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Functional delineation of three groups of the ATP-dependent family of chromatin remodeling enzymes.

Author information

Affiliations

  • 1. Program in Molecular Medicine and Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
      Authors
    • Boyer LA 1
    (1 author)

ORCIDs linked to this article

The Journal of Biological Chemistry, 01 Jun 2000, 275(25):18864-18870
https://doi.org/10.1074/jbc.m002810200 PMID: 10779516 

Abstract 

ATP-dependent chromatin remodeling enzymes antagonize the inhibitory effects of chromatin. We compare six different remodeling complexes: ySWI/SNF, yRSC, hSWI/SNF, xMi-2, dCHRAC, and dNURF. We find that each complex uses similar amounts of ATP to remodel nucleosomal arrays at nearly identical rates. We also perform assays with arrays reconstituted with hyperacetylated or trypsinized histones and isolated histone (H3/H4)(2) tetramers. The results define three groups of the ATP-dependent family of remodeling enzymes. In addition we investigate the ability of an acidic activator to recruit remodeling complexes to nucleosomal arrays. We propose that ATP-dependent chromatin remodeling enzymes share a common reaction mechanism and that a key distinction between complexes is in their mode of regulation or recruitment.

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Read article at publisher's site: https://doi.org/10.1074/jbc.m002810200

Read article for free, from open access legal sources, via Unpaywall: https://repository.ubn.ru.nl/bitstream/handle/2066/129327/1/129327.pdfUnpaywall

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Funding 

Funders who supported this work.

NIGMS NIH HHS (5)