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Gastrointestinal signet ring cell malignancy: current advancement and future prospects.

Author information

Affiliations

  • 1. Department of Oncology, Guangdong Sanjiu Brain Hospital, 578 Shatai Road, Baiyun District, Guangzhou City, Guangdong Province, China.
      Authors
    • Hong W 1
    • Hu Q 1
    (2 authors)
  • 2. The Medical Department, Jiangsu Simcere Diagnostics Co., Ltd., Nanjing Simcere Medical Laboratory Science Co., Ltd., The State Key Lab of Translational Medicine and Innovative Drug Development, Jiangsu Simcere Diagnostics Co., Ltd., Nanjing, China.
      Authors
    • Tan Y 2
    • Duan Q 2
    • Zhang Q 2
    • Chen D 2
    • Qi C 2
    (5 authors)
  • 3. Department of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Rd., Hangzhou, China.
      Authors
    • Wang D 3
    (1 author)

Investigational new Drugs, 21 Oct 2023, 41(6):861-869
https://doi.org/10.1007/s10637-023-01403-1 PMID: 37864727 

Review

Abstract 

Globally, gastrointestinal cancer is the most widespread neoplastic disease and the primary contributor to cancer-associated fatalities. Gastrointestinal signet ring cell carcinoma (SRCC) exhibits unique distinguishing features in several aspects when compared to adenocarcinomas (ACs). The scarcity of signet ring cell carcinoma has resulted in a heightened significance of related clinical and molecular investigations. However, a comprehensive and systematic review of the clinical, molecular, therapeutic, and research aspects of this disease is currently absent. This review provides an overview of the latest developments in our understanding of the clinical and molecular features of gastrointestinal signet ring cell carcinoma (SRCC). Additionally, we have compiled a list of potential therapeutic targets or biomarkers, as well as an examination of the current treatment options and the possible mechanisms of formation.

Full text links 

Read article at publisher's site: https://doi.org/10.1007/s10637-023-01403-1

References 

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