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Regulation of ligands for the NKG2D activating receptor.

Author information

Affiliations

  • 1. Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, California 94720-3200, USA.
      Authors
    • Raulet DH 1
    (1 author)

ORCIDs linked to this article

Annual Review of Immunology, 03 Jan 2013, 31:413-441
https://doi.org/10.1146/annurev-immunol-032712-095951 PMID: 23298206 PMCID: PMC4244079

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Abstract 

NKG2D is an activating receptor expressed by all NK cells and subsets of T cells. It serves as a major recognition receptor for detection and elimination of transformed and infected cells and participates in the genesis of several inflammatory diseases. The ligands for NKG2D are self-proteins that are induced by pathways that are active in certain pathophysiological states. NKG2D ligands are regulated transcriptionally, at the level of mRNA and protein stability, and by cleavage from the cell surface. In some cases, ligand induction can be attributed to pathways that are activated specifically in cancer cells or infected cells. We review the numerous pathways that have been implicated in the regulation of NKG2D ligands, discuss the pathologic states in which those pathways are likely to act, and attempt to synthesize the findings into general schemes of NKG2D ligand regulation in NK cell responses to cancer and infection.

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Read article at publisher's site: https://doi.org/10.1146/annurev-immunol-032712-095951

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Funding 

Funders who supported this work.

NCI NIH HHS (2)

NIAID NIH HHS (2)