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Micro-C Analysis Workflow Using Pairtools and Juicer.

Author information

Affiliations

  • 1. Laboratory of Genome Structure and Function, Institute for Quantitative Biosciences, University of Tokyo, Bunkyo City, Tokyo, Japan.
      Authors
    • Sakata T 1
    (1 author)

Methods in Molecular Biology (Clifton, N.J.), 01 Jan 2025, 2856:63-70
https://doi.org/10.1007/978-1-0716-4136-1_4 PMID: 39283446 

Abstract 

Three-dimensional (3D) chromosome structures are closely related to various chromosomal functions, and deep analysis of the structures is crucial for the elucidation of the functions. In recent years, chromosome conformation capture (3C) techniques combined with next-generation sequencing analysis have been developed to comprehensively reveal 3D chromosome structures. Micro-C is one such method that can detect the structures at nucleosome resolution. In this chapter, I provide a basic method for Micro-C analysis. I present and discuss a series of data analyses ranging from mapping to basic downstream analyses, including loop detection.

Full text links 

Read article at publisher's site: https://doi.org/10.1007/978-1-0716-4136-1_4

References 

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