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A multidisciplinary view of flash irradiation.

Author information

Affiliations

  • 1. Institut Curie, Hospital Division, centre de protonthérapie d'Orsay, université Paris-Saclay, université PSL, centre universitaire, 91948 Orsay cedex, France.
      Authors
    • Gesualdi F 1
    (1 author)
  • 2. Institut Curie, Hospital Division, centre de protonthérapie d'Orsay, université Paris-Saclay, université PSL, centre universitaire, 91948 Orsay cedex, France; Institut Curie, université PSL, université Paris-Saclay, Inserm Lito U1288, centre universitaire, 91898 Orsay, France.
      Authors
    • de Marzi L 2
    (1 author)
  • 3. Institut Curie, Research Division, Inserm U 1021-CNRS UMR 3347, université Paris-Saclay, université PSL, centre universitaire, 91401 Orsay cedex, France.
      Authors
    • Dutreix M 3
    • Favaudon V 3
    • Fouillade C 3
    • Heinrich S 3
    (4 authors)

ORCIDs linked to this article

Cancer Radiotherapie : Journal de la Societe Francaise de Radiotherapie Oncologique, 28 Sep 2024, 28(5):453-462
https://doi.org/10.1016/j.canrad.2024.07.003 PMID: 39343695 

Review

Abstract 

The delivery of ultra-high dose rates of radiation, called flash irradiation or flash-RT, has emerged as a new modality of radiotherapy shaking up the paradigm of proportionality of effect and dose whatever the method of delivery of the radiation. The hallmark of flash-RT is healthy tissue sparing from the side effects of radiation without decrease of the antitumor efficiency in animal models. In this review we will define its specificities, the molecular mechanisms underlying the flash effect and the ongoing developments to bring this new modality to patient treatment.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/j.canrad.2024.07.003

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