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Table 1

Summary of approved interventional clinical trials for COVID-19 as of March 2020

Clinical trial no.LocationTitle and scope of clinical study
Clinical trials aimed at repairing damage to infected airways
NCT04273646Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

Title: Clinical Study of Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Severe COVID-19

Scope: use of infused umbilical cord mesenchymal stem cells to repair tissue damage in patients with pneumonia

NCT04288102Multiple sites in China

Title: Treatment with Mesenchymal Stem Cells for Severe Corona Virus Disease 2019 (COVID-19)

Scope: use of infused mesenchymal stem cells to repair tissue damage in patients with pneumonia

NCT04285190Tasly Pharmaceuticals Inc., China

Title: A Clinical Study to Investigate the Effect of T89 on Improving Oxygen Saturation and Clinical Symptoms in Patients with Coronavirus Disease 2019 (COVID-19)

Scope: use of T89 (Dantonic) in patients with COVID-19

NCT04287686The First Affiliated Hospital of Guangzhou Medical University

Title: Recombinant Human Angiotensin-Converting Enzyme 2 (rhACE2) as a Treatment for Patients with COVID-19

Scope: delivery of rhACE2 to regulate damage mediated by its downregulation by SARS-CoV-2 infection

NCT04275414Qilu Hospital of Shandong University Jinan, Shandong, China

Title: Bevacizumab in Severe or Critical Patients with COVID-19 Pneumonia

Scope: use of bevacizumab (Avastin) in patients with COVID-19

Clinical trials aimed at blocking SARS-CoV-2 infectivity
NCT04273763The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

Title: Evaluating the Efficacy and Safety of Bromhexine Hydrochloride Tablets Combined with Standard Treatment in Patients with Suspected and Mild Novel Coronavirus Pneumonia (COVID-19)

Scope: treatment of patients with COVID-19 with bromhexine hydrochloride, umifenovir hydrochloride, recombinant human interferon-α2b and favipiravir

NCT04280705USA

Title: Adaptive COVID-19 Treatment Trial

Scope: remdesivir treatment of patients with COVID-19

ChiCTR2000030039Affiliated Hospital of Xuzhou Medical University

Title: Clinical Study for Infusing Convalescent Plasma to Treat Patients with New Coronavirus Pneumonia (COVID-19)

Scope: infusion of polyclonal antibodies derived from immune plasma from convalescent patients with COVID-19

NCT04286503Multiple sites in China

Title: The Efficacy and Safety of Carrimycin Treatment in Patients with Novel Coronavirus Infectious Disease (COVID-19): A Multicenter, Randomized, Open Label Controlled Study

Scope: a multicentre, randomized (1:1), open-controlled (one of lopinavir/ritonavir tablets or umifenovir or chloroquine phosphate) study

ChiCTR2000030000Nanchang Ninth Hospital

Title: An Open, Controlled Clinical Trial for Evaluation of Ganovo Combined with Ritonavir and Integrated Traditional Chinese and Western Medicine in the Treatment of Novel Coronavirus Infection (COVID-19)

Scope: use of danoprevir (Ganovo), a macrocyclic peptidomimetic inhibitor of HCV protease, in patients with COVID-19

ChiCTR2000029740The First Hospital of Peking University

Title: Efficacy of Therapeutic Effects of Hydroxychloroquine in Novel Coronavirus Pneumonia (COVID-19) Patients. Randomized Open-Label Controlled Clinical Trial

Scope: use of hydroxychloroquine to test its antiviral and anti-inflammatory effects in patients with COVID-19

ChiCTR2000029559Renmin Hospital of Wuhan University

Title: Therapeutic Effect of Hydroxychloroquine on Novel Coronavirus Pneumonia (COVID-19)

Scope: use of hydroxychloroquine to test its antiviral and anti-inflammatory effects in patients with COVID-19

Clinical trials aimed at reducing inflammatory disease
NCT04273321Multiple sites in China

Title: Efficacy and Safety of Corticosteroids in COVID-19

Scope: multicentre study analysing the effect of methylprednisolone at a dosage of 1 mg kg−1 per day for 7 days in patients with COVID-19

NCT04280588First Affiliated Hospital of Fujian Medical University

Title: Fingolimod in COVID-19

Scope: use of fingolimod, a sphingosine 1-phosphate receptor modulator, in patients with COVID-19

NCT04273581First Affiliated Hospital of Wenzhou Medical University

Title: The Efficacy and Safety of Thalidomide Combined with Low-Dose Hormones in the Treatment of Severe COVID-19

Scope: testing the anti-inflammatory effects of thalidomide in combination with methylprednisolone in patients with COVID-19-induced pneumonia

NCT04288713Hudson Medical

Title: Eculizumab (Soliris) in Covid-19 Infected Patients

Scope: testing the efficacy of the complement C5 inhibitor eculizumab in patients with COVID-19

NCT04291053Tongji Hospital

Title: The Efficacy and Safety of Huaier in the Adjuvant Treatment of COVID-19

Scope: testing the anti-inflammatory effects of an extract of Trametes robiniophila Murr (Huaier) in patients with COVID-19

ChiCTR2000030388Jingzhou First People’s Hospital

Title: Efficacy and Safety of Xue-Bi-Jing Injection in the Treatment of Severe Cases of Novel Coronavirus Pneumonia (COVID-19)

Scope: analysing the anti-inflammatory effects of an extract from Salvia miltiorrhiza (Chinese red sage) on patients with COVID-19

ChiCTR2000029954Hubei Hospital of Traditional Chinese Medicine

Title: Efficacy and Safety of Honeysuckle Oral Liquid in the Treatment of Novel Coronavirus Pneumonia (COVID-19)

Scope: a multicentre, randomized, controlled, open clinical trial aimed at analysing the impact of honeysuckle oral liquid on boosting immunity against COVID-19

ChiCTR2000029855The First Affiliated Hospital of Medical College of Zhejiang University

Title: A Randomized, Open and Controlled Clinical Trial for Traditional Chinese Medicine in the Treatment of Novel Coronavirus Pneumonia (COVID-19)

Scope: no information available

Data from ClinicalTrials.gov149. COVID-19, coronavirus disease 2019; HCV, hepatitis C virus; rhACE2, recombinant human angiotensin-converting enzyme 2; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.