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A complex systems approach to aging biology.

Author information

Affiliations

  • 1. PRIMUS Research Group, Department of Family Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada.
      Authors
    • Cohen AA 1, 3
    (1 author)
  • 2. Intramural Research Program of the National Institute on Aging, Baltimore, MD, USA.
      Authors
    • Ferrucci L 2
    (1 author)
  • 3. Research Center on Aging and Research Center of Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada.
      Authors
    • Cohen AA 1, 3
    • Fülöp T 3
    (2 authors)
  • 4. Department of Biology, University of Sherbrooke, Sherbrooke, Quebec, Canada.
      Authors
    • Gravel D 4
    (1 author)
  • 5. Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, San Diego, CA, USA.
      Authors
    • Hao N 5
    (1 author)
    • Show all (12)

ORCIDs linked to this article

Show all (8)

Nature Aging, 20 Jul 2022, 2(7):580-591
https://doi.org/10.1038/s43587-022-00252-6 PMID: 37117782 

Review

Abstract 

Having made substantial progress understanding molecules, cells, genes and pathways, aging biology research is now moving toward integration of these parts, attempting to understand how their joint dynamics may contribute to aging. Such a shift of perspective requires the adoption of a formal complex systems framework, a transition being facilitated by large-scale data collection and new analytical tools. Here, we provide a theoretical framework to orient researchers around key concepts for this transition, notably emergence, interaction networks and resilience. Drawing on evolutionary theory, network theory and principles of homeostasis, we propose that organismal function is accomplished by the integration of regulatory mechanisms at multiple hierarchical scales, and that the disruption of this ensemble causes the phenotypic and functional manifestations of aging. We present key examples at scales ranging from sub-organismal biology to clinical geriatrics, outlining how this approach can potentially enrich our understanding of aging.

Full text links 

Read article at publisher's site: https://doi.org/10.1038/s43587-022-00252-6

Read article for free, from open access legal sources, via Unpaywall: https://www.nature.com/articles/s43587-022-00252-6.pdfUnpaywall

References 

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Citations & impact 

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Funding 

Funders who supported this work.

NIA NIH HHS (2)

NIGMS NIH HHS (1)