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Pancreas and beta-cell development: from the actual to the possible.

Author information

Affiliations

  • 1. University of Utah, Department of Human Genetics, Salt Lake City, UT 84112, USA.
      Authors
    • Murtaugh LC 1
    (1 author)

Development (Cambridge, England), 21 Dec 2006, 134(3):427-438
https://doi.org/10.1242/dev.02770 PMID: 17185316 

Review

Abstract 

The development of insulin-producing pancreatic beta (beta)-cells represents the culmination of a complex developmental program. Cells of the posterior foregut assume a pancreatic identity, cells within the expanding pancreatic primordia adopt an endocrine fate, and a subset of these precursors becomes competent to generate beta-cells. Postnatally, beta-cells are primarily maintained by self-duplication rather than new differentiation. Although major gaps in our knowledge still persist, experiments across several organisms have shed increasing light on the steps of beta-cell specification and differentiation. Increasing our understanding of the extrinsic, as well as intrinsic, mechanisms that control these processes should facilitate efforts to regenerate this important cell type in humans.

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Read article at publisher's site: https://doi.org/10.1242/dev.02770

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