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Stage-specific changes in gene expression in acutely isolated mouse CNS progenitor cells.

Author information

Affiliations

  • 1. Center for Neuropharmacology and Neuroscience, Albany Medical College, NY 12208, USA.
      Authors
    • Abramova N 1
    (1 author)

Developmental Biology, 01 Jul 2005, 283(2):269-281
https://doi.org/10.1016/j.ydbio.2005.03.040 PMID: 15890332 

Abstract 

Neural progenitor cells can be derived from a variety of developmental stages when they are preferentially proliferating, undergoing neurogenesis or undergoing gliogenesis. We used FACS sorting and the LeX surface marker to enrich neural progenitor cells from different embryonic stages and adult and compared their gene expression profiles using Affymetrix Microarrays. Our results show that, while there are common genes expressed in the progenitor cell population from all stages, there are also significant differences in gene expression patterns that correlate with stage-related behaviors. These data indicate that progenitor cells change during development and that adult and embryonic neural progenitor cells are intrinsically different.

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Read article at publisher's site: https://doi.org/10.1016/j.ydbio.2005.03.040

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Funding 

Funders who supported this work.

NINDS NIH HHS (2)