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Progress and challenges in the engineering of non-cellulolytic microorganisms for consolidated bioprocessing.

Author information

Affiliations

  • 1. Department of Biotechnology, University of the Western Cape, Private Bag X17, Bellville 7530, South Africa.
      Authors
    • den Haan R 1
    (1 author)
  • 2. Department of Process Engineering, Stellenbosch University, Private Bag XI, Matieland 7602, South Africa.
      Authors
    • van Rensburg E 2
    • Görgens JF 2
    (2 authors)
  • 3. Department of Microbiology, Stellenbosch University, Private Bag XI, Matieland 7602, South Africa.
      Authors
    • Rose SH 3
    • van Zyl WH 3
    (2 authors)

ORCIDs linked to this article

Current Opinion in Biotechnology, 30 Oct 2014, 33:32-38
https://doi.org/10.1016/j.copbio.2014.10.003 PMID: 25445545 

Review

Abstract 

Lignocellulosic biomass is an abundant, renewable feedstock for the production of fuels and chemicals, if an efficient and affordable conversion technology can be established to overcome its recalcitrance. Consolidated bioprocessing (CBP) featuring enzyme production, substrate hydrolysis and fermentation in a single step is a biologically mediated conversion approach with outstanding potential if a fit-for-purpose microorganism(s) can be developed. Progress in developing CBP-enabling microorganisms is ongoing by engineering (i) naturally cellulolytic microorganisms for improved product-related properties or (ii) non-cellulolytic organisms exhibiting high product yields to heterologously produce different combinations of cellulase enzymes. We discuss progress on developing yeast and bacteria for the latter strategy and consider further challenges that require attention to bring this technology to market.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/j.copbio.2014.10.003

References 

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Funding 

Funders who supported this work.

Department of Science and Technology

    National Research Foundation of South Africa (1)

    South African National Energy Research Institute