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Non-coding RNAs in disease: from mechanisms to therapeutics.

Author information

Affiliations

  • 1. Translational Molecular Pathology Department, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
      Authors
    • Nemeth K 1
    • Bayraktar R 1
    • Calin GA 1
    (3 authors)
  • 2. Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
      Authors
    • Ferracin M 2
    (1 author)

ORCIDs linked to this article

Nature reviews. Genetics, 15 Nov 2023, 25(3):211-232
https://doi.org/10.1038/s41576-023-00662-1 PMID: 37968332 

Review

Abstract 

Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are not translated into proteins. Since their discovery, ncRNAs have emerged as important regulators of multiple biological functions across a range of cell types and tissues, and their dysregulation has been implicated in disease. Notably, much research has focused on the link between microRNAs (miRNAs) and human cancers, although other ncRNAs, such as long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), are also emerging as relevant contributors to human disease. In this Review, we summarize our current understanding of the roles of miRNAs, lncRNAs and circRNAs in cancer and other major human diseases, notably cardiovascular, neurological and infectious diseases. Further, we discuss the potential use of ncRNAs as biomarkers of disease and as therapeutic targets.

Full text links 

Read article at publisher's site: https://doi.org/10.1038/s41576-023-00662-1

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