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Abstract 


In this issue of Structure, Sievers et al.1 gain important insights into the human tRNA guanine transglycosylase QTRT1/2. The study presents a cryo-EM reconstruction of the inhibited human heterodimer in complex with human tRNAAsp, which represents the first snapshot of a eukaryotic TGT in complex with its full-length tRNA substrate.

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    Funding 


    Funders who supported this work.

    European Research Council (1)

    Horizon 2020

      Horizon 2020 Framework Programme