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PMC full text: | Published online 2020 Apr 28. doi: 10.1038/s41577-020-0311-8
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Clinical trial no. | Location | Title and scope of clinical study |
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Clinical trials aimed at repairing damage to infected airways | ||
NCT04273646 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China | Title: Clinical Study of Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Severe COVID-19 Scope: use of infused umbilical cord mesenchymal stem cells to repair tissue damage in patients with pneumonia |
NCT04288102 | Multiple sites in China | Title: Treatment with Mesenchymal Stem Cells for Severe Corona Virus Disease 2019 (COVID-19) Scope: use of infused mesenchymal stem cells to repair tissue damage in patients with pneumonia |
NCT04285190 | Tasly Pharmaceuticals Inc., China | Title: A Clinical Study to Investigate the Effect of T89 on Improving Oxygen Saturation and Clinical Symptoms in Patients with Coronavirus Disease 2019 (COVID-19) Scope: use of T89 (Dantonic) in patients with COVID-19 |
NCT04287686 | The First Affiliated Hospital of Guangzhou Medical University | Title: Recombinant Human Angiotensin-Converting Enzyme 2 (rhACE2) as a Treatment for Patients with COVID-19 Scope: delivery of rhACE2 to regulate damage mediated by its downregulation by SARS-CoV-2 infection |
NCT04275414 | Qilu Hospital of Shandong University Jinan, Shandong, China | Title: Bevacizumab in Severe or Critical Patients with COVID-19 Pneumonia Scope: use of bevacizumab (Avastin) in patients with COVID-19 |
Clinical trials aimed at blocking SARS-CoV-2 infectivity | ||
NCT04273763 | The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China | Title: Evaluating the Efficacy and Safety of Bromhexine Hydrochloride Tablets Combined with Standard Treatment in Patients with Suspected and Mild Novel Coronavirus Pneumonia (COVID-19) Scope: treatment of patients with COVID-19 with bromhexine hydrochloride, umifenovir hydrochloride, recombinant human interferon-α2b and favipiravir |
NCT04280705 | USA | Title: Adaptive COVID-19 Treatment Trial Scope: remdesivir treatment of patients with COVID-19 |
ChiCTR2000030039 | Affiliated Hospital of Xuzhou Medical University | Title: Clinical Study for Infusing Convalescent Plasma to Treat Patients with New Coronavirus Pneumonia (COVID-19) Scope: infusion of polyclonal antibodies derived from immune plasma from convalescent patients with COVID-19 |
NCT04286503 | Multiple sites in China | Title: The Efficacy and Safety of Carrimycin Treatment in Patients with Novel Coronavirus Infectious Disease (COVID-19): A Multicenter, Randomized, Open Label Controlled Study Scope: a multicentre, randomized (1:1), open-controlled (one of lopinavir/ritonavir tablets or umifenovir or chloroquine phosphate) study |
ChiCTR2000030000 | Nanchang Ninth Hospital | Title: An Open, Controlled Clinical Trial for Evaluation of Ganovo Combined with Ritonavir and Integrated Traditional Chinese and Western Medicine in the Treatment of Novel Coronavirus Infection (COVID-19) Scope: use of danoprevir (Ganovo), a macrocyclic peptidomimetic inhibitor of HCV protease, in patients with COVID-19 |
ChiCTR2000029740 | The First Hospital of Peking University | Title: Efficacy of Therapeutic Effects of Hydroxychloroquine in Novel Coronavirus Pneumonia (COVID-19) Patients. Randomized Open-Label Controlled Clinical Trial Scope: use of hydroxychloroquine to test its antiviral and anti-inflammatory effects in patients with COVID-19 |
ChiCTR2000029559 | Renmin Hospital of Wuhan University | Title: Therapeutic Effect of Hydroxychloroquine on Novel Coronavirus Pneumonia (COVID-19) Scope: use of hydroxychloroquine to test its antiviral and anti-inflammatory effects in patients with COVID-19 |
Clinical trials aimed at reducing inflammatory disease | ||
NCT04273321 | Multiple sites in China | Title: Efficacy and Safety of Corticosteroids in COVID-19 Scope: multicentre study analysing the effect of methylprednisolone at a dosage of 1mgkg−1 per day for 7 days in patients with COVID-19 |
NCT04280588 | First Affiliated Hospital of Fujian Medical University | Title: Fingolimod in COVID-19 Scope: use of fingolimod, a sphingosine 1-phosphate receptor modulator, in patients with COVID-19 |
NCT04273581 | First Affiliated Hospital of Wenzhou Medical University | Title: The Efficacy and Safety of Thalidomide Combined with Low-Dose Hormones in the Treatment of Severe COVID-19 Scope: testing the anti-inflammatory effects of thalidomide in combination with methylprednisolone in patients with COVID-19-induced pneumonia |
NCT04288713 | Hudson Medical | Title: Eculizumab (Soliris) in Covid-19 Infected Patients Scope: testing the efficacy of the complement C5 inhibitor eculizumab in patients with COVID-19 |
NCT04291053 | Tongji Hospital | Title: The Efficacy and Safety of Huaier in the Adjuvant Treatment of COVID-19 Scope: testing the anti-inflammatory effects of an extract of Trametes robiniophila Murr (Huaier) in patients with COVID-19 |
ChiCTR2000030388 | Jingzhou First People’s Hospital | Title: Efficacy and Safety of Xue-Bi-Jing Injection in the Treatment of Severe Cases of Novel Coronavirus Pneumonia (COVID-19) Scope: analysing the anti-inflammatory effects of an extract from Salvia miltiorrhiza (Chinese red sage) on patients with COVID-19 |
ChiCTR2000029954 | Hubei Hospital of Traditional Chinese Medicine | Title: Efficacy and Safety of Honeysuckle Oral Liquid in the Treatment of Novel Coronavirus Pneumonia (COVID-19) Scope: a multicentre, randomized, controlled, open clinical trial aimed at analysing the impact of honeysuckle oral liquid on boosting immunity against COVID-19 |
ChiCTR2000029855 | The First Affiliated Hospital of Medical College of Zhejiang University | Title: A Randomized, Open and Controlled Clinical Trial for Traditional Chinese Medicine in the Treatment of Novel Coronavirus Pneumonia (COVID-19) Scope: no information available |
Data from ClinicalTrials.gov149. COVID-19, coronavirus disease 2019; HCV, hepatitis C virus; rhACE2, recombinant human angiotensin-converting enzyme 2; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.