Europe PMC
Nothing Special   »   [go: up one dir, main page]

Europe PMC requires Javascript to function effectively.

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page.

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma.

Show less

Author information

Affiliations

  • 1. Université Strasbourg, INSERM U1109-MN3T, The Microenvironmental Niche in Tumorigenesis and Targeted Therapy, and The Tumor Microenvironment Laboratory, Hopital Civil, Institut d'Hématologie et d'Immunologie, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France.
      Authors
    • Spenlé C 1
    • Loustau T 1
    • Murdamoothoo D 1
    • Erne W 1
    • Cremel G 1
    • Randrianarisoa V 1
    • Orend G 1
    (7 authors)
  • 2. Université Côte d'Azur, CNRS, INSERM, iBV, Nice, France.
      Authors
    • Beghelli-de la Forest Divonne S 2
    • Rekima S 2
    • Schaub S 2
    • Sudaka A 2
    • Van Obberghen-Schilling E 2
    (5 authors)
  • 3. Institut de Biologie Moléculaire et Cellulaire, CNRS, UPR3572 Immunologie, Immunopathologie et Chimie Thérapeutique, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France.
      Authors
    • Veber R 3
    • Camara A 3
    • Dumortier H 3
    • Mueller CG 3
    (4 authors)
  • 4. Université Côte d'Azur, CNRS, IPMC, Valbonne-Sophia Antipolis, France.
      Authors
    • Petti L 4
    • Bourdely P 4
    • Nouhen K 4
    • Anjuère F 4
    (4 authors)
  • 5. Colzyx AB, Lund, Sweden.
      Authors
    • Mörgelin M 5
    (1 author)
    • Show all (11)

ORCIDs linked to this article

Show all (17)

Cancer Immunology Research, 14 Jul 2020, 8(9):1122-1138
https://doi.org/10.1158/2326-6066.cir-20-0074 PMID: 32665262 

Abstract 

Inherent immune suppression represents a major challenge in the treatment of human cancer. The extracellular matrix molecule tenascin-C promotes cancer by multiple mechanisms, yet the roles of tenascin-C in tumor immunity are incompletely understood. Using a 4NQO-induced oral squamous cell carcinoma (OSCC) model with abundant and absent tenascin-C, we demonstrated that tenascin-C enforced an immune-suppressive lymphoid stroma via CCL21/CCR7 signaling, leading to increased metastatic tumors. Through TLR4, tenascin-C increased expression of CCR7 in CD11c+ myeloid cells. By inducing CCL21 in lymphatic endothelial cells via integrin α9β1 and binding to CCL21, tenascin-C immobilized CD11c+ cells in the stroma. Inversion of the lymph node-to-tumor CCL21 gradient, recruitment of T regulatory cells, high expression of anti-inflammatory cytokines, and matrisomal components were hallmarks of the tenascin-C-instructed lymphoid stroma. Ablation of tenascin-C or CCR7 blockade inhibited the lymphoid immune-suppressive stromal properties, reducing tumor growth, progression, and metastasis. Thus, targeting CCR7 could be relevant in human head and neck tumors, as high tenascin-C expression and an immune-suppressive stroma correlate to poor patient survival.

Full text links 

Read article at publisher's site: https://doi.org/10.1158/2326-6066.cir-20-0074

Read article for free, from open access legal sources, via Unpaywall: https://hal.archives-ouvertes.fr/hal-02902040/file/Spenle%2C%20Cancer%20Immunology%20Res%2C%202020.pdfUnpaywall

HAL Open Archive
https://hal.archives-ouvertes.fr/hal-02902040

Citations & impact 

Impact metrics

38
Citations
Jump to Citations
10
Data citations
Jump to Data

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/87067588
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/87067588

Article citations

Go to all (38) article citations

Data 

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

Funding 

Funders who supported this work.

ARC (2)

Cancéropôle PACA and LABEX SIGNALIFE (1)

Deutsche Forschungsgemeinschaft (2)

Ministry of Science, Research and Art Baden-Württemberg (2)