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Table 3

Studies supporting the role of deep gray matter substrates in multiple sclerosis fatigue.

Authors (Year)TechniqueScalesPopulationOutcome
Niepel et al., 2006MRIFSS52 RRMSCorrelation of FSS with abnormal T1 relaxation time within the thalami
Inglese et al., 2007MRIMFI22 MS (11RRMS, 11 PPMS)Correlation of MFI with the cerebral blood volume and flow in the thalamus and basal ganglia
Téllez et al., 20081H-MRSMFIS, FSS41 RRMSCorrelation of physical domain of MFIS with abnormal NAA/cr ratio within the lentiform nucleus

FSS, Fatigue Severity Scale; 1H-MRS, proton magnetic reasoning imaging; MFI, Multidimensional Fatigue Inventory; MFIS, Modified Fatigue Impact Scale; NAA/cr, N-acetyl aspartate to creatinine ratio; RRMS, relapsing remitting multiple sclerosis; PPMS, primary progressive MS.