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Uncovering the Potential Mechanisms and Effects of Hyperuricemia and its Associated Diseases on Male Reproduction.

Author information

Affiliations

  • 1. Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
      Authors
    • Liu YF 1
    • Wang HH 1
    • Geng YH 1
    (3 authors)
  • 2. Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
      Authors
    • Han L 2
    • Tu SH 2
    (2 authors)
  • 3. The Reproduction Center, Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou, China.
      Authors
    • Chen JS 3
    (1 author)
  • 4. The Reproduction Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
      Authors
    • Wen CY 4
    (1 author)

ORCIDs linked to this article

Reproductive Sciences (Thousand Oaks, Calif.), 20 Feb 2024, 31(8):2184-2198
https://doi.org/10.1007/s43032-024-01453-7 PMID: 38379071 

Review

Abstract 

Male fertility and metabolic disorders, including obesity and diabetes, are closely connected. Since hyperuricemia and metabolic syndrome are strongly related, male fertility and hyperuricemia may, to some degree, be associated. According to recent studies, hyperuricemia imposes various effects on sex hormones, semen quality, and male erectile dysfunction. Some researchers claim that uric acid worsens male semen and raises the risk of erectile dysfunction (ED), while others state that it safeguards both penile erection and male semen. Additionally, it has been shown that gout and metabolic syndrome also raise the risk of ED. To clarify this controversy, the influence and potential mechanisms of hyperuricemia on ED, semen quality, sex hormone levels, and the effects of hyperuricemia-related disorders on ED will be comprehensively summarized.

Full text links 

Read article at publisher's site: https://doi.org/10.1007/s43032-024-01453-7

References 

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Funding 

Funders who supported this work.

National Natural Science Foundation of China (1)