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Mitotic chromosome structure and condensation.

Author information

Affiliations

  • 1. Department of Cell and Developmental Biology, University of Illinois, Urbana-Champaign B107 CLSL 601 S. Goodwin Ave. Urbana, IL 61802, USA.
      Authors
    • Belmont AS 1
    (1 author)

Current Opinion in Cell Biology, 12 Oct 2006, 18(6):632-638
https://doi.org/10.1016/j.ceb.2006.09.007 PMID: 17046228 

Review

Abstract 

Mitotic chromosome structure has been the cell biology equivalent of a 'riddle, wrapped in a mystery, inside an enigma'. Observations that genetic knockout or knockdown of condensin subunits or topoisomerase II cause only minimal perturbation in overall chromosome condensation, together with analysis of early stages of chromosome condensation and effects produced by histone H1 depletion, suggest a need to reconsider textbook models of mitotic chromosome condensation and organization.

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Read article at publisher's site: https://doi.org/10.1016/j.ceb.2006.09.007

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Funding 

Funders who supported this work.

NIGMS NIH HHS (2)