Europe PMC
Nothing Special   »   [go: up one dir, main page]

Europe PMC requires Javascript to function effectively.

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page.

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Murine model for study of cell-mediated immunity: protection against death from fully virulent Francisella tularensis infection.

Infection and Immunity, 01 Nov 1975, 12(5):999-1005
https://doi.org/10.1128/iai.12.5.999-1005.1975 PMID: 1193736 PMCID: PMC415388

Free full text in Europe PMC

Abstract 

To assess cell-mediated immunity in terms of host protection, an experimental model was developed in which passively transferred spleen cells from immunized AKR/J mice enabled nonimmume syngeneic recipients to survive an otherwise fatal infection with fully virulent Francisella tularensis. Donor immunization was achieved by administering live attenuted tularemia vaccine and, subsequently, the virulent streptomycin-sensitive SCHU S4 strain of F. tularensis. At selected intervals after immunization, donor spleen cells were transferred to streptomycin-treated recipients challenged subcutaneously, intravenously, or intraperitoneally with 25 to 50 minimal lethal doses of virulent streptomycin-resistant F. tularensis SCHU S5. The protection afforded by immune spleen cells was maximal (essentially 100%) 12 days after the SCHU S4 secondary immunization.

Free full text 

Logo of iaiLink to Publisher's site
Infect Immun. 1975 Nov; 12(5): 999–1005.
PMCID: PMC415388
PMID: 1193736

Murine model for study of cell-mediated immunity: protection against death from fully virulent Francisella tularensis infection.

H T Eigelsbach, D H Hunter, W A Janssen, H G Dangerfield, and S G Rabinowitz
Copyright and License information Disclaimer

Abstract

To assess cell-mediated immunity in terms of host protection, an experimental model was developed in which passively transferred spleen cells from immunized AKR/J mice enabled nonimmume syngeneic recipients to survive an otherwise fatal infection with fully virulent Francisella tularensis. Donor immunization was achieved by administering live attenuted tularemia vaccine and, subsequently, the virulent streptomycin-sensitive SCHU S4 strain of F. tularensis. At selected intervals after immunization, donor spleen cells were transferred to streptomycin-treated recipients challenged subcutaneously, intravenously, or intraperitoneally with 25 to 50 minimal lethal doses of virulent streptomycin-resistant F. tularensis SCHU S5. The protection afforded by immune spleen cells was maximal (essentially 100%) 12 days after the SCHU S4 secondary immunization.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.0M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.
 
icon of scanned page 999
999
icon of scanned page 1000
1000
icon of scanned page 1001
1001
icon of scanned page 1002
1002
icon of scanned page 1003
1003
icon of scanned page 1004
1004
icon of scanned page 1005
1005
 

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • ALLEN WP. Immunity against tularemia: passive protection of mice by transfer of immune tissues. J Exp Med. 1962 Feb 1;115:411–420. [Europe PMC free article] [Abstract] [Google Scholar]
  • Blanden RV, Lefford MJ, Mackaness GB. The host response to Calmette-Guérin bacillus infection in mice. J Exp Med. 1969 May 1;129(5):1079–1107. [Europe PMC free article] [Abstract] [Google Scholar]
  • Blanden RV, Mackaness GB, Collins FM. Mechanisms of acquired resistance in mouse typhoid. J Exp Med. 1966 Oct 1;124(4):585–600. [Europe PMC free article] [Abstract] [Google Scholar]
  • Claflin JL, Larson CL. Infection-immunity in tularemia: specificity of cellular immunity. Infect Immun. 1972 Mar;5(3):311–318. [Europe PMC free article] [Abstract] [Google Scholar]
  • Collins FM. Immunogenicity of living and heat-killed Salmonella pullorum vaccines. Infect Immun. 1973 May;7(5):735–742. [Europe PMC free article] [Abstract] [Google Scholar]
  • Collins FM. Vaccines and cell-mediated immunity. Bacteriol Rev. 1974 Dec;38(4):371–402. [Europe PMC free article] [Abstract] [Google Scholar]
  • Collins FM, Mackaness GB. The relationship of delayed hypersensitivity to acquired antituberculous immunity. I. Tuberculin sensitivity and resistance to reinfection in BCG-vaccinated mice. Cell Immunol. 1970 Sep;1(3):253–265. [Abstract] [Google Scholar]
  • EIGELSBACH HT, BRAUN W, HERRING RD. Studies on the variation of Bacterium tularense. J Bacteriol. 1951 May;61(5):557–569. [Europe PMC free article] [Abstract] [Google Scholar]
  • EIGELSBACH HT, DOWNS CM. Prophylactic effectiveness of live and killed tularemia vaccines. I. Production of vaccine and evaluation in the white mouse and guinea pig. J Immunol. 1961 Oct;87:415–425. [Abstract] [Google Scholar]
  • Eigelsbach HT, Hornick RB, Tulis JJ. Recent studies on live tularemia vaccine. Med Ann Dist Columbia. 1967 May;36(5):282–286. [Abstract] [Google Scholar]
  • Hornick RB, Eigelsbach HT. Aerogenic immunization of man with live Tularemia vaccine. Bacteriol Rev. 1966 Sep;30(3):532–538. [Europe PMC free article] [Abstract] [Google Scholar]
  • JENKIN CR, ROWLEY D. BASIS FOR IMMUNITY TO TYPHOID IN MICE AND THE QUESTION OF "CELLULAR IMMUNITY". Bacteriol Rev. 1963 Dec;27:391–404. [Europe PMC free article] [Abstract] [Google Scholar]
  • Kostiala AA, McGregor DD, Logie PS. Tularaemia in the rat. I. The cellular basis on host resistance to infection. Immunology. 1975 May;28(5):855–869. [Abstract] [Google Scholar]
  • MACKANESS GB. Cellular resistance to infection. J Exp Med. 1962 Sep 1;116:381–406. [Europe PMC free article] [Abstract] [Google Scholar]
  • MACKANESS GB. THE IMMUNOLOGICAL BASIS OF ACQUIRED CELLULAR RESISTANCE. J Exp Med. 1964 Jul 1;120:105–120. [Europe PMC free article] [Abstract] [Google Scholar]
  • Mackaness GB. The influence of immunologically committed lymphoid cells on macrophage activity in vivo. J Exp Med. 1969 May 1;129(5):973–992. [Europe PMC free article] [Abstract] [Google Scholar]
  • Mackaness GB. Resistance to intracellular infection. J Infect Dis. 1971 Apr;123(4):439–445. [Abstract] [Google Scholar]
  • Mackaness GB, Hill WC. The effect of anti-lymphocyte globulin on cell-mediated reistance to infection. J Exp Med. 1969 May 1;129(5):993–1012. [Europe PMC free article] [Abstract] [Google Scholar]
  • McGregor DD, Koster FT, Mackaness GB. The short lived small lymphocyte as a mediator of cellular immunity. Nature. 1970 Nov 28;228(5274):855–856. [Abstract] [Google Scholar]
  • OVERHOLT EL, TIGERTT WD, KADULL PJ, WARD MK, CHARKES ND, RENE RM, SALZMAN TE, STEPHENS M. An analysis of forty-two cases of laboratory-acquired tularemia. Treatment with broad spectrum antibiotics. Am J Med. 1961 May;30:785–806. [Abstract] [Google Scholar]
  • Robson HG, Vas SI. Resistance of inbred mice to Salmonella typhimurium. J Infect Dis. 1972 Oct;126(4):378–386. [Abstract] [Google Scholar]
  • SASLAW S, EIGELSBACH HT, PRIOR JA, WILSON HE, CARHART S. Tularemia vaccine study. II. Respiratory challenge. Arch Intern Med. 1961 May;107:702–714. [Abstract] [Google Scholar]
  • SASLAW S, EIGELSBACH HT, WILSON HE, PRIOR JA, CARHART S. Tularemia vaccine study. I. Intracutaneous challenge. Arch Intern Med. 1961 May;107:689–701. [Abstract] [Google Scholar]
  • Sawyer WD, Dangerfield HG, Hogge AL, Crozier D. Antibiotic prophylaxis and therapy of airborne tularemia. Bacteriol Rev. 1966 Sep;30(3):542–550. [Europe PMC free article] [Abstract] [Google Scholar]
  • SEVER JL. Passive transfer of resistance to tuberculosis through use of monocytes. Proc Soc Exp Biol Med. 1960 Feb;103:326–329. [Abstract] [Google Scholar]
  • SUTER E, RAMSEIAR H. CELLULAR REACTIONS IN INFECTION. Adv Immunol. 1964;27:117–173. [Abstract] [Google Scholar]
  • THORPE BD, MARCUS S. PHAGOCYTOSIS AND INTRACELLULAR FATE OF PASTEURELLA TULARENSIS. 3. IN VIVO STUDIES WITH PASSIVELY TRANSFERRED CELLS AND SERA. J Immunol. 1965 Apr;94:578–585. [Abstract] [Google Scholar]
  • Zinkernagel RM, Blanden RV, Langman RE. Early appearance of sensitized lymphocytes in mice infected with Listeria monocytogenes. J Immunol. 1974 Feb;112(2):496–501. [Abstract] [Google Scholar]
Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

Full text links 

Read article at publisher's site: https://doi.org/10.1128/iai.12.5.999-1005.1975

Read article for free, from open access legal sources, via Unpaywall: https://iai.asm.org/content/iai/12/5/999.full.pdfUnpaywall

Free after 4 months at iai.asm.org
http://iai.asm.org/cgi/reprint/12/5/999

Free to read at iai.asm.org
http://iai.asm.org/cgi/content/abstract/12/5/999

Citations & impact 

Impact metrics

20
Citations
Jump to Citations

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/80604681
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/80604681

Smart citations by scite.ai
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1128/iai.12.5.999-1005.1975

Supporting
Mentioning
Contrasting
0
12
0

Article citations

Go to all (20) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.