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Gonadotropin-inhibitory hormone-stimulation of food intake is mediated by hypothalamic effects in chicks.

Author information

Affiliations

  • 1. Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
      Authors
    • McConn B 1
    • Wang G 1
    • Yi J 1
    • Gilbert ER 1
    • Cline MA 1
    (5 authors)
  • 2. Laboratory of Integrative Brain Sciences, Department of Biology, Waseda University, Tokyo 162-8480, Japan; Suntory Foundation for Life Sciences, Bioorganic Research Institute, Osaka, 618-8503, Japan.
      Authors
    • Osugi T 2
    (1 author)
  • 3. Laboratory of Integrative Brain Sciences, Department of Biology, Waseda University, Tokyo 162-8480, Japan.
      Authors
    • Ubuka T 3
    • Tsutsui K 3
    (2 authors)
  • 4. Division for Arts and Science, Faculty of Arts and Science, Kyushu University, Fukuoka 819-0395, Japan.
      Authors
    • Chowdhury VS 4
    (1 author)
  • 5. Department of Bioresource Sciences, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan.
      Authors
    • Furuse M 5
    (1 author)

ORCIDs linked to this article

Neuropeptides, 11 Sep 2014, 48(6):327-334
https://doi.org/10.1016/j.npep.2014.09.001 PMID: 25305807 

Abstract 

Gonadotropin-inhibitory hormone (GnIH), a 12 amino acid peptide, is expressed in the avian brain and inhibits luteinizing hormone secretion. Additionally, exogenous injection of GnIH causes increased food intake of chicks although the central mechanism mediating this response is poorly understood. Hence, the purpose of our study was to elucidate the central mechanism of the GnIH orexigenic response using 12 day post hatch layer-type chicks as models. Firstly, via mass spectrometry we deduced the chicken GnIH amino acid sequence: SIRPSAYLPLRFamide. Following this we used chicken GnIH to demonstrate that intracerebroventricular (ICV) injection of 2.6 and 7.8 nmol causes increased food intake up to 150 min following injection with no effect on water intake. The number of c-Fos immunoreactive cells was quantified in appetite-associated hypothalamic nuclei following ICV GnIH and only the lateral hypothalamic area (LHA) had an increase of c-Fos positive neurons. From whole hypothalamus samples following ICV GnIH injection abundance of several appetite-associated mRNA was quantified which demonstrated that mRNA for neuropeptide Y (NPY) was increased while mRNA for proopiomelanocortin (POMC) was decreased. This was not the case for mRNA abundance in isolated LHA where NPY and POMC were not affected but melanin-concentrating hormone (MCH) mRNA was increased. A comprehensive behavior analysis was conducted after ICV GnIH injection which demonstrated a variety of behaviors unrelated to appetite were affected. In sum, these results implicate activation of the LHA in the GnIH orexigenic response and NPY, POMC and MCH are likely also involved.

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Read article at publisher's site: https://doi.org/10.1016/j.npep.2014.09.001

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    Funding 

    Funders who supported this work.

    Kieikai Research Foundation