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| PMC full text: | Published online 2021 Feb 17. doi: 10.3389/fphar.2020.586993
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TABLE 1
Characteristics of some natural products against influenza virus.
| Influenza subtype | Plant/Solvent | Compounds | Effect | Ref | ||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| H1N1/PR8 | Salvia plebeia R.Br/methanol | 6-Hydroxyluteolin 7-O-β-d-glucoside, Nepitrin (1) and homoplantaginin | NA inhibitor | Bang et al. (2018) | ||||||||||||||||||||||
| H1N1/PR8 | Matteuccia struthiopteris (L.) Tod. (Onoclea struthiopteris Roth)/ethanol | Matteflavoside G (2) | NA inhibitor | Li et al. (2015) | ||||||||||||||||||||||
| H1N1/PR8 | Salvia plebeian R.Br/methanol | Hispidulin (3), Nepetin (4), Methyl ester (5) | NA inhibitor | Bang et al. (2016) | ||||||||||||||||||||||
| H5N1 | Capparis sinaica Veill. (Capparis spinosa var. aegyptia (Lam.) Boiss.) /methanol | Quercetin (6), Isoquercetin (7), Rutin (8) | NA inhibitor | Ibrahim et al. (2013) | ||||||||||||||||||||||
| H1N1/PR8 H1N1/NWS H7N1 | Humulus lupulus L./hydroalcoholic | Quercetin (6), Rutin (8) | Interference with redox-sensitive pathways | Di Sotto et al. (2018) | ||||||||||||||||||||||
| H1N1/PR8 | Rapanea melanophloeos (L.) Mez (Myrsine melanophloeos (L.) R.Br. ex Sweet) and Pittosporum viridiflorum Sims /methanol | Crude | HA inhibitor | Mehrbod et al. (2018) | ||||||||||||||||||||||
| H1N1/PR8 | Rapanea melanophloeos (L.) Mez (Myrsine melanophloeos (L.) R.Br. ex Sweet)/methanol | Quercetin-3-o-α-l-rhamnopyranoside (9) | Blocking the virus receptor | Mehrbod et al. (2018) | ||||||||||||||||||||||
| H1N1/PR8 | Rapanea melanophloeos (L.) Mez (Myrsine melanophloeos (L.) R.Br. ex Sweet)/methanol | Quercetin-3-o-α-l-rhamnopyranoside (9) | Interaction with M2, NA and RhoA | Mehrbod et al., (2019) | ||||||||||||||||||||||
| H1N1/PR8, H3N2 | green tea/ND | Epigallocatechin-3-gallate (10) | NA inhibitor | Kim et al. (2013) | ||||||||||||||||||||||
| H1N1 | White mulberry root/methanol | Sanggenon G (11), Sanggenol A (12) | NA inhibitor | Grienke et al. (2018) | ||||||||||||||||||||||
| H1N1, H9N2 | Cleistocalyx operculatus (Roxb.) Merr. & L.M.Perry (Syzygium nervosum A.Cunn. ex DC.) /methanol | (E)-4, 2′, 4′-trihydroxy6′-methoxy-3′,5′-dimethylchalcone (13), 2.2′,4′-trihydroxy-6′- methoxy-3′,5′-dimethylchalcone (14) | NA inhibitor | Dao et al. (2010) | ||||||||||||||||||||||
| H1N1, H9N2, H1N1 (H274Y4Y) | Glycyrrhiza inflata Batalin/acetone | Echinantin (15), Isoliquiritigenin (16) | NA inhibitor | Dao et al. (2011) | ||||||||||||||||||||||
| H1N1/PR8 H3N2 | Ginkgo biloba L./ND | Ginkgetin (17), Hinokiflavone (18), 4′-O-methylochnaflavone (19) | NA inhibitor | Miki et al. (2007) | ||||||||||||||||||||||
| H1N1 | Glycyrrhiza uralensis Fisch. ex DC./methanol | Isoliquiritigenin, glycyrol (20) | NA inhibitor | Ryu et al. (2010) | ||||||||||||||||||||||
| H1N1 | Ferula assa-foetida L. (Ferula foetida (Bunge) Regel)/methanol | Methyl galbanate (21) | ND | Lee et al. (2009) | ||||||||||||||||||||||
| H1N1, H9N2 | Polygala karensium Kurz/ethyl acetate | 1,7-Dihydroxyxanthone, 1,7-dihydroxy-4-methoxyxanthone, 1,3,7-trihydroxyxanthone, 1.2,3,5-tetrahydroxyxanthone (22–26) | NA inhibitors | Dao et al. (2012) | ||||||||||||||||||||||
| H1N1/PR8 | Salvia plebeian R.Br/methanol | Rosmarinic acid methyl ester (27) | NA inhibitor | Bang et al. (2016) | ||||||||||||||||||||||
| H1N1 | Phellinus linteus/ethyl acetate | Inotilone (28), 4-(3, 4-dihydroxyphenyl)-3-buten-2-one (29) | NA inhibitor | Hwang et al. (2014) | ||||||||||||||||||||||
| H1N1,H5N2, H3N2 | Embelia ribes Burm.f./ethyl acetate | Embeline (30) | HA inhibitor | Hossan et al. (2018) | ||||||||||||||||||||||
| H1N1 | Alpinia katsumadai K.Schum. (Alpinia hainanensis K.Schum.) /ethanol | Katsumadain A (31) | NA inhibitor | Grienke et al. (2010) | ||||||||||||||||||||||
| H1N1, H3N2, flu B | Euphorbia humifusa Willd./ND | 1,3,4,6-tetra-O-galloyl-b-d-glucopyranoside (32) | Inhibits the nuclear export of NP | Chang et al. (2016) | ||||||||||||||||||||||
| H1N1 | Cynanchum paniculatum (Bunge) Kitag. ex H.Hara (Vincetoxicum mukdenense Kitag.)/ethyl acetate | Cynanversicoside A (33) | Suppressing NF-κB and MAPKs activation | Wei et al. (2017) | ||||||||||||||||||||||
| H5N1 | Sonchus oleraceus L. and Armeria maritima (Mill.) Willd./Methanol | Chlorogenic acid derivatives | NA inhibitor | Karar et al. (2016) | ||||||||||||||||||||||
| H1N1, H9N2, H3N2 | Forsythia suspense (Thunb.) Vahl /Methanol | Forsythoside A (34) | Reduction in the M1 protein | Law et al. (2017) | ||||||||||||||||||||||
| H1N1 | Gardenia jasminoides J.Ellis/methanol | Iridoids glycosides and phenylpropanoid derivatives | ND | Yang et al. (2012) | ||||||||||||||||||||||
NA, neuraminidase; ND, not-determined; NP, nuclear protein; HA, hemagglutinin; M1, matrix protein; RhoA, Ras homolog family member A; MAPKs, Mitogen-activated protein kinases.