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Global quantification and distribution of antibiotic resistance genes in oceans and seas: Anthropogenic impacts and regional variability.

Author information

Affiliations

  • 1. National Center for Water Safety (CeNSia), Istituto Superiore di Sanità, Rome, Italy.
      Authors
    • Bonanno Ferraro G 1
    • Franco A 1
    • Iaconelli M 1
    • Mancini P 1
    • Veneri C 1
    • Briancesco R 1
    • Coccia AM 1
    • Muratore A 1
    • Ferrara F 1
    • Lucentini L 1
    • La Rosa G 1
    (11 authors)
  • 2. Departments of Infectious Disease, Istituto Superiore di Sanità, Rome, Italy.
      Authors
    • Brandtner D 2
    (1 author)
  • 3. Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.
      Authors
    • Suffredini E 3
    (1 author)
  • 4. Office of the Director General - Istituto Superiore di Sanità, Rome, Italy.
      Authors
    • Piccioli A 4
    (1 author)

ORCIDs linked to this article

The Science of the Total Environment, 10 Oct 2024, 955:176765
https://doi.org/10.1016/j.scitotenv.2024.176765 PMID: 39395504 

Abstract 

The global spread of antibiotic resistance genes (ARGs) in the marine environment poses a significant threat to public health and natural ecosystems. This study quantified and analysed the distribution and co-occurrence patterns of ARGs in a wide range of oceans and high seas, including the Atlantic, Arctic and Indian Ocean, the Mediterranean Sea and the Persian Gulf. Focusing on beta-lactamases (blaOXA-48, blaCTX-M-1 group, and blaTEM), sulfonamides (sul1) and tetracycline (tetA), our results showed that sul1 was ubiquitous, indicating widespread dissemination. Notably, the Mediterranean Sea exhibited higher levels of multiple ARGs in single samples, suggesting significant anthropogenic impact. Interestingly, the Arctic Ocean, particularly around the Svalbard Islands, also showed the presence of multiple ARGs, highlighting the pervasive occurrence of antibiotic resistance in remote areas. We employed two clustering approaches to explore ARG patterns, primarily focusing on identifying geographic trends and differences in ARG abundance. Additionally, we investigated potential sources of contamination, including proximity to wastewater treatment plants, ports, marine traffic, and currents. These findings clearly demonstrate that antibiotic resistance gene contamination is widespread across diverse marine environments, with significant regional variations. This underscores the urgent need for tailored intervention strategies and global collaboration to mitigate the spread of ARGs and manage their complex dynamics in marine ecosystems.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/j.scitotenv.2024.176765

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