Europe PMC Pseudomonas-tailed lytic phages: genome mechanical analysis and putative correlation with virion morphogenesis yield.">Pseudomonas-tailed lytic phages: genome mechanical analysis and putative correlation with virion morphogenesis yield.">
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Pseudomonas-tailed lytic phages: genome mechanical analysis and putative correlation with virion morphogenesis yield.

Author information

Affiliations

  • 1. PhageLab - Laboratory of Biofilms & Bacteriophages, University of Sorocaba, Sorocaba/SP, 18023-000, Brazil.
      Authors
    • Balcão VM 1, 4
    • Vila MM 1
    (2 authors)
  • 2. Department of Biophysics & Biophysical Chemistry, Johns Hopkins University, Baltimore, MD, USA.
      Authors
    • Basu A 2
    • Cieza B 2
    • Ha T 2
    (3 authors)
  • 3. Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, 05508-000, Brazil.
      Authors
    • Rossi FN 3
    • Setubal JC 3
    • da Silva AM 3
    (3 authors)
  • 4. Department of Biology & CESAM, University of Aveiro, Campus Universitário de Santiago, Aveiro, P-3810-193, Portugal.
      Authors
    • Balcão VM 1, 4
    • Pereira C 4
    (2 authors)

ORCIDs linked to this article

Show all (8)

Future Microbiology, 26 Jul 2022, 17:1009-1026
https://doi.org/10.2217/fmb-2021-0293 PMID: 35880493 

Abstract 

Aim: To unveil a putative correlation between phage genome flexibility and virion morphogenesis yield. Materials & methods: A deeper analysis of the mechanical properties of three Pseudomonas aeruginosa lytic phage genomes was undertaken, together with full genome cyclizability calculations. Results & conclusion: A putative correlation was established among phage genome flexibility, eclipse timeframe and virion particle morphogenesis yield, with a more flexible phage genome leading to a higher burst size and a more rigid phage genome leading to lower burst sizes. The results obtained are highly relevant to understand the influence of the phage genome plasticity on the virion morphogenesis yield inside the infected bacterial host cells and assumes particular relevance in the actual context of bacterial resistance to antibiotics.

Full text links 

Read article at publisher's site: https://doi.org/10.2217/fmb-2021-0293

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Funding 

Funders who supported this work.

Conselho Nacional de Desenvolvimento Científico e Tecnológico (1)

Fundação de Amparo à Pesquisa do Estado de São Paulo (1)

Fundação para a Ciência e a Tecnologia (1)