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Myelin and oligodendrocyte development in the canine spinal cord.

Author information

Affiliations

  • 1. Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, 53706.
      Authors
    • Mayer JA 1
    • Figari C 1
    • Radcliff AB 1
    • Mckee C 1
    • Duncan ID 1
    (5 authors)

The Journal of Comparative Neurology, 04 Sep 2015, 524(5):930-939
https://doi.org/10.1002/cne.23882 PMID: 26338416 

Abstract 

We studied the developmental pattern of oligodendrocyte differentiation and myelin formation in the fetal canine spinal cord from E40 to P0. The pattern of development matches what has been described in the spinal cord of humans, rodents, and many other species. Oligodendrocytes were first found at E40, close to the central canal, with their spread in a tangential manner to the ventral and then lateral columns. Myelin development followed the same pattern but was not seen until E46. A clear subpial zone lacking glial cells and myelin was seen in the lateral column in early development, suggesting that there may also be a radial component of migration of oligodendrocyte progenitor cells (OPCs) from a ventral site. This spatial-temporal developmental pattern seen in wild type matches a delay in myelination of the superficial tracts of the spinal cord seen in a canine myelin mutant, suggesting that the mutation prevents the distribution and differentiation of OPCs at an early, but narrow, window of time during fetal development.

Full text links 

Read article at publisher's site: https://doi.org/10.1002/cne.23882

References 

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    Funding 

    Funders who supported this work.

    Boespflug Foundation