 278 ARG B CG 1 ATOM 6484 C CD . ARG B 1 278 ? 18.000 10.063 41.393 1.00 49.09 ? 278 ARG B CD 1 ATOM 6485 N NE . ARG B 1 278 ? 19.247 10.106 42.155 1.00 60.64 ? 278 ARG B NE 1 ATOM 6486 C CZ . ARG B 1 278 ? 20.171 11.055 42.033 1.00 74.01 ? 278 ARG B CZ 1 ATOM 6487 N NH1 . ARG B 1 278 ? 20.018 12.033 41.147 1.00 51.23 ? 278 ARG B NH1 1 ATOM 6488 N NH2 . ARG B 1 278 ? 21.260 11.025 42.785 1.00 69.95 ? 278 ARG B NH2 1 ATOM 6489 N N . CYS B 1 279 ? 15.911 9.045 35.699 1.00 35.19 ? 279 CYS B N 1 ATOM 6490 C CA . CYS B 1 279 ? 14.913 9.332 34.677 1.00 34.83 ? 279 CYS B CA 1 ATOM 6491 C C . CYS B 1 279 ? 14.833 8.173 33.670 1.00 39.57 ? 279 CYS B C 1 ATOM 6492 O O . CYS B 1 279 ? 15.359 7.098 33.951 1.00 39.33 ? 279 CYS B O 1 ATOM 6493 C CB . CYS B 1 279 ? 15.222 10.666 33.996 1.00 34.96 ? 279 CYS B CB 1 ATOM 6494 S SG . CYS B 1 279 ? 16.860 10.748 33.221 1.00 38.51 ? 279 CYS B SG 1 ATOM 6495 N N . ARG B 1 280 ? 14.162 8.386 32.518 1.00 36.38 ? 280 ARG B N 1 ATOM 6496 C CA . ARG B 1 280 ? 14.004 7.408 31.442 1.00 36.30 ? 280 ARG B CA 1 ATOM 6497 C C . ARG B 1 280 ? 15.339 6.998 30.773 1.00 41.14 ? 280 ARG B C 1 ATOM 6498 O O . ARG B 1 280 ? 16.145 7.871 30.413 1.00 42.60 ? 280 ARG B O 1 ATOM 6499 C CB . ARG B 1 280 ? 13.035 7.968 30.372 1.00 34.65 ? 280 ARG B CB 1 ATOM 6500 C CG . ARG B 1 280 ? 13.001 7.173 29.048 1.00 39.15 ? 280 ARG B CG 1 ATOM 6501 C CD . ARG B 1 280 ? 11.964 6.059 29.037 1.00 40.28 ? 280 ARG B CD 1 ATOM 6502 N NE . ARG B 1 280 ? 10.632 6.636 29.163 1.00 36.13 ? 280 ARG B NE 1 ATOM 6503 C CZ . ARG B 1 280 ? 9.700 6.222 30.006 1.00 51.45 ? 280 ARG B CZ 1 ATOM 6504 N NH1 . ARG B 1 280 ? 9.915 5.163 30.780 1.00 29.17 ? 280 ARG B NH1 1 ATOM 6505 N NH2 . ARG B 1 280 ? 8.533 6.851 30.069 1.00 44.84 ? 280 ARG B NH2 1 ATOM 6506 N N . ALA B 1 281 ? 15.537 5.678 30.567 1.00 35.50 ? 281 ALA B N 1 ATOM 6507 C CA . ALA B 1 281 ? 16.691 5.136 29.845 1.00 34.89 ? 281 ALA B CA 1 ATOM 6508 C C . ALA B 1 281 ? 16.298 5.180 28.382 1.00 40.56 ? 281 ALA B C 1 ATOM 6509 O O . ALA B 1 281 ? 15.211 4.723 28.030 1.00 41.70 ? 281 ALA B O 1 ATOM 6510 C CB . ALA B 1 281 ? 16.961 3.698 30.268 1.00 35.22 ? 281 ALA B CB 1 ATOM 6511 N N . SER B 1 282 ? 17.135 5.772 27.535 1.00 37.27 ? 282 SER B N 1 ATOM 6512 C CA . SER B 1 282 ? 16.871 5.895 26.089 1.00 36.77 ? 282 SER B CA 1 ATOM 6513 C C . SER B 1 282 ? 16.862 4.543 25.311 1.00 38.64 ? 282 SER B C 1 ATOM 6514 O O . SER B 1 282 ? 16.165 4.419 24.303 1.00 37.62 ? 282 SER B O 1 ATOM 6515 C CB . SER B 1 282 ? 17.848 6.882 25.454 1.00 41.53 ? 282 SER B CB 1 ATOM 6516 O OG . SER B 1 282 ? 19.096 6.945 26.132 1.00 50.84 ? 282 SER B OG 1 ATOM 6517 N N . GLY B 1 283 ? 17.605 3.557 25.808 1.00 34.53 ? 283 GLY B N 1 ATOM 6518 C CA . GLY B 1 283 ? 17.720 2.243 25.199 1.00 33.95 ? 283 GLY B CA 1 ATOM 6519 C C . GLY B 1 283 ? 17.072 1.075 25.926 1.00 38.44 ? 283 GLY B C 1 ATOM 6520 O O . GLY B 1 283 ? 17.684 0.000 26.010 1.00 39.36 ? 283 GLY B O 1 ATOM 6521 N N . VAL B 1 284 ? 15.806 1.246 26.405 1.00 32.80 ? 284 VAL B N 1 ATOM 6522 C CA . VAL B 1 284 ? 15.004 0.169 27.024 1.00 31.09 ? 284 VAL B CA 1 ATOM 6523 C C . VAL B 1 284 ? 13.758 -0.130 26.169 1.00 33.47 ? 284 VAL B C 1 ATOM 6524 O O . VAL B 1 284 ? 13.310 0.747 25.424 1.00 32.30 ? 284 VAL B O 1 ATOM 6525 C CB . VAL B 1 284 ? 14.664 0.337 28.534 1.00 34.13 ? 284 VAL B CB 1 ATOM 6526 C CG1 . VAL B 1 284 ? 15.917 0.225 29.404 1.00 33.29 ? 284 VAL B CG1 1 ATOM 6527 C CG2 . VAL B 1 284 ? 13.880 1.622 28.825 1.00 33.70 ? 284 VAL B CG2 1 ATOM 6528 N N . LEU B 1 285 ? 13.216 -1.370 26.263 1.00 30.39 ? 285 LEU B N 1 ATOM 6529 C CA . LEU B 1 285 ? 12.040 -1.823 25.506 1.00 30.28 ? 285 LEU B CA 1 ATOM 6530 C C . LEU B 1 285 ? 10.830 -0.912 25.667 1.00 34.45 ? 285 LEU B C 1 ATOM 6531 O O . LEU B 1 285 ? 10.156 -0.617 24.676 1.00 33.65 ? 285 LEU B O 1 ATOM 6532 C CB . LEU B 1 285 ? 11.666 -3.294 25.820 1.00 30.48 ? 285 LEU B CB 1 ATOM 6533 C CG . LEU B 1 285 ? 10.518 -3.898 24.968 1.00 34.48 ? 285 LEU B CG 1 ATOM 6534 C CD1 . LEU B 1 285 ? 10.942 -4.143 23.545 1.00 33.89 ? 285 LEU B CD1 1 ATOM 6535 C CD2 . LEU B 1 285 ? 10.005 -5.160 25.561 1.00 36.41 ? 285 LEU B CD2 1 ATOM 6536 N N . THR B 1 286 ? 10.577 -0.461 26.912 1.00 31.69 ? 286 THR B N 1 ATOM 6537 C CA . THR B 1 286 ? 9.465 0.413 27.290 1.00 31.49 ? 286 THR B CA 1 ATOM 6538 C C . THR B 1 286 ? 9.697 1.922 27.052 1.00 38.56 ? 286 THR B C 1 ATOM 6539 O O . THR B 1 286 ? 8.851 2.704 27.481 1.00 39.46 ? 286 THR B O 1 ATOM 6540 C CB . THR B 1 286 ? 9.083 0.165 28.747 1.00 33.96 ? 286 THR B CB 1 ATOM 6541 O OG1 . THR B 1 286 ? 10.232 0.380 29.553 1.00 32.24 ? 286 THR B OG1 1 ATOM 6542 C CG2 . THR B 1 286 ? 8.511 -1.210 28.984 1.00 31.17 ? 286 THR B CG2 1 ATOM 6543 N N . THR B 1 287 ? 10.808 2.345 26.376 1.00 35.98 ? 287 THR B N 1 ATOM 6544 C CA . THR B 1 287 ? 11.082 3.776 26.107 1.00 35.71 ? 287 THR B CA 1 ATOM 6545 C C . THR B 1 287 ? 9.968 4.414 25.265 1.00 39.75 ? 287 THR B C 1 ATOM 6546 O O . THR B 1 287 ? 9.437 5.449 25.653 1.00 38.83 ? 287 THR B O 1 ATOM 6547 C CB . THR B 1 287 ? 12.490 3.992 25.500 1.00 41.25 ? 287 THR B CB 1 ATOM 6548 O OG1 . THR B 1 287 ? 13.464 3.512 26.420 1.00 41.93 ? 287 THR B OG1 1 ATOM 6549 C CG2 . THR B 1 287 ? 12.784 5.465 25.154 1.00 31.98 ? 287 THR B CG2 1 ATOM 6550 N N . SER B 1 288 ? 9.606 3.787 24.141 1.00 37.10 ? 288 SER B N 1 ATOM 6551 C CA . SER B 1 288 ? 8.564 4.290 23.253 1.00 37.03 ? 288 SER B CA 1 ATOM 6552 C C . SER B 1 288 ? 7.216 4.309 23.934 1.00 39.20 ? 288 SER B C 1 ATOM 6553 O O . SER B 1 288 ? 6.645 5.383 24.080 1.00 36.29 ? 288 SER B O 1 ATOM 6554 C CB . SER B 1 288 ? 8.509 3.474 21.969 1.00 41.16 ? 288 SER B CB 1 ATOM 6555 O OG . SER B 1 288 ? 8.208 4.320 20.873 1.00 53.42 ? 288 SER B OG 1 ATOM 6556 N N . CYS B 1 289 ? 6.754 3.132 24.414 1.00 37.68 ? 289 CYS B N 1 ATOM 6557 C CA . CYS B 1 289 ? 5.474 2.913 25.091 1.00 38.42 ? 289 CYS B CA 1 ATOM 6558 C C . CYS B 1 289 ? 5.310 3.801 26.332 1.00 41.05 ? 289 CYS B C 1 ATOM 6559 O O . CYS B 1 289 ? 4.322 4.543 26.423 1.00 40.55 ? 289 CYS B O 1 ATOM 6560 C CB . CYS B 1 289 ? 5.299 1.435 25.418 1.00 39.73 ? 289 CYS B CB 1 ATOM 6561 S SG . CYS B 1 289 ? 3.735 1.021 26.240 1.00 44.19 ? 289 CYS B SG 1 ATOM 6562 N N . GLY B 1 290 ? 6.299 3.751 27.234 1.00 35.38 ? 290 GLY B N 1 ATOM 6563 C CA . GLY B 1 290 ? 6.341 4.573 28.436 1.00 33.66 ? 290 GLY B CA 1 ATOM 6564 C C . GLY B 1 290 ? 6.195 6.047 28.116 1.00 35.04 ? 290 GLY B C 1 ATOM 6565 O O . GLY B 1 290 ? 5.332 6.728 28.687 1.00 35.64 ? 290 GLY B O 1 ATOM 6566 N N . ASN B 1 291 ? 7.014 6.542 27.173 1.00 28.59 ? 291 ASN B N 1 ATOM 6567 C CA . ASN B 1 291 ? 6.969 7.939 26.736 1.00 27.86 ? 291 ASN B CA 1 ATOM 6568 C C . ASN B 1 291 ? 5.614 8.332 26.181 1.00 29.82 ? 291 ASN B C 1 ATOM 6569 O O . ASN B 1 291 ? 5.161 9.423 26.498 1.00 28.03 ? 291 ASN B O 1 ATOM 6570 C CB . ASN B 1 291 ? 8.085 8.263 25.726 1.00 28.47 ? 291 ASN B CB 1 ATOM 6571 C CG . ASN B 1 291 ? 9.459 8.535 26.323 1.00 40.95 ? 291 ASN B CG 1 ATOM 6572 O OD1 . ASN B 1 291 ? 9.645 8.646 27.540 1.00 34.40 ? 291 ASN B OD1 1 ATOM 6573 N ND2 . ASN B 1 291 ? 10.455 8.705 25.468 1.00 27.44 ? 291 ASN B ND2 1 ATOM 6574 N N . THR B 1 292 ? 4.961 7.444 25.377 1.00 28.08 ? 292 THR B N 1 ATOM 6575 C CA . THR B 1 292 ? 3.640 7.685 24.759 1.00 28.71 ? 292 THR B CA 1 ATOM 6576 C C . THR B 1 292 ? 2.571 7.770 25.843 1.00 33.97 ? 292 THR B C 1 ATOM 6577 O O . THR B 1 292 ? 1.734 8.676 25.811 1.00 33.11 ? 292 THR B O 1 ATOM 6578 C CB . THR B 1 292 ? 3.270 6.600 23.722 1.00 41.49 ? 292 THR B CB 1 ATOM 6579 O OG1 . THR B 1 292 ? 4.396 6.240 22.932 1.00 50.52 ? 292 THR B OG1 1 ATOM 6580 C CG2 . THR B 1 292 ? 2.202 7.051 22.782 1.00 38.49 ? 292 THR B CG2 1 ATOM 6581 N N . LEU B 1 293 ? 2.608 6.834 26.809 1.00 30.89 ? 293 LEU B N 1 ATOM 6582 C CA . LEU B 1 293 ? 1.654 6.840 27.912 1.00 30.40 ? 293 LEU B CA 1 ATOM 6583 C C . LEU B 1 293 ? 1.824 8.102 28.766 1.00 32.88 ? 293 LEU B C 1 ATOM 6584 O O . LEU B 1 293 ? 0.842 8.809 28.986 1.00 31.76 ? 293 LEU B O 1 ATOM 6585 C CB . LEU B 1 293 ? 1.788 5.575 28.785 1.00 30.32 ? 293 LEU B CB 1 ATOM 6586 C CG . LEU B 1 293 ? 1.499 4.222 28.148 1.00 34.16 ? 293 LEU B CG 1 ATOM 6587 C CD1 . LEU B 1 293 ? 1.939 3.120 29.076 1.00 34.47 ? 293 LEU B CD1 1 ATOM 6588 C CD2 . LEU B 1 293 ? 0.005 4.063 27.801 1.00 34.58 ? 293 LEU B CD2 1 ATOM 6589 N N . THR B 1 294 ? 3.066 8.403 29.209 1.00 28.93 ? 294 THR B N 1 ATOM 6590 C CA . THR B 1 294 ? 3.345 9.561 30.054 1.00 29.61 ? 294 THR B CA 1 ATOM 6591 C C . THR B 1 294 ? 3.036 10.899 29.308 1.00 35.67 ? 294 THR B C 1 ATOM 6592 O O . THR B 1 294 ? 2.528 11.832 29.939 1.00 36.62 ? 294 THR B O 1 ATOM 6593 C CB . THR B 1 294 ? 4.764 9.439 30.640 1.00 38.41 ? 294 THR B CB 1 ATOM 6594 O OG1 . THR B 1 294 ? 4.794 8.250 31.432 1.00 43.76 ? 294 THR B OG1 1 ATOM 6595 C CG2 . THR B 1 294 ? 5.160 10.613 31.528 1.00 31.41 ? 294 THR B CG2 1 ATOM 6596 N N . CYS B 1 295 ? 3.264 10.971 27.984 1.00 31.54 ? 295 CYS B N 1 ATOM 6597 C CA . CYS B 1 295 ? 2.948 12.192 27.247 1.00 31.40 ? 295 CYS B CA 1 ATOM 6598 C C . CYS B 1 295 ? 1.451 12.390 27.139 1.00 33.98 ? 295 CYS B C 1 ATOM 6599 O O . CYS B 1 295 ? 0.965 13.473 27.467 1.00 34.36 ? 295 CYS B O 1 ATOM 6600 C CB . CYS B 1 295 ? 3.632 12.247 25.884 1.00 32.21 ? 295 CYS B CB 1 ATOM 6601 S SG . CYS B 1 295 ? 3.302 13.778 24.974 1.00 36.44 ? 295 CYS B SG 1 ATOM 6602 N N . TYR B 1 296 ? 0.717 11.340 26.723 1.00 29.74 ? 296 TYR B N 1 ATOM 6603 C CA . TYR B 1 296 ? -0.751 11.344 26.627 1.00 28.65 ? 296 TYR B CA 1 ATOM 6604 C C . TYR B 1 296 ? -1.401 11.619 27.987 1.00 31.73 ? 296 TYR B C 1 ATOM 6605 O O . TYR B 1 296 ? -2.349 12.393 28.034 1.00 31.71 ? 296 TYR B O 1 ATOM 6606 C CB . TYR B 1 296 ? -1.244 10.011 26.069 1.00 29.04 ? 296 TYR B CB 1 ATOM 6607 C CG . TYR B 1 296 ? -2.738 9.785 26.128 1.00 29.10 ? 296 TYR B CG 1 ATOM 6608 C CD1 . TYR B 1 296 ? -3.554 10.116 25.052 1.00 30.96 ? 296 TYR B CD1 1 ATOM 6609 C CD2 . TYR B 1 296 ? -3.314 9.103 27.191 1.00 29.45 ? 296 TYR B CD2 1 ATOM 6610 C CE1 . TYR B 1 296 ? -4.916 9.830 25.059 1.00 31.71 ? 296 TYR B CE1 1 ATOM 6611 C CE2 . TYR B 1 296 ? -4.675 8.818 27.214 1.00 31.22 ? 296 TYR B CE2 1 ATOM 6612 C CZ . TYR B 1 296 ? -5.476 9.188 26.144 1.00 37.89 ? 296 TYR B CZ 1 ATOM 6613 O OH . TYR B 1 296 ? -6.818 8.909 26.156 1.00 38.73 ? 296 TYR B OH 1 ATOM 6614 N N . LEU B 1 297 ? -0.896 10.997 29.079 1.00 27.84 ? 297 LEU B N 1 ATOM 6615 C CA . LEU B 1 297 ? -1.411 11.221 30.434 1.00 29.05 ? 297 LEU B CA 1 ATOM 6616 C C . LEU B 1 297 ? -1.275 12.708 30.852 1.00 35.73 ? 297 LEU B C 1 ATOM 6617 O O . LEU B 1 297 ? -2.233 13.287 31.363 1.00 37.76 ? 297 LEU B O 1 ATOM 6618 C CB . LEU B 1 297 ? -0.745 10.274 31.465 1.00 28.97 ? 297 LEU B CB 1 ATOM 6619 C CG . LEU B 1 297 ? -1.009 10.509 32.975 1.00 33.10 ? 297 LEU B CG 1 ATOM 6620 C CD1 . LEU B 1 297 ? -2.506 10.562 33.320 1.00 34.42 ? 297 LEU B CD1 1 ATOM 6621 C CD2 . LEU B 1 297 ? -0.360 9.434 33.802 1.00 33.30 ? 297 LEU B CD2 1 ATOM 6622 N N . LYS B 1 298 ? -0.117 13.319 30.599 1.00 30.90 ? 298 LYS B N 1 ATOM 6623 C CA . LYS B 1 298 ? 0.101 14.713 30.952 1.00 30.38 ? 298 LYS B CA 1 ATOM 6624 C C . LYS B 1 298 ? -0.684 15.685 30.066 1.00 35.03 ? 298 LYS B C 1 ATOM 6625 O O . LYS B 1 298 ? -1.248 16.649 30.584 1.00 34.62 ? 298 LYS B O 1 ATOM 6626 C CB . LYS B 1 298 ? 1.604 15.039 30.974 1.00 31.91 ? 298 LYS B CB 1 ATOM 6627 C CG . LYS B 1 298 ? 2.356 14.283 32.063 1.00 26.40 ? 298 LYS B CG 1 ATOM 6628 C CD . LYS B 1 298 ? 3.833 14.560 32.065 1.00 26.84 ? 298 LYS B CD 1 ATOM 6629 C CE . LYS B 1 298 ? 4.499 13.790 33.169 1.00 28.98 ? 298 LYS B CE 1 ATOM 6630 N NZ . LYS B 1 298 ? 5.947 14.091 33.250 1.00 36.29 ? 298 LYS B NZ 1 ATOM 6631 N N . ALA B 1 299 ? -0.732 15.424 28.746 1.00 32.49 ? 299 ALA B N 1 ATOM 6632 C CA . ALA B 1 299 ? -1.411 16.278 27.768 1.00 32.72 ? 299 ALA B CA 1 ATOM 6633 C C . ALA B 1 299 ? -2.934 16.238 27.848 1.00 39.60 ? 299 ALA B C 1 ATOM 6634 O O . ALA B 1 299 ? -3.559 17.280 27.673 1.00 40.06 ? 299 ALA B O 1 ATOM 6635 C CB . ALA B 1 299 ? -0.937 15.957 26.366 1.00 33.31 ? 299 ALA B CB 1 ATOM 6636 N N . SER B 1 300 ? -3.532 15.052 28.100 1.00 37.67 ? 300 SER B N 1 ATOM 6637 C CA . SER B 1 300 ? -4.980 14.891 28.265 1.00 38.28 ? 300 SER B CA 1 ATOM 6638 C C . SER B 1 300 ? -5.434 15.676 29.510 1.00 44.01 ? 300 SER B C 1 ATOM 6639 O O . SER B 1 300 ? -6.452 16.369 29.460 1.00 44.09 ? 300 SER B O 1 ATOM 6640 C CB . SER B 1 300 ? -5.339 13.423 28.453 1.00 42.07 ? 300 SER B CB 1 ATOM 6641 O OG . SER B 1 300 ? -4.940 12.626 27.353 1.00 51.28 ? 300 SER B OG 1 ATOM 6642 N N . ALA B 1 301 ? -4.663 15.555 30.620 1.00 40.54 ? 301 ALA B N 1 ATOM 6643 C CA . ALA B 1 301 ? -4.885 16.249 31.887 1.00 40.12 ? 301 ALA B CA 1 ATOM 6644 C C . ALA B 1 301 ? -4.724 17.769 31.712 1.00 43.22 ? 301 ALA B C 1 ATOM 6645 O O . ALA B 1 301 ? -5.526 18.539 32.261 1.00 41.95 ? 301 ALA B O 1 ATOM 6646 C CB . ALA B 1 301 ? -3.909 15.736 32.923 1.00 40.80 ? 301 ALA B CB 1 ATOM 6647 N N . ALA B 1 302 ? -3.707 18.188 30.921 1.00 39.57 ? 302 ALA B N 1 ATOM 6648 C CA . ALA B 1 302 ? -3.418 19.584 30.596 1.00 39.19 ? 302 ALA B CA 1 ATOM 6649 C C . ALA B 1 302 ? -4.464 20.160 29.626 1.00 45.81 ? 302 ALA B C 1 ATOM 6650 O O . ALA B 1 302 ? -4.674 21.372 29.632 1.00 44.75 ? 302 ALA B O 1 ATOM 6651 C CB . ALA B 1 302 ? -2.026 19.710 30.010 1.00 39.46 ? 302 ALA B CB 1 ATOM 6652 N N . CYS B 1 303 ? -5.130 19.297 28.809 1.00 44.95 ? 303 CYS B N 1 ATOM 6653 C CA . CYS B 1 303 ? -6.188 19.706 27.877 1.00 46.55 ? 303 CYS B CA 1 ATOM 6654 C C . CYS B 1 303 ? -7.373 20.164 28.718 1.00 45.63 ? 303 CYS B C 1 ATOM 6655 O O . CYS B 1 303 ? -7.959 21.205 28.426 1.00 45.58 ? 303 CYS B O 1 ATOM 6656 C CB . CYS B 1 303 ? -6.587 18.564 26.939 1.00 49.32 ? 303 CYS B CB 1 ATOM 6657 S SG . CYS B 1 303 ? -6.106 18.802 25.209 1.00 55.18 ? 303 CYS B SG 1 ATOM 6658 N N . ARG B 1 304 ? -7.701 19.383 29.774 1.00 38.78 ? 304 ARG B N 1 ATOM 6659 C CA . ARG B 1 304 ? -8.790 19.610 30.722 1.00 37.13 ? 304 ARG B CA 1 ATOM 6660 C C . ARG B 1 304 ? -8.510 20.828 31.569 1.00 43.31 ? 304 ARG B C 1 ATOM 6661 O O . ARG B 1 304 ? -9.419 21.628 31.801 1.00 43.76 ? 304 ARG B O 1 ATOM 6662 C CB . ARG B 1 304 ? -8.995 18.387 31.607 1.00 33.54 ? 304 ARG B CB 1 ATOM 6663 C CG . ARG B 1 304 ? -9.277 17.130 30.808 1.00 41.38 ? 304 ARG B CG 1 ATOM 6664 C CD . ARG B 1 304 ? -9.632 15.954 31.689 1.00 41.55 ? 304 ARG B CD 1 ATOM 6665 N NE . ARG B 1 304 ? -9.962 14.787 30.878 1.00 34.83 ? 304 ARG B NE 1 ATOM 6666 C CZ . ARG B 1 304 ? -10.553 13.693 31.340 1.00 40.79 ? 304 ARG B CZ 1 ATOM 6667 N NH1 . ARG B 1 304 ? -10.910 13.609 32.624 1.00 24.55 ? 304 ARG B NH1 1 ATOM 6668 N NH2 . ARG B 1 304 ? -10.804 12.678 30.526 1.00 19.11 ? 304 ARG B NH2 1 ATOM 6669 N N . ALA B 1 305 ? -7.246 20.986 32.007 1.00 41.73 ? 305 ALA B N 1 ATOM 6670 C CA . ALA B 1 305 ? -6.787 22.134 32.792 1.00 42.78 ? 305 ALA B CA 1 ATOM 6671 C C . ALA B 1 305 ? -6.977 23.437 32.013 1.00 48.51 ? 305 ALA B C 1 ATOM 6672 O O . ALA B 1 305 ? -7.365 24.439 32.610 1.00 49.28 ? 305 ALA B O 1 ATOM 6673 C CB . ALA B 1 305 ? -5.323 21.965 33.164 1.00 43.59 ? 305 ALA B CB 1 ATOM 6674 N N . ALA B 1 306 ? -6.730 23.405 30.685 1.00 44.78 ? 306 ALA B N 1 ATOM 6675 C CA . ALA B 1 306 ? -6.838 24.533 29.754 1.00 44.20 ? 306 ALA B CA 1 ATOM 6676 C C . ALA B 1 306 ? -8.260 24.820 29.274 1.00 46.82 ? 306 ALA B C 1 ATOM 6677 O O . ALA B 1 306 ? -8.486 25.887 28.693 1.00 46.42 ? 306 ALA B O 1 ATOM 6678 C CB . ALA B 1 306 ? -5.925 24.303 28.555 1.00 44.98 ? 306 ALA B CB 1 ATOM 6679 N N . LYS B 1 307 ? -9.209 23.875 29.510 1.00 42.42 ? 307 LYS B N 1 ATOM 6680 C CA . LYS B 1 307 ? -10.620 23.926 29.077 1.00 41.73 ? 307 LYS B CA 1 ATOM 6681 C C . LYS B 1 307 ? -10.732 23.933 27.527 1.00 44.79 ? 307 LYS B C 1 ATOM 6682 O O . LYS B 1 307 ? -11.605 24.572 26.933 1.00 44.61 ? 307 LYS B O 1 ATOM 6683 C CB . LYS B 1 307 ? -11.409 25.077 29.734 1.00 43.59 ? 307 LYS B CB 1 ATOM 6684 C CG . LYS B 1 307 ? -11.488 25.023 31.252 1.00 60.73 ? 307 LYS B CG 1 ATOM 6685 C CD . LYS B 1 307 ? -12.623 25.933 31.780 1.00 74.27 ? 307 LYS B CD 1 ATOM 6686 C CE . LYS B 1 307 ? -12.224 27.320 32.291 1.00 89.97 ? 307 LYS B CE 1 ATOM 6687 N NZ . LYS B 1 307 ? -12.874 28.425 31.520 1.00 96.85 ? 307 LYS B NZ 1 ATOM 6688 N N . LEU B 1 308 ? -9.827 23.195 26.892 1.00 40.08 ? 308 LEU B N 1 ATOM 6689 C CA . LEU B 1 308 ? -9.735 23.024 25.453 1.00 39.23 ? 308 LEU B CA 1 ATOM 6690 C C . LEU B 1 308 ? -10.923 22.172 25.013 1.00 45.80 ? 308 LEU B C 1 ATOM 6691 O O . LEU B 1 308 ? -11.105 21.068 25.534 1.00 46.67 ? 308 LEU B O 1 ATOM 6692 C CB . LEU B 1 308 ? -8.408 22.302 25.173 1.00 38.51 ? 308 LEU B CB 1 ATOM 6693 C CG . LEU B 1 308 ? -7.318 22.981 24.344 1.00 41.65 ? 308 LEU B CG 1 ATOM 6694 C CD1 . LEU B 1 308 ? -7.344 24.473 24.444 1.00 39.67 ? 308 LEU B CD1 1 ATOM 6695 C CD2 . LEU B 1 308 ? -5.954 22.426 24.699 1.00 43.63 ? 308 LEU B CD2 1 ATOM 6696 N N . GLN B 1 309 ? -11.757 22.701 24.099 1.00 43.93 ? 309 GLN B N 1 ATOM 6697 C CA . GLN B 1 309 ? -12.973 22.023 23.619 1.00 44.73 ? 309 GLN B CA 1 ATOM 6698 C C . GLN B 1 309 ? -12.711 21.042 22.481 1.00 51.10 ? 309 GLN B C 1 ATOM 6699 O O . GLN B 1 309 ? -12.137 21.422 21.457 1.00 50.91 ? 309 GLN B O 1 ATOM 6700 C CB . GLN B 1 309 ? -14.089 23.030 23.236 1.00 46.02 ? 309 GLN B CB 1 ATOM 6701 C CG . GLN B 1 309 ? -14.510 24.022 24.351 1.00 61.63 ? 309 GLN B CG 1 ATOM 6702 C CD . GLN B 1 309 ? -15.169 23.392 25.567 1.00 79.16 ? 309 GLN B CD 1 ATOM 6703 O OE1 . GLN B 1 309 ? -16.077 22.559 25.458 1.00 78.70 ? 309 GLN B OE1 1 ATOM 6704 N NE2 . GLN B 1 309 ? -14.746 23.805 26.757 1.00 62.49 ? 309 GLN B NE2 1 ATOM 6705 N N . ASP B 1 310 ? -13.162 19.778 22.668 1.00 48.84 ? 310 ASP B N 1 ATOM 6706 C CA . ASP B 1 310 ? -13.052 18.664 21.718 1.00 49.68 ? 310 ASP B CA 1 ATOM 6707 C C . ASP B 1 310 ? -11.595 18.339 21.327 1.00 54.16 ? 310 ASP B C 1 ATOM 6708 O O . ASP B 1 310 ? -11.265 18.253 20.134 1.00 53.77 ? 310 ASP B O 1 ATOM 6709 C CB . ASP B 1 310 ? -13.945 18.888 20.476 1.00 52.47 ? 310 ASP B CB 1 ATOM 6710 C CG . ASP B 1 310 ? -15.146 17.967 20.394 1.00 65.74 ? 310 ASP B CG 1 ATOM 6711 O OD1 . ASP B 1 310 ? -14.950 16.755 20.129 1.00 65.92 ? 310 ASP B OD1 1 ATOM 6712 O OD2 . ASP B 1 310 ? -16.287 18.461 20.574 1.00 71.99 ? 310 ASP B OD2 1 ATOM 6713 N N . CYS B 1 311 ? -10.731 18.145 22.360 1.00 50.34 ? 311 CYS B N 1 ATOM 6714 C CA . CYS B 1 311 ? -9.321 17.780 22.232 1.00 49.10 ? 311 CYS B CA 1 ATOM 6715 C C . CYS B 1 311 ? -9.208 16.429 21.520 1.00 48.20 ? 311 CYS B C 1 ATOM 6716 O O . CYS B 1 311 ? -9.697 15.415 22.026 1.00 46.03 ? 311 CYS B O 1 ATOM 6717 C CB . CYS B 1 311 ? -8.639 17.735 23.601 1.00 50.47 ? 311 CYS B CB 1 ATOM 6718 S SG . CYS B 1 311 ? -7.811 19.277 24.098 1.00 55.45 ? 311 CYS B SG 1 ATOM 6719 N N . THR B 1 312 ? -8.592 16.425 20.333 1.00 44.10 ? 312 THR B N 1 ATOM 6720 C CA . THR B 1 312 ? -8.260 15.202 19.607 1.00 43.93 ? 312 THR B CA 1 ATOM 6721 C C . THR B 1 312 ? -6.753 15.129 19.582 1.00 47.46 ? 312 THR B C 1 ATOM 6722 O O . THR B 1 312 ? -6.109 15.983 18.970 1.00 47.23 ? 312 THR B O 1 ATOM 6723 C CB . THR B 1 312 ? -8.862 15.099 18.206 1.00 48.20 ? 312 THR B CB 1 ATOM 6724 O OG1 . THR B 1 312 ? -10.267 15.346 18.266 1.00 49.69 ? 312 THR B OG1 1 ATOM 6725 C CG2 . THR B 1 312 ? -8.615 13.723 17.592 1.00 42.31 ? 312 THR B CG2 1 ATOM 6726 N N . MET B 1 313 ? -6.193 14.140 20.279 1.00 43.18 ? 313 MET B N 1 ATOM 6727 C CA . MET B 1 313 ? -4.741 13.968 20.386 1.00 42.69 ? 313 MET B CA 1 ATOM 6728 C C . MET B 1 313 ? -4.179 12.996 19.359 1.00 40.73 ? 313 MET B C 1 ATOM 6729 O O . MET B 1 313 ? -4.916 12.187 18.812 1.00 39.41 ? 313 MET B O 1 ATOM 6730 C CB . MET B 1 313 ? -4.335 13.498 21.803 1.00 45.85 ? 313 MET B CB 1 ATOM 6731 C CG . MET B 1 313 ? -5.200 14.053 22.925 1.00 50.52 ? 313 MET B CG 1 ATOM 6732 S SD . MET B 1 313 ? -4.247 14.963 24.151 1.00 55.74 ? 313 MET B SD 1 ATOM 6733 C CE . MET B 1 313 ? -3.175 13.673 24.737 1.00 53.10 ? 313 MET B CE 1 ATOM 6734 N N . LEU B 1 314 ? -2.856 13.073 19.134 1.00 35.08 ? 314 LEU B N 1 ATOM 6735 C CA . LEU B 1 314 ? -2.065 12.194 18.274 1.00 34.07 ? 314 LEU B CA 1 ATOM 6736 C C . LEU B 1 314 ? -0.648 12.090 18.859 1.00 37.36 ? 314 LEU B C 1 ATOM 6737 O O . LEU B 1 314 ? 0.233 12.873 18.500 1.00 36.85 ? 314 LEU B O 1 ATOM 6738 C CB . LEU B 1 314 ? -2.059 12.686 16.826 1.00 33.80 ? 314 LEU B CB 1 ATOM 6739 C CG . LEU B 1 314 ? -1.504 11.729 15.777 1.00 37.71 ? 314 LEU B CG 1 ATOM 6740 C CD1 . LEU B 1 314 ? -2.122 10.333 15.908 1.00 37.77 ? 314 LEU B CD1 1 ATOM 6741 C CD2 . LEU B 1 314 ? -1.745 12.282 14.389 1.00 38.58 ? 314 LEU B CD2 1 ATOM 6742 N N . VAL B 1 315 ? -0.453 11.135 19.791 1.00 33.63 ? 315 VAL B N 1 ATOM 6743 C CA . VAL B 1 315 ? 0.788 10.957 20.549 1.00 33.92 ? 315 VAL B CA 1 ATOM 6744 C C . VAL B 1 315 ? 1.679 9.841 19.991 1.00 38.73 ? 315 VAL B C 1 ATOM 6745 O O . VAL B 1 315 ? 1.227 8.724 19.764 1.00 39.04 ? 315 VAL B O 1 ATOM 6746 C CB . VAL B 1 315 ? 0.524 10.771 22.076 1.00 38.12 ? 315 VAL B CB 1 ATOM 6747 C CG1 . VAL B 1 315 ? 1.811 10.902 22.879 1.00 38.37 ? 315 VAL B CG1 1 ATOM 6748 C CG2 . VAL B 1 315 ? -0.513 11.755 22.602 1.00 37.96 ? 315 VAL B CG2 1 ATOM 6749 N N . ASN B 1 316 ? 2.951 10.152 19.795 1.00 35.68 ? 316 ASN B N 1 ATOM 6750 C CA . ASN B 1 316 ? 3.956 9.214 19.314 1.00 36.22 ? 316 ASN B CA 1 ATOM 6751 C C . ASN B 1 316 ? 5.133 9.452 20.217 1.00 41.29 ? 316 ASN B C 1 ATOM 6752 O O . ASN B 1 316 ? 5.850 10.432 20.035 1.00 41.46 ? 316 ASN B O 1 ATOM 6753 C CB . ASN B 1 316 ? 4.354 9.531 17.876 1.00 37.85 ? 316 ASN B CB 1 ATOM 6754 C CG . ASN B 1 316 ? 3.207 9.604 16.926 1.00 62.64 ? 316 ASN B CG 1 ATOM 6755 O OD1 . ASN B 1 316 ? 2.498 10.608 16.839 1.00 55.20 ? 316 ASN B OD1 1 ATOM 6756 N ND2 . ASN B 1 316 ? 3.031 8.555 16.167 1.00 59.76 ? 316 ASN B ND2 1 ATOM 6757 N N . GLY B 1 317 ? 5.261 8.618 21.241 1.00 37.37 ? 317 GLY B N 1 ATOM 6758 C CA . GLY B 1 317 ? 6.298 8.782 22.241 1.00 36.31 ? 317 GLY B CA 1 ATOM 6759 C C . GLY B 1 317 ? 6.193 10.141 22.891 1.00 38.37 ? 317 GLY B C 1 ATOM 6760 O O . GLY B 1 317 ? 5.152 10.486 23.456 1.00 38.48 ? 317 GLY B O 1 ATOM 6761 N N . ASP B 1 318 ? 7.240 10.944 22.736 1.00 34.09 ? 318 ASP B N 1 ATOM 6762 C CA . ASP B 1 318 ? 7.335 12.284 23.300 1.00 34.14 ? 318 ASP B CA 1 ATOM 6763 C C . ASP B 1 318 ? 6.690 13.354 22.415 1.00 40.18 ? 318 ASP B C 1 ATOM 6764 O O . ASP B 1 318 ? 6.521 14.493 22.851 1.00 40.11 ? 318 ASP B O 1 ATOM 6765 C CB . ASP B 1 318 ? 8.806 12.612 23.598 1.00 35.63 ? 318 ASP B CB 1 ATOM 6766 C CG . ASP B 1 318 ? 9.722 12.760 22.395 1.00 44.49 ? 318 ASP B CG 1 ATOM 6767 O OD1 . ASP B 1 318 ? 9.431 12.142 21.344 1.00 45.08 ? 318 ASP B OD1 1 ATOM 6768 O OD2 . ASP B 1 318 ? 10.758 13.461 22.520 1.00 48.40 ? 318 ASP B OD2 1 ATOM 6769 N N . ASP B 1 319 ? 6.333 12.982 21.177 1.00 38.26 ? 319 ASP B N 1 ATOM 6770 C CA . ASP B 1 319 ? 5.735 13.861 20.179 1.00 38.42 ? 319 ASP B CA 1 ATOM 6771 C C . ASP B 1 319 ? 4.219 13.882 20.274 1.00 42.88 ? 319 ASP B C 1 ATOM 6772 O O . ASP B 1 319 ? 3.592 12.825 20.186 1.00 42.71 ? 319 ASP B O 1 ATOM 6773 C CB . ASP B 1 319 ? 6.185 13.430 18.783 1.00 40.63 ? 319 ASP B CB 1 ATOM 6774 C CG . ASP B 1 319 ? 6.859 14.526 18.005 1.00 55.31 ? 319 ASP B CG 1 ATOM 6775 O OD1 . ASP B 1 319 ? 6.140 15.343 17.400 1.00 57.18 ? 319 ASP B OD1 1 ATOM 6776 O OD2 . ASP B 1 319 ? 8.115 14.565 17.995 1.00 60.58 ? 319 ASP B OD2 1 ATOM 6777 N N . LEU B 1 320 ? 3.635 15.097 20.440 1.00 39.38 ? 320 LEU B N 1 ATOM 6778 C CA . LEU B 1 320 ? 2.194 15.345 20.556 1.00 38.53 ? 320 LEU B CA 1 ATOM 6779 C C . LEU B 1 320 ? 1.655 16.364 19.556 1.00 42.13 ? 320 LEU B C 1 ATOM 6780 O O . LEU B 1 320 ? 2.292 17.383 19.308 1.00 40.59 ? 320 LEU B O 1 ATOM 6781 C CB . LEU B 1 320 ? 1.854 15.822 21.984 1.00 38.52 ? 320 LEU B CB 1 ATOM 6782 C CG . LEU B 1 320 ? 0.433 16.383 22.207 1.00 42.88 ? 320 LEU B CG 1 ATOM 6783 C CD1 . LEU B 1 320 ? -0.512 15.311 22.649 1.00 42.98 ? 320 LEU B CD1 1 ATOM 6784 C CD2 . LEU B 1 320 ? 0.430 17.521 23.183 1.00 45.32 ? 320 LEU B CD2 1 ATOM 6785 N N . VAL B 1 321 ? 0.425 16.113 19.060 1.00 40.02 ? 321 VAL B N 1 ATOM 6786 C CA . VAL B 1 321 ? -0.365 16.997 18.209 1.00 39.90 ? 321 VAL B CA 1 ATOM 6787 C C . VAL B 1 321 ? -1.795 16.925 18.716 1.00 43.40 ? 321 VAL B C 1 ATOM 6788 O O . VAL B 1 321 ? -2.342 15.823 18.832 1.00 43.23 ? 321 VAL B O 1 ATOM 6789 C CB . VAL B 1 321 ? -0.248 16.675 16.698 1.00 43.95 ? 321 VAL B CB 1 ATOM 6790 C CG1 . VAL B 1 321 ? -1.466 17.159 15.912 1.00 43.55 ? 321 VAL B CG1 1 ATOM 6791 C CG2 . VAL B 1 321 ? 0.994 17.307 16.128 1.00 44.05 ? 321 VAL B CG2 1 ATOM 6792 N N . VAL B 1 322 ? -2.381 18.094 19.046 1.00 38.31 ? 322 VAL B N 1 ATOM 6793 C CA . VAL B 1 322 ? -3.769 18.235 19.488 1.00 37.17 ? 322 VAL B CA 1 ATOM 6794 C C . VAL B 1 322 ? -4.534 19.071 18.454 1.00 40.49 ? 322 VAL B C 1 ATOM 6795 O O . VAL B 1 322 ? -4.019 20.079 17.963 1.00 40.64 ? 322 VAL B O 1 ATOM 6796 C CB . VAL B 1 322 ? -3.895 18.853 20.904 1.00 40.86 ? 322 VAL B CB 1 ATOM 6797 C CG1 . VAL B 1 322 ? -5.352 18.935 21.361 1.00 40.65 ? 322 VAL B CG1 1 ATOM 6798 C CG2 . VAL B 1 322 ? -3.060 18.100 21.926 1.00 40.65 ? 322 VAL B CG2 1 ATOM 6799 N N . ILE B 1 323 ? -5.738 18.626 18.102 1.00 36.17 ? 323 ILE B N 1 ATOM 6800 C CA . ILE B 1 323 ? -6.647 19.346 17.214 1.00 36.20 ? 323 ILE B CA 1 ATOM 6801 C C . ILE B 1 323 ? -7.944 19.496 18.011 1.00 40.87 ? 323 ILE B C 1 ATOM 6802 O O . ILE B 1 323 ? -8.521 18.511 18.464 1.00 40.92 ? 323 ILE B O 1 ATOM 6803 C CB . ILE B 1 323 ? -6.840 18.714 15.804 1.00 39.38 ? 323 ILE B CB 1 ATOM 6804 C CG1 . ILE B 1 323 ? -5.506 18.660 15.001 1.00 39.05 ? 323 ILE B CG1 1 ATOM 6805 C CG2 . ILE B 1 323 ? -7.937 19.466 15.014 1.00 40.23 ? 323 ILE B CG2 1 ATOM 6806 C CD1 . ILE B 1 323 ? -5.487 17.680 13.787 1.00 34.00 ? 323 ILE B CD1 1 ATOM 6807 N N . CYS B 1 324 ? -8.334 20.733 18.260 1.00 38.23 ? 324 CYS B N 1 ATOM 6808 C CA . CYS B 1 324 ? -9.491 21.088 19.072 1.00 38.30 ? 324 CYS B CA 1 ATOM 6809 C C . CYS B 1 324 ? -10.294 22.233 18.410 1.00 45.70 ? 324 CYS B C 1 ATOM 6810 O O . CYS B 1 324 ? -9.842 22.829 17.426 1.00 45.30 ? 324 CYS B O 1 ATOM 6811 C CB . CYS B 1 324 ? -9.010 21.490 20.461 1.00 37.38 ? 324 CYS B CB 1 ATOM 6812 S SG . CYS B 1 324 ? -7.782 22.818 20.440 1.00 40.65 ? 324 CYS B SG 1 ATOM 6813 N N . GLU B 1 325 ? -11.472 22.547 18.980 1.00 43.75 ? 325 GLU B N 1 ATOM 6814 C CA . GLU B 1 325 ? -12.314 23.644 18.533 1.00 44.18 ? 325 GLU B CA 1 ATOM 6815 C C . GLU B 1 325 ? -11.686 24.980 18.951 1.00 51.98 ? 325 GLU B C 1 ATOM 6816 O O . GLU B 1 325 ? -11.266 25.141 20.105 1.00 52.46 ? 325 GLU B O 1 ATOM 6817 C CB . GLU B 1 325 ? -13.723 23.509 19.119 1.00 45.31 ? 325 GLU B CB 1 ATOM 6818 C CG . GLU B 1 325 ? -14.598 22.490 18.412 1.00 54.16 ? 325 GLU B CG 1 ATOM 6819 C CD . GLU B 1 325 ? -15.169 22.860 17.054 1.00 70.61 ? 325 GLU B CD 1 ATOM 6820 O OE1 . GLU B 1 325 ? -15.914 22.019 16.500 1.00 70.81 ? 325 GLU B OE1 1 ATOM 6821 O OE2 . GLU B 1 325 ? -14.874 23.964 16.536 1.00 54.84 ? 325 GLU B OE2 1 ATOM 6822 N N . SER B 1 326 ? -11.603 25.921 17.996 1.00 50.48 ? 326 SER B N 1 ATOM 6823 C CA . SER B 1 326 ? -11.056 27.270 18.165 1.00 51.06 ? 326 SER B CA 1 ATOM 6824 C C . SER B 1 326 ? -12.070 28.150 18.885 1.00 57.09 ? 326 SER B C 1 ATOM 6825 O O . SER B 1 326 ? -13.273 27.929 18.753 1.00 56.30 ? 326 SER B O 1 ATOM 6826 C CB . SER B 1 326 ? -10.721 27.871 16.800 1.00 54.54 ? 326 SER B CB 1 ATOM 6827 O OG . SER B 1 326 ? -10.152 29.165 16.876 1.00 63.60 ? 326 SER B OG 1 ATOM 6828 N N . ALA B 1 327 ? -11.578 29.142 19.649 1.00 56.53 ? 327 ALA B N 1 ATOM 6829 C CA . ALA B 1 327 ? -12.390 30.118 20.393 1.00 57.41 ? 327 ALA B CA 1 ATOM 6830 C C . ALA B 1 327 ? -11.824 31.529 20.151 1.00 64.56 ? 327 ALA B C 1 ATOM 6831 O O . ALA B 1 327 ? -11.910 32.415 21.015 1.00 65.15 ? 327 ALA B O 1 ATOM 6832 C CB . ALA B 1 327 ? -12.378 29.779 21.882 1.00 58.03 ? 327 ALA B CB 1 ATOM 6833 N N . GLY B 1 328 ? -11.258 31.717 18.959 1.00 62.60 ? 328 GLY B N 1 ATOM 6834 C CA . GLY B 1 328 ? -10.609 32.956 18.548 1.00 63.03 ? 328 GLY B CA 1 ATOM 6835 C C . GLY B 1 328 ? -9.152 32.927 18.959 1.00 68.02 ? 328 GLY B C 1 ATOM 6836 O O . GLY B 1 328 ? -8.813 32.335 19.991 1.00 67.93 ? 328 GLY B O 1 ATOM 6837 N N . THR B 1 329 ? -8.281 33.574 18.164 1.00 64.29 ? 329 THR B N 1 ATOM 6838 C CA . THR B 1 329 ? -6.828 33.606 18.389 1.00 63.64 ? 329 THR B CA 1 ATOM 6839 C C . THR B 1 329 ? -6.376 33.970 19.818 1.00 64.45 ? 329 THR B C 1 ATOM 6840 O O . THR B 1 329 ? -5.344 33.444 20.237 1.00 63.86 ? 329 THR B O 1 ATOM 6841 C CB . THR B 1 329 ? -6.132 34.514 17.378 1.00 73.77 ? 329 THR B CB 1 ATOM 6842 O OG1 . THR B 1 329 ? -6.653 35.838 17.506 1.00 73.35 ? 329 THR B OG1 1 ATOM 6843 C CG2 . THR B 1 329 ? -6.262 34.006 15.942 1.00 74.32 ? 329 THR B CG2 1 ATOM 6844 N N . GLN B 1 330 ? -7.124 34.845 20.555 1.00 58.45 ? 330 GLN B N 1 ATOM 6845 C CA . GLN B 1 330 ? -6.736 35.296 21.909 1.00 56.75 ? 330 GLN B CA 1 ATOM 6846 C C . GLN B 1 330 ? -7.092 34.293 23.011 1.00 57.48 ? 330 GLN B C 1 ATOM 6847 O O . GLN B 1 330 ? -6.262 34.053 23.893 1.00 55.66 ? 330 GLN B O 1 ATOM 6848 C CB . GLN B 1 330 ? -7.263 36.701 22.229 1.00 57.58 ? 330 GLN B CB 1 ATOM 6849 C CG . GLN B 1 330 ? -6.771 37.803 21.270 1.00 70.60 ? 330 GLN B CG 1 ATOM 6850 C CD . GLN B 1 330 ? -5.273 37.843 21.016 1.00 88.07 ? 330 GLN B CD 1 ATOM 6851 O OE1 . GLN B 1 330 ? -4.468 38.168 21.894 1.00 83.99 ? 330 GLN B OE1 1 ATOM 6852 N NE2 . GLN B 1 330 ? -4.873 37.547 19.791 1.00 77.88 ? 330 GLN B NE2 1 ATOM 6853 N N . GLU B 1 331 ? -8.289 33.685 22.944 1.00 53.08 ? 331 GLU B N 1 ATOM 6854 C CA . GLU B 1 331 ? -8.697 32.649 23.899 1.00 52.25 ? 331 GLU B CA 1 ATOM 6855 C C . GLU B 1 331 ? -7.871 31.372 23.654 1.00 53.48 ? 331 GLU B C 1 ATOM 6856 O O . GLU B 1 331 ? -7.493 30.689 24.609 1.00 53.56 ? 331 GLU B O 1 ATOM 6857 C CB . GLU B 1 331 ? -10.208 32.375 23.814 1.00 54.07 ? 331 GLU B CB 1 ATOM 6858 C CG . GLU B 1 331 ? -10.773 31.513 24.940 1.00 70.76 ? 331 GLU B CG 1 ATOM 6859 C CD . GLU B 1 331 ? -10.496 31.961 26.364 1.00 108.32 ? 331 GLU B CD 1 ATOM 6860 O OE1 . GLU B 1 331 ? -10.546 33.183 26.633 1.00 113.37 ? 331 GLU B OE1 1 ATOM 6861 O OE2 . GLU B 1 331 ? -10.234 31.081 27.215 1.00 111.58 ? 331 GLU B OE2 1 ATOM 6862 N N . ASP B 1 332 ? -7.555 31.084 22.376 1.00 47.19 ? 332 ASP B N 1 ATOM 6863 C CA . ASP B 1 332 ? -6.716 29.956 22.006 1.00 45.73 ? 332 ASP B CA 1 ATOM 6864 C C . ASP B 1 332 ? -5.301 30.149 22.535 1.00 46.95 ? 332 ASP B C 1 ATOM 6865 O O . ASP B 1 332 ? -4.723 29.198 23.070 1.00 47.52 ? 332 ASP B O 1 ATOM 6866 C CB . ASP B 1 332 ? -6.713 29.759 20.489 1.00 47.81 ? 332 ASP B CB 1 ATOM 6867 C CG . ASP B 1 332 ? -8.024 29.241 19.912 1.00 58.87 ? 332 ASP B CG 1 ATOM 6868 O OD1 . ASP B 1 332 ? -8.933 28.885 20.707 1.00 56.23 ? 332 ASP B OD1 1 ATOM 6869 O OD2 . ASP B 1 332 ? -8.141 29.187 18.670 1.00 67.62 ? 332 ASP B OD2 1 ATOM 6870 N N . ALA B 1 333 ? -4.761 31.380 22.436 1.00 40.62 ? 333 ALA B N 1 ATOM 6871 C CA . ALA B 1 333 ? -3.426 31.705 22.934 1.00 39.59 ? 333 ALA B CA 1 ATOM 6872 C C . ALA B 1 333 ? -3.408 31.613 24.452 1.00 43.06 ? 333 ALA B C 1 ATOM 6873 O O . ALA B 1 333 ? -2.406 31.196 25.025 1.00 42.97 ? 333 ALA B O 1 ATOM 6874 C CB . ALA B 1 333 ? -3.018 33.092 22.494 1.00 40.12 ? 333 ALA B CB 1 ATOM 6875 N N . ALA B 1 334 ? -4.543 31.955 25.091 1.00 38.86 ? 334 ALA B N 1 ATOM 6876 C CA . ALA B 1 334 ? -4.738 31.895 26.536 1.00 38.03 ? 334 ALA B CA 1 ATOM 6877 C C . ALA B 1 334 ? -4.686 30.436 27.007 1.00 40.53 ? 334 ALA B C 1 ATOM 6878 O O . ALA B 1 334 ? -3.866 30.093 27.867 1.00 38.18 ? 334 ALA B O 1 ATOM 6879 C CB . ALA B 1 334 ? -6.078 32.526 26.902 1.00 38.53 ? 334 ALA B CB 1 ATOM 6880 N N . SER B 1 335 ? -5.536 29.580 26.392 1.00 36.75 ? 335 SER B N 1 ATOM 6881 C CA . SER B 1 335 ? -5.639 28.151 26.625 1.00 35.81 ? 335 SER B CA 1 ATOM 6882 C C . SER B 1 335 ? -4.294 27.446 26.563 1.00 41.97 ? 335 SER B C 1 ATOM 6883 O O . SER B 1 335 ? -3.980 26.667 27.468 1.00 41.33 ? 335 SER B O 1 ATOM 6884 C CB . SER B 1 335 ? -6.586 27.548 25.611 1.00 36.57 ? 335 SER B CB 1 ATOM 6885 O OG . SER B 1 335 ? -7.909 27.819 26.032 1.00 44.76 ? 335 SER B OG 1 ATOM 6886 N N . LEU B 1 336 ? -3.470 27.773 25.531 1.00 39.76 ? 336 LEU B N 1 ATOM 6887 C CA . LEU B 1 336 ? -2.136 27.192 25.340 1.00 38.83 ? 336 LEU B CA 1 ATOM 6888 C C . LEU B 1 336 ? -1.177 27.591 26.440 1.00 43.40 ? 336 LEU B C 1 ATOM 6889 O O . LEU B 1 336 ? -0.336 26.765 26.804 1.00 44.86 ? 336 LEU B O 1 ATOM 6890 C CB . LEU B 1 336 ? -1.532 27.463 23.947 1.00 38.69 ? 336 LEU B CB 1 ATOM 6891 C CG . LEU B 1 336 ? -2.269 26.967 22.693 1.00 42.98 ? 336 LEU B CG 1 ATOM 6892 C CD1 . LEU B 1 336 ? -1.319 26.876 21.526 1.00 42.53 ? 336 LEU B CD1 1 ATOM 6893 C CD2 . LEU B 1 336 ? -2.917 25.614 22.909 1.00 46.90 ? 336 LEU B CD2 1 ATOM 6894 N N . ARG B 1 337 ? -1.308 28.820 27.003 1.00 39.84 ? 337 ARG B N 1 ATOM 6895 C CA . ARG B 1 337 ? -0.448 29.247 28.127 1.00 39.94 ? 337 ARG B CA 1 ATOM 6896 C C . ARG B 1 337 ? -0.781 28.395 29.323 1.00 43.50 ? 337 ARG B C 1 ATOM 6897 O O . ARG B 1 337 ? 0.129 27.887 29.966 1.00 44.13 ? 337 ARG B O 1 ATOM 6898 C CB . ARG B 1 337 ? -0.605 30.735 28.482 1.00 42.02 ? 337 ARG B CB 1 ATOM 6899 C CG . ARG B 1 337 ? -0.091 31.651 27.399 1.00 66.55 ? 337 ARG B CG 1 ATOM 6900 C CD . ARG B 1 337 ? 0.111 33.079 27.830 1.00 85.01 ? 337 ARG B CD 1 ATOM 6901 N NE . ARG B 1 337 ? 0.568 33.820 26.663 1.00 95.77 ? 337 ARG B NE 1 ATOM 6902 C CZ . ARG B 1 337 ? 1.760 34.400 26.573 1.00 108.94 ? 337 ARG B CZ 1 ATOM 6903 N NH1 . ARG B 1 337 ? 2.599 34.372 27.601 1.00 95.18 ? 337 ARG B NH1 1 ATOM 6904 N NH2 . ARG B 1 337 ? 2.108 35.048 25.469 1.00 94.20 ? 337 ARG B NH2 1 ATOM 6905 N N . VAL B 1 338 ? -2.091 28.169 29.562 1.00 39.14 ? 338 VAL B N 1 ATOM 6906 C CA . VAL B 1 338 ? -2.629 27.350 30.649 1.00 38.73 ? 338 VAL B CA 1 ATOM 6907 C C . VAL B 1 338 ? -2.140 25.908 30.460 1.00 44.68 ? 338 VAL B C 1 ATOM 6908 O O . VAL B 1 338 ? -1.703 25.274 31.418 1.00 45.34 ? 338 VAL B O 1 ATOM 6909 C CB . VAL B 1 338 ? -4.185 27.445 30.737 1.00 41.40 ? 338 VAL B CB 1 ATOM 6910 C CG1 . VAL B 1 338 ? -4.726 26.615 31.892 1.00 40.38 ? 338 VAL B CG1 1 ATOM 6911 C CG2 . VAL B 1 338 ? -4.656 28.897 30.870 1.00 41.03 ? 338 VAL B CG2 1 ATOM 6912 N N . PHE B 1 339 ? -2.157 25.425 29.210 1.00 41.05 ? 339 PHE B N 1 ATOM 6913 C CA . PHE B 1 339 ? -1.692 24.090 28.836 1.00 39.89 ? 339 PHE B CA 1 ATOM 6914 C C . PHE B 1 339 ? -0.190 23.920 29.148 1.00 44.28 ? 339 PHE B C 1 ATOM 6915 O O . PHE B 1 339 ? 0.203 22.944 29.799 1.00 44.08 ? 339 PHE B O 1 ATOM 6916 C CB . PHE B 1 339 ? -2.003 23.835 27.361 1.00 40.72 ? 339 PHE B CB 1 ATOM 6917 C CG . PHE B 1 339 ? -1.541 22.511 26.817 1.00 41.72 ? 339 PHE B CG 1 ATOM 6918 C CD1 . PHE B 1 339 ? -0.286 22.379 26.236 1.00 44.21 ? 339 PHE B CD1 1 ATOM 6919 C CD2 . PHE B 1 339 ? -2.376 21.401 26.844 1.00 43.12 ? 339 PHE B CD2 1 ATOM 6920 C CE1 . PHE B 1 339 ? 0.124 21.158 25.702 1.00 44.75 ? 339 PHE B CE1 1 ATOM 6921 C CE2 . PHE B 1 339 ? -1.954 20.178 26.329 1.00 45.59 ? 339 PHE B CE2 1 ATOM 6922 C CZ . PHE B 1 339 ? -0.709 20.066 25.755 1.00 43.48 ? 339 PHE B CZ 1 ATOM 6923 N N . THR B 1 340 ? 0.626 24.901 28.730 1.00 40.11 ? 340 THR B N 1 ATOM 6924 C CA . THR B 1 340 ? 2.076 24.950 28.962 1.00 39.21 ? 340 THR B CA 1 ATOM 6925 C C . THR B 1 340 ? 2.383 25.032 30.475 1.00 42.11 ? 340 THR B C 1 ATOM 6926 O O . THR B 1 340 ? 3.391 24.478 30.919 1.00 40.93 ? 340 THR B O 1 ATOM 6927 C CB . THR B 1 340 ? 2.665 26.124 28.154 1.00 40.04 ? 340 THR B CB 1 ATOM 6928 O OG1 . THR B 1 340 ? 2.280 25.978 26.789 1.00 41.45 ? 340 THR B OG1 1 ATOM 6929 C CG2 . THR B 1 340 ? 4.160 26.225 28.256 1.00 32.27 ? 340 THR B CG2 1 ATOM 6930 N N . GLU B 1 341 ? 1.507 25.725 31.250 1.00 38.20 ? 341 GLU B N 1 ATOM 6931 C CA . GLU B 1 341 ? 1.631 25.870 32.701 1.00 38.18 ? 341 GLU B CA 1 ATOM 6932 C C . GLU B 1 341 ? 1.401 24.498 33.341 1.00 40.03 ? 341 GLU B C 1 ATOM 6933 O O . GLU B 1 341 ? 2.214 24.052 34.156 1.00 38.95 ? 341 GLU B O 1 ATOM 6934 C CB . GLU B 1 341 ? 0.611 26.900 33.248 1.00 40.04 ? 341 GLU B CB 1 ATOM 6935 C CG . GLU B 1 341 ? 1.001 28.358 33.040 1.00 54.71 ? 341 GLU B CG 1 ATOM 6936 C CD . GLU B 1 341 ? -0.021 29.398 33.462 1.00 84.16 ? 341 GLU B CD 1 ATOM 6937 O OE1 . GLU B 1 341 ? -0.459 30.181 32.590 1.00 82.13 ? 341 GLU B OE1 1 ATOM 6938 O OE2 . GLU B 1 341 ? -0.354 29.464 34.667 1.00 89.31 ? 341 GLU B OE2 1 ATOM 6939 N N . ALA B 1 342 ? 0.312 23.816 32.928 1.00 35.11 ? 342 ALA B N 1 ATOM 6940 C CA . ALA B 1 342 ? -0.063 22.490 33.403 1.00 34.13 ? 342 ALA B CA 1 ATOM 6941 C C . ALA B 1 342 ? 1.032 21.468 33.087 1.00 38.79 ? 342 ALA B C 1 ATOM 6942 O O . ALA B 1 342 ? 1.457 20.753 33.995 1.00 38.72 ? 342 ALA B O 1 ATOM 6943 C CB . ALA B 1 342 ? -1.373 22.068 32.773 1.00 34.47 ? 342 ALA B CB 1 ATOM 6944 N N . MET B 1 343 ? 1.529 21.442 31.817 1.00 34.60 ? 343 MET B N 1 ATOM 6945 C CA . MET B 1 343 ? 2.578 20.527 31.359 1.00 33.66 ? 343 MET B CA 1 ATOM 6946 C C . MET B 1 343 ? 3.862 20.653 32.186 1.00 38.16 ? 343 MET B C 1 ATOM 6947 O O . MET B 1 343 ? 4.442 19.633 32.572 1.00 38.63 ? 343 MET B O 1 ATOM 6948 C CB . MET B 1 343 ? 2.858 20.713 29.859 1.00 35.91 ? 343 MET B CB 1 ATOM 6949 C CG . MET B 1 343 ? 1.755 20.192 28.939 1.00 39.33 ? 343 MET B CG 1 ATOM 6950 S SD . MET B 1 343 ? 1.412 18.416 29.079 1.00 43.42 ? 343 MET B SD 1 ATOM 6951 C CE . MET B 1 343 ? 2.624 17.767 28.008 1.00 40.38 ? 343 MET B CE 1 ATOM 6952 N N . THR B 1 344 ? 4.263 21.903 32.500 1.00 34.61 ? 344 THR B N 1 ATOM 6953 C CA . THR B 1 344 ? 5.432 22.259 33.313 1.00 34.40 ? 344 THR B CA 1 ATOM 6954 C C . THR B 1 344 ? 5.241 21.776 34.757 1.00 40.13 ? 344 THR B C 1 ATOM 6955 O O . THR B 1 344 ? 6.212 21.322 35.376 1.00 41.03 ? 344 THR B O 1 ATOM 6956 C CB . THR B 1 344 ? 5.687 23.781 33.215 1.00 36.27 ? 344 THR B CB 1 ATOM 6957 O OG1 . THR B 1 344 ? 5.907 24.128 31.844 1.00 36.07 ? 344 THR B OG1 1 ATOM 6958 C CG2 . THR B 1 344 ? 6.850 24.258 34.077 1.00 29.01 ? 344 THR B CG2 1 ATOM 6959 N N . ARG B 1 345 ? 3.994 21.872 35.290 1.00 36.13 ? 345 ARG B N 1 ATOM 6960 C CA . ARG B 1 345 ? 3.659 21.402 36.646 1.00 35.23 ? 345 ARG B CA 1 ATOM 6961 C C . ARG B 1 345 ? 3.786 19.886 36.729 1.00 37.28 ? 345 ARG B C 1 ATOM 6962 O O . ARG B 1 345 ? 4.233 19.358 37.750 1.00 37.19 ? 345 ARG B O 1 ATOM 6963 C CB . ARG B 1 345 ? 2.246 21.821 37.061 1.00 34.83 ? 345 ARG B CB 1 ATOM 6964 C CG . ARG B 1 345 ? 2.143 23.278 37.474 1.00 44.60 ? 345 ARG B CG 1 ATOM 6965 C CD . ARG B 1 345 ? 0.869 23.547 38.239 1.00 52.30 ? 345 ARG B CD 1 ATOM 6966 N NE . ARG B 1 345 ? -0.318 23.484 37.383 1.00 58.12 ? 345 ARG B NE 1 ATOM 6967 C CZ . ARG B 1 345 ? -0.874 24.538 36.797 1.00 69.20 ? 345 ARG B CZ 1 ATOM 6968 N NH1 . ARG B 1 345 ? -0.347 25.749 36.953 1.00 53.53 ? 345 ARG B NH1 1 ATOM 6969 N NH2 . ARG B 1 345 ? -1.958 24.390 36.046 1.00 53.88 ? 345 ARG B NH2 1 ATOM 6970 N N . TYR B 1 346 ? 3.442 19.204 35.626 1.00 32.49 ? 346 TYR B N 1 ATOM 6971 C CA . TYR B 1 346 ? 3.498 17.764 35.498 1.00 32.31 ? 346 TYR B CA 1 ATOM 6972 C C . TYR B 1 346 ? 4.909 17.274 35.216 1.00 42.84 ? 346 TYR B C 1 ATOM 6973 O O . TYR B 1 346 ? 5.098 16.066 35.096 1.00 44.33 ? 346 TYR B O 1 ATOM 6974 C CB . TYR B 1 346 ? 2.563 17.296 34.377 1.00 32.00 ? 346 TYR B CB 1 ATOM 6975 C CG . TYR B 1 346 ? 1.085 17.567 34.578 1.00 30.96 ? 346 TYR B CG 1 ATOM 6976 C CD1 . TYR B 1 346 ? 0.508 17.505 35.846 1.00 31.67 ? 346 TYR B CD1 1 ATOM 6977 C CD2 . TYR B 1 346 ? 0.242 17.758 33.489 1.00 31.34 ? 346 TYR B CD2 1 ATOM 6978 C CE1 . TYR B 1 346 ? -0.856 17.719 36.031 1.00 30.64 ? 346 TYR B CE1 1 ATOM 6979 C CE2 . TYR B 1 346 ? -1.124 17.959 33.658 1.00 32.22 ? 346 TYR B CE2 1 ATOM 6980 C CZ . TYR B 1 346 ? -1.670 17.945 34.931 1.00 39.69 ? 346 TYR B CZ 1 ATOM 6981 O OH . TYR B 1 346 ? -3.017 18.175 35.087 1.00 41.03 ? 346 TYR B OH 1 ATOM 6982 N N . SER B 1 347 ? 5.903 18.185 35.129 1.00 42.37 ? 347 SER B N 1 ATOM 6983 C CA . SER B 1 347 ? 7.320 17.892 34.838 1.00 43.31 ? 347 SER B CA 1 ATOM 6984 C C . SER B 1 347 ? 7.490 17.448 33.397 1.00 50.82 ? 347 SER B C 1 ATOM 6985 O O . SER B 1 347 ? 7.982 16.344 33.130 1.00 51.75 ? 347 SER B O 1 ATOM 6986 C CB . SER B 1 347 ? 7.925 16.886 35.820 1.00 46.27 ? 347 SER B CB 1 ATOM 6987 O OG . SER B 1 347 ? 9.245 16.518 35.453 1.00 53.74 ? 347 SER B OG 1 ATOM 6988 N N . ALA B 1 348 ? 7.007 18.304 32.470 1.00 47.83 ? 348 ALA B N 1 ATOM 6989 C CA . ALA B 1 348 ? 7.091 18.171 31.019 1.00 47.39 ? 348 ALA B CA 1 ATOM 6990 C C . ALA B 1 348 ? 7.070 19.591 30.413 1.00 54.16 ? 348 ALA B C 1 ATOM 6991 O O . ALA B 1 348 ? 6.149 19.911 29.654 1.00 53.87 ? 348 ALA B O 1 ATOM 6992 C CB . ALA B 1 348 ? 5.932 17.335 30.490 1.00 47.68 ? 348 ALA B CB 1 ATOM 6993 N N . PRO B 1 349 ? 8.051 20.481 30.747 1.00 52.79 ? 349 PRO B N 1 ATOM 6994 C CA . PRO B 1 349 ? 8.026 21.839 30.170 1.00 53.34 ? 349 PRO B CA 1 ATOM 6995 C C . PRO B 1 349 ? 8.429 21.837 28.691 1.00 59.04 ? 349 PRO B C 1 ATOM 6996 O O . PRO B 1 349 ? 9.041 20.865 28.249 1.00 58.02 ? 349 PRO B O 1 ATOM 6997 C CB . PRO B 1 349 ? 8.999 22.616 31.055 1.00 55.02 ? 349 PRO B CB 1 ATOM 6998 C CG . PRO B 1 349 ? 9.971 21.598 31.516 1.00 59.12 ? 349 PRO B CG 1 ATOM 6999 C CD . PRO B 1 349 ? 9.232 20.293 31.619 1.00 54.51 ? 349 PRO B CD 1 ATOM 7000 N N . PRO B 1 350 ? 8.060 22.848 27.877 1.00 57.87 ? 350 PRO B N 1 ATOM 7001 C CA . PRO B 1 350 ? 8.405 22.770 26.454 1.00 58.13 ? 350 PRO B CA 1 ATOM 7002 C C . PRO B 1 350 ? 9.747 23.380 26.087 1.00 62.03 ? 350 PRO B C 1 ATOM 7003 O O . PRO B 1 350 ? 10.302 24.194 26.832 1.00 61.97 ? 350 PRO B O 1 ATOM 7004 C CB . PRO B 1 350 ? 7.252 23.524 25.788 1.00 60.07 ? 350 PRO B CB 1 ATOM 7005 C CG . PRO B 1 350 ? 6.880 24.573 26.794 1.00 64.38 ? 350 PRO B CG 1 ATOM 7006 C CD . PRO B 1 350 ? 7.296 24.083 28.170 1.00 59.74 ? 350 PRO B CD 1 ATOM 7007 N N . GLY B 1 351 ? 10.239 22.997 24.918 1.00 58.77 ? 351 GLY B N 1 ATOM 7008 C CA . GLY B 1 351 ? 11.448 23.584 24.356 1.00 58.92 ? 351 GLY B CA 1 ATOM 7009 C C . GLY B 1 351 ? 11.037 24.951 23.859 1.00 62.28 ? 351 GLY B C 1 ATOM 7010 O O . GLY B 1 351 ? 11.411 25.971 24.442 1.00 61.09 ? 351 GLY B O 1 ATOM 7011 N N . ASP B 1 352 ? 10.151 24.948 22.850 1.00 59.43 ? 352 ASP B N 1 ATOM 7012 C CA . ASP B 1 352 ? 9.533 26.134 22.262 1.00 59.51 ? 352 ASP B CA 1 ATOM 7013 C C . ASP B 1 352 ? 8.032 26.048 22.572 1.00 62.84 ? 352 ASP B C 1 ATOM 7014 O O . ASP B 1 352 ? 7.436 24.994 22.323 1.00 62.54 ? 352 ASP B O 1 ATOM 7015 C CB . ASP B 1 352 ? 9.817 26.236 20.747 1.00 61.60 ? 352 ASP B CB 1 ATOM 7016 C CG . ASP B 1 352 ? 11.120 26.957 20.399 1.00 71.62 ? 352 ASP B CG 1 ATOM 7017 O OD1 . ASP B 1 352 ? 11.352 28.071 20.936 1.00 71.71 ? 352 ASP B OD1 1 ATOM 7018 O OD2 . ASP B 1 352 ? 11.892 26.422 19.570 1.00 76.41 ? 352 ASP B OD2 1 ATOM 7019 N N . PRO B 1 353 ? 7.430 27.073 23.229 1.00 58.43 ? 353 PRO B N 1 ATOM 7020 C CA . PRO B 1 353 ? 6.011 26.956 23.614 1.00 57.83 ? 353 PRO B CA 1 ATOM 7021 C C . PRO B 1 353 ? 5.059 26.872 22.418 1.00 60.52 ? 353 PRO B C 1 ATOM 7022 O O . PRO B 1 353 ? 5.358 27.454 21.373 1.00 60.08 ? 353 PRO B O 1 ATOM 7023 C CB . PRO B 1 353 ? 5.773 28.168 24.519 1.00 59.69 ? 353 PRO B CB 1 ATOM 7024 C CG . PRO B 1 353 ? 6.810 29.150 24.116 1.00 64.04 ? 353 PRO B CG 1 ATOM 7025 C CD . PRO B 1 353 ? 8.003 28.367 23.655 1.00 59.53 ? 353 PRO B CD 1 ATOM 7026 N N . PRO B 1 354 ? 3.953 26.088 22.528 1.00 56.26 ? 354 PRO B N 1 ATOM 7027 C CA . PRO B 1 354 ? 3.050 25.912 21.377 1.00 55.45 ? 354 PRO B CA 1 ATOM 7028 C C . PRO B 1 354 ? 2.322 27.163 20.902 1.00 58.56 ? 354 PRO B C 1 ATOM 7029 O O . PRO B 1 354 ? 1.946 28.026 21.708 1.00 58.61 ? 354 PRO B O 1 ATOM 7030 C CB . PRO B 1 354 ? 2.062 24.847 21.866 1.00 56.94 ? 354 PRO B CB 1 ATOM 7031 C CG . PRO B 1 354 ? 2.066 24.964 23.338 1.00 61.26 ? 354 PRO B CG 1 ATOM 7032 C CD . PRO B 1 354 ? 3.489 25.289 23.683 1.00 57.33 ? 354 PRO B CD 1 ATOM 7033 N N . GLN B 1 355 ? 2.117 27.241 19.579 1.00 53.76 ? 355 GLN B N 1 ATOM 7034 C CA . GLN B 1 355 ? 1.413 28.337 18.919 1.00 53.20 ? 355 GLN B CA 1 ATOM 7035 C C . GLN B 1 355 ? 0.170 27.799 18.203 1.00 54.00 ? 355 GLN B C 1 ATOM 7036 O O . GLN B 1 355 ? 0.264 26.755 17.543 1.00 53.18 ? 355 GLN B O 1 ATOM 7037 C CB . GLN B 1 355 ? 2.327 29.062 17.919 1.00 54.96 ? 355 GLN B CB 1 ATOM 7038 C CG . GLN B 1 355 ? 3.166 30.183 18.534 1.00 76.74 ? 355 GLN B CG 1 ATOM 7039 C CD . GLN B 1 355 ? 4.108 30.800 17.522 1.00 109.89 ? 355 GLN B CD 1 ATOM 7040 O OE1 . GLN B 1 355 ? 3.730 31.135 16.388 1.00 108.90 ? 355 GLN B OE1 1 ATOM 7041 N NE2 . GLN B 1 355 ? 5.364 30.969 17.912 1.00 105.59 ? 355 GLN B NE2 1 ATOM 7042 N N . PRO B 1 356 ? -1.002 28.484 18.318 1.00 47.95 ? 356 PRO B N 1 ATOM 7043 C CA . PRO B 1 356 ? -2.203 28.002 17.615 1.00 46.40 ? 356 PRO B CA 1 ATOM 7044 C C . PRO B 1 356 ? -2.075 28.154 16.104 1.00 45.87 ? 356 PRO B C 1 ATOM 7045 O O . PRO B 1 356 ? -1.642 29.188 15.602 1.00 43.97 ? 356 PRO B O 1 ATOM 7046 C CB . PRO B 1 356 ? -3.345 28.860 18.189 1.00 48.30 ? 356 PRO B CB 1 ATOM 7047 C CG . PRO B 1 356 ? -2.754 29.647 19.314 1.00 52.87 ? 356 PRO B CG 1 ATOM 7048 C CD . PRO B 1 356 ? -1.285 29.736 19.047 1.00 48.96 ? 356 PRO B CD 1 ATOM 7049 N N . GLU B 1 357 ? -2.395 27.074 15.397 1.00 41.72 ? 357 GLU B N 1 ATOM 7050 C CA . GLU B 1 357 ? -2.344 26.986 13.943 1.00 40.78 ? 357 GLU B CA 1 ATOM 7051 C C . GLU B 1 357 ? -3.744 26.763 13.427 1.00 44.64 ? 357 GLU B C 1 ATOM 7052 O O . GLU B 1 357 ? -4.513 25.990 14.011 1.00 43.84 ? 357 GLU B O 1 ATOM 7053 C CB . GLU B 1 357 ? -1.357 25.902 13.463 1.00 41.75 ? 357 GLU B CB 1 ATOM 7054 C CG . GLU B 1 357 ? 0.099 26.175 13.825 1.00 49.99 ? 357 GLU B CG 1 ATOM 7055 C CD . GLU B 1 357 ? 0.755 27.417 13.245 1.00 67.96 ? 357 GLU B CD 1 ATOM 7056 O OE1 . GLU B 1 357 ? 0.304 27.901 12.181 1.00 68.09 ? 357 GLU B OE1 1 ATOM 7057 O OE2 . GLU B 1 357 ? 1.740 27.898 13.849 1.00 53.99 ? 357 GLU B OE2 1 ATOM 7058 N N . TYR B 1 358 ? -4.092 27.502 12.365 1.00 41.61 ? 358 TYR B N 1 ATOM 7059 C CA . TYR B 1 358 ? -5.424 27.502 11.768 1.00 40.97 ? 358 TYR B CA 1 ATOM 7060 C C . TYR B 1 358 ? -5.408 26.886 10.376 1.00 45.50 ? 358 TYR B C 1 ATOM 7061 O O . TYR B 1 358 ? -6.413 26.894 9.665 1.00 45.71 ? 358 TYR B O 1 ATOM 7062 C CB . TYR B 1 358 ? -6.014 28.931 11.827 1.00 41.15 ? 358 TYR B CB 1 ATOM 7063 C CG . TYR B 1 358 ? -6.092 29.438 13.259 1.00 41.54 ? 358 TYR B CG 1 ATOM 7064 C CD1 . TYR B 1 358 ? -7.158 29.087 14.087 1.00 43.30 ? 358 TYR B CD1 1 ATOM 7065 C CD2 . TYR B 1 358 ? -5.046 30.169 13.822 1.00 41.51 ? 358 TYR B CD2 1 ATOM 7066 C CE1 . TYR B 1 358 ? -7.206 29.491 15.421 1.00 42.67 ? 358 TYR B CE1 1 ATOM 7067 C CE2 . TYR B 1 358 ? -5.074 30.559 15.167 1.00 42.02 ? 358 TYR B CE2 1 ATOM 7068 C CZ . TYR B 1 358 ? -6.160 30.219 15.961 1.00 47.76 ? 358 TYR B CZ 1 ATOM 7069 O OH . TYR B 1 358 ? -6.214 30.592 17.286 1.00 49.37 ? 358 TYR B OH 1 ATOM 7070 N N . ASP B 1 359 ? -4.277 26.259 10.041 1.00 42.68 ? 359 ASP B N 1 ATOM 7071 C CA . ASP B 1 359 ? -4.037 25.556 8.787 1.00 43.02 ? 359 ASP B CA 1 ATOM 7072 C C . ASP B 1 359 ? -3.263 24.300 9.128 1.00 45.25 ? 359 ASP B C 1 ATOM 7073 O O . ASP B 1 359 ? -2.190 24.392 9.733 1.00 44.35 ? 359 ASP B O 1 ATOM 7074 C CB . ASP B 1 359 ? -3.246 26.456 7.818 1.00 45.59 ? 359 ASP B CB 1 ATOM 7075 C CG . ASP B 1 359 ? -2.834 25.821 6.503 1.00 61.56 ? 359 ASP B CG 1 ATOM 7076 O OD1 . ASP B 1 359 ? -3.626 25.019 5.951 1.00 63.33 ? 359 ASP B OD1 1 ATOM 7077 O OD2 . ASP B 1 359 ? -1.747 26.168 5.996 1.00 70.69 ? 359 ASP B OD2 1 ATOM 7078 N N . LEU B 1 360 ? -3.835 23.128 8.779 1.00 41.10 ? 360 LEU B N 1 ATOM 7079 C CA . LEU B 1 360 ? -3.265 21.795 9.023 1.00 40.66 ? 360 LEU B CA 1 ATOM 7080 C C . LEU B 1 360 ? -1.824 21.701 8.548 1.00 46.43 ? 360 LEU B C 1 ATOM 7081 O O . LEU B 1 360 ? -0.974 21.243 9.298 1.00 47.11 ? 360 LEU B O 1 ATOM 7082 C CB . LEU B 1 360 ? -4.122 20.711 8.342 1.00 40.18 ? 360 LEU B CB 1 ATOM 7083 C CG . LEU B 1 360 ? -3.773 19.261 8.648 1.00 43.47 ? 360 LEU B CG 1 ATOM 7084 C CD1 . LEU B 1 360 ? -3.926 18.962 10.118 1.00 43.24 ? 360 LEU B CD1 1 ATOM 7085 C CD2 . LEU B 1 360 ? -4.627 18.314 7.830 1.00 44.54 ? 360 LEU B CD2 1 ATOM 7086 N N . GLU B 1 361 ? -1.546 22.204 7.332 1.00 43.75 ? 361 GLU B N 1 ATOM 7087 C CA . GLU B 1 361 ? -0.229 22.232 6.687 1.00 43.32 ? 361 GLU B CA 1 ATOM 7088 C C . GLU B 1 361 ? 0.815 23.032 7.458 1.00 46.40 ? 361 GLU B C 1 ATOM 7089 O O . GLU B 1 361 ? 1.986 22.989 7.087 1.00 46.54 ? 361 GLU B O 1 ATOM 7090 C CB . GLU B 1 361 ? -0.341 22.783 5.257 1.00 44.79 ? 361 GLU B CB 1 ATOM 7091 C CG . GLU B 1 361 ? -1.254 22.008 4.326 1.00 55.08 ? 361 GLU B CG 1 ATOM 7092 C CD . GLU B 1 361 ? -1.104 22.349 2.853 1.00 81.96 ? 361 GLU B CD 1 ATOM 7093 O OE1 . GLU B 1 361 ? 0.044 22.520 2.374 1.00 81.43 ? 361 GLU B OE1 1 ATOM 7094 O OE2 . GLU B 1 361 ? -2.147 22.394 2.164 1.00 76.19 ? 361 GLU B OE2 1 ATOM 7095 N N . LEU B 1 362 ? 0.407 23.760 8.519 1.00 43.25 ? 362 LEU B N 1 ATOM 7096 C CA . LEU B 1 362 ? 1.323 24.581 9.331 1.00 43.15 ? 362 LEU B CA 1 ATOM 7097 C C . LEU B 1 362 ? 1.741 23.929 10.671 1.00 45.97 ? 362 LEU B C 1 ATOM 7098 O O . LEU B 1 362 ? 2.719 24.376 11.271 1.00 44.49 ? 362 LEU B O 1 ATOM 7099 C CB . LEU B 1 362 ? 0.777 26.011 9.553 1.00 43.03 ? 362 LEU B CB 1 ATOM 7100 C CG . LEU B 1 362 ? 0.676 26.920 8.313 1.00 46.65 ? 362 LEU B CG 1 ATOM 7101 C CD1 . LEU B 1 362 ? 0.050 28.246 8.671 1.00 46.34 ? 362 LEU B CD1 1 ATOM 7102 C CD2 . LEU B 1 362 ? 2.035 27.157 7.664 1.00 47.30 ? 362 LEU B CD2 1 ATOM 7103 N N . ILE B 1 363 ? 1.039 22.860 11.108 1.00 43.29 ? 363 ILE B N 1 ATOM 7104 C CA . ILE B 1 363 ? 1.379 22.106 12.320 1.00 43.77 ? 363 ILE B CA 1 ATOM 7105 C C . ILE B 1 363 ? 2.564 21.146 12.017 1.00 51.58 ? 363 ILE B C 1 ATOM 7106 O O . ILE B 1 363 ? 2.491 20.334 11.086 1.00 51.06 ? 363 ILE B O 1 ATOM 7107 C CB . ILE B 1 363 ? 0.150 21.351 12.917 1.00 46.21 ? 363 ILE B CB 1 ATOM 7108 C CG1 . ILE B 1 363 ? -1.040 22.287 13.136 1.00 45.74 ? 363 ILE B CG1 1 ATOM 7109 C CG2 . ILE B 1 363 ? 0.523 20.622 14.226 1.00 46.82 ? 363 ILE B CG2 1 ATOM 7110 C CD1 . ILE B 1 363 ? -2.295 21.624 13.075 1.00 51.67 ? 363 ILE B CD1 1 ATOM 7111 N N . THR B 1 364 ? 3.654 21.251 12.807 1.00 51.36 ? 364 THR B N 1 ATOM 7112 C CA . THR B 1 364 ? 4.846 20.411 12.633 1.00 52.38 ? 364 THR B CA 1 ATOM 7113 C C . THR B 1 364 ? 5.067 19.478 13.822 1.00 57.15 ? 364 THR B C 1 ATOM 7114 O O . THR B 1 364 ? 5.463 19.914 14.901 1.00 57.53 ? 364 THR B O 1 ATOM 7115 C CB . THR B 1 364 ? 6.090 21.265 12.293 1.00 63.82 ? 364 THR B CB 1 ATOM 7116 O OG1 . THR B 1 364 ? 5.839 21.986 11.089 1.00 64.03 ? 364 THR B OG1 1 ATOM 7117 C CG2 . THR B 1 364 ? 7.366 20.427 12.134 1.00 62.07 ? 364 THR B CG2 1 ATOM 7118 N N . SER B 1 365 ? 4.838 18.191 13.595 1.00 54.48 ? 365 SER B N 1 ATOM 7119 C CA . SER B 1 365 ? 5.043 17.113 14.564 1.00 54.78 ? 365 SER B CA 1 ATOM 7120 C C . SER B 1 365 ? 5.832 15.987 13.899 1.00 59.74 ? 365 SER B C 1 ATOM 7121 O O . SER B 1 365 ? 5.677 15.750 12.693 1.00 60.76 ? 365 SER B O 1 ATOM 7122 C CB . SER B 1 365 ? 3.711 16.564 15.040 1.00 57.95 ? 365 SER B CB 1 ATOM 7123 O OG . SER B 1 365 ? 3.882 15.529 15.992 1.00 67.13 ? 365 SER B OG 1 ATOM 7124 N N . CYS B 1 366 ? 6.661 15.280 14.694 1.00 54.51 ? 366 CYS B N 1 ATOM 7125 C CA . CYS B 1 366 ? 7.519 14.184 14.244 1.00 53.33 ? 366 CYS B CA 1 ATOM 7126 C C . CYS B 1 366 ? 8.427 14.691 13.110 1.00 55.41 ? 366 CYS B C 1 ATOM 7127 O O . CYS B 1 366 ? 8.755 13.955 12.173 1.00 55.46 ? 366 CYS B O 1 ATOM 7128 C CB . CYS B 1 366 ? 6.694 12.959 13.839 1.00 53.44 ? 366 CYS B CB 1 ATOM 7129 S SG . CYS B 1 366 ? 5.795 12.176 15.212 1.00 57.19 ? 366 CYS B SG 1 ATOM 7130 N N . SER B 1 367 ? 8.810 15.995 13.213 1.00 49.42 ? 367 SER B N 1 ATOM 7131 C CA . SER B 1 367 ? 9.674 16.748 12.296 1.00 47.72 ? 367 SER B CA 1 ATOM 7132 C C . SER B 1 367 ? 9.072 16.886 10.874 1.00 49.97 ? 367 SER B C 1 ATOM 7133 O O . SER B 1 367 ? 9.698 17.463 9.978 1.00 48.90 ? 367 SER B O 1 ATOM 7134 C CB . SER B 1 367 ? 11.082 16.158 12.278 1.00 49.12 ? 367 SER B CB 1 ATOM 7135 O OG . SER B 1 367 ? 11.606 16.038 13.593 1.00 51.48 ? 367 SER B OG 1 ATOM 7136 N N . SER B 1 368 ? 7.803 16.444 10.724 1.00 45.19 ? 368 SER B N 1 ATOM 7137 C CA . SER B 1 368 ? 7.014 16.440 9.493 1.00 44.25 ? 368 SER B CA 1 ATOM 7138 C C . SER B 1 368 ? 5.793 17.363 9.552 1.00 46.17 ? 368 SER B C 1 ATOM 7139 O O . SER B 1 368 ? 5.482 17.930 10.602 1.00 45.62 ? 368 SER B O 1 ATOM 7140 C CB . SER B 1 368 ? 6.528 15.024 9.198 1.00 47.53 ? 368 SER B CB 1 ATOM 7141 O OG . SER B 1 368 ? 7.621 14.156 8.973 1.00 54.88 ? 368 SER B OG 1 ATOM 7142 N N . ASN B 1 369 ? 5.084 17.470 8.411 1.00 40.70 ? 369 ASN B N 1 ATOM 7143 C CA . ASN B 1 369 ? 3.864 18.262 8.236 1.00 39.22 ? 369 ASN B CA 1 ATOM 7144 C C . ASN B 1 369 ? 3.070 17.766 7.008 1.00 41.77 ? 369 ASN B C 1 ATOM 7145 O O . ASN B 1 369 ? 3.630 17.136 6.102 1.00 39.27 ? 369 ASN B O 1 ATOM 7146 C CB . ASN B 1 369 ? 4.180 19.769 8.111 1.00 36.21 ? 369 ASN B CB 1 ATOM 7147 C CG . ASN B 1 369 ? 5.095 20.057 6.932 1.00 60.61 ? 369 ASN B CG 1 ATOM 7148 O OD1 . ASN B 1 369 ? 6.338 20.004 7.038 1.00 55.36 ? 369 ASN B OD1 1 ATOM 7149 N ND2 . ASN B 1 369 ? 4.497 20.315 5.767 1.00 47.83 ? 369 ASN B ND2 1 ATOM 7150 N N . VAL B 1 370 ? 1.762 18.080 6.988 1.00 40.08 ? 370 VAL B N 1 ATOM 7151 C CA . VAL B 1 370 ? 0.859 17.768 5.879 1.00 40.56 ? 370 VAL B CA 1 ATOM 7152 C C . VAL B 1 370 ? 1.145 18.753 4.733 1.00 48.33 ? 370 VAL B C 1 ATOM 7153 O O . VAL B 1 370 ? 1.522 19.906 4.974 1.00 49.02 ? 370 VAL B O 1 ATOM 7154 C CB . VAL B 1 370 ? -0.644 17.796 6.289 1.00 43.20 ? 370 VAL B CB 1 ATOM 7155 C CG1 . VAL B 1 370 ? -1.540 17.338 5.142 1.00 42.08 ? 370 VAL B CG1 1 ATOM 7156 C CG2 . VAL B 1 370 ? -0.907 16.949 7.529 1.00 43.22 ? 370 VAL B CG2 1 ATOM 7157 N N . SER B 1 371 ? 0.983 18.283 3.493 1.00 46.12 ? 371 SER B N 1 ATOM 7158 C CA . SER B 1 371 ? 1.138 19.090 2.290 1.00 46.61 ? 371 SER B CA 1 ATOM 7159 C C . SER B 1 371 ? 0.228 18.513 1.218 1.00 51.50 ? 371 SER B C 1 ATOM 7160 O O . SER B 1 371 ? -0.285 17.401 1.372 1.00 50.64 ? 371 SER B O 1 ATOM 7161 C CB . SER B 1 371 ? 2.593 19.159 1.833 1.00 50.47 ? 371 SER B CB 1 ATOM 7162 O OG . SER B 1 371 ? 2.927 20.468 1.396 1.00 59.54 ? 371 SER B OG 1 ATOM 7163 N N . VAL B 1 372 ? -0.031 19.295 0.170 1.00 49.37 ? 372 VAL B N 1 ATOM 7164 C CA . VAL B 1 372 ? -0.925 18.874 -0.886 1.00 49.77 ? 372 VAL B CA 1 ATOM 7165 C C . VAL B 1 372 ? -0.200 18.910 -2.254 1.00 54.22 ? 372 VAL B C 1 ATOM 7166 O O . VAL B 1 372 ? 0.734 19.699 -2.476 1.00 53.56 ? 372 VAL B O 1 ATOM 7167 C CB . VAL B 1 372 ? -2.279 19.660 -0.828 1.00 53.89 ? 372 VAL B CB 1 ATOM 7168 C CG1 . VAL B 1 372 ? -2.173 21.047 -1.456 1.00 54.11 ? 372 VAL B CG1 1 ATOM 7169 C CG2 . VAL B 1 372 ? -3.435 18.869 -1.434 1.00 53.57 ? 372 VAL B CG2 1 ATOM 7170 N N . ALA B 1 373 ? -0.595 17.964 -3.112 1.00 50.54 ? 373 ALA B N 1 ATOM 7171 C CA . ALA B 1 373 ? -0.165 17.769 -4.488 1.00 50.51 ? 373 ALA B CA 1 ATOM 7172 C C . ALA B 1 373 ? -1.389 17.189 -5.213 1.00 55.55 ? 373 ALA B C 1 ATOM 7173 O O . ALA B 1 373 ? -2.480 17.202 -4.636 1.00 55.12 ? 373 ALA B O 1 ATOM 7174 C CB . ALA B 1 373 ? 1.012 16.807 -4.536 1.00 51.20 ? 373 ALA B CB 1 ATOM 7175 N N . HIS B 1 374 ? -1.240 16.711 -6.461 1.00 53.12 ? 374 HIS B N 1 ATOM 7176 C CA . HIS B 1 374 ? -2.361 16.148 -7.219 1.00 53.39 ? 374 HIS B CA 1 ATOM 7177 C C . HIS B 1 374 ? -2.039 14.787 -7.814 1.00 58.48 ? 374 HIS B C 1 ATOM 7178 O O . HIS B 1 374 ? -0.899 14.551 -8.203 1.00 59.61 ? 374 HIS B O 1 ATOM 7179 C CB . HIS B 1 374 ? -2.815 17.128 -8.300 1.00 54.40 ? 374 HIS B CB 1 ATOM 7180 C CG . HIS B 1 374 ? -3.136 18.478 -7.749 1.00 57.87 ? 374 HIS B CG 1 ATOM 7181 N ND1 . HIS B 1 374 ? -2.144 19.413 -7.529 1.00 59.68 ? 374 HIS B ND1 1 ATOM 7182 C CD2 . HIS B 1 374 ? -4.313 18.975 -7.305 1.00 59.77 ? 374 HIS B CD2 1 ATOM 7183 C CE1 . HIS B 1 374 ? -2.749 20.463 -6.999 1.00 59.19 ? 374 HIS B CE1 1 ATOM 7184 N NE2 . HIS B 1 374 ? -4.055 20.248 -6.844 1.00 59.56 ? 374 HIS B NE2 1 ATOM 7185 N N . ASP B 1 375 ? -3.036 13.894 -7.892 1.00 54.70 ? 375 ASP B N 1 ATOM 7186 C CA . ASP B 1 375 ? -2.873 12.550 -8.463 1.00 55.01 ? 375 ASP B CA 1 ATOM 7187 C C . ASP B 1 375 ? -2.926 12.590 -10.002 1.00 59.00 ? 375 ASP B C 1 ATOM 7188 O O . ASP B 1 375 ? -2.817 13.668 -10.582 1.00 57.75 ? 375 ASP B O 1 ATOM 7189 C CB . ASP B 1 375 ? -3.928 11.571 -7.884 1.00 57.23 ? 375 ASP B CB 1 ATOM 7190 C CG . ASP B 1 375 ? -5.401 11.863 -8.193 1.00 65.83 ? 375 ASP B CG 1 ATOM 7191 O OD1 . ASP B 1 375 ? -5.675 12.740 -9.041 1.00 65.54 ? 375 ASP B OD1 1 ATOM 7192 O OD2 . ASP B 1 375 ? -6.275 11.204 -7.589 1.00 71.02 ? 375 ASP B OD2 1 ATOM 7193 N N . ALA B 1 376 ? -3.119 11.421 -10.658 1.00 56.75 ? 376 ALA B N 1 ATOM 7194 C CA . ALA B 1 376 ? -3.235 11.324 -12.123 1.00 56.25 ? 376 ALA B CA 1 ATOM 7195 C C . ALA B 1 376 ? -4.507 12.052 -12.603 1.00 60.24 ? 376 ALA B C 1 ATOM 7196 O O . ALA B 1 376 ? -4.441 12.838 -13.550 1.00 60.94 ? 376 ALA B O 1 ATOM 7197 C CB . ALA B 1 376 ? -3.254 9.866 -12.559 1.00 56.60 ? 376 ALA B CB 1 ATOM 7198 N N . SER B 1 377 ? -5.631 11.865 -11.882 1.00 55.26 ? 377 SER B N 1 ATOM 7199 C CA . SER B 1 377 ? -6.920 12.487 -12.181 1.00 54.29 ? 377 SER B CA 1 ATOM 7200 C C . SER B 1 377 ? -6.986 14.004 -11.857 1.00 55.22 ? 377 SER B C 1 ATOM 7201 O O . SER B 1 377 ? -7.953 14.669 -12.233 1.00 54.63 ? 377 SER B O 1 ATOM 7202 C CB . SER B 1 377 ? -8.048 11.722 -11.494 1.00 58.59 ? 377 SER B CB 1 ATOM 7203 O OG . SER B 1 377 ? -8.045 11.918 -10.090 1.00 72.97 ? 377 SER B OG 1 ATOM 7204 N N . GLY B 1 378 ? -5.959 14.529 -11.198 1.00 50.08 ? 378 GLY B N 1 ATOM 7205 C CA . GLY B 1 378 ? -5.882 15.942 -10.834 1.00 49.09 ? 378 GLY B CA 1 ATOM 7206 C C . GLY B 1 378 ? -6.472 16.278 -9.476 1.00 50.15 ? 378 GLY B C 1 ATOM 7207 O O . GLY B 1 378 ? -6.455 17.442 -9.068 1.00 48.10 ? 378 GLY B O 1 ATOM 7208 N N . LYS B 1 379 ? -6.995 15.255 -8.774 1.00 46.69 ? 379 LYS B N 1 ATOM 7209 C CA . LYS B 1 379 ? -7.600 15.318 -7.440 1.00 47.08 ? 379 LYS B CA 1 ATOM 7210 C C . LYS B 1 379 ? -6.576 15.769 -6.378 1.00 52.23 ? 379 LYS B C 1 ATOM 7211 O O . LYS B 1 379 ? -5.485 15.206 -6.308 1.00 52.18 ? 379 LYS B O 1 ATOM 7212 C CB . LYS B 1 379 ? -8.185 13.928 -7.096 1.00 50.01 ? 379 LYS B CB 1 ATOM 7213 C CG . LYS B 1 379 ? -8.749 13.737 -5.682 1.00 59.95 ? 379 LYS B CG 1 ATOM 7214 C CD . LYS B 1 379 ? -9.224 12.293 -5.454 1.00 64.13 ? 379 LYS B CD 1 ATOM 7215 C CE . LYS B 1 379 ? -8.199 11.395 -4.790 1.00 73.16 ? 379 LYS B CE 1 ATOM 7216 N NZ . LYS B 1 379 ? -8.689 10.000 -4.620 1.00 81.94 ? 379 LYS B NZ 1 ATOM 7217 N N . ARG B 1 380 ? -6.929 16.783 -5.561 1.00 49.76 ? 380 ARG B N 1 ATOM 7218 C CA . ARG B 1 380 ? -6.076 17.292 -4.483 1.00 49.86 ? 380 ARG B CA 1 ATOM 7219 C C . ARG B 1 380 ? -5.862 16.173 -3.465 1.00 55.65 ? 380 ARG B C 1 ATOM 7220 O O . ARG B 1 380 ? -6.836 15.630 -2.929 1.00 55.05 ? 380 ARG B O 1 ATOM 7221 C CB . ARG B 1 380 ? -6.715 18.508 -3.809 1.00 49.73 ? 380 ARG B CB 1 ATOM 7222 C CG . ARG B 1 380 ? -6.086 19.831 -4.222 1.00 66.69 ? 380 ARG B CG 1 ATOM 7223 C CD . ARG B 1 380 ? -6.871 21.050 -3.744 1.00 77.18 ? 380 ARG B CD 1 ATOM 7224 N NE . ARG B 1 380 ? -6.899 21.180 -2.280 1.00 81.43 ? 380 ARG B NE 1 ATOM 7225 C CZ . ARG B 1 380 ? -6.083 21.958 -1.571 1.00 85.92 ? 380 ARG B CZ 1 ATOM 7226 N NH1 . ARG B 1 380 ? -5.154 22.688 -2.179 1.00 67.72 ? 380 ARG B NH1 1 ATOM 7227 N NH2 . ARG B 1 380 ? -6.193 22.014 -0.250 1.00 64.22 ? 380 ARG B NH2 1 ATOM 7228 N N . VAL B 1 381 ? -4.586 15.779 -3.265 1.00 53.19 ? 381 VAL B N 1 ATOM 7229 C CA . VAL B 1 381 ? -4.174 14.698 -2.360 1.00 52.92 ? 381 VAL B CA 1 ATOM 7230 C C . VAL B 1 381 ? -3.243 15.209 -1.229 1.00 58.44 ? 381 VAL B C 1 ATOM 7231 O O . VAL B 1 381 ? -2.198 15.816 -1.504 1.00 59.45 ? 381 VAL B O 1 ATOM 7232 C CB . VAL B 1 381 ? -3.563 13.497 -3.155 1.00 55.79 ? 381 VAL B CB 1 ATOM 7233 C CG1 . VAL B 1 381 ? -2.872 12.477 -2.249 1.00 55.69 ? 381 VAL B CG1 1 ATOM 7234 C CG2 . VAL B 1 381 ? -4.599 12.807 -4.035 1.00 55.24 ? 381 VAL B CG2 1 ATOM 7235 N N . TYR B 1 382 ? -3.629 14.933 0.035 1.00 54.24 ? 382 TYR B N 1 ATOM 7236 C CA . TYR B 1 382 ? -2.842 15.259 1.224 1.00 53.82 ? 382 TYR B CA 1 ATOM 7237 C C . TYR B 1 382 ? -1.868 14.115 1.505 1.00 54.90 ? 382 TYR B C 1 ATOM 7238 O O . TYR B 1 382 ? -2.240 12.938 1.426 1.00 54.23 ? 382 TYR B O 1 ATOM 7239 C CB . TYR B 1 382 ? -3.743 15.510 2.451 1.00 55.96 ? 382 TYR B CB 1 ATOM 7240 C CG . TYR B 1 382 ? -4.593 16.750 2.317 1.00 59.46 ? 382 TYR B CG 1 ATOM 7241 C CD1 . TYR B 1 382 ? -4.097 18.001 2.675 1.00 61.84 ? 382 TYR B CD1 1 ATOM 7242 C CD2 . TYR B 1 382 ? -5.868 16.687 1.763 1.00 60.59 ? 382 TYR B CD2 1 ATOM 7243 C CE1 . TYR B 1 382 ? -4.849 19.158 2.485 1.00 63.46 ? 382 TYR B CE1 1 ATOM 7244 C CE2 . TYR B 1 382 ? -6.626 17.837 1.562 1.00 61.74 ? 382 TYR B CE2 1 ATOM 7245 C CZ . TYR B 1 382 ? -6.120 19.069 1.941 1.00 71.29 ? 382 TYR B CZ 1 ATOM 7246 O OH . TYR B 1 382 ? -6.875 20.203 1.767 1.00 74.95 ? 382 TYR B OH 1 ATOM 7247 N N . TYR B 1 383 ? -0.615 14.469 1.806 1.00 48.97 ? 383 TYR B N 1 ATOM 7248 C CA . TYR B 1 383 ? 0.467 13.528 2.107 1.00 47.15 ? 383 TYR B CA 1 ATOM 7249 C C . TYR B 1 383 ? 1.372 14.163 3.162 1.00 48.38 ? 383 TYR B C 1 ATOM 7250 O O . TYR B 1 383 ? 1.291 15.372 3.387 1.00 45.70 ? 383 TYR B O 1 ATOM 7251 C CB . TYR B 1 383 ? 1.266 13.179 0.816 1.00 47.61 ? 383 TYR B CB 1 ATOM 7252 C CG . TYR B 1 383 ? 2.152 14.306 0.327 1.00 48.78 ? 383 TYR B CG 1 ATOM 7253 C CD1 . TYR B 1 383 ? 1.642 15.322 -0.480 1.00 50.47 ? 383 TYR B CD1 1 ATOM 7254 C CD2 . TYR B 1 383 ? 3.491 14.382 0.707 1.00 49.22 ? 383 TYR B CD2 1 ATOM 7255 C CE1 . TYR B 1 383 ? 2.438 16.395 -0.879 1.00 50.45 ? 383 TYR B CE1 1 ATOM 7256 C CE2 . TYR B 1 383 ? 4.295 15.450 0.311 1.00 49.54 ? 383 TYR B CE2 1 ATOM 7257 C CZ . TYR B 1 383 ? 3.764 16.452 -0.482 1.00 54.68 ? 383 TYR B CZ 1 ATOM 7258 O OH . TYR B 1 383 ? 4.560 17.495 -0.878 1.00 55.60 ? 383 TYR B OH 1 ATOM 7259 N N . LEU B 1 384 ? 2.262 13.359 3.769 1.00 46.41 ? 384 LEU B N 1 ATOM 7260 C CA . LEU B 1 384 ? 3.236 13.829 4.764 1.00 46.24 ? 384 LEU B CA 1 ATOM 7261 C C . LEU B 1 384 ? 4.626 14.030 4.170 1.00 49.84 ? 384 LEU B C 1 ATOM 7262 O O . LEU B 1 384 ? 5.165 13.151 3.473 1.00 49.98 ? 384 LEU B O 1 ATOM 7263 C CB . LEU B 1 384 ? 3.303 12.904 5.990 1.00 46.04 ? 384 LEU B CB 1 ATOM 7264 C CG . LEU B 1 384 ? 2.307 13.221 7.080 1.00 50.37 ? 384 LEU B CG 1 ATOM 7265 C CD1 . LEU B 1 384 ? 1.789 11.971 7.708 1.00 50.51 ? 384 LEU B CD1 1 ATOM 7266 C CD2 . LEU B 1 384 ? 2.902 14.175 8.113 1.00 53.29 ? 384 LEU B CD2 1 ATOM 7267 N N . THR B 1 385 ? 5.190 15.200 4.455 1.00 45.24 ? 385 THR B N 1 ATOM 7268 C CA . THR B 1 385 ? 6.520 15.612 4.017 1.00 45.08 ? 385 THR B CA 1 ATOM 7269 C C . THR B 1 385 ? 7.290 16.152 5.207 1.00 49.10 ? 385 THR B C 1 ATOM 7270 O O . THR B 1 385 ? 6.754 16.186 6.308 1.00 50.54 ? 385 THR B O 1 ATOM 7271 C CB . THR B 1 385 ? 6.412 16.626 2.856 1.00 53.76 ? 385 THR B CB 1 ATOM 7272 O OG1 . THR B 1 385 ? 7.720 16.917 2.361 1.00 57.79 ? 385 THR B OG1 1 ATOM 7273 C CG2 . THR B 1 385 ? 5.684 17.912 3.243 1.00 51.37 ? 385 THR B CG2 1 ATOM 7274 N N . ARG B 1 386 ? 8.521 16.606 4.990 1.00 44.14 ? 386 ARG B N 1 ATOM 7275 C CA . ARG B 1 386 ? 9.353 17.207 6.034 1.00 43.47 ? 386 ARG B CA 1 ATOM 7276 C C . ARG B 1 386 ? 10.456 18.021 5.381 1.00 46.63 ? 386 ARG B C 1 ATOM 7277 O O . ARG B 1 386 ? 10.602 17.974 4.156 1.00 45.78 ? 386 ARG B O 1 ATOM 7278 C CB . ARG B 1 386 ? 9.967 16.124 6.926 1.00 41.53 ? 386 ARG B CB 1 ATOM 7279 C CG . ARG B 1 386 ? 10.990 15.242 6.215 1.00 42.42 ? 386 ARG B CG 1 ATOM 7280 C CD . ARG B 1 386 ? 11.867 14.561 7.208 1.00 42.57 ? 386 ARG B CD 1 ATOM 7281 N NE . ARG B 1 386 ? 12.724 15.520 7.900 1.00 41.75 ? 386 ARG B NE 1 ATOM 7282 C CZ . ARG B 1 386 ? 13.287 15.283 9.072 1.00 52.26 ? 386 ARG B CZ 1 ATOM 7283 N NH1 . ARG B 1 386 ? 13.079 14.131 9.695 1.00 42.32 ? 386 ARG B NH1 1 ATOM 7284 N NH2 . ARG B 1 386 ? 14.064 16.196 9.636 1.00 37.54 ? 386 ARG B NH2 1 ATOM 7285 N N . ASP B 1 387 ? 11.256 18.731 6.193 1.00 43.07 ? 387 ASP B N 1 ATOM 7286 C CA . ASP B 1 387 ? 12.398 19.474 5.668 1.00 42.75 ? 387 ASP B CA 1 ATOM 7287 C C . ASP B 1 387 ? 13.433 18.444 5.198 1.00 45.23 ? 387 ASP B C 1 ATOM 7288 O O . ASP B 1 387 ? 13.758 17.524 5.955 1.00 45.40 ? 387 ASP B O 1 ATOM 7289 C CB . ASP B 1 387 ? 12.998 20.425 6.713 1.00 44.67 ? 387 ASP B CB 1 ATOM 7290 C CG . ASP B 1 387 ? 13.773 21.548 6.068 1.00 58.43 ? 387 ASP B CG 1 ATOM 7291 O OD1 . ASP B 1 387 ? 14.846 21.273 5.496 1.00 58.98 ? 387 ASP B OD1 1 ATOM 7292 O OD2 . ASP B 1 387 ? 13.273 22.692 6.074 1.00 67.81 ? 387 ASP B OD2 1 ATOM 7293 N N . PRO B 1 388 ? 13.892 18.502 3.934 1.00 40.38 ? 388 PRO B N 1 ATOM 7294 C CA . PRO B 1 388 ? 14.828 17.469 3.466 1.00 39.44 ? 388 PRO B CA 1 ATOM 7295 C C . PRO B 1 388 ? 16.268 17.620 3.966 1.00 41.69 ? 388 PRO B C 1 ATOM 7296 O O . PRO B 1 388 ? 17.076 16.732 3.698 1.00 41.83 ? 388 PRO B O 1 ATOM 7297 C CB . PRO B 1 388 ? 14.714 17.551 1.939 1.00 41.08 ? 388 PRO B CB 1 ATOM 7298 C CG . PRO B 1 388 ? 14.302 18.948 1.655 1.00 45.64 ? 388 PRO B CG 1 ATOM 7299 C CD . PRO B 1 388 ? 13.601 19.492 2.873 1.00 41.67 ? 388 PRO B CD 1 ATOM 7300 N N . THR B 1 389 ? 16.586 18.698 4.718 1.00 36.94 ? 389 THR B N 1 ATOM 7301 C CA . THR B 1 389 ? 17.939 18.981 5.217 1.00 36.13 ? 389 THR B CA 1 ATOM 7302 C C . THR B 1 389 ? 18.581 17.780 5.902 1.00 39.77 ? 389 THR B C 1 ATOM 7303 O O . THR B 1 389 ? 19.588 17.279 5.381 1.00 40.47 ? 389 THR B O 1 ATOM 7304 C CB . THR B 1 389 ? 17.981 20.236 6.090 1.00 38.98 ? 389 THR B CB 1 ATOM 7305 O OG1 . THR B 1 389 ? 17.518 21.352 5.334 1.00 43.71 ? 389 THR B OG1 1 ATOM 7306 C CG2 . THR B 1 389 ? 19.366 20.535 6.583 1.00 31.86 ? 389 THR B CG2 1 ATOM 7307 N N . THR B 1 390 ? 18.004 17.309 7.036 1.00 34.61 ? 390 THR B N 1 ATOM 7308 C CA . THR B 1 390 ? 18.556 16.181 7.790 1.00 33.92 ? 390 THR B CA 1 ATOM 7309 C C . THR B 1 390 ? 18.578 14.904 6.922 1.00 36.10 ? 390 THR B C 1 ATOM 7310 O O . THR B 1 390 ? 19.682 14.361 6.772 1.00 34.66 ? 390 THR B O 1 ATOM 7311 C CB . THR B 1 390 ? 17.899 16.030 9.167 1.00 39.89 ? 390 THR B CB 1 ATOM 7312 O OG1 . THR B 1 390 ? 18.415 17.079 9.984 1.00 39.08 ? 390 THR B OG1 1 ATOM 7313 C CG2 . THR B 1 390 ? 18.217 14.694 9.831 1.00 37.33 ? 390 THR B CG2 1 ATOM 7314 N N . PRO B 1 391 ? 17.457 14.449 6.280 1.00 32.61 ? 391 PRO B N 1 ATOM 7315 C CA . PRO B 1 391 ? 17.551 13.254 5.419 1.00 32.62 ? 391 PRO B CA 1 ATOM 7316 C C . PRO B 1 391 ? 18.647 13.342 4.355 1.00 37.83 ? 391 PRO B C 1 ATOM 7317 O O . PRO B 1 391 ? 19.376 12.366 4.181 1.00 37.84 ? 391 PRO B O 1 ATOM 7318 C CB . PRO B 1 391 ? 16.147 13.154 4.803 1.00 33.83 ? 391 PRO B CB 1 ATOM 7319 C CG . PRO B 1 391 ? 15.268 13.743 5.810 1.00 37.79 ? 391 PRO B CG 1 ATOM 7320 C CD . PRO B 1 391 ? 16.056 14.926 6.332 1.00 33.87 ? 391 PRO B CD 1 ATOM 7321 N N . LEU B 1 392 ? 18.806 14.516 3.703 1.00 34.92 ? 392 LEU B N 1 ATOM 7322 C CA . LEU B 1 392 ? 19.819 14.694 2.658 1.00 36.47 ? 392 LEU B CA 1 ATOM 7323 C C . LEU B 1 392 ? 21.258 14.695 3.188 1.00 39.65 ? 392 LEU B C 1 ATOM 7324 O O . LEU B 1 392 ? 22.152 14.189 2.510 1.00 38.30 ? 392 LEU B O 1 ATOM 7325 C CB . LEU B 1 392 ? 19.552 15.939 1.781 1.00 37.01 ? 392 LEU B CB 1 ATOM 7326 C CG . LEU B 1 392 ? 18.322 15.897 0.857 1.00 40.19 ? 392 LEU B CG 1 ATOM 7327 C CD1 . LEU B 1 392 ? 18.162 17.221 0.119 1.00 39.62 ? 392 LEU B CD1 1 ATOM 7328 C CD2 . LEU B 1 392 ? 18.366 14.701 -0.089 1.00 40.46 ? 392 LEU B CD2 1 ATOM 7329 N N . ALA B 1 393 ? 21.470 15.242 4.391 1.00 36.48 ? 393 ALA B N 1 ATOM 7330 C CA . ALA B 1 393 ? 22.768 15.256 5.061 1.00 36.66 ? 393 ALA B CA 1 ATOM 7331 C C . ALA B 1 393 ? 23.209 13.817 5.419 1.00 40.71 ? 393 ALA B C 1 ATOM 7332 O O . ALA B 1 393 ? 24.380 13.478 5.275 1.00 41.14 ? 393 ALA B O 1 ATOM 7333 C CB . ALA B 1 393 ? 22.684 16.106 6.322 1.00 37.54 ? 393 ALA B CB 1 ATOM 7334 N N . ARG B 1 394 ? 22.265 12.974 5.868 1.00 36.42 ? 394 ARG B N 1 ATOM 7335 C CA . ARG B 1 394 ? 22.521 11.582 6.244 1.00 35.66 ? 394 ARG B CA 1 ATOM 7336 C C . ARG B 1 394 ? 22.731 10.731 5.003 1.00 39.26 ? 394 ARG B C 1 ATOM 7337 O O . ARG B 1 394 ? 23.545 9.800 5.023 1.00 38.92 ? 394 ARG B O 1 ATOM 7338 C CB . ARG B 1 394 ? 21.383 11.023 7.123 1.00 34.86 ? 394 ARG B CB 1 ATOM 7339 C CG . ARG B 1 394 ? 21.244 11.790 8.429 1.00 38.18 ? 394 ARG B CG 1 ATOM 7340 C CD . ARG B 1 394 ? 20.374 11.129 9.453 1.00 37.02 ? 394 ARG B CD 1 ATOM 7341 N NE . ARG B 1 394 ? 20.257 11.986 10.635 1.00 44.56 ? 394 ARG B NE 1 ATOM 7342 C CZ . ARG B 1 394 ? 19.394 11.796 11.627 1.00 48.31 ? 394 ARG B CZ 1 ATOM 7343 N NH1 . ARG B 1 394 ? 18.561 10.763 11.604 1.00 22.31 ? 394 ARG B NH1 1 ATOM 7344 N NH2 . ARG B 1 394 ? 19.343 12.650 12.641 1.00 36.39 ? 394 ARG B NH2 1 ATOM 7345 N N . ALA B 1 395 ? 22.012 11.073 3.910 1.00 35.03 ? 395 ALA B N 1 ATOM 7346 C CA . ALA B 1 395 ? 22.114 10.419 2.609 1.00 34.56 ? 395 ALA B CA 1 ATOM 7347 C C . ALA B 1 395 ? 23.529 10.584 2.104 1.00 40.50 ? 395 ALA B C 1 ATOM 7348 O O . ALA B 1 395 ? 24.092 9.628 1.571 1.00 40.78 ? 395 ALA B O 1 ATOM 7349 C CB . ALA B 1 395 ? 21.151 11.056 1.638 1.00 35.31 ? 395 ALA B CB 1 ATOM 7350 N N . ALA B 1 396 ? 24.126 11.786 2.339 1.00 38.28 ? 396 ALA B N 1 ATOM 7351 C CA . ALA B 1 396 ? 25.508 12.127 1.995 1.00 38.31 ? 396 ALA B CA 1 ATOM 7352 C C . ALA B 1 396 ? 26.483 11.254 2.793 1.00 43.54 ? 396 ALA B C 1 ATOM 7353 O O . ALA B 1 396 ? 27.475 10.798 2.224 1.00 43.07 ? 396 ALA B O 1 ATOM 7354 C CB . ALA B 1 396 ? 25.774 13.599 2.257 1.00 38.86 ? 396 ALA B CB 1 ATOM 7355 N N . TRP B 1 397 ? 26.177 10.968 4.080 1.00 40.82 ? 397 TRP B N 1 ATOM 7356 C CA . TRP B 1 397 ? 27.029 10.095 4.896 1.00 41.30 ? 397 TRP B CA 1 ATOM 7357 C C . TRP B 1 397 ? 26.985 8.656 4.372 1.00 44.59 ? 397 TRP B C 1 ATOM 7358 O O . TRP B 1 397 ? 28.028 7.986 4.315 1.00 44.79 ? 397 TRP B O 1 ATOM 7359 C CB . TRP B 1 397 ? 26.653 10.136 6.396 1.00 40.36 ? 397 TRP B CB 1 ATOM 7360 C CG . TRP B 1 397 ? 27.741 9.607 7.289 1.00 41.40 ? 397 TRP B CG 1 ATOM 7361 C CD1 . TRP B 1 397 ? 28.059 8.299 7.511 1.00 44.19 ? 397 TRP B CD1 1 ATOM 7362 C CD2 . TRP B 1 397 ? 28.705 10.385 8.021 1.00 41.54 ? 397 TRP B CD2 1 ATOM 7363 N NE1 . TRP B 1 397 ? 29.164 8.210 8.331 1.00 43.59 ? 397 TRP B NE1 1 ATOM 7364 C CE2 . TRP B 1 397 ? 29.585 9.476 8.656 1.00 45.09 ? 397 TRP B CE2 1 ATOM 7365 C CE3 . TRP B 1 397 ? 28.915 11.765 8.197 1.00 42.86 ? 397 TRP B CE3 1 ATOM 7366 C CZ2 . TRP B 1 397 ? 30.649 9.900 9.461 1.00 44.36 ? 397 TRP B CZ2 1 ATOM 7367 C CZ3 . TRP B 1 397 ? 29.976 12.181 8.985 1.00 44.41 ? 397 TRP B CZ3 1 ATOM 7368 C CH2 . TRP B 1 397 ? 30.825 11.255 9.612 1.00 45.00 ? 397 TRP B CH2 1 ATOM 7369 N N . GLU B 1 398 ? 25.780 8.205 3.964 1.00 38.86 ? 398 GLU B N 1 ATOM 7370 C CA . GLU B 1 398 ? 25.527 6.859 3.448 1.00 37.79 ? 398 GLU B CA 1 ATOM 7371 C C . GLU B 1 398 ? 25.960 6.677 1.983 1.00 42.16 ? 398 GLU B C 1 ATOM 7372 O O . GLU B 1 398 ? 25.759 5.598 1.419 1.00 42.31 ? 398 GLU B O 1 ATOM 7373 C CB . GLU B 1 398 ? 24.059 6.468 3.669 1.00 38.57 ? 398 GLU B CB 1 ATOM 7374 C CG . GLU B 1 398 ? 23.752 6.158 5.123 1.00 42.06 ? 398 GLU B CG 1 ATOM 7375 C CD . GLU B 1 398 ? 22.317 6.342 5.572 1.00 43.33 ? 398 GLU B CD 1 ATOM 7376 O OE1 . GLU B 1 398 ? 21.512 6.906 4.805 1.00 32.51 ? 398 GLU B OE1 1 ATOM 7377 O OE2 . GLU B 1 398 ? 22.001 5.933 6.708 1.00 37.74 ? 398 GLU B OE2 1 ATOM 7378 N N . THR B 1 399 ? 26.564 7.723 1.375 1.00 38.37 ? 399 THR B N 1 ATOM 7379 C CA . THR B 1 399 ? 27.083 7.671 0.006 1.00 37.84 ? 399 THR B CA 1 ATOM 7380 C C . THR B 1 399 ? 28.529 7.143 0.051 1.00 42.97 ? 399 THR B C 1 ATOM 7381 O O . THR B 1 399 ? 28.981 6.502 -0.905 1.00 43.73 ? 399 THR B O 1 ATOM 7382 C CB . THR B 1 399 ? 27.012 9.063 -0.660 1.00 39.01 ? 399 THR B CB 1 ATOM 7383 O OG1 . THR B 1 399 ? 25.717 9.636 -0.484 1.00 36.96 ? 399 THR B OG1 1 ATOM 7384 C CG2 . THR B 1 399 ? 27.332 9.021 -2.150 1.00 31.66 ? 399 THR B CG2 1 ATOM 7385 N N . ALA B 1 400 ? 29.247 7.420 1.162 1.00 38.29 ? 400 ALA B N 1 ATOM 7386 C CA . ALA B 1 400 ? 30.644 7.054 1.352 1.00 37.88 ? 400 ALA B CA 1 ATOM 7387 C C . ALA B 1 400 ? 30.896 6.066 2.487 1.00 44.93 ? 400 ALA B C 1 ATOM 7388 O O . ALA B 1 400 ? 31.998 5.509 2.573 1.00 44.09 ? 400 ALA B O 1 ATOM 7389 C CB . ALA B 1 400 ? 31.464 8.306 1.568 1.00 38.28 ? 400 ALA B CB 1 ATOM 7390 N N . ARG B 1 401 ? 29.900 5.869 3.383 1.00 44.14 ? 401 ARG B N 1 ATOM 7391 C CA . ARG B 1 401 ? 30.013 4.958 4.535 1.00 43.45 ? 401 ARG B CA 1 ATOM 7392 C C . ARG B 1 401 ? 28.813 4.057 4.666 1.00 50.25 ? 401 ARG B C 1 ATOM 7393 O O . ARG B 1 401 ? 27.680 4.526 4.562 1.00 49.40 ? 401 ARG B O 1 ATOM 7394 C CB . ARG B 1 401 ? 30.185 5.739 5.848 1.00 38.94 ? 401 ARG B CB 1 ATOM 7395 C CG . ARG B 1 401 ? 31.465 6.545 5.961 1.00 39.69 ? 401 ARG B CG 1 ATOM 7396 C CD . ARG B 1 401 ? 32.661 5.764 6.452 1.00 50.41 ? 401 ARG B CD 1 ATOM 7397 N NE . ARG B 1 401 ? 33.851 6.615 6.509 1.00 61.73 ? 401 ARG B NE 1 ATOM 7398 C CZ . ARG B 1 401 ? 34.938 6.451 5.762 1.00 78.97 ? 401 ARG B CZ 1 ATOM 7399 N NH1 . ARG B 1 401 ? 35.019 5.438 4.907 1.00 68.92 ? 401 ARG B NH1 1 ATOM 7400 N NH2 . ARG B 1 401 ? 35.962 7.282 5.881 1.00 67.03 ? 401 ARG B NH2 1 ATOM 7401 N N . HIS B 1 402 ? 29.062 2.765 4.924 1.00 50.54 ? 402 HIS B N 1 ATOM 7402 C CA . HIS B 1 402 ? 28.007 1.775 5.160 1.00 51.55 ? 402 HIS B CA 1 ATOM 7403 C C . HIS B 1 402 ? 27.617 1.820 6.640 1.00 56.01 ? 402 HIS B C 1 ATOM 7404 O O . HIS B 1 402 ? 28.465 1.611 7.502 1.00 55.48 ? 402 HIS B O 1 ATOM 7405 C CB . HIS B 1 402 ? 28.450 0.359 4.746 1.00 52.30 ? 402 HIS B CB 1 ATOM 7406 C CG . HIS B 1 402 ? 28.429 0.141 3.270 1.00 55.94 ? 402 HIS B CG 1 ATOM 7407 N ND1 . HIS B 1 402 ? 29.506 0.483 2.479 1.00 58.24 ? 402 HIS B ND1 1 ATOM 7408 C CD2 . HIS B 1 402 ? 27.460 -0.379 2.485 1.00 57.90 ? 402 HIS B CD2 1 ATOM 7409 C CE1 . HIS B 1 402 ? 29.156 0.177 1.241 1.00 57.58 ? 402 HIS B CE1 1 ATOM 7410 N NE2 . HIS B 1 402 ? 27.938 -0.357 1.197 1.00 57.81 ? 402 HIS B NE2 1 ATOM 7411 N N . THR B 1 403 ? 26.349 2.144 6.920 1.00 53.27 ? 403 THR B N 1 ATOM 7412 C CA . THR B 1 403 ? 25.801 2.240 8.273 1.00 53.52 ? 403 THR B CA 1 ATOM 7413 C C . THR B 1 403 ? 24.899 1.032 8.567 1.00 57.07 ? 403 THR B C 1 ATOM 7414 O O . THR B 1 403 ? 24.419 0.404 7.616 1.00 55.95 ? 403 THR B O 1 ATOM 7415 C CB . THR B 1 403 ? 25.066 3.584 8.466 1.00 67.00 ? 403 THR B CB 1 ATOM 7416 O OG1 . THR B 1 403 ? 23.996 3.691 7.519 1.00 67.38 ? 403 THR B OG1 1 ATOM 7417 C CG2 . THR B 1 403 ? 26.012 4.803 8.381 1.00 67.56 ? 403 THR B CG2 1 ATOM 7418 N N . PRO B 1 404 ? 24.647 0.667 9.856 1.00 53.92 ? 404 PRO B N 1 ATOM 7419 C CA . PRO B 1 404 ? 23.764 -0.484 10.112 1.00 53.60 ? 404 PRO B CA 1 ATOM 7420 C C . PRO B 1 404 ? 22.301 -0.137 9.843 1.00 58.86 ? 404 PRO B C 1 ATOM 7421 O O . PRO B 1 404 ? 21.493 -1.039 9.613 1.00 59.56 ? 404 PRO B O 1 ATOM 7422 C CB . PRO B 1 404 ? 24.034 -0.824 11.575 1.00 55.03 ? 404 PRO B CB 1 ATOM 7423 C CG . PRO B 1 404 ? 24.463 0.459 12.190 1.00 59.33 ? 404 PRO B CG 1 ATOM 7424 C CD . PRO B 1 404 ? 25.127 1.274 11.119 1.00 55.18 ? 404 PRO B CD 1 ATOM 7425 N N . VAL B 1 405 ? 21.982 1.178 9.840 1.00 54.57 ? 405 VAL B N 1 ATOM 7426 C CA . VAL B 1 405 ? 20.666 1.769 9.583 1.00 53.94 ? 405 VAL B CA 1 ATOM 7427 C C . VAL B 1 405 ? 20.722 2.605 8.302 1.00 56.27 ? 405 VAL B C 1 ATOM 7428 O O . VAL B 1 405 ? 21.419 3.615 8.250 1.00 56.52 ? 405 VAL B O 1 ATOM 7429 C CB . VAL B 1 405 ? 20.143 2.580 10.805 1.00 58.41 ? 405 VAL B CB 1 ATOM 7430 C CG1 . VAL B 1 405 ? 21.146 3.631 11.296 1.00 58.42 ? 405 VAL B CG1 1 ATOM 7431 C CG2 . VAL B 1 405 ? 18.803 3.240 10.518 1.00 58.48 ? 405 VAL B CG2 1 ATOM 7432 N N . ASN B 1 406 ? 20.020 2.175 7.256 1.00 50.21 ? 406 ASN B N 1 ATOM 7433 C CA . ASN B 1 406 ? 20.050 2.944 6.023 1.00 48.45 ? 406 ASN B CA 1 ATOM 7434 C C . ASN B 1 406 ? 18.922 3.949 6.042 1.00 47.78 ? 406 ASN B C 1 ATOM 7435 O O . ASN B 1 406 ? 17.786 3.619 5.699 1.00 47.21 ? 406 ASN B O 1 ATOM 7436 C CB . ASN B 1 406 ? 20.054 2.036 4.793 1.00 49.00 ? 406 ASN B CB 1 ATOM 7437 C CG . ASN B 1 406 ? 21.273 1.145 4.757 1.00 59.96 ? 406 ASN B CG 1 ATOM 7438 O OD1 . ASN B 1 406 ? 22.363 1.558 4.337 1.00 54.09 ? 406 ASN B OD1 1 ATOM 7439 N ND2 . ASN B 1 406 ? 21.136 -0.069 5.277 1.00 42.76 ? 406 ASN B ND2 1 ATOM 7440 N N . SER B 1 407 ? 19.242 5.175 6.506 1.00 41.27 ? 407 SER B N 1 ATOM 7441 C CA . SER B 1 407 ? 18.292 6.289 6.636 1.00 39.97 ? 407 SER B CA 1 ATOM 7442 C C . SER B 1 407 ? 17.647 6.634 5.311 1.00 44.58 ? 407 SER B C 1 ATOM 7443 O O . SER B 1 407 ? 16.436 6.840 5.288 1.00 46.32 ? 407 SER B O 1 ATOM 7444 C CB . SER B 1 407 ? 18.953 7.518 7.253 1.00 40.89 ? 407 SER B CB 1 ATOM 7445 O OG . SER B 1 407 ? 19.723 8.247 6.317 1.00 42.23 ? 407 SER B OG 1 ATOM 7446 N N . TRP B 1 408 ? 18.439 6.635 4.200 1.00 37.74 ? 408 TRP B N 1 ATOM 7447 C CA . TRP B 1 408 ? 17.959 6.883 2.847 1.00 36.46 ? 408 TRP B CA 1 ATOM 7448 C C . TRP B 1 408 ? 16.885 5.866 2.454 1.00 43.67 ? 408 TRP B C 1 ATOM 7449 O O . TRP B 1 408 ? 16.039 6.174 1.615 1.00 45.76 ? 408 TRP B O 1 ATOM 7450 C CB . TRP B 1 408 ? 19.115 6.854 1.831 1.00 34.38 ? 408 TRP B CB 1 ATOM 7451 C CG . TRP B 1 408 ? 19.805 5.526 1.699 1.00 35.22 ? 408 TRP B CG 1 ATOM 7452 C CD1 . TRP B 1 408 ? 20.898 5.100 2.395 1.00 38.06 ? 408 TRP B CD1 1 ATOM 7453 C CD2 . TRP B 1 408 ? 19.415 4.429 0.854 1.00 35.07 ? 408 TRP B CD2 1 ATOM 7454 N NE1 . TRP B 1 408 ? 21.210 3.807 2.045 1.00 37.46 ? 408 TRP B NE1 1 ATOM 7455 C CE2 . TRP B 1 408 ? 20.312 3.368 1.104 1.00 39.08 ? 408 TRP B CE2 1 ATOM 7456 C CE3 . TRP B 1 408 ? 18.358 4.217 -0.049 1.00 36.44 ? 408 TRP B CE3 1 ATOM 7457 C CZ2 . TRP B 1 408 ? 20.215 2.134 0.443 1.00 38.71 ? 408 TRP B CZ2 1 ATOM 7458 C CZ3 . TRP B 1 408 ? 18.263 2.996 -0.705 1.00 37.95 ? 408 TRP B CZ3 1 ATOM 7459 C CH2 . TRP B 1 408 ? 19.188 1.974 -0.465 1.00 38.63 ? 408 TRP B CH2 1 ATOM 7460 N N . LEU B 1 409 ? 16.950 4.638 3.010 1.00 39.27 ? 409 LEU B N 1 ATOM 7461 C CA . LEU B 1 409 ? 15.969 3.604 2.679 1.00 38.52 ? 409 LEU B CA 1 ATOM 7462 C C . LEU B 1 409 ? 14.677 3.834 3.454 1.00 39.93 ? 409 LEU B C 1 ATOM 7463 O O . LEU B 1 409 ? 13.605 3.720 2.878 1.00 39.64 ? 409 LEU B O 1 ATOM 7464 C CB . LEU B 1 409 ? 16.547 2.182 2.862 1.00 38.52 ? 409 LEU B CB 1 ATOM 7465 C CG . LEU B 1 409 ? 15.664 0.972 2.496 1.00 42.01 ? 409 LEU B CG 1 ATOM 7466 C CD1 . LEU B 1 409 ? 15.071 1.090 1.102 1.00 41.14 ? 409 LEU B CD1 1 ATOM 7467 C CD2 . LEU B 1 409 ? 16.445 -0.316 2.633 1.00 43.92 ? 409 LEU B CD2 1 ATOM 7468 N N . GLY B 1 410 ? 14.794 4.216 4.720 1.00 34.80 ? 410 GLY B N 1 ATOM 7469 C CA . GLY B 1 410 ? 13.645 4.543 5.549 1.00 34.42 ? 410 GLY B CA 1 ATOM 7470 C C . GLY B 1 410 ? 12.950 5.809 5.076 1.00 37.66 ? 410 GLY B C 1 ATOM 7471 O O . GLY B 1 410 ? 11.718 5.885 5.096 1.00 37.87 ? 410 GLY B O 1 ATOM 7472 N N . ASN B 1 411 ? 13.738 6.800 4.612 1.00 32.46 ? 411 ASN B N 1 ATOM 7473 C CA . ASN B 1 411 ? 13.228 8.063 4.106 1.00 32.65 ? 411 ASN B CA 1 ATOM 7474 C C . ASN B 1 411 ? 12.471 7.882 2.804 1.00 40.46 ? 411 ASN B C 1 ATOM 7475 O O . ASN B 1 411 ? 11.471 8.569 2.601 1.00 41.54 ? 411 ASN B O 1 ATOM 7476 C CB . ASN B 1 411 ? 14.332 9.107 3.979 1.00 33.37 ? 411 ASN B CB 1 ATOM 7477 C CG . ASN B 1 411 ? 14.780 9.705 5.302 1.00 45.97 ? 411 ASN B CG 1 ATOM 7478 O OD1 . ASN B 1 411 ? 13.976 10.064 6.192 1.00 28.20 ? 411 ASN B OD1 1 ATOM 7479 N ND2 . ASN B 1 411 ? 16.084 9.854 5.442 1.00 37.49 ? 411 ASN B ND2 1 ATOM 7480 N N . ILE B 1 412 ? 12.931 6.945 1.930 1.00 37.76 ? 412 ILE B N 1 ATOM 7481 C CA . ILE B 1 412 ? 12.271 6.561 0.677 1.00 37.17 ? 412 ILE B CA 1 ATOM 7482 C C . ILE B 1 412 ? 10.919 5.909 1.033 1.00 41.85 ? 412 ILE B C 1 ATOM 7483 O O . ILE B 1 412 ? 9.914 6.205 0.396 1.00 42.62 ? 412 ILE B O 1 ATOM 7484 C CB . ILE B 1 412 ? 13.173 5.608 -0.164 1.00 40.20 ? 412 ILE B CB 1 ATOM 7485 C CG1 . ILE B 1 412 ? 14.149 6.404 -1.042 1.00 40.71 ? 412 ILE B CG1 1 ATOM 7486 C CG2 . ILE B 1 412 ? 12.341 4.648 -1.033 1.00 41.79 ? 412 ILE B CG2 1 ATOM 7487 C CD1 . ILE B 1 412 ? 15.343 5.591 -1.617 1.00 46.09 ? 412 ILE B CD1 1 ATOM 7488 N N . ILE B 1 413 ? 10.905 5.039 2.054 1.00 37.43 ? 413 ILE B N 1 ATOM 7489 C CA . ILE B 1 413 ? 9.719 4.321 2.511 1.00 37.12 ? 413 ILE B CA 1 ATOM 7490 C C . ILE B 1 413 ? 8.666 5.267 3.147 1.00 40.30 ? 413 ILE B C 1 ATOM 7491 O O . ILE B 1 413 ? 7.517 5.309 2.717 1.00 40.18 ? 413 ILE B O 1 ATOM 7492 C CB . ILE B 1 413 ? 10.137 3.142 3.457 1.00 39.90 ? 413 ILE B CB 1 ATOM 7493 C CG1 . ILE B 1 413 ? 10.867 2.025 2.680 1.00 38.95 ? 413 ILE B CG1 1 ATOM 7494 C CG2 . ILE B 1 413 ? 8.927 2.566 4.217 1.00 41.21 ? 413 ILE B CG2 1 ATOM 7495 C CD1 . ILE B 1 413 ? 11.830 1.191 3.482 1.00 35.82 ? 413 ILE B CD1 1 ATOM 7496 N N . MET B 1 414 ? 9.067 6.009 4.162 1.00 36.13 ? 414 MET B N 1 ATOM 7497 C CA . MET B 1 414 ? 8.175 6.870 4.930 1.00 34.95 ? 414 MET B CA 1 ATOM 7498 C C . MET B 1 414 ? 7.753 8.139 4.196 1.00 37.80 ? 414 MET B C 1 ATOM 7499 O O . MET B 1 414 ? 6.657 8.653 4.459 1.00 36.42 ? 414 MET B O 1 ATOM 7500 C CB . MET B 1 414 ? 8.806 7.179 6.298 1.00 36.78 ? 414 MET B CB 1 ATOM 7501 C CG . MET B 1 414 ? 9.160 5.909 7.078 1.00 40.46 ? 414 MET B CG 1 ATOM 7502 S SD . MET B 1 414 ? 7.789 4.695 7.176 1.00 44.68 ? 414 MET B SD 1 ATOM 7503 C CE . MET B 1 414 ? 7.008 5.209 8.650 1.00 41.57 ? 414 MET B CE 1 ATOM 7504 N N . TYR B 1 415 ? 8.597 8.620 3.254 1.00 34.30 ? 415 TYR B N 1 ATOM 7505 C CA . TYR B 1 415 ? 8.340 9.847 2.492 1.00 33.43 ? 415 TYR B CA 1 ATOM 7506 C C . TYR B 1 415 ? 8.303 9.621 0.993 1.00 35.74 ? 415 TYR B C 1 ATOM 7507 O O . TYR B 1 415 ? 8.637 10.521 0.226 1.00 35.63 ? 415 TYR B O 1 ATOM 7508 C CB . TYR B 1 415 ? 9.338 10.963 2.871 1.00 33.68 ? 415 TYR B CB 1 ATOM 7509 C CG . TYR B 1 415 ? 9.329 11.321 4.335 1.00 33.94 ? 415 TYR B CG 1 ATOM 7510 C CD1 . TYR B 1 415 ? 8.321 12.119 4.871 1.00 36.08 ? 415 TYR B CD1 1 ATOM 7511 C CD2 . TYR B 1 415 ? 10.315 10.847 5.192 1.00 34.38 ? 415 TYR B CD2 1 ATOM 7512 C CE1 . TYR B 1 415 ? 8.288 12.426 6.231 1.00 36.73 ? 415 TYR B CE1 1 ATOM 7513 C CE2 . TYR B 1 415 ? 10.314 11.176 6.545 1.00 35.15 ? 415 TYR B CE2 1 ATOM 7514 C CZ . TYR B 1 415 ? 9.291 11.958 7.064 1.00 39.47 ? 415 TYR B CZ 1 ATOM 7515 O OH . TYR B 1 415 ? 9.283 12.291 8.395 1.00 32.99 ? 415 TYR B OH 1 ATOM 7516 N N . ALA B 1 416 ? 7.839 8.443 0.578 1.00 31.89 ? 416 ALA B N 1 ATOM 7517 C CA . ALA B 1 416 ? 7.698 8.072 -0.829 1.00 31.79 ? 416 ALA B CA 1 ATOM 7518 C C . ALA B 1 416 ? 6.900 9.061 -1.687 1.00 37.45 ? 416 ALA B C 1 ATOM 7519 O O . ALA B 1 416 ? 7.346 9.292 -2.800 1.00 36.11 ? 416 ALA B O 1 ATOM 7520 C CB . ALA B 1 416 ? 7.101 6.693 -0.946 1.00 32.12 ? 416 ALA B CB 1 ATOM 7521 N N . PRO B 1 417 ? 5.769 9.687 -1.251 1.00 36.47 ? 417 PRO B N 1 ATOM 7522 C CA . PRO B 1 417 ? 5.060 10.597 -2.176 1.00 37.17 ? 417 PRO B CA 1 ATOM 7523 C C . PRO B 1 417 ? 5.607 12.024 -2.238 1.00 43.29 ? 417 PRO B C 1 ATOM 7524 O O . PRO B 1 417 ? 5.040 12.864 -2.943 1.00 44.22 ? 417 PRO B O 1 ATOM 7525 C CB . PRO B 1 417 ? 3.609 10.546 -1.689 1.00 38.70 ? 417 PRO B CB 1 ATOM 7526 C CG . PRO B 1 417 ? 3.709 10.219 -0.235 1.00 42.68 ? 417 PRO B CG 1 ATOM 7527 C CD . PRO B 1 417 ? 5.037 9.563 0.032 1.00 38.04 ? 417 PRO B CD 1 ATOM 7528 N N . THR B 1 418 ? 6.710 12.298 -1.526 1.00 40.02 ? 418 THR B N 1 ATOM 7529 C CA . THR B 1 418 ? 7.309 13.631 -1.506 1.00 40.02 ? 418 THR B CA 1 ATOM 7530 C C . THR B 1 418 ? 8.123 13.872 -2.757 1.00 45.22 ? 418 THR B C 1 ATOM 7531 O O . THR B 1 418 ? 8.613 12.929 -3.380 1.00 44.94 ? 418 THR B O 1 ATOM 7532 C CB . THR B 1 418 ? 8.142 13.887 -0.226 1.00 43.28 ? 418 THR B CB 1 ATOM 7533 O OG1 . THR B 1 418 ? 9.355 13.133 -0.265 1.00 39.67 ? 418 THR B OG1 1 ATOM 7534 C CG2 . THR B 1 418 ? 7.382 13.605 1.042 1.00 39.37 ? 418 THR B CG2 1 ATOM 7535 N N . LEU B 1 419 ? 8.278 15.148 -3.102 1.00 42.23 ? 419 LEU B N 1 ATOM 7536 C CA . LEU B 1 419 ? 9.038 15.650 -4.234 1.00 41.65 ? 419 LEU B CA 1 ATOM 7537 C C . LEU B 1 419 ? 10.521 15.196 -4.093 1.00 42.92 ? 419 LEU B C 1 ATOM 7538 O O . LEU B 1 419 ? 11.018 14.471 -4.957 1.00 42.00 ? 419 LEU B O 1 ATOM 7539 C CB . LEU B 1 419 ? 8.877 17.189 -4.230 1.00 42.00 ? 419 LEU B CB 1 ATOM 7540 C CG . LEU B 1 419 ? 9.690 18.019 -5.215 1.00 47.39 ? 419 LEU B CG 1 ATOM 7541 C CD1 . LEU B 1 419 ? 8.929 18.240 -6.493 1.00 48.33 ? 419 LEU B CD1 1 ATOM 7542 C CD2 . LEU B 1 419 ? 10.053 19.344 -4.619 1.00 48.26 ? 419 LEU B CD2 1 ATOM 7543 N N . TRP B 1 420 ? 11.159 15.531 -2.952 1.00 38.44 ? 420 TRP B N 1 ATOM 7544 C CA . TRP B 1 420 ? 12.567 15.262 -2.613 1.00 38.55 ? 420 TRP B CA 1 ATOM 7545 C C . TRP B 1 420 ? 12.981 13.767 -2.526 1.00 41.33 ? 420 TRP B C 1 ATOM 7546 O O . TRP B 1 420 ? 14.064 13.415 -3.026 1.00 39.90 ? 420 TRP B O 1 ATOM 7547 C CB . TRP B 1 420 ? 12.951 15.983 -1.311 1.00 37.65 ? 420 TRP B CB 1 ATOM 7548 C CG . TRP B 1 420 ? 12.063 15.682 -0.130 1.00 39.13 ? 420 TRP B CG 1 ATOM 7549 C CD1 . TRP B 1 420 ? 10.879 16.290 0.189 1.00 42.11 ? 420 TRP B CD1 1 ATOM 7550 C CD2 . TRP B 1 420 ? 12.320 14.730 0.916 1.00 39.11 ? 420 TRP B CD2 1 ATOM 7551 N NE1 . TRP B 1 420 ? 10.369 15.758 1.355 1.00 41.49 ? 420 TRP B NE1 1 ATOM 7552 C CE2 . TRP B 1 420 ? 11.231 14.797 1.821 1.00 42.91 ? 420 TRP B CE2 1 ATOM 7553 C CE3 . TRP B 1 420 ? 13.361 13.812 1.170 1.00 40.18 ? 420 TRP B CE3 1 ATOM 7554 C CZ2 . TRP B 1 420 ? 11.162 13.996 2.964 1.00 42.14 ? 420 TRP B CZ2 1 ATOM 7555 C CZ3 . TRP B 1 420 ? 13.291 13.026 2.309 1.00 41.61 ? 420 TRP B CZ3 1 ATOM 7556 C CH2 . TRP B 1 420 ? 12.207 13.125 3.194 1.00 42.24 ? 420 TRP B CH2 1 ATOM 7557 N N . ALA B 1 421 ? 12.155 12.902 -1.873 1.00 35.83 ? 421 ALA B N 1 ATOM 7558 C CA . ALA B 1 421 ? 12.494 11.483 -1.726 1.00 34.34 ? 421 ALA B CA 1 ATOM 7559 C C . ALA B 1 421 ? 12.449 10.765 -3.050 1.00 37.14 ? 421 ALA B C 1 ATOM 7560 O O . ALA B 1 421 ? 13.235 9.844 -3.286 1.00 36.50 ? 421 ALA B O 1 ATOM 7561 C CB . ALA B 1 421 ? 11.569 10.809 -0.731 1.00 34.75 ? 421 ALA B CB 1 ATOM 7562 N N . ARG B 1 422 ? 11.528 11.198 -3.919 1.00 33.55 ? 422 ARG B N 1 ATOM 7563 C CA . ARG B 1 422 ? 11.319 10.626 -5.241 1.00 32.70 ? 422 ARG B CA 1 ATOM 7564 C C . ARG B 1 422 ? 12.390 11.094 -6.195 1.00 35.72 ? 422 ARG B C 1 ATOM 7565 O O . ARG B 1 422 ? 12.977 10.273 -6.892 1.00 35.26 ? 422 ARG B O 1 ATOM 7566 C CB . ARG B 1 422 ? 9.958 11.054 -5.788 1.00 31.08 ? 422 ARG B CB 1 ATOM 7567 C CG . ARG B 1 422 ? 8.793 10.292 -5.223 1.00 38.97 ? 422 ARG B CG 1 ATOM 7568 C CD . ARG B 1 422 ? 7.474 10.881 -5.706 1.00 44.53 ? 422 ARG B CD 1 ATOM 7569 N NE . ARG B 1 422 ? 7.039 10.319 -6.987 1.00 42.39 ? 422 ARG B NE 1 ATOM 7570 C CZ . ARG B 1 422 ? 6.092 10.850 -7.753 1.00 56.87 ? 422 ARG B CZ 1 ATOM 7571 N NH1 . ARG B 1 422 ? 5.482 11.968 -7.388 1.00 47.99 ? 422 ARG B NH1 1 ATOM 7572 N NH2 . ARG B 1 422 ? 5.753 10.270 -8.896 1.00 45.78 ? 422 ARG B NH2 1 ATOM 7573 N N . MET B 1 423 ? 12.633 12.417 -6.243 1.00 31.79 ? 423 MET B N 1 ATOM 7574 C CA . MET B 1 423 ? 13.562 13.006 -7.196 1.00 31.04 ? 423 MET B CA 1 ATOM 7575 C C . MET B 1 423 ? 15.011 12.791 -6.864 1.00 35.64 ? 423 MET B C 1 ATOM 7576 O O . MET B 1 423 ? 15.770 12.393 -7.749 1.00 35.89 ? 423 MET B O 1 ATOM 7577 C CB . MET B 1 423 ? 13.270 14.490 -7.428 1.00 33.02 ? 423 MET B CB 1 ATOM 7578 C CG . MET B 1 423 ? 11.987 14.713 -8.202 1.00 36.56 ? 423 MET B CG 1 ATOM 7579 S SD . MET B 1 423 ? 11.817 16.394 -8.801 1.00 41.04 ? 423 MET B SD 1 ATOM 7580 C CE . MET B 1 423 ? 12.694 16.292 -10.325 1.00 36.77 ? 423 MET B CE 1 ATOM 7581 N N . ILE B 1 424 ? 15.412 13.051 -5.609 1.00 31.69 ? 424 ILE B N 1 ATOM 7582 C CA . ILE B 1 424 ? 16.807 12.939 -5.202 1.00 29.83 ? 424 ILE B CA 1 ATOM 7583 C C . ILE B 1 424 ? 17.150 11.584 -4.639 1.00 34.25 ? 424 ILE B C 1 ATOM 7584 O O . ILE B 1 424 ? 18.032 10.922 -5.159 1.00 34.57 ? 424 ILE B O 1 ATOM 7585 C CB . ILE B 1 424 ? 17.204 14.082 -4.237 1.00 32.30 ? 424 ILE B CB 1 ATOM 7586 C CG1 . ILE B 1 424 ? 17.030 15.456 -4.914 1.00 33.27 ? 424 ILE B CG1 1 ATOM 7587 C CG2 . ILE B 1 424 ? 18.635 13.902 -3.759 1.00 32.16 ? 424 ILE B CG2 1 ATOM 7588 C CD1 . ILE B 1 424 ? 16.385 16.495 -4.102 1.00 42.14 ? 424 ILE B CD1 1 ATOM 7589 N N . LEU B 1 425 ? 16.491 11.176 -3.560 1.00 32.16 ? 425 LEU B N 1 ATOM 7590 C CA . LEU B 1 425 ? 16.864 9.967 -2.835 1.00 31.28 ? 425 LEU B CA 1 ATOM 7591 C C . LEU B 1 425 ? 16.738 8.690 -3.649 1.00 35.19 ? 425 LEU B C 1 ATOM 7592 O O . LEU B 1 425 ? 17.733 7.965 -3.739 1.00 34.19 ? 425 LEU B O 1 ATOM 7593 C CB . LEU B 1 425 ? 16.129 9.876 -1.488 1.00 30.61 ? 425 LEU B CB 1 ATOM 7594 C CG . LEU B 1 425 ? 16.633 10.882 -0.435 1.00 34.07 ? 425 LEU B CG 1 ATOM 7595 C CD1 . LEU B 1 425 ? 15.738 10.906 0.776 1.00 34.32 ? 425 LEU B CD1 1 ATOM 7596 C CD2 . LEU B 1 425 ? 18.077 10.602 -0.032 1.00 34.36 ? 425 LEU B CD2 1 ATOM 7597 N N . MET B 1 426 ? 15.564 8.442 -4.274 1.00 31.73 ? 426 MET B N 1 ATOM 7598 C CA . MET B 1 426 ? 15.316 7.254 -5.096 1.00 30.84 ? 426 MET B CA 1 ATOM 7599 C C . MET B 1 426 ? 16.302 7.165 -6.237 1.00 36.95 ? 426 MET B C 1 ATOM 7600 O O . MET B 1 426 ? 16.898 6.109 -6.429 1.00 37.28 ? 426 MET B O 1 ATOM 7601 C CB . MET B 1 426 ? 13.872 7.235 -5.637 1.00 32.50 ? 426 MET B CB 1 ATOM 7602 C CG . MET B 1 426 ? 12.867 6.731 -4.625 1.00 35.17 ? 426 MET B CG 1 ATOM 7603 S SD . MET B 1 426 ? 11.209 6.617 -5.274 1.00 38.32 ? 426 MET B SD 1 ATOM 7604 C CE . MET B 1 426 ? 10.297 6.529 -3.818 1.00 34.92 ? 426 MET B CE 1 ATOM 7605 N N . THR B 1 427 ? 16.502 8.289 -6.972 1.00 33.84 ? 427 THR B N 1 ATOM 7606 C CA . THR B 1 427 ? 17.409 8.412 -8.119 1.00 33.34 ? 427 THR B CA 1 ATOM 7607 C C . THR B 1 427 ? 18.853 8.085 -7.744 1.00 38.76 ? 427 THR B C 1 ATOM 7608 O O . THR B 1 427 ? 19.432 7.157 -8.305 1.00 39.49 ? 427 THR B O 1 ATOM 7609 C CB . THR B 1 427 ? 17.265 9.802 -8.723 1.00 37.49 ? 427 THR B CB 1 ATOM 7610 O OG1 . THR B 1 427 ? 15.900 9.994 -9.062 1.00 37.52 ? 427 THR B OG1 1 ATOM 7611 C CG2 . THR B 1 427 ? 18.142 10.016 -9.943 1.00 37.93 ? 427 THR B CG2 1 ATOM 7612 N N . HIS B 1 428 ? 19.418 8.848 -6.793 1.00 34.50 ? 428 HIS B N 1 ATOM 7613 C CA . HIS B 1 428 ? 20.784 8.716 -6.312 1.00 34.04 ? 428 HIS B CA 1 ATOM 7614 C C . HIS B 1 428 ? 21.116 7.295 -5.895 1.00 37.64 ? 428 HIS B C 1 ATOM 7615 O O . HIS B 1 428 ? 22.036 6.684 -6.439 1.00 38.45 ? 428 HIS B O 1 ATOM 7616 C CB . HIS B 1 428 ? 21.018 9.690 -5.141 1.00 34.58 ? 428 HIS B CB 1 ATOM 7617 C CG . HIS B 1 428 ? 22.397 9.664 -4.565 1.00 37.90 ? 428 HIS B CG 1 ATOM 7618 N ND1 . HIS B 1 428 ? 23.497 10.101 -5.290 1.00 39.81 ? 428 HIS B ND1 1 ATOM 7619 C CD2 . HIS B 1 428 ? 22.802 9.315 -3.323 1.00 39.65 ? 428 HIS B CD2 1 ATOM 7620 C CE1 . HIS B 1 428 ? 24.533 9.977 -4.477 1.00 39.37 ? 428 HIS B CE1 1 ATOM 7621 N NE2 . HIS B 1 428 ? 24.161 9.520 -3.275 1.00 39.65 ? 428 HIS B NE2 1 ATOM 7622 N N . PHE B 1 429 ? 20.350 6.764 -4.957 1.00 32.41 ? 429 PHE B N 1 ATOM 7623 C CA . PHE B 1 429 ? 20.626 5.464 -4.401 1.00 31.28 ? 429 PHE B CA 1 ATOM 7624 C C . PHE B 1 429 ? 20.354 4.331 -5.369 1.00 35.65 ? 429 PHE B C 1 ATOM 7625 O O . PHE B 1 429 ? 21.128 3.375 -5.354 1.00 35.63 ? 429 PHE B O 1 ATOM 7626 C CB . PHE B 1 429 ? 19.933 5.291 -3.052 1.00 32.24 ? 429 PHE B CB 1 ATOM 7627 C CG . PHE B 1 429 ? 20.664 6.100 -2.006 1.00 33.26 ? 429 PHE B CG 1 ATOM 7628 C CD1 . PHE B 1 429 ? 21.864 5.640 -1.457 1.00 35.40 ? 429 PHE B CD1 1 ATOM 7629 C CD2 . PHE B 1 429 ? 20.213 7.369 -1.642 1.00 35.52 ? 429 PHE B CD2 1 ATOM 7630 C CE1 . PHE B 1 429 ? 22.575 6.413 -0.522 1.00 35.87 ? 429 PHE B CE1 1 ATOM 7631 C CE2 . PHE B 1 429 ? 20.936 8.152 -0.721 1.00 37.89 ? 429 PHE B CE2 1 ATOM 7632 C CZ . PHE B 1 429 ? 22.106 7.661 -0.159 1.00 35.34 ? 429 PHE B CZ 1 ATOM 7633 N N . PHE B 1 430 ? 19.363 4.445 -6.266 1.00 31.94 ? 430 PHE B N 1 ATOM 7634 C CA . PHE B 1 430 ? 19.174 3.369 -7.233 1.00 32.10 ? 430 PHE B CA 1 ATOM 7635 C C . PHE B 1 430 ? 20.298 3.331 -8.273 1.00 35.57 ? 430 PHE B C 1 ATOM 7636 O O . PHE B 1 430 ? 20.706 2.228 -8.655 1.00 34.88 ? 430 PHE B O 1 ATOM 7637 C CB . PHE B 1 430 ? 17.791 3.364 -7.871 1.00 34.57 ? 430 PHE B CB 1 ATOM 7638 C CG . PHE B 1 430 ? 16.809 2.481 -7.132 1.00 36.83 ? 430 PHE B CG 1 ATOM 7639 C CD1 . PHE B 1 430 ? 15.955 3.012 -6.172 1.00 39.76 ? 430 PHE B CD1 1 ATOM 7640 C CD2 . PHE B 1 430 ? 16.729 1.120 -7.404 1.00 38.88 ? 430 PHE B CD2 1 ATOM 7641 C CE1 . PHE B 1 430 ? 15.046 2.200 -5.500 1.00 40.17 ? 430 PHE B CE1 1 ATOM 7642 C CE2 . PHE B 1 430 ? 15.828 0.305 -6.712 1.00 41.41 ? 430 PHE B CE2 1 ATOM 7643 C CZ . PHE B 1 430 ? 14.984 0.853 -5.778 1.00 39.22 ? 430 PHE B CZ 1 ATOM 7644 N N . SER B 1 431 ? 20.883 4.494 -8.637 1.00 32.41 ? 431 SER B N 1 ATOM 7645 C CA . SER B 1 431 ? 22.025 4.485 -9.554 1.00 33.51 ? 431 SER B CA 1 ATOM 7646 C C . SER B 1 431 ? 23.224 3.798 -8.894 1.00 39.87 ? 431 SER B C 1 ATOM 7647 O O . SER B 1 431 ? 23.924 3.048 -9.568 1.00 40.59 ? 431 SER B O 1 ATOM 7648 C CB . SER B 1 431 ? 22.387 5.883 -10.039 1.00 37.42 ? 431 SER B CB 1 ATOM 7649 O OG . SER B 1 431 ? 23.066 6.642 -9.056 1.00 49.87 ? 431 SER B OG 1 ATOM 7650 N N . ILE B 1 432 ? 23.414 4.013 -7.573 1.00 37.22 ? 432 ILE B N 1 ATOM 7651 C CA . ILE B 1 432 ? 24.462 3.382 -6.763 1.00 37.89 ? 432 ILE B CA 1 ATOM 7652 C C . ILE B 1 432 ? 24.219 1.855 -6.751 1.00 45.61 ? 432 ILE B C 1 ATOM 7653 O O . ILE B 1 432 ? 25.136 1.105 -7.065 1.00 46.00 ? 432 ILE B O 1 ATOM 7654 C CB . ILE B 1 432 ? 24.507 4.005 -5.319 1.00 40.45 ? 432 ILE B CB 1 ATOM 7655 C CG1 . ILE B 1 432 ? 25.236 5.368 -5.314 1.00 39.83 ? 432 ILE B CG1 1 ATOM 7656 C CG2 . ILE B 1 432 ? 25.091 3.027 -4.266 1.00 40.23 ? 432 ILE B CG2 1 ATOM 7657 C CD1 . ILE B 1 432 ? 25.166 6.196 -3.984 1.00 40.02 ? 432 ILE B CD1 1 ATOM 7658 N N . LEU B 1 433 ? 22.980 1.410 -6.413 1.00 44.44 ? 433 LEU B N 1 ATOM 7659 C CA . LEU B 1 433 ? 22.586 -0.009 -6.374 1.00 45.09 ? 433 LEU B CA 1 ATOM 7660 C C . LEU B 1 433 ? 22.730 -0.689 -7.734 1.00 50.36 ? 433 LEU B C 1 ATOM 7661 O O . LEU B 1 433 ? 23.016 -1.882 -7.773 1.00 50.83 ? 433 LEU B O 1 ATOM 7662 C CB . LEU B 1 433 ? 21.140 -0.203 -5.879 1.00 45.11 ? 433 LEU B CB 1 ATOM 7663 C CG . LEU B 1 433 ? 20.755 0.290 -4.498 1.00 49.68 ? 433 LEU B CG 1 ATOM 7664 C CD1 . LEU B 1 433 ? 19.306 -0.018 -4.230 1.00 49.62 ? 433 LEU B CD1 1 ATOM 7665 C CD2 . LEU B 1 433 ? 21.651 -0.299 -3.411 1.00 53.54 ? 433 LEU B CD2 1 ATOM 7666 N N . LEU B 1 434 ? 22.490 0.048 -8.838 1.00 46.66 ? 434 LEU B N 1 ATOM 7667 C CA . LEU B 1 434 ? 22.647 -0.491 -10.191 1.00 46.60 ? 434 LEU B CA 1 ATOM 7668 C C . LEU B 1 434 ? 24.141 -0.730 -10.471 1.00 53.55 ? 434 LEU B C 1 ATOM 7669 O O . LEU B 1 434 ? 24.517 -1.840 -10.872 1.00 53.63 ? 434 LEU B O 1 ATOM 7670 C CB . LEU B 1 434 ? 22.053 0.467 -11.249 1.00 45.90 ? 434 LEU B CB 1 ATOM 7671 C CG . LEU B 1 434 ? 20.544 0.466 -11.458 1.00 48.93 ? 434 LEU B CG 1 ATOM 7672 C CD1 . LEU B 1 434 ? 20.112 1.730 -12.162 1.00 48.90 ? 434 LEU B CD1 1 ATOM 7673 C CD2 . LEU B 1 434 ? 20.083 -0.753 -12.242 1.00 48.73 ? 434 LEU B CD2 1 ATOM 7674 N N . ALA B 1 435 ? 24.980 0.318 -10.223 1.00 51.54 ? 435 ALA B N 1 ATOM 7675 C CA . ALA B 1 435 ? 26.436 0.370 -10.418 1.00 52.12 ? 435 ALA B CA 1 ATOM 7676 C C . ALA B 1 435 ? 27.189 -0.718 -9.672 1.00 58.62 ? 435 ALA B C 1 ATOM 7677 O O . ALA B 1 435 ? 28.184 -1.229 -10.187 1.00 59.29 ? 435 ALA B O 1 ATOM 7678 C CB . ALA B 1 435 ? 26.970 1.736 -10.000 1.00 52.82 ? 435 ALA B CB 1 ATOM 7679 N N . GLN B 1 436 ? 26.729 -1.050 -8.455 1.00 56.53 ? 436 GLN B N 1 ATOM 7680 C CA . GLN B 1 436 ? 27.323 -2.055 -7.571 1.00 56.92 ? 436 GLN B CA 1 ATOM 7681 C C . GLN B 1 436 ? 26.643 -3.416 -7.714 1.00 63.90 ? 436 GLN B C 1 ATOM 7682 O O . GLN B 1 436 ? 27.175 -4.414 -7.224 1.00 64.10 ? 436 GLN B O 1 ATOM 7683 C CB . GLN B 1 436 ? 27.243 -1.587 -6.100 1.00 57.70 ? 436 GLN B CB 1 ATOM 7684 C CG . GLN B 1 436 ? 27.952 -0.264 -5.795 1.00 54.94 ? 436 GLN B CG 1 ATOM 7685 C CD . GLN B 1 436 ? 29.416 -0.324 -6.122 1.00 69.23 ? 436 GLN B CD 1 ATOM 7686 O OE1 . GLN B 1 436 ? 30.195 -1.008 -5.459 1.00 71.65 ? 436 GLN B OE1 1 ATOM 7687 N NE2 . GLN B 1 436 ? 29.813 0.357 -7.175 1.00 55.87 ? 436 GLN B NE2 1 ATOM 7688 N N . GLU B 1 437 ? 25.468 -3.451 -8.381 1.00 62.41 ? 437 GLU B N 1 ATOM 7689 C CA . GLU B 1 437 ? 24.613 -4.628 -8.578 1.00 63.29 ? 437 GLU B CA 1 ATOM 7690 C C . GLU B 1 437 ? 24.189 -5.233 -7.218 1.00 69.22 ? 437 GLU B C 1 ATOM 7691 O O . GLU B 1 437 ? 24.039 -6.449 -7.080 1.00 69.22 ? 437 GLU B O 1 ATOM 7692 C CB . GLU B 1 437 ? 25.239 -5.644 -9.552 1.00 64.93 ? 437 GLU B CB 1 ATOM 7693 C CG . GLU B 1 437 ? 25.219 -5.147 -10.991 1.00 77.69 ? 437 GLU B CG 1 ATOM 7694 C CD . GLU B 1 437 ? 26.143 -5.829 -11.978 1.00 98.68 ? 437 GLU B CD 1 ATOM 7695 O OE1 . GLU B 1 437 ? 26.114 -7.079 -12.056 1.00 82.43 ? 437 GLU B OE1 1 ATOM 7696 O OE2 . GLU B 1 437 ? 26.845 -5.107 -12.724 1.00 95.96 ? 437 GLU B OE2 1 ATOM 7697 N N . GLN B 1 438 ? 23.987 -4.341 -6.220 1.00 66.51 ? 438 GLN B N 1 ATOM 7698 C CA . GLN B 1 438 ? 23.584 -4.639 -4.846 1.00 66.43 ? 438 GLN B CA 1 ATOM 7699 C C . GLN B 1 438 ? 22.058 -4.449 -4.694 1.00 70.28 ? 438 GLN B C 1 ATOM 7700 O O . GLN B 1 438 ? 21.559 -4.286 -3.571 1.00 70.41 ? 438 GLN B O 1 ATOM 7701 C CB . GLN B 1 438 ? 24.353 -3.734 -3.855 1.00 67.81 ? 438 GLN B CB 1 ATOM 7702 C CG . GLN B 1 438 ? 25.811 -4.125 -3.599 1.00 81.29 ? 438 GLN B CG 1 ATOM 7703 C CD . GLN B 1 438 ? 26.396 -3.379 -2.407 1.00 101.72 ? 438 GLN B CD 1 ATOM 7704 O OE1 . GLN B 1 438 ? 26.396 -2.142 -2.344 1.00 99.19 ? 438 GLN B OE1 1 ATOM 7705 N NE2 . GLN B 1 438 ? 26.919 -4.109 -1.430 1.00 88.99 ? 438 GLN B NE2 1 ATOM 7706 N N . LEU B 1 439 ? 21.320 -4.487 -5.828 1.00 66.01 ? 439 LEU B N 1 ATOM 7707 C CA . LEU B 1 439 ? 19.858 -4.338 -5.871 1.00 65.63 ? 439 LEU B CA 1 ATOM 7708 C C . LEU B 1 439 ? 19.127 -5.486 -5.166 1.00 70.21 ? 439 LEU B C 1 ATOM 7709 O O . LEU B 1 439 ? 18.179 -5.255 -4.407 1.00 70.06 ? 439 LEU B O 1 ATOM 7710 C CB . LEU B 1 439 ? 19.380 -4.272 -7.321 1.00 65.39 ? 439 LEU B CB 1 ATOM 7711 C CG . LEU B 1 439 ? 19.480 -2.934 -8.001 1.00 69.55 ? 439 LEU B CG 1 ATOM 7712 C CD1 . LEU B 1 439 ? 19.925 -3.112 -9.405 1.00 69.67 ? 439 LEU B CD1 1 ATOM 7713 C CD2 . LEU B 1 439 ? 18.148 -2.220 -7.988 1.00 71.27 ? 439 LEU B CD2 1 ATOM 7714 N N . GLU B 1 440 ? 19.568 -6.726 -5.435 1.00 66.32 ? 440 GLU B N 1 ATOM 7715 C CA . GLU B 1 440 ? 18.964 -7.935 -4.873 1.00 65.18 ? 440 GLU B CA 1 ATOM 7716 C C . GLU B 1 440 ? 19.369 -8.146 -3.407 1.00 65.21 ? 440 GLU B C 1 ATOM 7717 O O . GLU B 1 440 ? 18.690 -8.889 -2.697 1.00 64.05 ? 440 GLU B O 1 ATOM 7718 C CB . GLU B 1 440 ? 19.283 -9.174 -5.737 1.00 66.73 ? 440 GLU B CB 1 ATOM 7719 C CG . GLU B 1 440 ? 18.880 -9.051 -7.202 1.00 75.99 ? 440 GLU B CG 1 ATOM 7720 C CD . GLU B 1 440 ? 17.993 -10.162 -7.730 1.00 96.34 ? 440 GLU B CD 1 ATOM 7721 O OE1 . GLU B 1 440 ? 16.819 -9.881 -8.073 1.00 100.25 ? 440 GLU B OE1 1 ATOM 7722 O OE2 . GLU B 1 440 ? 18.481 -11.311 -7.831 1.00 80.90 ? 440 GLU B OE2 1 ATOM 7723 N N . LYS B 1 441 ? 20.457 -7.481 -2.957 1.00 59.76 ? 441 LYS B N 1 ATOM 7724 C CA . LYS B 1 441 ? 20.970 -7.545 -1.582 1.00 58.90 ? 441 LYS B CA 1 ATOM 7725 C C . LYS B 1 441 ? 20.028 -6.789 -0.632 1.00 62.51 ? 441 LYS B C 1 ATOM 7726 O O . LYS B 1 441 ? 19.808 -5.594 -0.814 1.00 62.22 ? 441 LYS B O 1 ATOM 7727 C CB . LYS B 1 441 ? 22.399 -6.955 -1.512 1.00 60.79 ? 441 LYS B CB 1 ATOM 7728 C CG . LYS B 1 441 ? 23.065 -7.015 -0.131 1.00 68.77 ? 441 LYS B CG 1 ATOM 7729 C CD . LYS B 1 441 ? 24.306 -6.112 -0.053 1.00 74.93 ? 441 LYS B CD 1 ATOM 7730 C CE . LYS B 1 441 ? 24.877 -6.005 1.348 1.00 77.03 ? 441 LYS B CE 1 ATOM 7731 N NZ . LYS B 1 441 ? 25.913 -4.934 1.454 1.00 78.69 ? 441 LYS B NZ 1 ATOM 7732 N N . ALA B 1 442 ? 19.490 -7.486 0.386 1.00 58.95 ? 442 ALA B N 1 ATOM 7733 C CA . ALA B 1 442 ? 18.587 -6.902 1.383 1.00 58.22 ? 442 ALA B CA 1 ATOM 7734 C C . ALA B 1 442 ? 19.358 -5.980 2.291 1.00 60.83 ? 442 ALA B C 1 ATOM 7735 O O . ALA B 1 442 ? 20.502 -6.278 2.645 1.00 60.69 ? 442 ALA B O 1 ATOM 7736 C CB . ALA B 1 442 ? 17.919 -7.996 2.201 1.00 58.95 ? 442 ALA B CB 1 ATOM 7737 N N . LEU B 1 443 ? 18.741 -4.849 2.652 1.00 56.51 ? 443 LEU B N 1 ATOM 7738 C CA . LEU B 1 443 ? 19.375 -3.846 3.503 1.00 55.81 ? 443 LEU B CA 1 ATOM 7739 C C . LEU B 1 443 ? 18.637 -3.613 4.808 1.00 60.14 ? 443 LEU B C 1 ATOM 7740 O O . LEU B 1 443 ? 17.405 -3.642 4.839 1.00 59.76 ? 443 LEU B O 1 ATOM 7741 C CB . LEU B 1 443 ? 19.592 -2.530 2.734 1.00 55.35 ? 443 LEU B CB 1 ATOM 7742 C CG . LEU B 1 443 ? 20.646 -2.578 1.623 1.00 58.65 ? 443 LEU B CG 1 ATOM 7743 C CD1 . LEU B 1 443 ? 20.423 -1.492 0.627 1.00 58.46 ? 443 LEU B CD1 1 ATOM 7744 C CD2 . LEU B 1 443 ? 22.056 -2.511 2.185 1.00 59.30 ? 443 LEU B CD2 1 ATOM 7745 N N . ASP B 1 444 ? 19.401 -3.393 5.886 1.00 57.16 ? 444 ASP B N 1 ATOM 7746 C CA . ASP B 1 444 ? 18.865 -3.146 7.221 1.00 57.61 ? 444 ASP B CA 1 ATOM 7747 C C . ASP B 1 444 ? 18.574 -1.662 7.430 1.00 62.00 ? 444 ASP B C 1 ATOM 7748 O O . ASP B 1 444 ? 19.497 -0.843 7.382 1.00 61.91 ? 444 ASP B O 1 ATOM 7749 C CB . ASP B 1 444 ? 19.850 -3.648 8.302 1.00 60.05 ? 444 ASP B CB 1 ATOM 7750 C CG . ASP B 1 444 ? 19.742 -5.109 8.717 1.00 74.04 ? 444 ASP B CG 1 ATOM 7751 O OD1 . ASP B 1 444 ? 18.930 -5.845 8.112 1.00 77.01 ? 444 ASP B OD1 1 ATOM 7752 O OD2 . ASP B 1 444 ? 20.460 -5.513 9.658 1.00 77.98 ? 444 ASP B OD2 1 ATOM 7753 N N . CYS B 1 445 ? 17.300 -1.308 7.655 1.00 58.83 ? 445 CYS B N 1 ATOM 7754 C CA . CYS B 1 445 ? 16.923 0.075 7.942 1.00 59.10 ? 445 CYS B CA 1 ATOM 7755 C C . CYS B 1 445 ? 16.059 0.171 9.206 1.00 63.45 ? 445 CYS B C 1 ATOM 7756 O O . CYS B 1 445 ? 15.850 -0.844 9.872 1.00 63.35 ? 445 CYS B O 1 ATOM 7757 C CB . CYS B 1 445 ? 16.277 0.748 6.734 1.00 59.87 ? 445 CYS B CB 1 ATOM 7758 S SG . CYS B 1 445 ? 14.616 0.155 6.338 1.00 64.04 ? 445 CYS B SG 1 ATOM 7759 N N . GLN B 1 446 ? 15.605 1.381 9.568 1.00 60.39 ? 446 GLN B N 1 ATOM 7760 C CA . GLN B 1 446 ? 14.784 1.599 10.757 1.00 60.67 ? 446 GLN B CA 1 ATOM 7761 C C . GLN B 1 446 ? 13.518 2.377 10.477 1.00 63.28 ? 446 GLN B C 1 ATOM 7762 O O . GLN B 1 446 ? 13.560 3.428 9.844 1.00 62.57 ? 446 GLN B O 1 ATOM 7763 C CB . GLN B 1 446 ? 15.583 2.271 11.879 1.00 62.83 ? 446 GLN B CB 1 ATOM 7764 C CG . GLN B 1 446 ? 16.336 1.285 12.763 1.00 89.09 ? 446 GLN B CG 1 ATOM 7765 C CD . GLN B 1 446 ? 16.633 1.860 14.126 1.00 115.74 ? 446 GLN B CD 1 ATOM 7766 O OE1 . GLN B 1 446 ? 15.762 2.440 14.791 1.00 114.50 ? 446 GLN B OE1 1 ATOM 7767 N NE2 . GLN B 1 446 ? 17.863 1.675 14.592 1.00 106.52 ? 446 GLN B NE2 1 ATOM 7768 N N . ILE B 1 447 ? 12.392 1.862 10.966 1.00 59.70 ? 447 ILE B N 1 ATOM 7769 C CA . ILE B 1 447 ? 11.068 2.464 10.811 1.00 59.47 ? 447 ILE B CA 1 ATOM 7770 C C . ILE B 1 447 ? 10.398 2.464 12.184 1.00 63.41 ? 447 ILE B C 1 ATOM 7771 O O . ILE B 1 447 ? 10.329 1.406 12.819 1.00 63.34 ? 447 ILE B O 1 ATOM 7772 C CB . ILE B 1 447 ? 10.241 1.733 9.711 1.00 62.34 ? 447 ILE B CB 1 ATOM 7773 C CG1 . ILE B 1 447 ? 10.751 2.112 8.309 1.00 62.72 ? 447 ILE B CG1 1 ATOM 7774 C CG2 . ILE B 1 447 ? 8.727 1.998 9.836 1.00 63.06 ? 447 ILE B CG2 1 ATOM 7775 C CD1 . ILE B 1 447 ? 11.210 0.954 7.510 1.00 71.22 ? 447 ILE B CD1 1 ATOM 7776 N N . TYR B 1 448 ? 9.934 3.660 12.650 1.00 58.84 ? 448 TYR B N 1 ATOM 7777 C CA . TYR B 1 448 ? 9.295 3.894 13.963 1.00 57.55 ? 448 TYR B CA 1 ATOM 7778 C C . TYR B 1 448 ? 10.192 3.407 15.142 1.00 59.15 ? 448 TYR B C 1 ATOM 7779 O O . TYR B 1 448 ? 9.685 3.089 16.218 1.00 58.38 ? 448 TYR B O 1 ATOM 7780 C CB . TYR B 1 448 ? 7.870 3.277 14.028 1.00 58.02 ? 448 TYR B CB 1 ATOM 7781 C CG . TYR B 1 448 ? 6.760 4.034 13.317 1.00 58.63 ? 448 TYR B CG 1 ATOM 7782 C CD1 . TYR B 1 448 ? 7.023 5.208 12.614 1.00 60.29 ? 448 TYR B CD1 1 ATOM 7783 C CD2 . TYR B 1 448 ? 5.441 3.576 13.352 1.00 58.75 ? 448 TYR B CD2 1 ATOM 7784 C CE1 . TYR B 1 448 ? 6.006 5.903 11.958 1.00 60.41 ? 448 TYR B CE1 1 ATOM 7785 C CE2 . TYR B 1 448 ? 4.416 4.266 12.701 1.00 58.97 ? 448 TYR B CE2 1 ATOM 7786 C CZ . TYR B 1 448 ? 4.705 5.426 12.001 1.00 64.01 ? 448 TYR B CZ 1 ATOM 7787 O OH . TYR B 1 448 ? 3.706 6.125 11.369 1.00 62.04 ? 448 TYR B OH 1 ATOM 7788 N N . GLY B 1 449 ? 11.510 3.365 14.903 1.00 53.92 ? 449 GLY B N 1 ATOM 7789 C CA . GLY B 1 449 ? 12.507 2.904 15.858 1.00 52.92 ? 449 GLY B CA 1 ATOM 7790 C C . GLY B 1 449 ? 12.769 1.409 15.809 1.00 55.18 ? 449 GLY B C 1 ATOM 7791 O O . GLY B 1 449 ? 13.663 0.925 16.509 1.00 53.74 ? 449 GLY B O 1 ATOM 7792 N N . ALA B 1 450 ? 11.979 0.663 14.989 1.00 51.65 ? 450 ALA B N 1 ATOM 7793 C CA . ALA B 1 450 ? 12.078 -0.795 14.789 1.00 50.68 ? 450 ALA B CA 1 ATOM 7794 C C . ALA B 1 450 ? 12.987 -1.128 13.601 1.00 54.35 ? 450 ALA B C 1 ATOM 7795 O O . ALA B 1 450 ? 12.904 -0.455 12.564 1.00 54.70 ? 450 ALA B O 1 ATOM 7796 C CB . ALA B 1 450 ? 10.694 -1.388 14.563 1.00 51.03 ? 450 ALA B CB 1 ATOM 7797 N N A CYS B 1 451 ? 13.843 -2.156 13.748 0.50 50.28 ? 451 CYS B N 1 ATOM 7798 N N B CYS B 1 451 ? 13.858 -2.146 13.751 0.50 49.88 ? 451 CYS B N 1 ATOM 7799 C CA A CYS B 1 451 ? 14.769 -2.585 12.699 0.50 49.92 ? 451 CYS B CA 1 ATOM 7800 C CA B CYS B 1 451 ? 14.767 -2.557 12.678 0.50 49.34 ? 451 CYS B CA 1 ATOM 7801 C C A CYS B 1 451 ? 14.111 -3.496 11.657 0.50 53.02 ? 451 CYS B C 1 ATOM 7802 C C B CYS B 1 451 ? 14.076 -3.458 11.653 0.50 52.82 ? 451 CYS B C 1 ATOM 7803 O O A CYS B 1 451 ? 13.409 -4.444 12.015 0.50 52.99 ? 451 CYS B O 1 ATOM 7804 O O B CYS B 1 451 ? 13.335 -4.372 12.021 0.50 52.86 ? 451 CYS B O 1 ATOM 7805 C CB A CYS B 1 451 ? 16.023 -3.217 13.294 0.50 50.29 ? 451 CYS B CB 1 ATOM 7806 C CB B CYS B 1 451 ? 16.039 -3.197 13.224 0.50 49.47 ? 451 CYS B CB 1 ATOM 7807 S SG A CYS B 1 451 ? 17.546 -2.298 12.950 0.50 54.28 ? 451 CYS B SG 1 ATOM 7808 S SG B CYS B 1 451 ? 17.259 -3.623 11.950 0.50 53.31 ? 451 CYS B SG 1 ATOM 7809 N N . TYR B 1 452 ? 14.339 -3.199 10.367 1.00 48.51 ? 452 TYR B N 1 ATOM 7810 C CA . TYR B 1 452 ? 13.772 -3.949 9.248 1.00 47.64 ? 452 TYR B CA 1 ATOM 7811 C C . TYR B 1 452 ? 14.819 -4.326 8.243 1.00 52.66 ? 452 TYR B C 1 ATOM 7812 O O . TYR B 1 452 ? 15.726 -3.539 7.977 1.00 53.39 ? 452 TYR B O 1 ATOM 7813 C CB . TYR B 1 452 ? 12.700 -3.100 8.530 1.00 47.74 ? 452 TYR B CB 1 ATOM 7814 C CG . TYR B 1 452 ? 11.335 -3.192 9.167 1.00 47.94 ? 452 TYR B CG 1 ATOM 7815 C CD1 . TYR B 1 452 ? 10.959 -2.319 10.183 1.00 49.87 ? 452 TYR B CD1 1 ATOM 7816 C CD2 . TYR B 1 452 ? 10.430 -4.178 8.781 1.00 47.49 ? 452 TYR B CD2 1 ATOM 7817 C CE1 . TYR B 1 452 ? 9.711 -2.416 10.791 1.00 50.46 ? 452 TYR B CE1 1 ATOM 7818 C CE2 . TYR B 1 452 ? 9.174 -4.276 9.372 1.00 47.70 ? 452 TYR B CE2 1 ATOM 7819 C CZ . TYR B 1 452 ? 8.822 -3.399 10.384 1.00 56.07 ? 452 TYR B CZ 1 ATOM 7820 O OH . TYR B 1 452 ? 7.596 -3.515 10.989 1.00 57.31 ? 452 TYR B OH 1 ATOM 7821 N N . SER B 1 453 ? 14.674 -5.508 7.645 1.00 48.82 ? 453 SER B N 1 ATOM 7822 C CA . SER B 1 453 ? 15.528 -5.913 6.542 1.00 48.50 ? 453 SER B CA 1 ATOM 7823 C C . SER B 1 453 ? 14.620 -5.817 5.303 1.00 52.82 ? 453 SER B C 1 ATOM 7824 O O . SER B 1 453 ? 13.594 -6.505 5.227 1.00 52.55 ? 453 SER B O 1 ATOM 7825 C CB . SER B 1 453 ? 16.078 -7.320 6.739 1.00 50.96 ? 453 SER B CB 1 ATOM 7826 O OG . SER B 1 453 ? 17.238 -7.521 5.948 1.00 58.20 ? 453 SER B OG 1 ATOM 7827 N N . ILE B 1 454 ? 14.938 -4.884 4.392 1.00 49.18 ? 454 ILE B N 1 ATOM 7828 C CA . ILE B 1 454 ? 14.141 -4.650 3.192 1.00 48.90 ? 454 ILE B CA 1 ATOM 7829 C C . ILE B 1 454 ? 14.932 -4.937 1.930 1.00 55.76 ? 454 ILE B C 1 ATOM 7830 O O . ILE B 1 454 ? 16.093 -4.534 1.812 1.00 55.07 ? 454 ILE B O 1 ATOM 7831 C CB . ILE B 1 454 ? 13.512 -3.224 3.218 1.00 50.96 ? 454 ILE B CB 1 ATOM 7832 C CG1 . ILE B 1 454 ? 12.195 -3.254 4.002 1.00 50.57 ? 454 ILE B CG1 1 ATOM 7833 C CG2 . ILE B 1 454 ? 13.292 -2.630 1.814 1.00 50.83 ? 454 ILE B CG2 1 ATOM 7834 C CD1 . ILE B 1 454 ? 12.044 -2.202 4.980 1.00 53.63 ? 454 ILE B CD1 1 ATOM 7835 N N . GLU B 1 455 ? 14.295 -5.649 0.991 1.00 54.60 ? 455 GLU B N 1 ATOM 7836 C CA . GLU B 1 455 ? 14.875 -5.918 -0.316 1.00 55.47 ? 455 GLU B CA 1 ATOM 7837 C C . GLU B 1 455 ? 14.547 -4.672 -1.165 1.00 59.63 ? 455 GLU B C 1 ATOM 7838 O O . GLU B 1 455 ? 13.360 -4.392 -1.379 1.00 58.77 ? 455 GLU B O 1 ATOM 7839 C CB . GLU B 1 455 ? 14.267 -7.185 -0.936 1.00 57.16 ? 455 GLU B CB 1 ATOM 7840 C CG . GLU B 1 455 ? 14.777 -8.493 -0.351 1.00 67.30 ? 455 GLU B CG 1 ATOM 7841 C CD . GLU B 1 455 ? 15.472 -9.406 -1.344 1.00 88.56 ? 455 GLU B CD 1 ATOM 7842 O OE1 . GLU B 1 455 ? 14.974 -9.551 -2.486 1.00 82.39 ? 455 GLU B OE1 1 ATOM 7843 O OE2 . GLU B 1 455 ? 16.513 -9.995 -0.969 1.00 81.64 ? 455 GLU B OE2 1 ATOM 7844 N N . PRO B 1 456 ? 15.567 -3.881 -1.601 1.00 57.13 ? 456 PRO B N 1 ATOM 7845 C CA . PRO B 1 456 ? 15.286 -2.640 -2.361 1.00 57.07 ? 456 PRO B CA 1 ATOM 7846 C C . PRO B 1 456 ? 14.396 -2.777 -3.597 1.00 60.55 ? 456 PRO B C 1 ATOM 7847 O O . PRO B 1 456 ? 13.760 -1.798 -3.995 1.00 60.50 ? 456 PRO B O 1 ATOM 7848 C CB . PRO B 1 456 ? 16.682 -2.127 -2.738 1.00 58.71 ? 456 PRO B CB 1 ATOM 7849 C CG . PRO B 1 456 ? 17.582 -2.687 -1.698 1.00 63.02 ? 456 PRO B CG 1 ATOM 7850 C CD . PRO B 1 456 ? 17.019 -4.050 -1.386 1.00 58.76 ? 456 PRO B CD 1 ATOM 7851 N N . LEU B 1 457 ? 14.336 -3.979 -4.188 1.00 56.06 ? 457 LEU B N 1 ATOM 7852 C CA . LEU B 1 457 ? 13.517 -4.244 -5.366 1.00 55.10 ? 457 LEU B CA 1 ATOM 7853 C C . LEU B 1 457 ? 12.029 -4.358 -5.040 1.00 58.22 ? 457 LEU B C 1 ATOM 7854 O O . LEU B 1 457 ? 11.194 -4.185 -5.932 1.00 58.09 ? 457 LEU B O 1 ATOM 7855 C CB . LEU B 1 457 ? 14.040 -5.469 -6.130 1.00 55.06 ? 457 LEU B CB 1 ATOM 7856 C CG . LEU B 1 457 ? 15.348 -5.238 -6.893 1.00 60.08 ? 457 LEU B CG 1 ATOM 7857 C CD1 . LEU B 1 457 ? 16.091 -6.527 -7.122 1.00 60.36 ? 457 LEU B CD1 1 ATOM 7858 C CD2 . LEU B 1 457 ? 15.100 -4.527 -8.203 1.00 63.24 ? 457 LEU B CD2 1 ATOM 7859 N N . ASP B 1 458 ? 11.701 -4.609 -3.755 1.00 54.39 ? 458 ASP B N 1 ATOM 7860 C CA . ASP B 1 458 ? 10.329 -4.712 -3.240 1.00 53.91 ? 458 ASP B CA 1 ATOM 7861 C C . ASP B 1 458 ? 9.725 -3.343 -2.879 1.00 55.29 ? 458 ASP B C 1 ATOM 7862 O O . ASP B 1 458 ? 8.570 -3.278 -2.453 1.00 54.76 ? 458 ASP B O 1 ATOM 7863 C CB . ASP B 1 458 ? 10.269 -5.660 -2.026 1.00 55.92 ? 458 ASP B CB 1 ATOM 7864 C CG . ASP B 1 458 ? 10.475 -7.120 -2.365 1.00 69.05 ? 458 ASP B CG 1 ATOM 7865 O OD1 . ASP B 1 458 ? 9.845 -7.604 -3.338 1.00 70.05 ? 458 ASP B OD1 1 ATOM 7866 O OD2 . ASP B 1 458 ? 11.215 -7.794 -1.628 1.00 75.89 ? 458 ASP B OD2 1 ATOM 7867 N N . LEU B 1 459 ? 10.494 -2.256 -3.075 1.00 49.38 ? 459 LEU B N 1 ATOM 7868 C CA . LEU B 1 459 ? 10.060 -0.899 -2.780 1.00 48.41 ? 459 LEU B CA 1 ATOM 7869 C C . LEU B 1 459 ? 8.718 -0.507 -3.422 1.00 51.17 ? 459 LEU B C 1 ATOM 7870 O O . LEU B 1 459 ? 7.909 0.026 -2.675 1.00 51.30 ? 459 LEU B O 1 ATOM 7871 C CB . LEU B 1 459 ? 11.147 0.133 -3.099 1.00 48.51 ? 459 LEU B CB 1 ATOM 7872 C CG . LEU B 1 459 ? 12.132 0.371 -1.955 1.00 52.90 ? 459 LEU B CG 1 ATOM 7873 C CD1 . LEU B 1 459 ? 13.345 1.158 -2.408 1.00 52.73 ? 459 LEU B CD1 1 ATOM 7874 C CD2 . LEU B 1 459 ? 11.460 1.054 -0.791 1.00 54.17 ? 459 LEU B CD2 1 ATOM 7875 N N . PRO B 1 460 ? 8.385 -0.789 -4.716 1.00 46.84 ? 460 PRO B N 1 ATOM 7876 C CA . PRO B 1 460 ? 7.056 -0.395 -5.222 1.00 46.10 ? 460 PRO B CA 1 ATOM 7877 C C . PRO B 1 460 ? 5.899 -1.084 -4.496 1.00 48.94 ? 460 PRO B C 1 ATOM 7878 O O . PRO B 1 460 ? 4.848 -0.471 -4.317 1.00 47.46 ? 460 PRO B O 1 ATOM 7879 C CB . PRO B 1 460 ? 7.112 -0.762 -6.711 1.00 47.73 ? 460 PRO B CB 1 ATOM 7880 C CG . PRO B 1 460 ? 8.548 -0.889 -7.033 1.00 52.27 ? 460 PRO B CG 1 ATOM 7881 C CD . PRO B 1 460 ? 9.175 -1.425 -5.791 1.00 48.13 ? 460 PRO B CD 1 ATOM 7882 N N . GLN B 1 461 ? 6.107 -2.343 -4.049 1.00 46.55 ? 461 GLN B N 1 ATOM 7883 C CA . GLN B 1 461 ? 5.117 -3.132 -3.293 1.00 46.75 ? 461 GLN B CA 1 ATOM 7884 C C . GLN B 1 461 ? 4.894 -2.470 -1.926 1.00 49.49 ? 461 GLN B C 1 ATOM 7885 O O . GLN B 1 461 ? 3.748 -2.132 -1.602 1.00 49.67 ? 461 GLN B O 1 ATOM 7886 C CB . GLN B 1 461 ? 5.569 -4.606 -3.123 1.00 48.53 ? 461 GLN B CB 1 ATOM 7887 C CG . GLN B 1 461 ? 5.630 -5.423 -4.426 1.00 72.64 ? 461 GLN B CG 1 ATOM 7888 C CD . GLN B 1 461 ? 6.988 -5.408 -5.103 1.00 94.23 ? 461 GLN B CD 1 ATOM 7889 O OE1 . GLN B 1 461 ? 7.323 -4.499 -5.876 1.00 89.88 ? 461 GLN B OE1 1 ATOM 7890 N NE2 . GLN B 1 461 ? 7.775 -6.455 -4.880 1.00 84.88 ? 461 GLN B NE2 1 ATOM 7891 N N . ILE B 1 462 ? 6.009 -2.218 -1.171 1.00 43.22 ? 462 ILE B N 1 ATOM 7892 C CA . ILE B 1 462 ? 6.039 -1.571 0.150 1.00 41.26 ? 462 ILE B CA 1 ATOM 7893 C C . ILE B 1 462 ? 5.410 -0.174 0.114 1.00 45.14 ? 462 ILE B C 1 ATOM 7894 O O . ILE B 1 462 ? 4.626 0.158 1.008 1.00 46.00 ? 462 ILE B O 1 ATOM 7895 C CB . ILE B 1 462 ? 7.466 -1.549 0.784 1.00 43.25 ? 462 ILE B CB 1 ATOM 7896 C CG1 . ILE B 1 462 ? 8.109 -2.950 0.796 1.00 42.50 ? 462 ILE B CG1 1 ATOM 7897 C CG2 . ILE B 1 462 ? 7.434 -0.956 2.206 1.00 43.93 ? 462 ILE B CG2 1 ATOM 7898 C CD1 . ILE B 1 462 ? 9.595 -2.972 1.035 1.00 46.32 ? 462 ILE B CD1 1 ATOM 7899 N N . ILE B 1 463 ? 5.745 0.633 -0.910 1.00 40.64 ? 463 ILE B N 1 ATOM 7900 C CA . ILE B 1 463 ? 5.240 2.004 -1.040 1.00 40.47 ? 463 ILE B CA 1 ATOM 7901 C C . ILE B 1 463 ? 3.735 2.006 -1.259 1.00 46.14 ? 463 ILE B C 1 ATOM 7902 O O . ILE B 1 463 ? 3.032 2.770 -0.582 1.00 46.56 ? 463 ILE B O 1 ATOM 7903 C CB . ILE B 1 463 ? 6.025 2.859 -2.082 1.00 42.67 ? 463 ILE B CB 1 ATOM 7904 C CG1 . ILE B 1 463 ? 7.433 3.170 -1.532 1.00 42.33 ? 463 ILE B CG1 1 ATOM 7905 C CG2 . ILE B 1 463 ? 5.279 4.158 -2.415 1.00 42.73 ? 463 ILE B CG2 1 ATOM 7906 C CD1 . ILE B 1 463 ? 8.481 3.416 -2.522 1.00 47.21 ? 463 ILE B CD1 1 ATOM 7907 N N . GLU B 1 464 ? 3.238 1.127 -2.152 1.00 42.98 ? 464 GLU B N 1 ATOM 7908 C CA . GLU B 1 464 ? 1.811 1.000 -2.437 1.00 42.52 ? 464 GLU B CA 1 ATOM 7909 C C . GLU B 1 464 ? 1.090 0.684 -1.137 1.00 47.35 ? 464 GLU B C 1 ATOM 7910 O O . GLU B 1 464 ? 0.108 1.345 -0.829 1.00 47.64 ? 464 GLU B O 1 ATOM 7911 C CB . GLU B 1 464 ? 1.566 -0.094 -3.485 1.00 43.89 ? 464 GLU B CB 1 ATOM 7912 C CG . GLU B 1 464 ? 0.099 -0.302 -3.839 1.00 54.83 ? 464 GLU B CG 1 ATOM 7913 C CD . GLU B 1 464 ? -0.225 -1.240 -4.987 1.00 74.39 ? 464 GLU B CD 1 ATOM 7914 O OE1 . GLU B 1 464 ? 0.634 -2.061 -5.380 1.00 59.82 ? 464 GLU B OE1 1 ATOM 7915 O OE2 . GLU B 1 464 ? -1.374 -1.170 -5.472 1.00 74.09 ? 464 GLU B OE2 1 ATOM 7916 N N . ARG B 1 465 ? 1.630 -0.251 -0.334 1.00 44.39 ? 465 ARG B N 1 ATOM 7917 C CA . ARG B 1 465 ? 1.036 -0.663 0.942 1.00 44.96 ? 465 ARG B CA 1 ATOM 7918 C C . ARG B 1 465 ? 1.052 0.420 2.065 1.00 49.98 ? 465 ARG B C 1 ATOM 7919 O O . ARG B 1 465 ? 0.364 0.221 3.070 1.00 50.98 ? 465 ARG B O 1 ATOM 7920 C CB . ARG B 1 465 ? 1.665 -1.977 1.448 1.00 46.67 ? 465 ARG B CB 1 ATOM 7921 C CG . ARG B 1 465 ? 1.446 -3.180 0.533 1.00 65.47 ? 465 ARG B CG 1 ATOM 7922 C CD . ARG B 1 465 ? 1.137 -4.399 1.378 1.00 82.07 ? 465 ARG B CD 1 ATOM 7923 N NE . ARG B 1 465 ? -0.121 -5.045 0.989 1.00 92.37 ? 465 ARG B NE 1 ATOM 7924 C CZ . ARG B 1 465 ? -0.468 -6.289 1.315 1.00 105.39 ? 465 ARG B CZ 1 ATOM 7925 N NH1 . ARG B 1 465 ? 0.353 -7.052 2.028 1.00 89.48 ? 465 ARG B NH1 1 ATOM 7926 N NH2 . ARG B 1 465 ? -1.633 -6.784 0.917 1.00 95.15 ? 465 ARG B NH2 1 ATOM 7927 N N . LEU B 1 466 ? 1.791 1.551 1.911 1.00 44.65 ? 466 LEU B N 1 ATOM 7928 C CA . LEU B 1 466 ? 1.844 2.608 2.940 1.00 43.43 ? 466 LEU B CA 1 ATOM 7929 C C . LEU B 1 466 ? 1.272 3.953 2.480 1.00 46.98 ? 466 LEU B C 1 ATOM 7930 O O . LEU B 1 466 ? 1.039 4.842 3.310 1.00 44.76 ? 466 LEU B O 1 ATOM 7931 C CB . LEU B 1 466 ? 3.285 2.858 3.436 1.00 43.17 ? 466 LEU B CB 1 ATOM 7932 C CG . LEU B 1 466 ? 4.162 1.706 3.895 1.00 47.92 ? 466 LEU B CG 1 ATOM 7933 C CD1 . LEU B 1 466 ? 5.442 2.232 4.493 1.00 47.20 ? 466 LEU B CD1 1 ATOM 7934 C CD2 . LEU B 1 466 ? 3.470 0.828 4.920 1.00 51.90 ? 466 LEU B CD2 1 ATOM 7935 N N . HIS B 1 467 ? 1.136 4.135 1.153 1.00 45.28 ? 467 HIS B N 1 ATOM 7936 C CA . HIS B 1 467 ? 0.679 5.398 0.560 1.00 45.39 ? 467 HIS B CA 1 ATOM 7937 C C . HIS B 1 467 ? -0.362 5.249 -0.563 1.00 50.07 ? 467 HIS B C 1 ATOM 7938 O O . HIS B 1 467 ? -1.099 6.193 -0.836 1.00 49.32 ? 467 HIS B O 1 ATOM 7939 C CB . HIS B 1 467 ? 1.888 6.177 0.010 1.00 45.87 ? 467 HIS B CB 1 ATOM 7940 C CG . HIS B 1 467 ? 3.034 6.313 0.970 1.00 48.81 ? 467 HIS B CG 1 ATOM 7941 N ND1 . HIS B 1 467 ? 3.053 7.300 1.944 1.00 50.15 ? 467 HIS B ND1 1 ATOM 7942 C CD2 . HIS B 1 467 ? 4.172 5.588 1.062 1.00 49.47 ? 467 HIS B CD2 1 ATOM 7943 C CE1 . HIS B 1 467 ? 4.196 7.140 2.590 1.00 48.81 ? 467 HIS B CE1 1 ATOM 7944 N NE2 . HIS B 1 467 ? 4.902 6.125 2.093 1.00 48.97 ? 467 HIS B NE2 1 ATOM 7945 N N . GLY B 1 468 ? -0.367 4.099 -1.229 1.00 47.58 ? 468 GLY B N 1 ATOM 7946 C CA . GLY B 1 468 ? -1.224 3.831 -2.376 1.00 47.70 ? 468 GLY B CA 1 ATOM 7947 C C . GLY B 1 468 ? -0.454 4.019 -3.674 1.00 53.16 ? 468 GLY B C 1 ATOM 7948 O O . GLY B 1 468 ? 0.731 4.382 -3.647 1.00 53.29 ? 468 GLY B O 1 ATOM 7949 N N . LEU B 1 469 ? -1.113 3.765 -4.831 1.00 48.80 ? 469 LEU B N 1 ATOM 7950 C CA . LEU B 1 469 ? -0.489 3.945 -6.147 1.00 48.00 ? 469 LEU B CA 1 ATOM 7951 C C . LEU B 1 469 ? -0.382 5.427 -6.517 1.00 52.86 ? 469 LEU B C 1 ATOM 7952 O O . LEU B 1 469 ? 0.311 5.764 -7.477 1.00 54.35 ? 469 LEU B O 1 ATOM 7953 C CB . LEU B 1 469 ? -1.225 3.166 -7.243 1.00 47.75 ? 469 LEU B CB 1 ATOM 7954 C CG . LEU B 1 469 ? -1.123 1.648 -7.178 1.00 52.57 ? 469 LEU B CG 1 ATOM 7955 C CD1 . LEU B 1 469 ? -2.333 0.997 -7.831 1.00 53.13 ? 469 LEU B CD1 1 ATOM 7956 C CD2 . LEU B 1 469 ? 0.176 1.145 -7.803 1.00 54.29 ? 469 LEU B CD2 1 ATOM 7957 N N . SER B 1 470 ? -1.057 6.312 -5.751 1.00 47.55 ? 470 SER B N 1 ATOM 7958 C CA . SER B 1 470 ? -1.037 7.767 -5.925 1.00 46.33 ? 470 SER B CA 1 ATOM 7959 C C . SER B 1 470 ? 0.356 8.343 -5.712 1.00 48.76 ? 470 SER B C 1 ATOM 7960 O O . SER B 1 470 ? 0.703 9.318 -6.373 1.00 48.59 ? 470 SER B O 1 ATOM 7961 C CB . SER B 1 470 ? -2.031 8.443 -4.985 1.00 49.17 ? 470 SER B CB 1 ATOM 7962 O OG . SER B 1 470 ? -2.182 7.742 -3.760 1.00 57.71 ? 470 SER B OG 1 ATOM 7963 N N . ALA B 1 471 ? 1.162 7.720 -4.815 1.00 44.07 ? 471 ALA B N 1 ATOM 7964 C CA . ALA B 1 471 ? 2.534 8.117 -4.477 1.00 43.48 ? 471 ALA B CA 1 ATOM 7965 C C . ALA B 1 471 ? 3.414 8.123 -5.717 1.00 48.29 ? 471 ALA B C 1 ATOM 7966 O O . ALA B 1 471 ? 4.321 8.951 -5.825 1.00 48.15 ? 471 ALA B O 1 ATOM 7967 C CB . ALA B 1 471 ? 3.115 7.169 -3.437 1.00 43.95 ? 471 ALA B CB 1 ATOM 7968 N N . PHE B 1 472 ? 3.127 7.207 -6.659 1.00 44.81 ? 472 PHE B N 1 ATOM 7969 C CA . PHE B 1 472 ? 3.863 7.052 -7.906 1.00 44.23 ? 472 PHE B CA 1 ATOM 7970 C C . PHE B 1 472 ? 3.373 8.012 -8.982 1.00 49.95 ? 472 PHE B C 1 ATOM 7971 O O . PHE B 1 472 ? 4.059 8.157 -10.000 1.00 50.75 ? 472 PHE B O 1 ATOM 7972 C CB . PHE B 1 472 ? 3.747 5.598 -8.415 1.00 45.53 ? 472 PHE B CB 1 ATOM 7973 C CG . PHE B 1 472 ? 4.058 4.496 -7.427 1.00 46.16 ? 472 PHE B CG 1 ATOM 7974 C CD1 . PHE B 1 472 ? 5.317 4.391 -6.850 1.00 48.41 ? 472 PHE B CD1 1 ATOM 7975 C CD2 . PHE B 1 472 ? 3.103 3.540 -7.106 1.00 47.83 ? 472 PHE B CD2 1 ATOM 7976 C CE1 . PHE B 1 472 ? 5.604 3.369 -5.940 1.00 49.01 ? 472 PHE B CE1 1 ATOM 7977 C CE2 . PHE B 1 472 ? 3.393 2.515 -6.199 1.00 50.39 ? 472 PHE B CE2 1 ATOM 7978 C CZ . PHE B 1 472 ? 4.643 2.437 -5.625 1.00 48.12 ? 472 PHE B CZ 1 ATOM 7979 N N . SER B 1 473 ? 2.194 8.668 -8.759 1.00 46.36 ? 473 SER B N 1 ATOM 7980 C CA . SER B 1 473 ? 1.525 9.572 -9.711 1.00 45.72 ? 473 SER B CA 1 ATOM 7981 C C . SER B 1 473 ? 1.403 11.025 -9.253 1.00 48.75 ? 473 SER B C 1 ATOM 7982 O O . SER B 1 473 ? 0.832 11.837 -9.985 1.00 50.05 ? 473 SER B O 1 ATOM 7983 C CB . SER B 1 473 ? 0.139 9.033 -10.073 1.00 49.41 ? 473 SER B CB 1 ATOM 7984 O OG . SER B 1 473 ? 0.169 7.684 -10.517 1.00 54.92 ? 473 SER B OG 1 ATOM 7985 N N . LEU B 1 474 ? 1.928 11.367 -8.068 1.00 43.64 ? 474 LEU B N 1 ATOM 7986 C CA . LEU B 1 474 ? 1.838 12.733 -7.542 1.00 42.72 ? 474 LEU B CA 1 ATOM 7987 C C . LEU B 1 474 ? 2.559 13.737 -8.403 1.00 46.56 ? 474 LEU B C 1 ATOM 7988 O O . LEU B 1 474 ? 3.614 13.425 -8.954 1.00 46.33 ? 474 LEU B O 1 ATOM 7989 C CB . LEU B 1 474 ? 2.352 12.846 -6.094 1.00 42.49 ? 474 LEU B CB 1 ATOM 7990 C CG . LEU B 1 474 ? 1.499 12.333 -4.917 1.00 46.50 ? 474 LEU B CG 1 ATOM 7991 C CD1 . LEU B 1 474 ? 1.791 13.155 -3.674 1.00 46.15 ? 474 LEU B CD1 1 ATOM 7992 C CD2 . LEU B 1 474 ? 0.003 12.362 -5.213 1.00 47.47 ? 474 LEU B CD2 1 ATOM 7993 N N . HIS B 1 475 ? 1.982 14.943 -8.512 1.00 43.89 ? 475 HIS B N 1 ATOM 7994 C CA . HIS B 1 475 ? 2.507 16.094 -9.261 1.00 44.42 ? 475 HIS B CA 1 ATOM 7995 C C . HIS B 1 475 ? 1.939 17.418 -8.696 1.00 49.72 ? 475 HIS B C 1 ATOM 7996 O O . HIS B 1 475 ? 1.118 17.386 -7.782 1.00 49.28 ? 475 HIS B O 1 ATOM 7997 C CB . HIS B 1 475 ? 2.206 15.967 -10.775 1.00 44.76 ? 475 HIS B CB 1 ATOM 7998 C CG . HIS B 1 475 ? 0.757 16.100 -11.115 1.00 48.09 ? 475 HIS B CG 1 ATOM 7999 N ND1 . HIS B 1 475 ? 0.181 17.337 -11.343 1.00 49.58 ? 475 HIS B ND1 1 ATOM 8000 C CD2 . HIS B 1 475 ? -0.192 15.144 -11.253 1.00 49.61 ? 475 HIS B CD2 1 ATOM 8001 C CE1 . HIS B 1 475 ? -1.097 17.096 -11.594 1.00 48.84 ? 475 HIS B CE1 1 ATOM 8002 N NE2 . HIS B 1 475 ? -1.364 15.791 -11.561 1.00 49.13 ? 475 HIS B NE2 1 ATOM 8003 N N . SER B 1 476 ? 2.351 18.570 -9.273 1.00 47.10 ? 476 SER B N 1 ATOM 8004 C CA . SER B 1 476 ? 1.901 19.917 -8.907 1.00 47.10 ? 476 SER B CA 1 ATOM 8005 C C . SER B 1 476 ? 1.908 20.136 -7.388 1.00 51.03 ? 476 SER B C 1 ATOM 8006 O O . SER B 1 476 ? 0.869 20.307 -6.743 1.00 50.36 ? 476 SER B O 1 ATOM 8007 C CB . SER B 1 476 ? 0.552 20.240 -9.550 1.00 50.63 ? 476 SER B CB 1 ATOM 8008 O OG . SER B 1 476 ? 0.623 20.078 -10.958 1.00 55.19 ? 476 SER B OG 1 ATOM 8009 N N . TYR B 1 477 ? 3.118 20.081 -6.830 1.00 48.04 ? 477 TYR B N 1 ATOM 8010 C CA . TYR B 1 477 ? 3.411 20.243 -5.407 1.00 47.29 ? 477 TYR B CA 1 ATOM 8011 C C . TYR B 1 477 ? 3.196 21.697 -4.958 1.00 51.02 ? 477 TYR B C 1 ATOM 8012 O O . TYR B 1 477 ? 3.335 22.606 -5.773 1.00 50.78 ? 477 TYR B O 1 ATOM 8013 C CB . TYR B 1 477 ? 4.849 19.747 -5.124 1.00 47.29 ? 477 TYR B CB 1 ATOM 8014 C CG . TYR B 1 477 ? 4.971 18.242 -5.190 1.00 47.48 ? 477 TYR B CG 1 ATOM 8015 C CD1 . TYR B 1 477 ? 4.726 17.455 -4.071 1.00 49.17 ? 477 TYR B CD1 1 ATOM 8016 C CD2 . TYR B 1 477 ? 5.296 17.600 -6.380 1.00 48.07 ? 477 TYR B CD2 1 ATOM 8017 C CE1 . TYR B 1 477 ? 4.816 16.066 -4.126 1.00 49.49 ? 477 TYR B CE1 1 ATOM 8018 C CE2 . TYR B 1 477 ? 5.385 16.210 -6.451 1.00 48.81 ? 477 TYR B CE2 1 ATOM 8019 C CZ . TYR B 1 477 ? 5.143 15.445 -5.319 1.00 53.43 ? 477 TYR B CZ 1 ATOM 8020 O OH . TYR B 1 477 ? 5.243 14.074 -5.357 1.00 48.39 ? 477 TYR B OH 1 ATOM 8021 N N . SER B 1 478 ? 2.845 21.925 -3.682 1.00 47.59 ? 478 SER B N 1 ATOM 8022 C CA . SER B 1 478 ? 2.622 23.292 -3.206 1.00 47.68 ? 478 SER B CA 1 ATOM 8023 C C . SER B 1 478 ? 3.888 24.163 -3.343 1.00 51.51 ? 478 SER B C 1 ATOM 8024 O O . SER B 1 478 ? 4.983 23.665 -3.086 1.00 51.35 ? 478 SER B O 1 ATOM 8025 C CB . SER B 1 478 ? 2.065 23.302 -1.784 1.00 52.14 ? 478 SER B CB 1 ATOM 8026 O OG . SER B 1 478 ? 3.002 22.865 -0.815 1.00 65.03 ? 478 SER B OG 1 ATOM 8027 N N . PRO B 1 479 ? 3.785 25.433 -3.803 1.00 47.66 ? 479 PRO B N 1 ATOM 8028 C CA . PRO B 1 479 ? 4.996 26.259 -3.949 1.00 47.01 ? 479 PRO B CA 1 ATOM 8029 C C . PRO B 1 479 ? 5.797 26.431 -2.660 1.00 50.61 ? 479 PRO B C 1 ATOM 8030 O O . PRO B 1 479 ? 7.005 26.609 -2.734 1.00 51.56 ? 479 PRO B O 1 ATOM 8031 C CB . PRO B 1 479 ? 4.461 27.593 -4.486 1.00 48.57 ? 479 PRO B CB 1 ATOM 8032 C CG . PRO B 1 479 ? 3.140 27.260 -5.092 1.00 53.28 ? 479 PRO B CG 1 ATOM 8033 C CD . PRO B 1 479 ? 2.581 26.194 -4.191 1.00 49.06 ? 479 PRO B CD 1 ATOM 8034 N N . GLY B 1 480 ? 5.135 26.330 -1.508 1.00 45.36 ? 480 GLY B N 1 ATOM 8035 C CA . GLY B 1 480 ? 5.782 26.408 -0.207 1.00 44.94 ? 480 GLY B CA 1 ATOM 8036 C C . GLY B 1 480 ? 6.719 25.239 -0.009 1.00 49.13 ? 480 GLY B C 1 ATOM 8037 O O . GLY B 1 480 ? 7.844 25.412 0.472 1.00 50.04 ? 480 GLY B O 1 ATOM 8038 N N . GLU B 1 481 ? 6.262 24.041 -0.436 1.00 44.27 ? 481 GLU B N 1 ATOM 8039 C CA . GLU B 1 481 ? 7.027 22.797 -0.393 1.00 43.32 ? 481 GLU B CA 1 ATOM 8040 C C . GLU B 1 481 ? 8.180 22.867 -1.390 1.00 46.96 ? 481 GLU B C 1 ATOM 8041 O O . GLU B 1 481 ? 9.339 22.693 -0.991 1.00 48.02 ? 481 GLU B O 1 ATOM 8042 C CB . GLU B 1 481 ? 6.119 21.574 -0.647 1.00 44.18 ? 481 GLU B CB 1 ATOM 8043 C CG . GLU B 1 481 ? 6.773 20.215 -0.427 1.00 46.45 ? 481 GLU B CG 1 ATOM 8044 C CD . GLU B 1 481 ? 7.474 19.978 0.897 1.00 52.04 ? 481 GLU B CD 1 ATOM 8045 O OE1 . GLU B 1 481 ? 7.077 20.600 1.910 1.00 41.06 ? 481 GLU B OE1 1 ATOM 8046 O OE2 . GLU B 1 481 ? 8.416 19.151 0.921 1.00 38.34 ? 481 GLU B OE2 1 ATOM 8047 N N . ILE B 1 482 ? 7.873 23.180 -2.664 1.00 41.59 ? 482 ILE B N 1 ATOM 8048 C CA . ILE B 1 482 ? 8.874 23.334 -3.724 1.00 41.01 ? 482 ILE B CA 1 ATOM 8049 C C . ILE B 1 482 ? 10.026 24.251 -3.267 1.00 47.29 ? 482 ILE B C 1 ATOM 8050 O O . ILE B 1 482 ? 11.190 23.883 -3.419 1.00 47.93 ? 482 ILE B O 1 ATOM 8051 C CB . ILE B 1 482 ? 8.239 23.813 -5.067 1.00 42.99 ? 482 ILE B CB 1 ATOM 8052 C CG1 . ILE B 1 482 ? 7.172 22.806 -5.572 1.00 42.27 ? 482 ILE B CG1 1 ATOM 8053 C CG2 . ILE B 1 482 ? 9.329 24.063 -6.122 1.00 43.51 ? 482 ILE B CG2 1 ATOM 8054 C CD1 . ILE B 1 482 ? 6.434 23.167 -6.851 1.00 42.64 ? 482 ILE B CD1 1 ATOM 8055 N N . ASN B 1 483 ? 9.691 25.407 -2.660 1.00 44.08 ? 483 ASN B N 1 ATOM 8056 C CA . ASN B 1 483 ? 10.661 26.396 -2.202 1.00 43.46 ? 483 ASN B CA 1 ATOM 8057 C C . ASN B 1 483 ? 11.504 25.927 -1.011 1.00 47.12 ? 483 ASN B C 1 ATOM 8058 O O . ASN B 1 483 ? 12.679 26.282 -0.945 1.00 47.20 ? 483 ASN B O 1 ATOM 8059 C CB . ASN B 1 483 ? 9.982 27.734 -1.926 1.00 43.68 ? 483 ASN B CB 1 ATOM 8060 C CG . ASN B 1 483 ? 9.336 28.384 -3.142 1.00 70.02 ? 483 ASN B CG 1 ATOM 8061 O OD1 . ASN B 1 483 ? 9.555 28.009 -4.311 1.00 56.46 ? 483 ASN B OD1 1 ATOM 8062 N ND2 . ASN B 1 483 ? 8.479 29.358 -2.888 1.00 69.09 ? 483 ASN B ND2 1 ATOM 8063 N N . ARG B 1 484 ? 10.933 25.120 -0.094 1.00 42.61 ? 484 ARG B N 1 ATOM 8064 C CA . ARG B 1 484 ? 11.677 24.573 1.051 1.00 41.38 ? 484 ARG B CA 1 ATOM 8065 C C . ARG B 1 484 ? 12.773 23.643 0.501 1.00 43.50 ? 484 ARG B C 1 ATOM 8066 O O . ARG B 1 484 ? 13.941 23.774 0.874 1.00 42.64 ? 484 ARG B O 1 ATOM 8067 C CB . ARG B 1 484 ? 10.727 23.828 2.028 1.00 39.14 ? 484 ARG B CB 1 ATOM 8068 C CG . ARG B 1 484 ? 11.423 23.241 3.268 1.00 39.87 ? 484 ARG B CG 1 ATOM 8069 C CD . ARG B 1 484 ? 10.486 22.934 4.425 1.00 38.62 ? 484 ARG B CD 1 ATOM 8070 N NE . ARG B 1 484 ? 9.603 21.803 4.155 1.00 41.03 ? 484 ARG B NE 1 ATOM 8071 C CZ . ARG B 1 484 ? 8.838 21.210 5.070 1.00 57.78 ? 484 ARG B CZ 1 ATOM 8072 N NH1 . ARG B 1 484 ? 8.854 21.625 6.331 1.00 53.62 ? 484 ARG B NH1 1 ATOM 8073 N NH2 . ARG B 1 484 ? 8.057 20.195 4.732 1.00 36.89 ? 484 ARG B NH2 1 ATOM 8074 N N . VAL B 1 485 ? 12.391 22.753 -0.433 1.00 39.96 ? 485 VAL B N 1 ATOM 8075 C CA . VAL B 1 485 ? 13.296 21.811 -1.095 1.00 40.13 ? 485 VAL B CA 1 ATOM 8076 C C . VAL B 1 485 ? 14.387 22.591 -1.851 1.00 44.58 ? 485 VAL B C 1 ATOM 8077 O O . VAL B 1 485 ? 15.563 22.416 -1.542 1.00 43.63 ? 485 VAL B O 1 ATOM 8078 C CB . VAL B 1 485 ? 12.542 20.778 -1.987 1.00 43.13 ? 485 VAL B CB 1 ATOM 8079 C CG1 . VAL B 1 485 ? 13.508 19.795 -2.638 1.00 42.00 ? 485 VAL B CG1 1 ATOM 8080 C CG2 . VAL B 1 485 ? 11.473 20.030 -1.180 1.00 42.93 ? 485 VAL B CG2 1 ATOM 8081 N N . ALA B 1 486 ? 13.987 23.505 -2.763 1.00 41.57 ? 486 ALA B N 1 ATOM 8082 C CA . ALA B 1 486 ? 14.886 24.337 -3.565 1.00 41.10 ? 486 ALA B CA 1 ATOM 8083 C C . ALA B 1 486 ? 15.924 25.050 -2.713 1.00 46.71 ? 486 ALA B C 1 ATOM 8084 O O . ALA B 1 486 ? 17.111 24.913 -2.990 1.00 46.84 ? 486 ALA B O 1 ATOM 8085 C CB . ALA B 1 486 ? 14.089 25.332 -4.381 1.00 41.71 ? 486 ALA B CB 1 ATOM 8086 N N . SER B 1 487 ? 15.486 25.758 -1.657 1.00 45.40 ? 487 SER B N 1 ATOM 8087 C CA . SER B 1 487 ? 16.343 26.474 -0.705 1.00 46.68 ? 487 SER B CA 1 ATOM 8088 C C . SER B 1 487 ? 17.364 25.517 -0.035 1.00 52.39 ? 487 SER B C 1 ATOM 8089 O O . SER B 1 487 ? 18.552 25.850 0.054 1.00 50.90 ? 487 SER B O 1 ATOM 8090 C CB . SER B 1 487 ? 15.486 27.198 0.339 1.00 50.97 ? 487 SER B CB 1 ATOM 8091 O OG . SER B 1 487 ? 16.155 27.451 1.568 1.00 60.87 ? 487 SER B OG 1 ATOM 8092 N N . CYS B 1 488 ? 16.887 24.322 0.397 1.00 51.10 ? 488 CYS B N 1 ATOM 8093 C CA . CYS B 1 488 ? 17.685 23.266 1.032 1.00 51.63 ? 488 CYS B CA 1 ATOM 8094 C C . CYS B 1 488 ? 18.778 22.783 0.076 1.00 50.30 ? 488 CYS B C 1 ATOM 8095 O O . CYS B 1 488 ? 19.930 22.669 0.477 1.00 49.03 ? 488 CYS B O 1 ATOM 8096 C CB . CYS B 1 488 ? 16.783 22.119 1.490 1.00 53.87 ? 488 CYS B CB 1 ATOM 8097 S SG . CYS B 1 488 ? 17.666 20.595 1.929 1.00 58.82 ? 488 CYS B SG 1 ATOM 8098 N N . LEU B 1 489 ? 18.414 22.544 -1.197 1.00 44.84 ? 489 LEU B N 1 ATOM 8099 C CA . LEU B 1 489 ? 19.319 22.132 -2.272 1.00 43.16 ? 489 LEU B CA 1 ATOM 8100 C C . LEU B 1 489 ? 20.396 23.176 -2.471 1.00 45.92 ? 489 LEU B C 1 ATOM 8101 O O . LEU B 1 489 ? 21.532 22.837 -2.805 1.00 47.07 ? 489 LEU B O 1 ATOM 8102 C CB . LEU B 1 489 ? 18.572 21.913 -3.605 1.00 42.85 ? 489 LEU B CB 1 ATOM 8103 C CG . LEU B 1 489 ? 17.420 20.903 -3.674 1.00 46.81 ? 489 LEU B CG 1 ATOM 8104 C CD1 . LEU B 1 489 ? 17.208 20.448 -5.077 1.00 46.64 ? 489 LEU B CD1 1 ATOM 8105 C CD2 . LEU B 1 489 ? 17.670 19.692 -2.819 1.00 49.88 ? 489 LEU B CD2 1 ATOM 8106 N N . ARG B 1 490 ? 20.058 24.447 -2.249 1.00 40.10 ? 490 ARG B N 1 ATOM 8107 C CA . ARG B 1 490 ? 21.053 25.505 -2.358 1.00 38.51 ? 490 ARG B CA 1 ATOM 8108 C C . ARG B 1 490 ? 21.957 25.459 -1.140 1.00 40.28 ? 490 ARG B C 1 ATOM 8109 O O . ARG B 1 490 ? 23.166 25.416 -1.305 1.00 39.96 ? 490 ARG B O 1 ATOM 8110 C CB . ARG B 1 490 ? 20.403 26.880 -2.531 1.00 35.00 ? 490 ARG B CB 1 ATOM 8111 C CG . ARG B 1 490 ? 19.856 27.083 -3.931 1.00 34.93 ? 490 ARG B CG 1 ATOM 8112 C CD . ARG B 1 490 ? 19.282 28.460 -4.128 1.00 33.30 ? 490 ARG B CD 1 ATOM 8113 N NE . ARG B 1 490 ? 17.978 28.614 -3.482 1.00 32.64 ? 490 ARG B NE 1 ATOM 8114 C CZ . ARG B 1 490 ? 16.823 28.405 -4.099 1.00 46.22 ? 490 ARG B CZ 1 ATOM 8115 N NH1 . ARG B 1 490 ? 15.677 28.576 -3.451 1.00 39.24 ? 490 ARG B NH1 1 ATOM 8116 N NH2 . ARG B 1 490 ? 16.802 28.029 -5.371 1.00 29.12 ? 490 ARG B NH2 1 ATOM 8117 N N . LYS B 1 491 ? 21.367 25.394 0.063 1.00 35.75 ? 491 LYS B N 1 ATOM 8118 C CA . LYS B 1 491 ? 22.070 25.359 1.343 1.00 35.65 ? 491 LYS B CA 1 ATOM 8119 C C . LYS B 1 491 ? 23.192 24.325 1.347 1.00 41.96 ? 491 LYS B C 1 ATOM 8120 O O . LYS B 1 491 ? 24.349 24.694 1.517 1.00 40.93 ? 491 LYS B O 1 ATOM 8121 C CB . LYS B 1 491 ? 21.073 25.144 2.513 1.00 36.78 ? 491 LYS B CB 1 ATOM 8122 C CG . LYS B 1 491 ? 21.722 25.063 3.889 1.00 31.61 ? 491 LYS B CG 1 ATOM 8123 C CD . LYS B 1 491 ? 20.734 25.184 5.039 1.00 37.73 ? 491 LYS B CD 1 ATOM 8124 C CE . LYS B 1 491 ? 19.926 23.950 5.346 1.00 44.66 ? 491 LYS B CE 1 ATOM 8125 N NZ . LYS B 1 491 ? 18.538 24.045 4.815 1.00 57.74 ? 491 LYS B NZ 1 ATOM 8126 N N . LEU B 1 492 ? 22.849 23.051 1.096 1.00 40.77 ? 492 LEU B N 1 ATOM 8127 C CA . LEU B 1 492 ? 23.777 21.913 1.068 1.00 40.97 ? 492 LEU B CA 1 ATOM 8128 C C . LEU B 1 492 ? 24.645 21.812 -0.207 1.00 44.13 ? 492 LEU B C 1 ATOM 8129 O O . LEU B 1 492 ? 25.723 21.218 -0.170 1.00 42.71 ? 492 LEU B O 1 ATOM 8130 C CB . LEU B 1 492 ? 23.007 20.601 1.304 1.00 41.01 ? 492 LEU B CB 1 ATOM 8131 C CG . LEU B 1 492 ? 22.337 20.440 2.666 1.00 44.90 ? 492 LEU B CG 1 ATOM 8132 C CD1 . LEU B 1 492 ? 21.163 19.488 2.578 1.00 44.99 ? 492 LEU B CD1 1 ATOM 8133 C CD2 . LEU B 1 492 ? 23.326 19.972 3.707 1.00 46.59 ? 492 LEU B CD2 1 ATOM 8134 N N . GLY B 1 493 ? 24.176 22.394 -1.304 1.00 41.84 ? 493 GLY B N 1 ATOM 8135 C CA . GLY B 1 493 ? 24.890 22.373 -2.579 1.00 42.20 ? 493 GLY B CA 1 ATOM 8136 C C . GLY B 1 493 ? 24.548 21.137 -3.381 1.00 46.74 ? 493 GLY B C 1 ATOM 8137 O O . GLY B 1 493 ? 25.421 20.521 -4.013 1.00 46.09 ? 493 GLY B O 1 ATOM 8138 N N . VAL B 1 494 ? 23.270 20.749 -3.307 1.00 42.93 ? 494 VAL B N 1 ATOM 8139 C CA . VAL B 1 494 ? 22.709 19.592 -3.993 1.00 42.97 ? 494 VAL B CA 1 ATOM 8140 C C . VAL B 1 494 ? 22.371 20.036 -5.429 1.00 47.34 ? 494 VAL B C 1 ATOM 8141 O O . VAL B 1 494 ? 21.794 21.122 -5.601 1.00 47.01 ? 494 VAL B O 1 ATOM 8142 C CB . VAL B 1 494 ? 21.464 19.031 -3.232 1.00 47.04 ? 494 VAL B CB 1 ATOM 8143 C CG1 . VAL B 1 494 ? 20.841 17.837 -3.951 1.00 47.26 ? 494 VAL B CG1 1 ATOM 8144 C CG2 . VAL B 1 494 ? 21.803 18.659 -1.796 1.00 46.75 ? 494 VAL B CG2 1 ATOM 8145 N N . PRO B 1 495 ? 22.709 19.238 -6.472 1.00 43.49 ? 495 PRO B N 1 ATOM 8146 C CA . PRO B 1 495 ? 22.341 19.639 -7.839 1.00 43.43 ? 495 PRO B CA 1 ATOM 8147 C C . PRO B 1 495 ? 20.837 19.935 -7.951 1.00 47.41 ? 495 PRO B C 1 ATOM 8148 O O . PRO B 1 495 ? 20.054 19.304 -7.230 1.00 46.90 ? 495 PRO B O 1 ATOM 8149 C CB . PRO B 1 495 ? 22.761 18.432 -8.683 1.00 45.17 ? 495 PRO B CB 1 ATOM 8150 C CG . PRO B 1 495 ? 23.836 17.772 -7.889 1.00 49.59 ? 495 PRO B CG 1 ATOM 8151 C CD . PRO B 1 495 ? 23.401 17.932 -6.469 1.00 45.05 ? 495 PRO B CD 1 ATOM 8152 N N . PRO B 1 496 ? 20.406 20.937 -8.762 1.00 43.18 ? 496 PRO B N 1 ATOM 8153 C CA . PRO B 1 496 ? 18.965 21.259 -8.823 1.00 42.48 ? 496 PRO B CA 1 ATOM 8154 C C . PRO B 1 496 ? 18.096 20.123 -9.357 1.00 46.07 ? 496 PRO B C 1 ATOM 8155 O O . PRO B 1 496 ? 18.602 19.242 -10.053 1.00 47.11 ? 496 PRO B O 1 ATOM 8156 C CB . PRO B 1 496 ? 18.911 22.509 -9.711 1.00 43.92 ? 496 PRO B CB 1 ATOM 8157 C CG . PRO B 1 496 ? 20.148 22.464 -10.512 1.00 47.99 ? 496 PRO B CG 1 ATOM 8158 C CD . PRO B 1 496 ? 21.192 21.819 -9.649 1.00 43.70 ? 496 PRO B CD 1 ATOM 8159 N N . LEU B 1 497 ? 16.790 20.154 -9.026 1.00 40.50 ? 497 LEU B N 1 ATOM 8160 C CA . LEU B 1 497 ? 15.772 19.175 -9.417 1.00 39.44 ? 497 LEU B CA 1 ATOM 8161 C C . LEU B 1 497 ? 15.790 18.824 -10.907 1.00 44.01 ? 497 LEU B C 1 ATOM 8162 O O . LEU B 1 497 ? 15.606 17.655 -11.234 1.00 44.41 ? 497 LEU B O 1 ATOM 8163 C CB . LEU B 1 497 ? 14.365 19.625 -8.974 1.00 39.31 ? 497 LEU B CB 1 ATOM 8164 C CG . LEU B 1 497 ? 14.149 19.856 -7.460 1.00 43.39 ? 497 LEU B CG 1 ATOM 8165 C CD1 . LEU B 1 497 ? 12.988 20.779 -7.215 1.00 42.95 ? 497 LEU B CD1 1 ATOM 8166 C CD2 . LEU B 1 497 ? 13.971 18.532 -6.694 1.00 44.29 ? 497 LEU B CD2 1 ATOM 8167 N N . ARG B 1 498 ? 16.058 19.800 -11.804 1.00 40.78 ? 498 ARG B N 1 ATOM 8168 C CA . ARG B 1 498 ? 16.146 19.521 -13.245 1.00 41.04 ? 498 ARG B CA 1 ATOM 8169 C C . ARG B 1 498 ? 17.276 18.518 -13.535 1.00 46.73 ? 498 ARG B C 1 ATOM 8170 O O . ARG B 1 498 ? 17.105 17.649 -14.400 1.00 47.02 ? 498 ARG B O 1 ATOM 8171 C CB . ARG B 1 498 ? 16.271 20.797 -14.108 1.00 40.49 ? 498 ARG B CB 1 ATOM 8172 C CG . ARG B 1 498 ? 17.466 21.673 -13.768 1.00 54.66 ? 498 ARG B CG 1 ATOM 8173 C CD . ARG B 1 498 ? 17.890 22.585 -14.892 1.00 62.38 ? 498 ARG B CD 1 ATOM 8174 N NE . ARG B 1 498 ? 19.066 23.370 -14.505 1.00 73.34 ? 498 ARG B NE 1 ATOM 8175 C CZ . ARG B 1 498 ? 20.318 23.067 -14.841 1.00 91.71 ? 498 ARG B CZ 1 ATOM 8176 N NH1 . ARG B 1 498 ? 20.574 22.002 -15.593 1.00 78.68 ? 498 ARG B NH1 1 ATOM 8177 N NH2 . ARG B 1 498 ? 21.323 23.834 -14.436 1.00 82.18 ? 498 ARG B NH2 1 ATOM 8178 N N . VAL B 1 499 ? 18.396 18.602 -12.766 1.00 43.08 ? 499 VAL B N 1 ATOM 8179 C CA . VAL B 1 499 ? 19.542 17.677 -12.872 1.00 42.53 ? 499 VAL B CA 1 ATOM 8180 C C . VAL B 1 499 ? 19.082 16.254 -12.463 1.00 46.85 ? 499 VAL B C 1 ATOM 8181 O O . VAL B 1 499 ? 19.397 15.278 -13.160 1.00 47.43 ? 499 VAL B O 1 ATOM 8182 C CB . VAL B 1 499 ? 20.781 18.168 -12.061 1.00 44.47 ? 499 VAL B CB 1 ATOM 8183 C CG1 . VAL B 1 499 ? 21.910 17.142 -12.076 1.00 43.58 ? 499 VAL B CG1 1 ATOM 8184 C CG2 . VAL B 1 499 ? 21.271 19.516 -12.575 1.00 43.76 ? 499 VAL B CG2 1 ATOM 8185 N N . TRP B 1 500 ? 18.285 16.164 -11.375 1.00 41.14 ? 500 TRP B N 1 ATOM 8186 C CA . TRP B 1 500 ? 17.762 14.904 -10.857 1.00 40.20 ? 500 TRP B CA 1 ATOM 8187 C C . TRP B 1 500 ? 16.747 14.257 -11.789 1.00 44.92 ? 500 TRP B C 1 ATOM 8188 O O . TRP B 1 500 ? 16.749 13.031 -11.887 1.00 45.77 ? 500 TRP B O 1 ATOM 8189 C CB . TRP B 1 500 ? 17.223 15.055 -9.432 1.00 38.33 ? 500 TRP B CB 1 ATOM 8190 C CG . TRP B 1 500 ? 18.311 15.377 -8.443 1.00 38.87 ? 500 TRP B CG 1 ATOM 8191 C CD1 . TRP B 1 500 ? 18.598 16.600 -7.913 1.00 41.63 ? 500 TRP B CD1 1 ATOM 8192 C CD2 . TRP B 1 500 ? 19.316 14.478 -7.946 1.00 38.33 ? 500 TRP B CD2 1 ATOM 8193 N NE1 . TRP B 1 500 ? 19.700 16.514 -7.092 1.00 40.71 ? 500 TRP B NE1 1 ATOM 8194 C CE2 . TRP B 1 500 ? 20.156 15.222 -7.086 1.00 41.95 ? 500 TRP B CE2 1 ATOM 8195 C CE3 . TRP B 1 500 ? 19.582 13.111 -8.130 1.00 39.20 ? 500 TRP B CE3 1 ATOM 8196 C CZ2 . TRP B 1 500 ? 21.236 14.644 -6.406 1.00 41.09 ? 500 TRP B CZ2 1 ATOM 8197 C CZ3 . TRP B 1 500 ? 20.651 12.541 -7.455 1.00 40.31 ? 500 TRP B CZ3 1 ATOM 8198 C CH2 . TRP B 1 500 ? 21.463 13.301 -6.603 1.00 40.80 ? 500 TRP B CH2 1 ATOM 8199 N N . ARG B 1 501 ? 15.921 15.055 -12.504 1.00 40.78 ? 501 ARG B N 1 ATOM 8200 C CA . ARG B 1 501 ? 14.948 14.539 -13.486 1.00 39.89 ? 501 ARG B CA 1 ATOM 8201 C C . ARG B 1 501 ? 15.716 13.911 -14.667 1.00 43.66 ? 501 ARG B C 1 ATOM 8202 O O . ARG B 1 501 ? 15.312 12.863 -15.176 1.00 43.17 ? 501 ARG B O 1 ATOM 8203 C CB . ARG B 1 501 ? 14.011 15.665 -13.970 1.00 38.46 ? 501 ARG B CB 1 ATOM 8204 C CG . ARG B 1 501 ? 13.017 15.297 -15.087 1.00 45.82 ? 501 ARG B CG 1 ATOM 8205 C CD . ARG B 1 501 ? 12.111 16.445 -15.503 1.00 52.48 ? 501 ARG B CD 1 ATOM 8206 N NE . ARG B 1 501 ? 11.274 16.934 -14.399 1.00 65.49 ? 501 ARG B NE 1 ATOM 8207 C CZ . ARG B 1 501 ? 11.404 18.122 -13.805 1.00 76.59 ? 501 ARG B CZ 1 ATOM 8208 N NH1 . ARG B 1 501 ? 12.361 18.966 -14.186 1.00 61.97 ? 501 ARG B NH1 1 ATOM 8209 N NH2 . ARG B 1 501 ? 10.591 18.470 -12.817 1.00 57.46 ? 501 ARG B NH2 1 ATOM 8210 N N . HIS B 1 502 ? 16.829 14.549 -15.079 1.00 40.01 ? 502 HIS B N 1 ATOM 8211 C CA . HIS B 1 502 ? 17.680 14.074 -16.163 1.00 39.92 ? 502 HIS B CA 1 ATOM 8212 C C . HIS B 1 502 ? 18.363 12.758 -15.741 1.00 43.22 ? 502 HIS B C 1 ATOM 8213 O O . HIS B 1 502 ? 18.413 11.797 -16.516 1.00 43.02 ? 502 HIS B O 1 ATOM 8214 C CB . HIS B 1 502 ? 18.709 15.153 -16.555 1.00 41.15 ? 502 HIS B CB 1 ATOM 8215 C CG . HIS B 1 502 ? 19.580 14.726 -17.687 1.00 45.58 ? 502 HIS B CG 1 ATOM 8216 N ND1 . HIS B 1 502 ? 19.093 14.651 -18.982 1.00 48.14 ? 502 HIS B ND1 1 ATOM 8217 C CD2 . HIS B 1 502 ? 20.852 14.262 -17.674 1.00 48.46 ? 502 HIS B CD2 1 ATOM 8218 C CE1 . HIS B 1 502 ? 20.087 14.174 -19.718 1.00 47.94 ? 502 HIS B CE1 1 ATOM 8219 N NE2 . HIS B 1 502 ? 21.170 13.929 -18.978 1.00 48.35 ? 502 HIS B NE2 1 ATOM 8220 N N . ARG B 1 503 ? 18.829 12.710 -14.485 1.00 38.83 ? 503 ARG B N 1 ATOM 8221 C CA . ARG B 1 503 ? 19.467 11.544 -13.892 1.00 38.14 ? 503 ARG B CA 1 ATOM 8222 C C . ARG B 1 503 ? 18.467 10.378 -13.697 1.00 43.71 ? 503 ARG B C 1 ATOM 8223 O O . ARG B 1 503 ? 18.846 9.224 -13.901 1.00 44.06 ? 503 ARG B O 1 ATOM 8224 C CB . ARG B 1 503 ? 20.141 11.926 -12.566 1.00 33.99 ? 503 ARG B CB 1 ATOM 8225 C CG . ARG B 1 503 ? 21.405 12.748 -12.724 1.00 26.49 ? 503 ARG B CG 1 ATOM 8226 C CD . ARG B 1 503 ? 22.003 13.021 -11.373 1.00 29.77 ? 503 ARG B CD 1 ATOM 8227 N NE . ARG B 1 503 ? 23.324 13.647 -11.467 1.00 42.67 ? 503 ARG B NE 1 ATOM 8228 C CZ . ARG B 1 503 ? 23.828 14.459 -10.544 1.00 56.86 ? 503 ARG B CZ 1 ATOM 8229 N NH1 . ARG B 1 503 ? 23.122 14.769 -9.468 1.00 53.79 ? 503 ARG B NH1 1 ATOM 8230 N NH2 . ARG B 1 503 ? 25.027 14.993 -10.706 1.00 41.67 ? 503 ARG B NH2 1 ATOM 8231 N N . ALA B 1 504 ? 17.203 10.678 -13.330 1.00 40.11 ? 504 ALA B N 1 ATOM 8232 C CA . ALA B 1 504 ? 16.158 9.668 -13.126 1.00 40.55 ? 504 ALA B CA 1 ATOM 8233 C C . ALA B 1 504 ? 15.736 8.959 -14.427 1.00 45.06 ? 504 ALA B C 1 ATOM 8234 O O . ALA B 1 504 ? 15.335 7.792 -14.389 1.00 42.89 ? 504 ALA B O 1 ATOM 8235 C CB . ALA B 1 504 ? 14.955 10.279 -12.444 1.00 41.30 ? 504 ALA B CB 1 ATOM 8236 N N . ARG B 1 505 ? 15.831 9.670 -15.568 1.00 43.46 ? 505 ARG B N 1 ATOM 8237 C CA . ARG B 1 505 ? 15.543 9.136 -16.906 1.00 43.87 ? 505 ARG B CA 1 ATOM 8238 C C . ARG B 1 505 ? 16.551 8.009 -17.194 1.00 47.50 ? 505 ARG B C 1 ATOM 8239 O O . ARG B 1 505 ? 16.151 6.929 -17.634 1.00 47.61 ? 505 ARG B O 1 ATOM 8240 C CB . ARG B 1 505 ? 15.659 10.244 -17.970 1.00 45.14 ? 505 ARG B CB 1 ATOM 8241 C CG . ARG B 1 505 ? 14.481 11.205 -17.999 1.00 54.78 ? 505 ARG B CG 1 ATOM 8242 C CD . ARG B 1 505 ? 14.686 12.300 -19.020 1.00 62.33 ? 505 ARG B CD 1 ATOM 8243 N NE . ARG B 1 505 ? 13.468 13.094 -19.191 1.00 76.58 ? 505 ARG B NE 1 ATOM 8244 C CZ . ARG B 1 505 ? 13.348 14.376 -18.857 1.00 93.23 ? 505 ARG B CZ 1 ATOM 8245 N NH1 . ARG B 1 505 ? 14.385 15.041 -18.361 1.00 80.56 ? 505 ARG B NH1 1 ATOM 8246 N NH2 . ARG B 1 505 ? 12.195 15.008 -19.037 1.00 78.48 ? 505 ARG B NH2 1 ATOM 8247 N N . SER B 1 506 ? 17.844 8.254 -16.873 1.00 42.48 ? 506 SER B N 1 ATOM 8248 C CA . SER B 1 506 ? 18.944 7.305 -17.002 1.00 41.07 ? 506 SER B CA 1 ATOM 8249 C C . SER B 1 506 ? 18.732 6.114 -16.071 1.00 44.87 ? 506 SER B C 1 ATOM 8250 O O . SER B 1 506 ? 18.796 4.975 -16.529 1.00 45.56 ? 506 SER B O 1 ATOM 8251 C CB . SER B 1 506 ? 20.271 7.988 -16.694 1.00 42.72 ? 506 SER B CB 1 ATOM 8252 O OG . SER B 1 506 ? 21.297 7.039 -16.449 1.00 49.29 ? 506 SER B OG 1 ATOM 8253 N N . VAL B 1 507 ? 18.471 6.371 -14.773 1.00 40.90 ? 507 VAL B N 1 ATOM 8254 C CA . VAL B 1 507 ? 18.228 5.324 -13.771 1.00 40.50 ? 507 VAL B CA 1 ATOM 8255 C C . VAL B 1 507 ? 17.077 4.414 -14.258 1.00 45.98 ? 507 VAL B C 1 ATOM 8256 O O . VAL B 1 507 ? 17.244 3.199 -14.326 1.00 46.53 ? 507 VAL B O 1 ATOM 8257 C CB . VAL B 1 507 ? 17.981 5.908 -12.357 1.00 43.49 ? 507 VAL B CB 1 ATOM 8258 C CG1 . VAL B 1 507 ? 17.714 4.797 -11.348 1.00 43.78 ? 507 VAL B CG1 1 ATOM 8259 C CG2 . VAL B 1 507 ? 19.157 6.764 -11.898 1.00 42.65 ? 507 VAL B CG2 1 ATOM 8260 N N . ARG B 1 508 ? 15.964 5.028 -14.682 1.00 42.31 ? 508 ARG B N 1 ATOM 8261 C CA . ARG B 1 508 ? 14.785 4.379 -15.237 1.00 41.45 ? 508 ARG B CA 1 ATOM 8262 C C . ARG B 1 508 ? 15.113 3.578 -16.494 1.00 46.77 ? 508 ARG B C 1 ATOM 8263 O O . ARG B 1 508 ? 14.584 2.482 -16.651 1.00 47.98 ? 508 ARG B O 1 ATOM 8264 C CB . ARG B 1 508 ? 13.729 5.427 -15.573 1.00 38.52 ? 508 ARG B CB 1 ATOM 8265 C CG . ARG B 1 508 ? 12.363 4.846 -15.766 1.00 39.22 ? 508 ARG B CG 1 ATOM 8266 C CD . ARG B 1 508 ? 11.433 5.876 -16.340 1.00 39.91 ? 508 ARG B CD 1 ATOM 8267 N NE . ARG B 1 508 ? 10.173 5.259 -16.736 1.00 47.76 ? 508 ARG B NE 1 ATOM 8268 C CZ . ARG B 1 508 ? 9.994 4.604 -17.875 1.00 58.14 ? 508 ARG B CZ 1 ATOM 8269 N NH1 . ARG B 1 508 ? 10.998 4.465 -18.735 1.00 40.79 ? 508 ARG B NH1 1 ATOM 8270 N NH2 . ARG B 1 508 ? 8.818 4.067 -18.157 1.00 43.57 ? 508 ARG B NH2 1 ATOM 8271 N N . ALA B 1 509 ? 15.936 4.117 -17.396 1.00 43.47 ? 509 ALA B N 1 ATOM 8272 C CA . ALA B 1 509 ? 16.302 3.403 -18.620 1.00 44.34 ? 509 ALA B CA 1 ATOM 8273 C C . ALA B 1 509 ? 17.160 2.168 -18.290 1.00 51.95 ? 509 ALA B C 1 ATOM 8274 O O . ALA B 1 509 ? 16.923 1.091 -18.856 1.00 53.35 ? 509 ALA B O 1 ATOM 8275 C CB . ALA B 1 509 ? 17.037 4.325 -19.577 1.00 45.00 ? 509 ALA B CB 1 ATOM 8276 N N . ARG B 1 510 ? 18.112 2.322 -17.332 1.00 47.84 ? 510 ARG B N 1 ATOM 8277 C CA . ARG B 1 510 ? 19.000 1.271 -16.836 1.00 47.32 ? 510 ARG B CA 1 ATOM 8278 C C . ARG B 1 510 ? 18.190 0.166 -16.144 1.00 52.70 ? 510 ARG B C 1 ATOM 8279 O O . ARG B 1 510 ? 18.527 -1.011 -16.282 1.00 52.97 ? 510 ARG B O 1 ATOM 8280 C CB . ARG B 1 510 ? 20.005 1.854 -15.824 1.00 45.27 ? 510 ARG B CB 1 ATOM 8281 C CG . ARG B 1 510 ? 21.196 2.563 -16.426 1.00 50.81 ? 510 ARG B CG 1 ATOM 8282 C CD . ARG B 1 510 ? 21.712 3.658 -15.529 1.00 57.33 ? 510 ARG B CD 1 ATOM 8283 N NE . ARG B 1 510 ? 22.713 3.192 -14.570 1.00 66.41 ? 510 ARG B NE 1 ATOM 8284 C CZ . ARG B 1 510 ? 23.325 3.987 -13.694 1.00 83.90 ? 510 ARG B CZ 1 ATOM 8285 N NH1 . ARG B 1 510 ? 23.039 5.283 -13.649 1.00 71.77 ? 510 ARG B NH1 1 ATOM 8286 N NH2 . ARG B 1 510 ? 24.228 3.492 -12.857 1.00 71.91 ? 510 ARG B NH2 1 ATOM 8287 N N . LEU B 1 511 ? 17.140 0.552 -15.382 1.00 49.21 ? 511 LEU B N 1 ATOM 8288 C CA . LEU B 1 511 ? 16.272 -0.358 -14.631 1.00 48.84 ? 511 LEU B CA 1 ATOM 8289 C C . LEU B 1 511 ? 15.379 -1.193 -15.517 1.00 52.37 ? 511 LEU B C 1 ATOM 8290 O O . LEU B 1 511 ? 15.124 -2.349 -15.179 1.00 52.45 ? 511 LEU B O 1 ATOM 8291 C CB . LEU B 1 511 ? 15.409 0.391 -13.600 1.00 48.87 ? 511 LEU B CB 1 ATOM 8292 C CG . LEU B 1 511 ? 16.038 0.736 -12.253 1.00 52.81 ? 511 LEU B CG 1 ATOM 8293 C CD1 . LEU B 1 511 ? 15.290 1.866 -11.599 1.00 52.35 ? 511 LEU B CD1 1 ATOM 8294 C CD2 . LEU B 1 511 ? 16.061 -0.464 -11.318 1.00 54.87 ? 511 LEU B CD2 1 ATOM 8295 N N . LEU B 1 512 ? 14.867 -0.621 -16.620 1.00 48.93 ? 512 LEU B N 1 ATOM 8296 C CA . LEU B 1 512 ? 14.010 -1.386 -17.535 1.00 48.70 ? 512 LEU B CA 1 ATOM 8297 C C . LEU B 1 512 ? 14.823 -2.504 -18.197 1.00 52.88 ? 512 LEU B C 1 ATOM 8298 O O . LEU B 1 512 ? 14.379 -3.651 -18.192 1.00 52.00 ? 512 LEU B O 1 ATOM 8299 C CB . LEU B 1 512 ? 13.319 -0.494 -18.590 1.00 48.20 ? 512 LEU B CB 1 ATOM 8300 C CG . LEU B 1 512 ? 12.341 0.582 -18.093 1.00 51.66 ? 512 LEU B CG 1 ATOM 8301 C CD1 . LEU B 1 512 ? 11.870 1.429 -19.232 1.00 51.14 ? 512 LEU B CD1 1 ATOM 8302 C CD2 . LEU B 1 512 ? 11.134 -0.014 -17.380 1.00 52.80 ? 512 LEU B CD2 1 ATOM 8303 N N . SER B 1 513 ? 16.051 -2.168 -18.668 1.00 50.24 ? 513 SER B N 1 ATOM 8304 C CA . SER B 1 513 ? 17.030 -3.048 -19.316 1.00 50.53 ? 513 SER B CA 1 ATOM 8305 C C . SER B 1 513 ? 17.351 -4.298 -18.487 1.00 58.02 ? 513 SER B C 1 ATOM 8306 O O . SER B 1 513 ? 17.561 -5.363 -19.067 1.00 58.22 ? 513 SER B O 1 ATOM 8307 C CB . SER B 1 513 ? 18.320 -2.281 -19.615 1.00 53.33 ? 513 SER B CB 1 ATOM 8308 O OG . SER B 1 513 ? 18.107 -1.165 -20.466 1.00 59.85 ? 513 SER B OG 1 ATOM 8309 N N . GLN B 1 514 ? 17.381 -4.173 -17.137 1.00 56.93 ? 514 GLN B N 1 ATOM 8310 C CA . GLN B 1 514 ? 17.663 -5.275 -16.194 1.00 57.29 ? 514 GLN B CA 1 ATOM 8311 C C . GLN B 1 514 ? 16.503 -6.301 -16.111 1.00 62.06 ? 514 GLN B C 1 ATOM 8312 O O . GLN B 1 514 ? 16.737 -7.468 -15.771 1.00 61.53 ? 514 GLN B O 1 ATOM 8313 C CB . GLN B 1 514 ? 17.976 -4.734 -14.785 1.00 58.38 ? 514 GLN B CB 1 ATOM 8314 C CG . GLN B 1 514 ? 19.222 -3.867 -14.679 1.00 67.99 ? 514 GLN B CG 1 ATOM 8315 C CD . GLN B 1 514 ? 20.406 -4.607 -14.121 1.00 89.48 ? 514 GLN B CD 1 ATOM 8316 O OE1 . GLN B 1 514 ? 20.320 -5.319 -13.113 1.00 84.87 ? 514 GLN B OE1 1 ATOM 8317 N NE2 . GLN B 1 514 ? 21.561 -4.405 -14.736 1.00 85.38 ? 514 GLN B NE2 1 ATOM 8318 N N . GLY B 1 515 ? 15.277 -5.842 -16.393 1.00 58.57 ? 515 GLY B N 1 ATOM 8319 C CA . GLY B 1 515 ? 14.064 -6.652 -16.346 1.00 58.36 ? 515 GLY B CA 1 ATOM 8320 C C . GLY B 1 515 ? 13.667 -7.079 -14.942 1.00 63.25 ? 515 GLY B C 1 ATOM 8321 O O . GLY B 1 515 ? 14.378 -6.799 -13.965 1.00 64.07 ? 515 GLY B O 1 ATOM 8322 N N . GLY B 1 516 ? 12.530 -7.763 -14.848 1.00 58.02 ? 516 GLY B N 1 ATOM 8323 C CA . GLY B 1 516 ? 11.999 -8.275 -13.591 1.00 57.07 ? 516 GLY B CA 1 ATOM 8324 C C . GLY B 1 516 ? 11.506 -7.203 -12.643 1.00 60.50 ? 516 GLY B C 1 ATOM 8325 O O . GLY B 1 516 ? 10.752 -6.311 -13.044 1.00 60.14 ? 516 GLY B O 1 ATOM 8326 N N . ARG B 1 517 ? 11.927 -7.296 -11.364 1.00 56.99 ? 517 ARG B N 1 ATOM 8327 C CA . ARG B 1 517 ? 11.555 -6.342 -10.311 1.00 56.33 ? 517 ARG B CA 1 ATOM 8328 C C . ARG B 1 517 ? 12.215 -4.990 -10.574 1.00 60.75 ? 517 ARG B C 1 ATOM 8329 O O . ARG B 1 517 ? 11.620 -3.961 -10.248 1.00 61.54 ? 517 ARG B O 1 ATOM 8330 C CB . ARG B 1 517 ? 11.892 -6.867 -8.901 1.00 54.14 ? 517 ARG B CB 1 ATOM 8331 C CG . ARG B 1 517 ? 11.012 -8.033 -8.421 1.00 54.16 ? 517 ARG B CG 1 ATOM 8332 C CD . ARG B 1 517 ? 11.275 -8.429 -6.969 1.00 50.24 ? 517 ARG B CD 1 ATOM 8333 N NE . ARG B 1 517 ? 12.641 -8.922 -6.758 1.00 59.23 ? 517 ARG B NE 1 ATOM 8334 C CZ . ARG B 1 517 ? 13.276 -8.919 -5.588 1.00 73.43 ? 517 ARG B CZ 1 ATOM 8335 N NH1 . ARG B 1 517 ? 12.681 -8.435 -4.503 1.00 58.37 ? 517 ARG B NH1 1 ATOM 8336 N NH2 . ARG B 1 517 ? 14.518 -9.383 -5.498 1.00 59.12 ? 517 ARG B NH2 1 ATOM 8337 N N . ALA B 1 518 ? 13.418 -4.995 -11.208 1.00 55.94 ? 518 ALA B N 1 ATOM 8338 C CA . ALA B 1 518 ? 14.152 -3.791 -11.608 1.00 54.86 ? 518 ALA B CA 1 ATOM 8339 C C . ALA B 1 518 ? 13.307 -2.975 -12.583 1.00 57.95 ? 518 ALA B C 1 ATOM 8340 O O . ALA B 1 518 ? 13.173 -1.767 -12.391 1.00 57.70 ? 518 ALA B O 1 ATOM 8341 C CB . ALA B 1 518 ? 15.480 -4.161 -12.239 1.00 55.19 ? 518 ALA B CB 1 ATOM 8342 N N . ALA B 1 519 ? 12.678 -3.643 -13.578 1.00 53.45 ? 519 ALA B N 1 ATOM 8343 C CA . ALA B 1 519 ? 11.794 -2.989 -14.542 1.00 52.98 ? 519 ALA B CA 1 ATOM 8344 C C . ALA B 1 519 ? 10.538 -2.459 -13.835 1.00 56.75 ? 519 ALA B C 1 ATOM 8345 O O . ALA B 1 519 ? 10.040 -1.396 -14.202 1.00 56.39 ? 519 ALA B O 1 ATOM 8346 C CB . ALA B 1 519 ? 11.420 -3.946 -15.655 1.00 53.56 ? 519 ALA B CB 1 ATOM 8347 N N . THR B 1 520 ? 10.067 -3.159 -12.784 1.00 53.40 ? 520 THR B N 1 ATOM 8348 C CA . THR B 1 520 ? 8.911 -2.726 -11.980 1.00 52.74 ? 520 THR B CA 1 ATOM 8349 C C . THR B 1 520 ? 9.282 -1.443 -11.210 1.00 53.72 ? 520 THR B C 1 ATOM 8350 O O . THR B 1 520 ? 8.507 -0.488 -11.236 1.00 52.31 ? 520 THR B O 1 ATOM 8351 C CB . THR B 1 520 ? 8.375 -3.894 -11.134 1.00 59.85 ? 520 THR B CB 1 ATOM 8352 O OG1 . THR B 1 520 ? 7.763 -4.836 -12.019 1.00 58.71 ? 520 THR B OG1 1 ATOM 8353 C CG2 . THR B 1 520 ? 7.377 -3.454 -10.061 1.00 57.09 ? 520 THR B CG2 1 ATOM 8354 N N . CYS B 1 521 ? 10.495 -1.410 -10.591 1.00 48.78 ? 521 CYS B N 1 ATOM 8355 C CA . CYS B 1 521 ? 11.054 -0.241 -9.898 1.00 47.79 ? 521 CYS B CA 1 ATOM 8356 C C . CYS B 1 521 ? 11.145 0.932 -10.889 1.00 52.29 ? 521 CYS B C 1 ATOM 8357 O O . CYS B 1 521 ? 10.662 2.018 -10.577 1.00 52.83 ? 521 CYS B O 1 ATOM 8358 C CB . CYS B 1 521 ? 12.419 -0.559 -9.290 1.00 47.56 ? 521 CYS B CB 1 ATOM 8359 S SG . CYS B 1 521 ? 12.349 -1.366 -7.671 1.00 51.32 ? 521 CYS B SG 1 ATOM 8360 N N . GLY B 1 522 ? 11.697 0.680 -12.085 1.00 47.82 ? 522 GLY B N 1 ATOM 8361 C CA . GLY B 1 522 ? 11.822 1.667 -13.149 1.00 47.67 ? 522 GLY B CA 1 ATOM 8362 C C . GLY B 1 522 ? 10.478 2.204 -13.600 1.00 53.55 ? 522 GLY B C 1 ATOM 8363 O O . GLY B 1 522 ? 10.327 3.416 -13.807 1.00 54.13 ? 522 GLY B O 1 ATOM 8364 N N . LYS B 1 523 ? 9.476 1.308 -13.702 1.00 49.98 ? 523 LYS B N 1 ATOM 8365 C CA . LYS B 1 523 ? 8.120 1.659 -14.118 1.00 50.13 ? 523 LYS B CA 1 ATOM 8366 C C . LYS B 1 523 ? 7.368 2.566 -13.116 1.00 52.75 ? 523 LYS B C 1 ATOM 8367 O O . LYS B 1 523 ? 6.734 3.518 -13.555 1.00 52.64 ? 523 LYS B O 1 ATOM 8368 C CB . LYS B 1 523 ? 7.294 0.394 -14.451 1.00 53.83 ? 523 LYS B CB 1 ATOM 8369 C CG . LYS B 1 523 ? 5.965 0.669 -15.177 1.00 70.00 ? 523 LYS B CG 1 ATOM 8370 C CD . LYS B 1 523 ? 4.796 -0.168 -14.648 1.00 75.42 ? 523 LYS B CD 1 ATOM 8371 C CE . LYS B 1 523 ? 3.620 -0.135 -15.600 1.00 78.89 ? 523 LYS B CE 1 ATOM 8372 N NZ . LYS B 1 523 ? 2.528 -1.048 -15.171 1.00 80.61 ? 523 LYS B NZ 1 ATOM 8373 N N . TYR B 1 524 ? 7.412 2.266 -11.800 1.00 47.99 ? 524 TYR B N 1 ATOM 8374 C CA . TYR B 1 524 ? 6.682 3.031 -10.776 1.00 46.94 ? 524 TYR B CA 1 ATOM 8375 C C . TYR B 1 524 ? 7.460 4.182 -10.138 1.00 49.13 ? 524 TYR B C 1 ATOM 8376 O O . TYR B 1 524 ? 6.944 5.303 -10.059 1.00 49.06 ? 524 TYR B O 1 ATOM 8377 C CB . TYR B 1 524 ? 6.142 2.102 -9.672 1.00 48.20 ? 524 TYR B CB 1 ATOM 8378 C CG . TYR B 1 524 ? 5.123 1.096 -10.156 1.00 50.35 ? 524 TYR B CG 1 ATOM 8379 C CD1 . TYR B 1 524 ? 3.778 1.430 -10.258 1.00 52.65 ? 524 TYR B CD1 1 ATOM 8380 C CD2 . TYR B 1 524 ? 5.495 -0.202 -10.468 1.00 51.64 ? 524 TYR B CD2 1 ATOM 8381 C CE1 . TYR B 1 524 ? 2.837 0.513 -10.719 1.00 53.55 ? 524 TYR B CE1 1 ATOM 8382 C CE2 . TYR B 1 524 ? 4.562 -1.135 -10.910 1.00 53.15 ? 524 TYR B CE2 1 ATOM 8383 C CZ . TYR B 1 524 ? 3.232 -0.773 -11.038 1.00 62.38 ? 524 TYR B CZ 1 ATOM 8384 O OH . TYR B 1 524 ? 2.320 -1.690 -11.508 1.00 66.37 ? 524 TYR B OH 1 ATOM 8385 N N . LEU B 1 525 ? 8.686 3.900 -9.658 1.00 43.79 ? 525 LEU B N 1 ATOM 8386 C CA . LEU B 1 525 ? 9.508 4.871 -8.929 1.00 42.08 ? 525 LEU B CA 1 ATOM 8387 C C . LEU B 1 525 ? 10.028 6.005 -9.784 1.00 45.47 ? 525 LEU B C 1 ATOM 8388 O O . LEU B 1 525 ? 10.351 7.052 -9.229 1.00 45.36 ? 525 LEU B O 1 ATOM 8389 C CB . LEU B 1 525 ? 10.676 4.206 -8.153 1.00 41.24 ? 525 LEU B CB 1 ATOM 8390 C CG . LEU B 1 525 ? 10.352 2.996 -7.259 1.00 44.28 ? 525 LEU B CG 1 ATOM 8391 C CD1 . LEU B 1 525 ? 11.584 2.461 -6.612 1.00 43.59 ? 525 LEU B CD1 1 ATOM 8392 C CD2 . LEU B 1 525 ? 9.307 3.321 -6.225 1.00 44.95 ? 525 LEU B CD2 1 ATOM 8393 N N . PHE B 1 526 ? 10.121 5.821 -11.114 1.00 41.39 ? 526 PHE B N 1 ATOM 8394 C CA . PHE B 1 526 ? 10.673 6.871 -11.973 1.00 40.23 ? 526 PHE B CA 1 ATOM 8395 C C . PHE B 1 526 ? 9.781 7.275 -13.158 1.00 41.91 ? 526 PHE B C 1 ATOM 8396 O O . PHE B 1 526 ? 10.218 8.076 -13.984 1.00 39.58 ? 526 PHE B O 1 ATOM 8397 C CB . PHE B 1 526 ? 12.086 6.491 -12.432 1.00 41.71 ? 526 PHE B CB 1 ATOM 8398 C CG . PHE B 1 526 ? 13.024 6.288 -11.266 1.00 43.46 ? 526 PHE B CG 1 ATOM 8399 C CD1 . PHE B 1 526 ? 13.417 7.361 -10.474 1.00 46.91 ? 526 PHE B CD1 1 ATOM 8400 C CD2 . PHE B 1 526 ? 13.453 5.017 -10.912 1.00 45.64 ? 526 PHE B CD2 1 ATOM 8401 C CE1 . PHE B 1 526 ? 14.232 7.164 -9.358 1.00 47.80 ? 526 PHE B CE1 1 ATOM 8402 C CE2 . PHE B 1 526 ? 14.305 4.827 -9.819 1.00 48.40 ? 526 PHE B CE2 1 ATOM 8403 C CZ . PHE B 1 526 ? 14.692 5.900 -9.053 1.00 46.62 ? 526 PHE B CZ 1 ATOM 8404 N N . ASN B 1 527 ? 8.498 6.834 -13.172 1.00 38.92 ? 527 ASN B N 1 ATOM 8405 C CA . ASN B 1 527 ? 7.531 7.196 -14.216 1.00 38.43 ? 527 ASN B CA 1 ATOM 8406 C C . ASN B 1 527 ? 7.356 8.698 -14.328 1.00 43.51 ? 527 ASN B C 1 ATOM 8407 O O . ASN B 1 527 ? 7.094 9.211 -15.419 1.00 44.54 ? 527 ASN B O 1 ATOM 8408 C CB . ASN B 1 527 ? 6.191 6.541 -13.982 1.00 36.63 ? 527 ASN B CB 1 ATOM 8409 C CG . ASN B 1 527 ? 5.625 5.940 -15.245 1.00 58.96 ? 527 ASN B CG 1 ATOM 8410 O OD1 . ASN B 1 527 ? 6.320 5.250 -16.006 1.00 46.54 ? 527 ASN B OD1 1 ATOM 8411 N ND2 . ASN B 1 527 ? 4.334 6.137 -15.461 1.00 55.30 ? 527 ASN B ND2 1 ATOM 8412 N N . TRP B 1 528 ? 7.558 9.406 -13.205 1.00 38.77 ? 528 TRP B N 1 ATOM 8413 C CA . TRP B 1 528 ? 7.485 10.858 -13.131 1.00 37.60 ? 528 TRP B CA 1 ATOM 8414 C C . TRP B 1 528 ? 8.499 11.549 -14.040 1.00 44.57 ? 528 TRP B C 1 ATOM 8415 O O . TRP B 1 528 ? 8.222 12.665 -14.485 1.00 44.38 ? 528 TRP B O 1 ATOM 8416 C CB . TRP B 1 528 ? 7.653 11.327 -11.681 1.00 34.83 ? 528 TRP B CB 1 ATOM 8417 C CG . TRP B 1 528 ? 8.930 10.887 -11.029 1.00 34.96 ? 528 TRP B CG 1 ATOM 8418 C CD1 . TRP B 1 528 ? 9.111 9.787 -10.247 1.00 37.68 ? 528 TRP B CD1 1 ATOM 8419 C CD2 . TRP B 1 528 ? 10.191 11.573 -11.055 1.00 34.51 ? 528 TRP B CD2 1 ATOM 8420 N NE1 . TRP B 1 528 ? 10.403 9.741 -9.786 1.00 36.86 ? 528 TRP B NE1 1 ATOM 8421 C CE2 . TRP B 1 528 ? 11.092 10.819 -10.273 1.00 38.13 ? 528 TRP B CE2 1 ATOM 8422 C CE3 . TRP B 1 528 ? 10.653 12.750 -11.674 1.00 35.38 ? 528 TRP B CE3 1 ATOM 8423 C CZ2 . TRP B 1 528 ? 12.429 11.190 -10.109 1.00 37.19 ? 528 TRP B CZ2 1 ATOM 8424 C CZ3 . TRP B 1 528 ? 11.978 13.105 -11.526 1.00 36.58 ? 528 TRP B CZ3 1 ATOM 8425 C CH2 . TRP B 1 528 ? 12.846 12.345 -10.733 1.00 37.28 ? 528 TRP B CH2 1 ATOM 8426 N N . ALA B 1 529 ? 9.671 10.890 -14.300 1.00 43.82 ? 529 ALA B N 1 ATOM 8427 C CA . ALA B 1 529 ? 10.794 11.412 -15.083 1.00 45.03 ? 529 ALA B CA 1 ATOM 8428 C C . ALA B 1 529 ? 10.551 11.519 -16.583 1.00 55.35 ? 529 ALA B C 1 ATOM 8429 O O . ALA B 1 529 ? 11.122 12.406 -17.215 1.00 55.93 ? 529 ALA B O 1 ATOM 8430 C CB . ALA B 1 529 ? 12.044 10.605 -14.814 1.00 45.50 ? 529 ALA B CB 1 ATOM 8431 N N . VAL B 1 530 ? 9.699 10.657 -17.148 1.00 56.44 ? 530 VAL B N 1 ATOM 8432 C CA . VAL B 1 530 ? 9.381 10.646 -18.583 1.00 58.59 ? 530 VAL B CA 1 ATOM 8433 C C . VAL B 1 530 ? 8.108 11.438 -18.919 1.00 68.51 ? 530 VAL B C 1 ATOM 8434 O O . VAL B 1 530 ? 7.225 11.542 -18.066 1.00 67.60 ? 530 VAL B O 1 ATOM 8435 C CB . VAL B 1 530 ? 9.328 9.204 -19.160 1.00 62.57 ? 530 VAL B CB 1 ATOM 8436 C CG1 . VAL B 1 530 ? 10.713 8.569 -19.179 1.00 62.35 ? 530 VAL B CG1 1 ATOM 8437 C CG2 . VAL B 1 530 ? 8.321 8.316 -18.413 1.00 62.23 ? 530 VAL B CG2 1 ATOM 8438 N N . LYS B 1 531 ? 8.008 11.971 -20.173 1.00 70.16 ? 531 LYS B N 1 ATOM 8439 C CA . LYS B 1 531 ? 6.829 12.717 -20.657 1.00 71.89 ? 531 LYS B CA 1 ATOM 8440 C C . LYS B 1 531 ? 5.655 11.745 -20.894 1.00 80.58 ? 531 LYS B C 1 ATOM 8441 O O . LYS B 1 531 ? 4.567 11.940 -20.336 1.00 80.20 ? 531 LYS B O 1 ATOM 8442 C CB . LYS B 1 531 ? 7.143 13.521 -21.943 1.00 73.96 ? 531 LYS B CB 1 ATOM 8443 C CG . LYS B 1 531 ? 5.943 14.322 -22.485 1.00 84.32 ? 531 LYS B CG 1 ATOM 8444 C CD . LYS B 1 531 ? 6.243 15.045 -23.797 1.00 91.58 ? 531 LYS B CD 1 ATOM 8445 C CE . LYS B 1 531 ? 5.231 16.126 -24.143 1.00 95.70 ? 531 LYS B CE 1 ATOM 8446 N NZ . LYS B 1 531 ? 4.005 15.595 -24.803 1.00 94.93 ? 531 LYS B NZ 1 ATOM 8447 N N . THR B 1 532 ? 5.890 10.706 -21.727 1.00 80.28 ? 532 THR B N 1 ATOM 8448 C CA . THR B 1 532 ? 4.900 9.677 -22.058 1.00 81.48 ? 532 THR B CA 1 ATOM 8449 C C . THR B 1 532 ? 4.927 8.587 -20.973 1.00 86.57 ? 532 THR B C 1 ATOM 8450 O O . THR B 1 532 ? 5.774 7.688 -20.992 1.00 86.03 ? 532 THR B O 1 ATOM 8451 C CB . THR B 1 532 ? 5.038 9.180 -23.526 1.00 93.46 ? 532 THR B CB 1 ATOM 8452 O OG1 . THR B 1 532 ? 4.326 7.948 -23.690 1.00 93.90 ? 532 THR B OG1 1 ATOM 8453 C CG2 . THR B 1 532 ? 6.500 9.035 -23.994 1.00 92.57 ? 532 THR B CG2 1 ATOM 8454 N N . LYS B 1 533 ? 4.003 8.706 -20.007 1.00 84.33 ? 533 LYS B N 1 ATOM 8455 C CA . LYS B 1 533 ? 3.894 7.801 -18.866 1.00 84.78 ? 533 LYS B CA 1 ATOM 8456 C C . LYS B 1 533 ? 3.333 6.417 -19.230 1.00 91.57 ? 533 LYS B C 1 ATOM 8457 O O . LYS B 1 533 ? 2.944 6.179 -20.377 1.00 91.43 ? 533 LYS B O 1 ATOM 8458 C CB . LYS B 1 533 ? 3.098 8.459 -17.721 1.00 86.44 ? 533 LYS B CB 1 ATOM 8459 C CG . LYS B 1 533 ? 3.949 9.280 -16.749 1.00 87.34 ? 533 LYS B CG 1 ATOM 8460 C CD . LYS B 1 533 ? 4.057 10.747 -17.141 1.00 90.00 ? 533 LYS B CD 1 ATOM 8461 C CE . LYS B 1 533 ? 4.650 11.579 -16.034 1.00 93.75 ? 533 LYS B CE 1 ATOM 8462 N NZ . LYS B 1 533 ? 5.146 12.884 -16.543 1.00 101.12 ? 533 LYS B NZ 1 ATOM 8463 N N . LEU B 1 534 ? 3.319 5.506 -18.238 1.00 90.23 ? 534 LEU B N 1 ATOM 8464 C CA . LEU B 1 534 ? 2.874 4.114 -18.325 1.00 90.74 ? 534 LEU B CA 1 ATOM 8465 C C . LEU B 1 534 ? 1.675 3.853 -17.397 1.00 97.08 ? 534 LEU B C 1 ATOM 8466 O O . LEU B 1 534 ? 1.563 4.513 -16.358 1.00 96.79 ? 534 LEU B O 1 ATOM 8467 C CB . LEU B 1 534 ? 4.053 3.191 -17.945 1.00 90.49 ? 534 LEU B CB 1 ATOM 8468 C CG . LEU B 1 534 ? 5.006 2.774 -19.074 1.00 94.79 ? 534 LEU B CG 1 ATOM 8469 C CD1 . LEU B 1 534 ? 5.902 3.919 -19.528 1.00 94.93 ? 534 LEU B CD1 1 ATOM 8470 C CD2 . LEU B 1 534 ? 5.866 1.612 -18.651 1.00 96.89 ? 534 LEU B CD2 1 ATOM 8471 N N . LYS B 1 535 ? 0.787 2.889 -17.776 1.00 95.21 ? 535 LYS B N 1 ATOM 8472 C CA . LYS B 1 535 ? -0.401 2.485 -17.008 1.00 95.44 ? 535 LYS B CA 1 ATOM 8473 C C . LYS B 1 535 ? 0.020 1.778 -15.708 1.00 100.45 ? 535 LYS B C 1 ATOM 8474 O O . LYS B 1 535 ? 0.370 0.590 -15.718 1.00 99.55 ? 535 LYS B O 1 ATOM 8475 C CB . LYS B 1 535 ? -1.347 1.616 -17.850 1.00 97.61 ? 535 LYS B CB 1 ATOM 8476 C CG . LYS B 1 535 ? -2.649 1.308 -17.113 1.00 109.22 ? 535 LYS B CG 1 ATOM 8477 C CD . LYS B 1 535 ? -3.519 0.337 -17.856 1.00 116.82 ? 535 LYS B CD 1 ATOM 8478 C CE . LYS B 1 535 ? -4.889 0.234 -17.211 1.00 122.37 ? 535 LYS B CE 1 ATOM 8479 N NZ . LYS B 1 535 ? -5.876 -0.498 -18.061 1.00 126.21 ? 535 LYS B NZ 1 ATOM 8480 N N . LEU B 1 536 ? 0.031 2.543 -14.593 1.00 98.44 ? 536 LEU B N 1 ATOM 8481 C CA . LEU B 1 536 ? 0.437 2.067 -13.263 1.00 98.51 ? 536 LEU B CA 1 ATOM 8482 C C . LEU B 1 536 ? -0.696 1.308 -12.563 1.00 104.09 ? 536 LEU B C 1 ATOM 8483 O O . LEU B 1 536 ? -1.748 1.881 -12.263 1.00 103.53 ? 536 LEU B O 1 ATOM 8484 C CB . LEU B 1 536 ? 1.005 3.212 -12.387 1.00 98.12 ? 536 LEU B CB 1 ATOM 8485 C CG . LEU B 1 536 ? 2.149 4.057 -12.974 1.00 101.80 ? 536 LEU B CG 1 ATOM 8486 C CD1 . LEU B 1 536 ? 2.541 5.164 -12.030 1.00 101.54 ? 536 LEU B CD1 1 ATOM 8487 C CD2 . LEU B 1 536 ? 3.369 3.209 -13.317 1.00 103.57 ? 536 LEU B CD2 1 ATOM 8488 N N . THR B 1 537 ? -0.466 0.003 -12.333 1.00 102.00 ? 537 THR B N 1 ATOM 8489 C CA . THR B 1 537 ? -1.410 -0.959 -11.754 1.00 102.31 ? 537 THR B CA 1 ATOM 8490 C C . THR B 1 537 ? -0.912 -1.539 -10.391 1.00 108.00 ? 537 THR B C 1 ATOM 8491 O O . THR B 1 537 ? 0.233 -1.304 -10.028 1.00 107.81 ? 537 THR B O 1 ATOM 8492 C CB . THR B 1 537 ? -1.659 -2.078 -12.796 1.00 108.56 ? 537 THR B CB 1 ATOM 8493 O OG1 . THR B 1 537 ? -0.407 -2.572 -13.279 1.00 108.00 ? 537 THR B OG1 1 ATOM 8494 C CG2 . THR B 1 537 ? -2.521 -1.622 -13.954 1.00 106.78 ? 537 THR B CG2 1 ATOM 8495 N N . PRO B 1 538 ? -1.718 -2.310 -9.624 1.00 105.64 ? 538 PRO B N 1 ATOM 8496 C CA . PRO B 1 538 ? -1.214 -2.875 -8.354 1.00 109.56 ? 538 PRO B CA 1 ATOM 8497 C C . PRO B 1 538 ? -0.155 -3.968 -8.526 1.00 135.68 ? 538 PRO B C 1 ATOM 8498 O O . PRO B 1 538 ? -0.140 -4.677 -9.529 1.00 99.13 ? 538 PRO B O 1 ATOM 8499 C CB . PRO B 1 538 ? -2.475 -3.443 -7.689 1.00 110.82 ? 538 PRO B CB 1 ATOM 8500 C CG . PRO B 1 538 ? -3.617 -2.869 -8.453 1.00 114.15 ? 538 PRO B CG 1 ATOM 8501 C CD . PRO B 1 538 ? -3.127 -2.674 -9.832 1.00 108.72 ? 538 PRO B CD 1 ATOM 8502 N N . PHE B 1 551 ? 0.795 -1.806 10.328 1.00 64.23 ? 551 PHE B N 1 ATOM 8503 C CA . PHE B 1 551 ? 1.451 -1.089 11.419 1.00 64.17 ? 551 PHE B CA 1 ATOM 8504 C C . PHE B 1 551 ? 0.802 -1.367 12.781 1.00 68.64 ? 551 PHE B C 1 ATOM 8505 O O . PHE B 1 551 ? -0.424 -1.285 12.915 1.00 67.15 ? 551 PHE B O 1 ATOM 8506 C CB . PHE B 1 551 ? 1.511 0.419 11.133 1.00 66.02 ? 551 PHE B CB 1 ATOM 8507 C CG . PHE B 1 551 ? 2.761 0.893 10.422 1.00 68.12 ? 551 PHE B CG 1 ATOM 8508 C CD1 . PHE B 1 551 ? 3.951 1.077 11.116 1.00 72.18 ? 551 PHE B CD1 1 ATOM 8509 C CD2 . PHE B 1 551 ? 2.738 1.192 9.067 1.00 70.32 ? 551 PHE B CD2 1 ATOM 8510 C CE1 . PHE B 1 551 ? 5.103 1.532 10.455 1.00 73.14 ? 551 PHE B CE1 1 ATOM 8511 C CE2 . PHE B 1 551 ? 3.881 1.679 8.419 1.00 73.02 ? 551 PHE B CE2 1 ATOM 8512 C CZ . PHE B 1 551 ? 5.057 1.837 9.115 1.00 71.14 ? 551 PHE B CZ 1 ATOM 8513 N N . VAL B 1 552 ? 1.632 -1.696 13.796 1.00 66.68 ? 552 VAL B N 1 ATOM 8514 C CA . VAL B 1 552 ? 1.130 -2.002 15.138 1.00 66.98 ? 552 VAL B CA 1 ATOM 8515 C C . VAL B 1 552 ? 1.662 -1.010 16.187 1.00 69.04 ? 552 VAL B C 1 ATOM 8516 O O . VAL B 1 552 ? 0.850 -0.407 16.901 1.00 68.61 ? 552 VAL B O 1 ATOM 8517 C CB . VAL B 1 552 ? 1.352 -3.491 15.537 1.00 71.61 ? 552 VAL B CB 1 ATOM 8518 C CG1 . VAL B 1 552 ? 1.123 -3.721 17.033 1.00 71.50 ? 552 VAL B CG1 1 ATOM 8519 C CG2 . VAL B 1 552 ? 0.448 -4.412 14.719 1.00 71.61 ? 552 VAL B CG2 1 ATOM 8520 N N . ALA B 1 553 ? 3.005 -0.848 16.285 1.00 63.79 ? 553 ALA B N 1 ATOM 8521 C CA . ALA B 1 553 ? 3.641 0.041 17.267 1.00 62.90 ? 553 ALA B CA 1 ATOM 8522 C C . ALA B 1 553 ? 5.070 0.500 16.903 1.00 65.48 ? 553 ALA B C 1 ATOM 8523 O O . ALA B 1 553 ? 5.708 -0.058 16.002 1.00 64.88 ? 553 ALA B O 1 ATOM 8524 C CB . ALA B 1 553 ? 3.643 -0.628 18.641 1.00 63.72 ? 553 ALA B CB 1 ATOM 8525 N N . GLY B 1 554 ? 5.547 1.511 17.635 1.00 61.62 ? 554 GLY B N 1 ATOM 8526 C CA . GLY B 1 554 ? 6.884 2.080 17.515 1.00 61.16 ? 554 GLY B CA 1 ATOM 8527 C C . GLY B 1 554 ? 7.775 1.511 18.597 1.00 64.95 ? 554 GLY B C 1 ATOM 8528 O O . GLY B 1 554 ? 7.326 1.353 19.735 1.00 64.68 ? 554 GLY B O 1 ATOM 8529 N N . TYR B 1 555 ? 9.025 1.144 18.249 1.00 61.24 ? 555 TYR B N 1 ATOM 8530 C CA . TYR B 1 555 ? 9.968 0.517 19.191 1.00 60.85 ? 555 TYR B CA 1 ATOM 8531 C C . TYR B 1 555 ? 11.316 1.264 19.295 1.00 68.18 ? 555 TYR B C 1 ATOM 8532 O O . TYR B 1 555 ? 12.384 0.635 19.311 1.00 67.78 ? 555 TYR B O 1 ATOM 8533 C CB . TYR B 1 555 ? 10.159 -0.979 18.844 1.00 60.54 ? 555 TYR B CB 1 ATOM 8534 C CG . TYR B 1 555 ? 8.864 -1.763 18.806 1.00 59.88 ? 555 TYR B CG 1 ATOM 8535 C CD1 . TYR B 1 555 ? 8.298 -2.267 19.971 1.00 61.41 ? 555 TYR B CD1 1 ATOM 8536 C CD2 . TYR B 1 555 ? 8.195 -1.986 17.605 1.00 59.48 ? 555 TYR B CD2 1 ATOM 8537 C CE1 . TYR B 1 555 ? 7.095 -2.970 19.946 1.00 61.38 ? 555 TYR B CE1 1 ATOM 8538 C CE2 . TYR B 1 555 ? 6.992 -2.688 17.567 1.00 59.53 ? 555 TYR B CE2 1 ATOM 8539 C CZ . TYR B 1 555 ? 6.444 -3.177 18.741 1.00 63.47 ? 555 TYR B CZ 1 ATOM 8540 O OH . TYR B 1 555 ? 5.258 -3.872 18.713 1.00 59.15 ? 555 TYR B OH 1 ATOM 8541 N N . SER B 1 556 ? 11.250 2.612 19.379 1.00 67.61 ? 556 SER B N 1 ATOM 8542 C CA . SER B 1 556 ? 12.410 3.509 19.482 1.00 68.74 ? 556 SER B CA 1 ATOM 8543 C C . SER B 1 556 ? 13.176 3.281 20.788 1.00 74.06 ? 556 SER B C 1 ATOM 8544 O O . SER B 1 556 ? 12.656 3.563 21.875 1.00 73.65 ? 556 SER B O 1 ATOM 8545 C CB . SER B 1 556 ? 11.989 4.968 19.301 1.00 72.90 ? 556 SER B CB 1 ATOM 8546 O OG . SER B 1 556 ? 13.074 5.870 19.444 1.00 82.99 ? 556 SER B OG 1 ATOM 8547 N N . GLY B 1 557 ? 14.380 2.707 20.644 1.00 71.37 ? 557 GLY B N 1 ATOM 8548 C CA . GLY B 1 557 ? 15.279 2.329 21.733 1.00 71.33 ? 557 GLY B CA 1 ATOM 8549 C C . GLY B 1 557 ? 15.036 0.913 22.229 1.00 75.00 ? 557 GLY B C 1 ATOM 8550 O O . GLY B 1 557 ? 15.890 0.326 22.899 1.00 74.63 ? 557 GLY B O 1 ATOM 8551 N N . GLY B 1 558 ? 13.876 0.369 21.862 1.00 71.30 ? 558 GLY B N 1 ATOM 8552 C CA . GLY B 1 558 ? 13.381 -0.947 22.238 1.00 70.95 ? 558 GLY B CA 1 ATOM 8553 C C . GLY B 1 558 ? 14.158 -2.180 21.826 1.00 74.24 ? 558 GLY B C 1 ATOM 8554 O O . GLY B 1 558 ? 13.910 -3.246 22.390 1.00 74.03 ? 558 GLY B O 1 ATOM 8555 N N . ASP B 1 559 ? 15.078 -2.073 20.840 1.00 70.54 ? 559 ASP B N 1 ATOM 8556 C CA . ASP B 1 559 ? 15.884 -3.204 20.351 1.00 70.37 ? 559 ASP B CA 1 ATOM 8557 C C . ASP B 1 559 ? 14.941 -4.286 19.766 1.00 76.49 ? 559 ASP B C 1 ATOM 8558 O O . ASP B 1 559 ? 14.821 -5.366 20.332 1.00 76.61 ? 559 ASP B O 1 ATOM 8559 C CB . ASP B 1 559 ? 16.790 -3.755 21.497 1.00 71.38 ? 559 ASP B CB 1 ATOM 8560 C CG . ASP B 1 559 ? 17.889 -4.729 21.113 1.00 72.97 ? 559 ASP B CG 1 ATOM 8561 O OD1 . ASP B 1 559 ? 18.767 -4.343 20.324 1.00 74.28 ? 559 ASP B OD1 1 ATOM 8562 O OD2 . ASP B 1 559 ? 17.928 -5.845 21.689 1.00 71.67 ? 559 ASP B OD2 1 ATOM 8563 N N . ILE B 1 560 ? 14.225 -3.963 18.669 1.00 74.39 ? 560 ILE B N 1 ATOM 8564 C CA . ILE B 1 560 ? 13.257 -4.870 18.013 1.00 74.57 ? 560 ILE B CA 1 ATOM 8565 C C . ILE B 1 560 ? 13.545 -5.036 16.509 1.00 80.09 ? 560 ILE B C 1 ATOM 8566 O O . ILE B 1 560 ? 13.797 -4.044 15.820 1.00 79.67 ? 560 ILE B O 1 ATOM 8567 C CB . ILE B 1 560 ? 11.774 -4.438 18.297 1.00 77.34 ? 560 ILE B CB 1 ATOM 8568 C CG1 . ILE B 1 560 ? 11.406 -4.541 19.798 1.00 77.66 ? 560 ILE B CG1 1 ATOM 8569 C CG2 . ILE B 1 560 ? 10.744 -5.168 17.422 1.00 77.98 ? 560 ILE B CG2 1 ATOM 8570 C CD1 . ILE B 1 560 ? 11.658 -5.901 20.491 1.00 84.13 ? 560 ILE B CD1 1 ATOM 8571 N N . TYR B 1 561 ? 13.490 -6.292 16.013 1.00 77.84 ? 561 TYR B N 1 ATOM 8572 C CA . TYR B 1 561 ? 13.701 -6.617 14.605 1.00 78.54 ? 561 TYR B CA 1 ATOM 8573 C C . TYR B 1 561 ? 12.559 -7.457 14.020 1.00 83.03 ? 561 TYR B C 1 ATOM 8574 O O . TYR B 1 561 ? 12.229 -8.515 14.564 1.00 82.53 ? 561 TYR B O 1 ATOM 8575 C CB . TYR B 1 561 ? 15.065 -7.295 14.389 1.00 80.66 ? 561 TYR B CB 1 ATOM 8576 C CG . TYR B 1 561 ? 15.274 -7.837 12.991 1.00 83.83 ? 561 TYR B CG 1 ATOM 8577 C CD1 . TYR B 1 561 ? 15.806 -7.037 11.983 1.00 86.09 ? 561 TYR B CD1 1 ATOM 8578 C CD2 . TYR B 1 561 ? 14.933 -9.151 12.672 1.00 84.90 ? 561 TYR B CD2 1 ATOM 8579 C CE1 . TYR B 1 561 ? 15.983 -7.527 10.688 1.00 87.32 ? 561 TYR B CE1 1 ATOM 8580 C CE2 . TYR B 1 561 ? 15.098 -9.649 11.381 1.00 85.96 ? 561 TYR B CE2 1 ATOM 8581 C CZ . TYR B 1 561 ? 15.628 -8.836 10.393 1.00 93.13 ? 561 TYR B CZ 1 ATOM 8582 O OH . TYR B 1 561 ? 15.801 -9.344 9.132 1.00 93.58 ? 561 TYR B OH 1 ATOM 8583 N N . HIS B 1 562 ? 12.008 -7.004 12.870 1.00 79.84 ? 562 HIS B N 1 ATOM 8584 C CA . HIS B 1 562 ? 10.943 -7.682 12.128 1.00 104.33 ? 562 HIS B CA 1 ATOM 8585 C C . HIS B 1 562 ? 11.462 -8.206 10.784 1.00 124.56 ? 562 HIS B C 1 ATOM 8586 O O . HIS B 1 562 ? 12.282 -7.561 10.126 1.00 81.32 ? 562 HIS B O 1 ATOM 8587 C CB . HIS B 1 562 ? 9.757 -6.743 11.899 1.00 105.16 ? 562 HIS B CB 1 ATOM 8588 C CG . HIS B 1 562 ? 9.113 -6.248 13.155 1.00 108.60 ? 562 HIS B CG 1 ATOM 8589 N ND1 . HIS B 1 562 ? 8.262 -7.050 13.893 1.00 110.33 ? 562 HIS B ND1 1 ATOM 8590 C CD2 . HIS B 1 562 ? 9.191 -5.034 13.745 1.00 110.23 ? 562 HIS B CD2 1 ATOM 8591 C CE1 . HIS B 1 562 ? 7.860 -6.304 14.908 1.00 109.56 ? 562 HIS B CE1 1 ATOM 8592 N NE2 . HIS B 1 562 ? 8.392 -5.085 14.862 1.00 109.89 ? 562 HIS B NE2 1 HETATM 8593 ZN ZN . ZN C 2 . ? 30.313 -15.124 -15.050 1.00 93.48 2 601 ZN A ZN 1 HETATM 8594 C C1 . 28L D 3 . ? 54.467 -9.646 1.812 1.00 78.79 ? 602 28L A C1 1 HETATM 8595 S S2 . 28L D 3 . ? 53.054 -8.603 1.743 1.00 79.50 ? 602 28L A S2 1 HETATM 8596 N N3 . 28L D 3 . ? 52.047 -9.239 2.801 1.00 77.15 ? 602 28L A N3 1 HETATM 8597 C C4 . 28L D 3 . ? 52.161 -9.062 4.136 1.00 73.57 ? 602 28L A C4 1 HETATM 8598 C C5 . 28L D 3 . ? 51.127 -9.711 4.836 1.00 72.19 ? 602 28L A C5 1 HETATM 8599 C C6 . 28L D 3 . ? 50.994 -9.589 6.208 1.00 71.31 ? 602 28L A C6 1 HETATM 8600 C C7 . 28L D 3 . ? 53.078 -8.323 4.906 1.00 71.09 ? 602 28L A C7 1 HETATM 8601 C C8 . 28L D 3 . ? 52.949 -8.220 6.278 1.00 70.14 ? 602 28L A C8 1 HETATM 8602 C C9 . 28L D 3 . ? 51.901 -8.844 6.962 1.00 69.94 ? 602 28L A C9 1 HETATM 8603 C C10 . 28L D 3 . ? 51.741 -8.680 8.438 1.00 67.32 ? 602 28L A C10 1 HETATM 8604 C C11 . 28L D 3 . ? 52.699 -8.010 9.205 1.00 66.55 ? 602 28L A C11 1 HETATM 8605 N N12 . 28L D 3 . ? 52.701 -7.935 10.518 1.00 65.40 ? 602 28L A N12 1 HETATM 8606 C C13 . 28L D 3 . ? 50.633 -9.212 9.115 1.00 65.57 ? 602 28L A C13 1 HETATM 8607 C C14 . 28L D 3 . ? 50.569 -9.108 10.532 1.00 65.53 ? 602 28L A C14 1 HETATM 8608 C C15 . 28L D 3 . ? 51.664 -8.510 11.195 1.00 64.94 ? 602 28L A C15 1 HETATM 8609 C C16 . 28L D 3 . ? 51.708 -8.545 12.628 1.00 64.84 ? 602 28L A C16 1 HETATM 8610 C C17 . 28L D 3 . ? 52.877 -8.044 13.401 1.00 65.45 ? 602 28L A C17 1 HETATM 8611 C C18 . 28L D 3 . ? 53.678 -8.878 14.154 1.00 63.62 ? 602 28L A C18 1 HETATM 8612 C C19 . 28L D 3 . ? 54.893 -8.444 14.783 1.00 60.60 ? 602 28L A C19 1 HETATM 8613 C C20 . 28L D 3 . ? 55.187 -7.104 14.550 1.00 59.43 ? 602 28L A C20 1 HETATM 8614 O O21 . 28L D 3 . ? 56.401 -6.631 14.933 1.00 58.55 ? 602 28L A O21 1 HETATM 8615 C C22 . 28L D 3 . ? 57.426 -7.487 15.480 1.00 58.32 ? 602 28L A C22 1 HETATM 8616 N N23 . 28L D 3 . ? 54.467 -6.210 13.869 1.00 61.50 ? 602 28L A N23 1 HETATM 8617 C C24 . 28L D 3 . ? 53.242 -6.637 13.253 1.00 65.81 ? 602 28L A C24 1 HETATM 8618 O O25 . 28L D 3 . ? 52.537 -5.792 12.663 1.00 68.94 ? 602 28L A O25 1 HETATM 8619 C C26 . 28L D 3 . ? 50.634 -9.107 13.279 1.00 65.61 ? 602 28L A C26 1 HETATM 8620 C C27 . 28L D 3 . ? 49.488 -9.631 12.679 1.00 66.00 ? 602 28L A C27 1 HETATM 8621 C C28 . 28L D 3 . ? 48.324 -10.088 13.604 1.00 65.42 ? 602 28L A C28 1 HETATM 8622 C C29 . 28L D 3 . ? 48.783 -10.222 15.062 1.00 64.82 ? 602 28L A C29 1 HETATM 8623 C C30 . 28L D 3 . ? 47.188 -9.065 13.628 1.00 65.52 ? 602 28L A C30 1 HETATM 8624 C C31 . 28L D 3 . ? 47.741 -11.453 13.205 1.00 65.79 ? 602 28L A C31 1 HETATM 8625 C C32 . 28L D 3 . ? 49.474 -9.621 11.302 1.00 65.81 ? 602 28L A C32 1 HETATM 8626 O O33 . 28L D 3 . ? 48.349 -10.066 10.626 1.00 65.55 ? 602 28L A O33 1 HETATM 8627 C C34 . 28L D 3 . ? 47.453 -9.106 10.060 1.00 65.08 ? 602 28L A C34 1 HETATM 8628 O O35 . 28L D 3 . ? 52.460 -8.771 0.438 1.00 80.45 ? 602 28L A O35 1 HETATM 8629 O O36 . 28L D 3 . ? 53.492 -7.265 2.066 1.00 80.56 ? 602 28L A O36 1 HETATM 8630 ZN ZN . ZN E 2 . ? -12.704 14.813 37.987 1.00 90.69 2 601 ZN B ZN 1 HETATM 8631 C C1 . 28L F 3 . ? 11.597 9.201 21.542 1.00 72.34 ? 602 28L B C1 1 HETATM 8632 S S2 . 28L F 3 . ? 10.051 8.364 21.562 1.00 73.88 ? 602 28L B S2 1 HETATM 8633 N N3 . 28L F 3 . ? 9.151 9.146 20.499 1.00 77.26 ? 602 28L B N3 1 HETATM 8634 C C4 . 28L F 3 . ? 9.365 9.098 19.141 1.00 77.75 ? 602 28L B C4 1 HETATM 8635 C C5 . 28L F 3 . ? 8.408 9.826 18.408 1.00 77.61 ? 602 28L B C5 1 HETATM 8636 C C6 . 28L F 3 . ? 8.366 9.781 17.025 1.00 77.15 ? 602 28L B C6 1 HETATM 8637 C C7 . 28L F 3 . ? 10.326 8.393 18.390 1.00 76.64 ? 602 28L B C7 1 HETATM 8638 C C8 . 28L F 3 . ? 10.302 8.388 17.008 1.00 76.34 ? 602 28L B C8 1 HETATM 8639 C C9 . 28L F 3 . ? 9.311 9.061 16.293 1.00 76.78 ? 602 28L B C9 1 HETATM 8640 C C10 . 28L F 3 . ? 9.204 8.917 14.811 1.00 77.22 ? 602 28L B C10 1 HETATM 8641 C C11 . 28L F 3 . ? 10.211 8.294 14.065 1.00 78.61 ? 602 28L B C11 1 HETATM 8642 N N12 . 28L F 3 . ? 10.185 8.109 12.761 1.00 78.65 ? 602 28L B N12 1 HETATM 8643 C C13 . 28L F 3 . ? 8.051 9.320 14.123 1.00 76.22 ? 602 28L B C13 1 HETATM 8644 C C14 . 28L F 3 . ? 7.960 9.102 12.721 1.00 75.72 ? 602 28L B C14 1 HETATM 8645 C C15 . 28L F 3 . ? 9.077 8.515 12.074 1.00 77.29 ? 602 28L B C15 1 HETATM 8646 C C16 . 28L F 3 . ? 9.059 8.381 10.645 1.00 75.75 ? 602 28L B C16 1 HETATM 8647 C C17 . 28L F 3 . ? 10.240 7.937 9.854 1.00 74.99 ? 602 28L B C17 1 HETATM 8648 C C18 . 28L F 3 . ? 10.842 8.794 8.966 1.00 74.32 ? 602 28L B C18 1 HETATM 8649 C C19 . 28L F 3 . ? 12.101 8.532 8.361 1.00 74.28 ? 602 28L B C19 1 HETATM 8650 C C20 . 28L F 3 . ? 12.688 7.350 8.761 1.00 73.58 ? 602 28L B C20 1 HETATM 8651 O O21 . 28L F 3 . ? 13.983 7.309 8.359 1.00 73.23 ? 602 28L B O21 1 HETATM 8652 C C22 . 28L F 3 . ? 14.843 6.192 8.677 1.00 74.13 ? 602 28L B C22 1 HETATM 8653 N N23 . 28L F 3 . ? 12.170 6.391 9.563 1.00 74.19 ? 602 28L B N23 1 HETATM 8654 C C24 . 28L F 3 . ? 10.864 6.647 10.158 1.00 75.77 ? 602 28L B C24 1 HETATM 8655 O O25 . 28L F 3 . ? 10.337 5.763 10.861 1.00 76.82 ? 602 28L B O25 1 HETATM 8656 C C26 . 28L F 3 . ? 7.930 8.812 9.989 1.00 75.28 ? 602 28L B C26 1 HETATM 8657 C C27 . 28L F 3 . ? 6.803 9.393 10.570 1.00 74.22 ? 602 28L B C27 1 HETATM 8658 C C28 . 28L F 3 . ? 5.694 9.928 9.620 1.00 72.49 ? 602 28L B C28 1 HETATM 8659 C C29 . 28L F 3 . ? 6.144 9.891 8.149 1.00 71.73 ? 602 28L B C29 1 HETATM 8660 C C30 . 28L F 3 . ? 4.421 9.074 9.685 1.00 71.90 ? 602 28L B C30 1 HETATM 8661 C C31 . 28L F 3 . ? 5.328 11.390 9.915 1.00 72.06 ? 602 28L B C31 1 HETATM 8662 C C32 . 28L F 3 . ? 6.826 9.502 11.943 1.00 73.62 ? 602 28L B C32 1 HETATM 8663 O O33 . 28L F 3 . ? 5.710 9.979 12.613 1.00 71.76 ? 602 28L B O33 1 HETATM 8664 C C34 . 28L F 3 . ? 4.853 9.043 13.272 1.00 70.51 ? 602 28L B C34 1 HETATM 8665 O O35 . 28L F 3 . ? 9.495 8.529 22.883 1.00 73.06 ? 602 28L B O35 1 HETATM 8666 O O36 . 28L F 3 . ? 10.291 7.001 21.148 1.00 72.57 ? 602 28L B O36 1 HETATM 8667 O O . HOH G 4 . ? 28.729 -16.111 3.248 1.00 51.20 ? 701 HOH A O 1 HETATM 8668 O O . HOH G 4 . ? 70.774 12.407 5.544 1.00 14.53 ? 702 HOH A O 1 HETATM 8669 O O . HOH G 4 . ? 65.199 -9.174 12.378 1.00 20.33 ? 703 HOH A O 1 HETATM 8670 O O . HOH G 4 . ? 63.611 -3.574 -11.031 1.00 24.82 ? 704 HOH A O 1 HETATM 8671 O O . HOH G 4 . ? 64.762 5.098 -8.891 1.00 33.26 ? 705 HOH A O 1 HETATM 8672 O O . HOH G 4 . ? 62.538 0.996 9.346 1.00 50.59 ? 706 HOH A O 1 HETATM 8673 O O . HOH G 4 . ? 59.624 -2.099 -17.325 1.00 26.55 ? 707 HOH A O 1 HETATM 8674 O O . HOH G 4 . ? 53.434 -11.742 11.960 1.00 42.37 ? 708 HOH A O 1 HETATM 8675 O O . HOH G 4 . ? 49.607 -17.114 24.614 1.00 34.94 ? 709 HOH A O 1 HETATM 8676 O O . HOH G 4 . ? 44.621 11.988 -7.056 1.00 27.88 ? 710 HOH A O 1 HETATM 8677 O O . HOH G 4 . ? 61.852 -21.116 12.521 1.00 33.11 ? 711 HOH A O 1 HETATM 8678 O O . HOH G 4 . ? 72.945 -6.938 -0.084 1.00 40.90 ? 712 HOH A O 1 HETATM 8679 O O . HOH G 4 . ? 58.586 -16.881 10.845 1.00 35.42 ? 713 HOH A O 1 HETATM 8680 O O . HOH G 4 . ? 47.948 10.126 -2.602 1.00 20.46 ? 714 HOH A O 1 HETATM 8681 O O . HOH G 4 . ? 57.764 3.815 -1.781 1.00 30.03 ? 715 HOH A O 1 HETATM 8682 O O . HOH G 4 . ? 53.570 -31.187 0.208 1.00 39.39 ? 716 HOH A O 1 HETATM 8683 O O . HOH G 4 . ? 81.754 -11.913 23.324 1.00 34.90 ? 717 HOH A O 1 HETATM 8684 O O . HOH G 4 . ? 28.582 -12.688 13.022 1.00 44.40 ? 718 HOH A O 1 HETATM 8685 O O . HOH G 4 . ? 50.530 -0.797 -11.379 1.00 18.59 ? 719 HOH A O 1 HETATM 8686 O O . HOH G 4 . ? 79.584 -4.566 20.261 1.00 61.89 ? 720 HOH A O 1 HETATM 8687 O O . HOH G 4 . ? 39.091 -8.340 32.635 1.00 26.96 ? 721 HOH A O 1 HETATM 8688 O O . HOH G 4 . ? 66.265 -7.845 14.511 1.00 44.38 ? 722 HOH A O 1 HETATM 8689 O O . HOH G 4 . ? 51.253 -15.904 3.112 1.00 70.16 ? 723 HOH A O 1 HETATM 8690 O O . HOH G 4 . ? 41.387 -11.479 -18.520 1.00 16.77 ? 724 HOH A O 1 HETATM 8691 O O . HOH G 4 . ? 58.507 -13.444 -2.886 1.00 23.02 ? 725 HOH A O 1 HETATM 8692 O O . HOH G 4 . ? 53.770 -1.231 0.217 1.00 17.69 ? 726 HOH A O 1 HETATM 8693 O O . HOH G 4 . ? 49.260 -7.662 33.933 1.00 34.65 ? 727 HOH A O 1 HETATM 8694 O O . HOH G 4 . ? 42.004 11.807 2.952 1.00 40.45 ? 728 HOH A O 1 HETATM 8695 O O . HOH G 4 . ? 58.100 7.301 27.344 1.00 42.99 ? 729 HOH A O 1 HETATM 8696 O O . HOH G 4 . ? 61.740 -13.313 -20.281 1.00 23.97 ? 730 HOH A O 1 HETATM 8697 O O . HOH G 4 . ? 59.354 20.987 8.843 1.00 35.13 ? 731 HOH A O 1 HETATM 8698 O O . HOH G 4 . ? 62.156 -14.900 4.998 1.00 39.56 ? 732 HOH A O 1 HETATM 8699 O O . HOH G 4 . ? 75.329 -12.402 -19.272 1.00 55.94 ? 733 HOH A O 1 HETATM 8700 O O . HOH G 4 . ? 74.040 -4.374 4.379 1.00 24.98 ? 734 HOH A O 1 HETATM 8701 O O . HOH G 4 . ? 72.582 -16.269 5.239 1.00 32.27 ? 735 HOH A O 1 HETATM 8702 O O . HOH G 4 . ? 61.848 -0.422 -12.544 1.00 34.83 ? 736 HOH A O 1 HETATM 8703 O O . HOH G 4 . ? 47.171 -3.328 1.478 1.00 33.73 ? 737 HOH A O 1 HETATM 8704 O O . HOH G 4 . ? 65.988 5.672 -13.308 1.00 20.04 ? 738 HOH A O 1 HETATM 8705 O O . HOH G 4 . ? 45.980 -8.093 -10.432 1.00 19.04 ? 739 HOH A O 1 HETATM 8706 O O . HOH G 4 . ? 41.645 0.770 3.003 1.00 48.37 ? 740 HOH A O 1 HETATM 8707 O O . HOH G 4 . ? 78.823 -13.171 12.180 1.00 30.94 ? 741 HOH A O 1 HETATM 8708 O O . HOH G 4 . ? 67.600 -22.337 30.273 1.00 39.77 ? 742 HOH A O 1 HETATM 8709 O O . HOH G 4 . ? 40.069 1.925 26.050 1.00 52.01 ? 743 HOH A O 1 HETATM 8710 O O . HOH G 4 . ? 50.240 -14.114 -7.691 1.00 19.28 ? 744 HOH A O 1 HETATM 8711 O O . HOH G 4 . ? 52.004 -9.477 45.776 1.00 69.84 ? 745 HOH A O 1 HETATM 8712 O O . HOH G 4 . ? 36.774 -23.845 16.147 1.00 38.44 ? 746 HOH A O 1 HETATM 8713 O O . HOH G 4 . ? 60.587 -6.101 13.212 1.00 28.35 ? 747 HOH A O 1 HETATM 8714 O O . HOH G 4 . ? 58.578 -4.309 14.844 1.00 33.76 ? 748 HOH A O 1 HETATM 8715 O O . HOH G 4 . ? 56.488 -9.107 11.586 1.00 28.93 ? 749 HOH A O 1 HETATM 8716 O O . HOH G 4 . ? 27.672 -14.664 -13.323 1.00 17.15 ? 750 HOH A O 1 HETATM 8717 O O . HOH G 4 . ? 34.078 -20.036 -15.505 1.00 35.53 ? 751 HOH A O 1 HETATM 8718 O O . HOH G 4 . ? 49.802 -15.668 33.570 1.00 20.92 ? 752 HOH A O 1 HETATM 8719 O O . HOH G 4 . ? 66.163 13.487 -12.652 1.00 22.45 ? 753 HOH A O 1 HETATM 8720 O O . HOH G 4 . ? 63.612 10.058 -12.597 1.00 20.20 ? 754 HOH A O 1 HETATM 8721 O O . HOH G 4 . ? 43.454 -19.311 13.892 1.00 31.36 ? 755 HOH A O 1 HETATM 8722 O O . HOH G 4 . ? 52.805 18.483 -6.417 1.00 21.24 ? 756 HOH A O 1 HETATM 8723 O O . HOH G 4 . ? 75.880 -22.407 22.268 1.00 21.91 ? 757 HOH A O 1 HETATM 8724 O O . HOH G 4 . ? 34.261 -12.551 0.816 1.00 26.55 ? 758 HOH A O 1 HETATM 8725 O O . HOH G 4 . ? 75.091 -13.481 28.124 1.00 22.43 ? 759 HOH A O 1 HETATM 8726 O O . HOH G 4 . ? 50.976 -1.804 -8.878 1.00 62.07 ? 760 HOH A O 1 HETATM 8727 O O . HOH G 4 . ? 72.332 -11.767 22.285 1.00 24.13 ? 761 HOH A O 1 HETATM 8728 O O . HOH G 4 . ? 59.289 -9.074 13.401 1.00 21.67 ? 762 HOH A O 1 HETATM 8729 O O . HOH G 4 . ? 66.382 20.695 11.013 1.00 45.44 ? 763 HOH A O 1 HETATM 8730 O O . HOH G 4 . ? 56.665 9.138 33.389 1.00 56.03 ? 764 HOH A O 1 HETATM 8731 O O . HOH G 4 . ? 68.733 11.162 6.605 1.00 38.12 ? 765 HOH A O 1 HETATM 8732 O O . HOH G 4 . ? 44.713 -13.383 6.486 1.00 28.61 ? 766 HOH A O 1 HETATM 8733 O O . HOH G 4 . ? 73.236 -5.172 -3.770 1.00 33.34 ? 767 HOH A O 1 HETATM 8734 O O . HOH G 4 . ? 67.467 5.559 -2.643 1.00 34.33 ? 768 HOH A O 1 HETATM 8735 O O . HOH G 4 . ? 66.113 -12.240 4.797 1.00 40.26 ? 769 HOH A O 1 HETATM 8736 O O . HOH G 4 . ? 77.112 -3.122 -14.697 1.00 46.32 ? 770 HOH A O 1 HETATM 8737 O O . HOH G 4 . ? 45.760 -20.186 24.908 1.00 32.59 ? 771 HOH A O 1 HETATM 8738 O O . HOH G 4 . ? 60.968 -8.307 -5.670 1.00 44.02 ? 772 HOH A O 1 HETATM 8739 O O . HOH G 4 . ? 57.408 -8.526 22.478 1.00 55.57 ? 773 HOH A O 1 HETATM 8740 O O . HOH G 4 . ? 43.894 8.422 19.228 1.00 27.89 ? 774 HOH A O 1 HETATM 8741 O O . HOH G 4 . ? 71.034 -18.365 6.034 1.00 65.18 ? 775 HOH A O 1 HETATM 8742 O O . HOH G 4 . ? 40.131 1.185 -15.552 1.00 46.10 ? 776 HOH A O 1 HETATM 8743 O O . HOH G 4 . ? 40.631 -0.354 13.372 1.00 36.95 ? 777 HOH A O 1 HETATM 8744 O O . HOH G 4 . ? 33.872 0.721 -12.748 1.00 28.24 ? 778 HOH A O 1 HETATM 8745 O O . HOH G 4 . ? 62.191 15.762 -16.682 1.00 32.82 ? 779 HOH A O 1 HETATM 8746 O O . HOH G 4 . ? 59.416 1.897 -0.817 1.00 59.50 ? 780 HOH A O 1 HETATM 8747 O O . HOH G 4 . ? 30.407 -13.995 3.556 1.00 38.97 ? 781 HOH A O 1 HETATM 8748 O O . HOH G 4 . ? 41.721 -8.938 22.085 1.00 36.06 ? 782 HOH A O 1 HETATM 8749 O O . HOH G 4 . ? 54.669 -19.319 36.323 1.00 41.19 ? 783 HOH A O 1 HETATM 8750 O O . HOH G 4 . ? 38.734 -24.932 -2.484 1.00 210.42 ? 784 HOH A O 1 HETATM 8751 O O . HOH G 4 . ? 46.973 -1.155 -17.371 1.00 30.86 ? 785 HOH A O 1 HETATM 8752 O O . HOH G 4 . ? 60.543 -14.949 -22.081 1.00 57.45 ? 786 HOH A O 1 HETATM 8753 O O . HOH G 4 . ? 44.504 -4.438 -18.282 1.00 24.21 ? 787 HOH A O 1 HETATM 8754 O O . HOH G 4 . ? 56.750 9.567 -23.463 1.00 25.39 ? 788 HOH A O 1 HETATM 8755 O O . HOH G 4 . ? 33.692 -15.597 -4.066 1.00 25.80 ? 789 HOH A O 1 HETATM 8756 O O . HOH G 4 . ? 75.587 -20.331 -8.545 1.00 37.86 ? 790 HOH A O 1 HETATM 8757 O O . HOH G 4 . ? 38.740 -20.639 34.852 1.00 33.00 ? 791 HOH A O 1 HETATM 8758 O O . HOH G 4 . ? 70.158 -6.946 11.452 1.00 32.86 ? 792 HOH A O 1 HETATM 8759 O O . HOH G 4 . ? 31.946 -15.865 -11.501 1.00 27.25 ? 793 HOH A O 1 HETATM 8760 O O . HOH G 4 . ? 58.231 -24.136 19.333 1.00 51.95 ? 794 HOH A O 1 HETATM 8761 O O . HOH G 4 . ? 34.527 -9.691 0.570 1.00 31.73 ? 795 HOH A O 1 HETATM 8762 O O . HOH G 4 . ? 37.835 8.418 -0.437 1.00 44.42 ? 796 HOH A O 1 HETATM 8763 O O . HOH G 4 . ? 75.188 -15.974 5.673 1.00 55.21 ? 797 HOH A O 1 HETATM 8764 O O . HOH G 4 . ? 72.498 -6.555 2.859 1.00 56.86 ? 798 HOH A O 1 HETATM 8765 O O . HOH G 4 . ? 57.850 -18.253 15.078 1.00 37.00 ? 799 HOH A O 1 HETATM 8766 O O . HOH G 4 . ? 55.772 -4.209 -8.456 1.00 23.98 ? 800 HOH A O 1 HETATM 8767 O O . HOH G 4 . ? 62.905 17.003 -14.355 1.00 47.65 ? 801 HOH A O 1 HETATM 8768 O O . HOH G 4 . ? 44.090 1.602 -17.121 1.00 38.45 ? 802 HOH A O 1 HETATM 8769 O O . HOH G 4 . ? 45.529 -10.677 -11.189 1.00 33.78 ? 803 HOH A O 1 HETATM 8770 O O . HOH G 4 . ? 47.122 -12.126 34.239 1.00 24.19 ? 804 HOH A O 1 HETATM 8771 O O . HOH G 4 . ? 50.231 -4.623 39.347 1.00 28.37 ? 805 HOH A O 1 HETATM 8772 O O . HOH G 4 . ? 61.040 11.039 23.470 1.00 31.44 ? 806 HOH A O 1 HETATM 8773 O O . HOH G 4 . ? 42.783 -9.062 24.767 1.00 29.95 ? 807 HOH A O 1 HETATM 8774 O O . HOH G 4 . ? 30.581 -4.821 -7.168 1.00 29.61 ? 808 HOH A O 1 HETATM 8775 O O . HOH G 4 . ? 70.666 0.863 14.113 1.00 25.52 ? 809 HOH A O 1 HETATM 8776 O O . HOH G 4 . ? 53.513 -2.559 -7.552 1.00 34.49 ? 810 HOH A O 1 HETATM 8777 O O . HOH G 4 . ? 59.029 -11.183 15.244 1.00 21.90 ? 811 HOH A O 1 HETATM 8778 O O . HOH G 4 . ? 44.745 -30.086 -0.833 1.00 41.10 ? 812 HOH A O 1 HETATM 8779 O O . HOH G 4 . ? 24.721 -21.082 12.180 1.00 24.76 ? 813 HOH A O 1 HETATM 8780 O O . HOH G 4 . ? 47.838 13.362 4.434 1.00 14.22 ? 814 HOH A O 1 HETATM 8781 O O . HOH G 4 . ? 71.973 -16.410 -10.545 1.00 31.18 ? 815 HOH A O 1 HETATM 8782 O O . HOH G 4 . ? 74.338 -15.961 -15.372 1.00 30.92 ? 816 HOH A O 1 HETATM 8783 O O . HOH G 4 . ? 31.171 7.417 -10.713 1.00 23.51 ? 817 HOH A O 1 HETATM 8784 O O . HOH G 4 . ? 63.626 1.145 1.351 1.00 33.73 ? 818 HOH A O 1 HETATM 8785 O O . HOH H 4 . ? 7.201 16.989 -1.412 1.00 11.74 ? 701 HOH B O 1 HETATM 8786 O O . HOH H 4 . ? 27.443 -12.393 17.668 1.00 38.34 ? 702 HOH B O 1 HETATM 8787 O O . HOH H 4 . ? 2.615 13.318 16.922 1.00 22.65 ? 703 HOH B O 1 HETATM 8788 O O . HOH H 4 . ? 17.702 -16.164 41.393 1.00 55.78 ? 704 HOH B O 1 HETATM 8789 O O . HOH H 4 . ? -12.361 14.018 20.169 1.00 57.80 ? 705 HOH B O 1 HETATM 8790 O O . HOH H 4 . ? 4.525 11.697 -10.960 1.00 44.93 ? 706 HOH B O 1 HETATM 8791 O O . HOH H 4 . ? 10.917 1.365 23.007 1.00 28.90 ? 707 HOH B O 1 HETATM 8792 O O . HOH H 4 . ? 22.862 27.078 8.894 1.00 48.63 ? 708 HOH B O 1 HETATM 8793 O O . HOH H 4 . ? -5.173 -8.388 23.896 1.00 23.65 ? 709 HOH B O 1 HETATM 8794 O O . HOH H 4 . ? 5.283 20.045 -8.638 1.00 33.74 ? 710 HOH B O 1 HETATM 8795 O O . HOH H 4 . ? 21.333 -2.939 14.608 1.00 28.77 ? 711 HOH B O 1 HETATM 8796 O O . HOH H 4 . ? 9.916 11.725 -22.674 1.00 60.20 ? 712 HOH B O 1 HETATM 8797 O O . HOH H 4 . ? 31.609 13.681 29.131 1.00 54.78 ? 713 HOH B O 1 HETATM 8798 O O . HOH H 4 . ? 16.279 2.245 40.556 1.00 22.90 ? 714 HOH B O 1 HETATM 8799 O O . HOH H 4 . ? 5.290 3.092 21.533 1.00 37.32 ? 715 HOH B O 1 HETATM 8800 O O . HOH H 4 . ? 13.181 20.033 22.403 1.00 47.13 ? 716 HOH B O 1 HETATM 8801 O O . HOH H 4 . ? 19.350 0.714 35.955 1.00 37.71 ? 717 HOH B O 1 HETATM 8802 O O . HOH H 4 . ? 21.149 3.991 34.472 1.00 19.25 ? 718 HOH B O 1 HETATM 8803 O O . HOH H 4 . ? 25.033 -5.142 25.776 1.00 17.09 ? 719 HOH B O 1 HETATM 8804 O O . HOH H 4 . ? -3.616 16.669 -13.678 1.00 35.13 ? 720 HOH B O 1 HETATM 8805 O O . HOH H 4 . ? 28.790 3.042 -0.343 1.00 33.31 ? 721 HOH B O 1 HETATM 8806 O O . HOH H 4 . ? 30.838 5.569 27.395 1.00 29.83 ? 722 HOH B O 1 HETATM 8807 O O . HOH H 4 . ? 38.243 8.052 25.661 1.00 41.07 ? 723 HOH B O 1 HETATM 8808 O O . HOH H 4 . ? 15.156 23.494 25.368 1.00 65.31 ? 724 HOH B O 1 HETATM 8809 O O . HOH H 4 . ? 2.462 11.926 -13.011 1.00 37.13 ? 725 HOH B O 1 HETATM 8810 O O . HOH H 4 . ? 17.515 -8.215 22.909 1.00 56.46 ? 726 HOH B O 1 HETATM 8811 O O . HOH H 4 . ? 17.862 9.423 22.921 1.00 43.91 ? 727 HOH B O 1 HETATM 8812 O O . HOH H 4 . ? 11.292 11.985 13.022 1.00 22.54 ? 728 HOH B O 1 HETATM 8813 O O . HOH H 4 . ? 18.640 9.785 4.383 1.00 19.95 ? 729 HOH B O 1 HETATM 8814 O O . HOH H 4 . ? 6.565 7.747 -4.953 1.00 31.13 ? 730 HOH B O 1 HETATM 8815 O O . HOH H 4 . ? 1.372 29.809 23.705 1.00 26.51 ? 731 HOH B O 1 HETATM 8816 O O . HOH H 4 . ? 16.202 -8.034 -11.234 1.00 40.99 ? 732 HOH B O 1 HETATM 8817 O O . HOH H 4 . ? 9.361 15.956 20.013 1.00 52.64 ? 733 HOH B O 1 HETATM 8818 O O . HOH H 4 . ? 17.131 6.213 21.273 1.00 34.31 ? 734 HOH B O 1 HETATM 8819 O O . HOH H 4 . ? 16.420 3.633 8.208 1.00 37.01 ? 735 HOH B O 1 HETATM 8820 O O . HOH H 4 . ? -10.729 18.247 38.111 1.00 35.40 ? 736 HOH B O 1 HETATM 8821 O O . HOH H 4 . ? -16.703 15.195 37.235 1.00 44.92 ? 737 HOH B O 1 HETATM 8822 O O . HOH H 4 . ? 7.253 15.186 -10.017 1.00 12.64 ? 738 HOH B O 1 HETATM 8823 O O . HOH H 4 . ? 9.042 20.626 -9.895 1.00 22.83 ? 739 HOH B O 1 HETATM 8824 O O . HOH H 4 . ? 20.804 -9.199 36.357 1.00 10.81 ? 740 HOH B O 1 HETATM 8825 O O . HOH H 4 . ? 23.202 -13.163 36.582 1.00 14.71 ? 741 HOH B O 1 HETATM 8826 O O . HOH H 4 . ? 6.066 -9.950 25.904 1.00 23.31 ? 742 HOH B O 1 HETATM 8827 O O . HOH H 4 . ? 3.740 19.214 -11.676 1.00 56.23 ? 743 HOH B O 1 HETATM 8828 O O . HOH H 4 . ? 22.222 -4.283 -11.465 1.00 54.57 ? 744 HOH B O 1 HETATM 8829 O O . HOH H 4 . ? -0.707 -0.756 20.576 1.00 64.31 ? 745 HOH B O 1 HETATM 8830 O O . HOH H 4 . ? 8.053 7.709 -7.267 1.00 26.30 ? 746 HOH B O 1 HETATM 8831 O O . HOH H 4 . ? 9.447 20.541 36.240 1.00 36.12 ? 747 HOH B O 1 HETATM 8832 O O . HOH H 4 . ? 30.513 11.542 34.704 1.00 29.09 ? 748 HOH B O 1 HETATM 8833 O O . HOH H 4 . ? 0.596 30.700 15.200 1.00 41.71 ? 749 HOH B O 1 HETATM 8834 O O . HOH H 4 . ? 13.530 4.149 31.734 1.00 29.96 ? 750 HOH B O 1 HETATM 8835 O O . HOH H 4 . ? 1.688 -12.408 30.672 1.00 22.48 ? 751 HOH B O 1 HETATM 8836 O O . HOH H 4 . ? 23.364 23.719 -6.103 1.00 49.33 ? 752 HOH B O 1 HETATM 8837 O O . HOH H 4 . ? 25.672 3.365 3.168 1.00 58.02 ? 753 HOH B O 1 HETATM 8838 O O . HOH H 4 . ? 29.325 -4.164 -12.022 1.00 31.70 ? 754 HOH B O 1 HETATM 8839 O O . HOH H 4 . ? 5.902 0.223 21.713 1.00 30.86 ? 755 HOH B O 1 HETATM 8840 O O . HOH H 4 . ? 4.978 22.223 2.691 1.00 23.18 ? 756 HOH B O 1 HETATM 8841 O O . HOH H 4 . ? 26.306 -8.450 18.584 1.00 35.61 ? 757 HOH B O 1 HETATM 8842 O O . HOH H 4 . ? 14.855 17.491 23.286 1.00 45.44 ? 758 HOH B O 1 HETATM 8843 O O . HOH H 4 . ? 8.011 0.622 23.779 1.00 40.58 ? 759 HOH B O 1 HETATM 8844 O O . HOH H 4 . ? 22.201 -8.050 -5.869 1.00 46.62 ? 760 HOH B O 1 HETATM 8845 O O . HOH H 4 . ? 30.864 16.551 18.612 1.00 31.59 ? 761 HOH B O 1 HETATM 8846 O O . HOH H 4 . ? 21.510 -5.661 39.055 1.00 37.56 ? 762 HOH B O 1 HETATM 8847 O O . HOH H 4 . ? 29.919 11.489 0.998 1.00 34.15 ? 763 HOH B O 1 HETATM 8848 O O . HOH H 4 . ? 8.997 16.444 22.624 1.00 55.73 ? 764 HOH B O 1 HETATM 8849 O O . HOH H 4 . ? 18.830 8.134 28.964 1.00 48.97 ? 765 HOH B O 1 HETATM 8850 O O . HOH H 4 . ? 31.032 1.067 8.158 1.00 29.99 ? 766 HOH B O 1 HETATM 8851 O O . HOH H 4 . ? -8.696 28.771 29.265 1.00 20.42 ? 767 HOH B O 1 HETATM 8852 O O . HOH H 4 . ? 2.267 4.777 41.758 1.00 15.71 ? 768 HOH B O 1 HETATM 8853 O O . HOH H 4 . ? 5.713 5.748 45.786 1.00 17.88 ? 769 HOH B O 1 HETATM 8854 O O . HOH H 4 . ? 9.971 -17.824 29.805 1.00 23.18 ? 770 HOH B O 1 HETATM 8855 O O . HOH H 4 . ? 27.784 7.133 11.899 1.00 30.44 ? 771 HOH B O 1 HETATM 8856 O O . HOH H 4 . ? -5.545 12.855 0.902 1.00 20.66 ? 772 HOH B O 1 HETATM 8857 O O . HOH H 4 . ? -3.186 20.121 -12.244 1.00 35.89 ? 773 HOH B O 1 HETATM 8858 O O . HOH H 4 . ? -9.844 -1.623 20.508 1.00 26.76 ? 774 HOH B O 1 HETATM 8859 O O . HOH H 4 . ? -9.096 15.001 27.363 1.00 24.12 ? 775 HOH B O 1 HETATM 8860 O O . HOH H 4 . ? 25.540 -2.875 31.138 1.00 41.33 ? 776 HOH B O 1 HETATM 8861 O O . HOH H 4 . ? 10.202 -12.591 45.049 1.00 30.37 ? 777 HOH B O 1 HETATM 8862 O O . HOH H 4 . ? 3.510 8.457 33.909 1.00 33.83 ? 778 HOH B O 1 HETATM 8863 O O . HOH H 4 . ? 14.106 -5.389 24.447 1.00 26.44 ? 779 HOH B O 1 HETATM 8864 O O . HOH H 4 . ? 23.529 12.347 18.603 1.00 44.14 ? 780 HOH B O 1 HETATM 8865 O O . HOH H 4 . ? 11.878 -7.312 1.030 1.00 34.59 ? 781 HOH B O 1 HETATM 8866 O O . HOH H 4 . ? 2.898 23.839 2.014 1.00 35.90 ? 782 HOH B O 1 HETATM 8867 O O . HOH H 4 . ? 19.203 -10.829 -0.575 1.00 40.14 ? 783 HOH B O 1 HETATM 8868 O O . HOH H 4 . ? -8.780 -14.076 30.827 1.00 31.77 ? 784 HOH B O 1 HETATM 8869 O O . HOH H 4 . ? -8.357 9.185 28.615 1.00 39.98 ? 785 HOH B O 1 HETATM 8870 O O . HOH H 4 . ? -8.442 12.185 22.302 1.00 44.55 ? 786 HOH B O 1 HETATM 8871 O O . HOH H 4 . ? 5.748 -0.768 13.246 1.00 47.20 ? 787 HOH B O 1 HETATM 8872 O O . HOH H 4 . ? 23.630 29.254 10.263 1.00 37.09 ? 788 HOH B O 1 HETATM 8873 O O . HOH H 4 . ? -6.188 23.539 6.804 1.00 47.52 ? 789 HOH B O 1 HETATM 8874 O O . HOH H 4 . ? 26.948 4.861 -12.304 1.00 29.49 ? 790 HOH B O 1 HETATM 8875 O O . HOH H 4 . ? 21.665 -5.839 -9.276 1.00 80.69 ? 791 HOH B O 1 HETATM 8876 O O . HOH H 4 . ? 10.857 2.596 31.004 1.00 33.03 ? 792 HOH B O 1 HETATM 8877 O O . HOH H 4 . ? 10.180 19.818 8.718 1.00 39.02 ? 793 HOH B O 1 HETATM 8878 O O . HOH H 4 . ? -9.467 13.056 41.059 1.00 28.15 ? 794 HOH B O 1 HETATM 8879 O O . HOH H 4 . ? 21.288 -2.224 -16.830 1.00 40.31 ? 795 HOH B O 1 HETATM 8880 O O . HOH H 4 . ? 13.279 11.211 8.699 1.00 34.40 ? 796 HOH B O 1 HETATM 8881 O O . HOH H 4 . ? 11.146 12.253 10.404 1.00 43.29 ? 797 HOH B O 1 HETATM 8882 O O . HOH H 4 . ? 30.466 3.529 25.828 1.00 68.25 ? 798 HOH B O 1 HETATM 8883 O O . HOH H 4 . ? 33.606 13.694 -4.566 1.00 51.07 ? 799 HOH B O 1 HETATM 8884 O O . HOH H 4 . ? -3.646 4.753 2.952 1.00 26.34 ? 800 HOH B O 1 HETATM 8885 O O . HOH H 4 . ? -8.282 20.554 4.952 1.00 26.29 ? 801 HOH B O 1 HETATM 8886 O O . HOH H 4 . ? 23.780 -22.257 17.177 1.00 35.01 ? 802 HOH B O 1 HETATM 8887 O O . HOH H 4 . ? 23.912 1.135 -0.349 1.00 23.47 ? 803 HOH B O 1 HETATM 8888 O O . HOH H 4 . ? 2.019 -16.702 27.715 1.00 32.04 ? 804 HOH B O 1 HETATM 8889 O O . HOH H 4 . ? 10.432 19.943 2.379 1.00 33.47 ? 805 HOH B O 1 HETATM 8890 O O . HOH H 4 . ? 6.247 24.708 3.835 1.00 20.86 ? 806 HOH B O 1 HETATM 8891 O O . HOH H 4 . ? 23.490 8.503 9.646 1.00 32.01 ? 807 HOH B O 1 HETATM 8892 O O . HOH H 4 . ? 13.941 -9.011 46.998 1.00 36.54 ? 808 HOH B O 1 HETATM 8893 O O . HOH H 4 . ? 25.749 -23.672 20.783 1.00 35.79 ? 809 HOH B O 1 HETATM 8894 O O . HOH H 4 . ? 0.834 19.297 9.310 1.00 27.72 ? 810 HOH B O 1 HETATM 8895 O O . HOH H 4 . ? -3.466 7.910 -8.858 1.00 39.97 ? 811 HOH B O 1 HETATM 8896 O O . HOH H 4 . ? 5.507 -18.868 26.748 1.00 33.98 ? 812 HOH B O 1 #