Breaking the mitochondrial barrier.

Abstract

Pro- and anti-apoptotic members of the Bcl-2 family control the permeability of the outer mitochondrial membrane. They could do this either by forming autonomous pores in the membrane or by collaborating with components of the permeability transition pore. Here we discuss why we favour the first of these possibilities.

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References

Articles referenced by this article (46)

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Jane EP, Reslink MC, Gatesman TA, Halbert ME, Miller TA, Golbourn BJ, Casillo SM, Mullett SJ, Wendell SG, Obodo U, Mohanakrishnan D, Dange R, Michealraj A, Brenner C, Agnihotri S, Premkumar DR, Pollack IF
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References

Mitochondria as the central control point of apoptosis.

Energy supply and the shape of death in neurons and lymphoid cells.

Interdigital cell death can occur through a necrotic and caspase-independent pathway.

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition.

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.

Molecular characterization of mitochondrial apoptosis-inducing factor.

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis.

Structure of Bax: coregulation of dimer formation and intracellular localization.

Wei, M. C. et al. tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev. 14, 2061–2071 (2000).

TNF-alpha signals apoptosis through a bid-dependent conformational change in Bax that is inhibited by E1B 19K.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

Critical roles of tubular mitochondrial ATP synthase dysfunction in maleic acid-induced acute kidney injury.

A novel protein extracted from Hemerocallis citrina Borani inhibits hepatocellular carcinoma cell proliferation by regulating mitochondria-dependent apoptosis and aerobic glycolysis.

The Potential Biotherapeutic Targets of Contrast-Induced Acute Kidney Injury.

Mitochondria Have Made a Long Evolutionary Path from Ancient Bacteria Immigrants within Eukaryotic Cells to Essential Cellular Hosts and Key Players in Human Health and Disease.

Targeting mitochondrial energetics reverses panobinostat- and marizomib-induced resistance in pediatric and adult high-grade gliomas.

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Breaking the mitochondrial barrier.

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References

Wei, M. C. et al. tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev. 14, 2061–2071 (2000).

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