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Aneuploidy and cancer.

Author information

Affiliations

  • 1. The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, Maryland 21231, USA.
      Authors
    • Rajagopalan H 1
    (1 author)

Nature, 01 Nov 2004, 432(7015):338-341
https://doi.org/10.1038/nature03099 PMID: 15549096 

Review

Abstract 

In contrast to normal cells, aneuploidy--alterations in the number of chromosomes--is consistently observed in virtually all cancers. A growing body of evidence suggests that aneuploidy is often caused by a particular type of genetic instability, called chromosomal instability, which may reflect defects in mitotic segregation in cancer cells. A better understanding of the molecular mechanisms leading to aneuploidy holds promise for the development of cancer drugs that target this process.

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Read article at publisher's site: https://doi.org/10.1038/nature03099

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