Inflammation and Parkinson's disease pathogenesis.

Abstract

Inflammation is a neuropathological feature of parkinsonian brains and also in experimental models of the disease. It is believed that activated glial cells, which compose the majority of this inflammatory response contribute to the neurodegenerative process through the production of toxic molecules. Therapeutic strategies geared toward reducing inflammation and inhibiting the production of these glial-derived toxic molecules may be a promising neuroprotective strategy for the treatment of Parkinson's disease and related conditions.

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Read article at publisher's site: https://doi.org/10.1002/mds.22638

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Funding

Funders who supported this work.

MDA/Wings Over Wall Street

NIA NIH HHS (1)

Grant ID: R01 AG21617
2 publications

NIH/NINDS (2)

Grant ID: RO1 AG21617
1 publication
Grant ID: P01 NS11766-27A1
1 publication

NINDS NIH HHS (2)

Grant ID: P50 NS38370
44 publications
Grant ID: P01 NS11766-27A1
9 publications

Parkinsons Disease Foundation, USA

US Department of Defense (1)

Grant ID: DAMD 17-03-1
1 publication

Udall Parkinson's Disease Research (1)

Grant ID: P50 NS38370
1 publication

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Abstract

Full text links

References

Parkinson's disease: mechanisms and models.

Title not supplied

Nigral and extranigral pathology in Parkinson's disease.

Lewy bodies.

Title not supplied

Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr alpha-synuclein mutation.

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology.

PROGRESSIVE SUPRANUCLEAR PALSY. A HETEROGENEOUS DEGENERATION INVOLVING THE BRAIN STEM, BASAL GANGLIA AND CEREBELLUM WITH VERTICAL GAZE AND PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA.

Adams RD Salam-Adams M Striatonigral degeneration Vinken PJ Bruyn GW Klawans HL Handbook of clinical neurology. Extrapyramidal disorders 49 New York Elsevier 1986 205 212

Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure.

Citations & impact

Impact metrics

Citations of article over time

Article citations

Function and Mechanism of Abscisic Acid on Microglia-Induced Neuroinflammation in Parkinson's Disease.

Microglial response to aging and neuroinflammation in the development of neurodegenerative diseases.

Bidirectional association between Parkinson's disease and obstructive sleep apnea: a cohort study.

CRISPR/Cas9 assisted stem cell therapy in Parkinson's disease.

"Reframing" dopamine signaling at the intersection of glial networks in the aged Parkinsonian brain as innate Nrf2/Wnt driver: Therapeutical implications.

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