Objective: Hispanic/Latine college students are increasingly at high risk to experience self-injurious thoughts and behaviors (SITBs). This brief report examined SITB prevalence rates among a national sample of Hispanic/Latine college students, with specificity to sub-group characteristics. Participants: Hispanic college students across 139 institutions from a national survey of college student mental health (Healthy Minds Study) in the US (N = 12,499). Methods: The present cross-sectional, secondary data analysis examines prevalence rates of SITBs by sub-group characteristics (nativity, heritage, documentation status, other socio-demographics) using chi-square analyses and standardized residuals. Results: Younger (18-24 years old; p < 0.001), US-Born (p < 0.001), gender expansive/transgender (p < 0.001), and financially stressed (p < 0.001) Hispanic/Latine college students report higher rates of SITBs overall. Conclusion: Findings underscore the importance of examining overlapping and intersecting identities that can inform prevention efforts for the Hispanic/Latine student population in the US. Policy and institution-level recommendations for resource allocation and tailored prevention strategies are discussed.