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Anti-obesity medications in the management of heart failure with preserved ejection fraction: available evidence and next STEPS.

Author information

Affiliations

  • 1. Division of Cardiology, Department of Internal Medicine, Duke University Medical Center, Durham, NC, USA.
      Authors
    • Harrington J 1
    (1 author)

ORCIDs linked to this article

Heart Failure Reviews, 04 Jul 2024, 29(5):939-944
https://doi.org/10.1007/s10741-024-10410-0 PMID: 38965119 

Review

Abstract 

Obesity is associated with an increased risk of incident heart failure with preserved ejection fraction (HFpEF) and, among patients with existing heart failure, is associated with worse quality of life, higher symptom burden, and more HF hospitalizations. Anti-obesity medication (AOM) semaglutide has been shown to be efficacious at both causing intentional weight loss and improving HF symptom burden, with some evidence to suggest that HF clinical events may also be reduced. Additional ongoing trials of AOM in patients with cardiovascular disease, including HFpEF, will further improve insight into the potential role of managing obesity to improve HF status among patients with HFpEF and obesity.

Full text links 

Read article at publisher's site: https://doi.org/10.1007/s10741-024-10410-0

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